Journal of oral biology and craniofacial research最新文献

{"title":"A randomized clinical trial comparing retention of complete dentures and oral health quality of life of patients with conventional and bioelectric impressions","authors":"Sapna Rani,&nbsp;Pankaj Dhawan,&nbsp;Vidushi Saxena","doi":"10.1016/j.jobcr.2024.12.006","DOIUrl":"10.1016/j.jobcr.2024.12.006","url":null,"abstract":"<div><h3>Aim</h3><div>The aim of the present study was to comparatively evaluate the retention of complete dentures and oral health-related quality of life (OHRQoL) of patients with conventional and bioelectric impressions or transcutaneous electric nerve stimulation (TENS).</div></div><div><h3>Materials and methods</h3><div>A total of thirty (n = 30) completely edentulous patients were randomly distributed into two groups: Group-C (n = 15) (Conventional) and Group-T (n = 15) (bioelectric). In Group C, border molding was performed using the manual manipulation of borders, and the final impression was made using zinc-oxide eugenol. In Group T, border molding and final impression were performed with the TENS application. Dentures were fabricated, and retention was evaluated with a digital gauge. OHRQoL was assessed at insertion and after three months of follow-up using the Oral Health Impact Profile Edentulous in Hindi (OHIP-Edent-H) questionnaire. A two-way ANOVA test was used for the significance level (<em>P</em> &lt; 0.05). Student t-test was used for intergroup comparison, and paired <em>t</em>-test was used for intragroup comparison of OHRQoL.</div></div><div><h3>Results</h3><div>There was no significant difference in the retention of maxillary and mandibular dentures fabricated with both techniques (<em>P</em> = 0.283, <em>P</em> = 0.682). Although, OHRQoL increased significantly in both groups at follow-up (<em>P</em> = 0.001). However, at follow-up, the Functional Limitation (FL) domain was significantly better in the conventional group.</div></div><div><h3>Conclusions</h3><div>Although, there was no significant difference in retention and OHRQoL between both groups. However, more clinical trials with large samples and longer follow-ups are required to reach a conclusive result.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 103-107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study","authors":"R. Vijayalakshmi ,&nbsp;N. Ambalavanan ,&nbsp;S. Rajeshkumar ,&nbsp;Jaideep Mahendra ,&nbsp;Uma Sudhakar ,&nbsp;Devi Parameswari","doi":"10.1016/j.jobcr.2024.12.011","DOIUrl":"10.1016/j.jobcr.2024.12.011","url":null,"abstract":"<div><h3>Background</h3><div>This study compared the drug release kinetics of <em>Terminalia arjuna</em> mediated selenium nanoparticles (SeNPs) gel and zinc oxide nanoparticles (ZnONPs) gel for their potential in local drug delivery for chronic periodontitis.</div></div><div><h3>Material and method</h3><div>The drug release was evaluated in-vitro by conducting tests on different formulations, including 1 %, 2 %, 3 %, 4 %, and 5 % <em>Terminalia arjuna</em> mediated SeNPs gel and ZnONPs gel. Each sample, approximately 0.1 mg, was mixed with 10 mL of phosphate buffer saline (PBS) at various pH levels and maintained at 37 °C. The suspension was then placed in an incubated shaker at 120 rpm for 1 h. Five-milliliter samples were withdrawn from the dissolution medium at 30-min intervals and replaced with fresh PBS buffer to maintain a constant volume. The released drug amount was measured using a UV spectrophotometer (Systronics, India) at 290 nm.</div></div><div><h3>Result</h3><div>The investigation revealed that SeNPs gel exhibited higher drug release percentages compared to ZnONPs gel across various concentrations and time points. The sustained release profiles of both formulations suggest effective control over drug release, maintaining therapeutic drug levels over an extended period. The near-complete release of the drug at 500 min highlights the potential for prolonged therapeutic efficacy, reducing the need for frequent dosing and enhancing patient compliance.</div></div><div><h3>Conclusion</h3><div><em>Terminalia arjuna</em> mediated SeNPs gel shows promise for more rapid and sustained drug delivery in the management of chronic periodontitis through local drug delivery systems.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 199-204"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential gene expression profile in Porphyromonas gingivalis treated human gingival keratinocytes and their role in the development of HNSCC","authors":"Dakshinya M ,&nbsp;Anitha P ,&nbsp;A.S. Smiline Girija ,&nbsp;Paramasivam A ,&nbsp;Vijayashree Priyadharsini J","doi":"10.1016/j.jobcr.2024.11.007","DOIUrl":"10.1016/j.jobcr.2024.11.007","url":null,"abstract":"<div><h3>Background</h3><div>Periodontitis is considered to be one of the major risk factors associated with cancers of the oral cavity. Periodontogenic pathogens such as <em>Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Fusobacterium nucleatum</em> and <em>Aggregatibacter actinomycetemcomitans</em> are the important pathogens associated with periodontitis. Chronic exposure to bacterial components induces changes in the nearby cells. Hence, the present study has been designed to identify the molecular mechanisms that could be associated with the two disease conditions <em>viz.,</em> periodontitis and head and neck cancer.</div></div><div><h3>Objective</h3><div>The present study investigated the differential gene expression profile in human gingival keratinocytes treated with <em>P. gingivalis (Pg),</em> a bacterium associated with periodontal disease, and its possible association with the development of Head and Neck Squamous Cell Carcinoma (HNSCC).</div></div><div><h3>Methods</h3><div>The study followed a computational design. Multiple tools and databases, such as GEOmnibus, STRING, Metascape, PANTHER, and UALCAN, cBioportal, were used to derive an association between gene expression during infection with <em>P. gingivalis,</em> and the resulting gene expression profiles were analyzed in the HNSCC dataset.</div></div><div><h3>Results</h3><div>The study revealed 29 genes from a pool of transcripts acquired after comparing the Pg-HIGK and Sham-HIGK. Among them, 3 genes i.e., <em>FST, VRK3,</em> and <em>SGK1,</em> were found to be overexpressed and significantly influenced patient survival. The upregulation of <em>FST</em> was found to correlate with poor prognosis in HNSCC patients.</div></div><div><h3>Conclusion</h3><div>The study provided insights into the possible association of <em>FST, VRK3</em> and <em>SGK1</em> in the development of HNSCC. Further investigations are warranted to confirm the functional role of these genes in establishing the cancer phenotype in patients with chronic infection with <em>Pg</em>.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 48-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials","authors":"Ratri Maya Sitalaksmi ,&nbsp;Rizkipriyanto Azharpratomo ,&nbsp;Shafira Ninditya Irsan ,&nbsp;Primanda Nur Rahmania ,&nbsp;Sisca Meida Wati ,&nbsp;Syafira Salsabila Adam ,&nbsp;Kavanila Bilbalqish ,&nbsp;Khairul Anuar bin Shariff ,&nbsp;Harry Laksono ,&nbsp;Agus Dahlan ,&nbsp;Devi Rianti","doi":"10.1016/j.jobcr.2024.12.002","DOIUrl":"10.1016/j.jobcr.2024.12.002","url":null,"abstract":"<div><h3>Background</h3><div>Tooth extraction without socket preservation will lead to reduction in the dimensions and volume of the alveolar bone. Bone defects resulting from tooth extraction not only hinder prosthetic reconstruction but also present aesthetic issues and complicating dental implant treatment. Purple leaves contains flavonoids, steroids, tannins, saponins,and non-toxic alkaloids. These compounds play roles as antimicrobials, immunomodulators, antioxidants, anti-inflammatories, analgesics. Hydroxyapatite has good biocompatibility, and can induce osteoblast differentiation.</div></div><div><h3>Aim</h3><div>To investigate the effects of the combining nanoemulsion extract of purple leaves and hydroxyapatite on the expression of RUNX2, OSX, OPN, ALP, and calcium deposition.</div></div><div><h3>Method</h3><div>This research used MTT Assay, ICC, and Alizarin Red staining. The study groups were as follows: Group 1: Ad-MSCs; Group 2: Ad-MSCs + αmem; Group 3: Ad-MSCs + osteogenic medium + 1 % nano-extract of Purple leaves &amp; Hydroxyapatite; Group 4: Ad-MSCs + osteogenic medium + 2 % nano-extract of Purple leaves &amp; Hydroxyapatite. Observations were conducted on days 7, 14, and 21.</div></div><div><h3>Results</h3><div>The combination of nanosuspension extract of Purple leaves and hydroxyapatite significantly increased the expression of RUNX2, OSX, OPN,ALP and calcium deposition compared to other groups. The combination of nanoemulsion extract of Purple leaves and hydroxyapatite were significant (P &lt; 0.05) compared to the control group on each day 7, day 14 and day 21.</div></div><div><h3>Conclusion</h3><div>The combination of nanosuspension extract of Purple leaves and hydroxyapatite was able to enhance the expression of RUNX2, OSX, OPN, ALP, and calcium deposition on days 7,14,21.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 63-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical insights on adjustable velar extension and safety mechanism in Tübingen palatal plate for Pierre Robin sequence","authors":"Hemwati Nandan ,&nbsp;Bert Braumann ,&nbsp;Teresa Kruse ,&nbsp;Michael Wolf ,&nbsp;Pragjyoti Jha ,&nbsp;Srinivas Gosla Reddy ,&nbsp;Prasad Nalabothu","doi":"10.1016/j.jobcr.2024.12.021","DOIUrl":"10.1016/j.jobcr.2024.12.021","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 188-190"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers","authors":"","doi":"10.1016/S2212-4268(25)00037-5","DOIUrl":"10.1016/S2212-4268(25)00037-5","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 212-213"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrana preformativa: Unveiling the unexplored facets of dental development","authors":"Sakshi Sikaria,&nbsp;Suganya Panneer Selvam,&nbsp;Ramya Ramadoss,&nbsp;Sandhya Sundar","doi":"10.1016/j.jobcr.2024.12.010","DOIUrl":"10.1016/j.jobcr.2024.12.010","url":null,"abstract":"<div><h3>Aim</h3><div>Odontogenesis is a complex and highly regulated biological process that involves a range of molecular mechanisms. Among these, Ki67 and Cyclin D1 are crucial cell cycle regulators that play pivotal roles in controlling cell proliferation during tooth development. This study aims to provide detailed insights into the expression patterns and functional significance of Ki67 and Cyclin D1 in tooth development. Through rigorous analysis, we seek to elucidate the intricate mechanisms underlying tooth development, helping to advance our understanding of this vital biological process.</div></div><div><h3>Materials &amp; methods</h3><div>The procurement of rabbit tooth germ was performed only after obtaining the requisite ethical clearance. Subsequently, the tissues were processed and subjected to Hematoxylin and Eosin staining to facilitate enhanced visualization of the overall tissue architecture and organization &amp; immunohistochemical staining of Ki-67 and Cyclin D1 was performed.</div></div><div><h3>Results</h3><div>In the tooth germ, cyclin D1 demonstrated intense staining in the dental papilla, especially in the membrana preformativa, with this intensity decreasing following predentin formation. Odontoblasts showed mild staining as they transitioned from pre-odontoblasts, which further diminished after dentin formation. Both the dental papilla and differentiating odontoblasts were positive for Ki67, though Ki67 staining in the odontoblasts reduced after dentin formation.</div></div><div><h3>Conclusion</h3><div>In conclusion, the membrana preformativa plays a key role in odontogenesis, as indicated by its involvement in cellular proliferation and differentiation during tooth development.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 84-87"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and evaluation of screening and self-care (mobile) application for oral and dental problems and emergencies","authors":"Sedighe Sadat Hashemikamangar ,&nbsp;Aidin Sooratgar ,&nbsp;Mina Khayamzadeh ,&nbsp;Shayan Momeni ,&nbsp;Ali Asghar Safaei ,&nbsp;Behnaz Behniafar","doi":"10.1016/j.jobcr.2024.12.016","DOIUrl":"10.1016/j.jobcr.2024.12.016","url":null,"abstract":"<div><h3>Introdution</h3><div>Although oral and dental diseases may occur in unexpected or even emergency conditions, but some of the diagnosis and treatments can be algorithmically done following some guidelines. The development and implementation of a system that provides users with a record of history and a proposal of required actions can be not only efficiently practical, but also virtually simple.</div></div><div><h3>Materials and method</h3><div>A system made up of web and mobile apps is proposed and evaluated for screening and self-care of oral and dental problems and for providing advice on dental emergencies and therapeutic measures. This system was developed and made available to users under the name of 'Dandanyar'. The data were then collected from Dandanyar users and analyzed based on the selected statistical population for evaluating their satisfaction.</div></div><div><h3>Results</h3><div>The evaluation results showed that more than 90 % of specialists had a positive attitude towards application effectiveness. On the other hand, clients expressed their satisfaction with various aspects of the application in more than 80 % of cases.</div></div><div><h3>Conclusion</h3><div>The importance of using such systems is highlighted in the Covid-19 pandemic condition where certain health protocols must be followed. For instance, people must avoid unnecessary traveling and limit their referrals to medical centers especially dental clinics due to the high volume of aerosols produced during dental treatment procedures.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 113-122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illness perception in patients with dental caries: A co-relational study in Odisha","authors":"Hemamalini Rath,&nbsp;Abhijit Panda,&nbsp;Shilpa Mahapatra","doi":"10.1016/j.jobcr.2025.01.003","DOIUrl":"10.1016/j.jobcr.2025.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Illness behaviour refers to any actions or reactions of an individual who feels unwell for defining their state of health and obtaining physical or emotional relief from perceived or actual illness. The present study was conducted to assess illness perception of patients having dental caries using Illness Perceptions Questionnaire-Revised (IPQ-R) in Odisha.</div></div><div><h3>Materials and methods</h3><div>A descriptive co-relational study was conducted among 250 patients with self-reported dental caries in at least one tooth and more than 18 years of age. Data was collected using a cross-culturallyvalidated IPQ-R tool. This was followed by assessment for dental caries using Caries Severity Index. Spearman's correlation and multivariable analysis were conducted.</div></div><div><h3>Results</h3><div>Toothache, visible hole, tooth sensitivity, pain during taking hot and cold food were perceived to be associated with dental caries. Nearly half of the patients had a caries severity score of 5 (pulpitis) or more. Majority (83 %) of participants reported presence of a “visible hole” when they had dental caries. Caries severity was positively correlated with timeline acute/chronic, timeline cyclical and consequence. Significant correlations were noted between IPQ-R components as well.</div></div><div><h3>Conclusion</h3><div>Dental caries was mostly considered to be acute in nature. The study subjects perceived dental caries to have serious consequence, emotionally disturbing symptoms, which they could control by seeking treatment. Further studies need to be conductedwith a larger sample size.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 136-140"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis and systematic review for the genetic basis of cleft lip and palate","authors":"Wafaa Yahia Alghonemy ,&nbsp;Mohamed Gaber Ashmawy","doi":"10.1016/j.jobcr.2024.12.012","DOIUrl":"10.1016/j.jobcr.2024.12.012","url":null,"abstract":"<div><div>Cleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its association with specific genetic polymorphisms. We conducted a meta-analysis and systematic review of seven articles, which provided information on the correlation between genes and NSCL/P risk.</div><div>Our results proved that the MTHFR c.677C &gt; T polymorphism was correlated with the risk of NSCL/P, favoring the control group in the CC genotype and the cases group in the CT genotype. The TT genotype favored the control group. Additionally, the MTHFD1 1958G &gt; A polymorphism was correlated with the high NSCL/P risk in children. However, the MTHFR C677T polymorphism did not show a significant correlation with NSCL/P risk in the analysis, although it was correlated with the high risk in specific populations.</div><div>These results contribute to our knowledge about the genetic causes of NSCL/P and highlight the importance of specific genetic polymorphisms in its development. Further research is needed to explore the genetic mechanisms underlying NSCL/P in different populations and to elucidate its implications for diagnosis, treatment, and prevention strategies.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 146-152"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}