Journal of Pain Research最新文献

{"title":"Transcutaneous Electrical Acupoint Stimulation (TEAS) Facilitates Postoperative Recovery in Day Lung Cancer Surgery: A Randomized Controlled Trial.","authors":"Siyin Wu, Jieqiong Lou, Houdong Zou, Wei Wang, Yunyun Zhang, Yunhua Xu, Xumin Hou, Jingxiang Wu","doi":"10.2147/JPR.S529193","DOIUrl":"10.2147/JPR.S529193","url":null,"abstract":"<p><strong>Background: </strong>Day thoracic surgery requires effective analgesia and a rapid recovery. This study evaluated whether Transcutaneous Electrical Acupoint Stimulation (TEAS) reduces postoperative pain and analgesic use in lung cancer surgery.</p><p><strong>Methods: </strong>In this randomized, sham-controlled trial at a tertiary hospital in Shanghai, 100 patients (18-70 years old, ASA I-II) who underwent day lung cancer surgery (video-assisted thoracoscopic pulmonary wedge resection) were enrolled. Participants were randomized to receive either TEAS or sham TEAS in the Post-Anesthesia Care Unit. The TEAS group received 30 minutes of stimulation at Hegu (LI4) and Neiguan (PC6), whereas the sham group received electrode placement without stimulation. Primary outcome was pain intensity 24 h after surgery, measured using the visual analog scale (VAS). Secondary outcomes were VAS scores at 1 h and 12 h post-surgery, analgesic consumption, incidence of moderate-to-severe pain (VAS score >4), incidence of postoperative nausea and vomiting (PONV), Quality of Recovery (QoR-15) scores, and safety events.</p><p><strong>Results: </strong>The TEAS group had significantly lower VAS scores at 1 hour (0.94 vs 1.84, p = 0.006), 12 hours (2.00 vs 5.40, p < 0.001), and 24 hours (1.72 vs 4.02, p < 0.001). The incidence of moderate-to-severe pain within 12 hours was reduced (12.0% vs 74.0%, p < 0.001). Analgesic consumption was lower in the TEAS group. The QoR-15 scores at 24 h were higher in the TEAS group (130.8 vs 115.9, p < 0.001). No significant differences were observed in PONV, length of hospital stay, or adverse events.</p><p><strong>Conclusion: </strong>TEAS reduces postoperative pain and analgesic use, improves the recovery quality in lung cancer surgery, and supports its integration into ERAS protocols.</p><p><strong>Trial registration: </strong>ChiCTR2200066600. https://www.chictr.org.cn/showproj.html?proj=187035.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3017-3026"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-Term Functional Recovery After ACDF and ACCF in the Treatment of Adjacent Two-Level Cervical Spondylosis: A Comparative Study.","authors":"Xinyang Wang, Dingan Huang, Jianbang Han, Junjie Luo, Yingfeng Wang","doi":"10.2147/JPR.S515112","DOIUrl":"10.2147/JPR.S515112","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to comparatively analyze the mid-term functional recovery following anterior cervical discectomy and fusion (ACDF) versus anterior cervical corpectomy and fusion (ACCF) in the treatment of adjacent two-level cervical spondylosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical records of 123 patients with adjacent two-level cervical spondylosis treated at our hospital between January 1, 2018, and June 30, 2022. The patients were divided into the ACCF group (n=63) and the ACDF group (n=60) according to the surgical method. The clinical outcomes, surgical details, mid-term functional recovery, cervical Cobb angle (C2-7), overall cervical range of motion (ROM) (C2-7), adjacent segment ROM (upper and lower adjacent segments), and incidence of complications were compared between the two groups before surgery and at the final follow-up.</p><p><strong>Results: </strong>Preoperatively, there were no significant differences between the groups in JOA, VAS, and NDI scores (P > 0.05). The ACDF group had shorter operative time, less intraoperative blood loss, and lower postoperative drainage volume compared to the ACCF group (P < 0.05). The incidence of postoperative complications was also lower in the ACDF group (P < 0.05). At 18 months postoperatively, both groups showed significant improvement compared to their preoperative status (P < 0.05), with no significant differences in the rate of excellent and good outcomes between the two groups (P > 0.05). There were no significant differences between the groups in terms of cervical Cobb angle, overall cervical ROM, or ROM of the upper and lower adjacent segments (P > 0.05). Additionally, there was no significant difference in the incidence of adjacent segment degeneration between the two groups (P > 0.05).</p><p><strong>Conclusion: </strong>Both ACDF and ACCF are effective surgical options for patients with adjacent two-level cervical spondylosis, improving cervical function and alleviating pain. However, both procedures are associated with a certain incidence of complications and a reduction in cervical mobility postoperatively. Comparatively, ACDF offers advantages in terms of shorter operative time, less intraoperative blood loss, and lower postoperative drainage volume.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3009-3016"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Temporal Dynamics of Genicular Nerve Block in Primary and Secondary Knee Osteoarthritis for Pain and Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Ziqing Li, Yang Bai, Cheng Liu, Yanglin Gu","doi":"10.2147/JPR.S518315","DOIUrl":"10.2147/JPR.S518315","url":null,"abstract":"<p><strong>Purpose: </strong>Genicular nerve block (GNB) has emerged as a promising intervention for knee osteoarthritis (KOA), yet its comparative efficacy remains incompletely understood. The purpose of this review was to assess the effectiveness of GNB in reducing pain and improving function for primary or secondary KOA.</p><p><strong>Methods: </strong>We conducted systematic searches of PubMed, Web of Science, and Embase up to October 9, 2024, for randomized controlled trials comparing GNB with other therapies. The data were analyzed using Review Manager (RevMan) 5.4, and study quality was assessed using the Cochrane risk of bias tool.</p><p><strong>Results: </strong>This study included six RCTs involving a total of 420 participants. Results revealed that GNB significantly reduced pain (SMD = 1.00, 95% CI: 0.48-1.52, p=0.0002) and improved function (SMD = 1.07, 95% CI: 0.37-1.77, p=0.003) compared to other interventions. Subgroup analyses showed that GNB provided better pain relief at 2 weeks (SMD=1.21; 95% CI: 0.09-2.33; P=0.03) and greater functional improvement at 12 weeks (SMD=1.13; 95% CI: 0.10-2.16; P=0.03).</p><p><strong>Conclusion: </strong>This review suggested GNB as an effective intervention for KOA management, with distinct temporal patterns for pain relief and functional improvement.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3037-3048"},"PeriodicalIF":2.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the Effectiveness of Different Physical Therapy Modalities in the Treatment of Delayed-Onset Muscle Soreness: A Systematic Review and Bayesian Network Meta-Analysis.","authors":"Jing Chen, Qing Hu, Jiajie Hu, Songtao Liu, Linyu Yin","doi":"10.2147/JPR.S519242","DOIUrl":"10.2147/JPR.S519242","url":null,"abstract":"<p><strong>Purpose: </strong>Delayed-onset muscle soreness (DOMS) is a common clinical condition that frequently affects various populations. Physical therapy offers distinct advantages in managing this condition. However, many recently published studies have produced conflicting results and lack compelling evidence, complicating clinicians' decision making. We employed a Bayesian meta-analysis to assess the efficacy and safety of physical therapy modalities (PTMs) for DOMS, aiming to provide robust, evidence-based medical insights for clinical application.</p><p><strong>Patients and methods: </strong>We conducted a comprehensive search for randomized controlled trials (RCTs) evaluating PTMs for DOMS across databases, including CNKI, CSCD, CCD, CBM, PubMed, EMbase, Cochrane Library, and Web of Science, until October 22, 2024. The included studies were assessed for risk of bias using the Cochrane Risk of Bias Assessment tool, tailored for RCTs. A network meta-analysis was performed using R v.4.2.2.</p><p><strong>Results: </strong>At 24 hours post-intervention, photobiomodulation therapy(PBMT) demonstrated a significant advantage over placebo (-3.91 [-5.57, -2.17],P<0.05). The effects of other therapies were not significant (Cryotherapy: -0.58 (-1.20, 0.11), Cryotherapy combined with PBMT: 0.48 (-1.09, 2.01), ES: -0.98 (-2.82, 0.89), Irradiated: -0.10 (-1.71, 1.53), STM: -0.89 (-2.63, 0.85), UT: -0.61 (-1.92, 0.84)).At 48 hours post-intervention, both PBMT (-5.24 [-6.95, -3.20],P<0.05) and sauna (-3.29 [-6.21,-0.33],P<0.05) exhibited significant effects compared to placebo.The effects of other therapies were not statistically significant.; However, beyond 48 hours, there was no notable benefit from PTMs when compared with placebo, indicating that PTMs are more effective within the initial 48 hours, with PBMT yielding superior outcomes.</p><p><strong>Conclusion: </strong>The findings from this investigation indicate that PBMT and sauna treatment produce significant effects within the first 48 hours; however, beyond this period, the impact of photobiomodulation diminishes significantly. Overall, physical therapy modalities are the most effective within the 48-h window.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2993-3008"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Perceptions on Opioid Therapy for Acute Pain Management in the Emergency Department and Post-Surgical Settings: A Qualitative Study.","authors":"Evan Lucey, Erica Dean, Brittany P Chapman, Richard Perugini, Peter Chai, Charlotte E Goldfine, Stephanie Carreiro","doi":"10.2147/JPR.S518088","DOIUrl":"10.2147/JPR.S518088","url":null,"abstract":"<p><strong>Purpose: </strong>Opioids are highly effective in treating acute pain but have various detrimental, non-therapeutic effects that may lead to the development of opioid use disorder (OUD) in certain individuals. This creates a complex landscape of opioid prescribing and use. The present manuscript uses a qualitative research lens to understand the patient experience during opioid therapy for acute pain, including perceptions, behaviors, and factors that drive both during the third wave of the opioid epidemic.</p><p><strong>Patients and methods: </strong>Patients receiving opioids for acute pain were recruited from the emergency department and general surgery clinic as part of a larger study to perform continuous physiologic monitoring during opioid use. Semi-structured interviews were conducted within 10 days of hospital discharge. Interviews were recorded, transcribed verbatim and subject to applied thematic analysis by two independent coders.</p><p><strong>Results: </strong>Of the 60 subjects that completed the parent study, 44 completed the semi-structured interviews (mean age 47 years, 50% female). Three main themes emerged from the interviews: the direct effects of opioid analgesia, internal factors and external factors that influenced therapy. Symptoms of opioid tolerance, withdrawal and dependence were described in a subset of participants, even with a relatively short duration of therapy. Participants expressed a desire for more education around opioid therapy, and more engagement with their plan of care.</p><p><strong>Conclusion: </strong>Opioid therapy, even in short courses for acute pain, can be a complicated experience for patients to navigate. Prescribers should consider how patients' unique experiences and perspectives shape their responses when providing counseling to patients and monitoring of response to opioid therapy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2961-2972"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided the Prevertebral Fascia Incise and the C5 Root Hydrodissection for the Treatment of Neurogenic Thoracic Outlet Syndrome: an Application Study.","authors":"Zhenlan Liao, Yajing Zhou, Wen Cao","doi":"10.2147/JPR.S524917","DOIUrl":"10.2147/JPR.S524917","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this retrospective study was to evaluate the effectiveness of ultrasound-guided hydrodissection of the C5 nerve root, in combination with prevertebral fascia incision, as a treatment for neurogenic thoracic outlet syndrome (NTOS).</p><p><strong>Methods: </strong>Between January 2023 and January 2024, a total of 34 patients diagnosed with NTOS were enrolled in the treatment group, all of whom underwent ultrasound-guided hydrodissection of the C5 nerve root and prevertebral fascia incision. A control group consisting of 34 healthy participants was also included for comparative purposes. Preoperative and postoperative ultrasound measurements were taken at 1 and 6 weeks, including the thickness of the prevertebral fascia, the distance between the C5 nerve root and fascia, and the cross-sectional area (CSA) of the C5 nerve root. Pain intensity and functional status were assessed using the Visual Analog Scale (VAS) and Disabilities of the Arm, Shoulder, and Hand (DASH) scores.</p><p><strong>Results: </strong>Preoperative measurements in the NTOS group showed increased prevertebral fascia thickness (median: 0.1 mm [IQR 0.08-0.12]), reduced distance between the C5 nerve root and the fascia (median: 0.13 mm [IQR 0.10-0.16]), and a larger CSA of the C5 nerve root (median: 0.08 mm² [IQR 0.06-0.10]). Post-treatment, VAS scores significantly improved from a median of 7 (IQR 6-8) to 2 (IQR 2-3) at 1 week and remained stable at 6 weeks, while DASH scores improved from 85 (IQR 82-89) to 34 (IQR 31-36) at 1 week and 33 at 6 weeks.</p><p><strong>Conclusion: </strong>Ultrasound-guided hydrodissection of the C5 nerve root, along with prevertebral fascia incision, is an effective, minimally invasive treatment for NTOS.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2973-2982"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Dosage of Ciprofol for the Induction of General Anesthesia Across Diverse Age Groups in Adults: A Single-Center, Prospective, Non-Randomized Sequential Trial.","authors":"Lizhen Deng, Chunyuan Zhang, Meiyun Tan, Wei Zeng, Guozhan Luo, Ping Li","doi":"10.2147/JPR.S496223","DOIUrl":"10.2147/JPR.S496223","url":null,"abstract":"<p><strong>Purpose: </strong>A new Chinese-developed intravenous anesthetic called ciprofol enhances propofol's effectiveness against GABAA receptors by adding cyclopropyl. This study aims to determine the optimal dosage of ciprofol for inducing general anesthesia in adult patients of different ages and its correlation with Narcotrend index (NTI).</p><p><strong>Patients and methods: </strong>105 patients were stratified into three age groups: 18-40 (Group A), 41-65 (Group B), and 66-85 (Group C) years. Initial doses of 0.4 mg/kg (Groups A and B) and 0.3 mg/kg (Group C) ciprofol tosilate were administered, adjusted by 0.05 mg/kg based on sedation efficacy. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale and Dixon up-and-down method were used to calculate ED50, ED95, and NTI50.</p><p><strong>Results: </strong>Effective dosages were: youth (ED50=0.526 mg/kg, ED95=0.610 mg/kg), middle-aged (ED50=0.366 mg/kg, ED95=0.450 mg/kg), and elderly (ED50=0.324 mg/kg, ED95=0.408 mg/kg). NTI50 were 38.068 (33.496-44.188), 44.963 (39.311-52.270), and 47.214 (39.792-57.420) for the three groups, respectively.</p><p><strong>Conclusion: </strong>Ciprofol is safe and effective for anesthesia induction across age groups, with lower doses required for elderly patients. NTI reduction was dose-dependent and slower in elderly patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2983-2992"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.","authors":"Darren K Cheng, Robert Simpson, Rahim Moineddin, Joel Katz, Benoit H Mulsant, Akshya Vasudev, Michelle Greiver, Fardous Hosseiny, Marco Inzitari, Ronnie I Newman, Leon Rivlin, Kirk D Foat, Andrea D Furlan, John Francis Flannery, Deanna Telner, Rachael Bosma, Michelle Naimer, Chadwick Chung, Andrew D Pinto, Michelle L A Nelson, Ross Upshur, Abhimanyu Sud","doi":"10.2147/JPR.S515229","DOIUrl":"10.2147/JPR.S515229","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness of the virtually-delivered Sahaj Samadhi Meditation (SSM) program in reducing depressive symptoms in people with CP and moderate depressive symptoms.</p><p><strong>Methods: </strong>We conducted a randomized controlled trial comparing SSM to the Health Enhancement Program (HEP), an active control. Participants were recruited from multiple sites in the Greater Toronto Area and virtually. Both 12-week programs were delivered virtually in groups by appropriately trained facilitators. Depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9) at baseline, 12 weeks, and 24 weeks. ClinicalTrials.gov registration number: NCT04039568.</p><p><strong>Results: </strong>Of 108 participants enrolled, 89 were randomized to SSM (n=43) or HEP (n=46). Between-group differences for the PHQ-9 were not significant. Within-group mean differences for SSM were significant and greater than the minimal clinically important difference at both 12 weeks and 24 weeks (-3.97 (95% CI -6.69 to -1.24) and -4.96 (-8.36 to -1.56), respectively), while within-group mean differences were not significant for HEP.</p><p><strong>Conclusion: </strong>This study suggests potential benefits of SSM for individuals with comorbid CP and depression. Future trials should include larger sample sizes in non-pandemic conditions to better evaluate the effectiveness of SSM. Further research should also explore pragmatic trial designs and the integration of mind-body interventions in clinical settings.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2925-2946"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Locoregional Vs General Anesthesia on Incidence of Delayed Neurocognitive Recovery in Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial.","authors":"Shuqi Xie, Xi Zhao, Zitong Zhao, Min Gui, Xiaodan Cao, Xiyuan Shen, Junjie Luo, Xiaorui Chen, Yuxuan Xia, Bin Yu","doi":"10.2147/JPR.S523812","DOIUrl":"10.2147/JPR.S523812","url":null,"abstract":"<p><strong>Purpose: </strong>Delayed neurocognitive recovery is common in elderly patients undergoing major surgery under general anesthesia. We conducted a randomized controlled trial to examine whether continuous femoral nerve block plus sacral plexus block reduces the rate of delayed neurocognitive recovery in patients undergoing hip surgery.</p><p><strong>Methods: </strong>This is a single-centre, randomized controlled trial. Patients undergoing hip surgery were randomized (1:1 ratio) to undergo surgery under either continuous femoral nerve block plus sacral plexus block or general anesthesia. The primary end point was delayed neurocognitive recovery, as assessed using a battery of neuropsychological tests at 7 days after the surgery (<i>Z</i> score ≤-1.96 in at least 2 tests, and/or combined <i>Z</i> score ≤-1.96), in a modified intent-to-treat population. Secondary end points included postoperative complications, moderate/severe postoperative pain (visual analogue scale ≥4), use of opioids within 48 hours, and 6-month all-cause mortality.</p><p><strong>Results: </strong>A total of 168 patients were enrolled from January 2018 to May 2021. One hundred and sixty were included in the analysis (81 and 79 in the nerve block and general anesthesia, respectively). The rate of delayed neurocognitive recovery was 7.4% (6/81) in the continuous femoral nerve block plus sacral plexus block group versus 21.5% (17/79) in the general anesthesia group (odds ratio: 0.34, 95% CI: 0.14-0.83; P = 0.01). The rate of postoperative pulmonary infection was 1.2% (1/81) in the nerve block group versus 10.1% (8/79) in the general anesthesia group OR 0.12 (95% CI 0.02,0.95; P = 0. 02). No patient died within 6 months after surgery.</p><p><strong>Conclusion: </strong>When compared with general anesthesia, continuous nerve block anesthesia might decrease the incidence of delayed neurocognitive recover in patients undergoing hip fracture surgery. The locoregional anesthesia technique for patients undergoing hip surgery offers a safer alternative that lowers the risk of complications.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2947-2960"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fu's Subcutaneous Needling Combined with Kinematic Acupuncture versus Electroacupuncture in the Treatment of Cervical Spondylotic Radiculopathy: A Randomized Controlled Trial [Letter].","authors":"Xiaofeng Pan, Qiang Liu","doi":"10.2147/JPR.S541139","DOIUrl":"10.2147/JPR.S541139","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2923-2924"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}