Journal of oral biology and craniofacial research最新文献

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Characterization of upper airway airflow dynamics in young adults with isolated Robin sequence: An exploratory investigation 分离Robin序列的年轻成人上呼吸道气流动力学特征:一项探索性调查
Journal of oral biology and craniofacial research Pub Date : 2025-02-10 DOI: 10.1016/j.jobcr.2025.01.009
Maria Noel Marzano-Rodrigues , Sergio Henrique Kiemle Trindade , Ivy Kiemle Trindade-Suedam
{"title":"Characterization of upper airway airflow dynamics in young adults with isolated Robin sequence: An exploratory investigation","authors":"Maria Noel Marzano-Rodrigues ,&nbsp;Sergio Henrique Kiemle Trindade ,&nbsp;Ivy Kiemle Trindade-Suedam","doi":"10.1016/j.jobcr.2025.01.009","DOIUrl":"10.1016/j.jobcr.2025.01.009","url":null,"abstract":"<div><div>Impaired upper airway dimension in adults with Isolated Robin Sequence (IRS) can alter airflow dynamics, increasing the risk of pharyngeal collapse and the onset of obstructive sleep apnea. This study aimed to characterize the upper airways of six young adults (20.83 ± 6.40 years) with IRS, using computational fluid dynamics. Upper airways of six patients were reconstructed using 3D segmentation, generating unstructured hybrid meshes with ≥4 million tetrahedral elements. Flow simulations at 15 l/min were solved using the realizable k-ε model and the finite volume method. Morphophysiological variables assessed were: total airway volumes, minimal cross-sectional areas, average pressure, velocity magnitude, wall shear stress, turbulent kinetic energy (k) production, and resistance. Airway volume corresponded to 29.32 ± 4.65 cm³ and minimal cross-sectional area was 1.00 ± 0.55 cm<sup>2</sup>. Pressure drop, airway resistance to airflow, velocity of the airflow and turbulent kinetic energy corresponded to 31.341 ± 15.837 Pa, 0.125 ± 0.063 (Pa s/ml), 1.882 ± 0.514 (m/s) and 0.152 ± 0.056 (m2/s2). The total airway volume exhibited a strong negative correlation with airway resistance (−0.899) and the inlet-to-outlet pressure drop (−0.899). The minimal cross-sectional area of the pharynx at the retroglossal level showed a strong negative correlation (−0.912) with the area-weighted average velocity magnitude of the airflow and with k production (−0.924). In conclusion, airway volume reduction and retroglossal obstruction in young adults with IRS are associated with altered fluid flow characteristics, including increased velocity magnitude, pressure drop, resistance, and turbulent kinetic energy production. These changes may increase the effort to breathe and predispose patients to sleep-disordered breathing.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 234-239"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis 评估炎症生物标志物作为种植体周围炎诊断工具的作用
Journal of oral biology and craniofacial research Pub Date : 2025-02-09 DOI: 10.1016/j.jobcr.2025.01.015
Ayan Saxena , Pavitra Kumar Rastogi , Nand Lal , Umesh Pratap Verma , Rameshwari Singhal , Md. Kaleem Ahmad
{"title":"Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis","authors":"Ayan Saxena ,&nbsp;Pavitra Kumar Rastogi ,&nbsp;Nand Lal ,&nbsp;Umesh Pratap Verma ,&nbsp;Rameshwari Singhal ,&nbsp;Md. Kaleem Ahmad","doi":"10.1016/j.jobcr.2025.01.015","DOIUrl":"10.1016/j.jobcr.2025.01.015","url":null,"abstract":"<div><h3>Background</h3><div>Most studies have analyzed the presence of cytokines in Gingival crevicular fluid (GCF) in different periodontal diseases, but very limited studies have been conducted on Peri-implant crevicular fluid (PICF) in peri-implantitis.</div></div><div><h3>Aim</h3><div>The present study was conceptualized to explore the levels of Interleukin (IL)-1β and Interleukin (IL)-6 as a diagnostic marker in peri-implantitis.</div></div><div><h3>Materials and methods</h3><div>A total of 40 patients each having at least one dental implant were enrolled in the study. Clinical parameters were recorded around each implant and tooth nearest to it. Gingival crevicular fluid (GCF)/Peri-implant crevicular fluid (PICF) was collected to evaluate the concentration of IL‐1β and IL‐6. Conservative treatment was performed in peri-implantitis cases, 3 months after treatment their clinical parameters, IL-1β and IL-6 levels were recorded and compared with their pre-treatment values.</div></div><div><h3>Results</h3><div>Clinical parameters like Modified Plaque Index (MPI), Modified Bleeding Index (MBI) and Probing Pocket Depth (PPD) were statistically significantly higher in the peri-implantitis group as compared to the healthy implant group and healthy teeth group. IL-1β and IL-6 levels were also statistically significantly higher in the peri-implantitis group in comparison to healthy implants and healthy teeth group.</div></div><div><h3>Conclusion</h3><div>The study concludes that biomarkers in PICF can be used as a diagnostic tool to supplement the diagnosis of peri-implantitis along with the use of clinical parameters to make an early diagnosis of peri-implantitis possible.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 228-233"},"PeriodicalIF":0.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT–A double-blinded, randomized placebo-controlled trial 冷冻治疗、激光治疗和韧带内注射地塞米松对单次访视后疼痛的影响
Journal of oral biology and craniofacial research Pub Date : 2025-02-09 DOI: 10.1016/j.jobcr.2025.01.005
Dr Sana Fatima , Dr Sonali Taneja , Dr Vivek Aggarwal , Dr Akriti Dheer , Dr Punya Taneja
{"title":"Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT–A double-blinded, randomized placebo-controlled trial","authors":"Dr Sana Fatima ,&nbsp;Dr Sonali Taneja ,&nbsp;Dr Vivek Aggarwal ,&nbsp;Dr Akriti Dheer ,&nbsp;Dr Punya Taneja","doi":"10.1016/j.jobcr.2025.01.005","DOIUrl":"10.1016/j.jobcr.2025.01.005","url":null,"abstract":"<div><h3>Aim</h3><div>This study designed to evaluate the effect of adjuvant therapies on the intensity of post-treatment pain after single-visit RCT in molars with symptomatic apical periodontitis.</div></div><div><h3>Method</h3><div>ology: This trial was reported according PRIRATE 2020 guidelines and registered with CTRI/2019/03/018,153.100 patients diagnosed with symptomatic apical periodontitis with a preoperative pain allocated to 4 groups,Group-1: placebo,Group-2:Intraligamentary injection of dexamethasone, Group-3:cryotherapy, Group-4: laser therapy. Patients were instructed to record postoperative pain intensity and intake of analgesics after 6,12,24,48 &amp; 72 h. Intergroup pain intensity was tested by using the Kruskal-Wallis test. The need for painkillers between groups was analyzed using Chi-square test. P value of &lt;0.05 was considered statistically significant.</div><div>R<strong>esults</strong>: Patients in the placebo group exhibited higher intensity. Group 3 showed lesser pain at all-time intervals.</div></div><div><h3>Conclusion</h3><div>All the adjuvant pain management therapies reduced the intensity of postoperative pain and the frequency of intake of analgesics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 221-227"},"PeriodicalIF":0.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced deep learning techniques for recognition of dental implants 牙种植体识别的先进深度学习技术
Journal of oral biology and craniofacial research Pub Date : 2025-02-08 DOI: 10.1016/j.jobcr.2025.01.016
Veena Benakatti , Ramesh P. Nayakar , Mallikarjun Anandhalli , Rohit sukhasare
{"title":"Advanced deep learning techniques for recognition of dental implants","authors":"Veena Benakatti ,&nbsp;Ramesh P. Nayakar ,&nbsp;Mallikarjun Anandhalli ,&nbsp;Rohit sukhasare","doi":"10.1016/j.jobcr.2025.01.016","DOIUrl":"10.1016/j.jobcr.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Dental implants are the most accepted prosthetic alternative for missing teeth. With growing demands, several manufacturers have entered the market and produce a variety of implant brands creating a challenge for clinicians to identify the implant when the necessity arises. Currently, radiographs are the only tools for implant identification which is inherently a complex process, hence the need for implant identification technique. Artificial intelligence capable of analysing images in a radiograph and predicting implant type is an efficient tool. The study evaluated an advanced deep learning technique, DEtection TRanformer for implant identification.</div></div><div><h3>Methods</h3><div>A transformer-based deep learning technique, DEtection TRanformer was trained to identify implants in radiographs. A dataset of 1138 images consisting of five implant types captured from periapical and panoramic radiographs was chosen for the study. After augmentation, a dataset of 1744 images was secured and then split into training, validation and test datasets for the model. The model was trained and evaluated for its performance.</div></div><div><h3>Results</h3><div>The model achieved an overall precision of 0.83 and a recall score of 0.89. The model achieved an F1-score of 0.82 indicating a strong balance between recall and precision. The Precision-Recall Curve, with an AUC of 0.96, showed that the model performed well across various thresholds. The training and validation graphs showed a consistent decrease in the loss functions across classes.</div></div><div><h3>Conclusion</h3><div>The model showed high performance on the training data, though it faced challenges with unseen validation data. High precision, recall and F1 score indicate the model's potential for implant identification. Optimizing this model for a balance between accuracy and efficiency will be necessary for real-time medical imaging applications.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 215-220"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharyngeal airway dimensions and adipose distribution in the minipig 小型猪咽部气道尺寸及脂肪分布。
Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.004
Doris H. Rosero Salazar , Riana Grewal , Anuj Vimawala , Daniel F. Leotta , Swati R. Levendovszky , Zi-Jun Liu
{"title":"Pharyngeal airway dimensions and adipose distribution in the minipig","authors":"Doris H. Rosero Salazar ,&nbsp;Riana Grewal ,&nbsp;Anuj Vimawala ,&nbsp;Daniel F. Leotta ,&nbsp;Swati R. Levendovszky ,&nbsp;Zi-Jun Liu","doi":"10.1016/j.jobcr.2024.12.004","DOIUrl":"10.1016/j.jobcr.2024.12.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model.</div></div><div><h3>Materials and methods</h3><div>Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance imaging (MRI) was performed using dynamic turbo-field echo (TFE)-sequence with respiratory gating and adipose-weighted sequence. Respiratory airflow velocity, pressure, and volume were also recorded. The sizes of velopharyngeal and oropharyngeal airway, and retroglossal areas were measured coronally during inspiration and expiration. The airway volumes from the nasal cavity to the retroglossal space were segmented, reconstructed, and evaluated in sagittal views. The adipose distribution in the tongue base, soft palate, pharyngeal wall, tongue body, and masseter muscle (reference) were segmented and measured in sagittal and coronal planes.</div></div><div><h3>Results</h3><div>The velopharyngeal and oropharyngeal areas were larger in inspiration than in expiration. These areas were also larger than that in the retroglossal space (p &lt; 0.05). The nasal cavity showed a larger volume than that of the pharyngeal regions (p &lt; 0.05). The adipose distribution was larger in the posterior region of the tongue base and anterior soft palate, both larger than the masseter muscle (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The larger oropharyngeal dimensions and increased adipose distribution in the tongue base contribute to the functional morphology of the pharyngeal airway in the healthy minipig. These data provide the baseline for further analysis in enlarged and reduced tongue base minipig models.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 77-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of remineralizing potential of four enamel remineralising agents using SEM-EDX – An in-vitro study 用SEM-EDX对四种牙釉质再矿化剂再矿化电位的比较评价——一项体外研究。
Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2025.01.006
R. Raj
{"title":"Comparative evaluation of remineralizing potential of four enamel remineralising agents using SEM-EDX – An in-vitro study","authors":"R. Raj","doi":"10.1016/j.jobcr.2025.01.006","DOIUrl":"10.1016/j.jobcr.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>Compare the remineralisation potential of four enamel remineralising agents on artificially demineralized enamel surface using Scanning electron microscopy- Energy dispersive x-ray.</div></div><div><h3>Materials and methods</h3><div>75 extracted maxillary and mandibular premolars coated with acid-resistant nail varnish, were stored in demineralising solution for 96 h to produce artificial caries lesions. The samples were divided into 5 groups (n = 15), Control (Demineralized- No treatment), Group I samples were treated with casein phosphoprotein-amorphous calcium phosphate (CPP-ACP), Group II with self-assembling peptide (SAP-14), Group III with tri-calcium phosphate (f-TCP) and Group IV with Bioactive glass (BAG), respectively. The pH cycling model was followed for 21 days. The samples were analysed via SEM-EDX (Carl Zeiss, Germany; Model: Merlin Compact) for qualitative assessment and quantitative analysis of calcium and phosphorous. The data were analysed for multiple group comparison using IBM SPSS version 20 with one-way ANOVA followed by a paired <em>t</em>-test.</div></div><div><h3>Results</h3><div>Calcium/Phosphorous ratio of all experimental groups; Group 1(1.92 ± .17), Group 2 (1.98 ± .16), Group 3 (1.81 ± .03), Group 4 (1.75 ± .08) was statistically different (p &lt; 0.0005) from Control; while there was no difference between Group I and Group II (p = 0.33).</div></div><div><h3>Conclusion</h3><div>All experimental groups showed comparable remineralising potential. Even though no statistically significant difference is seen between Group I and Group II, after correlating with surface analysis it was concluded that Group II showed the greatest remineralising potential.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 183-187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental implant placement accuracy with robotic surgery compared to free-hand, static and dynamic computer assisted techniques: Systematic review and meta-analysis 与徒手、静态和动态计算机辅助技术相比,机器人手术的牙种植体放置准确性:系统回顾和荟萃分析。
Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.005
Hariram Sankar , M. Shalini , Anjana Rajagopalan , Satish Gupta , Amit Kumar , Rukhsar Shouket
{"title":"Dental implant placement accuracy with robotic surgery compared to free-hand, static and dynamic computer assisted techniques: Systematic review and meta-analysis","authors":"Hariram Sankar ,&nbsp;M. Shalini ,&nbsp;Anjana Rajagopalan ,&nbsp;Satish Gupta ,&nbsp;Amit Kumar ,&nbsp;Rukhsar Shouket","doi":"10.1016/j.jobcr.2024.12.005","DOIUrl":"10.1016/j.jobcr.2024.12.005","url":null,"abstract":"<div><h3>Background</h3><div>This systematic review and meta-analysis compared the accuracy of robotic-assisted dental implant placement (r-CAIS) with conventional freehand, static computer-assisted (s-CAIS), and dynamic computer-assisted (d-CAIS) techniques.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Google Scholar, Semantic Scholar, and the Cochrane Library from January 2000 to January 2024. Studies meeting PICOST criteria, including clinical and in vitro studies, were included. Data on coronal, apical, and angular deviations were extracted for meta-analysis. The risk of bias (RoB) was assessed using the QUIN RoB and JBI RoB tools.</div></div><div><h3>Results</h3><div>A total of 134 models and 100 patients with edentulous and partially edentulous arches were included. Eight studies (four in vitro, four in vivo) were reviewed, demonstrating that r-CAIS offers superior accuracy compared to freehand, s-CAIS, and d-CAIS techniques. Among the studies, two in vitro and two in vivo studies had a low RoB, while others had a high RoB. The meta-analysis of five studies showed significant improvements in coronal, apical, and angular deviations with robotic systems.</div></div><div><h3>Conclusion</h3><div>Robotic-assisted systems showed greater accuracy than traditional non-robotic systems. However, this finding should be interpreted with caution due to the limited number of clinical studies and potential funding biases. Moreover, the high cost of robotic systems presents challenges for routine clinical implementation. Future research should focus on cost-effectiveness and seek broader clinical validation.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 69-76"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Binaural auditory beats vs music of choice as audio distraction behaviour guidance technique among children: A randomized controlled trial 双耳节拍与音乐选择作为儿童音频干扰行为指导技术:一项随机对照试验。
Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.019
Bhuvanesh N. Bhusari, Shivayogi M. Hugar, Niraj Gokhale, Shweta Kajjari, Sanika Karmarkar, Varunika Sahai
{"title":"Binaural auditory beats vs music of choice as audio distraction behaviour guidance technique among children: A randomized controlled trial","authors":"Bhuvanesh N. Bhusari,&nbsp;Shivayogi M. Hugar,&nbsp;Niraj Gokhale,&nbsp;Shweta Kajjari,&nbsp;Sanika Karmarkar,&nbsp;Varunika Sahai","doi":"10.1016/j.jobcr.2024.12.019","DOIUrl":"10.1016/j.jobcr.2024.12.019","url":null,"abstract":"<div><h3>Background</h3><div>Binaural beat is created by presenting two different pure-tone sine waves with less than a 30Hz difference dichotically. In dental settings, children listening to familiar music during treatments gain control over the anxiety caused by tools like the airotor or syringe, creating a comforting, familiar environment.</div></div><div><h3>Aim</h3><div>To evaluate and compare anxiety level during restorative treatment using No Music, Music of choice and Binaural Auditory Beats as Audio distraction behaviour guidance technique in children aged 6–12 years.</div></div><div><h3>Methods</h3><div>In-vivo, double-blind, three-arm, parallel-group randomized study was conducted in the department of pediatric and preventive dentistry where 75 participants were allocated into 3 groups. The teeth with Class I cavity in primary and permanent molars were prepared and restored. Anxiety was measured pre- and post-intervention using Pulse oximeter and Venham's picture test.</div></div><div><h3>Results</h3><div>Children who were treated with Binaural beats and Music of choice showed reduction in anxiety levels as indicated by lower anxiety scores in Venham picture test and pulse rate values as compared to the control group.</div></div><div><h3>Conclusion</h3><div>Binaural auditory beats and Music of choice can be used effectively as a non-invasive treatment modality to reduce anxiety in apprehensive pediatric patients.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 163-169"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study 评估外显子非编码RNA MALAT1在OSCC中与发育不良和正常的比较:一项横断面研究。
Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.018
Ramya Sekar , Selvaraj Jayaraman , VishnuPriya Veeraraghavan , Kalaiselvi Krishnamoorthy , Shubhra Chauhan Aramanai , Sathan Raj Natarajan
{"title":"Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study","authors":"Ramya Sekar ,&nbsp;Selvaraj Jayaraman ,&nbsp;VishnuPriya Veeraraghavan ,&nbsp;Kalaiselvi Krishnamoorthy ,&nbsp;Shubhra Chauhan Aramanai ,&nbsp;Sathan Raj Natarajan","doi":"10.1016/j.jobcr.2024.12.018","DOIUrl":"10.1016/j.jobcr.2024.12.018","url":null,"abstract":"<div><h3>Objective</h3><div>This study explores the role of MALAT1 as a valuable target for creating minimally-invasive diagnostic methods and personalized treatments in the management of OSCC. It focuses on evaluating the role of exosomal MALAT1 in the progression of dysplasia to OSCC by influencing the PI3K/AKT pathway.</div></div><div><h3>Method</h3><div>This cross-sectional study evaluated MALAT1 expression and PI3K/AKT pathway components in exosomes derived from plasma samples of patients with various stages of oral dysplasia, OSCC and compared with normal. RNA concentration was estimated, real-time polymerase chain reaction (qPCR) was used for quantitative analysis. Gene expression levels of MALAT1, PI3K, AKT1, and PTEN were analysed and compared across groups using one way ANOVA and Post-hoc Tukey analysis was performed for pairwise comparisons to assess correlations between MALAT1 expression and PI3K/AKT pathway components.</div></div><div><h3>Result</h3><div>MALAT1 was found to be overexpressed in OSCC in comparison to normal, significantly (<em>p</em> &lt; 0.001∗). There was no significant change in expression pattern of MALAT1 between dysplastic patients and normal, yet, significant association was found on corelation analysis between expression pattern of MALAT1 and PI3K/AKT/PTEN (<em>p</em> 0.001∗) among individuals of dysplasia and OSCC. As well pairwise comparisons of MALAT1 expression levels between all three stages of dysplasia showed significant association (<em>p</em> &lt; 0.001∗).</div></div><div><h3>Conclusion</h3><div>MALAT1 stands out as a key player in the complex landscape of OSCC pathogenesis, impacting tumorigenesis, metastasis, and treatment outcomes through multifaceted molecular mechanisms. Continued research into MALAT1's regulatory roles and its interactions within the tumor microenvironment holds promise for uncovering novel therapeutic targets and biomarkers that could redefine the management of OSCC in the future.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 123-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of patient comfort and satisfaction after the surgical removal of mandibular impacted molars using a piezo-electric technique: A randomized double-blind clinical trial 使用压电技术去除下颌阻生磨牙后患者舒适度和满意度的评估:一项随机双盲临床试验。
Journal of oral biology and craniofacial research Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.009
Khalid Zabin Alotaibi , Waleed Mohammed Al Rasheed , Jiingade Krishnojirao Dayashankara Rao , Abdulrahman Altwaijri , Gharam Mefleh Alharbi , Shatha saleh Aljaber
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