Journal of oral biology and craniofacial research最新文献

{"title":"Solitary fibrous tumor of temporal and infratemporal region: A case report and review of rare entity","authors":"Rajesh chauhan,&nbsp;Virendra Singh,&nbsp;Ankita dahiya,&nbsp;Jishnu mohan","doi":"10.1016/j.jobcr.2025.02.008","DOIUrl":"10.1016/j.jobcr.2025.02.008","url":null,"abstract":"<div><div>Solitary fibrous tumor (SFT) is a rare, benign spindle-cell neoplasm initially thought to be of mesothelial origin but later recognized as mesenchymal. While uncommon in the head and neck region, SFTs typically present in the oral cavity, orbit, and paranasal sinuses. The tumor's imaging characteristics, such as those seen in ultrasound and MRI, can often mimic vascular lesions, leading to diagnostic challenges. This report presents a case of a 36-year-old female with a painless, gradually enlarging mass in the left temporal region. Imaging suggested a fusiform hypoechoic lesion in the infratemporal region, likely involving the temporal bone and masticator space. Surgical excision was performed using the Alkayat-Bramley approach with zygomatic arch osteotomy for better access. Histopathology revealed spindle cells in a collagenous stroma with vascular spaces, multinucleated giant cells, and hemorrhagic areas, confirmed as SFT by positive immunohistochemical markers (Vimentin, S100, CD34, BCL2, and STAT6). Postoperative recovery was uneventful, and there was no recurrence at follow-up.</div><div>SFTs in the head and neck often present with nonspecific symptoms due to their slow growth and lack of compression of vital structures. Imaging features may suggest a vascular lesion, but definitive diagnosis requires histopathological and immunohistochemical confirmation. Surgical excision remains the treatment of choice, with radiotherapy reserved for challenging cases. While chemotherapy has limited efficacy, complete resection with long-term follow-up is crucial due to the potential for recurrence, especially in malignant forms. This case highlights the importance of including SFT in the differential diagnosis for head and neck lesions and underscores the role of histological analysis in achieving an accurate diagnosis.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 402-405"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of silver nanoparticles using neem and turmeric extract and its antimicrobial activity of plant mediated silver nanoparticles","authors":"Rohit Kumar Singh ,&nbsp;Deepak Nallaswamy ,&nbsp;Shanmugam Rajeshkumar ,&nbsp;Sheeja S. Varghese","doi":"10.1016/j.jobcr.2025.02.005","DOIUrl":"10.1016/j.jobcr.2025.02.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The green synthesis of silver nanoparticles has gained attention for being environmentally friendly and cost-effective. This study investigates the synthesis of silver nanoparticles using neem and turmeric extracts, which serve as natural reducing and capping agents, with a focus on characterizing these nanoparticles and assessing their antimicrobial properties against oral pathogens.</div></div><div><h3>Materials and methods</h3><div>Neem and turmeric extracts were prepared by heating their powdered forms in distilled water, followed by filtration. The extracts were then mixed with a silver nitrate solution, and the reaction was stirred for 24–48 h. The resulting nanoparticles were characterized using UV–Visible spectroscopy, SEM, EDAX, and XRD analysis. The antimicrobial activity of the nanoparticles was tested against four oral pathogens using the agar well diffusion method.</div></div><div><h3>Results</h3><div>Successful synthesis of silver nanoparticles was confirmed by a color change and characterization analyses. UV–Visible spectroscopy showed a peak at 440 nm, indicating nanoparticle formation. SEM revealed spherical and uniform nanoparticles, while EDAX confirmed the presence of silver. XRD analysis showed the crystalline nature of the nanoparticles, with sizes ranging from 4 nm to 14.81 nm. The nanoparticles exhibited significant antimicrobial activity against <em>Staphylococcus aureus</em>, Streptococcus mutans, and Lactobacillus species, but were less effective against Candida albicans.</div></div><div><h3>Conclusion</h3><div>The study demonstrates the effectiveness of neem and turmeric extracts in the green synthesis of silver nanoparticles, which exhibited notable antimicrobial activity. This research underscores the potential of plant-mediated synthesis for developing eco-friendly antimicrobial agents.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 395-401"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of salivary parameters and remineralizing effects of yogurt in counteracting the cariogenic impact of candy consumption: An in vivo study","authors":"Tanvi Shah ,&nbsp;Kripa Dutta ,&nbsp;Swagata Saha ,&nbsp;Manju Raman Nair","doi":"10.1016/j.jobcr.2025.02.007","DOIUrl":"10.1016/j.jobcr.2025.02.007","url":null,"abstract":"<div><h3>Background</h3><div>The consumption of sugary snacks like candies alters the oral environment, increasing the risk of dental caries. This study evaluates changes in salivary pH, calcium, phosphorus, alkaline phosphatase, and total antioxidant capacity (TAC) following the consumption of candies and yogurt.</div></div><div><h3>Aim</h3><div>To compare the impact of candies on the oral environment and assess the effectiveness of rinsing with water versus consuming yogurt in reversing cariogenic changes in saliva.</div></div><div><h3>Materials and methods</h3><div>Baseline saliva samples (5 mL) were collected from 60 children. Participants consumed candies, and saliva was collected 10 min post-consumption. They were divided into two groups: Group 1 rinsed with water, and Group 2 consumed yogurt. Saliva samples were collected at 10, 20 and 30 min post-intervention and analyzed for pH, calcium, phosphorus, alkaline phosphatase, and TAC. Data were analyzed using paired t-tests and post hoc Tukey tests.</div></div><div><h3>Results</h3><div>Candy consumption significantly decreased pH, calcium, phosphorus, and alkaline phosphatase levels (p &lt; 0.001) and increased TAC levels (p &lt; 0.001). Both water rinsing and yogurt consumption reversed these changes. Yogurt showed superior remineralization, with pH, calcium, phosphorus, and alkaline phosphatase levels returning to baseline more effectively than water rinsing (p &lt; 0.001 for all comparisons). TAC levels were also restored more quickly with yogurt (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Candy consumption induces a cariogenic environment. Both water rinsing and yogurt consumption effectively reversed these effects, with yogurt showing enhanced remineralization potential.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 390-394"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental pulp stem cells as a novel antifibrotic therapy for oral submucous fibrosis: An in vitro study","authors":"Snehalata Narvekar ,&nbsp;Shridhar D. Baliga ,&nbsp;Punnya V Angadi","doi":"10.1016/j.jobcr.2025.02.002","DOIUrl":"10.1016/j.jobcr.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder associated with areca nut consumption. It is characterized by progressive fibrosis, trismus, and a significant risk of malignancy, with limited treatment options primarily offering symptomatic relief. Dental pulp stem cells (DPSCs), a type of mesenchymal stem cells (MSCs), have shown potential for modulating fibrotic conditions through their immunomodulatory and regenerative properties. This study evaluates the antifibrotic potential of DPSCs on OSMF fibroblasts in an in vitro model.</div></div><div><h3>Methods</h3><div>DPSCs were isolated from healthy permanent teeth and characterized using flow cytometry for MSC markers (CD73, CD90, CD44, CD105). Fibroblasts were cultured from OSMF biopsy samples and validated through magnetic sorting and morphological analysis. The antifibrotic effects of DPSCs on fibroblasts were evaluated using assays for collagen gel contraction, proliferation, TGF-β1 secretion, and morphological changes. Data were analyzed for statistical significance using appropriate tests.</div></div><div><h3>Results</h3><div>The mean collagen gel size decreased from 3.235 mm (95 % CI: 1.65–4.82 mm) in the control group to 1.00 mm (95 % CI: −0.27 – 2.27 mm) in the DPSC-treated group. Fibroblast viability declined significantly over 72 h (p &lt; 0.05). TGF-β1 secretion was markedly lower in DPSC-treated fibroblasts (339.38 pg/mL vs 637.61 pg/mL, p = 0.000393, Cohen's d = 19.15).</div></div><div><h3>Conclusion</h3><div>DPSCs exhibit strong antifibrotic properties by inhibiting collagen contraction, suppressing fibroblast proliferation, and reducing TGF-β1 secretion. These findings suggest DPSCs as a promising cell-based therapy for OSMF. Further in vivo studies are warranted for clinical translation.</div></div><div><h3>Trial registration number</h3><div>Not applicable.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 383-389"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in orofacial pain conditions: A narrative review","authors":"Mervin Harris ,&nbsp;Saranya Sreekumar ,&nbsp;Bindhu Paul ,&nbsp;Venkitachalam Ramanarayanan ,&nbsp;Suresh Nayar ,&nbsp;Pramod Subash ,&nbsp;Anil Mathew","doi":"10.1016/j.jobcr.2025.01.029","DOIUrl":"10.1016/j.jobcr.2025.01.029","url":null,"abstract":"<div><div>Orofacial pain conditions, including temporomandibular disorder, migraine, dental pain, and trigeminal neuralgia, are complex, multifactorial disorders with significant impacts on patients' quality of life. As understanding of the pathophysiology of these conditions has deepened, the role of molecular and genetic biomarkers in diagnosing, monitoring, and potentially treating orofacial pain has garnered increasing interest. This scoping review provides a comprehensive overview of the current state of research on biomarkers associated with orofacial pain conditions. By analyzing existing literature, we identify key biomarkers linked to inflammation, neural activity, and tissue degradation that are common across multiple conditions, as well as those specific to particular disorders. Our findings underscore the potential of these biomarkers to guide the development of personalized therapeutic strategies. However, the review also highlights the challenges faced by current biomarker research, including heterogeneity in study designs, small sample sizes, and a lack of longitudinal data. Addressing these challenges is critical for translating biomarker research into clinical practice and improving outcomes for patients with orofacial pain.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 365-382"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of rhBMP-2 in mandibular bone regeneration following tooth extraction through HIF-1α and VEGF-A expression: An Immunohistochemical study","authors":"Christian Khoswanto ,&nbsp;Ira Kusuma Dewi","doi":"10.1016/j.jobcr.2025.02.001","DOIUrl":"10.1016/j.jobcr.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>Dentists frequently conduct tooth extractions when there is damage to the tooth or the tissue that supports it. When a tooth is extracted, the alveolar bone will sustain injury. Most of the initial bone volume is lost following the healing phase after extraction. Rehabilitation must start as soon as a tooth is missing, mainly because the alveolar bone is severely damaged during the tooth extraction, particularly in the buccal region where the tooth is removed. Dental implant is one method of replacing lost teeth. One of the most important elements influencing the clinical result of dental implants is a change in the dimension of the alveolar bone. Several bone-grafting techniques, such as socket preservation techniques, have been developed to increase the volume of bone throughout the healing phase after tooth extraction. This study aims to assess the impact rhBMP-2 on creating bone regeneration through VEGF and HIF-1α in the mandibular socket post-extraction in Wistar rats.</div></div><div><h3>Method</h3><div>On the anterior side of the mandible, in the socket area where the tooth was extracted, rhBMP-2 was injected into the socket, and the xenograft material was applied with a syringe. Male, 9-week-old Wistar rats were chosen (n = 30).</div></div><div><h3>Result</h3><div>Our statistical evaluations have revealed a significantly higher VEGF-A and HIF-1α expression post-extraction of the rhBMP-2 and xenograft group compared to other group treatments. These findings are significant as they provide a deeper understanding of the mechanisms involved in bone regeneration post-extraction.</div></div><div><h3>Conclusion</h3><div>Our study suggests that injecting rhBMP-2 into the grafted material and socket extraction during GBR dramatically increases the expression of VEGF-A and HIF-1α. These findings have the potential to significantly impact oral surgery and regenerative dentistry, opening up new possibilities for enhancing bone regeneration techniques.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 359-364"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pulpal response at varying remaining dentin thickness in teeth restored with resin bulk fill composite, conventional glass ionomer cement and silver amalgam: Histomorphometric analysis","authors":"Ankita Agarwal ,&nbsp;Promila Verma ,&nbsp;Rakesh Yadav ,&nbsp;Ramesh Bharti ,&nbsp;Rhythm Bains ,&nbsp;Madhu Kumar ,&nbsp;Dipti Shastri","doi":"10.1016/j.jobcr.2024.12.020","DOIUrl":"10.1016/j.jobcr.2024.12.020","url":null,"abstract":"<div><h3>Objective</h3><div>To compare and evaluate the pulp response to GC glass ionomer cement, SDR plus bulk fill composite and amalgam against gold standard calcium hydroxide cement at varying remaining dentin thickness, in teeth planned for orthodontic extraction.</div></div><div><h3>Method</h3><div>Thirty-eight human premolars were prepared with 2 mm or 2.5 mm depth cavities. They were restored with GC conventional glass ionomer cement, SDR plus bulk fill composite, amalgam, or lined with Dycal and restored with GIC. Two teeth were used as intact controls. After a 7-day interval, the teeth were extracted and processed for histological examination of the pulp and the thickness of the remaining dentin between the cavity floor and pulp tissue.</div></div><div><h3>Results</h3><div>All experimental groups showed some degree of inflammatory response. A significantly higher inflammatory response and more tissue disorganization were observed with SDR bulk fill composite (p &lt; 0.05) compared to Glass ionomer cement, amalgam and Dycal at both cavity depths of 2 mm or 2.5 mm. The mean RDTs ranged from 346 μm to 1025 μm.</div></div><div><h3>Conclusions</h3><div>The study concluded that critical RDT varies for different restorative materials. It was observed that both glass ionomer cement and amalgam demonstrated acceptable biocompatibility when used in deep cavities. At the same time, SDR plus bulk fill composite proved to be the least biocompatible.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 347-354"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tip up - Simplified technique for non-surgical rhinoplasty: A case series","authors":"Cláudia Almeida ,&nbsp;Victor Rogerio ,&nbsp;Gabriela Giro ,&nbsp;Victor Munoz-Lora ,&nbsp;Marcelo Germani","doi":"10.1016/j.jobcr.2025.01.013","DOIUrl":"10.1016/j.jobcr.2025.01.013","url":null,"abstract":"<div><div>Non-surgical nasal rhinoplasty using hyaluronic acid (HA) is a technique that has been widely adopted due to its minimally invasive and reversible nature. Reshaping the nose with HA is becoming increasingly popular for its quick and safe outcomes, serving as an effective alternative for correcting minor nasal deformities. The proposed approach, named the Tip Up (TU) technique, focuses on strategic injection sites, specifically in the Nasal Tip region, Nasal Spine, and Columella, utilizing minimal amounts of the product to minimize risks and enhance the predictability of the results. Procedures are performed under anesthesia without vasoconstrictors to prevent ischemia, and careful selection of the product ensures subtle and precise corrections. This case series details all aspects of the TU technique, highlighting the satisfactory and predictable aesthetic results achieved through a safe and reliable procedure.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 355-358"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioprinting techniques for regeneration of oral and craniofacial tissues: Current advances and future prospects","authors":"Shailesh Varshney ,&nbsp;Anshuman Dwivedi ,&nbsp;Vibha Pandey","doi":"10.1016/j.jobcr.2025.01.019","DOIUrl":"10.1016/j.jobcr.2025.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Regenerative dentistry aims to reinstate, fix, renew, and regrow tissues within the oral and craniofacial domain. Existing regenerative methods are based on insights into tissue biology or disease processes that lead to tissue degradation. However, achieving complete and functional Tissue regeneration remains a primary challenge in real-world medical scenarios.</div></div><div><h3>Aim</h3><div>The review focuses on the application of bioprinting techniques for rejuvenating intricate Oral and craniofacial tissues, such as craniofacial bone, periodontal ligament, cementum, dental pulp, temporomandibular joint cartilage, and whole teeth.</div></div><div><h3>Methods</h3><div>Bioprinting, a cutting-edge technology in regenerative dentistry, strives to create entirely new Functional tissues and organs. This approach merges principles from engineering and biology to produce three-dimensional biologically operational constructs containing bioactive substances, Living cells and cell clusters using automated bioprinters. The review summarizes the outcomes achieved through bioprinting techniques in both in vitro (laboratory experiments) and in vivo (Studies on living organisms) experiments.</div></div><div><h3>Result</h3><div>The emergence of this innovative tissue engineering technology has yielded highly promising outcomes during the experimental stages.</div></div><div><h3>Conclusion</h3><div>These promising experimental results necessitate replication through human clinical trials to ascertain the viability of bioprinting techniques for mainstream clinical implementation in regenerative dentistry.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 331-346"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Effect of oral systemic administration of vitamin D on the rate of maxillary canine retraction: A randomized controlled trial”","authors":"Davender Kumar ,&nbsp;Revathi Mn ,&nbsp;Rekha Sharma ,&nbsp;Ashuma Sachdeva ,&nbsp;Nameksh Raj Bhupali ,&nbsp;Ravinder Solanki","doi":"10.1016/j.jobcr.2025.01.017","DOIUrl":"10.1016/j.jobcr.2025.01.017","url":null,"abstract":"<div><h3>Objective</h3><div>The trial was conducted to determine the effects of systemically delivered Vitamin D (1,25 dihydroxycholecalciferol) on the rate of maxillary canine retraction till the space closure and on the root resorption.</div></div><div><h3>Materials and methods</h3><div>A two-arm parallel randomized controlled trial was conducted in patients with Angle's Class I bimaxillary protrusion requiring at least upper first premolars extraction and distal movement of canine for malocclusion correction. The enrolled patients were randomized and allocated to the experimental group (Oral Vitamin D = 0.25 μg given) and control group (Placebo given). The canine retraction was initiated using nickel-titanium (NiTi) closed coil springs delivering a force of 100 gm per side and Vitamin D levels were monitored at monthly intervals. The patients' casts were digitally scanned and examined for differences in the rate of canine retraction at initial (T0), 4 weeks (T1), 8 weeks (T2), 12 weeks (T3), 16 weeks (T4) and 20 weeks (T5) intervals were calculated. The volumetric root resorption was done on CBCT of the area of interest at T0 and after completion of retraction. Descriptive statistics and paired <em>t</em>-test were used to determine any differences.</div></div><div><h3>Results</h3><div>32 patients (18–24 years) were randomized in the experimental group (n = 16) and control group (n = 16) and no dropout was noted till the end of the study. The results showed a statistically significant increase in the rate of canine retraction in the experimental group as compared to the control group at different time intervals. The differences in the mean canine retraction between group 1 and group 2 at T1-T0, T2-T1, T3-T2, T4-T3, and T4-T0 were 0.28 ± 0.12, 0.29 ± 0.10, 0.31 ± 0.08, 0.37 ± 0.06 and 1.18 ± 0.10 mm respectively. The total mean canine retraction for group 1 was achieved at T4 time interval while it was achieved at T5 interval for group 2. The intergroup comparison of maxillary canine roots showed no statistically significant difference in volumetric root resorption.</div></div><div><h3>Conclusion</h3><div>The active form of vitamin D can be an effective agent to accelerate orthodontic tooth movement (OTM).</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 281-287"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}