Journal of oral biology and craniofacial research最新文献

{"title":"Atypical coronoid process displacement in ZMC Trauma: Technical considerations and management algorithm – A technical note","authors":"Jishnu Mohan, Virendra Singh, Ankita Dahiya, Rajesh Chauhan, Rashmi Bawane","doi":"10.1016/j.jobcr.2025.05.003","DOIUrl":"10.1016/j.jobcr.2025.05.003","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 775-778"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute oral toxicity and mucosal irritation of a mouthwash containing chlorhexidine and chlorine dioxide in animal models","authors":"Thao Thi Phuong Tran ,&nbsp;Lam Nguyen Le ,&nbsp;Thanh Van Tran ,&nbsp;Thuy Anh Vu Pham","doi":"10.1016/j.jobcr.2025.04.013","DOIUrl":"10.1016/j.jobcr.2025.04.013","url":null,"abstract":"<div><h3>Background</h3><div>Halitosis is primarily caused by bacterial activity in the oral cavity. Chlorhexidine (CHX) is a widely used antimicrobial mouthwash but has notable side effects. Chlorine dioxide (ClO₂) is a potent oxidizer that may reduce the required CHX concentration while preserving efficacy. This study evaluates the acute systemic toxicity and local mucosal irritation of a CHX-ClO₂ combination in animals, to determine its safety for potential human use.</div></div><div><h3>Material and method</h3><div>Mice were administered a single oral dose of a mouthwash containing 0.5 % CHX and 2.5 % ClO₂. Clinical signs, mortality, and body weight were monitored over 14 days. In a separate test, rabbit buccal mucosa was exposed to the same mouthwash daily for 14 days. Macroscopic and microscopic irritation scores were recorded according to ISO 10993–23:2021.</div></div><div><h3>Result</h3><div>No mortality or significant clinical toxicity was observed in mice. Only transient ocular irritation occurred in 30 % of the test group.</div></div><div><h3>Conclusion</h3><div>The combination of 0.5 % CHX and 2.5 % ClO₂ appears safe in mice and causes negligible irritation in rabbit oral mucosa.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 770-774"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of scalpel and diode laser techniques in gingival depigmentation: A split-mouth randomized controlled trial with RGB photographic Quantification","authors":"Devadharshini Chandrasekar,&nbsp;Pavithra Gopalakrishnan,&nbsp;Vijayalakshmi Rajaram,&nbsp;Burnice Nalina Kumari Chellathurai,&nbsp;Anitha Logaranjani,&nbsp;Jaideep Mahendra,&nbsp;Nikita Ravi","doi":"10.1016/j.jobcr.2025.05.001","DOIUrl":"10.1016/j.jobcr.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Gingival aesthetics, integral to a smile's attractiveness, can be significantly impacted by pigmentation. Melanin, produced by melanocytes, contributes to this pigmentation, which can be addressed through various depigmentation techniques. This study aims to compare the efficacy of conventional scalpel and diode laser methods for gingival depigmentation using RGB photographic analysis.</div></div><div><h3>Materials and methods</h3><div>This split-mouth, randomized controlled trial involved five participants with bilateral maxillary gingival hyperpigmentation. One sextant per participant was treated with a scalpel (Group 1), and the contralateral sextant was treated with a diode laser (940 nm) (Group 2). Parameters assessed included intraoperative bleeding, postoperative pain (VAS), wound healing (Wound Healing Index), and pigmentation (Dummett Oral Pigmentation Index). RGB photographic analysis was used to quantify colour changes.</div></div><div><h3>Results</h3><div>No significant difference was observed in intraoperative bleeding between the groups (p = 0.31). Postoperative pain was significantly lower in Group 2 on Day 1 (p = 0.01), though this difference was not significant by Day 7 (p = 0.25). Wound healing scores were comparable at 7 days and 6 months but were significantly better in Group 2 at 12 months (p = 0.01). Pigmentation reduction was significantly greater in Group 2 at 6 months (p = 0.01), but the difference was not significant at 12 months (p = 1.00). RGB analysis revealed that Group 2 achieved superior control of pigmentation, with significant differences in red, green, and blue values at multiple time points (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Diode laser treatment (Group 2) demonstrated superior aesthetic outcomes and reduced postoperative pain compared to the scalpel technique (Group 1), along with more effective long-term pigmentation control. RGB analysis provided valuable objective data supporting these findings.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 763-769"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the cytotoxicity, apoptotic effects, and remineralization potential of recent bioceramic-based root canal sealers","authors":"Manar M. Galal ,&nbsp;Amira Galal Ismail ,&nbsp;Yousra Nashaat ,&nbsp;Tamer M. Hamdy","doi":"10.1016/j.jobcr.2025.05.002","DOIUrl":"10.1016/j.jobcr.2025.05.002","url":null,"abstract":"<div><h3>Background</h3><div>This study is aimed at evaluating the cytotoxicity, apoptosis/necrosis, and calcium ion release of ADseal (a resin-based sealer) and two recently introduced bioceramic-based root canal sealers, which are VDW.1 seal bioceramic and Fill Root ST.</div></div><div><h3>Methods</h3><div>The cellular responses were studied in human periodontal ligament stem cells (hPDLSCs). Four root canal sealer extracts concentrations (100 %, 50 %, 25 %, and 12.5 %) were assessed for cell viability using the cell viability MTT essay and after 24 h, 48 h, and 7 days for all concentrations. To determine the effect of materials on apoptosis and necrosis, flow cytometry analysis was used. Calcium ion release was evaluated after 14 days of storage in distilled water using optical emission spectroscopy (ICP-OES). A two-way ANOVA was used for the statistical analysis of the acquired results.</div></div><div><h3>Results</h3><div>Fill Root ST and VDW.1 seal bioceramic showed the highest amount of cell viability compared to ADseal sealer. Moreover, Fill Root ST, followed by VDW.1 seal bioceramic, demonstrated decreased cell apoptosis and necrosis. Moreover, VDW.1 seal bioceramic showed the highest calcium ion release, followed by Fill Root ST. ADseal sealers showed the lowest calcium ion release compared to bioceramic-based root canal sealers.</div></div><div><h3>Conclusions</h3><div>Based on the results of this study, in terms of cytotoxicity, apoptosis/necrosis, and remineralization ability, bioceramic-based root canal sealers were more biocompatible than ADseal resin-based sealers.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 757-762"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dentin thickness preservation and the efficiency of instrumentation between traditional and guided endodontic access in mandibular central incisors","authors":"Pooja R. Kesharani ,&nbsp;Shalini D. Aggarwal ,&nbsp;Nishtha K. Patel ,&nbsp;Jhanvi Patel ,&nbsp;Ankita Bansal ,&nbsp;Naman Patel","doi":"10.1016/j.jobcr.2025.04.011","DOIUrl":"10.1016/j.jobcr.2025.04.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Tooth substance loss during endodontic treatment is a major concern, especially in mandibular incisors due to their minimal tooth volume. Template-guided access cavities help preserve dentin and improve instrument centering. This in vitro study compares remaining dentin thickness (RDT) and centering ability of rotary instruments using both conventional and template-guided approaches in mandibular incisors.</div></div><div><h3>Objective</h3><div>Comparative in vitro CBCT study on remaining dentin thickness and centering ability of rotary instrumentation in mandibular incisors using conventional vs. template-guided access cavity preparation.</div></div><div><h3>Methodology</h3><div>Pre-treatment CBCT scans were taken of 80 mandibular incisors, to evaluate the existing dentin thickness and these were then divided into 2 groups of 40 teeth each. Conventional endodontic access cavities were made in Group −1, and guided access openings were done in Group – 2. Post-operative CBCT scans were taken to measure the RDT canal centering ability of each approach.</div><div>The data was examined using a one-way analysis of variance, followed by Tukey's post-hoc test for multiple pairwise comparisons, with a significance level set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>The mean RDT was significantly higher in the group where a template-guided access opening was done. The statistical difference for RDT amongst both the experimental groups was highly significant at the Cemento-Enamel Junction and 9 mm from the root apex. Statistically significant results were obtained 6 mm level and insignificant result was obtained at 3 mm level from root apex. No significant differences in the centering ability ratio were observed between the Traditional Endodontic Cavity (TEC) and Guided Endodontic Cavity (GEC) at any level.</div></div><div><h3>Conclusion</h3><div>Pericervical dentin was preserved more in guided access cavity preparation. The design of the access cavity preparation did not impact the centering ratio of the instruments used for shaping the root canals.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 749-756"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between cephalometric analyses in diagnosing the dento-skeletal characteristics of malocclusion","authors":"J. Monisha,&nbsp;Ulaganathan Sangeetha,&nbsp;Bhaskar Nivethitha,&nbsp;Balasubramanian Madhan","doi":"10.1016/j.jobcr.2025.04.012","DOIUrl":"10.1016/j.jobcr.2025.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Conflicting results from different cephalometric analyses is a common problem with broader implications but has not received due attention. This study evaluated the agreement between common cephalometric analyses in diagnosing the essential dento-skeletal characteristics of malocclusion.</div></div><div><h3>Material and methods</h3><div>A total of 125 lateral cephalograms were analyzed digitally using Downs, Steiner, Wits, Tweed, Bjork, Ricketts, and McNamara analysis. The diagnosis of sagittal jaw relation (Class 1/2/3), maxillary and mandibular positions (Orthognathic/Prognathic/Retrognathic), growth pattern (Normodivergent/Hypodivergent/Hyperdivergent), and upper and lower incisors positions (Normal/Proclined/Retroclined) were established based on each analysis. The extent of agreement between the analyses was assessed using Kappa statistics.</div></div><div><h3>Results</h3><div>The overall agreement between analyses was moderate for sagittal jaw relationship [k = 0.41 (0.37-0.45)], fair for growth pattern [k = 0.24 (0.20-0.27)], mandibular position [k = 0.25, (0.20-0.30)], upper incisor (k = 0.38, CI = 0.32-0.44) and lower incisor [k = 0.21 (0.17-0.25)] positions, and only slight for maxillary position [k = 0.18 (0.13-0.23)]. For pairwise comparisons of analyses, the agreement was moderate to substantial for the sagittal jaw relationship (except for comparisons involving McNamara analysis) and slight to moderate for other variables. Also, the diagnosis of normal dentofacial relationships (Class 1 and normodivergent skeletal pattern, orthognathic jaw positions, and normal incisor positions) was less consistent than those of deviant subgroups.</div></div><div><h3>Conclusions</h3><div>The agreement between the cephalometric analyses evaluated was moderate for sagittal jaw relation and only fair for most other dento-skeletal characteristics. McNamara's analysis showed less agreement with others. These highlight the need for a more cautious and scientific approach to Cephalometrics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 744-748"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Antibiofilm efficiency of silver and copper nanoparticle incorporated calcium hydroxide as an intracanal medicament: An in vitro study” [Journal of Oral Biology and Craniofacial Research 15 (2025) (2) 319–324]","authors":"Murali H. Rao ,&nbsp;Krishnan Rajkumar ,&nbsp;Gopal Pavithra ,&nbsp;Ramya Ramadoss ,&nbsp;Suryanarayanan Shankar ,&nbsp;Krishnamachari Janani ,&nbsp;Kumar Chandan Srivastava ,&nbsp;Deepti Shrivastava ,&nbsp;Dinesh Rokaya","doi":"10.1016/j.jobcr.2025.02.009","DOIUrl":"10.1016/j.jobcr.2025.02.009","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 659-661"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the biological activity and setting dynamics of a novel polydopamine-based root repair material","authors":"Lakshmi Nidhi Rao ,&nbsp;Aditya Shetty ,&nbsp;Arun M. Isloor ,&nbsp;Sooraj Nayak ,&nbsp;Mohana Kumar ,&nbsp;Jayaprakasha Shetty K ,&nbsp;Muttanna Venkatesh","doi":"10.1016/j.jobcr.2025.04.001","DOIUrl":"10.1016/j.jobcr.2025.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Root perforation represents a significant complication in endodontics, compromising the structural integrity of the tooth. Effective repair are critical to mitigating the associated risks and preserving long-term dental function. Despite extensive research, the ideal repair material that fulfills all requisite biological and mechanical properties remains elusive.</div></div><div><h3>Methodology</h3><div>This study introduces a novel polydopamine based repair material designed to address the limitations of existing materials. The material was characterized using field emission scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, transmission electron microscopy, zeta potential, and particle size analysis. The material's initial and final setting times were evaluated using a Gilmore needle apparatus. Biocompatibility was assessed via the MTT assay, while bioactivity was quantified through calcium ion release analysis. Comparative evaluations were conducted against ProRoot MTA, a commercially available standard in root repair.</div></div><div><h3>Results</h3><div>The findings revealed no statistically significant differences in cytotoxicity (P &gt; 0.05) between the experimental material and ProRoot MTA, affirming the biocompatibility of both. However, the experimental material demonstrated a significantly faster set (P &lt; 0.001) than ProRoot MTA, a critical advantage in clinical applications. the inclusion of calcium chloride and bioactive glass enhanced calcium ion release, with the experimental material showing significantly higher levels at 7 days.</div></div><div><h3>Conclusion</h3><div>The polydopamine-bioactive glass composite exhibited favorable biological activity, superior setting dynamics, and enhanced bioactivity, positioning it as a promising candidate for perforation repair. These results lay the groundwork for further research and potential clinical translation, offering a viable solution to a longstanding challenge in endodontics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 737-743"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different curcumin concentrations on human periodontal ligament fibroblast adhesion and proliferation on periodontally involved root surfaces: In-vitro study","authors":"Amina Fouad Farag ,&nbsp;Hala H. Yassin ,&nbsp;Ahmed Y. Gamal ,&nbsp;Noorhan El Badawi ,&nbsp;Mahetab M. Abdalwahab","doi":"10.1016/j.jobcr.2025.04.006","DOIUrl":"10.1016/j.jobcr.2025.04.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Periodontopathic endotoxins infiltrate root surface and prevent cellular adhesion to tooth surfaces. Naturally occurring curcumin has anti-inflammatory, antioxidant and antibacterial qualities that promote fast wound healing by increasing fibroblast cell proliferation and migration in concentration-dependent manner.</div></div><div><h3>Objectives</h3><div>This study was conducted to evaluate the effect of 0.12 %, 1 % and 2 % curcumin concentrations on PDL cell adhesion, viability and proliferation to periodontally affected root surfaces.</div></div><div><h3>Materials and methods</h3><div>20 periodontally affected teeth sectioned into root samples were included. PDL fibroblasts were collected from freshly extracted teeth, cultured and expanded. PDL fibroblast (1 × 10⁵ cells/ml) was seeded on curcumin coated root samples in different concentrations. Study samples were divided into 4 groups: G1 (0.12 % of curcumin paste), G2 (1 % curcumin paste), G3 (2 % curcumin paste) and G4 (control/unconditioned group). All samples were investigated by SEM and MTT assay.</div></div><div><h3>Results</h3><div>G3 showed highest viability and cell proliferation compared to other groups where well defined multilayered adherent cells covering entire surface with totally flat polyhedral bodies with long cytoplasmic extensions and little or no bacterial colonization.</div></div><div><h3>Conclusion</h3><div>Curcumin 2 % provides optimal stimulation of cellular attachment, viability, proliferation and antibacterial effects over periodontitis affected root surfaces.</div></div><div><h3>Clinical relevance</h3><div>Determination of optimal curcumin concentration in this study revealed 2 % concentration produced highest levels of PDL cellular attachment, viability, proliferation and antibacterial action over root surfaces afflicted by periodontitis. Therefore, the use of that optimal curcumin concentration as adjunctive to non-surgical periodontal therapy may modify the periodontal pocket ecology to improve the healing of periodontal tissues.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 729-736"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction in tongue space/tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma-an exploratory study","authors":"Mahija Janardhanan ,&nbsp;Sandya C.J ,&nbsp;Manu Raj ,&nbsp;Venkitachalam Ramanarayanan ,&nbsp;Rajalakshmi G ,&nbsp;Subramania Iyer K","doi":"10.1016/j.jobcr.2025.04.002","DOIUrl":"10.1016/j.jobcr.2025.04.002","url":null,"abstract":"<div><h3>Background</h3><div>The occurrence of tongue cancers in young adults with no associated habitual risk factors is emerging as a major health concern. The objective of the study was to investigate the role of low tongue space-tongue volume ratio as a risk factor for oral tongue squamous cell carcinoma.</div></div><div><h3>Methods</h3><div>A case control study was conducted among histopathologically confirmed cases of squamous cell carcinoma of lateral border of the tongue who underwent treatment at the Department of Head &amp; Neck Surgery (case group, n = 50). The patients with normal tongue referred for the evaluation of Magnetic Resonance Imaging of head region for other ailments formed the control group (n = 50). The space available for the tongue and the tongue volume of the study population were measured from the Magnetic Resonance Images (MRI), using in built software, and the mean Tongue space/Tongue volume ratio (TS/TV) of both the case group and the control group were calculated. A comparison of the TS/TV ratio was made between the test group and the control group using independent two sample <em>t</em>-test. The cut off value for TS/TV ratio between the groups was determined using Receiver Operating Characteristic (ROC) Curve method and Odds ratio was calculated by grouping the study population as low or high TS/TV ratio group using the cut off value obtained.</div></div><div><h3>Results</h3><div>A statistically significant variation was observed in the TS/TV ratio between tongue cancer patients and the normal controls with the mean value in normal controls higher than tongue cancer patients (p value = 0.009). The cut off value for TS/TV ratio for the development of tongue cancer was determined as 1.259 using ROC curve and the Odds ratio for malignant transformation in patients with low TS-TV ratio was calculated as 2.6.</div></div><div><h3>Conclusion</h3><div>A significant difference in TS/TV ratio between cases &amp; normal controls observed in our study indicated that a lack of available space for the tongue either due to increase in tongue volume or decrease in tongue space may predispose an individual for the development of tongue cancer.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 718-723"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}