Journal of Pain Research最新文献

{"title":"The Optimal Patient Profile and Appropriate Role of Spinal Cord Stimulation (SCS) for Patients with Persistent Spinal Pain Syndrome-Type 1 (PSPS-T1) Not Suitable for Spine Surgery: A European Modified Delphi Consensus.","authors":"Tobias L Schulte, María Reyes Fernández-Marín, Roberto Gazzeri, Oliver Hamel, Jan Willem Kallewaard, Kavita Poply, Iris Smet, Jan Vesper, Erik Van de Kelft","doi":"10.2147/JPR.S533951","DOIUrl":"10.2147/JPR.S533951","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic lower back pain (CLBP) is a debilitating condition, and a leading cause of disability associated with significant negative impacts on patients' quality of life (QoL) and mental health. In both Persistent Spinal Pain Syndrome Types 1 and 2 (PSPS-T1/2) patients, spinal cord stimulation (SCS) therapy has shown favorable outcomes including improved QoL and patient satisfaction, reductions in opioid use, and an acceptable safety profile. This consensus aimed to define the PSPS-T1 patient profile for SCS to maximize its benefits in clinical settings and allow budget holders to quantify the patient population and allocate budget accordingly.</p><p><strong>Methods: </strong>This study used a modified Delphi methodology. A literature review was conducted, followed by multidisciplinary steering group discussions that resulted in the development of 32 statements under five key domains. These statements, along with a four-point Likert scale, were incorporated into a survey distributed across seven European countries to 144 healthcare professionals experienced in pain management. The respondents included orthopedic surgeons (n=50), pain specialists (n=48), and neurosurgeons (n=46). The consensus agreement threshold was set at 75%.</p><p><strong>Results: </strong>Consensus was achieved for 30 of the 32 statements, with 11 statements (34%) reaching ≥90% agreement. Two statements did not achieve consensus. Based on the consensus achieved in the study, an algorithm is proposed to assist in patient selection for SCS.</p><p><strong>Conclusion: </strong>This consensus provides recommendations on optimal patient profiles, referral processes, diagnostic procedures, and a decision-making algorithm for PSPS-T1 patients who are ineligible for spine surgery in Europe.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4959-4973"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study.","authors":"Jie-Hai Chen, Nian-Hua Deng, Yong-Cheng Li, Xiao-Chun Zhu, Ping Ge, Xiang-Dong Wang, Peng Jiang, Zhi-Wei Wen, Gui-Ting Huang, Qing-Ming Luo, Yuan-Yan Tu","doi":"10.2147/JPR.S536665","DOIUrl":"10.2147/JPR.S536665","url":null,"abstract":"<p><strong>Background: </strong>Cumulative evidence from observational studies has revealed associations between chronic pain (CP) and asthma. However, it remains unclear whether these associations indicate a causal relationship. In this study, we aimed to assess the causal relationships between CP and asthma.</p><p><strong>Methods: </strong>First, linkage disequilibrium score regression (LDSC) analysis was used to estimate the genetic correlations between 9 types of CP (including multisite chronic pain, knee, back, neck/shoulder, headaches, hip, stomach/abdominal, facial, and general CP) and asthma. Conventional Mendelian randomization (MR) approaches and a new MR method, Causal Analysis Using Summary Effect estimates (CAUSE), were performed to test bidirectional causal relationships between genetically predicted CP and asthma. Finally, mediation analysis was conducted to establish whether immune cells and inflammatory cytokines causally mediate any associations.</p><p><strong>Results: </strong>For the LDSC analysis, several significant genetic correlations (rg) were observed, such as multisite chronic pain (MCP) and asthma (rg = 0.442, P = 7.23×10^-52). For the MR analysis, we identified that genetically determined MCP (odds ratio [OR] 2.34, 95% confidence interval [CI] 1.84-2.97, P = 3.51×10^-12) was significantly associated with a higher risk of asthma. For the mediation analysis, the three immune-cell phenotypes (including CD3 on activated CD4 regulatory T cells, CD3 on activated and secreting CD4 regulatory T cells, and CD3 on CD39+ CD4+ T cells) were each found to mediate 4.6-5.0% of the total effect linking MCP to asthma, underscoring their partial mediating role in this causal pathway. Unexpectedly, other types of pain showed no correlation with asthma risk.</p><p><strong>Conclusion: </strong>Our findings revealed that MCP is significantly associated with a higher risk of asthma, which is partially mediated by immune cells.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"5023-5035"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in Knee Osteoarthritis: A Narrative Review of Clinical Efficacy and Neuroimmune-Endocrine Mechanisms.","authors":"Junru Jiao, Baoqiang Dong, Yiyan Han, Qu Zheng, Xingxing Lin","doi":"10.2147/JPR.S546687","DOIUrl":"10.2147/JPR.S546687","url":null,"abstract":"<p><strong>Purpose: </strong>Knee osteoarthritis (KOA) is a leading cause of global pain and disability and warrants complementary therapy. This review provides evidence of the clinical efficacy of acupuncture and the multisystem regulatory mechanisms of KOA.</p><p><strong>Methods: </strong>We analyzed clinical trials and mechanistic studies of acupuncture in the treatment of KOA.</p><p><strong>Results: </strong>Acupuncture-particularly electroacupuncture (EA) significantly reduced pain (VAS/WOMAC) compared with sham acupuncture and conventional care (<i>P</i> < 0.05). Clinical trials demonstrate that combining acupuncture with exercise significantly enhances functional outcomes. Mechanistically, acupuncture modulates neuroendocrine pathways through three key actions: (1) suppressing pro-inflammatory cytokines (eg, TNF-α, IL-1β); (2) activating the Melatonin/cAMP/PKA/CREB signaling cascade; (3) altering functional connectivity in central pain-processing regions. Controversies persist regarding the mechanisms, optimal techniques, and outcome standardization.</p><p><strong>Conclusion: </strong>Acupuncture is an effective complementary therapy for KOA. Future research should prioritize long-term efficacy, personalized protocols, technology integration, and multidisciplinary strategies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4989-4998"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Neuroimaging of Breast Cancer Pain: An Overview.","authors":"Pu Wei, Yuqing Liu, Jinming Tong, Qingwei Zhang, Zhiqiang Qiu, Xiaoxue Xu","doi":"10.2147/JPR.S540502","DOIUrl":"10.2147/JPR.S540502","url":null,"abstract":"<p><p>Breast cancer is currently the most common malignant tumor, primarily affecting women, and it frequently leads to chronic pain that significantly impairs physical and mental health. Neuroimaging studies have demonstrated that breast cancer-related pain is associated with specific brain alterations, including changes in activation, connectivity, and structure of pain-processing regions. This review synthesizes findings on functional and structural brain changes related to chronic pain in breast cancer and compares them with non-cancer chronic pain patterns. By integrating recent evidence, it proposes a conceptual framework to advance the understanding of pain mechanisms and supports personalized pain management strategies to improve quality of life.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4975-4988"},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reductions in Perceived Injustice are Associated with Reductions in Pain Catastrophizing in Individuals with Low Back Pain.","authors":"Naz Y Alpdogan, Marie-France Coutu, Marie-José Durand, Junie S Carrière","doi":"10.2147/JPR.S518634","DOIUrl":"10.2147/JPR.S518634","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined whether reductions in pain catastrophizing were associated with reductions in perceived injustice in individuals with occupational low back pain receiving physical therapy combined with a brief psychological intervention (Empowered Relief) to improve pain self-management skills.</p><p><strong>Methods: </strong>A secondary analysis of a quasi-experimental study was conducted with 63 participants with subacute and chronic low back pain. Perceived injustice and pain catastrophizing were measured at baseline (T1) and four weeks post-intervention (T2). Correlation and regression analyses were performed to identify predictors of changes in perceived injustice. Ethical approval was obtained from the Université de Sherbrooke Research Ethics Board (#2022-3392).</p><p><strong>Results: </strong>Changes in pain catastrophizing were strongly associated with changes in perceived injustice (r = 0.723, <i>p</i> < 0.001). Regression analyses revealed that pain stage and reductions in pain catastrophizing were significantly associated with decreases in perceived injustice. Regression analyses also revealed that reductions in the \"rumination\" subscale of pain catastrophizing significantly predicted changes in both subscales of perceived injustice.</p><p><strong>Conclusion: </strong>The results demonstrate that reductions in pain catastrophizing are associated with reductions in perceived injustice during the subacute phase. The findings also shed light on shared mechanisms between pain catastrophizing and perceived injustice, emphasizing the role of rumination. The findings from this study underscore the importance of early psychological intervention for occupational low back pain, particularly in the subacute phase to improve recovery.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4947-4957"},"PeriodicalIF":2.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Acupotomy Modulation of NLRP3/Caspase-1/GSDMD Pathway on Chondrocyte Pyroptosis in Knee Osteoarthritis.","authors":"Yingjie Wang, Yuan Chen, Yao Yang, Yanling Zhou, Yonghui Yang, Junchen Zhu","doi":"10.2147/JPR.S537826","DOIUrl":"10.2147/JPR.S537826","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by progressive cartilage degradation and inflammation, often leading to pain and reduced mobility. Current therapeutic approaches, including pharmacological and surgical interventions, provide symptomatic relief but rarely address the underlying pathological mechanisms effectively. Acupotomy therapy, a minimally invasive technique integrating traditional Chinese medicine and modern surgical concepts, has shown promise in alleviating KOA symptoms. However, its mechanisms, particularly concerning chondrocyte pyroptosis, remain underexplored. This study investigates the role of acupotomy therapy in modulating chondrocyte pyroptosis via the NLRP3/Caspase-1/GSDMD signaling pathway in a rabbit KOA model.</p><p><strong>Methods: </strong>Forty New Zealand rabbits were randomized into four groups: control, model, acupotomy, and drug-treated groups. A KOA model was induced via intra-articular injection of papain. Interventions included acupotomy therapy and oral celecoxib. Outcomes were assessed using behavioral scoring, micro-CT imaging, histological staining, serum inflammatory markers (ELISA), and the expression of NLRP3 inflammasome-associated proteins (qPCR and Western blot).</p><p><strong>Results: </strong>Acupotomy therapy significantly improved behavioral scores and reduced knee joint space narrowing. Histological analyses revealed improved cartilage integrity and decreased inflammatory markers. Expression levels of NLRP3, Caspase-1, ASC, and GSDMD were downregulated in the acupotomy group compared to the model group.</p><p><strong>Conclusion: </strong>This study highlights the therapeutic potential of acupotomy therapy in alleviating KOA symptoms and reducing chondrocyte pyroptosis by modulating the NLRP3 inflammasome pathway. These findings provide a mechanistic basis for its application in KOA treatment and a foundation for further clinical exploration.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4935-4945"},"PeriodicalIF":2.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of Factors Associated with Chronic Musculoskeletal Pain, Pain Management Preferences, Coping Strategies, and Health-Related Quality of Life Among Older People: A Cross-Cultural Study.","authors":"Ugur Cavlak, Ivan Jurak, Ligia Rusu, Guzin Kaya Aytutuldu, Mirjana Telebuh, Oana Bianca Budeanca-Babolea, Eylül Pınar Kısa, Zelimir Bertic, Eva Nicoleta Ilie, Gordana Grozdek Covcic, Denisa Piele, Margareta Begić, Mihai Marian Dragomir","doi":"10.2147/JPR.S525968","DOIUrl":"10.2147/JPR.S525968","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic musculoskeletal pain is common among older adults (OAs). This study aimed to identify and describe the characteristics of chronic musculoskeletal pain, pain management, and coping strategies among OAs from Turkey, Croatia, and Romania. The study also aimed to explore cultural differences in pain experience and management.</p><p><strong>Methods: </strong>A total of 337 OAs with chronic pain participated: 100 from Turkey, 131 from Croatia and 106 from Romania. The mean age was 76.3 years in Croatia, 73.1 years in Romania, and 74.0 years in Turkey. The majority of participants in Croatia and Romania were female, while the majority of participants in Turkey were male. A structured questionnaire was used to explore four main topics, including factors influencing pain, coping strategies, management strategies, and health-related quality of life.</p><p><strong>Results: </strong>Significant differences in pain-related factors, pain management, and coping strategies were found between the three countries (p≤0.05). Physical activity, relaxation exercises, and warm showers/hot packs were associated with pain reduction. Climbing stairs was a significant pain increasing factor in both Romania and Turkey, with participants in these countries more than 2.5 times more likely to report it as a pain increasing factor compared to Croatia. Sitting had the opposite effect in Romania and Turkey. Significant predictors included higher visual analog scale-VAS scores, which were associated with worse self-rated health. Country of origin also influenced health perceptions, with Romanians less likely to report better health than Croatians.</p><p><strong>Discussion: </strong>The findings highlight the cultural implications of pain perception and management. They reveal that older adults' coping strategies and health-related quality of life are shaped not only by physical factors but also by beliefs and health perceptions unique to each country and influenced by culture. Education, including physical activity, medication use, and non-pharmacological methods like physiotherapy and interventions that consider cultural context can enhance pain control and health among older adults.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4915-4934"},"PeriodicalIF":2.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Preoperative Psychological Symptoms and Chronic Postsurgical Pain in Older Patients Undergoing off-Pump Coronary Artery Bypass Grafting: Mediation Analysis of Acute Pain.","authors":"Sichen Cui, Shizhao Wang, Lichao Di, Luguang Yan, Peiying Huang, Xueji Wang, Zheng Fu, Lining Huang","doi":"10.2147/JPR.S537096","DOIUrl":"10.2147/JPR.S537096","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between preoperative psychological symptoms and chronic postsurgical pain (CPSP) in older patients undergoing off-pump coronary artery bypass grafting, and explore the mediating effect of acute postsurgical pain.</p><p><strong>Patients and methods: </strong>A total of 172 patients aged ≥60 years, undergoing off-pump CABG were enrolled. Preoperative anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Acute pain intensity was recorded daily (postoperative days 1-5), with time-weighted average (TWA) scores calculated. CPSP was defined as persistent pain at 3 months after surgery. Logistic regression evaluated associations between preoperative psychological symptoms (individually and by stratification) and CPSP. Mediation analysis explored the role of acute pain between preoperative psychological factors and CPSP.</p><p><strong>Results: </strong>Prevalence of CPSP was 37.8% (29.1% mild, 8.7% moderate-to-severe). CPSP patients exhibited higher female proportion (36.9%, <i>P</i>=0.012), precordial pain (56.9%, <i>P</i>=0.044), anxiety (46.2%, <i>P</i><0.001), depression (35.4%, <i>P</i><0.001), and TWA scores (4.0 vs 3.0, <i>P</i><0.001). Preoperative anxiety (OR = 3.64, <i>P</i> = 0.002) and depression (OR = 3.26, <i>P</i> = 0.004) independently predicted CPSP, with comorbid symptoms conferring higher risk (OR = 7.83, <i>P</i> = 0.002). Acute pain partially mediated anxiety-CPSP association (indirect effect: 7.7%; <i>P</i> = 0.002).</p><p><strong>Conclusion: </strong>Preoperative anxiety and depression elevate CPSP risk in older off-pump CABG patients. Acute postsurgical pain partially mediates the anxiety-CPSP relationship. Integrated perioperative strategies targeting psychological health and pain management are critical to mitigate long-term pain outcomes.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4901-4913"},"PeriodicalIF":2.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Short- and Long-Term Efficacy of Non-Invasive Brain Stimulation for Migraine: A Meta-Analysis.","authors":"Mengya Liu, Yongxia Yong, Hui Zou, Luping Yang, Jinghua Qian","doi":"10.2147/JPR.S529622","DOIUrl":"10.2147/JPR.S529622","url":null,"abstract":"<p><strong>Purpose: </strong>Non-invasive brain stimulation (NIBS) has shown promising potential in the treatment of migraine; however, its short- and long-term efficacy remains uncertain. This meta-analysis evaluated the effects of NIBS on multiple migraine-related clinical outcomes in both short- and long-term follow-ups.</p><p><strong>Methods: </strong>This PRISMA-compliant review (PROSPERO: CRD42024529488) included RCTs on NIBS for migraine. A comprehensive search was conducted in PubMed, Scopus, The Cochrane, EMBASE, Web of Science, CNKI, and VIP up to April 11, 2024. Outcomes consisted of headache frequency, pain intensity, duration, analgesic intake, and adverse effects. Analyses used RevMan 5.3 and STATA 17.0.</p><p><strong>Results: </strong>Thirteen studies (596 participants) were included. In terms of short-term outcomes, NIBS significantly reduced headache frequency (SMD = -1.47, 95% CI: -2.13 to -0.82) and pain intensity (SMD = -2.09, 95% CI: -3.36 to -0.83). During long-term follow-up, significant effects were still observed at <3 months (headache frequency: SMD = -1.13, 95% CI: -1.90 to -0.35; pain intensity: -0.66 95% CI: -1.02 to -0.30) and at 6-12 months (headache frequency: SMD = -3.95, 95% CI: -7.44 to -0.45; pain intensity: SMD = -2.55 95% CI: -4.73 to -0.36, with no significant improvements at 3-6 months. NIBS also provided short-term benefits in pain duration and analgesic use. Adverse event rates did not differ between groups. Meta-regression linked target and device to short-term efficacy.</p><p><strong>Conclusion: </strong>NIBS is an effective, preventive, and safe treatment for migraine but its long-term efficacy is not evident.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4883-4900"},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Reaffirmation to Our Call for Reform: Response to Rebuttal Letter Regarding \"A Call for Reckoning and Reform in Interventional Pain Medicine and Neuromodulation Research\" [Response to Letter].","authors":"Ryan S D'Souza, Michael E Schatman, Nasir Hussain","doi":"10.2147/JPR.S566855","DOIUrl":"10.2147/JPR.S566855","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4871-4873"},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}