Journal of oral biology and craniofacial research最新文献

{"title":"Enhancing angiogenesis through secretomes: Insights from scratch wound assay","authors":"Madhura Shekatkar ,&nbsp;Supriya Kheur ,&nbsp;Shantanu Deshpande ,&nbsp;Swapnali Sakhare ,&nbsp;Avinash Sanap ,&nbsp;Avinash Kharat ,&nbsp;Ramesh Bhonde","doi":"10.1016/j.jobcr.2025.05.008","DOIUrl":"10.1016/j.jobcr.2025.05.008","url":null,"abstract":"<div><h3>Background</h3><div>This study uses a scratch wound healing assay to investigate the angiogenic potential of secretomes derived from dental mesenchymal stem cells (DMSCs). Angiogenesis, defined as the process of generating new blood vessels, plays a pivotal role in the mechanisms of tissue regeneration and repair.</div></div><div><h3>Methodology</h3><div>We cultured DMSCs under standard conditions, collected the secretomes, and applied them to human endothelial cells cultured in a scratch-assay setup. Endothelial cell migration into the scratch area was observed and quantified over a 48-h period. Results were compared to controls treated with a standard growth medium.</div></div><div><h3>Results</h3><div>Preliminary findings indicate that DMSC-derived secretomes of dental pulp significantly enhance the migration of endothelial cells compared to controls, suggesting a strong angiogenic potential.</div></div><div><h3>Conclusion</h3><div>These findings show that DMSC secretomes from dental pulp can help with angiogenesis. This could have big effects on the development of new treatments for tissue repair and regeneration. This study provides valuable insights into the paracrine mechanisms through which DMSCs may contribute to angiogenesis, highlighting their potential in regenerative medicine applications.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 789-798"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of the tmd-e tracker for diagnosing temporomandibular disorders: a reliability and accuracy assessment","authors":"Ramya Srinivasan,&nbsp;Shilpi Gupta,&nbsp;Naveen Gopi Chander,&nbsp;Anitha Kuttae Viswanathan","doi":"10.1016/j.jobcr.2025.05.006","DOIUrl":"10.1016/j.jobcr.2025.05.006","url":null,"abstract":"<div><h3>Aim</h3><div>Temporomandibular disorders (TMDs) are musculoskeletal conditions affecting the temporomandibular joint (TMJ), often leading to pain, restricted movement, and joint sounds. Traditional diagnostic methods rely on subjective assessments and imaging, which have limitations in terms of accessibility and cost. The TMD-E Tracker is a novel, non-invasive device designed to quantify TMJ vibrations and classify TMD severity in real time. This study aimed to assess the diagnostic accuracy, reliability, and feasibility of the TMD-E Tracker in detecting TMDs and to compare its findings with standard clinical diagnostic methods.</div></div><div><h3>Materials and methods</h3><div>A total of 24 participants (12 TMD patients, 12 healthy individuals) were evaluated using the TMD-E Tracker. The device recorded peak vibrational frequency and timing of peak occurrence, which were statistically compared with standard clinical diagnostic measures. Intra- and inter-examiner reliability were assessed using the Intraclass Correlation Coefficient (ICC). Statistical analysis was performed using independent t-tests with p &lt; 0.05 considered significant.</div></div><div><h3>Results</h3><div>TMD patients exhibited a significantly higher peak frequency (248 ± 28 Hz) and delayed peak occurrence timing (1.65 ± 0.38 s) compared to healthy individuals (108 ± 22 Hz, 0.95 ± 0.21 s, p &lt; 0.05). The device demonstrated excellent intra-examiner reliability (ICC = 0.91) and inter-examiner reliability (ICC = 0.89). The sensitivity (89.5 %) and specificity (92.3 %) further confirmed the high diagnostic accuracy of the TMD-E Tracker.</div></div><div><h3>Conclusion</h3><div>The TMD-E Tracker is a reliable, objective, and clinically feasible diagnostic tool for TMD assessment. Its real-time vibrational analysis offers a promising alternative to conventional diagnostic methods, though further large-scale validation is warranted.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 799-803"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of salivary Insulin-like Growth Factor-1 (IGF-1) in the regulation of biomechanical process following mandibular advancement with a twin block appliance-a prospective observational study","authors":"Tulika Tripathi ,&nbsp;Navneet Singh ,&nbsp;Veena GV ,&nbsp;Bhawna Mahajan ,&nbsp;Priyank Rai","doi":"10.1016/j.jobcr.2025.05.004","DOIUrl":"10.1016/j.jobcr.2025.05.004","url":null,"abstract":"<div><h3>Background</h3><div>An increased expression of Insulin-like growth factor-1 (IGF-1) in the condyle following mandibular advancement has been observed in animal studies. However, the exact role of IGF-1 in the regulation of biomechanical process of Twin block in humans is still unclear. Hence, the aim of the present study was to investigate the role of salivary IGF-1 following mandibular advancement with Twin block appliance in subjects having skeletal Class II malocclusion.</div></div><div><h3>Materials and methods</h3><div>This prospective observational study enrolled 49 subjects with skeletal Class II malocclusion who were administered Twin block. Salivary samples were collected at: pre-treatment (T0), one week (T1), 6–10 weeks (T2), 8–10 months (T3) and post-treatment (T4). Subjects who were non-compliant were taken as the non-compliant group (NCG; n = 10), (Twin block group, TBG; n = 39). Lateral cephalograms were obtained at T0, T3 and T4 for TBG and at T0, T4 for NCG to evaluate the various skeletal and dentoalveolar effects. Friedman test, Wilcoxon signed test and Mann-Whitney <em>U</em> test were performed for statistical comparison of salivary IGF-1 levels and cephalometric parameters within and between the two groups.</div></div><div><h3>Results</h3><div>In TBG, salivary IGF-1 levels significantly increased at one week (p = 0.000), followed by a plateau, while NCG showed no significant changes. Cephalometric analysis revealed significant improvements in mandibular length and other parameters in TBG compared to NCG.</div></div><div><h3>Conclusions</h3><div>The study demonstrates a significant increase in salivary IGF-1 levels following mandibular advancement, suggesting its regulatory role in biomechanical process of the Twin block appliance.</div></div><div><h3>Clinical relevance</h3><div>The findings of this study hold significant future potential in the field of dentofacial orthopaedics. The development of a panel of salivary biomarkers could offer a more comprehensive understanding of the biological processes involved in mandibular advancement and growth, leading to more precise and customized treatment plans.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 783-788"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of stress levels in mothers of children with autism spectrum disorder using video self-modeling during children's dental procedure","authors":"Kripa Dutta,&nbsp;Kavita Rai,&nbsp;Amarshree A. Shetty,&nbsp;H. Ananthu,&nbsp;Manju Raman Nair","doi":"10.1016/j.jobcr.2025.05.005","DOIUrl":"10.1016/j.jobcr.2025.05.005","url":null,"abstract":"<div><h3>Background</h3><div>Autism Spectrum Disorder (ASD) is a neurodevelopmental condition affecting social interaction, communication, and behavior. Mothers of children with ASD often experience chronic stress, leading to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and low cortisol levels. Salivary cortisol, a non-invasive biomarker, reflects physiological stress responses. Effective behavior guidance in pediatric dentistry can improve the dental experience for children with ASD and reduce maternal stress. Video self-modeling (VSM) is a promising intervention to enhance cooperation in children with ASD during dental procedures.</div></div><div><h3>Aim</h3><div>This study aimed to estimate the salivary cortisol levels in the mothers of children with ASD following the application of VSM as a behavior guidance technique for their children during dental procedures.</div></div><div><h3>Materials and methods</h3><div>Twenty-two mothers of children with ASD (aged 6–12 years) participated. Salivary cortisol samples were collected at baseline and two weeks post-intervention. Cortisol levels were measured using enzyme-linked immunosorbent assay (ELISA), and a paired <em>t</em>-test compared pre- and post-intervention levels.</div></div><div><h3>Results</h3><div>Pre-intervention cortisol levels ranged from 13.35 ng/ml to 63.35 ng/ml (mean 33.2 ± 15.8 ng/ml). Post-intervention levels increased, ranging from 13.35 ng/ml to 55.52 ng/ml and difference was statistically significant (mean 44.2 ± 10.1 ng/ml; t = −2.53, p = 0.019).</div></div><div><h3>Conclusion</h3><div>This study highlights the bidirectional relationship between child behavior and maternal stress. VSM improved cooperation in children with ASD during dental procedures and positively impacted maternal stress, as shown by increased salivary cortisol, thus emphasizing the need for behavior interventions benefiting both children and their families.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 779-782"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical coronoid process displacement in ZMC Trauma: Technical considerations and management algorithm – A technical note","authors":"Jishnu Mohan,&nbsp;Virendra Singh,&nbsp;Ankita Dahiya,&nbsp;Rajesh Chauhan,&nbsp;Rashmi Bawane","doi":"10.1016/j.jobcr.2025.05.003","DOIUrl":"10.1016/j.jobcr.2025.05.003","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 775-778"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute oral toxicity and mucosal irritation of a mouthwash containing chlorhexidine and chlorine dioxide in animal models","authors":"Thao Thi Phuong Tran ,&nbsp;Lam Nguyen Le ,&nbsp;Thanh Van Tran ,&nbsp;Thuy Anh Vu Pham","doi":"10.1016/j.jobcr.2025.04.013","DOIUrl":"10.1016/j.jobcr.2025.04.013","url":null,"abstract":"<div><h3>Background</h3><div>Halitosis is primarily caused by bacterial activity in the oral cavity. Chlorhexidine (CHX) is a widely used antimicrobial mouthwash but has notable side effects. Chlorine dioxide (ClO₂) is a potent oxidizer that may reduce the required CHX concentration while preserving efficacy. This study evaluates the acute systemic toxicity and local mucosal irritation of a CHX-ClO₂ combination in animals, to determine its safety for potential human use.</div></div><div><h3>Material and method</h3><div>Mice were administered a single oral dose of a mouthwash containing 0.5 % CHX and 2.5 % ClO₂. Clinical signs, mortality, and body weight were monitored over 14 days. In a separate test, rabbit buccal mucosa was exposed to the same mouthwash daily for 14 days. Macroscopic and microscopic irritation scores were recorded according to ISO 10993–23:2021.</div></div><div><h3>Result</h3><div>No mortality or significant clinical toxicity was observed in mice. Only transient ocular irritation occurred in 30 % of the test group.</div></div><div><h3>Conclusion</h3><div>The combination of 0.5 % CHX and 2.5 % ClO₂ appears safe in mice and causes negligible irritation in rabbit oral mucosa.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 770-774"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of scalpel and diode laser techniques in gingival depigmentation: A split-mouth randomized controlled trial with RGB photographic Quantification","authors":"Devadharshini Chandrasekar,&nbsp;Pavithra Gopalakrishnan,&nbsp;Vijayalakshmi Rajaram,&nbsp;Burnice Nalina Kumari Chellathurai,&nbsp;Anitha Logaranjani,&nbsp;Jaideep Mahendra,&nbsp;Nikita Ravi","doi":"10.1016/j.jobcr.2025.05.001","DOIUrl":"10.1016/j.jobcr.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Gingival aesthetics, integral to a smile's attractiveness, can be significantly impacted by pigmentation. Melanin, produced by melanocytes, contributes to this pigmentation, which can be addressed through various depigmentation techniques. This study aims to compare the efficacy of conventional scalpel and diode laser methods for gingival depigmentation using RGB photographic analysis.</div></div><div><h3>Materials and methods</h3><div>This split-mouth, randomized controlled trial involved five participants with bilateral maxillary gingival hyperpigmentation. One sextant per participant was treated with a scalpel (Group 1), and the contralateral sextant was treated with a diode laser (940 nm) (Group 2). Parameters assessed included intraoperative bleeding, postoperative pain (VAS), wound healing (Wound Healing Index), and pigmentation (Dummett Oral Pigmentation Index). RGB photographic analysis was used to quantify colour changes.</div></div><div><h3>Results</h3><div>No significant difference was observed in intraoperative bleeding between the groups (p = 0.31). Postoperative pain was significantly lower in Group 2 on Day 1 (p = 0.01), though this difference was not significant by Day 7 (p = 0.25). Wound healing scores were comparable at 7 days and 6 months but were significantly better in Group 2 at 12 months (p = 0.01). Pigmentation reduction was significantly greater in Group 2 at 6 months (p = 0.01), but the difference was not significant at 12 months (p = 1.00). RGB analysis revealed that Group 2 achieved superior control of pigmentation, with significant differences in red, green, and blue values at multiple time points (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Diode laser treatment (Group 2) demonstrated superior aesthetic outcomes and reduced postoperative pain compared to the scalpel technique (Group 1), along with more effective long-term pigmentation control. RGB analysis provided valuable objective data supporting these findings.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 763-769"},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the cytotoxicity, apoptotic effects, and remineralization potential of recent bioceramic-based root canal sealers","authors":"Manar M. Galal ,&nbsp;Amira Galal Ismail ,&nbsp;Yousra Nashaat ,&nbsp;Tamer M. Hamdy","doi":"10.1016/j.jobcr.2025.05.002","DOIUrl":"10.1016/j.jobcr.2025.05.002","url":null,"abstract":"<div><h3>Background</h3><div>This study is aimed at evaluating the cytotoxicity, apoptosis/necrosis, and calcium ion release of ADseal (a resin-based sealer) and two recently introduced bioceramic-based root canal sealers, which are VDW.1 seal bioceramic and Fill Root ST.</div></div><div><h3>Methods</h3><div>The cellular responses were studied in human periodontal ligament stem cells (hPDLSCs). Four root canal sealer extracts concentrations (100 %, 50 %, 25 %, and 12.5 %) were assessed for cell viability using the cell viability MTT essay and after 24 h, 48 h, and 7 days for all concentrations. To determine the effect of materials on apoptosis and necrosis, flow cytometry analysis was used. Calcium ion release was evaluated after 14 days of storage in distilled water using optical emission spectroscopy (ICP-OES). A two-way ANOVA was used for the statistical analysis of the acquired results.</div></div><div><h3>Results</h3><div>Fill Root ST and VDW.1 seal bioceramic showed the highest amount of cell viability compared to ADseal sealer. Moreover, Fill Root ST, followed by VDW.1 seal bioceramic, demonstrated decreased cell apoptosis and necrosis. Moreover, VDW.1 seal bioceramic showed the highest calcium ion release, followed by Fill Root ST. ADseal sealers showed the lowest calcium ion release compared to bioceramic-based root canal sealers.</div></div><div><h3>Conclusions</h3><div>Based on the results of this study, in terms of cytotoxicity, apoptosis/necrosis, and remineralization ability, bioceramic-based root canal sealers were more biocompatible than ADseal resin-based sealers.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 757-762"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dentin thickness preservation and the efficiency of instrumentation between traditional and guided endodontic access in mandibular central incisors","authors":"Pooja R. Kesharani ,&nbsp;Shalini D. Aggarwal ,&nbsp;Nishtha K. Patel ,&nbsp;Jhanvi Patel ,&nbsp;Ankita Bansal ,&nbsp;Naman Patel","doi":"10.1016/j.jobcr.2025.04.011","DOIUrl":"10.1016/j.jobcr.2025.04.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Tooth substance loss during endodontic treatment is a major concern, especially in mandibular incisors due to their minimal tooth volume. Template-guided access cavities help preserve dentin and improve instrument centering. This in vitro study compares remaining dentin thickness (RDT) and centering ability of rotary instruments using both conventional and template-guided approaches in mandibular incisors.</div></div><div><h3>Objective</h3><div>Comparative in vitro CBCT study on remaining dentin thickness and centering ability of rotary instrumentation in mandibular incisors using conventional vs. template-guided access cavity preparation.</div></div><div><h3>Methodology</h3><div>Pre-treatment CBCT scans were taken of 80 mandibular incisors, to evaluate the existing dentin thickness and these were then divided into 2 groups of 40 teeth each. Conventional endodontic access cavities were made in Group −1, and guided access openings were done in Group – 2. Post-operative CBCT scans were taken to measure the RDT canal centering ability of each approach.</div><div>The data was examined using a one-way analysis of variance, followed by Tukey's post-hoc test for multiple pairwise comparisons, with a significance level set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>The mean RDT was significantly higher in the group where a template-guided access opening was done. The statistical difference for RDT amongst both the experimental groups was highly significant at the Cemento-Enamel Junction and 9 mm from the root apex. Statistically significant results were obtained 6 mm level and insignificant result was obtained at 3 mm level from root apex. No significant differences in the centering ability ratio were observed between the Traditional Endodontic Cavity (TEC) and Guided Endodontic Cavity (GEC) at any level.</div></div><div><h3>Conclusion</h3><div>Pericervical dentin was preserved more in guided access cavity preparation. The design of the access cavity preparation did not impact the centering ratio of the instruments used for shaping the root canals.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 749-756"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between cephalometric analyses in diagnosing the dento-skeletal characteristics of malocclusion","authors":"J. Monisha,&nbsp;Ulaganathan Sangeetha,&nbsp;Bhaskar Nivethitha,&nbsp;Balasubramanian Madhan","doi":"10.1016/j.jobcr.2025.04.012","DOIUrl":"10.1016/j.jobcr.2025.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Conflicting results from different cephalometric analyses is a common problem with broader implications but has not received due attention. This study evaluated the agreement between common cephalometric analyses in diagnosing the essential dento-skeletal characteristics of malocclusion.</div></div><div><h3>Material and methods</h3><div>A total of 125 lateral cephalograms were analyzed digitally using Downs, Steiner, Wits, Tweed, Bjork, Ricketts, and McNamara analysis. The diagnosis of sagittal jaw relation (Class 1/2/3), maxillary and mandibular positions (Orthognathic/Prognathic/Retrognathic), growth pattern (Normodivergent/Hypodivergent/Hyperdivergent), and upper and lower incisors positions (Normal/Proclined/Retroclined) were established based on each analysis. The extent of agreement between the analyses was assessed using Kappa statistics.</div></div><div><h3>Results</h3><div>The overall agreement between analyses was moderate for sagittal jaw relationship [k = 0.41 (0.37-0.45)], fair for growth pattern [k = 0.24 (0.20-0.27)], mandibular position [k = 0.25, (0.20-0.30)], upper incisor (k = 0.38, CI = 0.32-0.44) and lower incisor [k = 0.21 (0.17-0.25)] positions, and only slight for maxillary position [k = 0.18 (0.13-0.23)]. For pairwise comparisons of analyses, the agreement was moderate to substantial for the sagittal jaw relationship (except for comparisons involving McNamara analysis) and slight to moderate for other variables. Also, the diagnosis of normal dentofacial relationships (Class 1 and normodivergent skeletal pattern, orthognathic jaw positions, and normal incisor positions) was less consistent than those of deviant subgroups.</div></div><div><h3>Conclusions</h3><div>The agreement between the cephalometric analyses evaluated was moderate for sagittal jaw relation and only fair for most other dento-skeletal characteristics. McNamara's analysis showed less agreement with others. These highlight the need for a more cautious and scientific approach to Cephalometrics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 744-748"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}