Yifan Lu, Chengyin Lu, Gonghui Jian, Hui Xiong, Yang Shu
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Mechanistic Study on the Therapeutic Effects of Juanbi Lijieqing Formula in a Rat Model of Gouty Arthritis with Hyperuricemia.
Background: This study evaluated the therapeutic effects and underlying mechanisms of Juanbi Lijieqing Formula (JBLJQF) in a rat model of gouty arthritis with hyperuricemia.
Methods: Forty-two rats were randomly assigned to seven groups: control, model, etoricoxib, benzbromarone, and low-, medium-, and high-dose JBLJQF. General condition, joint swelling, behavioral performance, biochemical markers, and histopathology were assessed. Urate Anion Transporter 1(URAT1) expression was examined via immunofluorescence and Western blot.
Results: JBLJQF improved general condition, reduced joint swelling, and alleviated kidney damage. Medium- and high-dose groups showed enhanced pain threshold and locomotor activity. Serum uric acid, TNF-α, and IL-1β levels were significantly decreased. URAT1 expression was downregulated, suggesting reduced renal urate reabsorption.
Conclusion: JBLJQF exerts anti-inflammatory, uric acid-lowering, and organ-protective effects in gouty arthritis with hyperuricemia, highlighting its potential for clinical application.
期刊介绍：
Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.
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