Journal of oral biology and craniofacial research最新文献

{"title":"Clinical and patient-reported outcomes of microneedling with ascorbic acid versus scalpel technique for gingival depigmentation: A randomized clinical trial","authors":"Anika Dawar,&nbsp;Jaya Pandey,&nbsp;Vikender Singh Yadav,&nbsp;Dolly Angral,&nbsp;Sumit Kumar Das,&nbsp;Anuppriyanka Ilango,&nbsp;Razia Haidrus","doi":"10.1016/j.jobcr.2026.101530","DOIUrl":"10.1016/j.jobcr.2026.101530","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare gingival depigmentation achieved with microneedling and topical ascorbic acid (MN + AA) versus the conventional scalpel technique, along with evaluation of repigmentation and patient-reported outcomes (PROMs). Gingival thickness (GT) and dermal-gingival pigmentation associations were also explored.</div></div><div><h3>Methods</h3><div>Twenty-six participants with maxillary physiologic gingival hyperpigmentation were randomized (1:1) to scalpel or MN + AA using an automated microneedling pen. Gingival pigmentation was assessed clinically (Dummett-Gupta Oral Pigmentation Index [DOPI], Gingival Pigmentation Index [GPI]); photographically (Pigmented Surface Area [PSA], Lightness [L]), and using a melanin meter (Gingival Melanin Meter Score, GMMS) at baseline, 1, 3, and 6 months. Primary outcome was change in DOPI at 1 month. Gingival Thickness (GT) and Dermal Melanin Meter Scores (DMMS) were recorded.</div></div><div><h3>Results</h3><div>Twenty-three participants completed the study. The scalpel group showed greater reduction in DOPI, GPI, PSA, GMMS, and a greater increase in L at 1 month (<em>P</em> &lt; 0.05). Incomplete depigmentation was observed at some gingival sites with MN + AA. Repigmentation occurred in both groups; DOPI and GMMS were significantly lower in scalpel group at 3 months, with the difference in DOPI persisting at 6 months. Pain, itching, and discomfort scores were modestly higher in the scalpel group, with significant for discomfort on day 3. Color improvement and satisfaction scores were high in both groups. GT increased significantly in the MN + AA at 6 months. DMMS and GMMS were not correlated at any timepoint.</div></div><div><h3>Conclusion</h3><div>Both treatments significantly reduced gingival pigmentation at 1 month, with the scalpel technique showing lower pigmentation intensity at 6 months. Both treatments were well tolerated with favorable PROMs.</div></div><div><h3>Clinical trial registration number</h3><div>CTRI/2024/05/066602 <strong>(</strong>ctri.nic.in<strong>)</strong></div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 5","pages":"Article 101530"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148952759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth factor enriched collagen matrix versus de-epithelialized graft in root coverage procedures - A randomized parallel arm clinical trial","authors":"Sanathana Polimera,&nbsp;Anupama Tadepalli,&nbsp;Harinath Parthasarathy,&nbsp;Priyanka K. Cholan,&nbsp;Lakshmi Ramachandran","doi":"10.1016/j.jobcr.2026.101528","DOIUrl":"10.1016/j.jobcr.2026.101528","url":null,"abstract":"<div><h3>Aim</h3><div>This randomized parallel arm single blinded trial, evaluated the clinical efficacies of de epithelialized free gingival graft (DFGG) and volume stable collagen matrix (VCMX) enriched with injectable platelet-rich fibrin (i-PRF) along with coronally advanced flap (CAF) for the treatment of recession defects. The objectives were to assess and compare changes in recession depth (RD) and root coverage percentage (RC) between the groups.</div></div><div><h3>Materials and methods</h3><div>Forty-five systemically healthy individuals presenting Cairo's RT1/RT2 recession defects in the maxilla were treated either with control (CAF + DFGG, n = 23) or test intervention (CAF + i-PRF + VCMX, n = 22). Parameters such as recession depth (RD) and keratinized tissue width (KTW) were measured at baseline, 6 and 12 months. Mean and complete root coverage percentages (MRC and CRC) were calculated.</div></div><div><h3>Results</h3><div>From baseline to 12 months, a statistically significant reduction in mean RD was observed in both the treatment groups (p &lt; 0.001). At 12 months, the control group demonstrated a MRC of 90.21 ± 28.93% and CRC of 89.13 ± 29.99% and the test group showed a MRC of 81.62 ± 32.03% with CRC of 72.73 ± 45.58%. Intergroup analysis revealed no statistically significant differences in the measured clinical parameters at 6 and 12 months (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Within the limits of this study, volume-stable xenogeneic collagen matrix enriched with i-PRF resulted in similar outcomes to those achieved with de-epithelialized free gingival graft in the treatment of maxillary gingival recession defects.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 5","pages":"Article 101528"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148952757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent-space clustering and feature interpretation in GraphCROC-Encoded periodontal disease, focusing on anterior and posterior bone loss prediction","authors":"Sarvagya Sharma,&nbsp;Deepavalli Arumuganainar,&nbsp;Pradeep Kumar Yadalam","doi":"10.1016/j.jobcr.2026.101529","DOIUrl":"10.1016/j.jobcr.2026.101529","url":null,"abstract":"<div><h3>Background</h3><div>Periodontitis is a widespread inflammatory disease marked by progressive loss of the periodontal ligament and alveolar bone, often leading to tooth loss. Its complex etiology involves dental plaque, the immune response, behavior, and systemic factors such as diabetes. While traditional diagnostic tools such as probing depth, clinical attachment loss, and radiographs are useful, they often miss the heterogeneity of disease progression. Conventional assessments evaluate clinical and radiographic data separately, missing key patterns and interactions. Recent advances in artificial intelligence, especially graph neural networks (GNNs), model the oral cavity as a network of teeth as nodes and relationships as edges. This approach provides a more comprehensive and biologically relevant understanding of periodontal disease.</div></div><div><h3>Methods</h3><div>We developed GraphCROC, a dual-stream model that separately encodes 11 node-level clinical features and five edge-level bone loss metrics, integrating them via a cross-correlation module. The model was trained on data from 90 patients using a clinically weighted reconstruction loss and evaluated against VAE, GCN, and DEC baselines.</div></div><div><h3>Results</h3><div>GraphCROC outperformed all baselines in reconstruction (MAE = 0.402, R² = 0.607) and predicted CAL with the lowest RMSE (0.369). Unsupervised clustering revealed three biologically meaningful disease patterns. Dimensionality reduction revealed clear gradients that represent inflammation and structural loss.</div></div><div><h3>Conclusion</h3><div>GraphCROC successfully reconstructs clinical data, identifies disease subtypes, and supports personalized diagnosis by connecting individual risk factors to spatial bone loss. This graph-based model demonstrates potential for AI-driven periodontal risk assessment and treatment planning.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 5","pages":"Article 101529"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148952760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucin dysregulation in salivary gland tumorigenesis: Diagnostic, prognostic, and therapeutic insights: A systematic review & meta-analysis","authors":"Shreya Chatterjee,&nbsp;Gopikrishnan Vijayakumar,&nbsp;Rahul Anand,&nbsp;Charu Priya,&nbsp;Shanvi Kumari","doi":"10.1016/j.jobcr.2026.101533","DOIUrl":"10.1016/j.jobcr.2026.101533","url":null,"abstract":"<div><h3>Background</h3><div>Salivary gland tumors (SGTs) comprise a heterogeneous group of neoplasms with overlapping histopathological features, making diagnosis and classification challenging Mucins(MUCs) are high molecular weight glycoproteins involved in epithelial differentiation and tumorigenesis which have emerged as potential biomarkers in salivary gland pathology.</div></div><div><h3>Methodology</h3><div>A thorough review and meta-analysis were conducted across PubMed, Scopus, Web of Science, and Embase until February 2025 to elucidate the diagnostic, prognostic, and therapeutic significance of mucin differential expression in benign and malignant SGTs.</div></div><div><h3>Result</h3><div>Twenty-nine articles encompassing 1657 salivary gland cases were included. Data on mucins, their localization, and expression pattern using immunohistochemistry, RT-PCR, or ELISA were evaluated. MUC1 and MUC4 were predominantly expressed in PA and MEC, with MUC1 associated with high-grade MECs and recurrence in PA. MUC4 showed higher expression in low-grade MECs and was diagnostically specific for secretory carcinoma. MUC1 showed high expression in both MEC and PA, but the pooled odds ratios [MEC: OR = 2.23; PA: OR = 0.35] were statistically non-significant (p &gt; 0.05), with moderate heterogeneity (I² = 53% for MEC) and poor subgroup differences. MUC4 had a sensitivity of 81% but exhibited near-zero specificity (0%), and its odds ratio (0.85 [95% CI: 0.17–4.30]) lacked statistical significance.</div></div><div><h3>Conclusion</h3><div>Mucins demonstrate differential expression across salivary gland tumors and may complement histopathological evaluation. However, the current quantitative evidence remains insufficient to support their use as standalone diagnostic biomarkers due to limited specificity and considerable uncertainty in pooled estimates.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 5","pages":"Article 101533"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148952727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endodontic potential of eugenol against Enterococcus faecalis: Antibacterial, antibiofilm, and network pharmacology insights","authors":"Kannika Parameshwari Kannan,&nbsp;Smiline Girija A.S","doi":"10.1016/j.jobcr.2026.101532","DOIUrl":"10.1016/j.jobcr.2026.101532","url":null,"abstract":"<div><h3>Objective</h3><div>The present study aimed to evaluate the antibacterial and antibiofilm efficacy of eugenol against clinical isolates of <em>Enterococcus faecalis</em> obtained from persistent root canal infections and to investigate its potential interactions with virulence-associated target proteins using network pharmacology and molecular docking approaches.</div></div><div><h3>Methods</h3><div>Clinical isolates of <em>E. faecalis</em> were recovered from infected root canal samples and identified using standard microbiological methods. Antibacterial activity of 2% and 4% eugenol was assessed using the agar disc diffusion assay, with further determination of MIC and MBC values using microbroth dilution method. Antibiofilm activity was evaluated using an <em>ex vivo</em> dentinal root canal biofilm model followed by CFU analysis. Potential molecular targets of eugenol were identified further using standard computational tools.</div></div><div><h3>Results</h3><div>4% eugenol exhibited the largest zone of inhibition (23.4 ± 1.4 mm) with the MIC and MBC values at 0.04 mg/mL and 0.4 mg/mL, respectively. In the <em>ex vivo</em> biofilm model, 4% eugenol significantly reduced bacterial colony counts and demonstrated antibiofilm activity comparable to 2% CHX. Network pharmacology analysis identified five potential target proteins, namely pyrG, thyA, accD, tgt, and mtnN and the molecular docking demonstrated favorable binding interactions between eugenol and the selected targets.</div></div><div><h3>Conclusion</h3><div>Eugenol demonstrated significant antibacterial and antibiofilm activity against <em>E. faecalis</em> and the computational analyses suggesting the potential interactions with virulence-associated proteins involved in important metabolic pathways. These findings indicate the potential of eugenol as a plant-derived antimicrobial candidate for endodontic applications; however, further <em>in vivo</em> and toxicity studies are required before clinical application.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 5","pages":"Article 101532"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148952758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Boswellia serrata on cell viability, scratch wound closure, and gene expression in human gingival fibroblasts","authors":"Shima Golmohammadi,&nbsp;Zahra Daneshi,&nbsp;Media Anousheh","doi":"10.1016/j.jobcr.2026.101537","DOIUrl":"10.1016/j.jobcr.2026.101537","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Boswellia serrata</em>, traditionally used for treating inflammatory conditions, has demonstrated anti-inflammatory and antimicrobial properties, but its direct effects on human gingival fibroblasts (HGFs) remain unexplored. Therefore, the aim of this study was to evaluate the effects of methanolic <em>B. serrata</em> extract on human gingival fibroblast cell viability and scratch wound closure and to analyze the expression of key wound healing-related genes.</div></div><div><h3>Materials and methods</h3><div>HGF-1 cells were treated with various concentrations of <em>B. serrata</em> extract. Cell viability was assessed using MTT assay, while in vitro scratch assay was used to evaluate wound closure. Additionally, expression of COL1A1, fibronectin (FN1), TGF-β, and VEGF genes were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR).</div></div><div><h3>Results</h3><div>Concentrations up to 10 μg/mL maintained cell viability above 80% for 72 h. The scratch assay demonstrated significant enhancement of wound closure at 2.5, 5, and 10 μg/mL compared to control (p = 0.012), with the highest numerical wound-closure value observed at 2.5 μg/mL (99.9%). qRT-PCR revealed significant upregulation of COL1A1 (2.68-fold), FN1 (2.12-fold), and VEGF (3.54-fold) (P &lt; 0.001), while the increase in TGF-β expression was non-significant (1.74-fold, P = 0.491).</div></div><div><h3>Conclusion</h3><div><em>Boswellia serrata</em> extract demonstrated favorable effects on HGF-1 cell viability, scratch wound closure, and wound healing-related gene expression at non-cytotoxic concentrations. These findings support further preclinical investigation of <em>B. serrata</em> as a potential adjunctive agent for periodontal wound healing and regeneration.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 5","pages":"Article 101537"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148952726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation mediated Osteoclastogenesis and bone resorption markers in Periodontitis subjects with and without type 2 diabetes- A Cross-sectional study","authors":"Ramalingam Mathangi,&nbsp;Ranganathan Parthasarathy,&nbsp;Nalini Devarajan,&nbsp;S. Bhuminathan,&nbsp;BagavadGita Jayaraman","doi":"10.1016/j.jobcr.2026.101484","DOIUrl":"10.1016/j.jobcr.2026.101484","url":null,"abstract":"<div><h3>Objectives</h3><div>Periodontitis and type2 diabetes are chronic inflammatory diseases resulting in osteoclastogenesis and bone loss<strong>.</strong> This study investigated the effect of type2 diabetes in inflammation mediated osteoclastogenesis invitro along with bone resorption markers in subjects with and without periodontitis.</div></div><div><h3>Methods</h3><div>Whole blood samples were collected from periodontitis subjects with (n = 30) or without T2D (n = 30) and healthy subjects (n = 30). Isolated PBMCs were cultured to study osteoclastogenesis pathways <em>invitro</em>. The prime markers of RANKL signalling pathway, including TRAF6, cFos, NFATc1 and cathepsin K, were analysed by immunoblotting. Serum interleukin 6 (IL6), C- terminal telopeptide of Type I collagen (CTx), tartrate resistant acid phosphatase 5b (TRAP5b) and alkaline phosphatase (ALP) were estimated in all groups.</div></div><div><h3>Results</h3><div>Our results showed that cultured PBMCs from periodontitis and T2D subjects demonstrated a higher number of TRAP positive cells compared to subjects without T2D. IL6, CTx and TRAP5b levels were significantly elevated in T2D with periodontitis, compared to normal subjects with or without periodontitis.</div></div><div><h3>Conclusion</h3><div>This study provides insights on inflammation mediated bone remodelling T2D in periodontitis leading to alveolar bone loss. Understanding this molecular mechanism might provide future translational potential and therapeutic interventions for the osteoclast-related pathological bone diseases such as chronic periodontitis, enabling prevention of tooth loss.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 4","pages":"Article 101484"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13352071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hallermann–Streiff syndrome: A systematic review of the published literature","authors":"Rezhat Abbas,&nbsp;Revathi Krishna,&nbsp;Aarushi Garg","doi":"10.1016/j.jobcr.2026.101485","DOIUrl":"10.1016/j.jobcr.2026.101485","url":null,"abstract":"<div><h3>Background</h3><div>Hallermann–Streiff syndrome is an extremely rare congenital disorder characterized by craniofacial dysmorphism, ocular abnormalities, hypotrichosis, and mandibular hypoplasia, frequently associated with complex airway challenges. No prior systematic review has comprehensively evaluated airway, ophthalmologic, and craniofacial manifestations together. This review synthesizes clinical phenotypes, management strategies, and outcomes from published cases.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Scopus, Embase, and ScienceDirect identified 42 records following PRISMA 2020 guidelines. After screening, 15 studies comprising 32 cases were included. Extracted data included demographics, airway involvement, ophthalmologic findings, craniofacial/orodental anomalies, interventions, and outcomes. Risk of bias was assessed using the JBI checklist for case reports.</div></div><div><h3>Results</h3><div>Airway involvement was reported in over half of cases, ranging from mild obstruction to life-threatening respiratory compromise requiring tracheostomy or specialized anesthetic management. Ophthalmologic abnormalities were common, including congenital cataracts (76%), microphthalmia (65%), and strabismus (59%). Craniofacial anomalies such as micrognathia (88%) and mandibular hypoplasia (82%) were consistently observed. One report documented three-generation familial inheritance. Interventions were multidisciplinary, with most cases showing partial improvement, although severe neonatal respiratory failure remained fatal.</div></div><div><h3>Conclusions</h3><div>Hallermann–Streiff syndrome presents with a characteristic triad of craniofacial, airway, and ophthalmologic abnormalities requiring coordinated multidisciplinary care and long-term follow-up.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 4","pages":"Article 101485"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Regenerative potential of MSC-derived secretomes in radiation-induced xerostomia: Role of SDF-1, IL-10, and VEGF” [J Oral Biol Craniof Res (2026) 16(3) 101453]","authors":"Sri Wigati Mardi Mulyani,&nbsp;Nastiti Faradilla Ramadhani,&nbsp;Deny Saputra,&nbsp;Yunita Savitri,&nbsp;Putri Alfa Meirani Laksanti,&nbsp;Tengku Nebta. Noor","doi":"10.1016/j.jobcr.2026.101493","DOIUrl":"10.1016/j.jobcr.2026.101493","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 4","pages":"Article 101493"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of advanced treatment modalities of dentin hypersensitivity: A systematic review and meta-analysis","authors":"Vrinda Saxena,&nbsp;Saina Shoukath,&nbsp;Payal Saxena,&nbsp;Suruchi Jatol-Tekade,&nbsp;Sweta M. Kumari,&nbsp;Kiran Bachani,&nbsp;Shivam Kamthan","doi":"10.1016/j.jobcr.2026.101500","DOIUrl":"10.1016/j.jobcr.2026.101500","url":null,"abstract":"<div><h3>Background</h3><div>Dentin hypersensitivity (DH) is a prevalent clinical condition characterized by short, sharp pain arising from exposed dentin in response to thermal, tactile, osmotic, or chemical stimuli. Conventional desensitizing agents often provide temporary relief, with inconsistent long-term effectiveness, prompting growing interest in advanced treatment modalities.</div></div><div><h3>Objective</h3><div>To systematically evaluate and compare the efficacy of advanced treatment modalities with conventional or placebo interventions in reducing dentin hypersensitivity in adults.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (Registration ID: CRD420250651753). Electronic searches were performed in PubMed/MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar, with the date of final search being 30 September 2025. Randomized controlled trials involving adults with clinically diagnosed dentin hypersensitivity affecting permanent teeth were included. Advanced interventions such as laser therapy, photobiomodulation, bioactive glass, nano-hydroxyapatite, CPP-ACP, iontophoresis, Resin and varnish systems, were assessed. The primary outcome was reduction in hypersensitivity measured using validated pain assessment scales. Risk of bias was evaluated using the Cochrane RoB 2.0 tool, and quantitative synthesis was performed using a RevMan 5.4. software.</div></div><div><h3>Results</h3><div>Thirty-one randomized controlled trials were included in the qualitative synthesis, and twenty-five studies were eligible for meta-analysis. Advanced treatment modalities demonstrated a statistically significant reduction in dentin hypersensitivity compared with conventional or placebo controls (pooled SMD = −1.02; 95% CI: −1.32 to −0.73; p &lt; 0.001). Laser-based therapies showed the greatest effectiveness, followed by nano-hydroxyapatite and bioactive glass agents. Moderate heterogeneity was observed across studies.</div></div><div><h3>Conclusion</h3><div>Advanced treatment modalities are more effective than conventional desensitizing agents in managing dentin hypersensitivity. Laser therapy provides the most consistent and sustained relief, supporting its clinical use, while further standardized long-term trials are recommended.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 4","pages":"Article 101500"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148776786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}