Journal of oral biology and craniofacial research最新文献

{"title":"Evaluation of patient comfort and satisfaction after the surgical removal of mandibular impacted molars using a piezo-electric technique: A randomized double-blind clinical trial","authors":"Khalid Zabin Alotaibi ,&nbsp;Waleed Mohammed Al Rasheed ,&nbsp;Jiingade Krishnojirao Dayashankara Rao ,&nbsp;Abdulrahman Altwaijri ,&nbsp;Gharam Mefleh Alharbi ,&nbsp;Shatha saleh Aljaber","doi":"10.1016/j.jobcr.2024.12.009","DOIUrl":"10.1016/j.jobcr.2024.12.009","url":null,"abstract":"<div><h3>Introduction</h3><div>This is a double clinical trial conducted to study the patient satisfaction and comfort during and after surgical removal of impacted mandibular 3rd molar using Piezo electric tips.</div></div><div><h3>Material and methods</h3><div>Two groups of 25 each [14 (56 %) males and 11 (44 %) females] and [18 (72 % males and 07 (28 %) females] represented the Rotary and Piezo groups respectively with bilateral impactions. one side of the patient is operated by piezo and the other side by rotary instrument after a gap of 2–3 week between the procedures. The variables considered are pain, swelling, trismus, patient satisfaction and comfort. The readings were taken on base line,3rd day,7th and 14th day.</div></div><div><h3>Results</h3><div>Descriptive statistical analysis was performed using means and standard deviations for continuous variables and percentages for categorical variables. The level of significance was set at p &lt; 0.05. The surgery time taken was more in the Piezo group (26.96 ± 12.201) in comparison with the Rotary group (21.32 ± 12.786- (p = 0.011∗). Satisfaction was rated better in the Piezo group (3.18 ± 0.909 vs 2.88 ± 0.881) (p = 0.013∗). Tactile sensation was less in the Piezo group (1.24 ± 0.436) vs (2.28 ± 0.678) (p = 0.001). Less pain was reported in the piezo group patients and the difference between the two groups was statistically significant only during the third day follow up (p = 0.001).</div></div><div><h3>Conclusion</h3><div>The overall patient satisfaction and comfort was better in piezo in spite of longer duration of surgery. It provides better quality of life as the patients experienced less pain and the total number of analgesics taken is significantly less compared to rotary group.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 108-112"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats","authors":"Ananto Ali Alhasyimi ,&nbsp;Niswati Fathmah Rosyida ,&nbsp;Ika Dewi Ana","doi":"10.1016/j.jobcr.2024.12.013","DOIUrl":"10.1016/j.jobcr.2024.12.013","url":null,"abstract":"<div><h3>Background</h3><div>Retention is an essential element of orthodontic treatment. In the past two decades, numerous biological treatments have been developed to alleviate orthodontic relapse. Pharmacologic bone modulation is a viable approach to mitigate relapse. The aim of this investigation was to determine whether administering nanoemulsion carbonated hydroxyapatite-statin (CHA-statin) would increase Runx-2 expression and decrease Acp 5 expression in rats experiencing experimental orthodontic relapse.</div></div><div><h3>Materials &amp; methods</h3><div>Forty-eight rats (n = 48) were assigned to four groups: control, CHA, statin, and CHA-statin, with 12 rats in each group. A 30 g mesial traction was applied for 7 days via a closed-coil spring that connected the first maxillary molar to the maxillary incisor. To maintain the moved teeth, CHA, statin hydrogel, and nanoemulsion CHA-statin were administered intrasulcularly every 3 days for a period of 7 days. The removal of the devices facilitated the occurrence of relapse. The expression of Acp 5 and Runx-2 was evaluated using the immunohistochemistry method. The collected data were evaluated using analysis of variance and post hoc tests, with <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>A significant reduction in Acp 5-positive cells in the CHA-statin group was observed on days 7 and 14 of relapse movement compared with the other groups (<em>p</em> &lt; 0.05), whereas the average Runx-2 expressions in the CHA-statin groups were significantly higher than in the other groups on days 1, 7, and 14 during the relapse phase (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The nanoemulsion CHA-statin increased Runx-2 expression and decreased Acp 5 expression, thereby potentially preventing orthodontic relapse in rats.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 129-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of viability, proliferation, and mineralization potential of human pulp and osteoblastic cells exposed to different bioceramic endodontic sealers","authors":"Marcos Coelho Santiago ,&nbsp;Gustavo Henrique de Oliveira Salles ,&nbsp;Gustavo Gomes de Lima ,&nbsp;Laudimar Alves de Oliveira ,&nbsp;Loise Pedrosa Salles","doi":"10.1016/j.jobcr.2025.01.008","DOIUrl":"10.1016/j.jobcr.2025.01.008","url":null,"abstract":"<div><h3>Background</h3><div>The present study aimed to compare the viability, proliferation, and mineralization potential of human dental pulp cells (hDPCs) and osteoblasts cell line (Saos-2) after exposure to AH Plus® Bioceramic (AHP-B), Bio-C® Sealer (BIO-C), NeoMTA Plus® (NEOMTA-P), and MTA-FILLAPEX® endodontic sealers (MTA-F).</div></div><div><h3>Methods</h3><div>All materials were prepared according to the manufacturer's instructions. Before exposing the cells, we measured the release of calcium ions (Ca²⁺) from the dental materials to the culture media once Ca²⁺ can trigger signaling pathways. After that, hDPCs and Saos-2 were exposed to the sealers for MTT assay to assess the cell viability and wound healing to evaluate the cell proliferation. To investigate the potential of mineralization, we assessed the alkaline phosphatase activity and calcium deposition by Alizarin red staining. Statistical analysis was performed using Two-way ANOVA for calcium release and wound healing assays and One-way ANOVA for other assays, with post-test Bonferroni correction. The results were significant when p &lt; 0.05.</div></div><div><h3>Results</h3><div>The sealers released diverse concentrations of calcium at different times. The hDPCs viability and proliferation were low in the AHP-B group at 24h of exposure (NEOMTA-P ∼ BIO-C ∼ CT &gt; AHP-B &gt; MTA-F), distinct from the osteoblastic cells (NEOMTA-P ∼ AHP-B ∼ CT &gt; BIO-C &gt; MTA-F) and (proliferation: AHP-B &gt; NEOMTA-P ∼ CT &gt; BIO-C &gt; MTA-F). The ALP activity, an early marker of osteogenesis, was higher in hDPCs exposed to NEOMTA-P, while the osteoblastic cells showed higher ALP when exposed to AHP-B.</div></div><div><h3>Conclusion</h3><div>AHP-B, NEOMTA-P, and BIO-C stimulated osteogenesis in hDPCs and Saos-2 cells, with marked differences between groups. AHP-B showed an improved early stimulation of osteoblastic cells, while hDPCs were more responsive to NEOMTA-P.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 191-198"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive characterization of tobacco-induced changes in enamel surface topography","authors":"Tamanna Kaur ,&nbsp;Ramya Ramadoss ,&nbsp;Nitya Krishnasamy ,&nbsp;Sandhya Sundar ,&nbsp;Suganya Panneer Selvam ,&nbsp;Hema Shree K","doi":"10.1016/j.jobcr.2024.12.007","DOIUrl":"10.1016/j.jobcr.2024.12.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Enamel translucency, essential for the aesthetic appeal of teeth, is primarily determined by its thickness, quality, and refractive index. Several factors, including age, genetics, diet, oral hygiene practices, fluoride exposure, and acidic challenges, can influence enamel translucency. Tobacco use, in particular, leads to significant alterations in enamel appearance by penetrating its micropores, causing yellowing and browning. Prolonged exposure to tobacco results in demineralization, increasing enamel porosity and reducing its translucency. Over time, this exposure leads to permanent discoloration and structural degradation, rendering teeth dull and opaque. To assess these changes, various methods such as visual examinations, digital photography, spectrophotometry, stylus profilometry, and atomic force microscopy (AFM) are utilized.</div></div><div><h3>Materials and methods</h3><div>This study analyzed human enamel samples, including one unstained sample (Grade 0) and three tobacco-stained samples (Grades 1–3) according to Modified Lobene Stain Index (MLSI), to investigate the impact of tobacco exposure on enamel structure. The samples were thoroughly cleaned and dried to ensure accurate results. High-resolution AFM imaging was employed to assess surface roughness, porosity, and microstructural changes induced by tobacco staining. A stylus profilometer was used to trace the surface topography, providing detailed measurements of surface irregularities. Additionally, a spectrophotometer was utilized to evaluate the optical properties of the enamel, focusing on changes in translucency and light absorption due to tobacco exposure.</div></div><div><h3>Results</h3><div>AFM analysis revealed a clear progression of enamel surface roughness from Grade 0 to Grade 3. The Sa and Sq values increased significantly with the severity of tobacco staining, indicating greater surface degradation. The stylus profilometer data corroborated these findings, with rising Ra values as the degree of staining intensified, highlighting the topographical alterations caused by tobacco exposure. Spectrophotometric analysis further demonstrated a decrease in enamel reflectance and an increase in light absorption from mild to severe staining, underscoring the detrimental optical effects of tobacco on enamel.</div></div><div><h3>Conclusion</h3><div>The combined use of AFM, stylus profilometry, and spectrophotometry provided a comprehensive assessment of the impact of tobacco staining on enamel translucency and surface roughness. The findings show that as staining severity increases, enamel translucency diminishes, and surface roughness worsens. These alterations not only affect the aesthetic appearance of teeth but also have potential implications for enamel functionality and long-term oral health.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 97-102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Styloid process phenotype and atheromatous plaque: Radiographic and bone density assessment in parathyroid disease","authors":"Adilia Mirela Pereira Lima Cid ,&nbsp;Davi de Sá Cavalcante ,&nbsp;Marcela Lima Gurgel ,&nbsp;Ana Carolina Saraiva ,&nbsp;Ana Alicia Sales Ricardo ,&nbsp;Lúcio Mitsuo Kurita ,&nbsp;Paulo Goberlânio de Barros Silva ,&nbsp;Catarina Brasil d’Alva ,&nbsp;Ana Rosa Pinto Quidute ,&nbsp;Fabio Wildson Gurgel Costa","doi":"10.1016/j.jobcr.2024.12.001","DOIUrl":"10.1016/j.jobcr.2024.12.001","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to assess the styloid process (TBSP) phenotype and to identify suggestive images of calcified atheromatous plaques (CAP) in panoramic radiographs of patients with primary hyperparathyroidism (PHPT) and post-surgical hypoparathyroidism (hypoPT). Additionally, it aimed to analyze the association between the bone mineral status of patients with parathyroid diseases and the radiographic findings.</div></div><div><h3>Material and methods</h3><div>A cross-sectional case-control study was conducted with individuals diagnosed with PHPT (n = 25) and post-surgical hypoPT (n = 25). A control group (n = 50) comprised individuals without parathyroid gland disorders. Panoramic radiographs were utilized for both quantitative (length) and qualitative (mineralization patterns) evaluation of the TBSP, as well as for assessing the prevalence of CAP.</div></div><div><h3>Results</h3><div>The frequency of TBSP exceeding 30 mm was significantly higher in the PHPT and post-surgical hypoPT groups compared to the control group. CAP occurred more frequently in the PHPT group. Cases of low bone mineral density (BMD) were associated with PHPT. In the PHPT group, low BMD was linked to an increased average TBSP length (p = 0.025) and a higher frequency of elongated TBSP (p = 0.022). Multivariate analysis revealed an inverse relationship between the T-score of the femoral neck and TBSP length in the PHPT group (p = 0.028).</div></div><div><h3>Conclusions</h3><div>Compared to the control group, individuals with PHPT and post-surgical hypoPT showed distinct imaging findings related to TBSP and CAP. Individuals with PHPT and low BMD showed a higher frequency of elongated TBSP.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 88-96"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Third molar infections and their impact on systemic health- an awareness study among women degree college students of Udupi City, Karnataka, India","authors":"Ananya Prabhu ,&nbsp;Ramprasad Vasthare ,&nbsp;Prajna P. Nayak ,&nbsp;Gargi Gandhi ,&nbsp;Shreyosi Banik ,&nbsp;Bidisha Sarmah","doi":"10.1016/j.jobcr.2025.01.002","DOIUrl":"10.1016/j.jobcr.2025.01.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The wisdom teeth usually erupt at the age of 17–25 years leading to the risk of pericoronitis, caries, periodontitis, anterior crowding of teeth and cyst development. Previous studies have reported that the third molar infection is more associated with the age group of 26–35 years and is more commonly reported in the female gender.</div></div><div><h3>Aims</h3><div>Hence, the aim was to assess knowledge regarding third molar infections among women degree college students.</div></div><div><h3>Method</h3><div>ology: This cross-sectional study was conducted among 600 students in three women's degree colleges. Awareness and oral health practices were recorded using a supervised self-administered structured questionnaire. The third molar status was recorded by two calibrated examiners. Descriptive statistics, ANOVA, independent T-test and chi-square tests were used to interpret the data.</div></div><div><h3>Results</h3><div>The prevalence of dental caries and pericoronitis with respect to the third molar was 22.5 % and 10.5 % respectively. 63 % expressed no awareness regarding problems associated with third molars. Only 27.2 % were aware of the impact of third molar infection on general health. Mean awareness score was 3.22 ± 1.60. There was a significant increase in awareness of third molars with age. Presence of dental caries significantly affects knowledge score, with those having dental caries (3.68) having a higher score.</div></div><div><h3>Conclusion</h3><div>This study emphasizes the importance of comprehensive oral health education programs tailored to the needs of students in different educational institutions. By raising awareness about third-molar-related complications and promoting regular dental check-ups, these programs can contribute to improving oral health outcomes among young adults.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 141-145"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial activity of 1 % Roselle flower nano-emulsion extract (Hibiscus sabdariffa) against peri-implantitis-related bacteria on orthodontic mini-implants: An in vitro study","authors":"Ridhofar Akbar Khusnul Abdillah ,&nbsp;Theresia Indah Budhy ,&nbsp;Ida Bagus Narmada ,&nbsp;I Gusti Aju Wahju Ardani ,&nbsp;Nastiti Faradilla Ramadhani ,&nbsp;Ratri Maya Sitalaksmi ,&nbsp;Muhammad Luthfi ,&nbsp;Ninik Mas Ulfa ,&nbsp;Albertus Putera Nugraha ,&nbsp;Tengku Natasha Eleena binti Tengku Ahmad Noor ,&nbsp;Alexander Patera Nugraha","doi":"10.1016/j.jobcr.2024.12.017","DOIUrl":"10.1016/j.jobcr.2024.12.017","url":null,"abstract":"<div><h3>Objective</h3><div>The orthodontic mini-implant (OMI) failure often occurs due to the accumulation of peri-implantitis bacteria surrounding it, which results in a stable, resistant form of absolute skeletal anchorage during orthodontic treatment. Administering doxycycline may be the solution, but long-term side effects result in antibiotic resistance. Roselle flowers (Hibiscus sabdariffa) possess beneficial active phytochemical substances, which may have potential as an OMI peri-implantitis alternative therapy. This study investigates the antibacterial activity of 1 % Roselle flower (H. sabdarifa) nanoemulsion (NE) extract (1 % RNE) toward peri-implantitis bacteria in OMIs.</div></div><div><h3>Methods</h3><div>A phytochemical analysis of 1 % RNE was carried out to examine the active substances possessed in it, such as flavonoids, quinone, saponin, alkaloids, tannins, terpenoids, and steroids. Nanoemulsion characterization was carried out using a particle size analyzer (PSA). The antibacterial activity of 1 % RNE toward Prevotella intermedia (Pi), Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), and Fusobacterium nucleatum (Fn) was carried out to determine the minimum inhibitory concentration, minimum bactericidal concentration, and inhibitory zone compared with doxycycline as a positive control.</div></div><div><h3>Results</h3><div>Roselle flower NE extract (1 %) possessed flavonoids, quinone, saponin, alkaloids, tannins, terpenoids, and steroids positively. The PSA showed that the 1 % RNE had a size of 98.13 d nm. The antibacterial activity of 1 % RNE against Aa, Pg, Pi, and Fn bacteria at 3.125 % showed significant differences (p &lt; 0.05). The antibacterial activity of 1 % RNE toward peri-implantitis bacteria is lower than that of doxycycline.</div></div><div><h3>Conclusion</h3><div>Roselle flower NE extract (1 %) has antibacterial activity against peri-implantitis bacteria at a concentration of 3.125 %.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 170-177"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study","authors":"Monika M ,&nbsp;Rudhra K ,&nbsp;Vennila K ,&nbsp;Elanchezhiyan ,&nbsp;Sri Harini P ,&nbsp;S. Shakeron","doi":"10.1016/j.jobcr.2025.01.004","DOIUrl":"10.1016/j.jobcr.2025.01.004","url":null,"abstract":"<div><h3>Background and objective</h3><div>Periodontitis and dental caries are among the most prevalent oral diseases, with chronic periodontitis being a multifactorial, infectious condition that leads to inflammation in the supporting structures of the teeth, progressive attachment loss, and bone resorption. Chronic periodontitis is driven by a consortium of pathogenic microorganisms. This study aimed to evaluate the efficacy of virgin coconut oil (VCO) pulling in reducing the microbial load and inflammatory mediators responsible for chronic periodontitis, in comparison to chlorhexidine (CHX) mouthwash and distilled water.</div></div><div><h3>Methods</h3><div>Thirty patients diagnosed with chronic periodontitis were randomly allocated into three groups. Group A served as the control and used distilled water for oral rinsing, Group B used chlorhexidine mouthwash, and Group C performed oil pulling with virgin coconut oil. Pre-operative subgingival plaque samples were collected from all participants, followed by complete scaling and root planing. Post-operative samples were collected after four weeks. Both pre- and post-treatment samples were subjected to real-time PCR (rtPCR) and enzyme-linked immunosorbent assay (ELISA) to quantify viral and bacterial loads, as well as levels of key inflammatory mediators.</div></div><div><h3>Results</h3><div>A significant reduction in viral load, bacterial load, and inflammatory mediators was observed in both the VCO and CHX groups compared to the distilled water group. The reductions in the VCO and CHX groups were statistically significant, with comparable efficacy between the two interventions.</div></div><div><h3>Conclusion</h3><div>Virgin coconut oil pulling demonstrated a significant reduction in microbial and inflammatory markers in patients with chronic periodontitis, showing similar efficacy to chlorhexidine mouthwash. Given its comparable therapeutic effects and reduced side effect profile, VCO presents a viable alternative to chlorhexidine for managing chronic periodontitis.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 153-158"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative in-vitro degradation of hyaluronic acids exposed to different hyaluronidase enzymes","authors":"Marcelo Germani ,&nbsp;Márcia V.G.B. de Queiroz ,&nbsp;Mariana Yuri de França Shimizu ,&nbsp;Thiago Gomes Teixeira ,&nbsp;Victor Rogerio ,&nbsp;Gabriela Giro ,&nbsp;Victor R.M. Munoz-Lora","doi":"10.1016/j.jobcr.2025.01.001","DOIUrl":"10.1016/j.jobcr.2025.01.001","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to compare the in-vitro behavior of four Hyaluronic acid (HA) gels when exposed to two different hyaluronidase (HSE) formulations.</div></div><div><h3>Methods</h3><div>Four commercially available HA were used: Lyft (Lt; Restylane, Galderma, Sweden), Voluma (Vol; Allergan, AbbVie, USA), UltraDeep (UDe; Rennova, Innovapharma, Brazil), and Subskin (Skn; Perfectha, Sinclair, France). The gels were divided into two groups, with seven aliquots (0.1 mL per aliquot) for each group deposited on a glass plate. A millimeter ruler was positioned behind the plate to measure the gel height. Each aliquot received 100 UTR of one of two HSE formulations. After 2 min, each aliquot was mixed using a 22G needle and left to sit for additional 2 min.</div></div><div><h3>Results</h3><div>Partial and final degradation of the products were obtained through photographic analysis. The final percentage of degradation exhibited significant differences among HA gels (P &lt; 0.001). The results revealed higher degradation in Lt, moderate degradation in UDe, and lower degradation in Vol and Skn. Comparisons of HSE formulations showed no significant differences among them (P = 0.881). Moreover, there was a noticeable degradation after mixing (P &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Within the limits of this study, it can be suggested that Lt exhibits the higher degradation among the experimented gels. Furthermore, differences among HSE formulations do not appear to significantly impact HA degradation, while the mixing movement of HSE and HA seems to influence the degradation rate. These findings may help guide clinical decisions regarding the use of hyaluronidase in managing HA filler complications or adjustments.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 178-182"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric analysis of 100 most cited papers on oral proliferative verrucous leukoplakia","authors":"Namrata Sengupta ,&nbsp;Gargi S. Sarode ,&nbsp;Sachin C. Sarode","doi":"10.1016/j.jobcr.2024.11.008","DOIUrl":"10.1016/j.jobcr.2024.11.008","url":null,"abstract":"<div><h3>Background</h3><div>Bibliometric analysis of highly cited papers in a particular discipline brings forward the impactful papers published, the significant journals and the researchers in the field. These studies help in identifying research trends and research lacunae in the field, thus guiding the future research works. Oral proliferative verrucous leukoplakia (OPVL) is a challenging lesion with no uniform diagnostic criteria. Thus, bibliometric analysis of published papers in this field will help researchers and clinicians to get an overview of the research trends and the research lacunae associated with OPVL.</div></div><div><h3>Method</h3><div>A search was done with help of Scopus database in November 2023. The articles on OPVL were retrieved and reviewed thoroughly. The bibliometric data was also recorded.</div></div><div><h3>Results</h3><div>The impactful research papers were published in the time span of 1985–2022 with maximum output being in the decade 2011–2020. The highest citation received was 297 and the least was 4 (mean citations 34 ± 42.57). These papers were published in 47 different journals. Seven authors contributed 5 or more papers each. United States had the major contribution of papers (n = 28). There were 71 articles and 18 review papers in the top list.</div></div><div><h3>Conclusion</h3><div>This bibliometric and citation analysis of OPVL research papers will guide researchers and clinicians in understanding the research traits and thus, may help in making OPVL a less challenging lesion.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 41-47"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}