Journal of oral biology and craniofacial research最新文献

{"title":"Natural biomaterial approach: Synergistic effects of cocoa and aloe vera in hydrogel-based bone regeneration: An in vitro study","authors":"Feni Istikharoh ,&nbsp;Hidayat Sujuti ,&nbsp;Edi Mustamsir","doi":"10.1016/j.jobcr.2025.06.009","DOIUrl":"10.1016/j.jobcr.2025.06.009","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the characterization of cacao and aloe vera as natural hydrogel materials.</div></div><div><h3>Materials and methods</h3><div>Natural hydrogel includes fermentation of cacao beans for 5 days, grinding into a paste, and separating cacao butter. Aloe vera extract was obtained through the maceration method with 70 % ethanol. Samples were divided into four groups with different concentrations and sterilized using gamma radiation. Tests included a porosity test using the liquid displacement method, a biodegradability test with PBS pH 7.4, a viscosity test using a Stormer viscometer, and an antibacterial test against <em>Aggregatibacter actinomycetemcomitans</em>. Statistical analysis used one-way ANOVA with a significance of p &lt; 0.05.</div></div><div><h3>Results</h3><div>The hydrogel porosity of the four groups was within the ideal range for bone regeneration (75–86 % ± 0.02) without significant differences. Hydrogel with aloe vera content of 12.5 mg/ml showed the highest degradation on days 1 (65.1 % ± 1.01), day 7 (49.56 % ± 3.58), and day 14 (77.91 % ± 5.15). The higher the aloe vera content, the lower the viscosity of the hydrogel. Aloe vera-cocoa hydrogel has antibacterial properties that can inhibit the growth of A. actinomycetemcomitans bacteria, with effectiveness starting from a concentration of 3.125 mg/ml.</div></div><div><h3>Conclusion</h3><div>Hydrogel of aloe vera – alkalized cacao demonstrates optimal porosity, biodegradability, and viscosity, which can be a candidate for socket preservation material to prevent alveolar bone resorption after tooth extraction.</div></div><div><h3>Clinical significance</h3><div>Alkalized aloe vera-cocoa hydrogel can be a promising alternative socket preservation material after tooth extraction. This material has optimal porosity, controlled biodegradability, suitable viscosity, and antibacterial activity, thus potentially preventing alveolar bone resorption in a more economical and biocompatible manner.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 880-887"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of twin-block appliance on quality of life in OSA children with class 2 malocclusion and mandibular retrognathia","authors":"Maen Zreaqat ,&nbsp;Sahal Alforaidi ,&nbsp;Rozita Hassan","doi":"10.1016/j.jobcr.2025.06.003","DOIUrl":"10.1016/j.jobcr.2025.06.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Twin block has been proposed as a potential oral appliance for the treatment of obstructive sleep apnea (OSA) in children with class 2 skeletal malocclusion. This study aimed to evaluate the impact of twin block appliance on quality of life in children with OSA.</div></div><div><h3>Materials and methods</h3><div>This case series study comprised 47 growing OSA children with Class 2 skeletal malocclusion and mandibular retrognathia aged 10–12 years. Patients were treated with a functional twin block appliance and the quality of life was assessed using the OSA-18 questionnaire, which was administered before appliance insertion and 30 days after the end of treatment. Additionally, a second standard overnight polysomnography (PSG) was performed to determine changes in respiratory parameters.</div></div><div><h3>Results</h3><div>All domains of the OSA-18 questionnaire showed significant changes (P &lt; 0.025), except for physical suffering domain (P = 0.075). The mean total scores of the OSA-18 questionnaire decreased from 81.55 to and 53.07 scores (28.49 scores, P &lt; 0.001). At the end of the treatment, the apnea-hypopnea index decreased significantly by 4.53 events/h (74.0 %), P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The twin block appliance resulted in a significant improvement in four of the five domains of the OSA-18 questionnaire, with a positive impact on the quality of life in OSA children with Class 2 skeletal malocclusion. Patients showed significant improvements in respiratory sleep parameters and parent-reported symptoms.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 864-868"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of hydrogel therapy to improve hypoxic environment of periodontal tissues and promote periodontal regeneration","authors":"Jing Zhou ,&nbsp;wen lei Wu ,&nbsp;Yu Liu","doi":"10.1016/j.jobcr.2025.06.005","DOIUrl":"10.1016/j.jobcr.2025.06.005","url":null,"abstract":"<div><div>Periodontitis is a hypoxic infectious disease. When periodontal tissues are affected by disease and the microenvironment becomes inflamed, the release of local inflammatory factors and increased tissue metabolism lead to an imbalance between oxygen supply and demand. This inflammatory environment disrupts blood microcirculation, causing the local periodontal tissue to enter a relatively ischemic and hypoxic state. Deep periodontal pockets and periodontal pathogenic bacteria further reduce the oxygen tension in periodontal tissues, exacerbating the progression of periodontitis. Current treatment strategies for improving the inflammatory microenvironment include mechanical therapy and systemic or localized antibiotic administration. However, these existing methods fail to effectively restore the microbiota balance, ensure sustained drug release, or maintain drug presence at the lesion site. Hydrogels, due to their low cytotoxicity, excellent water retention properties, and ability to control drug release, serve as an effective drug delivery pathway that supplies oxygen to inflammatory sites. This article reviews the mechanisms and recent advancements in using hydrogel-based therapies to improve the hypoxic microenvironment of periodontal tissues, thereby promoting periodontal regeneration, and provides clinical insights for future applications in periodontal regeneration.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 869-879"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in-vitro exploration of the antifibrotic activity of Naringenin: A potential therapeutic agent for oral submucous fibrosis management","authors":"S. Samyuktha Aarthi ,&nbsp;Deepak Pandiar ,&nbsp;Raghunandhakumar Subramanian ,&nbsp;Reshma Poothakulath Krishnan","doi":"10.1016/j.jobcr.2025.06.006","DOIUrl":"10.1016/j.jobcr.2025.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Oral submucous fibrosis (OSMF) is a precancerous condition primarily associated with betel nut chewing. Naringenin, a flavonoid found in citrus fruits, has been demonstrated to show antifibrotic effects in various fibrosis models. The present study was conducted to investigate the potential antifibrotic properties of naringenin in Human gingival fibroblasts (HGFs) exposed to arecoline.</div></div><div><h3>Materials and methods</h3><div>Naringenin was extracted from grapefruit peel using methanol and characterized via Gas Chromatography-Mass Spectrometry (GC-MS). HGFs were cultured in Dulbecco's Modified Eagle Medium and treated with arecoline to induce fibrosis. The cells were then exposed to naringenin at varying concentrations. Cytotoxicity was assessed using the MTT assay, while the expression of fibrotic markers was quantified using real-time polymerase chain reaction (PCR). Additionally, Masson's trichrome staining was performed to evaluate the collagen deposition aided by An in-silico pharmacological network analysis.</div></div><div><h3>Results</h3><div>GC-MS confirmed the presence of naringenin as a major bioactive compound in grapefruit peel extract. Naringenin significantly improved cell viability in arecoline-treated HGFs. It was found that naringenin markedly downregulated the expression of fibrotic markers, as compared to the arecoline-only group. Histopathological analysis demonstrated a reduction in collagen deposition following naringenin treatment. Pharmacological network analysis identified potential pathways targeted by naringenin, including TGF-β, PI3K-Akt, and MAPK signaling, with hub genes such as MMP9 and TGFB1 playing central roles.</div></div><div><h3>Conclusion</h3><div>Naringenin exhibits promising antifibrotic activity in arecoline-induced fibrosis in HGFs, potentially through modulation of key fibrotic signaling pathways. These findings highlight its potential role as a therapeutic agent for OSMF management.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 849-857"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping hard tissue maturation: the role of Gallego stain in differential staining","authors":"Shweta Mary Reddy,&nbsp;Suganya Panneer Selvam,&nbsp;Ramya Ramadoss,&nbsp;Sandhya Sundar","doi":"10.1016/j.jobcr.2025.06.004","DOIUrl":"10.1016/j.jobcr.2025.06.004","url":null,"abstract":"<div><div>Histological stains are specific dyes that attach to different tissues and are used in conjunction with hematoxylin and eosin stains in routine histopathology to provide useful information on tissues. With the usual stains, it becomes difficult to distinguish between the different hard tissues present in oral pathological disorders. As one of the differential stains to discriminate between the hard tissues, modified Gallego's stain can be utilized. Maxilla and mandible of a 3-day-old rabbit are collected, followed by processing and embedding of the tissues, thin paraffin sections were made &amp; stained with Modified Gallego's, and then viewed under the microscope. In the developing tooth germ, Dentin is stained green, and enamel is stained red in Modified Gallego staining. Modified Gallego staining facilitated the identification of the characteristics of hard and soft tissues during development and the changes in their behavior during maturation.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 858-863"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pharyngeal airway changes & velopharyngeal function following Le-fort I osteotomy in cleft lip and palate patients- a systematic review & meta analysis","authors":"Eldo Babu ,&nbsp;Parvathy Ghosh ,&nbsp;K. Sarika ,&nbsp;Anju James ,&nbsp;N.K. Sapna Varma ,&nbsp;V.V. Ajith","doi":"10.1016/j.jobcr.2025.06.001","DOIUrl":"10.1016/j.jobcr.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Le-Fort I osteotomy is commonly performed in cleft lip and palate patients to correct maxillary discrepancies, potentially influencing pharyngeal airway dimensions and velopharyngeal function. Thus, the review aims to evaluate the effects on pharyngeal airway and velopharyngeal function following Le-Fort I osteotomy in cleft lip and palate patients.</div></div><div><h3>Method</h3><div>This systematic review followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A comprehensive electronic search in databases of Scopus, EBSCO, PubMed, Cochrane, CINAHL, ScienceDirect and Google Scholar was performed to identify studies published from inception to August 2024 with language restricted to English. The critical appraisal using NIH quality assessment tool and data extraction processes were carried out independently by two reviewers. A meta-analysis was conducted to determine the effects of Le-Fort I on nasopharyngeal, oropharyngeal and hypopharyngeal airway depth before and after the intervention. Quality was evaluated using GRADE.</div></div><div><h3>Results</h3><div>Twelve articles were included in this review. Le-Fort I maxillary advancement significantly increases pharyngeal airway dimensions, particularly in the nasopharyngeal and oropharyngeal regions, with most studies reporting improved airway space postoperatively. However, velopharyngeal function outcomes were variable: some patients experienced transient increases in nasalance or hypernasality, while others showed no significant adverse effects. Notably, preoperative hypernasality may predict postoperative velopharyngeal insufficiency.</div></div><div><h3>Conclusion</h3><div>Le-Fort I maxillary advancement increases pharyngeal airway volume; particularly in the nasopharyngeal and oropharyngeal regions; thereby improving breathing function, especially during sleep. However, the degree of airway expansion varies depending on the extent of surgery and preoperative airway conditions. While the procedure often enhances velopharyngeal closure by improving anatomical alignment and muscle coordination, it also carries a risk of worsening velopharyngeal insufficiency if the maxilla is advanced beyond a certain limit, which differs among individuals.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 837-848"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fluoride toothpaste and mouthwash on the cytotoxicity of buccal mucosa cells in the presence of nickel-titanium archwires during comprehensive orthodontic treatment: A randomized clinical trial","authors":"Mayur Bhola ,&nbsp;Ashok Kumar Jena ,&nbsp;Madhusmita Sethy ,&nbsp;Jitendra Sharan","doi":"10.1016/j.jobcr.2025.06.007","DOIUrl":"10.1016/j.jobcr.2025.06.007","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of fluoride on the cytotoxicity of buccal mucosa cells in the presence of nickel-titanium archwires.</div></div><div><h3>Materials and methods</h3><div>Seventy-five subjects requiring comprehensive orthodontic treatment were randomly allocated to three groups. Healthy control group included normal subjects who did not receive orthodontic treatment. In the treatment control group, only stainless-steel attachments were placed without archwire. Experimental group included subjects in whom stainless-steel attachments and 0.014″ nickel-titanium archwires were used. Fluoride mouthwash and toothpaste were prescribed to all subjects. Buccal mucosa cell smear was assessed for cell viability, micronucleus scores and caspase-3 reactive cells just before (T₀) and 3-months (T₁) after the intervention.</div></div><div><h3>Results</h3><div>The buccal mucosa cell viability score was significantly lower in the experimental and treatment control groups than in the healthy control group subjects (P &lt; 0.001). Micronucleus score was significantly higher in the experimental and treatment control groups compared to the healthy control group subjects (P &lt; 0.001). The caspase-3 reactive cells and micronucleus scores were significantly more in the experimental group subjects compared to treatment control group subjects (P &lt; 0.001). There was a negative but statistically non-significant correlation between cell viability and micronucleus score among three groups of subjects.</div></div><div><h3>Conclusion</h3><div>The use of fluoride mouthwash and toothpaste in the presence of stainless-steel attachments and nickel-titanium archwire decreased the buccal cell viability by 8.51 % and increased the micronucleus score by 3.03 %. The use of fluoride toothpaste and mouthwash had a significant cytotoxicity effect on buccal mucosa cells in the presence of nickel-titanium archwire during comprehensive orthodontic treatment.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 830-836"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An umbrella review of systematic reviews/meta-analyses evaluating the antimicrobial activity of various nanoparticles on orthodontic materials & components","authors":"Vaibhav Kumar ,&nbsp;Ruchira Shreevats ,&nbsp;Aysha Syed ,&nbsp;Mansi Jaiswal ,&nbsp;Meghna Vandekar","doi":"10.1016/j.jobcr.2025.06.002","DOIUrl":"10.1016/j.jobcr.2025.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>White spot lesions (WSLs) are a prevalent issue during fixed orthodontic treatment. Orthodontic materials, such as wires, brackets, and adhesives, often create an environment that promotes microbial growth, particularly from acidogenic bacteria like Streptococcus mutans, leading to enamel demineralization. Traditional preventive measures include fluoride treatments and meticulous oral hygiene, but integrating antimicrobial nanoparticles into orthodontic materials offers a promising alternative. This umbrella review evaluates the antimicrobial efficacy of nanoparticles incorporated into orthodontic materials by assessing evidence from systematic reviews and meta-analyses. Various nanoparticles, including ZnO, Ag, and TiO₂, were studied for their potential to reduce microbial colony formation and adherence to orthodontic materials.</div></div><div><h3>Materials and method</h3><div>A literature search was conducted across PubMed, Google Scholar, The Cochrane Library, and LILACS, yielding one hundred and sixty-seven articles after removing duplicates. Following abstract and title screening, twenty-seven studies were selected for full-text review, and nine were included in the qualitative analysis. This review adheres to PRISMA guidelines and is registered with PROSPERO (CXXXXXXXXXXXX2).</div></div><div><h3>Results</h3><div>The studies indicate that incorporating AgNP into orthodontic adhesives enhances antimicrobial activity but exhibits high heterogeneity, necessitating more in vivo studies. TiO₂-coated brackets show antimicrobial properties against various pathogens. Nanoparticle-coated archwires with AgNP, N-doped TiO₂, graphene oxide, and zinc oxide reduce demineralization, are biocompatible, and reduce surface roughness, showing good to fair antimicrobial activity. Results should be interpreted cautiously, and further clinical and long-term studies are required to confirm the effectiveness of these nanoparticles in preventing white spot lesions.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 816-829"},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zebrafish caudal fin model to investigate the role of Cissus quadrangularis, bioceramics, and tendon extracellular matrix scaffolds in bone regeneration","authors":"S. Balaji Ganesh ,&nbsp;Fharreeha Fathima Anees ,&nbsp;Gurumoorthy Kaarthikeyan ,&nbsp;Taniya Mary Martin ,&nbsp;Meenakshi Sundaram Kishore Kumar ,&nbsp;M.I. Sheefaa","doi":"10.1016/j.jobcr.2025.05.009","DOIUrl":"10.1016/j.jobcr.2025.05.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Periodontal bone regeneration faces several challenges such as incomplete bone-ligament-cementum restoration, unpredictable clinical outcomes and membrane exposure risks. The zebra fish caudal fin model of regeneration could be an excellent model system for mimicking the periodontal regenerative criteria and the present study aimed to explore the potential of innovative composite scaffolds characterized by <em>C. quadrangularis,</em> carrageenan, and tendon ECM with silver hydroxyapatite and silver tricalcium phosphate for periodontal bone regeneration by using the zebrafishes as model organisms.</div></div><div><h3>Materials and methods</h3><div>Zebrafish were subjected to caudal fin amputation, followed by the application of different scaffold groups. The fabricated scaffolds were then crosslinked using glutaraldehyde vapours and stored in a desiccator for future use. The scaffolds were classified into five groups: negative control, PERIO COL- GTR (G1), <em>Cissus quadrangularis</em> extract, carrageenan, tendon extracellular matrix (TEM) (Group 2), Group 3 (contained silver hydroxyapatite + Group 2 components), Group 4 (Silver tricalcium phosphate + Group 2 components). Scaffolds characterization was done using FTIR and UV–Vis Spectroscopy. Regeneration was evaluated using microscopically and histologically.</div></div><div><h3>Results</h3><div>The physical characterization showed the scaffold interaction by spectral differentiation between the groups. Among the groups, Test group 4 demonstrated superior regeneration with enhanced collagen deposition, reduced inflammatory response, and significantly higher growth compared to control.</div></div><div><h3>Conclusion</h3><div>These findings suggested that group 4 scaffold significantly accelerates zebrafish fin regeneration, making these scaffolds promising candidates for periodontal tissue engineering and regenerative medicine applications.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 809-815"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Firm, Lyft and Relax - A versatile approach for facial rejuvenation: A case series","authors":"Marcelo Germani ,&nbsp;Ana C.N. Carnevali ,&nbsp;Isabela Guerra ,&nbsp;Dannyelle L. Rocha ,&nbsp;Danielle Dias ,&nbsp;Karina Vera Zamorano ,&nbsp;Victor R.M. Munoz-Lora","doi":"10.1016/j.jobcr.2025.05.007","DOIUrl":"10.1016/j.jobcr.2025.05.007","url":null,"abstract":"<div><div>The “Firm, Lyft, and Relax” (FL&amp;R) is a versatile approach that associates botulinum toxin (BTx), hyaluronic acid (HA), and collagen bioestimulators (CBio) treatments, suitable for patients of varying ages and diverse cosmetic concerns. This strategy considers factors such as facial static and dynamic areas, the requirement for projection or volumization, and tissue thickness and firmness. This study aims to elucidate the main concerns of the FL&amp;R technique, presenting a series of four cases and providing a guide for clinicians using combined treatment modalities for facial rejuvenation. The treatments involved the strategic use of BTx, poly-L-lactic acid (PLLA), and HA. Following the treatments, all patients experienced significant aesthetic improvements, as evaluated through 3D stereophotogrammetry. It is important to note that while this approach yields satisfactory outcomes, it should not be standardized; rather, it should be tailored to meet the unique needs of each patient.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 804-808"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}