Journal of Pain Research最新文献

{"title":"Efficacy and Central Mechanism of Acupuncture Treatment for Subacute Nonspecific Low Back Pain: A Clinical Neuroimaging Protocol.","authors":"Jia Ren, Zhen Gao, Bo-Ya Chang, Meng-Jie Cui, Hai-Jun Wang","doi":"10.2147/JPR.S529456","DOIUrl":"10.2147/JPR.S529456","url":null,"abstract":"<p><strong>Purpose: </strong>The chronification of pain is a multifaceted process, and low back pain (LBP), being one of the most prevalent health concerns globally, is particularly prone to developing into a chronic condition. Acupuncture is a common method of treating LBP in Chinese medicine, which is safe and effective. However, its mechanism of action is unclear, and more data are needed to support its application in LBP.</p><p><strong>Patients and methods: </strong>This study is a randomized controlled neuroimaging trial, involving 120 subacute LBP patients assigned to the true acupuncture group, the sham acupuncture group, or the waiting list control group. The whole study period includes a 4-week treatment period and an 8-week follow-up period. The visual analog scale, Oswestry Disability Index, range of motion, and pressure pain threshold will be used to evaluate clinical efficacy, the short-form 36-item health survey and Pittsburgh Sleep Quality Index will be used to evaluate quality of life, the self-rating anxiety scale and self-rating depression scale will be used for assessing emotional state. The magnetic resonance imaging (MRI) scans will be performed to detect cerebral activity changes between the three groups of patients before and after treatment, as well as during follow-up periods. The clinical data and MRI data will be analyzed, respectively. Correlation analysis will be used to explore the correlation between neuroimaging data and clinical indicators.</p><p><strong>Conclusion: </strong>This study will provide rigorous evidence for the use of acupuncture to prevent the chronic progression of low back pain.</p><p><strong>Trial registration: </strong>International Traditional Medicine Clinical Trial Registry ITMCTR2024000581, Registered on 17 October 2024.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3299-3308"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Acupuncture in the Treatment of Uterine Contraction Pain Post-Cesarean Section: Protocol of a Randomized Controlled Trial.","authors":"Yuanzheng Deng, Zhengping Li, Tiankui Zhang, Xin Tang, Yan Luo, Qifu Li, Shumin Zhang, Zili Liu, Diwei Tang, Zhenghai Ai, Taipin Guo, Fanrong Liang","doi":"10.2147/JPR.S531188","DOIUrl":"10.2147/JPR.S531188","url":null,"abstract":"<p><strong>Purpose: </strong>Uterine contraction pain post-cesarean section (UCPCS) is one of the main complaints for mothers in the early stages of the puerperium. Acupuncture, a non-pharmacological therapy, has shown sound analgesic effects with almost no toxic side effects. This study uses acupuncture as an intervention and aimed to provide strong evidence for the clinical efficacy of acupuncture in treating UCPCS.</p><p><strong>Patients and methods: </strong>This single-blind, randomized controlled trial (RCT) was conducted at the Ludian County Hospital of Traditional Chinese Medicine, China. Participants (138) are randomly assigned in a 1:1 ratio to either an observation or control group following cesarean section. Both groups receive routine postpartum care, the control group with sham acupuncture and the observation group with conventional acupuncture for 3 days. The primary outcome is the mean Visual Analogue Scale (VAS) score of the UCPCS. Secondary outcomes include the mean of UCPCS intensity, frequency, total duration, number of days to disappear, amount of vaginal bleeding and lactation, time to first lactation, and the Edinburgh Postnatal Depression Scale (EPDS) score. The final results will be analyzed in accordance with the intention-to-treat (ITT) principle using SPSS V.28.0.</p><p><strong>Discussion: </strong>This is the first RCT using non-penetrating sham acupuncture as a control to validate the clinical efficacy of acupuncture for UCPCS. The results of this study are expected to provide an effective therapeutic option for UCPCS, as well as offer clinicians and researchers strong evidence regarding non-pharmacological interventions.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3263-3274"},"PeriodicalIF":2.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Applications and Prescriptions of Motion Style Acupuncture Treatment for Musculoskeletal Pain: A Scoping Review of Clinical Controlled Trials.","authors":"Yetong Chen, Fenglin Zhu, Yang Zhu, Yucheng Duan, Zhenmin Bai","doi":"10.2147/JPR.S529676","DOIUrl":"10.2147/JPR.S529676","url":null,"abstract":"<p><strong>Purpose: </strong>Motion style acupuncture treatment (MSAT) is a new treatment which comprises acupuncture therapy and exercise therapy. Musculoskeletal pain is highly prevalent and a significant contributor to global disability and disease. In recent years, an increasing number of studies have applied MSAT to the management of musculoskeletal pain. This scoping review systematically collected clinical studies on the use of MSAT in the management of different musculoskeletal pain conditions and identified any adverse events.</p><p><strong>Methods: </strong>Seven databases were searched from their inception through to 2024. RCTs and CCTs on MSAT for pain conditions meeting the inclusion criteria were identified. Data were extracted on patients, interventions, details of MSAT, control treatments and outcomes.</p><p><strong>Results: </strong>This review included 36 clinical studies. These included, 27 (75%) RCTs and 9 (25%) CCTs, treating 2620 patients with 16 different pain-related diseases or symptoms. The most frequently reported conditions were acute lumbar sprain (8, 22.22%), adhesive capsulitis (5, 13.89%). Selection of movement and acupuncture was different in the treatment of different musculoskeletal pain conditions. MSAT was used alone in about one-third of the studies and of the remaining studies it was combined with other treatment. All studies reported relevant outcomes of pain and 9 (25%) adverse events.</p><p><strong>Conclusion: </strong>MSAT, which seems to be a promising intervention used in the management of diverse musculoskeletal pain conditions, has been gradually studied in China and Korea. However, given the variety of study designs and reported treatment outcomes, conclusions about the evidence for MSAT for specific conditions are not possible at this stage.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3275-3287"},"PeriodicalIF":2.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture Prevent and Treat Perioperative Cognitive Impairment in Elderly Patients Undergoing Hip Surgery: A Protocol for a Randomized Controlled Trial.","authors":"Qinqin Fang, Jing Xie, Shiyu Zheng, Yuchao Hou, Mengdie Wu, Yijing Chen, Yuechang Yang, Gengqi Wang, Jing Li","doi":"10.2147/JPR.S511236","DOIUrl":"10.2147/JPR.S511236","url":null,"abstract":"<p><strong>Background: </strong>Electroacupuncture is effective in treating perioperative neurocognitive disorder (PND) and has good application prospects in the prevention and treatment of PND. However, the mechanism of electroacupuncture treatment for PND is comparatively unexplored.</p><p><strong>Methods/design: </strong>This is a single-center clinical, prospective randomized controlled clinical trial protocol. 180 patients will be randomly divided into the treatment group and the control group in a ratio of 1:1. Both groups of subjects received routine care, while the treatment group will receive electroacupuncture treatment twice a day for 10 days. Acupoints will include Baihui (DU20), Shangxing (DU23), Yintang (EX-HN3), Meichong (BL3), Fengchi (GB20), Cuanzhu (BL2), Laogong (PC8), Hegu (LI4), and Zusanli (ST36). The primary outcome measure is the Mini-mental State Examination (MMSE). And the secondary outcome measures are the Confusion Assessment Method (CAM), Visual Analog Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), neuron-specific enolase (NSE), superoxide dismutase (SOD), central nervous system-specific protein (s100-β) in serum. The outcome measures will be evaluated at baseline, during treatment and 1 week after treatment. What's more, the incidence of non-delirium complications and mortality within 30 days will also be measured.</p><p><strong>Discussion: </strong>Results of this trial are expected to clarify the value of electroacupuncture performed on perioperative cognitive impairment in elderly patients undergoing hip surgery.</p><p><strong>Ethics: </strong>This trial has been approved by the Ethics Committee of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine (No.2024-037).</p><p><strong>Trial registration: </strong>International Traditional Medicine Clinical Trial Registry, ITMCTR2024000298 (http://itmctr.ccebtcm.org.cn/), registered on 25 August, 2024. The trial will comply with the Declaration of Helsinki.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3289-3297"},"PeriodicalIF":2.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically Reducing/Eliminating Chronic Neuropathic Pain by Bridging Peripheral Nerve Gaps with an Autograft within a PRP-Filled Collagen Tube.","authors":"Damien P Kuffler, Onix Reyes, Ivan J Sosa, William F Micheo, Jose M Santiago-Figueroa, Christian A Foy","doi":"10.2147/JPR.S523451","DOIUrl":"10.2147/JPR.S523451","url":null,"abstract":"<p><strong>Purpose: </strong>Peripheral nerve trauma is associated with 50-79% of individuals developing chronic neuropathic pain. No technique reliably induces long-term chronic neuropathic pain reduction/elimination.</p><p><strong>Patients and methods: </strong>This study compared the influence of bridging peripheral nerve gaps with an autograft vs an autograft within a platelet-rich plasma- (PRP) filled collagen tube (PRP repair) on the level of long-term chronic neuropathic pain.</p><p><strong>Results: </strong>Pre-surgery, all 11 autograft repair subjects suffered chronic neuropathic pain of 4-10 (mean 8.6±4.2), with 81.8% of 8-10. Following repairs, pain reduction started when axons started reinnervating targets. The pain decreased to 0-6 (mean 0.27 ± 0.3), with 18.2% having long-term pain reduction and 81.8% long-term pain elimination. Pre-surgery, of the 15 PRP repair subjects, 60% suffered chronic pain of 4-10 (mean 7.7 ± 1.4), with 66.7% pain of 8-10. Pain reduction began within two weeks, and within two months, 11% of the subjects had maximum pain reduction and 89% long-term pain elimination. The pain never increased or occurred over the following 1.1-15.4 years.</p><p><strong>Conclusion: </strong>Chronic neuropathic pain is normally reduced/eliminated when axons reinnervate targets, including by using targeted muscle reinnervation (TMR). However, bridging nerve gaps with an autograft within a PRP-filled collagen tube reduces/eliminates pain far faster because axon regeneration and target reinnervation are not required, only that platelet-released factors act on the peripheral axons. In addition, the PRP technique induces pain reduction several times greater than TMR, and although TMR is only effective when applied less than four months post-trauma, PRP is effective when applied at least up to 3.25 years post-trauma. This is the first clinical demonstration that PRP induces long-term pain reduction/elimination by factors acting only on peripheral axons, while they are regenerating and does not require target reinnervation. This study sets the stage for testing whether bridging gaps with only a PRP-filled collagen tube has the same effects.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3207-3216"},"PeriodicalIF":2.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Triptan Safety in Pediatric Migraine Management: A Comprehensive Pharmacovigilance Analysis.","authors":"Junchen Chen, Shunqiu Huang, Yashi Chen, Cheng Luo, Yong Li","doi":"10.2147/JPR.S524809","DOIUrl":"10.2147/JPR.S524809","url":null,"abstract":"<p><strong>Introduction: </strong>Triptans are the only FDA-approved migraine-specific treatment for pediatric patients, yet comprehensive real-world safety data remains limited, particularly regarding rare adverse events and age-specific safety profiles.</p><p><strong>Methods and materials: </strong>We conducted a pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS) database from 2004-2024, focusing on adverse events associated with sumatriptan, rizatriptan, zolmitriptan, and almotriptan in patients aged 6-18 years. After systematic deduplication following FDA guidelines, disproportionality analysis was performed using reporting odds ratios (ROR) and risk-signal detection ratios (RSDR). Subgroup analyses compared safety signals between children (6-11 years) and adolescents (12-18 years) at both Preferred Terms and System Organ Class levels.</p><p><strong>Results: </strong>Among 19,557 triptan-related cases in FAERS, 375 (1.9%) were pediatric cases, predominantly female (70.7%) and aged 12-18 years (91.2%). Sumatriptan was most frequently reported (77.3%), followed by rizatriptan (17.9%). Significant safety signals included posterior reversible encephalopathy syndrome with sumatriptan (ROR=86.69, 95% CI=26.6-282.54), acute respiratory failure with rizatriptan (ROR=98.12, 95% CI=40.17-239.64), and renal infarction with zolmitriptan (ROR=2231.93, 95% CI=667.65-7461.24). Age-stratified analysis revealed distinct profiles: younger children (6-11 years) showed higher risks for gastric emptying impairment (ROR=331.24) and throat tightness (ROR=77.14), while adolescents (12-18 years) experienced more diverse adverse events, notably pharyngeal swelling (ROR=133.81) and chest discomfort (ROR=19.05).</p><p><strong>Conclusion: </strong>Real-world triptan safety profiles reveal age-specific risks in pediatric populations, emphasizing the need for tailored monitoring strategies and age-appropriate safety protocols.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3185-3205"},"PeriodicalIF":2.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetics and Herbs: Potential Therapeutic Strategies for Osteoarthritis of the Knee.","authors":"Yihui Zheng, Jiahui Wang, Lei Wang, Yang Zheng, Wen Qi","doi":"10.2147/JPR.S517224","DOIUrl":"10.2147/JPR.S517224","url":null,"abstract":"<p><p>Knee osteoarthritis (KOA) is a complex joint disease characterized by progressive cartilage degeneration with programmed cell death of chondrocytes. Programmed cell death (PCD) of chondrocytes plays a central role in the development of knee osteoarthritis, and epigenetics provides new explanations for this complex biological process. By regulating DNA methylation, histone modification and non-coding RNA, epigenetic mechanisms can significantly affect chondrocyte survival and apoptosis without altering the gene sequence. Recent studies have found that TCM can intervene in the epigenetic regulatory network by targeting epigenetic enzymes with active ingredients, non-coding RNA-mediated co-regulation, and epigenetic-metabolic reprogramming. In this paper, we review the latest studies on epigenetics in chondrocyte programmed cell death, focusing on the mechanisms of DNA methylation, histone modification, and non-coding RNAs, such as miRNAs and lncRNAs, and also discuss the interventional roles of TCM in this process, providing therapeutic references to delve into the pathogenesis of KOA.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3217-3261"},"PeriodicalIF":2.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional and National Burden of Low Back Pain in Adolescents Aged 10-19 years, 1990-2021: A Systematic Analysis of the Global Burden of Disease Study 2021.","authors":"Shuang Wang, Shouyao Zhang, Min Li, Suyu Chen, Yiping Chen, Yongli Song, Xinghe Zhang","doi":"10.2147/JPR.S525330","DOIUrl":"10.2147/JPR.S525330","url":null,"abstract":"<p><strong>Objective: </strong>To comprehensively analyze the levels and trends of low back pain (LBP) prevalence, incidence, and years lived with disability (YLDs) among adolescents aged 10-19 globally from 1990 to 2021, stratified by sex and the Socio - Demographic Index (SDI), and analyze the risk factors.</p><p><strong>Summary of background data: </strong>LBP affects adolescents, but its global burden and trends among this age group need exploration.</p><p><strong>Methods: </strong>Estimations were carried out using the Bayesian meta-regression tool, DisMod-MR(Disease Modeling Meta-Regression) 2.1. The estimated annual percentage change (EAPC) was calculated based on the linear regression patterns of age-standardized rates and calendar years to represent the temporal trends of age-standardized rates. Data analysis and visualization were performed using the R software (version 4.2.2).</p><p><strong>Results: </strong>In 2021, global 10-19 years old had 38,476,826 (95% UI, 29,229,615-49,665,830) incident LBP cases, 19,234,452 (95% UI, 14,487,990-24,798,451) prevalent cases, and 4,205,995 (95% UI, 2,713,716-5,947,074) total YLDs. ASPR (Age-Standardized Prevalence Rate), ASIR (Age-Standardized Incidence Rate), ASYR (Age-Standardized YLDs Rate) declined. Females had higher rates. ASYR and SDI were positively correlated. Hungary, Czech Republic, Romania had high national prevalence; certain regions had big increases. Occupational risks were the only risk factor.</p><p><strong>Conclusion: </strong>LBP still causes high distress to adolescents aged 10-19 and seriously affects their physical and mental health. The burden of LBP remains high. It is necessary to increase the public and policymakers' awareness of its risk factors and take preventive measures to reduce the future burden of this disease.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3171-3183"},"PeriodicalIF":2.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Causal Effect of Pulse Pressure on Migraine Risk: A Mendelian Randomization Study.","authors":"Hongli Xu, Xiaoyan Qin, Zeguo Feng, Shaohua You","doi":"10.2147/JPR.S512795","DOIUrl":"10.2147/JPR.S512795","url":null,"abstract":"<p><strong>Background: </strong>Migraine is notably prevalent among young individuals and women, who generally demonstrate favorable arterial compliance. Pulse pressure is a reliable measure of arterial compliance; nevertheless, the association between pulse pressure and migraine is not well understood.</p><p><strong>Aim: </strong>To investigate the potential causal relationship between pulse pressure and the risk of migraine using Mendelian randomization (MR).</p><p><strong>Methods: </strong>The pulse pressure studies mainly involved participants of European descent, while the migraine studies included individuals from various parts of the UK. The primary analysis used Inverse Variance Weighted (IVW) method, supplemented by weighted median and MR-Egger regression. Validation data came from the FinnGen study. Genes linked to pulse pressure were analyzed for Gene Ontology (GO) and KEGG enrichment using the DAVID platform.</p><p><strong>Results: </strong>Single-nucleotide polymorphisms linked to pulse pressure were sourced from a GWAS database (810,865 individuals), while migraine data came from UK Biobank (13,971 cases, 470,627 controls). The IVW method showed an OR of 0.992 [95% confidence interval (CI), 0.987-0.997; <i>p =</i> 0.002]. Both weighted median (OR 0.988; 95% CI, 0.982-0.994; <i>p</i> < 0.001) and MR-Egger (OR 0.985; 95% CI, 0.972-0.997; <i>p =</i> 0.016) analyses confirmed a negative causal link between pulse pressure and migraine risk. The MR-Egger intercept analysis showed minimal evidence of horizontal pleiotropy (b = 0.00013, SE = 0.00010, <i>p =</i> 0.209). Finnish data confirmed a causal link between migraine and pulse pressure, with the IVW method indicating a significant association (OR = 0.790, 95% CI: 0.676-0.922; <i>p</i> = 0.003). KEGG enrichment analysis revealed significant pathways regulating pulse pressure, many related to cardiovascular disease and type 2 diabetes.</p><p><strong>Conclusion: </strong>MR analysis showed that pulse pressure causally affects migraines, potentially explaining why young people and women experience more migraines, while those with type 2 diabetes have a lower risk. Further research is needed to understand this relationship.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3159-3170"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypervigilance to Pain May Predict the Transition from Subacute to Chronic Back Pain: A Longitudinal Observational Study.","authors":"Wen Zhang, Martin Löffler, Katrin Usai, Mina Mišić, Frauke Nees, Herta Flor","doi":"10.2147/JPR.S512911","DOIUrl":"10.2147/JPR.S512911","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate whether incorporating additional psychological and social risk factors, beyond those captured by the Örebro Musculoskeletal Pain Questionnaire (ÖMPQ), could enhance the prediction of the transition from subacute to chronic back pain.</p><p><strong>Patients and methods: </strong>Data of 75 patients with subacute back pain (SABP, 7-12 weeks) from a longitudinal observational study were analyzed. The ÖMPQ and additional emotional, cognitive, behavioural, and social factors were assessed at baseline. Pain severity and pain-related interference were assessed at baseline and six months later to evaluate chronicity. Principal component analysis reduced psychological variables into interpretable components. Pearson's correlation examined relationships between psychological factors, pain severity, and pain interference at baseline and 6-month follow-up. Factors linked to pain persistence were identified using best subsets regression and tested in multistage linear regression: (1) without baseline adjustment, (2) with baseline adjustment, and (3) assessing the effect of predictors from the previous steps on 6-month outcomes.</p><p><strong>Results: </strong>The ÖMPQ and the Pain Vigilance and Awareness Questionnaire (PVAQ) scores significantly predicted pain severity, and the ÖMPQ, the Pain Behaviour Checklist (PBC), and PVAQ scores significantly predicted pain-related interference after six months. Multistage linear regression showed that PVAQ scores best predicted both pain severity (ß = 0.25, <i>p</i> = 0.017) and pain-related interference (ß = 0.33, <i>p</i> = 0.002) six months later, even after adjusting baseline pain levels.</p><p><strong>Conclusion: </strong>The ÖMPQ score initially predicted pain persistence at six months, but its effect diminished after adjusting for baseline pain levels. In contrast, psychological risk factors such as pain hypervigilance and pain behaviors emerged as predictors of the pain severity or pain-related interference at six months. Pain hypervigilance became the strongest predictor of both pain severity and pain-related interference, regardless of initial pain, suggesting it as a target for early intervention.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3141-3158"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}