Journal of oral biology and craniofacial research最新文献

{"title":"Whitlockite as a next-generation biomaterial for bone regeneration: A systematic review of <i>In Vivo</i> evidence for bone regeneration.","authors":"Sinduja Palati, Dhanraj Ganapathy, Saravanan Sekaran","doi":"10.1016/j.jobcr.2025.08.002","DOIUrl":"10.1016/j.jobcr.2025.08.002","url":null,"abstract":"<p><strong>Background: </strong>Whitlockite (WH), a magnesium-enriched calcium phosphate mineral, is emerging as a promising biomaterial in bone tissue engineering due to its chemical similarity to natural bone and dual role in promoting osteogenesis and regulating bone resorption. Compared to conventional materials like hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), WH offers higher solubility, superior ion release (notably Mg²⁺), and enhanced bioactivity.</p><p><strong>Objective: </strong>This systematic review evaluates the in vivo efficacy of WH-based biomaterials in bone regeneration. Key outcomes include bone volume fraction (BV/TV), bone mineral density (BMD), osteogenic marker expression, and histological bone quality.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Web of Science, Google Scholar, and Cochrane Central was conducted up to March 2025. Eligible studies assessed WH-based materials in animal bone defect models with quantifiable regenerative outcomes. Two reviewers independently performed data extraction and quality assessment using the SYRCLE Risk of Bias tool. Meta-analysis was not feasible due to significant heterogeneity across models, scaffold types, and endpoints.</p><p><strong>Results: </strong>Seventeen animal studies (rats, mice, rabbits) met inclusion criteria. WH was used in forms such as nanoparticles, granules, and scaffolds with polymers like chitosan and gelatin. WH consistently outperformed HA and β-TCP with up to a 2-6 % increase in BV/TV, BMD, and histological bone formation. Upregulation of ALP, OCN, RUNX2, and COL1 was observed. Doped WH variants and composites enhanced osteoinductive and angiogenic responses. No adverse effects were reported.</p><p><strong>Conclusion: </strong>WH demonstrates superior osteogenic and biocompatible properties over traditional calcium phosphates. Future standardized, long-term studies are needed to support clinical translation for orthopedic and dental bone regeneration.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1176-1182"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-action platelet-rich fibrin in periodontal therapy: Assessing the efficacy of injectable versus metronidazole-enhanced platelet-rich fibrin in non-surgical periodontal treatment - A clinical study.","authors":"Devadharshini Chandrasekar, Burnice Nalina Kumari Chellathurai, Jaideep Mahendra, Vijayalakshmi Rajaram","doi":"10.1016/j.jobcr.2025.07.028","DOIUrl":"10.1016/j.jobcr.2025.07.028","url":null,"abstract":"<p><strong>Background: </strong>Adjunctive therapies play a crucial role in enhancing the efficacy of non-surgical periodontal therapy (NSPT) by addressing the multifactorial nature of periodontal disease. Injectable platelet-rich fibrin (i-PRF) and metronidazole-infused PRF gel have emerged as potential biomaterials that promote periodontal regeneration and antibacterial effects, respectively.</p><p><strong>Objective: </strong>To evaluate and compare the clinical efficacy of i-PRF and metronidazole-infused PRF gel as adjuncts to NSPT in patients with periodontitis.</p><p><strong>Method: </strong>ology: A randomized controlled trial was conducted on 20 periodontal sites in patients with Stage II-III periodontitis. Sites were divided into two groups (n = 10 each), receiving either i-PRF or metronidazole-infused PRF gel following NSPT. Clinical parameters, including Oral Hygiene Index (OHI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), were assessed at baseline, 4 weeks, and 3 months. Statistical analyses included the Mann-Whitney <i>U</i> test for intergroup comparisons and the Friedman test for intragroup comparisons.</p><p><strong>Results: </strong>Both groups showed significant improvement in PPD and CAL over the study period (p < 0.001). The metronidazole-infused PRF gel group demonstrated a more pronounced reduction in GI and BOP compared to the i-PRF group (p = 0.01 and p = 0.66, respectively). Improvements in OHI were observed in both groups but were not statistically significant.</p><p><strong>Conclusion: </strong>The study highlights the potential of metronidazole-infused PRF gel as a superior adjunct to NSPT due to its enhanced antimicrobial effects and periodontal tissue healing properties. Personalized therapeutic strategies incorporating bioactive materials can optimize periodontal treatment outcomes.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1183-1189"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the role of PEKK implant material on cytotoxicity, inflammatory response, and molecular interactions with pro-inflammatory cytokines: An in-vitro and in-silico study.","authors":"Amrutha Shenoy, Subhabrata Maiti, Selvaraj Jayaram, Pradeep Kumar Yadalam, Jessy Paulraj","doi":"10.1016/j.jobcr.2025.08.004","DOIUrl":"10.1016/j.jobcr.2025.08.004","url":null,"abstract":"<p><strong>Introduction: </strong>and aim: Due to its excellent mechanical strength and biocompatibility, Polyetherketoneketone (PEKK) is emerging as a potential substitute for titanium in dental implant applications. The aim of the study was to evaluate its cytotoxicity, pro-inflammatory responses, and molecular interactions to assess its potential in implant applications.</p><p><strong>Methods: </strong>This study evaluated the cytotoxicity, pro-inflammatory cytokine responses, and molecular interactions of PEKK compared to titanium. Disc-shaped samples (10 mm × 2 mm) were fabricated for each material following ISO standards. Human periodontal fibroblast cells were cultured and treated with the samples for cytotoxicity assessment using the MTT assay, while pro-inflammatory cytokine gene expression (IL-1β, TNF-α) was analyzed via real-time PCR. Molecular docking was conducted using AutoDock to investigate PEKK's binding interactions with cytokines, and data was analyzed with one-way ANOVA and post hoc test (P < 0.05).</p><p><strong>Results: </strong>PEKK showed comparable cytocompatibility to titanium, yielding similar outcomes in cell viability (P > 0.05) or pro-inflammatory cytokine expression (P > 0.05). Molecular docking revealed strong interactions with IL-1β (-8.9 kcal/mol) and TNF-α (-7.3 kcal/mol).</p><p><strong>Conclusion: </strong>This study demonstrates that PEKK exhibits comparable cytocompatibility and pro-inflammatory responses to titanium, with a potential to modulate inflammatory pathways. Further in vivo studies are needed to confirm its clinical viability as an implant material.</p><p><strong>Clinical relevance: </strong>This study gives the clue of PEKK as an aesthetic implant biomaterial and it can be useful as an alternative to Titanium dental implant.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1218-1223"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid neoplasm of the lacrimal gland, adenocarcinoma NOS with primary squamous cell carcinoma; A rare case report.","authors":"Gopikrishnan Vijayakumar, Anjali Narwal, Mala Kamboj, Garima Rawat","doi":"10.1016/j.jobcr.2025.07.025","DOIUrl":"10.1016/j.jobcr.2025.07.025","url":null,"abstract":"<p><p>A hybrid neoplasm is the coexistence of two histologically distinct neoplasms which arise in the same topographical area resulting in a single common mass. A seventy-one-year-old female presented with a complaint of loss of vision and pain in her right eye for a period of five months. On clinical-radiological investigations, a single ovoid,non-fluctuant, firm, tender swelling was present on the right supraorbital region with mild proptosis and redness of the right eye. Magnetic resonance imaging showed a well-defined, lobulated heterogeneously enhancing lesion on the superolateral part of the right orbit suggestive of lacrimal gland neoplasm. The specimen was submitted after wide excision with orbital exenteration and ipsilateral radical neck dissection. Histopathological evaluation revealed two different morphologic patterns of infiltrating islands of epithelial cells suggestive of an adenocarcinoma and squamous carcinoma. Histopathology with additional immunohistochemical workup concluded the lesion to be a Hybrid neoplasm of the Lacrimal gland; Adenocarcinoma NOS with Primary squamous cell carcinoma. Hybrid neoplasm of the head and neck region is found to be common in salivary glands while its occurrence in the lacrimal gland is very rare in literature.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1200-1203"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical efficacy of Cention N and Tetric N-ceram in class I carious lesion in primary mandibular molars.","authors":"Mayur Mhole, Sandeep Tandon, Shriya Gupta, Harshita Gosavi, A Rizwan Ali, Mineet Kaul","doi":"10.1016/j.jobcr.2025.08.006","DOIUrl":"10.1016/j.jobcr.2025.08.006","url":null,"abstract":"<p><strong>Background: </strong>Tetric N-Ceram, recently introduced as an alternative to bulk-fill flowable and traditional non-flowable composite. Cention N, recently introduced tooth-coloured filling material for bulk placement in retentive preparations.</p><p><strong>Aim: </strong>The aim of the present study is to evaluate the performance of Tetric N Ceram and Cention N as restorative materials in Class 1 carious lesions in primary mandibular molars.</p><p><strong>Design: </strong>A prospective double-blind, split-mouth, parallel-group, randomized study was conducted on 34 patients having bilateral Class I carious lesions on mandibular primary molars. 68 teeth were divided into 2 groups: Group 1 was treated with Cention N and Group 2 with Tetric N Ceram. All restorations were clinically evaluated at Baseline - 24hrs, 3, 6 and 9 months for marginal integrity (MI), secondary caries(SC) and gross fracture(GF) using the US Public Health Service criteria (modified Ryge criteria). For post-operative sensitivity(POS), Wong Bakers faces pain rating scale was used.</p><p><strong>Results: </strong>Intragroup comparison of MI, SC and GF in Group 1 and group 2 showed non-significant difference at all-time intervals. Intergroup comparison showed non-significant difference for MI, SC, GF and POS at all-time intervals.</p><p><strong>Conclusion: </strong>Tetric N Ceram and Cention N in terms of MI, SC, GF and POS provide similar results.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1231-1237"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of reproducibility and workability of single and adjacent implant placement protocol under dynamic real time navigation systems between operators: A clinical trial.","authors":"Vamshi Nizampuram, Sahana Selvaganesh, Thiyaneswaran Nesappan","doi":"10.1016/j.jobcr.2025.08.003","DOIUrl":"10.1016/j.jobcr.2025.08.003","url":null,"abstract":"<p><strong>Introduction: </strong>Dynamic navigation (DN), a computer-assisted technique integrating CBCT data and real-time video, has emerged as a promising approach to place implants in the recent years. This study aims to evaluate the consistency and ease of use of a dynamic navigation system for implant placement by comparing the accuracy in single and adjacent implant placements and workability achieved by three different operators.</p><p><strong>Methods: </strong>This study included Forty-eight patients requiring dental implants, total of sixty implants were randomly assigned to 3 operators of varying experiences, the implants were planned and placed under DN. The accuracy of implant placement were measured in terms of mesio-distal, apico-coronal displacement and angulations using Evalunav application (<i>Navident, Claronav, Canada</i>). Secondary outcome variables are the number of errors encountered during the procedure and the time taken for the procedure by different practitioners. Kruskal Wallis Test followed by the Post hoc Mann Whitney <i>U</i> test. The level of significance was set at P < 0.05.</p><p><strong>Results: </strong>There were no significant differences in the accuracy of single implants (P > 0.05). For adjacent implants (T1), the displacement in mesiodistal direction was significantly different (P = 0.003) and also for apico-coronal position of T1-abutment group when compared to controls with a P value of 0.026. Experienced surgeons had the highest error rates as well and longest time (18.27 ± 5.62 versus 15 min).</p><p><strong>Conclusions: </strong>The operating surgeon do not determine the accuracy rather the navigation system comes with a steep learning curve that needs to be acquired prior to practicing the same.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1210-1217"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-particle coated or impregnated acrylic resins in dental applications: A systematic review of in Vivo Evidence on mechanical properties, biocompatibility and clinical performance.","authors":"Parthasarthy Natarajan, Seenivasan Madhan Kumar, Shanmuganathan Natarajan, Dr K S Sridharan, Dr S Narayana Kalkura","doi":"10.1016/j.jobcr.2025.07.018","DOIUrl":"10.1016/j.jobcr.2025.07.018","url":null,"abstract":"<p><strong>Background: </strong>Acrylic resins are extensively used in prosthodontics, orthodontics and maxillofacial prosthetics due to their ease of fabrication and cost-effectiveness. However, conventional acrylic materials are susceptible to microbial colonization, mechanical deterioration and esthetic compromise. To overcome these limitations, recent research has explored the incorporation of nanoparticles into polymethyl methacrylate (PMMA)-based resins to enhance their antimicrobial efficacy, mechanical strength, biocompatibility, and long-term durability.</p><p><strong>Methods: </strong>This systematic review was conducted according to PRISMA guidelines. An extensive literature search was performed across PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library and Embase for studies published up to January 18, 2025. Only in vivo studies conducted on humans or animals evaluating nanoparticle-coated or nanoparticle-impregnated acrylic resins were included. Standalone in vitro studies were excluded. Risk of bias was assessed using Cochrane's RoB 2.0 tool for randomized controlled trials (RCTs), ROBINS-I for non-randomized studies and the SYRCLE tool for animal studies.</p><p><strong>Results: </strong>Out of 3154 records initially identified, six studies met the eligibility criteria. The nanoparticles incorporated included silver, titanium dioxide, nanocopper, nanogold and quaternary ammonium polyethyleneimine (QPEI). All included studies reported antimicrobial activity with nanogold, nanocopper and QPEI showing sustained microbial inhibition. Mechanical outcomes varied: silver and titanium dioxide nanoparticles were associated with reduced material strength, whereas nanocopper maintained mechanical performance. Esthetic outcomes indicated that silver-based modifications caused discoloration, while nanocopper and QPEI preserved color stability.</p><p><strong>Conclusion: </strong>Nanoparticle-modified acrylic resins exhibit enhanced antimicrobial and biocompatibility profiles with certain formulations particularly those incorporating nanocopper, nanogold and QPEI showing greater clinical potential. However, mechanical durability and esthetic alterations remain challenges especially with silver and titanium-based additives. Further well-designed, long-term randomized controlled trials are warranted to validate the clinical applicability of these nano-enhanced acrylic materials.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1190-1199"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of fluoride release from different modifications of glass ionomer dental restorative material in primary teeth at different time intervals: An ex vivo study.","authors":"Vivek Mehta, Nikhil Srivastava, Saif Ali Chaudhry, Vivek Rana","doi":"10.1016/j.jobcr.2025.07.029","DOIUrl":"10.1016/j.jobcr.2025.07.029","url":null,"abstract":"<p><strong>Purpose: </strong>This ex vivo study aims to evaluate and compare the fluoride-releasing capabilities of different modifications of Glass ionomer cement, namely Giomer, Zirconomer, and Pediatric GIC (type IX) with Resin-modified Glass ionomer cement (RMGIC) in the primary dentition at first, fourteenth, and twenty-eighth days.</p><p><strong>Materials and methods: </strong>Fifty-six extracted human primary molars were allocated into four groups: Group 1, Resin-modified GIC; Group 2, Giomer; Group 3, Zirconomer; and Group 4, Pediatric GIC (type IX). The tooth samples (n = 14) were restored as per the manufacturer's instructions after making class II cavities in primary molars. Extracted tooth specimens were placed in deionized water, and the fluoride ions released were measured for 28 days. The tooth samples were evaluated for cumulative fluoride levels at the end of 24 h, 14th day, and 28th day under normal atmospheric conditions, using a fluoride ion-selective electrode (Orion STAR-A214 Ion analyzer). The data obtained was subjected to statistical analysis, and the results are discussed herein.</p><p><strong>Results: </strong>Fluoride ions releasing capability was exhibited by primary teeth restored with all the above-mentioned materials. The primary teeth restored with Zirconomer exhibited significantly higher fluoride-releasing capability among the above-compared materials, and the primary teeth restored with Giomer exhibited the least fluoride ions release on 24 h, 14th day, and 28th day, and the difference of fluoride ions releasing ability between the four groups was statistically significant at each time interval (P < 0.001).</p><p><strong>Conclusion: </strong>The primary teeth restored with Zirconomer exhibited superior fluoride-releasing ability compared to other restorative materials. Therefore, Zirconomer can be a promising restorative material for primary teeth due to its enhanced anti-caries effect.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1224-1230"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Samarium-doped hydroxyapatite: An effective approach for enhancing biomineralization in dental caries management.","authors":"C P Harini, Radha Gosala, Ramya Ramadoss","doi":"10.1016/j.jobcr.2025.07.026","DOIUrl":"10.1016/j.jobcr.2025.07.026","url":null,"abstract":"<p><strong>Background: </strong>Dental caries is a widespread non-communicable disease caused by interactions among acidogenic bacteria, fermentable carbohydrates, and host factors, leading to tooth demineralization. In dentin caries, this process exposes dentinal tubules, causing sensitivity and structural degradation. Despite available agents, effective dentin remineralization remains a challenge. Recent studies highlight samarium-doped hydroxyapatite (Sm-HAp) as a potential biomaterial for promoting remineralization.</p><p><strong>Aim: </strong>To synthesize and characterize the samarium doped hydroxyapatite (Sm-HAp) as a potential agent in dentin remineralization.</p><p><strong>Materials and methods: </strong>Sm-HAp was synthesized via wet-chemical precipitation. Characterization was performed using SEM for morphology, FTIR for functional groups, and XRD for crystalline features. MTT assay evaluated for biocompatibility and <i>in vitro</i> mineralization analyzed on human tooth samples.</p><p><strong>Results: </strong>SEM showed flake-like, and needle-shaped crystals. XRD indicated the formation Sm doped hydroxyapatite without any additional phase, which further confirmed by FTIR. MTT assay showed >85 % cell viability, confirming high biocompatibility and also an efficient dentine mineralization was observed with Sm-HAp treatment.</p><p><strong>Conclusion: </strong>Sm-HAp demonstrates favorable structural, chemical, and biological properties, supporting its potential as a dentin remineralizing agent in dental caries management.</p>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"1204-1209"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin mitigates the histopathological and molecular changes in sublingual glands in diabetic male rats","authors":"Maha El Shahawy","doi":"10.1016/j.jobcr.2025.09.023","DOIUrl":"10.1016/j.jobcr.2025.09.023","url":null,"abstract":"<div><h3>Objective</h3><div>demonstrate the possible palliative role of curcumin in the prospective molecular and histological alterations in the sublingual glands of diabetic male rats.</div></div><div><h3>Methods</h3><div>Twenty-one male adult rats were used and randomly assigned into three groups (n = 7). The control group consisted of rats administered a single IP injection of saline. The diabetic group included rats receiving one dose of alloxan (140 mg/kg). The nanocurcumin-treated rat group (NC group) contained diabetic rats administered 200 mg/kg nanocurcumin. After 42 days, the salivary glands were dissected and assessed for Masson trichrome, Hematoxylin and eosin (H&amp;E) staining, expression of c-kit and β-catenin, and histomorphometric analysis.</div></div><div><h3>Results</h3><div>The sublingual glands of diabetic rats revealed altered histology. In addition, the salivary tissues depicted an apparent change in β-catenin, and c-kit expression. The NC group resumed the normal sublingual gland architecture and c-kit and β-catenin expression.</div></div><div><h3>Conclusion</h3><div>Curcumin treatment rescued the histological and molecular changes in the sublingual glands of the diabetic rats. The ameliorating effect of curcumin on sublingual tissues of diabetic rats may be due to resuming of expression of β-catenin suggesting restoration of Wnt/β-catenin signaling in the glandular tissues which can maintain the c-kit + glandular stem/progenitor cells.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"Pages 1641-1647"},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}