Journal of oral biology and craniofacial research最新文献

{"title":"Reduction in tongue space/tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma-an exploratory study","authors":"Mahija Janardhanan ,&nbsp;Sandya C.J ,&nbsp;Manu Raj ,&nbsp;Venkitachalam Ramanarayanan ,&nbsp;Rajalakshmi G ,&nbsp;Subramania Iyer K","doi":"10.1016/j.jobcr.2025.04.002","DOIUrl":"10.1016/j.jobcr.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>The occurrence of tongue cancers in young adults with no associated habitual risk factors is emerging as a major health concern. The objective of the study was to investigate the role of low tongue space-tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma.</div></div><div><h3>Methods</h3><div>A case control study was conducted among histopathologically confirmed cases of squamous cell carcinoma of lateral border of the tongue who underwent treatment at the Department of Head &amp; Neck Surgery (case group, n = 50). The patients with normal tongue referred for the evaluation of Magnetic Resonance Imaging of head region for other ailments formed the control group (n = 50). The space available for the tongue and the tongue volume of the study population were measured from the Magnetic Resonance Images (MRI), using in built software, and the mean Tongue space/Tongue volume ratio (TS/TV) of both the case group and the control group were calculated. A comparison of the TS/TV ratio was made between the test group and the control group using independent two sample <em>t</em>-test. The cut off value for TS/TV ratio between the groups was determined using Receiver Operating Characteristic (ROC) Curve method and Odds ratio was calculated by grouping the study population as low or high TS/TV ratio group using the cut off value obtained.</div></div><div><h3>Results</h3><div>A statistically significant variation was observed in the TS/TV ratio between tongue cancer patients and the normal controls with the mean value in normal controls higher than tongue cancer patients (p value = 0.009). The cut off value for TS/TV ratio for the development of tongue cancer was determined as 1.259 using ROC curve and the Odds ratio for malignant transformation in patients with low TS-TV ratio was calculated as 2.6.</div></div><div><h3>Conclusion</h3><div>A significant difference in TS/TV ratio between cases &amp; normal controls observed in our study indicated that a lack of available space for the tongue either due to increase in tongue volume or decrease in tongue space may predispose an individual for the development of tongue cancer.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 718-723"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and correlation of oral cancer phobia and anxiety in oral submucous fibrosis patients: A cross-sectional study","authors":"Ashita Ritesh Kalaskar ,&nbsp;Gauri Ashok Somani ,&nbsp;Ritesh Rambharose Kalaskar","doi":"10.1016/j.jobcr.2025.04.008","DOIUrl":"10.1016/j.jobcr.2025.04.008","url":null,"abstract":"<div><h3>Objective</h3><div>Oral Cancer Phobia and anxiety in patients having premalignant conditions like Oral Submucous fibrosis (OSMF) needs to be evaluated so as to provide an overall effective management to these patients.</div></div><div><h3>Methods &amp; materials</h3><div>Patients having OSMF were tested for oral cancer phobia and anxiety using the validated Marathi translation of CAI and 5-item version of the Spielberger State-Trait Anxiety Inventory (STAI) questionnaire respectively. The correlation was obtained for Oral cancer phobia, anxiety, and socio-demographic status.</div></div><div><h3>Results</h3><div>Cancer phobia and anxiety (mild to severe) were present in all the participants with the majority (65 %) having severe scores and significantly correlated with each other (p value &lt; 0.001). Their scores significantly increased with an increase in grades of OSMF. A co-relation with socio-demographic profiles revealed females to be more affected by severe cancerophobia and anxiety. Patients with less education and housewives had greater levels of cancerophobia and anxiety. Housewives were also more concerned about acquiring cancer.</div></div><div><h3>Conclusion</h3><div>Cancer phobia and anxiety are prevalent in Oral Submucous Fibrosis patients highlighting the significance of identifying and providing psychological therapy as an important part of OSMF management protocol.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 724-728"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The profiling and analysis of gene expression in rat temporomandibular joint disc tissue and its derived cells","authors":"Haruna Kashio ,&nbsp;Rie Takai ,&nbsp;Ayuko Takada ,&nbsp;Yuya Nakao ,&nbsp;Nattakarn Hosiriluck ,&nbsp;Masahiro Iijima ,&nbsp;Yoshihiro Abiko ,&nbsp;Itaru Mizoguchi ,&nbsp;Toshiya Arakawa","doi":"10.1016/j.jobcr.2025.03.018","DOIUrl":"10.1016/j.jobcr.2025.03.018","url":null,"abstract":"<div><h3>Objective</h3><div>The temporomandibular joint (TMJ) disc is composed of a fibrocartilaginous connective tissue. Its dysfunction, resulting from excessive jaw movement, can lead to TMJ disorders. In this study, we aimed to investigate the crucial molecular information regarding the extracellular matrix (ECM), which would be necessary for treating such disorders through TMJ disc regeneration. To achieve this, we compared the gene profiles of TMJ disc tissues, their derived cells, and the periodontal ligament (PDL) in our previous study.</div></div><div><h3>Methods</h3><div>TMJ discs were isolated from male Wistar rats. Cells derived from the TMJ discs were cultured, and mRNA extracted from the disc tissues and derived cells was analyzed for gene profiling via microarray hybridization. Additionally, we compared the ECM expression between the TMJ disc and the PDL.</div></div><div><h3>Results</h3><div>Collagen (types I, II, III, and VI) and proteoglycans (biglycan and fibromodulin) were highly expressed in the TMJ discs. Significant reduction in decorin, fibromodulin and COL2 were observed in the TMJ-derived cells than in the tissue. Type VI collagen was the third most highly expressed in both the TMJ disc and PDL tissues, following types I and III.</div></div><div><h3>Conclusions</h3><div>Collagen types VI and II were prominently expressed, followed by collagen types I and III, in TMJ disc tissues, reflecting the unique functions of the disc. Type VI collagen was highly expressed in both TMJ disc and PDL tissues. Overall, type VI collagen might be a key molecule for TMJ disc regeneration, ensuring elasticity and cushioning, and could provide new insights for TMJ regeneration.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 712-717"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth shape asymmetry in post-canine dentition: Evidence-based morphometric insights","authors":"Srikant Natarajan ,&nbsp;Junaid Ahmed ,&nbsp;Shravan Shetty ,&nbsp;Nidhin Philip Jose ,&nbsp;Sharada Chowdappa ,&nbsp;Sunita Carnelio","doi":"10.1016/j.jobcr.2025.04.010","DOIUrl":"10.1016/j.jobcr.2025.04.010","url":null,"abstract":"<div><h3>Background</h3><div>This study investigates the potential existence of asymmetry in the shape of tooth and location of landmarks of tooth anatomy and its variation between sexes.</div></div><div><h3>Methods</h3><div>Our study evaluated dental symmetry in 160 patients aged 13–20 years, focusing on post-canine dentition. Using 3D geometric morphometrics, the research evaluated the variations in the anatomical landmarks between left and right side.</div></div><div><h3>Results</h3><div>Analysis of the landmarks revealed that 20–30 % of the principal components explained 80 % of the shape variation. No significant difference in centroid size was found between sexes, but significant shape differences were noted in all teeth except the 3-cusp type mandibular second premolar. Asymmetry was more in the premolar segment in the maxillary arch and in the two-cusp type of mandibular second premolar and the mandibular first molar in the mandibular arch.</div></div><div><h3>Conclusion</h3><div>The research underscores the evolutionary advantage of bilateral symmetry and the presence of fluctuating asymmetry, possibly linked to genetic or environmental stressors. It emphasizes the importance of understanding dental asymmetry for effective treatment planning and diagnosis, in restorative dentistry and orthodontics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 703-711"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of proximal contact tightness and contour of bioclear biofit HD versus Composi-tight 3DXR matrix systems in Class-II composite restoration: A randomized clinical study","authors":"Shreya Volety ,&nbsp;Ajay Singh Rao ,&nbsp;Karkala Venkappa Kishan ,&nbsp;Nimisha C. Shah ,&nbsp;Dikshit Solanki ,&nbsp;Geetanjali Jain","doi":"10.1016/j.jobcr.2025.04.005","DOIUrl":"10.1016/j.jobcr.2025.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>To assess proximal contact tightness and contour of two different sectional matrix systems in class-II direct composite restoration using newly designed assessment criteria.</div></div><div><h3>Materials and methods</h3><div>In a double-blinded randomized clinical trial, 62 class-II direct composite restorations were performed in 62 patients using <em>Composi-Tight 3DXR</em> (n = 31) and <em>Bioclear Biofit HD</em> matrix systems (n = 31). Proximal contact tightness and contour were assessed using a self-designed criterion. Statistical analysis utilized <em>Chi-Square</em> and <em>Independent sample t-test</em>, with P &lt; 0.001 considered significant.</div></div><div><h3>Results</h3><div>The mean ± sd score for clinical and radiographical evaluation of proximal contact tightness of the <em>Bioclear Biofit HD</em> group (1.06 ± 0.25) was statistically significant with a p-value (&lt;0.001) compared to the <em>Composi-Tight 3DXR</em> group (2.39 ± 0.72).</div></div><div><h3>Conclusion</h3><div>The study found that the Bioclear Biofit HD matrix system demonstrated better proximal contact and contour than the <em>Composi-Tight 3DXR</em> Sectional Matrix System in Class-II direct composite restorations.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 696-702"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of Microarc Oxidation and sandblasting on the retention of cement-retained implant restorations: An in-vitro study","authors":"Angelin Glory ,&nbsp;Vidhya Jeyapalan ,&nbsp;Jayakrishnakumar Sampathkumar ,&nbsp;Hariharan Ramakrishnan ,&nbsp;Shivakumar Baskaran ,&nbsp;Deepavalli Arumuganainar","doi":"10.1016/j.jobcr.2025.04.004","DOIUrl":"10.1016/j.jobcr.2025.04.004","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim was to compare the impact of two distinct surface treatment methods on implant abutments concerning the retention of implant-supported restorations.</div></div><div><h3>Materials and methods</h3><div>30 implant analogs, individually embedded into blocks of autopolymerizing acrylic resin, were paired with 30 titanium implant abutments and divided into three groups (each, n = 10) based on surface treatment. Group I included untreated implant abutments; group II included abutments treated with sandblasting; and group III comprised abutments treated with Microarc Oxidation. A qualitative surface analysis was conducted using scanning electron microscope. Each abutment was connected to its analog embedded in the resin block. Resin copings were fabricated using rapid additive prototyping (3D printing) and cast into Ni-Cr alloy copings and cemented onto the abutments using zinc-polycarboxylate cement. Test samples were subjected to tensile bond strength (TBS) testing using an Axial-Torsion Servohydraulic Fatigue-Testing System. The results were tabulated and subjected to statistical evaluation.</div></div><div><h3>Results</h3><div>The mean TBS of the cemented cast copings on implant abutments was 4.276 MPa-group I; 6.340 MPa-group II; and 8.117 MPa-group III. Upon comparison, group III demonstrated the highest mean TBS, followed by group II, while group I exhibited the lowest strength. Qualitative surface analysis revealed that the test samples in group II and group III had greater surface roughness compared to those in group I.</div></div><div><h3>Conclusion</h3><div>The surface treatments of implant abutments using sandblasting and Microarc Oxidation enhanced the tensile bond strength of cemented cast copings and, MAO significantly increased retention of cement-retained restorations compared to sandblasting.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 663-669"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis","authors":"Pooja Kurmi ,&nbsp;Prasad Nalabothu ,&nbsp;Shubhasmita Sahoo ,&nbsp;Henu Kumar Verma ,&nbsp;Srinivas Gosla Reddy ,&nbsp;L.V.K.S. Bhaskar","doi":"10.1016/j.jobcr.2025.03.019","DOIUrl":"10.1016/j.jobcr.2025.03.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene.</div></div><div><h3>Materials and methods</h3><div>Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755<strong>)</strong> was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I² statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis.</div></div><div><h3>Results</h3><div>A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I²⁼89 %, and for rs1065755, I²⁼60 %).</div></div><div><h3>Conclusions</h3><div>In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 691-695"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of emotional intelligence on patient-dentist relationships: A questionnaire development, validation and pilot study","authors":"J Deepasakthi ,&nbsp;Arthi Balasubramaniam ,&nbsp;M. Karthik","doi":"10.1016/j.jobcr.2025.04.003","DOIUrl":"10.1016/j.jobcr.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>The Dentist-Patient relationship is a crucial component of successful dental care. Emotional intelligence (EI) has emerged as an important factor that can shape patient experiences and improve the quality of care. The present study was aimed to develop a questionnaire, validate the questionnaire, and assess how EI influences the dentist-patient relationship.</div></div><div><h3>Materials and methods</h3><div>This study was conducted in four phases. First phase was a focus group discussion with preliminary questionnaire development. Phase II was validation of the preliminary questionnaire and phase III was a pilot study that assessed the internal consistency of the preliminary questionnaire. Phase IV was the survey conducted to assess the influence of EI on dentist-patient relationship using the final questionnaire. A cross-sectional survey was conducted with 200 dentists in the month of September 2024.</div></div><div><h3>Results</h3><div>The CVI and CVR of the final questionnaire was found to be &gt; 0.8 with κ = 81 % suggestive of good intra-rater agreement. The internal consistency of the final questionnaire was good with Cronbach's α value &gt; 0.7. More than 40 % of the participants had an opinion that emotional intelligence helps in making ethical decisions in dental practice. Also, 41.5 % of the dentists suggested for a formal training in emotional intelligence in dental schools.</div></div><div><h3>Conclusion</h3><div>By fostering trust, improving communication, and managing emotional challenges, dental professionals can enhance the quality of care and patient experiences. Implementing EI-focused modules into dental curricula can better prepare future dentists to manage the emotional and psychological aspects of patient care.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 670-676"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of dentin remineralization with Nano-amorphous calcium phosphate-modified bioactive restoratives","authors":"Garima Tyagi ,&nbsp;Sakshi Jain ,&nbsp;Shivani Deshwal ,&nbsp;Shubham Singh ,&nbsp;Nikita Poonia ,&nbsp;Shivangi Sharma","doi":"10.1016/j.jobcr.2025.04.009","DOIUrl":"10.1016/j.jobcr.2025.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>Modern caries management emphasizes minimally invasive techniques to promote remineralization through a balanced pH and mineral ion availability. Bioactive restorative materials, including giomer (Beautiful II, SHOFU Dental GmbH, Japan), and ACTIVA BioACTIVE (Pulpdent Corp., Watertown, MA, USA), release fluoride, calcium, and phosphate to enhance dentin remineralization. Nano-amorphous calcium phosphate (NACP) is a highly reactive mineral with proven remineralization capabilities due to its high surface area and solubility. The synergistic effects of NACP and the bioactive materials remain underexplored. This study evaluates the remineralization potential of giomer and ACTIVA BioACTIVE with and without NACP integration using energy-dispersive X-ray spectroscopy (EDX) microanalysis and Knoop hardness number (KHN) assessments.</div></div><div><h3>Materials and methods</h3><div>Four restorative composite materials: Beautifil II, Beautifil II with NACP, ACTIVA BioACTIVE, and ACTIVA BioACTIVE with NACP, were evaluated on demineralized dentin cavities created in non-carious molars. The mineral content (Ca, P, F) was analyzed via EDX, and the microhardness was measured using KHN. Statistical analyses included analysis of variance (ANOVA) and post hoc Tukey tests.</div></div><div><h3>Results</h3><div>NACP significantly increased calcium and phosphate deposition, with ACTIVA BioACTIVE with NACP demonstrating the highest remineralization (Ca/P ratio: 2.16). Fluoride intensities were higher in the giomer-based materials, promoting fluorapatite formation. KHN analysis revealed that Beautifil II with NACP exhibited the highest hardness, whereas ACTIVA BioACTIVE with NACP showed reduced hardness despite enhanced mineral content.</div></div><div><h3>Conclusion</h3><div>The incorporation of NACP into giomer and ACTIVA BioACTIVE facilitated the accumulation of calcium and phosphate ions, leading to enhanced mineralization.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 684-690"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy in improving the interincisal mouth opening in oral submucous fibrosis: Meta-analysis","authors":"Ashish Bodhade ,&nbsp;Alka Dive ,&nbsp;Monal Yuwanati ,&nbsp;Amol Gadbail ,&nbsp;Dhara Dwivedi","doi":"10.1016/j.jobcr.2025.04.007","DOIUrl":"10.1016/j.jobcr.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Oral submucous fibrosis (OSMF) is a chronic, irreversible collagen metabolic disorder resulting in progressive reduction of mouth opening due to submucosal fibrosis. Currently, the benefit of interincisal mouth opening (IMO) has been attributed to physical therapy. This meta-analysis aimed to find evidence about effectiveness of physiotherapy in increasing of IMO.</div></div><div><h3>Method</h3><div>Literature search was conducted in Scopus, Web of Science, and PubMed databases using \"Oral submucous fibrosis\", \"OSMF\", \"OSF”, “treatment”, “treatment modalities\", \"physiotherapy devices\", “mouth opening exercise device”, “mouth opening”, “mouth opening device”, and \"physiotherapy\" search terms to find the relevant studies published till March 2024. Studies evaluating the effectiveness of physiotherapy alone or in combination in improvement of IMO pre-post intervention in OSMF patients were included. Random-effect analysis was carried out to obtain the pooled IMO. Heterogeneity and publication bias was assessed using the <em>I</em>² and funnel plot. The main outcome variable was increase in IMO which was measured on linear scale.</div></div><div><h3>Results</h3><div>20 studies included in meta-analysis. Physiotherapy alone was found to be effective in improving IMO (4 studies; MD 1.19 [0.18, 2.20]). Further, addition of physiotherapy along with ultrasound (US) (3 studies; MD 3.96 [1.50, 6.42]), medicinal therapy including herbal (13 studies; MD 8.35 [5.18, 11.51]) and surgery (8 studies; MD 21.84 [18.29, 25.38]) improves the IMO.</div></div><div><h3>Conclusion</h3><div>There is evidence of effectiveness of physiotherapy in improving the IMO. However, evidence need to be substantiated with stringent methodology which is lacking in most of studies.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 677-683"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}