Hyaluronic acid fillers and botulinum toxin type A: Cross-Sectional analysis for optimizing outcomes based on sex and age

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-09-01 DOI:10.1016/j.jobcr.2025.08.029

Ana Paula Pereira da Silva , Océane Mantel , Jussara Marinho Dias Frasson , Mariana Barbosa Câmara-Souza , Josué Júnior Pierote Araújo , Renato Assis Machado

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引用次数: 0

Abstract

Objective

To analyze treatment patterns, dosing variations, and reapplication rates of botulinum toxin type A (BoNT-A) and hyaluronic acid injections, with a focus on sex- and age-related differences in outcomes.

Methods

A prospective analysis was conducted on 164 patients treated with BoNT-A and/or hyaluronic acid injections. Patients were categorized by sex and age (<50 years or ≥50 years). Data on dosage, treatment regions, and reapplications were collected and analyzed for statistical significance.

Results

The study highlighted distinct differences in the application of BoNT-A and hyaluronic acid based on sex and age. For botulinum toxin, the average dose per patient was 55.3 ± 12.7 units. Men received higher doses in the procerus (7.7 ± 2.6 vs.5.7 ± 2.2 units, p = 0.02) and nasal muscles (6.5 ± 2.7 vs.5.3 ± 1.7 units, p = 0.02). Significant age-related differences were observed in the orbicularis oculi (11.0 ± 4.1 vs.14.3 ± 5.4 units, p = 0.02) and corrugator muscles (10.7 ± 3.0 vs.10.5 ± 2.2 units, p = 0.02), with patients ≥50 years requiring higher reapplication doses (p = 0.0001). For hyaluronic acid, men required greater volumes in the mandible (p = 0.0001), reflecting differences in anatomical preferences, whereas women received larger volumes in the lips (p = 0.01), chin (p = 0.02), pre-jowls (p = 0.02), and under-eye regions (p = 0.003), which align with more delicate and aesthetic enhancements.

Conclusion

Significant sex- and age-based differences were observed in the application of BoNT-A and hyaluronic acid. Men required higher doses for structural enhancement, while women showed a preference for treatments in aesthetic regions. Patients ≥50 years required higher doses and reapplications, reflecting age-related anatomical changes. These findings highlight the importance of individualized treatment strategies for optimizing outcomes in aesthetic procedures.

查看原文本刊更多论文

透明质酸填充剂和A型肉毒毒素：基于性别和年龄优化结果的横断面分析

目的分析A型肉毒毒素（BoNT-A）和透明质酸注射的治疗模式、剂量变化和重复应用率，重点分析与性别和年龄相关的结果差异。方法对164例接受BoNT-A和/或透明质酸注射治疗的患者进行前瞻性分析。患者按性别和年龄（50岁或≥50岁）分类。收集剂量、治疗区域和再次应用的数据并分析其统计学意义。结果本研究强调了BoNT-A和透明质酸的应用在性别和年龄上的明显差异。肉毒毒素的平均剂量为55.3±12.7单位。男性在前肌（7.7±2.6 vs.5.7±2.2单位，p = 0.02）和鼻肌（6.5±2.7 vs.5.3±1.7单位，p = 0.02）中接受较高剂量。在眼轮匝肌（11.0±4.1 vs.14.3±5.4单位，p = 0.02）和瓦楞肌（10.7±3.0 vs.10.5±2.2单位，p = 0.02）中观察到显著的年龄相关差异，≥50岁的患者需要更高的重复应用剂量（p = 0.0001）。对于透明质酸，男性需要更大的下颌骨体积（p = 0.0001），这反映了解剖学偏好的差异，而女性需要更大的嘴唇体积（p = 0.01）、下巴（p = 0.02）、前下颌（p = 0.02）和眼下区域（p = 0.003），这些区域与更精致和美观的增强相一致。结论BoNT-A和透明质酸的应用存在明显的性别和年龄差异。男性需要更高剂量的结构增强，而女性则倾向于在审美区域进行治疗。≥50岁的患者需要更高的剂量和重新应用，反映出与年龄相关的解剖变化。这些发现强调了个性化治疗策略对优化美容手术结果的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.