Exploring plant-derived carbon dots: Dual-functional nanomaterials for endodontic infections and enhanced bio-imaging

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-08-29 DOI:10.1016/j.jobcr.2025.08.030

Malavika Pradeep , Anju Cecil , Nidhita Suresh , Rajakumar Govindasamy , Natesan Thirumalaivasan

{"title":"Exploring plant-derived carbon dots: Dual-functional nanomaterials for endodontic infections and enhanced bio-imaging","authors":"Malavika Pradeep , Anju Cecil , Nidhita Suresh , Rajakumar Govindasamy , Natesan Thirumalaivasan","doi":"10.1016/j.jobcr.2025.08.030","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Endodontic infections are a major problem of public health, which requires new therapeutic and diagnostic approaches. Carbon dots (CDs) derived from natural sources have great potential as nanomaterials because of their exceptional properties, including biocompatibility and photoluminescence.</div></div><div><h3>Aim</h3><div>An investigation into the therapeutic possibilities of carbon dots derived from long pepper leaves(LCDs) for treating endodontic infections and parallel bio-imaging functionality forms the core research objective.</div></div><div><h3>Method</h3><div>LCDs through a hydrothermal process and checked their properties with FTIR, SEM-EDX, and fluorescence equipment. They tested the cells' acceptance of LCDs along with their resistance to bacteria and ability to enter cells using fibroblast growth tests, the <em>Streptococcus mutans</em> bacteria test, and microscope imaging.</div></div><div><h3>Results</h3><div>LCDs promoted better fibroblast development and endodontic infections healing above previous treatment standards. Biopsy tests show that LCD material kills <em>Streptococcus mutans</em> bacteria easily while also readily up taking cells for potential for Bio-imaging.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that LCD types serve both as a medication for endodontic infections repair and a tool for living tissue observation. we have found a novel approach that will bring new possibilities to both managing endodontic infections and medical imaging techniques.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"Pages 1408-1414"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221242682500209X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Endodontic infections are a major problem of public health, which requires new therapeutic and diagnostic approaches. Carbon dots (CDs) derived from natural sources have great potential as nanomaterials because of their exceptional properties, including biocompatibility and photoluminescence.

Aim

An investigation into the therapeutic possibilities of carbon dots derived from long pepper leaves(LCDs) for treating endodontic infections and parallel bio-imaging functionality forms the core research objective.

Method

LCDs through a hydrothermal process and checked their properties with FTIR, SEM-EDX, and fluorescence equipment. They tested the cells' acceptance of LCDs along with their resistance to bacteria and ability to enter cells using fibroblast growth tests, the Streptococcus mutans bacteria test, and microscope imaging.

Results

LCDs promoted better fibroblast development and endodontic infections healing above previous treatment standards. Biopsy tests show that LCD material kills Streptococcus mutans bacteria easily while also readily up taking cells for potential for Bio-imaging.

Conclusion

The study demonstrates that LCD types serve both as a medication for endodontic infections repair and a tool for living tissue observation. we have found a novel approach that will bring new possibilities to both managing endodontic infections and medical imaging techniques.

查看原文本刊更多论文

探索植物来源的碳点：用于牙髓感染和增强生物成像的双功能纳米材料

牙髓感染是公共卫生的一个主要问题，需要新的治疗和诊断方法。天然来源的碳点（CDs）具有生物相容性和光致发光等优异的性能，作为纳米材料具有巨大的潜力。艾曼研究从辣椒长叶（lcd）中提取的碳点治疗牙髓感染的可能性以及平行生物成像功能形成了核心研究目标。方法采用水热法制备lcd，用FTIR、SEM-EDX和荧光仪检测其性质。他们通过成纤维细胞生长测试、变形链球菌测试和显微镜成像来测试细胞对lcd的接受程度、对细菌的抵抗力和进入细胞的能力。结果slcd对成纤维细胞发育和牙髓感染愈合的促进作用优于原治疗标准。活组织检查表明，LCD材料可以很容易地杀死变形链球菌，同时也很容易吸收细胞，为生物成像提供潜力。结论LCD类型既可作为牙髓感染修复的药物，又可作为活体组织观察的工具。我们已经发现了一种新的方法，将为管理根管感染和医学成像技术带来新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.