Journal of Pain Research最新文献

{"title":"Research on the Developmental Trajectory of Movement-Evoked Pain and Its Potential Predictors in Patients After Knee Arthroplasty.","authors":"Shanshan Ai, Sumin Zhao, Lihui Yan, Hangying Hu, Pengli Niu, Yueli Zhu, Meifang Zheng","doi":"10.2147/JPR.S510554","DOIUrl":"https://doi.org/10.2147/JPR.S510554","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the developmental trajectory of movement-evoked pain after knee arthroplasty and analyze the predictors of different developmental trajectory categories.</p><p><strong>Patients and methods: </strong>In this study, a total of 178 patients undergoing knee arthroplasty were recruited from the Department of Joint Surgery at a tertiary care hospital in China. Participants completed the General Data Questionnaire, the Social Support Revaluated Scale, and the Pain Catastrophizing Scale on the day before surgery (T1). Movement-evoked pain was assessed using the Pain Numerical Rating Scale at 24 hours (T2), 48 hours (T3), and 72 hours (T4) after knee arthroplasty. The growth mixture model was utilized to identify the developmental trajectories of movement-evoked pain after knee arthroplasty.</p><p><strong>Results: </strong>Three developmental trajectories of movement-evoked pain after knee arthroplasty were identified: the moderate pain-rise then decline group (47.75%), the moderate pain-continuous decline group (11.80%), and the severe pain-continuous stable group (40.45%). Multivariate logistic regression analysis indicated that social support, pain catastrophization, education, disease duration, and operation time were significant predictors of the types of movement-evoked pain in knee arthroplasty patients (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>This study identifies three potential categories of movement-evoked pain developmental trajectories after knee arthroplasty, with the moderate pain-rising then falling group being the most common. Significant predictors include social support, pain catastrophization, education, disease duration, and operation time.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2127-2136"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Clinical Symptoms of Unilateral S1 Nerve Injury Caused by Disc Herniation the via High Resolution MRI and DTI.","authors":"ChaoYang Zhang, Wei Hao, Xiaobo Guo, Yuna Zhang, Hao Fu, Jiashan Zhang","doi":"10.2147/JPR.S507867","DOIUrl":"https://doi.org/10.2147/JPR.S507867","url":null,"abstract":"<p><strong>Background: </strong>The status of the herniated disc or nucleus pulposus and the extent of injury and clinical symptoms of the compressed S1 nerve fiber bundle were evaluated by high-resolution Magnetic resonance imaging (MRI) and Diffusion tensor imaging (DTI) techniques.</p><p><strong>Methods: </strong>Forty-two clinically proven patients with unilateral S1 nerve root compression were selected as the case group (n=42), and 20 healthy volunteers were selected as the control group (n=20). The general data, MRI features and DTI parameters were compared between groups. The effective indicators of S1 neurologic fiber bundle damage were screened by univariate logistic regression analysis and receiver operating characteristic (ROC) curve, and multi-factor logistic regression models were constructed to analyze the diagnostic efficiency of each model.</p><p><strong>Results: </strong>There were no significant differences in age, gender, height, weight, fractional anisotropy (FA) value and apparent diffusion coefficient (ADC) value on both sides of S1 nerve root between groups (P >0.05). The FA value and ADC value of the nerve root on the affected side of the patient were significantly different from those on the healthy side and those on the corresponding side of the control group (all P <0.05), and all of them were effective indicators of the damage of S1 nerve. The sensitivity, specificity and area under the curve of the damaged nerve fiber bundle were detected by multi-factor logistic regression models constructed with FA+rFA and FA+rFA+rADC of the affected nerve root, respectively 95.20%, 72.00%, 0.939, and 97.60%, 80.00%, 0.944.</p><p><strong>Conclusion: </strong>High-resolution MRI and DTI can quantitatively evaluate the degree of nerve fiber bundle injury and clinical symptoms caused by lumbar disc herniation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2105-2114"},"PeriodicalIF":2.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Multifactorial Predictors of Pain in Chronic Musculoskeletal Pain: A Regression-Based Study.","authors":"Angel González-de-la-Flor, María Bravo-Aguilar, Jaime Almazán-Polo, Guillermo García-Pérez-de-Sevilla, Pedro Martínez-Lozano, Carlos Romero-Morales","doi":"10.2147/JPR.S500636","DOIUrl":"https://doi.org/10.2147/JPR.S500636","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess differences in pain neurophysiology knowledge between individuals with chronic musculoskeletal pain (CMP) and those without CMP, and to explore associations between pain knowledge, pain intensity, and demographic and lifestyle factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 171 participants, including 120 with CMP and 51 without CMP. Sociodemographic, pain-related, and lifestyle data were collected. Pain knowledge was assessed using the Revised Neurophysiology of Pain Questionnaire (R-NPQ). Statistical analyses included t-tests, chi-squared tests, Pearson's correlation, and stepwise regression models to identify predictors of pain intensity and CMP presence.</p><p><strong>Results: </strong>Significant differences were found between participants with and without CMP in BMI (p<0.001), physical activity (p=0.023), education level (p=0.002), and alcohol consumption (p=0.017). Participants with CMP scored lower on the R-NPQ (mean 4.40 ± 2.1) than those without CMP (mean 6.31 ± 2.03; p<0.001). Pain intensity was negatively associated with R-NPQ scores (r=-0.315; p<0.001), physical activity (r=-0.199; p=0.030), and education level (rho=0.236; p=0.010). Stepwise regression analysis revealed that R-NPQ scores (20.7%), BMI (6.7%), education level (3.9%), and physical activity (2.6%) collectively explained 33.9% of the variance in pain intensity (adjusted R²=0.339). Binary logistic regression identified BMI, R-NPQ scores, and education level as significant predictors of CMP presence, with higher BMI and lower R-NPQ scores increasing the odds of CMP, while higher education levels and physical activity were predictive factors.</p><p><strong>Conclusion: </strong>Individuals with CMP exhibited lower knowledge of pain neurophysiology, higher BMI, reduced physical activity levels, and lower educational attainment, all of which were associated with increased pain intensity and a greater likelihood of CMP presence.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2081-2091"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Endoscopic Backhand Holding (EBH) Technique for Extraforaminal Lumbar Disc Herniations: A Modified Operative Technique.","authors":"Meng Kong, Changtong Gao, Meng Hao, Xuexiao Ma, Jindong Zhao, Jian Luan, Yong Lin, Canghai Jin, Qiang Li","doi":"10.2147/JPR.S498090","DOIUrl":"https://doi.org/10.2147/JPR.S498090","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous endoscopic lumbar discectomy (PELD) is a minimally invasive surgical (MIS) procedure rapidly improved in the surgical treatment of lumbar disc herniation (LDH). For the treatment of extraforaminal lumbar disc herniations (ELDH), microendoscopic discectomy (MED) or traditional Transforaminal Lumbar Interbody Fusion (MIS-TLIF) are commonly used, but limitations exist due to bony resection. Many classic surgical approaches for PELD have inherent disadvantage when removing migrated ELDH.</p><p><strong>Objective: </strong>We aimed to present the results of a series of PELD cases that were operated using a modified endoscopic backhand holding (EBH) approach for the treatment of ELDH.</p><p><strong>Methods: </strong>Seventy-two patients diagnosed with ELDH who underwent PELD via the EBH approach from January 2018 to December 2022 were retrospectively assessed. Pre- and postoperative clinical data, radiographic findings, and surgical techniques were investigated. Neurological recovery examinations were performed preoperatively and at 3 days, 1 month, 3 months, 6 months, 1 year postoperatively.</p><p><strong>Results: </strong>No major intraoperative complications were noted. Significant improvement in back and leg pain was observed in visual analogue scale (VAS) score, and the mean ODI was decreased from preoperative 78% (range = 60-98%) to postoperative 30% (20-40%) (<i>P</i> < 0.001) at 1-month follow-up and obtained further improvement at 1 year (mean ODI = 11%; range = 2-20%). All patients showed progressive improvement in their initial neurological deficits, with complete recovery of motor weakness. According to the Macnab criteria, overall excellent and good outcomes were obtained in 67 patients (95.7%) - 57 excellent (81.4%), and 10 (14.3%) good - with fair outcomes in three patients (4.3%) at the time of last follow-up.</p><p><strong>Conclusion: </strong>Percutaneous endoscopic backhand holding is a minimally invasive, safe, valuable, and efficacious surgical procedure for treating ELDH. It is important that surgeons perform PELD using the technique they know best to ensure successful implementation of the surgery.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2069-2080"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine Headache and Its Related Disability Factors Among University Students in Jordan: A Cross-Sectional Study.","authors":"Miral A Almomani, Basima A Almomani, Nour A Al-Sawalha, Ahmad A Alqudah","doi":"10.2147/JPR.S504602","DOIUrl":"https://doi.org/10.2147/JPR.S504602","url":null,"abstract":"<p><strong>Introduction: </strong>Headache is a common complaint in medical practice that affects daily activity and quality of life. University students, especially, face psychological and academic stressors that may trigger migraine, leading to functional impairment. This can hinder concentration, studying, and academic performance, resulting in disability, reduced productivity, and absenteeism. Understanding the factors contributing to headache-related disability in Jordanian students is essential for improving mental health and guiding policies to promote academic success and overall well-being.</p><p><strong>Aim: </strong>The purpose of this study was to investigate the prevalence, features, and determinants of migraine headache-related disability among university students in Jordan.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among university students in Jordan. An online questionnaire was distributed using social media. A convenient sample of students from different universities across geographical areas in Jordan was invited to participate in the study.</p><p><strong>Results: </strong>Out of 1276 recruited participants, 64.97% of them have a history of headache in the previous 3 months. Of those, 80.22% probably have a diagnosis of migraine headache and 46% of them have an aura. Photophobia was the most common associated symptom (~90%) and sleep disturbance was the most reported factor trigger migraine attacks (83%). Most of the participants (82%) used analgesic medications, mainly OTC drugs (66.8%). Students with severe migraine intensity were more likely to have moderate-severe disability than those with mild/moderate intensity (OR = 1.69, 95 CI% = 1.23-2.34, p value = 0.001). In addition, the presence of an aura was associated with moderate-severe disability (OR = 1.57, 95 CI% = 1.14-2.16, p value = 0.006).</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of migraine headache among university students in Jordan, with photophobia and sleep disturbances identified as common triggers. The findings suggest that students with severe migraine intensity and those experiencing aura are more likely to face moderate-to-severe disability. The widespread use of analgesic medications, particularly over-the-counter drugs, underscores the need for targeted interventions to manage migraine symptoms and enhance the quality of life for affected students.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2093-2104"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suzetrigine: Is This What We Have Been Waiting for or Just the Beginning?","authors":"Christopher L Robinson, Michael E Schatman, Jamal Hasoon, Matthew Chung, Trent Emerick, Giuliano Lo Bianco, Sait Ashina, R Jason Yong","doi":"10.2147/JPR.S527710","DOIUrl":"https://doi.org/10.2147/JPR.S527710","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2047-2049"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study.","authors":"Liuxuan He, Ruizhu Zhou, Shuai Hou, Dan Huang, Xiaoxiao Zhao, Miaomiao Wang, Mengying Huang, Tao Yin, Haiyan Yin, Shuguang Yu","doi":"10.2147/JPR.S505312","DOIUrl":"https://doi.org/10.2147/JPR.S505312","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture and moxibustion, as traditional therapies in Chinese medicine, are widely recognized for their therapeutic effects, particularly in pain relief. Nevertheless, the exact mechanisms underlying their analgesic effects remain to be fully elucidated. Advancements in neuroimaging techniques have opened a novel pathway for investigating alterations in brain function resulting from acupuncture and moxibustion analgesia.</p><p><strong>Purpose: </strong>The purpose of this study was to investigate the brain regions activated during acupuncture and moxibustion treatment for pathological pain using neuroimaging, to better understand the underlying analgesic mechanisms.</p><p><strong>Patients and methods: </strong>An electronic search of PubMed was conducted using the keywords \"acupuncture\", \"moxibustion\", \"analgesia\", and \"neuroimaging\". A total of 37 articles, focusing on 14 diseases, were identified and analyzed.</p><p><strong>Results: </strong>Acupuncture primarily activated regions in the frontal, parietal, and temporal lobes, with key areas including the anterior cingulate cortex (ACC), insula, prefrontal cortex (PFC), and primary somatosensory cortex (S1). Different stimulation modes and disease types produced distinct patterns of brain region activation.</p><p><strong>Conclusion: </strong>Acupuncture and moxibustion modulate key brain regions involved in pain perception, emotional regulation, and cognitive functions. Acupuncture predominantly affects the sensory cortex, enhancing pain perception, while moxibustion has a more pronounced effect on the limbic system and thalamus, influencing emotional and cognitive aspects of pain. The findings indicate that acupuncture and moxibustion serve as effective non-pharmacological therapies for pain management, offering valuable insights into their underlying analgesic mechanisms. Future research should focus on further elucidating these mechanisms and optimizing clinical applications.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2051-2067"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual Therapy for Cervical Radiculopathy: Effects on Neck Disability and Pain - A Systematic Review and Network Meta-Analysis.","authors":"Xueliang Xu, Yan Ling","doi":"10.2147/JPR.S513428","DOIUrl":"https://doi.org/10.2147/JPR.S513428","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the application effects of different manual therapy approaches in the treatment of cervical radiculopathy using a network meta-analysis.</p><p><strong>Methods: </strong>Prospective randomized controlled trials on manual therapy for cervical radiculopathy published in PubMed, the Cochrane Library, and Embase databases were retrieved. The neck disability index and visual analogue scale for neck pain were collected and subjected to network meta-analysis.</p><p><strong>Results: </strong>A total of 8 eligible studies involving 632 participants with a mean age range of 40-47 years were included. The intervention duration ranged from 4 to 6 weeks. Three intervention groups were defined: Group C (exercise and other therapies without manual therapy), Group M (manual therapy without traction), and Group MT (manual therapy with traction). Larger circles indicate more patients, and thicker lines show more studies comparing interventions. Group M had the highest probability (68.1%) of improving the neck disability index, followed by Group MT (29.1%), with Group C the lowest (2.8%). Compared to Group C, neck disability index scores improved by 0.58 (95% CI: -0.17, 1.33) in Group M and by 0.36 (95% CI: -0.39, 1.11) in Group MT. The difference between Group M and Group MT was not significant (0.22, 95% CI: -0.59, 1.03). For neck pain (visual analogue scale score), Group M had the highest probability (59.5%) of improvement, followed by Group MT (39.6%), with Group C the lowest (0.9%). Compared to Group C, the visual analogue scale score improved by 0.74 (95% CI: -0.04, 1.52) in Group M and by 0.61 (95% CI: -0.18, 1.40) in Group MT. The difference between Group M and Group MT was not significant (0.13, 95% CI: -0.72, 0.98). Egger's regression test showed no apparent publication bias.</p><p><strong>Conclusion: </strong>Manual therapy is an effective approach for improving neck pain and neck disability index in patients with cervical radiculopathy, but more evidence-based support is needed regarding the use of cervical traction.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2035-2045"},"PeriodicalIF":2.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Impact of a Low-Carbohydrate Diet on The Chronic Pain Experience Among Adults with an Acquired Limb Loss: A Pilot Study.","authors":"Asia M Wiggins, Paige M Benlolo, Sunil V Suresh, Nathaniel M Goldfeiz, Conley J Carr, Robert E Sorge","doi":"10.2147/JPR.S507742","DOIUrl":"https://doi.org/10.2147/JPR.S507742","url":null,"abstract":"<p><strong>Purpose: </strong>Acquired limb loss can be a traumatic experience that is often accompanied by chronic pain (ie, phantom limb pain (PLP) and/or residual limb pain (RLP)) and can cause a reduction in emotional well-being and overall quality of life. Although, there are available treatments for PLP/RLP, few provide long-term relief. Therefore, the purpose of this study was to investigate the potential benefits of diet on reported pain and quality of life measures among adults with acquired limb loss.</p><p><strong>Methods: </strong>Seven adults with acquired limb loss (M = 50.57, SD ± 13.63 years of age) were enrolled in a 6-week low-carbohydrate diet (LCD) intervention. Baseline, 3-week, and 6-week measures of pain sensitivity (BPI, NPQ), cognitive flexibility (CFS), depression (CES-D, PROMIS-57), anxiety (PROMIS-57), pain resilience (PRS), and overall quality of life (SF-36) were obtained using validated questionnaires.</p><p><strong>Results: </strong>On average, all participants had appreciable levels of depression (M = 18.71, SD ± 6.16) and anxiety (M = 19.71, SD ± 5.94), yet relatively high levels of pain resilience (M = 44.42, SD ± 6.70) at baseline. After 6 weeks, participants showed improvements in self-reported measures of pain severity, emotional well-being, and other psychosocial measures of interest, including depression and anxiety.</p><p><strong>Conclusion: </strong>These results suggest that an LCD might have an influence on multiple chronic pain-related factors among adults living with an amputation. Furthermore, adults living with chronic PLP/RLP may report high resilience, although high levels of depression and anxiety are also reported.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2025-2034"},"PeriodicalIF":2.5,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.","authors":"Yunxuan Ma, Tingyao Hu, Naigang Liu, Changqing Guo, Longfei Xing, Weiwei Ma, Yongqi Cui, Xilin Chen","doi":"10.2147/JPR.S475829","DOIUrl":"https://doi.org/10.2147/JPR.S475829","url":null,"abstract":"<p><strong>Purpose: </strong>Premature senescence of chondrocytes is a typical lesion of knee osteoarthritis (KOA). Abnormal cartilage stress can inhibit the mechanosensitive Yes-associated protein (YAP) / transcription factor forkhead box D1 (FOXD1) pathway, which is related to premature senescence of chondrocytes, thereby accelerating the progression of the lesion. This study aims to investigate whether acupotomy intervention could inhibit the premature senescence of chondrocytes and protect the cartilage of KOA rabbits.</p><p><strong>Methods: </strong>18 male New Zealand rabbits were randomly divided into 3 groups (n = 6 each): control, KOA, and KOA + acupotomy (KOA+Apo). KOA, KOA+Apo rabbits were modeled by modified Videman's method for 6 weeks. After modeling, the KOA+Apo groups were subjected to acupotomy once a week for 3 weeks on the muscles around the left hind knee. The modified Lequesne MG score and passive range of motion (PROM) were used to evaluate the general condition and exercise ability of rabbits. Cartilage degeneration was detected by safranin O-fast green staining and transmission electron microscope(TEM). Type II collagen (Col-II) and aggrecan by immunohistochemistry (IHC), IL-7 and MMP-13 by Enzyme-Linked Immunosorbent Assay (ELISA), and p53, Rb1, p - YAP, YAP, FOXD1 by IHC, Western blot, or RT - PCR.</p><p><strong>Results: </strong>Acupotomy effectively curbed cartilage degeneration and chondrocyte premature senescence in KOA rabbits. Mechanistically, it cut IL - 7 and MMP-13 levels, easing the inflammatory milieu and extracellular matrix degradation. It also regulated p53 and Rb1, controlling cell - cycle progression. Crucially, acupotomy upregulated the YAP/FOXD1 pathway, which, by affecting downstream genes, modulated IL - 7, MMP-13, p53, and Rb1 levels, acting as a pivotal molecular link in its regulatory effects.</p><p><strong>Conclusion: </strong>Acupotomy may protect KOA rabbits' cartilage by inhibiting chondrocytes premature senescence via the YAP/FOXD1 pathway, offering a new theoretical basis for treating mechanically - induced KOA.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2011-2023"},"PeriodicalIF":2.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}