含生物活性添加剂的增强玻璃离聚体骨水泥用于兔牙髓的胶原合成和炎症

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-07-16 DOI:10.1016/j.jobcr.2025.07.007

Nattapon Rotpenpian , Peerapon Sornying , Sareepah Manmoo , Krittee Dejyong

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引用次数: 0

摘要

目的通过添加15%壳聚糖、5%牛血清白蛋白（BSA）、0.05%磷酸三钙（TCP）和1 μg翻译控制肿瘤蛋白（TCTP），对常规玻璃离子水门合剂（GIC）进行强化。本研究评估了其在兔前牙的粘附性能、生物相容性和促进牙髓组织愈合的能力。材料与方法采用家兔模型对增强型gic进行物理黏附及对牙髓组织的生物学效应测试。牙体预备及材料放置后观察21 d。组织学评价集中在牙髓组织的炎症、毒性和胶原合成。结果增强GIC的粘附性能与常规GIC相当。组织学分析显示两组牙髓组织均无明显炎症或毒性反应。增强gic组表现出优越的生物相容性，表现为髓组织内淋巴细胞浸润增加和胶原合成增强，表明其促进组织再生的潜力。结论增强型GIC配方在牙髓修复中具有良好的应用前景，在牙髓组织愈合和胶原形成方面具有优势，同时保持与常规GIC相当的粘连性。本研究强调了增强型gic在牙科修复手术中的应用潜力，特别是在需要牙髓再生的病例中。

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Enhanced glass ionomer cement with bioactive additives for collagen synthesis and inflammation in pulp-rabbit teeth

Objective

This study aimed to enhance conventional glass ionomer cement (GIC) by incorporating 15 % chitosan, 5 % bovine serum albumin (BSA), 0.05 % tricalcium phosphate (TCP), and 1 μg translationally controlled tumor protein (TCTP), resulting in an enhanced-GIC formulation. The study evaluated its adhesion properties, biocompatibility, and ability to promote pulp tissue healing in rabbit anterior teeth.

Materials and methods

The enhanced-GIC was tested in a rabbit model to assess its physical adhesion and biological effects on pulp tissue. Following cavity preparation and material placement, the teeth were observed for 21 days. Histological evaluations focused on inflammation, toxicity, and collagen synthesis in pulp tissue.

Result

The enhanced-GIC showed comparable adhesion properties to conventional GIC. Histological analysis revealed no significant inflammation or toxicity in the pulp tissue of either group. The enhanced-GIC group exhibited superior biocompatibility, demonstrated by increased lymphocyte infiltration and enhanced collagen synthesis within the pulp tissue, suggesting its potential for promoting tissue regeneration.

Conclusion

The enhanced-GIC formulation shows promise as a sublining material in restorative dentistry, offering benefits in pulp tissue healing and collagen formation, while maintaining adhesion comparable to conventional GIC. This study highlights enhanced-GIC's potential for use in dental restorative procedures, particularly for cases requiring pulp regeneration.

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.