Journal of oral biology and craniofacial research最新文献

{"title":"Worst pattern of invasion in oral squamous cell carcinoma: An independent prognostic indicator","authors":"Manahil Rahat ,&nbsp;Umair Aslam Shahzad ,&nbsp;Nighat Ara ,&nbsp;Hafeez Ud din ,&nbsp;Bushra Parveen ,&nbsp;Naveed Khan ,&nbsp;Saadia Munir ,&nbsp;Hassan Mumtaz","doi":"10.1016/j.jobcr.2024.12.008","DOIUrl":"10.1016/j.jobcr.2024.12.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral squamous cell carcinoma is a malignancy that is biologically aggressive.</div></div><div><h3>Objective</h3><div>To investigate the correlation between various histopathological factors and the worst patterns of invasion at the tumor-host interface, which were classified as cohesive (1–3) and non-cohesive (4&amp;5).</div></div><div><h3>Methods</h3><div>Neck dissections were performed on 81 cases of oral squamous cell carcinoma those had been diagnosed. The selection was limited to paraffin-embedded blocks that contained sections from the tumor. Tumor staging, nodal staging and other factors such as lymphovascular invasion, perineural invasion, extra nodal extension, depth of invasion, margin status and tumor differentiation grades were documented.</div></div><div><h3>Results</h3><div>The findings indicate a higher frequency of non-cohesive worst invasion patterns in numerous anatomical sites. A prediction accuracy of 69.1 % was obtained from the logistic regression analysis, suggesting that the predictive performance has also improved. The chi square test results demonstrated a statistically significant correlation between the variable of interest and extranodal extension showing a p value of 0.008 while lymph node status also showed significant with a p value of 0.000. Another factor that depicted a significance with worst pattern of invasion was tumor margin status having a p value of 0.046. Lymphovascular invasion and the worst pattern of invasion also exhibited a statistically significant correlation, with a p-value of 0.013.</div></div><div><h3>Conclusion</h3><div>The results of this investigation indicate that aggressive tumor biology is associated with non-cohesive worst pattern of invasion. Non-cohesive worst pattern of invasion is associated with moderate differentiation grade, lymphovascular invasion, perineural invasion, extranodal extension, closed or involved tumor margins and nodal metastases.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 638-644"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Polydeoxyribonucleic Acid (PDRN) in periodontal regeneration: A systematic review of clinical outcomes","authors":"Ranjith Mari ,&nbsp;Jaiganesh Ramamurthy ,&nbsp;K. Rudhra ,&nbsp;Nitya Krishnaswamy","doi":"10.1016/j.jobcr.2025.03.021","DOIUrl":"10.1016/j.jobcr.2025.03.021","url":null,"abstract":"<div><h3>Background</h3><div>Periodontal disease is a major dental health concern due to its impact on the supporting structures of teeth, including the alveolar bone and periodontal ligament. Polydeoxyribonucleic Acid (PDRN) has shown promise in promoting tissue regeneration through anti-inflammatory effects and angiogenesis, crucial for periodontal healing.</div></div><div><h3>Objective</h3><div>To evaluate the clinical effectiveness of Polydeoxyribonucleic Acid (PDRN) in periodontal regeneration through a systematic analysis of available studies.</div></div><div><h3>Methods</h3><div>This review followed PRISMA guidelines and included randomized controlled trials (RCTs), cohort, and case-control studies assessing PDRN's effects on periodontal regeneration. A comprehensive search in PubMed, Scopus, Web of Science, and Embase was conducted using keywords related to PDRN and periodontal regeneration. Primary outcomes included clinical attachment level (CAL) gain, probing depth reduction, and bone fill. Two reviewers independently assessed study eligibility and extracted data on PDRN application methods, dosages, and observed outcomes.</div></div><div><h3>Results</h3><div>Among the four studies that met the inclusion criteria, significant improvements in CAL, bone fill, and probing depth reduction were consistently observed in PDRN-treated sites compared to controls. Animal studies also demonstrated enhanced bone quality, reduced inflammation, and a conducive environment for cell proliferation. Clinical trials indicated that PDRN, as an adjunct to conventional therapy, produced more favorable outcomes in periodontal healing. PDRN's activation of adenosine A2A receptors and VEGF expression promoted angiogenesis and modulated inflammatory responses, aiding regeneration.</div></div><div><h3>Conclusion</h3><div>PDRN appears to offer substantial benefits in periodontal regeneration by enhancing bone and tissue healing and reducing inflammatory responses. While promising, further clinical trials are necessary to determine optimal dosing and long-term effectiveness. This systematic review provides evidence supporting PDRN as a potential adjunctive treatment for periodontitis, with implications for enhancing clinical outcomes in periodontal therapy.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 624-630"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative fractal analysis of mandibular condyles in temporomandibular disorder and non-temporomandibular disorder patients using cone-beam computed tomography","authors":"Kavali Laxmi Swetha,&nbsp;Sairam Vankadara,&nbsp;Nerrugatti Shiny chelshiya,&nbsp;Bhaandhavi Akula","doi":"10.1016/j.jobcr.2025.03.017","DOIUrl":"10.1016/j.jobcr.2025.03.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Temporomandibular joint (TMJ) anatomy and microstructure is complex. Multifactorial disorders of the TMJ may affect the musculoskeletal and osseous structures of the joint. It is highly beneficial to detect these changes early in the development of temporomandibular disorders (TMDs) in order to prevent their progression. There are several pathological conditions that can affect the trabecular bone of the mandibular condyle in the TMJ. In order to analyse these changes, it is possible to measure them through the use of fractal dimensional analysis, as they are natural fractals.</div></div><div><h3>Aim &amp; objective</h3><div>Fractal analysis was used in this study to examine the trabecular pattern of the mandibular condyle, with the objective of assessing fractal dimension changes in mandibular condyles for TMD diagnosis.</div></div><div><h3>Methods</h3><div>The 120 subjects are divided into two groups, a Control group (non-TMD's-60 each) and a Study group (TMD's-60 each). The study includes participants diagnosed with TMD's according to RDC/TMD Axis -I &amp; Axis-II (Research diagnostic criteria,2014). Cone bean computed Tomography (CBCT) images are captured and converted into JPEG images. A fractal dimensional analysis is performed on the condylar portion of the trabecular bone. With Image J software version 1.51 program (National Institutes of Health, Bethesda, MD @; <span><span>https://imagej.nih.gov/ij/download.html</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>The present study found that subjects with TMD had significantly lower fractal values than controls (p &lt; 0.001 on right side and left side p &lt; 0.021).</div></div><div><h3>Conclusion</h3><div>The study group had lower fractal values than the control group. This study in additional hypothesized fractal values for each type of TMD. The use of CBCT can enhance the diagnosis of TMD.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 631-637"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of chronic periodontitis and type 2 diabetes mellitus on resistin levels of gingival crevicular fluid- a systematic review and meta-analysis","authors":"Dax Abraham ,&nbsp;Alpa Gupta ,&nbsp;Arun Kumar Duraisamy ,&nbsp;Mrinalini Mrinalini","doi":"10.1016/j.jobcr.2025.03.022","DOIUrl":"10.1016/j.jobcr.2025.03.022","url":null,"abstract":"<div><h3>Aim</h3><div>Chronic periodontitis (CP), a prevalent inflammatory dental disease, has been linked to systemic conditions like Type 2 Diabetes Mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate resistin levels in the Gingival Crevicular Fluid (GCF) of CP individuals with T2DM. The objective was to determine if resistin could be a potential biomarker for periodontal disease in T2DM individuals.</div></div><div><h3>Methods</h3><div>The review included data from seventeen clinical studies that investigated resistin levels in GCF of individuals diagnosed with CP and T2DM. Data were sourced from PubMed, Scopus, and EBSCOhost, selected for their extensive coverage of medical and dental research, ensuring thorough retrieval of relevant studies. From the initial seventeen studies, five complied with the strict inclusion criteria for meta-analysis.</div></div><div><h3>Results</h3><div>Using a comprehensive meta-analysis, the significance of GCF Resistin levels in individuals with CP and T2DM relative to the healthy groups was examined. In addition, a meta-analysis was carried out to look into the relationship between periodontal probing depth (PPD) and CP and T2DM. The results indicated that individuals with T2DM and CP had significantly higher GCF resistin levels than the other groups. Furthermore, the PPD in T2DM with CP was significantly greater than in the other groups.</div></div><div><h3>Conclusion</h3><div>The present review highlights the potential role of resistin as a biomarker to diagnose individuals with chronic periodontitis and T2DM.</div></div><div><h3>Clinical significance</h3><div>The significantly elevated levels of resistin suggest that resistin could serve as a potential biomarker for T2DM in individuals with CP. This could lead to improved methods of early diagnosis and treatment, which could enhance individual outcomes and quality of life.</div></div><div><h3>Prospero registration</h3><div>The registration number CRD42023467186.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 612-623"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cariogenic potential and pharmacokinetics of Licorice and Xylitol infused chewing gum","authors":"Jencia Amaly ,&nbsp;Ramya Ramadoss ,&nbsp;K. Nitya ,&nbsp;Sundar Sandhya ,&nbsp;Suganya Panneer Selvam ,&nbsp;K. Hema Shree ,&nbsp;G. Radha","doi":"10.1016/j.jobcr.2025.03.012","DOIUrl":"10.1016/j.jobcr.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Dental caries remains a global health challenge despite advancements in prevention. Traditional approaches focus on mechanical plaque removal and fluoride use, but innovative, non-invasive solutions are increasingly sought. Chewing gum, as a delivery system for bioactive ingredients, offers a convenient method for improving oral health. Xylitol, licorice, and lemon balm, known for their anti-cariogenic and antimicrobial properties, were incorporated into a novel chewing gum to evaluate its potential in preventing caries.</div></div><div><h3>Methods</h3><div>The chewing gum was formulated using beeswax, glycerin monostearate, xanthan gum, xylitol, lemon balm, and licorice. Physicochemical properties were assessed through Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Rheological properties, including elasticity and viscosity, were analyzed to ensure optimal texture. Antimicrobial activity was evaluated using the Minimum Inhibitory Concentration (MIC) method against key cariogenic bacteria, while flavor dynamics and in-silico docking and ADMET analysis provided additional insights.</div></div><div><h3>Results</h3><div>FTIR and XRD confirmed the successful integration of bioactive components and an amorphous matrix structure, promoting controlled release and stability. Antimicrobial assays showed the gum's effectiveness against Streptococcus mutans (MIC 0.20 mg/mL), with varying efficacy against other pathogens. Rheological analysis revealed xanthan gum as a key contributor to elasticity and viscosity, ensuring chewability and stability. Flavor release dynamics highlighted prolonged taste perception, with licorice providing sustained intensity. In-silico analysis supported the bioavailability and favorable pharmacokinetics of the ingredients.</div></div><div><h3>Conclusion</h3><div>This novel chewing gum demonstrates significant potential as an anti-cariogenic product with a balanced formulation of functional, structural, and sensory properties. Future research, including clinical trials and consumer testing, will be essential to optimize its effectiveness and marketability, addressing the demand for user-friendly oral health solutions.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 605-611"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oral health status and salivary profile of rheumatoid arthritis disease subjects and healthy subjects and prediction of caries risk using cariogram- A cross-sectional analytical study","authors":"Ananya Jha ,&nbsp;Aparna K S ,&nbsp;Praveen Jodalli ,&nbsp;Avinash B R","doi":"10.1016/j.jobcr.2025.03.020","DOIUrl":"10.1016/j.jobcr.2025.03.020","url":null,"abstract":"<div><h3>Background</h3><div>Rheumatoid arthritis (RA) is a persistent inflammatory condition that predominantly affects the joints. However, it also affects the oral health, including temporomandibular joint abnormalities, periodontal disease, and xerostomia. Although these correlations exist, there is little proof that RA is associated with certain markers of dental health. The purpose of this study is to close this gap by assessing the salivary profile and oral health status of RA patients.</div></div><div><h3>Aim</h3><div>To assess and contrast the salivary profile and oral health status of people with rheumatoid arthritis with that of healthy controls.</div></div><div><h3>Objectives</h3><div>To evaluate.</div><div>1. Periodontal health and caries experience using WHO guidelines Adult oral health proforma (2013)</div><div>2. Salivary parameters using a salivary kit.</div><div>3. Cariogram-based assessment of caries risk.</div><div>4. Association between Rheumatoid arthritis and Oral health.</div></div><div><h3>Methods</h3><div>A total of ninety volunteers were enrolled, forty-seven of whom were age-matched healthy individuals and forty-three of whom were patients with rheumatoid arthritis. A structured questionnaire, clinical assessment, and saliva collection were used in the data gathering process. Dental health was evaluated using the WHO Oral Health Assessment Form for Adults (2013), and salivary flow rate and pH were monitored. The Reduced Cariogram model was used to assess the risk of caries. SPSS version 22 was used for the statistical analysis, with significance set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Compared to controls, those with RA had significantly higher rates of dental caries, more gingival bleeding, and deeper periodontal pockets (p &lt; 0.05). Patients with RA also showed decreased salivary pH and decreased stimulated and unstimulated salivary flow rates. Salivary flow rates were found to be negatively correlated with pocket depth, gingival bleeding, and dental caries. Furthermore, the Cariogram showed that patients with arthritis had a higher incidence of dental caries.</div></div><div><h3>Conclusion</h3><div>The findings suggest that dental health is negatively impacted by rheumatoid arthritis. Patients with RA have a higher prevalence of dental caries and periodontitis likely due to impaired salivary profile. These results highlight the significance of thorough oral health evaluations and customized preventive methods for people with rheumatoid arthritis in order to lessen oral health issues.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 600-604"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of ozonized water versus normal saline irrigation with mechanical debridement in chronic periodontitis patients – A clinical study","authors":"Rohith G.N. ,&nbsp;Nayana Patel ,&nbsp;Rita Jha ,&nbsp;Radha Vachhani ,&nbsp;Nisha Verlianey ,&nbsp;Ankit Sant","doi":"10.1016/j.jobcr.2025.03.014","DOIUrl":"10.1016/j.jobcr.2025.03.014","url":null,"abstract":"<div><h3>Background</h3><div>Ozone therapy is a rather novel approach for managing many diseases, encompassing oral disorders such as tooth caries and periodontal disease. It possesses the ability to disrupt microbial cell walls, resulting in rapid cell lysis. Moreover, characteristics of ozone such as anti-inflammation, stimulation and modulation of immunity contribute to mitigating the host response aspect of periodontal disease.</div></div><div><h3>Objective</h3><div>To assess the adjunctive advantages of irrigation of ozonized water in conjunction with mechanical debridement for the treatment of periodontitis.</div></div><div><h3>Methodology</h3><div>50 patients with chronic periodontitis and pocket probing depth ≥4 have been divided into 2 groups i.e. Test (n = 25) and control groups (n = 25). While the control group was administered normal saline irrigation and mechanical debridement, the test group was given ozonized water irrigation. Evaluations were conducted at baseline and four weeks following treatment to determine the plaque score, bleeding score, pocket probing depth, and clinical attachment level.</div></div><div><h3>Results</h3><div>Clinical measures such as clinical attachment level, pocket probing depth, bleeding index, and plaque index, significantly improved with adjunctive ozone water irrigation. The frequency of sites with bleeding on probing that had a pocket depth ≥4 mm was significantly reduced as a result of ozone water irrigation.</div></div><div><h3>Conclusion</h3><div>Ozone irrigation alongside nonsurgical periodontal therapy offers adjunctive benefits by reducing clinical parameters.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 594-599"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lingual foramina on cone beam computed tomography: A retrospective radiographic study","authors":"Om Nemichand Baghele ,&nbsp;Vishnudas Dwarkadas Bhandari ,&nbsp;Pratiksha Shivajirao Late ,&nbsp;Bhushan Rajendra Bangar ,&nbsp;Gauri Mahesh Ugale ,&nbsp;Raghavendra Metri","doi":"10.1016/j.jobcr.2025.03.015","DOIUrl":"10.1016/j.jobcr.2025.03.015","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Context&lt;/h3&gt;&lt;div&gt;Dental surgeons commonly believed that the mandibular site between the mental foramina is the safest for surgical procedures, but there have been numerous reports of significant bleeding accidents in this area. Adequate knowledge about the presence and variation in the morphology of anterior lingual foramina is necessary before starting surgical procedures such as implant placement and ridge augmentation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;The aim of this study was to analyse the presence, frequency, location and relationship of lingual foramen with the inferior border of mandible on Cone Beam Computed Tomography scans (CBCT).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Settings and design&lt;/h3&gt;&lt;div&gt;This retrospective radiographic study was designed and conducted at Maharashtra Institute of Dental Sciences &amp; Research, Latur, India in the Department of Periodontology after approval from the Institutional Ethical Committee.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;100 CBCT scans of dentulous and partially edentulous mandible were randomly acquired and assessed in coronal, sagittal, transverse and cross-sectional views. The CBCT scans made for diagnostic purposes under field of view 15 × 5 cm, 200 μm voxel size, of patients &gt;20 and &lt; 70 years of age of both the genders were included. Presence of cysts, tumours, systemic diseases affecting bone, fractures, previous surgery in the inter-foraminal region and poor quality of CBCT scans were excluded. Total number of foramina, their location and vertical distance between them to inferior border of mandible were recorded.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Statistical analysis used&lt;/h3&gt;&lt;div&gt;Data were entered in data sheets and analysed by using descriptive and inferential statistics. Qualitative data were expressed in terms of proportions while quantitative data were expressed in terms of means and standard deviation. Potential significance was evaluated with Chi square tests.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result&lt;/h3&gt;&lt;div&gt;100 CBCT scans (47 male and 53 females) were randomly analysed. All participants had at least 1 lingual foramen (LF). Total 172 LF were detected on 100 CBCT scans, including 154 (89.5 %) medial LF (MLF) and 18 lateral LF (LLF) (10.4 %). Out of 154 MLF, 63.6 % were present superior and 36.4 % inferior to genial tubercles. Out of 100 subjects, single LF in 44, two in 43, three in 11, four in 1 and five in 1 patient were observed. 94.44 % LLF were observed in canine and 1st premolar region. The mean distance from the MLF and inferior border of mandible was 10.87 ± 2.99 mm, while the same for LLF was 7.1 ± 4.76 mm. About one third of the foramina were in between 13.1 and 16 mm distance from inferior border.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Considering the limitations of the study, the midline lingual foramen can be considered as normal regular anatomic feature with 99 % prevalence while the lateral lingual foramina occur infrequently with a lot of variability in numbers and present commonly","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 585-593"},"PeriodicalIF":0.0,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propolis nanoemulsion extract from celebes stingless bee (Tetragonula biroi) phytochemistry and antibacterial analysis to periodontopathogen bacteria","authors":"Nadya Rafika Amalia ,&nbsp;Theresia Indah Budhy ,&nbsp;Rini Devijanti Ridwan ,&nbsp;Devi Rianti ,&nbsp;Taufan Bramantoro ,&nbsp;Muhammad Luthfi ,&nbsp;Nastiti Faradilla Ramadhani ,&nbsp;Adya Pramusita ,&nbsp;Nurul Aisyah Rizki Putranti ,&nbsp;Albertus Putera Nugraha ,&nbsp;Putri Cahaya Situmorang ,&nbsp;Khairul Anuar Shariff ,&nbsp;Alexander Patera Nugraha","doi":"10.1016/j.jobcr.2025.03.013","DOIUrl":"10.1016/j.jobcr.2025.03.013","url":null,"abstract":"<div><h3>Background</h3><div>Propolis from Sulawesi's stingless bees (<em>Tetragonula biroi</em>) contains antioxidants, more flavonoids than propolis from Apis bees, and the antibacterial ability.</div></div><div><h3>Objective</h3><div>to examine the antibacterial properties of Propolis Nanoemulsion Extract (PNE), which is extracted from the Celebes Stingless Bee (<em>T. biroi</em>), in relation to the periodontopathogen bacteria such as <em>Fusobacterium nucleatum</em> (Fn), <em>Porphyromonas gingivalis</em> (Pg), <em>Aggregatibacter actinomycetemcomitans</em> (Aa), and <em>Provotella intermedia</em> (Pi). This investigation also examines PNE's phytochemistry, particle size analysis (PSA), and zeta potential.</div></div><div><h3>Methods</h3><div>The maceration process with 96 % ethanol was used to create PNE from Celebes stingless bee (<em>T. biroi</em>), which was then subjected to zeta potential measurement and PSA. Phytochemical analysis was used to identify phytochemical constituents in the PNE (T. biroi). Diffusion zone, minimum bactericidal concentration (MBC), and minimum inhibitory concentration (MIC) were used to assess antibacterial efficacy against Aa, Pg, Pi, and Fn. Furthermore, the statistical analysis was used to extract the data.</div></div><div><h3>Results</h3><div>Phenols, alkaloids, and flavonoids were identified; however, triterpenoids and saponins were not. Between 151.28 and 182.2 diameter nanometers (d.nm) was the range of the PNE's diameter. At 1.56 % propolis (<em>T. biroi</em>) concentration, the MIC, MBC, and diffusion zone analysis performed better than at 0.76 %, with a significant difference (p:0.01; p &lt; 0.05) to Aa, Pg, Pi, and Fn.</div></div><div><h3>Conclusions</h3><div>The highest antibacterial activity against Aa, Pg, Pi, and Fn as periodontopathogen bacteria is demonstrated by alkaloids, flavonoids, and phenols in PNE from Celebes (<em>T. biroi</em>) at a concentration of 1.56 %.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 576-584"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of smokeless tobacco with periodontal health of patients seeking treatment at a Dental Hospital setting in Sri Lanka","authors":"Chamilka Asanthi Bandaranayake ,&nbsp;Aruni Pradeepika Liyana Arachchige ,&nbsp;Aruni Tilakaratne ,&nbsp;Ruwan Duminda Jayasinghe","doi":"10.1016/j.jobcr.2025.03.011","DOIUrl":"10.1016/j.jobcr.2025.03.011","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Betel chewing has indeed been an integral part of many cultures in South Asia and beyond for centuries. The practice involves the combination of various ingredients, including areca nut (also known as betel nut), slaked lime, and often tobacco, all wrapped in a betel leaf. This mixture is chewed for its stimulating and psychoactive effects. In addition to its widespread cultural significance, betel chewing has been linked to social rituals, celebrations, and even medical practices in some regions. Despite its cultural importance, it's important to note the health concerns associated with betel chewing. The use of areca nut has been linked to an increased risk of oral cancers, gum disease, and other health issues. Some studies also indicate that the combination of areca nut and tobacco significantly raises the risk of developing these conditions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Main objective&lt;/h3&gt;&lt;div&gt;To assess any association of smokeless tobacco (SLT) with periodontal health of patients seeking dental treatment.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Specific objectives&lt;/h3&gt;&lt;div&gt;To assess the association of periodontal status with oral hygiene habits of patients seeking dental treatment.&lt;/div&gt;&lt;div&gt;To assess the association between smokeless tobacco use with plaque score, bleeding score, BPE (Basic Periodontal Examination) scores and pocket depth measurements.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and method&lt;/h3&gt;&lt;div&gt;This was a cross sectional descriptive study, conducted among adult patients above the age of 18 years, randomly selected from the daily diagnostic clinic of the Dental (Teaching) Hospital, Peradeniya (DTHP), Sri Lanka. The sample size was calculated by using Lawanga and Lamshow sample size calculation method (Lwanga &amp; Lemeshow, 1991) ensuring a 95 % confidence level and 80 % power and a systematic sampling technique. The study instrument was a check-list to obtain socio demographic information and periodontal health status.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 355 adult patients were included in the study, with a mean age of 38 (SD ± 15.2 years) and the age range between 18 and75 years. Out of the total study sample, 120 (34 %) were male and 235 (66 %) were female.&lt;/div&gt;&lt;div&gt;It was identified that age is significantly associated with severe periodontal disease (p &lt; 0.001, OR = 1.043 per year increase) and Plaque score percentile is a strong predictor (p &lt; 0.001, OR = 1.87), indicating a higher plaque score is linked to severe periodontal destruction.&lt;/div&gt;&lt;div&gt;The inferential statistics revealed that there was a statistically significant increase in the plaque scores (P = 0.007), bleeding scores (P = 0.007) and BPE scores (P = 0.003) in smokeless tobacco users when compared with those who do not use smokeless tobacco. Moreover, the periodontal pocket depths (PPD) of smokeless tobacco (SLT) users were significantly greater (P = 0.023) than those of tobacco nonusers (NSLT). Among the SLT users, and those who had good oral","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 570-575"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}