Journal of Pain Research最新文献

{"title":"Assessing the Causal Effect of Pulse Pressure on Migraine Risk: A Mendelian Randomization Study.","authors":"Hongli Xu, Xiaoyan Qin, Zeguo Feng, Shaohua You","doi":"10.2147/JPR.S512795","DOIUrl":"10.2147/JPR.S512795","url":null,"abstract":"<p><strong>Background: </strong>Migraine is notably prevalent among young individuals and women, who generally demonstrate favorable arterial compliance. Pulse pressure is a reliable measure of arterial compliance; nevertheless, the association between pulse pressure and migraine is not well understood.</p><p><strong>Aim: </strong>To investigate the potential causal relationship between pulse pressure and the risk of migraine using Mendelian randomization (MR).</p><p><strong>Methods: </strong>The pulse pressure studies mainly involved participants of European descent, while the migraine studies included individuals from various parts of the UK. The primary analysis used Inverse Variance Weighted (IVW) method, supplemented by weighted median and MR-Egger regression. Validation data came from the FinnGen study. Genes linked to pulse pressure were analyzed for Gene Ontology (GO) and KEGG enrichment using the DAVID platform.</p><p><strong>Results: </strong>Single-nucleotide polymorphisms linked to pulse pressure were sourced from a GWAS database (810,865 individuals), while migraine data came from UK Biobank (13,971 cases, 470,627 controls). The IVW method showed an OR of 0.992 [95% confidence interval (CI), 0.987-0.997; <i>p =</i> 0.002]. Both weighted median (OR 0.988; 95% CI, 0.982-0.994; <i>p</i> < 0.001) and MR-Egger (OR 0.985; 95% CI, 0.972-0.997; <i>p =</i> 0.016) analyses confirmed a negative causal link between pulse pressure and migraine risk. The MR-Egger intercept analysis showed minimal evidence of horizontal pleiotropy (b = 0.00013, SE = 0.00010, <i>p =</i> 0.209). Finnish data confirmed a causal link between migraine and pulse pressure, with the IVW method indicating a significant association (OR = 0.790, 95% CI: 0.676-0.922; <i>p</i> = 0.003). KEGG enrichment analysis revealed significant pathways regulating pulse pressure, many related to cardiovascular disease and type 2 diabetes.</p><p><strong>Conclusion: </strong>MR analysis showed that pulse pressure causally affects migraines, potentially explaining why young people and women experience more migraines, while those with type 2 diabetes have a lower risk. Further research is needed to understand this relationship.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3159-3170"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypervigilance to Pain May Predict the Transition from Subacute to Chronic Back Pain: A Longitudinal Observational Study.","authors":"Wen Zhang, Martin Löffler, Katrin Usai, Mina Mišić, Frauke Nees, Herta Flor","doi":"10.2147/JPR.S512911","DOIUrl":"10.2147/JPR.S512911","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate whether incorporating additional psychological and social risk factors, beyond those captured by the Örebro Musculoskeletal Pain Questionnaire (ÖMPQ), could enhance the prediction of the transition from subacute to chronic back pain.</p><p><strong>Patients and methods: </strong>Data of 75 patients with subacute back pain (SABP, 7-12 weeks) from a longitudinal observational study were analyzed. The ÖMPQ and additional emotional, cognitive, behavioural, and social factors were assessed at baseline. Pain severity and pain-related interference were assessed at baseline and six months later to evaluate chronicity. Principal component analysis reduced psychological variables into interpretable components. Pearson's correlation examined relationships between psychological factors, pain severity, and pain interference at baseline and 6-month follow-up. Factors linked to pain persistence were identified using best subsets regression and tested in multistage linear regression: (1) without baseline adjustment, (2) with baseline adjustment, and (3) assessing the effect of predictors from the previous steps on 6-month outcomes.</p><p><strong>Results: </strong>The ÖMPQ and the Pain Vigilance and Awareness Questionnaire (PVAQ) scores significantly predicted pain severity, and the ÖMPQ, the Pain Behaviour Checklist (PBC), and PVAQ scores significantly predicted pain-related interference after six months. Multistage linear regression showed that PVAQ scores best predicted both pain severity (ß = 0.25, <i>p</i> = 0.017) and pain-related interference (ß = 0.33, <i>p</i> = 0.002) six months later, even after adjusting baseline pain levels.</p><p><strong>Conclusion: </strong>The ÖMPQ score initially predicted pain persistence at six months, but its effect diminished after adjusting for baseline pain levels. In contrast, psychological risk factors such as pain hypervigilance and pain behaviors emerged as predictors of the pain severity or pain-related interference at six months. Pain hypervigilance became the strongest predictor of both pain severity and pain-related interference, regardless of initial pain, suggesting it as a target for early intervention.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3141-3158"},"PeriodicalIF":2.5,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Guidelines from the American Society of Pain and Neuroscience for the Use of 60-Day Peripheral Nerve Stimulation Therapy. A NEURON Living Guideline Project.","authors":"Benjamin Gill, Cody Tidwell, Jonathan M Hagedorn, Alexandra M Moreira, Marco Lawandy, Benjamin Boyett, Justin Schappell, Usman Latif, Scott Pritzlaff, Ioannis Skaribas, Hemant Kalia, Samir Sheth, Maricela Schnur, Sean Li, Denise Lester, Trevor Ellico, Ramana Naidu, David Russo, Christopher Massey, Einar Ottestad, Kevin Vorenkamp, Henry Vucetic, Matthew J Pingree, David Abejón, Mehul J Desai, David Dickerson, Amitabh Gulati, Dawood Sayed, Timothy R Deer","doi":"10.2147/JPR.S521788","DOIUrl":"10.2147/JPR.S521788","url":null,"abstract":"<p><p>Peripheral nerve stimulation (PNS) has evolved with various applications and durations of therapy. In recent years, extensive data has been developed on a 60-day treatment using a novel approach. Confusion exists on the use of a trial therapy, a permanent implant, and a 60-day duration treatment. The American Society of Pain and Neuroscience (ASPN) seeks to clarify the literature associated with this neuromodulation approach. A diverse group of experts was nominated to provide opinions and guidance based on evidence-graded assessment and clinical knowledge. This guidance is the first to specifically assess the clinical use of 60-day PNS and best medical practice.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3117-3139"},"PeriodicalIF":2.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Physician Knowledge of Data Privacy and Cybersecurity Risks in Neuromodulation: An Online Cross-Sectional Survey.","authors":"Everette Martin, Erika Petersen, Jarna R Shah","doi":"10.2147/JPR.S506509","DOIUrl":"10.2147/JPR.S506509","url":null,"abstract":"<p><strong>Purpose: </strong>Data privacy and cybersecurity should both be seriously considered for all devices that interact with our patients. There is little education of patients and clinicians about the cybersecurity and privacy of implanted medical devices, and these considerations are likely not part of informed consent discussions. The FDA has made efforts to remedy this, including releasing suggestions on how best to counsel patients and updating industry cybersecurity considerations, however they are not currently legally binding.</p><p><strong>Participants and methods: </strong>In this online survey, we assess the awareness, understanding, and interest of clinicians implanting neuromodulation devices in the topics of cybersecurity and device privacy.</p><p><strong>Results: </strong>Clinicians were limited in their familiarity and awareness of these topics. The majority of responders do not counsel their patients on device cybersecurity and only sometimes counsel them on data privacy.</p><p><strong>Conclusion: </strong>Patients and providers may have limited knowledge of data privacy and cybersecurity in implanted medical devices and further education should be undertaken to promote the impact of these issues.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3101-3106"},"PeriodicalIF":2.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Correlation Between Gastroesophageal Reflux Disease and Chronic Widespread Pain: A Bidirectional Mendelian Randomization Study.","authors":"Menglin Chen, Houshu Tu, Jiaoli Zhou, Yi Zhang, Shuting Wen, Yao Xiao, Ling He","doi":"10.2147/JPR.S494166","DOIUrl":"10.2147/JPR.S494166","url":null,"abstract":"<p><strong>Background: </strong>Previous observational research found a relationship between gastroesophageal reflux disease (GERD) and chronic widespread pain (CWP). Despite this, it is unknown which, if any, of the conditions produces the other. Our study will use bidirectional Mendelian randomization (MR) to evaluate their causal link.</p><p><strong>Methods: </strong>We examined two sets of publically accessible data from genome-wide association studies (GWAS): GERD (129,080 cases and 602,604 controls) and CWP (6,914 cases and 242,929 controls). We used the inverse variance weighting (IVW) approach as the major analysis method, but we also ran weighted median and MR-Egger regression analyses. We performed various sensitivity studies to assess the conclusions' consistency, horizontal pleiotropy, and stability.</p><p><strong>Results: </strong>MR analysis showed that CWP increased the risk of developing GERD [N_SNP = 4, odds ratio (OR): 245.244; 95% confidence interval (CI): 4.35E+00,1.38E+04; <i>p</i> =0.007 < 0.05] and vice versa (N_SNP = 28; OR:1.019; 95% CI: 1.009-1.029; <i>p</i> = 0.029 < 0.05). Bidirectional evidence of causality existed. The sensitivity analysis demonstrated the robustness and reliability of the findings.</p><p><strong>Conclusion: </strong>Our study demonstrated a bidirectional causal relationship between GERD and chronic widespread pain, and future interventions for CWP may be an effective strategy for preventing or mitigating GERD and vice versa.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3107-3115"},"PeriodicalIF":2.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Combination of Thunder Fire Moxibustion with Other Forms of Traditional Chinese Medicine for Osteoarthritis Knee: A Meta-Analysis.","authors":"Wei Wei, Yeyu Qin, Jie Lin","doi":"10.2147/JPR.S502457","DOIUrl":"10.2147/JPR.S502457","url":null,"abstract":"<p><strong>Background: </strong>Given the prevalence of osteoarthritis and the growing interest in alternative treatments, there is a need to provide a comprehensive evaluation of this integrated TCM approach. Reviews are required to understand the potential benefits and safety of the combination therapy compared to conventional treatments. Hence, this meta-analysis investigates the effectiveness of combining Thunder Fire Moxibustion with other Traditional Chinese Medicine (TCM) modalities, specifically acupuncture and herbal formulas, in treating knee osteoarthritis.</p><p><strong>Methods: </strong>A comprehensive literature search across databases like PubMed Central, EMBASE, MEDLINE, and others was conducted. The inclusion criteria focused on randomized controlled trials involving patients with knee osteoarthritis, comparing the effectiveness of Thunder Fire Moxibustion combined with other TCM modalities against standard care. The Cochrane Risk of Bias tool was used for bias assessment, and a random-effects inverse-variance model for meta-analysis.</p><p><strong>Results: </strong>Out of 1467 records, 7 studies met the inclusion criteria. The pooled Risk Ratio (RR) for total effective rate was 1.119, indicating a significant effect of the combined TCM treatment. Subgroup analysis showed a pooled RR of 1.130 for acupuncture combinations and 1.103 for herbal TCM combinations. The incidence of adverse reactions had a non-significant pooled RR of 0.572. The GRADE assessment indicated a low overall quality of evidence due to risks of bias and publication bias.</p><p><strong>Conclusion: </strong>The combination of Thunder Fire Moxibustion with other TCM modalities shows potential effectiveness in treating knee osteoarthritis, with minimal adverse reactions. However, the low quality of evidence suggests a need for more rigorous studies to confirm these findings.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3087-3099"},"PeriodicalIF":2.5,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT Angiographic Evaluation of Superior Gluteal Artery Branches in Lateral Sacroiliac Joint Fusion: A Pilot Study to Inform Preoperative Surgical Planning and Anatomic Parameters.","authors":"Christopher J Mallard, Michael E Harned, Jay S Grider","doi":"10.2147/JPR.S514778","DOIUrl":"10.2147/JPR.S514778","url":null,"abstract":"<p><strong>Introduction: </strong>The sacroiliac (SI) joint can be a source of low back pain. Surgical techniques for fusion include lateral transiliac, posterolateral, sacro-alar iliac and posterior interpositional fixations. Although these various trajectories are supported by the literature, the lateral transiliac approach is the most extensively studied. However, this technique has been associated with concern for potential injury to branches of the superior gluteal artery (SGA). Currently, no preoperative workup includes the evaluation of SGA and its branches for location and potential injury during lateral fusion. We propose a clinical pathway for the identification and risk stratification of SGA injuries using preoperative CT of the pelvic vasculature and measurements of the proposed transiliac screw sites.</p><p><strong>Purpose: </strong>To determine whether preprocedural CT angiography (CTA) can identify the course of the SGA and its branches in relation to planned lateral transiliac SI joint fusion trajectories, thereby informing surgical planning and potentially reducing vascular risk.</p><p><strong>Patients and methods: </strong>Twenty patients underwent preoperative CTA. Angiographic images were processed to generate a 3D vascular reconstruction. The proposed screw locations were identified, measured, and analyzed using descriptive statistics.</p><p><strong>Results: </strong>20 patients' images were analyzed with the average distance to the nearest SGA branch on the right being 19.0 mm ± 9.4 mm (minimum distance 5.75mm) and 17.3 mm ± 7.9 mm (minimum distance 5.97mm) on the left. Screw placement was altered in 1 of the 10 patients with an average total estimated blood loss (EBL) of 6.5mL ± 2.4mL in surgical patients.</p><p><strong>Conclusion: </strong>This pilot study suggests that preoperative CTA may aid proceduralists in planning lateral transiliac sacroiliac joint fusion by identifying the course of the SGA and its branches, potentially reducing the risk of vascular injury.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3069-3075"},"PeriodicalIF":2.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Role of Depression in the Relationship Between Perceived Injustice and Pain Intensity Among Fibromyalgia Patients.","authors":"Sheer Raev, Valerie Aloush, Gadi Gilam, Odelia Elkana","doi":"10.2147/JPR.S518357","DOIUrl":"10.2147/JPR.S518357","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia (FM) patients often perceive heightened levels of injustice, which can be associated with depressive symptoms. Despite this connection, the mediating role of depression between perceived injustice and pain intensity in FM patients remains unexplored.</p><p><strong>Aim: </strong>This study explored whether depression mediates the relationship between perceived injustice and pain intensity in FM.</p><p><strong>Methods: </strong>Data were collected through an online survey distributed to FM patients at the Tel Aviv Sourasky Medical Center, Israel. A total of 161 FM patients completed the survey, with perceived injustice assessed using the Injustice Experience Questionnaire, depression evaluated using the Patient Health Questionnaire, and pain intensity measured with the numerical Pain Intensity Rating Scale. Statistical analyses included analysis of variance and bootstrap-based mediation models.</p><p><strong>Results: </strong>FM patients reported elevated levels of pain, perceived injustice, and depression. The study found that depression significantly mediated the association between perceived injustice and pain intensity in FM patients (P < 0.001, CI = 0.024, 0.312).</p><p><strong>Conclusion: </strong>The link between perceived injustice and pain intensity in FM is partially explained by the level of depression. Individuals with higher perceived injustice scores are more susceptible to depression, subsequently experiencing increased pain. These findings suggest that intervention programs targeting depression may mitigate the impact of perceived injustice on pain intensity in FM, potentially enhancing health-related quality of life.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3077-3085"},"PeriodicalIF":2.5,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Application Rules and Clinical Significance of Acupoints in Acupuncture Treatment of Migraine Based on Data Mining.","authors":"Yujun He, Xiaoyi Wang, Minhui Liu, Lu Li, Tingfen Han, Yachao Wu, Xiaojun Li","doi":"10.2147/JPR.S527987","DOIUrl":"10.2147/JPR.S527987","url":null,"abstract":"<p><strong>Background: </strong>Abundant clinical investigations have attested to the efficacy of acupuncture in treating migraines. However, as each acupoint elicits distinct analgesic pathways and acupuncturists vary in their acupoint selection, there is currently an absence of evidence-based guidance for determining the optimal acupoint selection.</p><p><strong>Objective: </strong>The aim of this study was to conduct an initial comprehensive data mining analysis to identify the most effective acupoints and their combinations for migraine treatment.</p><p><strong>Methods: </strong>A comprehensive search was carried out in eight electronic bibliographic databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chongqing VIP Database) from their inception up to May 2025. Studies evaluating the effectiveness of acupuncture in treating migraines were selected. The literature was rigorously evaluated according to predefined inclusion and exclusion criteria, and relevant data were then extracted for analysis. Excel 2021 was used for descriptive statistical analysis. Association rule analysis was performed using SPSS Modeler 14.1. Exploratory factor analysis, cluster analysis, and decision tree analysis were conducted using SPSS Statistics 26.0.</p><p><strong>Results: </strong>A total of 911 trials were identified, from which 1610 groups of effective prescriptions involving 181 acupoints were extracted. The most commonly used acupoints were Feng-chi (GB20), Tai-yang (EX-HN5), Shuai-gu (GB8), Bai-hui (GV20), and He-gu (LI4). The gallbladder meridian was the most frequently utilized meridian. Specific points, mainly crossing points, were predominantly used, with head and neck acupoints being the most common. The combination of \"Feng-chi (GB20), Tai-yang (EX-HN5), and Shuai-gu (GB8)\" was frequently used as the core acupoints group. Additionally, several acupoint combinations were obtained through exploratory factor analysis, cluster analysis, and decision tree analysis.</p><p><strong>Conclusion: </strong>This research provides evidence-based support for the effectiveness of acupoint selection in migraine treatment and offers potential therapeutic recommendations, thereby facilitating collaborative decision-making between healthcare providers and patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3049-3067"},"PeriodicalIF":2.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupotomy for Musculoskeletal Pain: Exploring Therapeutic Potential and Future Directions.","authors":"Jiatong Hu, Hongxuan Tong, Jiale Zhang, Lijie Jiang","doi":"10.2147/JPR.S518705","DOIUrl":"10.2147/JPR.S518705","url":null,"abstract":"<p><p>Musculoskeletal pain imposes a significant burden due to its high prevalence and complex pathophysiology. This perspective paper examines the current knowledge regarding the underlying mechanisms of musculoskeletal pain conditions and explores the therapeutic potential of acupotomy. Preliminary evidence suggests that acupotomy holds promise in effectively alleviating pain, improving functional outcomes, and facilitating myofascial tissue healing in individuals with musculoskeletal pain. However, further studies are warranted to elucidate the precise mechanisms through which acupotomy modulates fascia and trigger points, thus influencing pain processing. The targeted and precise nature of acupotomy in addressing specific trigger points and promoting tissue healing offers a promising approach for managing musculoskeletal pain. Nevertheless, additional research is imperative to comprehensively understand its mechanisms of action and optimize treatment protocols. This perspective paper critically contributes valuable insights into the contemporary understanding of musculoskeletal pain and underscores the potential of acupotomy as a valuable treatment modality.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3027-3036"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}