Journal of oral biology and craniofacial research最新文献

{"title":"Root-level vulnerability and lingual plate fracture risk in mandibular third molars: A retrospective CBCT-based cross-sectional study","authors":"Son Hoang Le ,&nbsp;Bich-Ly Thi Nguyen","doi":"10.1016/j.jobcr.2026.101461","DOIUrl":"10.1016/j.jobcr.2026.101461","url":null,"abstract":"<div><h3>Background</h3><div>Prior studies investigating the relationship between lingual plate (LP) fracture risk and mandibular third molar (M3M) anatomy have produced inconsistent findings. Factors such as age, sex, impaction depth, and buccolingual angulation have shown variable associations with fracture risk. Importantly, M3M rotational angulation has rarely been evaluated. While most research has focused on the middle and apical thirds of the root, one clinical study suggested the cemento-enamel junction may represent a structurally vulnerable site.</div></div><div><h3>Objectives</h3><div>This study aimed to identify anatomical and demographic risk factors associated with LP fracture across the coronal, middle, and apical thirds of the M3M root.</div></div><div><h3>Methods</h3><div>Cone beam computed tomography (CBCT) images of 300 mandibular third molars were retrospectively reviewed. Data collected included patient sex, age, tooth side, and spatial alignment. M3M root length was measured and divided into coronal, middle, and apical thirds. The thinnest LP region at each level was recorded, and fracture risk was classified into three categories: low, moderate, and high. Ordinal logistic regression was used to determine significant risk factors.</div></div><div><h3>Results</h3><div>Fracture risk was significantly lower in the coronal third compared to the middle and apical thirds. Younger patients exhibited higher fracture risk at all levels. Greater root length increased risk at the apical third. Horizontal impaction level II, mesial and horizontal angulations, and buccal inclination were associated with elevated risk, while lingual inclination and rotational angulation reduced risk.</div></div><div><h3>Conclusion</h3><div>Age, root morphology, impaction depth, and three-dimensional M3M angulations are key predictors of LP fracture risk at distinct root levels.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 3","pages":"Article 101461"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of cetylpyridinium chloride–modified EDTA, sequential, and continuous chelation on smear layer removal and dentin erosion","authors":"Huda Hassan Khairy,&nbsp;Alaa Jawad Kadhim","doi":"10.1016/j.jobcr.2026.101459","DOIUrl":"10.1016/j.jobcr.2026.101459","url":null,"abstract":"<div><h3>Objective(s)</h3><div>Evaluate the effectiveness of cetylpyridinium chloride (cpc) addition to EDTA (CPC-modified EDTA) compared to standard sequential (SC) and continuous (CC) chelation protocols in removing the smear layer and dentine erosion.</div></div><div><h3>Materials and methods</h3><div>The concentration of CPC was determined by pilot research based on surface tension and contact angle (0.2%). In the current study, sixty single roots-human mandibular premolars were divided into five groups (n = 12) according to irrigation protocol:sequential chelation using CPC-modified EDTA; conventional Sequential chelation using EDTA; continuous chelation using NaOCl mixed with HEDP; NaOCl alone and normal saline alone. The roots were separated longitudinally to evaluate the smear layer and dentine erosion utilizing SEM; and the obtained data were analyzed using Kruskal-Wallis and Mann-Whitney U tests.</div></div><div><h3>Results</h3><div>Similar effectiveness was observed between the sequential and continuous chelation protocols when EDTA alone was used (P &gt; 0.05), However, CPC-modified EDTA used in the sequential protocol showed significantly greater smear layer removal than continuous chelation protocol particularly in the apical third(P &lt; 0.05), while a similar effect on dentin erosion was observed among groups (P &gt; 0.05).</div></div><div><h3>Conclusion(s)</h3><div>The addition of a surfactant to the root canal irrigant showed better results; however, the difference was statistically significant only in the apical third At the apical third, CPC-modified EDTA demonstrated significantly better smear layer removal compared to the CC protocol, while showing a similar effect on dentin erosion compared to both SC and CC protocols.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 3","pages":"Article 101459"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of ozone therapy and antimicrobial photodynamic therapy in periodontitis: A randomized clinical trial","authors":"Shilpi Mangal ,&nbsp;Shalini Kaushal ,&nbsp;Nand Lal ,&nbsp;Anjani Kumar Pathak ,&nbsp;Bhaskar Agarwal ,&nbsp;Suruchi Shukla","doi":"10.1016/j.jobcr.2025.12.011","DOIUrl":"10.1016/j.jobcr.2025.12.011","url":null,"abstract":"<div><h3>Background</h3><div>This randomized clinical trial evaluated the comparative efficacy of ozone therapy and ICG-mediated antimicrobial photodynamic therapy as adjunctive to scaling and root planing in the management of periodontitis, by assessing clinical outcomes, inflammatory biomarkers, specifically interleukin-1β (IL-1β) and Pentraxin-3 (PTX-3), and microbial load via quantitative PCR.</div></div><div><h3>Methods</h3><div>This is a parallel-arm, single-blinded, randomized controlled trial that included 36 patients with Stage III Grade B periodontitis, allocated randomly to three groups. Group 1 {Scaling and Root planing (SRP)}, Group 2 {SRP + Ozone Therapy (OT}), and Group 3 {SRP + Antimicrobial Photodynamic Therapy (aPDT)}. Clinical parameters, biochemical markers, and microbial count were recorded at baseline, 1 month, and 3 months.</div></div><div><h3>Result</h3><div>The change in Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) from baseline to 1 month and from baseline to 3 months was significantly higher in the SRP + OT group (<em>p</em> &lt; 0.001). Reduction in the microbial count of <em>Porphyromonas gingivalis</em> (Keystone pathogen) (Mean difference = −0.70, <em>p</em> &lt; 0.001) and <em>Tannerella forsythia</em> (−0.51, <em>p</em> &lt; 0.001), whereas <strong>SRP + aPDT provided superior suppression</strong> for <em>Fusobacterium nucleatum</em> (−0.76, <em>p</em> &lt; 0.001) and <em>Prevotella intermedia</em> (0.40, <em>p</em> &lt; 0.001). No meaningful difference was observed between the two adjuncts for <em>Treponema denticola</em> (<em>p</em> = 0.994).</div></div><div><h3>Conclusion</h3><div>All treatment modalities resulted in significant improvements in all the parameters over time. However, SRP + Ozone Therapy consistently achieved the improvement across all parameters, when compared to SRP alone or SRP with aPDT.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101393"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145957725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of canine-guided and bilateral balanced occlusion appliances in managing TMJ disc displacement with Reduction-A randomised clinical trial","authors":"Renita Lorina Castelino ,&nbsp;Chethan Hegde ,&nbsp;Srikant Natarajan","doi":"10.1016/j.jobcr.2026.101412","DOIUrl":"10.1016/j.jobcr.2026.101412","url":null,"abstract":"<div><h3>Background</h3><div>Among the intracapsular disorders of the temporomandibular joint (TMJ), disc displacement with reduction (DDwR) occurs most frequently. Canine-guided orthotic appliances may increase loading on the contralateral TMJ during eccentric movements due to the leverage effect generated on the working side whereas bilateral balanced occlusion appliances may promote uniform force distribution, reducing contralateral joint stress in patients with DDwR. Evidence comparing the effectiveness of canine-guided and bilateral balanced occlusion orthotic appliances in the management of DDwR remains limited.</div></div><div><h3>Aim</h3><div>This study compared the effectiveness of canine-guided and bilateral balanced occlusion orthotic appliances in reducing pain, assessed using the Visual Analog Scale (VAS), in patients with DDwR.</div></div><div><h3>Material and methods</h3><div>This study included 68 patients with painful TMJ DDwR (RDC/TMD Group IIa). Participants were randomly assigned to two groups: Group 1 received a canine-guided orthotic appliance, and Group 2 received a bilateral balanced occlusion orthotic appliance. Pain intensity was assessed using the VAS at baseline, 15, 30, and 90 days.</div></div><div><h3>Results</h3><div>Mann-Whitney <em>U</em> test was used for group comparisons which demonstrated Group 2 achieved significantly lower VAS scores during early assessments, while Group 1 exhibited more notable reductions between 30 and 90 days. Wilcoxon test was used to assess improvement within groups which demonstrated significant improvement in both the groups with p value &lt; 0.001.</div></div><div><h3>Conclusions</h3><div>The bilateral balanced occlusion appliance produced faster pain reduction with lower VAS scores, particularly between 15 and 30 days. The canine-guided appliance showed greater pain reduction between 30 and 90 days. Both interventions effectively reduced pain.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101412"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of type I collagen on TLR-3 induced MMP-13 expression in human periodontal ligament fibroblasts","authors":"Ratthawut Namwad ,&nbsp;Pitchaya Chaiyaraksa ,&nbsp;Nirada Dhanesuan ,&nbsp;Siriluck Tiranathanagul","doi":"10.1016/j.jobcr.2026.101420","DOIUrl":"10.1016/j.jobcr.2026.101420","url":null,"abstract":"<div><h3>Background</h3><div>This study examined the effects of type I collagen, alone and in combination with poly I:C—a toll-like receptor 3 (TLR3) agonist—on matrix metalloproteinase-13 (MMP-13) expression and wound healing in human periodontal ligament (hPDL) fibroblasts.</div></div><div><h3>Methods</h3><div>hPDL fibroblasts were cultured and divided into four treatment groups: control, type I collagen (50 μg/mL), poly I:C (10 μg/mL), and a combination of type I collagen with poly I:C. Cytotoxicity was evaluated using the MTT assay. Cell migration was assessed via scratch assay at 0, 24, and 48 h. MMP-13 expression was quantified at both the mRNA and protein levels by real-time PCR and ELISA, respectively.</div></div><div><h3>Results</h3><div>After 24 h, the MTT assay indicated that none of the four treatment groups exhibited cytotoxicity toward hPDL fibroblasts. In the scratch assay at 24 and 48 h, type I collagen group demonstrated the fastest wound closure, whereas the poly I:C group showed the slowest migration. Regarding MMP-13 expression, the combination group displayed the highest mRNA levels, while ELISA revealed that both the combination and poly I:C groups had the greatest protein expression relative to the control.</div></div><div><h3>Conclusion</h3><div>This study provides evidence for an interaction between extracellular matrix signals and innate immune activation. Type I collagen promoted hPDL fibroblast migration, whereas poly I:C—a TLR3 agonist—upregulated MMP-13 expression, with the greatest effect observed in combination with collagen.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101420"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile and prevalence of odontogenic keratocysts in children and adolescents: A systematic review","authors":"Jéssica da Silva Cunha ,&nbsp;Raisa Severino-Lazo ,&nbsp;Joaquim Felipe Junior ,&nbsp;Allan Vinícius Martins-de-Barros ,&nbsp;Julliana Carvalho ,&nbsp;Belmiro Cavalcanti do Egito Vasconcelos ,&nbsp;Marianne Vasconcelos Carvalho","doi":"10.1016/j.jobcr.2026.101414","DOIUrl":"10.1016/j.jobcr.2026.101414","url":null,"abstract":"<div><div>Odontogenic keratocyst (OKC) exhibits aggressive behavior and a high potential for recurrence. Despite being well-documented in adults, its characteristics in the pediatric population remain poorly understood. This systematic review aimed to analyze the clinical profile and treatment modalities of OKCs in children and adolescents, as well as their association with recurrence and follow-up duration. This systematic review was conducted following PRISMA guidelines and registered in PROSPERO (CRD42024612291). Risk of bias was assessed using the ROBINS-E tool, and statistical analysis was performed with the chi-square test. A total of 34 studies published between 2014 and 2024 were included, comprising 98 pediatric cases, both sporadic and syndromic. Both groups showed a slight male predominance, with a mean age of 12 years, and the most common symptom was extraoral swelling, with or without pain. The cases showed a predominance of lesions in the posterior mandible. Conservative approaches were the most frequently adopted treatment modality. The chi-square test revealed a statistically significant association between treatment modality and recurrence (p = 0.031), as well as between recurrence and follow-up duration (p = 0.005). Despite the variety of therapeutic strategies, recurrence was more strongly associated with follow-up duration than with the treatment approach itself. Based on these findings, we strongly recommend that all pediatric patients diagnosed with OKC undergo clinical and radiographic monitoring for a minimum of five years, regardless of the treatment performed, to ensure early detection and management of late recurrences.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101414"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of remineralizing potential of galla chinensis with nanohydroxyapatite, chicken egg shell and fish scale derived nanohydroxyapatite on early enamel caries- A single-blinded In vitro study","authors":"Bazila Malik ,&nbsp;Sonali Taneja ,&nbsp;Ramesh Bharti ,&nbsp;Abhik Mukherjee","doi":"10.1016/j.jobcr.2026.101417","DOIUrl":"10.1016/j.jobcr.2026.101417","url":null,"abstract":"<div><h3>Objective(s)</h3><div>This study aimed to evaluate and compare the remineralization potential of plant-based Galla chinensis extract (GCE) with nanohydroxyapatite (nHAp), chicken eggshell-derived nHAp (CES nHAp), and fish scale-derived nHAp (FS nHAp), against casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), on early artificial enamel lesions in human premolars.</div></div><div><h3>Materials and methods</h3><div>A total of 148 human premolar specimens were prepared and demineralized to simulate early enamel caries, with five intact samples serving as baseline controls. Among these, 48 samples underwent surface microhardness testing using the Vickers hardness test, 60 were analyzed for lesion depth using Polarized Light Microscopy (PLM), 30 for elemental composition using Energy Dispersive X-ray (EDX) spectroscopy, and 10 for surface morphology using Scanning Electron Microscopy (SEM). The specimens were randomly assigned into five groups: demineralized control, CPP-ACPF, GCE with nHAp, CES nHAp, and FS nHAp. A seven-day pH cycling regimen simulated the oral environment. Microhardness values before demineralization (SMH1), after demineralization (SMH2), and after remineralization (SMH3) were recorded to calculate percentage surface microhardness recovery (%SMHR).</div></div><div><h3>Results</h3><div>The GCE nHAp group exhibited the highest %SMHR and the shallowest lesion depth, with EDX confirming a significantly higher calcium-to-phosphorus ratio. SEM images revealed smoother, more uniform surfaces in this group. CES nHAp and CPP-ACPF demonstrated moderate remineralizing effects, while FS nHAp showed the least efficacy, with no significant difference from CPP-ACPF.</div></div><div><h3>Conclusion(s)</h3><div>GCE combined with nHAp was the most effective remineralizing agent, followed by CES nHAp and CPP-ACPF. These findings suggest that natural plant- and animal-derived biomaterials offer promising, biocompatible alternatives for non-invasive enamel caries management.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101417"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OSFCOS: A core outcome set for clinical trials on oral submucous fibrosis management","authors":"Shailesh M. Gondivkar ,&nbsp;Amol R. Gadbail ,&nbsp;Monal Yuwanati ,&nbsp;Vidya Lohe ,&nbsp;Sachin Sarode","doi":"10.1016/j.jobcr.2026.101421","DOIUrl":"10.1016/j.jobcr.2026.101421","url":null,"abstract":"<div><h3>Background</h3><div>Oral Submucous Fibrosis (OSF) significantly impacts oral function, quality of life and poses challenges for effective treatment evaluation due to heterogeneity in outcome reporting across clinical trials. To date, no core outcome set (COS) exists for OSF trials, leading to significant heterogeneity in outcome reporting and difficulty in comparing interventions. This study aimed to develop a COS for OSF (OSFCOS) to standardize outcome reporting in clinical trials evaluating OSF management.</div></div><div><h3>Methods</h3><div>The study followed COMET and COS-STAD guidelines and involved four stages: a systematic review of randomized controlled trials to identify reported outcomes; qualitative research using interviews and focus groups with OSF patients to capture patient-prioritized outcomes; a two-round Delphi survey with key stakeholders (patients, clinicians, researchers); and a consensus meeting to finalize core outcomes. Outcomes were rated using a 9-point GRADE scale, and consensus was predefined using standard thresholds.</div></div><div><h3>Results</h3><div>A total of 20 outcomes were identified from systematic review and 31 from qualitative analysis. After triangulation &amp; refinement, 16 unique outcomes were prioritized in Delphi Round 1 (n = 45). Delphi Round 2 (n = 25) rated 23 outcomes; 10 reached “consensus in.” A consensus meeting with 17 stakeholders reviewed 13 outcomes and finalized 7 core outcomes for OSFCOS.</div></div><div><h3>Conclusion</h3><div>This is the first COS developed specifically for OSF that offers a robust, stakeholder-driven framework for standardized outcome reporting, comparability and enhancing data synthesis in OSF trials for better evidence generation and patient care.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101421"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan–gelatin scaffold reinforced with carbonate hydroxyapatite enhances bone healing in rat extraction sockets: An immunohistochemical study","authors":"Devi Rianti ,&nbsp;Bunga Fauzia ,&nbsp;Taufan Bramantoro ,&nbsp;Rini Devijanti Ridwan ,&nbsp;Asti Meizarini ,&nbsp;Sisca Meida Wati ,&nbsp;Wibi Riawan ,&nbsp;Ardiyansyah Syahrom ,&nbsp;Meircurius Dwi Condro Surboyo","doi":"10.1016/j.jobcr.2026.101416","DOIUrl":"10.1016/j.jobcr.2026.101416","url":null,"abstract":"<div><h3>Background</h3><div>Tooth extraction commonly leads to alveolar bone loss, which can compromise future prosthetic rehabilitation. Biomaterial-based socket preservation aims to support hard-tissue healing and stabilize the extraction site.</div></div><div><h3>Objective</h3><div>To assess the effect of a chitosan–gelatin scaffold reinforced with carbonate hydroxyapatite (CG-CHA) on bone healing in Wistar rats extraction sockets by evaluating immunohistochemical expression of Bone morpogenetic protein 2 (BMP-2), Runt-related transcription factor 2 (RUNX2) and Receptor activator of nuclear κB (RANK).</div></div><div><h3>Materials and methods</h3><div>A true-experimental randomized post-test only control group design was used with 24 male Wistar rats. Following maxillary molar extraction, rats were assigned to either a control group (extraction only) or a CG-CHA scaffold group (n = 12 each). Mandibles were collected on days 7, 14, and 21 (n = 4 per time point per group). Immunohistochemistry were performed to evaluate the expression of BMP-2, RUNX2, and RANK. Data were analyzed using independent t-tests with significance at p &lt; 0.05.</div></div><div><h3>Results</h3><div>The CG-CHA group showed greater bone formation and significantly higher BMP-2, RUNX2, and RANK expression at days 7, 14, and 21 compared to controls (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Placement of a CG-CHA scaffold in extraction sockets improved bone healing and increased osteogenic marker expression in rats. These findings indicate that CG-CHA supports favorable socket healing and may be useful for alveolar bone preservation strategies.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101416"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of contracted eye socket","authors":"Eman Mohammed Mahmoud ,&nbsp;Ahmed Ali Taha ,&nbsp;Essam A. Eltoukhy ,&nbsp;Ashraf Elsebaei Mohammed ,&nbsp;Ahmed F. Aborady","doi":"10.1016/j.jobcr.2026.101429","DOIUrl":"10.1016/j.jobcr.2026.101429","url":null,"abstract":"<div><h3>Background</h3><div>Anophthalmia—the absence of an eye—can significantly impact patients’ psychological well-being, affecting self-confidence, body image, social interactions, and contributing to anxiety and depression. Contracted socket, characterized by reduced orbital volume and forniceal depth, poses a major challenge to fitting an ocular prosthesis. This study evaluates the effectiveness of skin grafts and mucous membrane grafts in forniceal reconstruction.</div></div><div><h3>Methods</h3><div>This prospective case series included 25 patients with varying degrees of contracted sockets treated between October 2020 and December 2023. Etiologies included congenital anophthalmia, chemical burns, radiotherapy, infection, and trauma. Reconstruction was performed using mucous membrane grafts (MMG) or full-thickness skin grafts (FTSG), according to the severity of socket contraction. Outcomes were evaluated based on the ability to retain a prosthesis and patient satisfaction.</div></div><div><h3>Results</h3><div>Twenty-four of the 25 patients achieved successful prosthesis retention. Complications were minimal and appropriately managed. Serial dilatation was particularly important in preventing re-contracture, especially in Grade 4 sockets.</div></div><div><h3>Conclusions</h3><div>Simple reconstructive techniques using MMG and FTSG can restore forniceal depth effectively, achieving favorable cosmetic and functional outcomes while minimizing the need for complex procedures.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101429"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}