Journal of Pain Research最新文献

{"title":"Evolution of the Quality of Life of Long-Term Fibromyalgia Users of Millimeter Wave-Based Neuromodulation: A Real-World Retrospective Study.","authors":"Laure Minier, Paolo Zanini, Emilie Chipon, Raphaël Gonon-Demoulian, Erwan Treillet, David Crouzier","doi":"10.2147/JPR.S498935","DOIUrl":"https://doi.org/10.2147/JPR.S498935","url":null,"abstract":"<p><strong>Purpose: </strong>Fibromyalgia (FM) is a widespread pain condition, associated with other symptoms such as fatigue, sleep disorders, stiffness, and mood disturbances. It significantly impacts patients' quality of life (QoL) and poses a substantial challenge due to the lack of a definitive cure. This study aimed to report real-world data on the long-term use (18 months) of a millimeter (MMW)-based neuromodulation device and tracking application, and its effects on various health dimensions in a self-declared FM population.</p><p><strong>Methods: </strong>This retrospective study was based on data including daily MMW wristband use and health parameters assessed at baseline (D0) and tracked weekly (pain, stiffness and fatigue) or quarterly (QoL, quality of sleep and impression of change). The primary inclusion criteria were a self-reported diagnosis of FM and consistent device usage for a minimum of 18 months.</p><p><strong>Results: </strong>The inclusion criteria were met by 185 users. There was a reduction in the Fibromyalgia Impact Questionnaire (FIQ) scores, with an average reduction of 27% after the first three months (M3), indicating improved QoL, and stabilization thereafter. Similar improvements were observed in sleep quality, stiffness and fatigue. In contrast, pain intensity showed a continuous decline throughout the 18-month period.</p><p><strong>Conclusion: </strong>The significant improvements in QoL, pain intensity, and sleep quality, maintained over time, underline the MMW device's ability to provide sustained relief and enhance daily lives of people with FM.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1143-1157"},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention Deficits in Migraine: Mismatch Negativity and P3a in an Event-Related Potential Study.","authors":"Ping Nie, Teng Wang, Qian Wu, Weikai Chen, Feifei Shen, Lin Huang, Xin Dong","doi":"10.2147/JPR.S506708","DOIUrl":"https://doi.org/10.2147/JPR.S506708","url":null,"abstract":"<p><strong>Purpose: </strong>Attention performance in chronic migraine remains unclear. The present study aimed to explore the pre-attentive detection and attention orienting ability in individuals with chronic migraine (CM) measured by mismatch negativity (MMN) and P3a components and assess their associations with migraine characteristics.</p><p><strong>Methods: </strong>This cross-sectional observational study recruited 25 individuals with episodic migraine (EM), 25 individuals with CM and 25 healthy controls (HC) matched for age, sex, and educational level. The MMN and P3a components were measured using event-related potential (ERPs) tools with auditory oddball paradigms and migraine characteristics were collected.</p><p><strong>Results: </strong>Individuals with CM exhibited a longer MMN latency (p = 0.010) and a lower P3a amplitude than HC (p = 0.004) and EM (p = 0.002). Correlation analysis showed that P3a amplitude was negatively correlated with headache attack frequency and the Migraine Disability Assessment Scale (MIDAS), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD) scores.</p><p><strong>Conclusion: </strong>Individuals with CM showed deficits in pre-attentive detection and attention orientation. Moreover, attention-oriented dysfunction is associated with headache attack frequency, headache-related disability, anxiety and depression.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1161-1171"},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Electromagnetic Field Therapy in Mechanical Low Back Pain: A Randomized Controlled Trial.","authors":"Ghada Mohamed Rashad Koura, Ahmed Mohamed Fathi Elshiwi, Mastour Saeed Alshahrani, Doaa Ayoub Elimy, Razan Abdurahman Nasser Alshahrani, Fareed F Alfaya, Shaker Hassan S Alshehri, Amal A Hadi, Mohammed Abdullah Alshehri, Hani Hassan Alnakhli, Fuzail Ahmad, Irshad Ahmad","doi":"10.2147/JPR.S500698","DOIUrl":"10.2147/JPR.S500698","url":null,"abstract":"<p><strong>Background: </strong>Between half and three quarters of the working-age population in today's industrialized globe suffers from lower back pain. The presence of a myofascial trigger point-a hyperirritable painful area comprised of a small number of muscle fibers-identifies mechanical back pain sufferers as suffering from myofascial pain syndrome, a chronic pain disorder. This research objectives to determine whether mechanical back pain patients' pain severity and functional disabilities are influenced by electromagnetic field therapy.</p><p><strong>Methods and subjects: </strong>Two groups of thirty patients were randomly assigned. The 15 participants in group A underwent conventional physical therapy (including ultrasound, stretches, and strength training for the back muscles), while the 15 participants in group B received a combination of conventional physical therapy and electromagnetic field therapy. Pre- and post-treatment assessments of pain intensity, functional impairment, and lumbar range of motion (including extension, flexion, and right and left side bending) were examined. The variables of interest that were examined at various testing groups and measuring periods were compared using a 2×2 mixed design MANOVA.</p><p><strong>Results: </strong>After treatment, there was a significant difference in all dependent variables between the two groups in terms of between-subject effects (p <0.05). Group B benefited from a significant decrease in pain, right and left side bending, and function disability, as well as an increase in flexion and extension.</p><p><strong>Conclusion: </strong>Patients suffering from mechanical back pain can find relief from their discomfort and functional impairment through the use of electromagnetic field therapy, according to the current study's conclusions.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1131-1142"},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Acupuncture on Myofascial Trigger Points Versus Traditional Chinese Medicine Acupoints for Treating Plantar Fasciitis With Low Back Pain: A Study Protocol for a Randomised Clinical Trial [Letter].","authors":"Jia Wang, Wenxia Qi, Jiexiang Tian","doi":"10.2147/JPR.S523212","DOIUrl":"10.2147/JPR.S523212","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1109-1110"},"PeriodicalIF":2.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats.","authors":"Wenyun Kui, Yanan Li, Zhen Gu, Lei Xie, Aiping Huang, Shuyi Kong, Lilong Song, Lingxing Li, Jun Yu, Chun-Chun Xue, Kaiqiang Wang","doi":"10.2147/JPR.S506569","DOIUrl":"10.2147/JPR.S506569","url":null,"abstract":"<p><strong>Background: </strong>Patients with neuropathic pain (NP), caused by injury or disease of the somatosensory nervous system, usually suffer from severe pain. Our previous studies revealed that electroacupuncture (EA) stimulation could effectively improve NP. However, the underlying mechanisms of EA have not been fully clarified. This study aimed to investigate the specific mechanisms of EA in alleviating NP, focusing on the pyroptosis.</p><p><strong>Materials and methods: </strong>Chronic Constriction Injury (CCI) model was established on the male Sprague-Dawley rats. CCI rats were treated with EA at acupoints GV20 and ST36 or/with the NOD-like receptor protein 3 (NLRP3) antagonist MCC950. EA treatment was administered for successive 14 days 7 days after the CCI surgery. The mechanical withdrawal threshold (MWT) and paw withdrawal latency (PWL) were performed during the experiment. At the end of the experiment, spinal cord segments and serum of rats were collected, ELISA detected the expression of inflammatory factors, immunofluorescence detected the microglia and neuron cells with pyroptosis biomarkers, and Western blot detected the NLRP3 pathway.</p><p><strong>Results: </strong>EA treatment significantly alleviated pain hypersensitivity by increasing the MWT and PWL. Moreover, EA reduced levels of pro-inflammatory cytokines IL-1β and TNF-α in the spinal tissue. Mechanistically, the pyroptosis-related proteins, including NLRP3, N-GSDMD, Cleaved Caspase-1, IL-18 as well as IL-1β were downregulated by EA, indicating that EA attenuated the pyroptosis phenotype in NP rats. In particular, EA reduced the co-expression of NLRP3, Caspase-1 and N-GSDMD in microglia rather than in neuronal or astrocytic cells within the spinal cord of CCI rats. Pharmacological inhibition of NLRP3 inflammasome by MCC950 alleviates CCI-induced pain hypersensitivity while blocking EA's effect on anti-pyroptosis in CCI rats.</p><p><strong>Conclusion: </strong>These findings demonstrate the EA ameliorates the neuroinflammation and pyroptosis to relieve chronic NP by suppressing NLRP3 inflammasome activation in microglia. EA may serve as a viable treatment therapy for chronic NP.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1115-1129"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Acupuncture on Myofascial Trigger Points versus Traditional Chinese Medicine Acupoints for Treating Plantar Fasciitis with Low Back Pain: A Study Protocol for a Randomised Clinical Trial [Letter].","authors":"Swarup Ghosh, Sanam Maurya, Sandeep Pattnaik","doi":"10.2147/JPR.S523473","DOIUrl":"10.2147/JPR.S523473","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1111-1113"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of Risk Score for Serious Non-Steroidal Anti-Inflammatory Drug (NSAID) Induced Cardiovascular Events (NAÏVE) Among Active-Duty Service Members and Veterans.","authors":"Timothy J Atkinson, Justin Petway, Whitney L Forbes, Hannah Thorfinnson, Ryan C Costantino, Laura E Gressler","doi":"10.2147/JPR.S503743","DOIUrl":"10.2147/JPR.S503743","url":null,"abstract":"<p><strong>Importance: </strong>This study addresses the critical need for an evidence-based instrument to assess the likelihood of NSAID-induced cardiovascular events, that provides clinicians with valuable decision support to improve safety in their use for pain management, especially in patients vulnerable to cardiovascular events.</p><p><strong>Objective: </strong>To develop a practical risk scoring tool, NSAID Induced Cardiovascular Events (NAÏVE), for estimating the risk of serious cardiovascular events associated with NSAID use.</p><p><strong>Design: </strong>Retrospective nested case-control study.</p><p><strong>Setting: </strong>The study leveraged data from the DAVINCI database, integrating electronic health records, administrative data, and clinical data from both the Veterans Health Administration (VHA) and the Department of Defense (DoD).</p><p><strong>Participants: </strong>The study cohort consisted of individuals with at least one NSAID pharmacy claim, with cases defined as those experiencing non-fatal myocardial infarction, non-fatal stroke, or new heart failure.</p><p><strong>Interventions: </strong>Development of the NAÏVE risk scoring tool involved a comprehensive analysis of demographic, clinical, and prescription-related variables, including NSAID exposure, comorbidities, and medication history.</p><p><strong>Main outcomes/measures: </strong>The primary outcome was the first occurrence of a cardiovascular event.</p><p><strong>Results: </strong>The study cohort comprised 231,967 cases and 2,319,670 controls, identified from individuals with at least one NSAID pharmacy claim between October 1, 2016, and September 30, 2020. The risk index, NAÏVE, demonstrated strong discriminatory ability and calibration, with a C-statistic of 0.88. Variables such as age, NSAID exposure, comorbidities, and medication history were associated with increased odds of NSAID-induced cardiovascular events.</p><p><strong>Conclusions/relevance: </strong>NAÏVE is the first evidence-based risk scoring tool providing clinicians with valuable decision support for assessing the potential risk of serious cardiovascular events associated with NSAID use. It fills a crucial gap in clinical practice, allowing for transparent discussions with patients and shared decision-making regarding NSAID prescriptions. Further validation and prospective testing are warranted for broader applicability.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1081-1094"},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Activation and Functional Connectivity Response to Different Interactive Modes of Virtual Reality (VR)-Induced Analgesia: A Prospective Functional Near-Infrared Spectroscopy (fNIRS) Study.","authors":"Xue Deng, Naifu Jiang, Zhaoying Huang, Qi Wang","doi":"10.2147/JPR.S492361","DOIUrl":"10.2147/JPR.S492361","url":null,"abstract":"<p><strong>Aim: </strong>Virtual reality (VR) can be analgesic through intercortical modulation. This study investigated neural activities and correlates during different interactive modes.</p><p><strong>Methods: </strong>Fifteen healthy participants (4M, 11F, age 21.93 ± 0.59 years) underwent functional near-infrared spectroscopy (fNIRS) to compare cortical activation and functional connectivity (FC) across brain regions of interest (ROI) and channels (CH) during VR experiences. In the active mode (AM), participants engaged with the virtual environment through motor actions. In the passive mode (PM), participants stood still with their eyes closed, listening to the virtual environment's music.</p><p><strong>Results: </strong>A better analgesic effect was observed in the AM (t = 3.572, p = 0.001) with higher visual-sensorimotor cortical activation (t = 2.59 to 3.99, p = <0.001 to 0.015, p-FDR < 0.05). AM showed significant correlations between ratings (pain level and immersion) of VR questionnaire and visual-motor ROIs (r = 0.547 to 0.595, p = 0.013 to 0.038). PM only correlated with pain level and CH 37 (r = 0.608, p = 0.016). FC between S1 and visual-motor-auditory regions was lower in the AM (t = -4.64 to -3.53, p = 0.029 to 0.049).</p><p><strong>Conclusion: </strong>VR-induced analgesia occurs via augmenting the visual-sensorimotor-auditory cortical activation, reducing S1 connectivity and weakening pain processing.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1095-1108"},"PeriodicalIF":2.5,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Unilateral Biportal Endoscopy Compared With Transforaminal Route Percutaneous Endoscopic Lumbar Decompression in the Treatment of Lumbar Spinal stenosis: Minimum 1-year Follow-up.","authors":"Weixiang Sun, Jie Wang, Yafei Hu, Jinzhuo Tao, Chengwu Yang","doi":"10.2147/JPR.S493602","DOIUrl":"10.2147/JPR.S493602","url":null,"abstract":"<p><strong>Objective: </strong>This study compared the efficacy and safety of unilateral biportal endoscopic (UBE) decompression and transforaminal route percutaneous endoscopic lumbar decompression (PELD) for lumbar spinal stenosis (LSS), assessing 1-year clinical outcomes.</p><p><strong>Methods: </strong>A total of 120 patients (64 UBE, 56 PELD) diagnosed with LSS in 2021 were evaluated. Perioperative outcomes included overall operation time, extracanal operative time, intracanal decompression time, incision length, fluoroscopy time, estimated blood loss, preoperative and postoperative day 3 hb levels, length of post-operative hospital stays, total expenses, postoperative complications. Clinical outcomes were measured using visual analog scale (VAS) for back and leg pain, Oswestry disability index (ODI) for physical impairment and the modified MacNab criteria.</p><p><strong>Results: </strong>Results showed no demographic differences between groups. UBE had shorter total operation and intracanal decompression times but longer extracanal operative time than PELD (all <i>P</i><0.01). Fluoroscopy time was significantly lower in UBE (<i>P</i><0.01). While UBE had longer incisions, greater blood loss, and higher costs, hemoglobin level changes and hospital stays were similar between groups. Postoperatively, UBE resulted in lower VAS-leg pain scores (<i>P</i><0.01) and had a higher excellent/good rate (93.75% vs 85.71%, <i>P</i><0.05). Moreover, there were 3 patients in PELD group who needed a revision surgery at the same level within postoperative 1-year follow-up due to the unrelieved symptoms.</p><p><strong>Conclusion: </strong>Both techniques were safe, but PELD posed a higher risk of reoperation due to decompression failure. UBE demonstrated advantages in decompression efficiency and clinical outcomes despite longer incision length and greater blood loss.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1071-1080"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid Differentiation Primary Response Protein 88: An Important Therapeutic Target for Chronic Pain.","authors":"Hanlin Liang, Linbin Fu, Zheng Li, Zhiheng Liu","doi":"10.2147/JPR.S487685","DOIUrl":"10.2147/JPR.S487685","url":null,"abstract":"<p><p>Chronic pain is a major cause of suffering. This interferes with daily functioning and is often accompanied by distress. However, current therapeutic strategies for chronic pain are unsatisfactory because of poor understanding of its mechanisms. Therefore, more comprehensive therapeutic targets must be identified to improve the quality of life of these patients. Myeloid differentiation primary response protein 88 (MyD88) is an adaptor protein of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) families. Recently, overexpression of MyD88 in the spinal and dorsal root ganglia was observed in multiple pain models, which also revealed that MyD88 plays an important role in the development and maintenance of chronic pain. In this review, we summarized the roles and mechanisms of MyD88 in the progression of different pain models, including chemotherapy-induced peripheral neuropathy (CIPN), diabetic neuropathic pain (DNP), spinal nerve ligation (SNL), chronic constriction injury (CCI), spinal cord injury (SCI) and inflammatory pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1061-1069"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}