Journal of oral biology and craniofacial research最新文献

{"title":"Evaluating the impact of Matrilin-1 gene polymorphisms on mandibular prognathism: A meta-analysis","authors":"Pooja Kurmi ,&nbsp;Prasad Nalabothu ,&nbsp;Shubhasmita Sahoo ,&nbsp;Henu Kumar Verma ,&nbsp;Srinivas Gosla Reddy ,&nbsp;L.V.K.S. Bhaskar","doi":"10.1016/j.jobcr.2025.03.019","DOIUrl":"10.1016/j.jobcr.2025.03.019","url":null,"abstract":"<div><h3>Introduction</h3><div>Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. This meta-analysis aims to synthesize evidence regarding the link between mandibular prognathism (MP) risk and the polymorphisms in the MATN1 gene.</div></div><div><h3>Materials and methods</h3><div>Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene polymorphisms (rs20566, rs1065755<strong>)</strong> was assessed by calculating odds ratios (ORs) and 95 % CIs. Between studies, heterogeneity was identified using the Cochrane Q test and I² statistics. To assess the robustness of the meta-analysis sensitivity analysis was performed. The web tool MetaGenyo was used to conduct a meta-analysis.</div></div><div><h3>Results</h3><div>A total of four Asian and one Caucasian study were eventually taken for meta-analysis. Overall, the MATN1 rs20566 and rs1065755 polymorphisms are not associated with elevated risk of MP (rs20566 AA + AG versus GG OR = 1.35, 95 % CI = 0.32–5.67; rs1065755 TT + CT versus CC OR = 2.02, 95 % CI = 0.87–4.68). The degree of heterogeneity is found to be large for the MATN1 polymorphisms (for rs20566, I²⁼89 %, and for rs1065755, I²⁼60 %).</div></div><div><h3>Conclusions</h3><div>In conclusion, this meta-analysis did not provide evidence for the link between MATN1 polymorphisms and MP. However, the results conflict with the biological plausibility that matrilin-1 levels modulate cartilage development. Therefore, careful interpretation is needed, and further research is recommended.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 691-695"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of emotional intelligence on patient-dentist relationships: A questionnaire development, validation and pilot study","authors":"J Deepasakthi ,&nbsp;Arthi Balasubramaniam ,&nbsp;M. Karthik","doi":"10.1016/j.jobcr.2025.04.003","DOIUrl":"10.1016/j.jobcr.2025.04.003","url":null,"abstract":"<div><h3>Background</h3><div>The Dentist-Patient relationship is a crucial component of successful dental care. Emotional intelligence (EI) has emerged as an important factor that can shape patient experiences and improve the quality of care. The present study was aimed to develop a questionnaire, validate the questionnaire, and assess how EI influences the dentist-patient relationship.</div></div><div><h3>Materials and methods</h3><div>This study was conducted in four phases. First phase was a focus group discussion with preliminary questionnaire development. Phase II was validation of the preliminary questionnaire and phase III was a pilot study that assessed the internal consistency of the preliminary questionnaire. Phase IV was the survey conducted to assess the influence of EI on dentist-patient relationship using the final questionnaire. A cross-sectional survey was conducted with 200 dentists in the month of September 2024.</div></div><div><h3>Results</h3><div>The CVI and CVR of the final questionnaire was found to be &gt; 0.8 with κ = 81 % suggestive of good intra-rater agreement. The internal consistency of the final questionnaire was good with Cronbach's α value &gt; 0.7. More than 40 % of the participants had an opinion that emotional intelligence helps in making ethical decisions in dental practice. Also, 41.5 % of the dentists suggested for a formal training in emotional intelligence in dental schools.</div></div><div><h3>Conclusion</h3><div>By fostering trust, improving communication, and managing emotional challenges, dental professionals can enhance the quality of care and patient experiences. Implementing EI-focused modules into dental curricula can better prepare future dentists to manage the emotional and psychological aspects of patient care.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 670-676"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of dentin remineralization with Nano-amorphous calcium phosphate-modified bioactive restoratives","authors":"Garima Tyagi ,&nbsp;Sakshi Jain ,&nbsp;Shivani Deshwal ,&nbsp;Shubham Singh ,&nbsp;Nikita Poonia ,&nbsp;Shivangi Sharma","doi":"10.1016/j.jobcr.2025.04.009","DOIUrl":"10.1016/j.jobcr.2025.04.009","url":null,"abstract":"<div><h3>Objective</h3><div>Modern caries management emphasizes minimally invasive techniques to promote remineralization through a balanced pH and mineral ion availability. Bioactive restorative materials, including giomer (Beautiful II, SHOFU Dental GmbH, Japan), and ACTIVA BioACTIVE (Pulpdent Corp., Watertown, MA, USA), release fluoride, calcium, and phosphate to enhance dentin remineralization. Nano-amorphous calcium phosphate (NACP) is a highly reactive mineral with proven remineralization capabilities due to its high surface area and solubility. The synergistic effects of NACP and the bioactive materials remain underexplored. This study evaluates the remineralization potential of giomer and ACTIVA BioACTIVE with and without NACP integration using energy-dispersive X-ray spectroscopy (EDX) microanalysis and Knoop hardness number (KHN) assessments.</div></div><div><h3>Materials and methods</h3><div>Four restorative composite materials: Beautifil II, Beautifil II with NACP, ACTIVA BioACTIVE, and ACTIVA BioACTIVE with NACP, were evaluated on demineralized dentin cavities created in non-carious molars. The mineral content (Ca, P, F) was analyzed via EDX, and the microhardness was measured using KHN. Statistical analyses included analysis of variance (ANOVA) and post hoc Tukey tests.</div></div><div><h3>Results</h3><div>NACP significantly increased calcium and phosphate deposition, with ACTIVA BioACTIVE with NACP demonstrating the highest remineralization (Ca/P ratio: 2.16). Fluoride intensities were higher in the giomer-based materials, promoting fluorapatite formation. KHN analysis revealed that Beautifil II with NACP exhibited the highest hardness, whereas ACTIVA BioACTIVE with NACP showed reduced hardness despite enhanced mineral content.</div></div><div><h3>Conclusion</h3><div>The incorporation of NACP into giomer and ACTIVA BioACTIVE facilitated the accumulation of calcium and phosphate ions, leading to enhanced mineralization.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 684-690"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy in improving the interincisal mouth opening in oral submucous fibrosis: Meta-analysis","authors":"Ashish Bodhade ,&nbsp;Alka Dive ,&nbsp;Monal Yuwanati ,&nbsp;Amol Gadbail ,&nbsp;Dhara Dwivedi","doi":"10.1016/j.jobcr.2025.04.007","DOIUrl":"10.1016/j.jobcr.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Oral submucous fibrosis (OSMF) is a chronic, irreversible collagen metabolic disorder resulting in progressive reduction of mouth opening due to submucosal fibrosis. Currently, the benefit of interincisal mouth opening (IMO) has been attributed to physical therapy. This meta-analysis aimed to find evidence about effectiveness of physiotherapy in increasing of IMO.</div></div><div><h3>Method</h3><div>Literature search was conducted in Scopus, Web of Science, and PubMed databases using \"Oral submucous fibrosis\", \"OSMF\", \"OSF”, “treatment”, “treatment modalities\", \"physiotherapy devices\", “mouth opening exercise device”, “mouth opening”, “mouth opening device”, and \"physiotherapy\" search terms to find the relevant studies published till March 2024. Studies evaluating the effectiveness of physiotherapy alone or in combination in improvement of IMO pre-post intervention in OSMF patients were included. Random-effect analysis was carried out to obtain the pooled IMO. Heterogeneity and publication bias was assessed using the <em>I</em>² and funnel plot. The main outcome variable was increase in IMO which was measured on linear scale.</div></div><div><h3>Results</h3><div>20 studies included in meta-analysis. Physiotherapy alone was found to be effective in improving IMO (4 studies; MD 1.19 [0.18, 2.20]). Further, addition of physiotherapy along with ultrasound (US) (3 studies; MD 3.96 [1.50, 6.42]), medicinal therapy including herbal (13 studies; MD 8.35 [5.18, 11.51]) and surgery (8 studies; MD 21.84 [18.29, 25.38]) improves the IMO.</div></div><div><h3>Conclusion</h3><div>There is evidence of effectiveness of physiotherapy in improving the IMO. However, evidence need to be substantiated with stringent methodology which is lacking in most of studies.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 4","pages":"Pages 677-683"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinicopathological implications of serum IL-33 and sST2 as cancer biomarkers: A narrative review","authors":"Swetha Acharya ,&nbsp;Usha Hegde ,&nbsp;Anirudh B. Acharya","doi":"10.1016/j.jobcr.2025.03.016","DOIUrl":"10.1016/j.jobcr.2025.03.016","url":null,"abstract":"<div><h3>Background</h3><div>Interleukin (IL)-33 and its receptor, soluble suppression of tumorigenicity 2 (sST2), are key players in the immune response and cancer biology. IL-33 can promote tumorigenesis by enhancing cancer cell proliferation and modulating the immune environment to support tumor growth. Conversely, it can also bolster anti-tumor immunity by recruiting and activating immune effector cells. IL-33 plays a role in multiple aspects of cancer biology, such as promoting immune evasion, tumor growth, and metastasis.</div></div><div><h3>Objective</h3><div>This study intends to assess the prognostic significance of serum IL-33 and sST2 in cancer and their association with clinicopathologic characteristics (CPC).</div></div><div><h3>Material &amp; methods</h3><div>Scopus, PubMed electronic databases and other sources were searched and analysed from 2008–2025. The quality of the study was assessed using the Newcastle-Ottawa Quality Assessment Scale.</div></div><div><h3>Results</h3><div>A total of forty-four studies meeting the inclusion criteria were analyzed. These studies primarily employed an observational and analytical designs, with the majority conducted in the Southeast Asian region, particularly in China. Among the studies investigating serum IL-33 levels in cancer, 68% (26/38) reported elevated serum IL-33 levels, with the majority focusing on hepatocellular carcinoma (HCC) and non-small cell lung cancer (NSCLC), followed by breast (BC) and colon rectal cancer (CRC). Additionally, 85% (22/26) of the reports found a significant association between serum IL-33 expression in cancer and CPC. For regulating the availability and activity of IL-33, sST2, a decoy receptor that binds to IL-33, is crucial. Of the studies assessing sST2 in cancer, 55% (12/22) showed elevated sST2 levels, with most focusing on HCC, followed by BC and CRC. Furthermore, 54% (7/13) of these studies identified a significant correlation between sST2 levels and CPC.</div></div><div><h3>Conclusion</h3><div>The detection of increased serum IL-33 across various malignancies highlights its potential as an emerging biomarker for cancer detection and prognosis. Similarly, elevated sST2 levels have been observed in different cancers and are linked to poor prognosis, further highlighting its potential as a biomarker for tumor progression. The IL-33/ST2 signaling pathway could offer new cancer treatment strategies by enhancing immune responses while mitigating tumor-promoting effects. This study explores the roles of IL-33 and sST2 as biomarkers, their relevance in cancer diagnostics and therapeutics, and their correlation with clinical outcomes across different cancer types.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 645-658"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worst pattern of invasion in oral squamous cell carcinoma: An independent prognostic indicator","authors":"Manahil Rahat ,&nbsp;Umair Aslam Shahzad ,&nbsp;Nighat Ara ,&nbsp;Hafeez Ud din ,&nbsp;Bushra Parveen ,&nbsp;Naveed Khan ,&nbsp;Saadia Munir ,&nbsp;Hassan Mumtaz","doi":"10.1016/j.jobcr.2024.12.008","DOIUrl":"10.1016/j.jobcr.2024.12.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral squamous cell carcinoma is a malignancy that is biologically aggressive.</div></div><div><h3>Objective</h3><div>To investigate the correlation between various histopathological factors and the worst patterns of invasion at the tumor-host interface, which were classified as cohesive (1–3) and non-cohesive (4&amp;5).</div></div><div><h3>Methods</h3><div>Neck dissections were performed on 81 cases of oral squamous cell carcinoma those had been diagnosed. The selection was limited to paraffin-embedded blocks that contained sections from the tumor. Tumor staging, nodal staging and other factors such as lymphovascular invasion, perineural invasion, extra nodal extension, depth of invasion, margin status and tumor differentiation grades were documented.</div></div><div><h3>Results</h3><div>The findings indicate a higher frequency of non-cohesive worst invasion patterns in numerous anatomical sites. A prediction accuracy of 69.1 % was obtained from the logistic regression analysis, suggesting that the predictive performance has also improved. The chi square test results demonstrated a statistically significant correlation between the variable of interest and extranodal extension showing a p value of 0.008 while lymph node status also showed significant with a p value of 0.000. Another factor that depicted a significance with worst pattern of invasion was tumor margin status having a p value of 0.046. Lymphovascular invasion and the worst pattern of invasion also exhibited a statistically significant correlation, with a p-value of 0.013.</div></div><div><h3>Conclusion</h3><div>The results of this investigation indicate that aggressive tumor biology is associated with non-cohesive worst pattern of invasion. Non-cohesive worst pattern of invasion is associated with moderate differentiation grade, lymphovascular invasion, perineural invasion, extranodal extension, closed or involved tumor margins and nodal metastases.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 638-644"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Polydeoxyribonucleic Acid (PDRN) in periodontal regeneration: A systematic review of clinical outcomes","authors":"Ranjith Mari ,&nbsp;Jaiganesh Ramamurthy ,&nbsp;K. Rudhra ,&nbsp;Nitya Krishnaswamy","doi":"10.1016/j.jobcr.2025.03.021","DOIUrl":"10.1016/j.jobcr.2025.03.021","url":null,"abstract":"<div><h3>Background</h3><div>Periodontal disease is a major dental health concern due to its impact on the supporting structures of teeth, including the alveolar bone and periodontal ligament. Polydeoxyribonucleic Acid (PDRN) has shown promise in promoting tissue regeneration through anti-inflammatory effects and angiogenesis, crucial for periodontal healing.</div></div><div><h3>Objective</h3><div>To evaluate the clinical effectiveness of Polydeoxyribonucleic Acid (PDRN) in periodontal regeneration through a systematic analysis of available studies.</div></div><div><h3>Methods</h3><div>This review followed PRISMA guidelines and included randomized controlled trials (RCTs), cohort, and case-control studies assessing PDRN's effects on periodontal regeneration. A comprehensive search in PubMed, Scopus, Web of Science, and Embase was conducted using keywords related to PDRN and periodontal regeneration. Primary outcomes included clinical attachment level (CAL) gain, probing depth reduction, and bone fill. Two reviewers independently assessed study eligibility and extracted data on PDRN application methods, dosages, and observed outcomes.</div></div><div><h3>Results</h3><div>Among the four studies that met the inclusion criteria, significant improvements in CAL, bone fill, and probing depth reduction were consistently observed in PDRN-treated sites compared to controls. Animal studies also demonstrated enhanced bone quality, reduced inflammation, and a conducive environment for cell proliferation. Clinical trials indicated that PDRN, as an adjunct to conventional therapy, produced more favorable outcomes in periodontal healing. PDRN's activation of adenosine A2A receptors and VEGF expression promoted angiogenesis and modulated inflammatory responses, aiding regeneration.</div></div><div><h3>Conclusion</h3><div>PDRN appears to offer substantial benefits in periodontal regeneration by enhancing bone and tissue healing and reducing inflammatory responses. While promising, further clinical trials are necessary to determine optimal dosing and long-term effectiveness. This systematic review provides evidence supporting PDRN as a potential adjunctive treatment for periodontitis, with implications for enhancing clinical outcomes in periodontal therapy.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 624-630"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative fractal analysis of mandibular condyles in temporomandibular disorder and non-temporomandibular disorder patients using cone-beam computed tomography","authors":"Kavali Laxmi Swetha,&nbsp;Sairam Vankadara,&nbsp;Nerrugatti Shiny chelshiya,&nbsp;Bhaandhavi Akula","doi":"10.1016/j.jobcr.2025.03.017","DOIUrl":"10.1016/j.jobcr.2025.03.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Temporomandibular joint (TMJ) anatomy and microstructure is complex. Multifactorial disorders of the TMJ may affect the musculoskeletal and osseous structures of the joint. It is highly beneficial to detect these changes early in the development of temporomandibular disorders (TMDs) in order to prevent their progression. There are several pathological conditions that can affect the trabecular bone of the mandibular condyle in the TMJ. In order to analyse these changes, it is possible to measure them through the use of fractal dimensional analysis, as they are natural fractals.</div></div><div><h3>Aim &amp; objective</h3><div>Fractal analysis was used in this study to examine the trabecular pattern of the mandibular condyle, with the objective of assessing fractal dimension changes in mandibular condyles for TMD diagnosis.</div></div><div><h3>Methods</h3><div>The 120 subjects are divided into two groups, a Control group (non-TMD's-60 each) and a Study group (TMD's-60 each). The study includes participants diagnosed with TMD's according to RDC/TMD Axis -I &amp; Axis-II (Research diagnostic criteria,2014). Cone bean computed Tomography (CBCT) images are captured and converted into JPEG images. A fractal dimensional analysis is performed on the condylar portion of the trabecular bone. With Image J software version 1.51 program (National Institutes of Health, Bethesda, MD @; <span><span>https://imagej.nih.gov/ij/download.html</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>The present study found that subjects with TMD had significantly lower fractal values than controls (p &lt; 0.001 on right side and left side p &lt; 0.021).</div></div><div><h3>Conclusion</h3><div>The study group had lower fractal values than the control group. This study in additional hypothesized fractal values for each type of TMD. The use of CBCT can enhance the diagnosis of TMD.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 631-637"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of chronic periodontitis and type 2 diabetes mellitus on resistin levels of gingival crevicular fluid- a systematic review and meta-analysis","authors":"Dax Abraham ,&nbsp;Alpa Gupta ,&nbsp;Arun Kumar Duraisamy ,&nbsp;Mrinalini Mrinalini","doi":"10.1016/j.jobcr.2025.03.022","DOIUrl":"10.1016/j.jobcr.2025.03.022","url":null,"abstract":"<div><h3>Aim</h3><div>Chronic periodontitis (CP), a prevalent inflammatory dental disease, has been linked to systemic conditions like Type 2 Diabetes Mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate resistin levels in the Gingival Crevicular Fluid (GCF) of CP individuals with T2DM. The objective was to determine if resistin could be a potential biomarker for periodontal disease in T2DM individuals.</div></div><div><h3>Methods</h3><div>The review included data from seventeen clinical studies that investigated resistin levels in GCF of individuals diagnosed with CP and T2DM. Data were sourced from PubMed, Scopus, and EBSCOhost, selected for their extensive coverage of medical and dental research, ensuring thorough retrieval of relevant studies. From the initial seventeen studies, five complied with the strict inclusion criteria for meta-analysis.</div></div><div><h3>Results</h3><div>Using a comprehensive meta-analysis, the significance of GCF Resistin levels in individuals with CP and T2DM relative to the healthy groups was examined. In addition, a meta-analysis was carried out to look into the relationship between periodontal probing depth (PPD) and CP and T2DM. The results indicated that individuals with T2DM and CP had significantly higher GCF resistin levels than the other groups. Furthermore, the PPD in T2DM with CP was significantly greater than in the other groups.</div></div><div><h3>Conclusion</h3><div>The present review highlights the potential role of resistin as a biomarker to diagnose individuals with chronic periodontitis and T2DM.</div></div><div><h3>Clinical significance</h3><div>The significantly elevated levels of resistin suggest that resistin could serve as a potential biomarker for T2DM in individuals with CP. This could lead to improved methods of early diagnosis and treatment, which could enhance individual outcomes and quality of life.</div></div><div><h3>Prospero registration</h3><div>The registration number CRD42023467186.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 612-623"},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cariogenic potential and pharmacokinetics of Licorice and Xylitol infused chewing gum","authors":"Jencia Amaly ,&nbsp;Ramya Ramadoss ,&nbsp;K. Nitya ,&nbsp;Sundar Sandhya ,&nbsp;Suganya Panneer Selvam ,&nbsp;K. Hema Shree ,&nbsp;G. Radha","doi":"10.1016/j.jobcr.2025.03.012","DOIUrl":"10.1016/j.jobcr.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Dental caries remains a global health challenge despite advancements in prevention. Traditional approaches focus on mechanical plaque removal and fluoride use, but innovative, non-invasive solutions are increasingly sought. Chewing gum, as a delivery system for bioactive ingredients, offers a convenient method for improving oral health. Xylitol, licorice, and lemon balm, known for their anti-cariogenic and antimicrobial properties, were incorporated into a novel chewing gum to evaluate its potential in preventing caries.</div></div><div><h3>Methods</h3><div>The chewing gum was formulated using beeswax, glycerin monostearate, xanthan gum, xylitol, lemon balm, and licorice. Physicochemical properties were assessed through Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Rheological properties, including elasticity and viscosity, were analyzed to ensure optimal texture. Antimicrobial activity was evaluated using the Minimum Inhibitory Concentration (MIC) method against key cariogenic bacteria, while flavor dynamics and in-silico docking and ADMET analysis provided additional insights.</div></div><div><h3>Results</h3><div>FTIR and XRD confirmed the successful integration of bioactive components and an amorphous matrix structure, promoting controlled release and stability. Antimicrobial assays showed the gum's effectiveness against Streptococcus mutans (MIC 0.20 mg/mL), with varying efficacy against other pathogens. Rheological analysis revealed xanthan gum as a key contributor to elasticity and viscosity, ensuring chewability and stability. Flavor release dynamics highlighted prolonged taste perception, with licorice providing sustained intensity. In-silico analysis supported the bioavailability and favorable pharmacokinetics of the ingredients.</div></div><div><h3>Conclusion</h3><div>This novel chewing gum demonstrates significant potential as an anti-cariogenic product with a balanced formulation of functional, structural, and sensory properties. Future research, including clinical trials and consumer testing, will be essential to optimize its effectiveness and marketability, addressing the demand for user-friendly oral health solutions.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 3","pages":"Pages 605-611"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}