Journal of oral biology and craniofacial research最新文献

{"title":"Economic burden and economic impact of oral diseases in India: A systematic review and meta-analysis","authors":"Vineetha Karuveettil ,&nbsp;Chandrashekar Janakiram ,&nbsp;Aparna Ramachandran ,&nbsp;Denny John","doi":"10.1016/j.jobcr.2026.01.006","DOIUrl":"10.1016/j.jobcr.2026.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>To quantify the economic burden and financial impact of oral diseases in India—on individuals, households, the health system, and society—focusing on direct and indirect costs and out-of-pocket expenditure (OOPE).</div></div><div><h3>Methods</h3><div>Following JBI methodology and PRISMA 2020, we conducted a three-step search of MEDLINE, Embase, Scopus, CINAHL, DOSS, Cochrane CENTRAL, and grey literature. We included India-based studies reporting economic burden/financial impact at individual, household, or population levels. Eligible designs were cost-of-illness, cost/expenditure analyses, and cohort or cross-sectional studies; mixed-methods with extractable quantitative data were included. Two reviewers independently screened, appraised (JBI tools), and extracted data on direct/indirect costs, OOPE, catastrophic expenditure (CHE), and hardship financing. Findings were narratively synthesized; meta-analysis was undertaken in JBI SUMARI where appropriate.</div></div><div><h3>Results</h3><div>Of 1684 records, 15 met inclusion criteria, mostly cross-sectional across states. OOPE varied widely; oral-cancer treatment often ranged from INR 80,000 to over INR 2,30,000. Direct costs were higher in private settings; indirect productivity losses were reported. CHE ranged from 0.6 % to 96 % across definitions; pooling studies using the ≥20 % income threshold yielded a CHE prevalence of 18.8 %. Insurance coverage was low (&lt;15 %) with limited protection. Up to one-third of patients relied on hardship financing (borrowing or asset sales).</div></div><div><h3>Conclusion</h3><div>Oral diseases impose a substantial economic burden in India, characterised by high OOPE, elevated CHE risk (pooled 18.8 %), and frequent distress financing. Priorities include stronger national data, standardised costing/reporting (price year, components, variance), and expanded financial protection to reduce household hardship and advance universal oral health coverage.</div></div><div><h3>Systematic review registration number</h3><div>The protocol is prospectively registered in the International Prospective Register of Systematic Reviews database (PROSPERO ID: CRD420251030651).</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101402"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing graphene-enhanced polycaprolactone scaffolds for bone tissue engineering","authors":"Silvia Anitasari ,&nbsp;Nataniel Tandirogang ,&nbsp;Hadi Irawiraman ,&nbsp;Hendrik Setia Budi ,&nbsp;Yung-Kang Shen ,&nbsp;Levi Natya Alus ,&nbsp;Prawati Nuraini","doi":"10.1016/j.jobcr.2026.101418","DOIUrl":"10.1016/j.jobcr.2026.101418","url":null,"abstract":"<div><h3>Background</h3><div>Polycaprolactone (PCL) is widely used in scaffold fabrication due to its biocompatibility and mechanical properties, yet its limited osteoinductive capability hinders effective bone regeneration. To address this, graphene (G) has been incorporated into PCL scaffolds to enhance bioactivity, mechanical strength, and osteogenic potential.</div></div><div><h3>Objective</h3><div>This study evaluates the osteogenic efficacy of PCL/G composite scaffolds by analyzing osteocalcin (OCN) and osteopontin (OPN) expression and mineralization using Alizarin Red staining.</div></div><div><h3>Methods</h3><div>Thirty-six adult male rabbits were randomized to four groups and evaluated on day 7, 14 and 21. The PCL/G scaffolds were fabricated using the solvent casting and particle leaching method. A left tibial incision was made and exposing the site for osteotomy. Scaffolds were implanted, and wounds closed. Expression of OCN and OPN were evaluated by immunochemistry and mineralization was evaluated by Alizarin Red staining.</div></div><div><h3>Results</h3><div>The results indicate that increasing graphene concentration significantly enhances osteogenic activity, with 2.5 wt% graphene demonstrating the highest OCN and OPN expression, as well as superior calcium deposition.</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential of graphene-based scaffolds in promoting bone regeneration and accelerating clinical translation. Future research should focus on long-term in vivo studies and scaffold degradation kinetics to validate their effectiveness in maxillofacial bone defects due to oral cancer surgery.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101418"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical translation of 3D bioprinting in oral and maxillofacial reconstruction: Recent progress and future directions","authors":"Shantanu Dixit ,&nbsp;Maher AL. Shayeb ,&nbsp;Goma Kathayat ,&nbsp;Dinesh Rokaya","doi":"10.1016/j.jobcr.2026.01.005","DOIUrl":"10.1016/j.jobcr.2026.01.005","url":null,"abstract":"<div><h3>Background</h3><div>Oral and maxillofacial reconstruction (OMF) requires regeneration of bone, soft tissue, vasculature, and nerves. Three-dimensional (3D) bioprinting offers a paradigm shift, enabling fabrication of patient-specific, cell-laden constructs designed to restore both anatomical form and biological function. This review presents an updated review on the clinical translation of 3D bioprinting in oral and maxillofacial reconstruction and presents future directions.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for studies published up to June 2025, using search terms such as “3D bioprinting,” “bioink,” “OMF reconstruction,” and tissue-specific phrases. Extracted data addressed bioprinting strategies, biomaterials, and outcomes, which were synthesized into translational phases and tissue-specific applications.</div></div><div><h3>Results</h3><div>Four phases of translational progress were identified: (1) in vitro validation of bioinks and cell viability; (2) small-animal studies demonstrating osteogenesis, angiogenesis, and pulp–periodontal regeneration; (3) large-animal models addressing anatomical scalability and achieving partial functional integration; and (4) early human applications of acellular, patient-specific scaffolds. Success depends on tailoring bioinks—integrating stem cells, biomaterials, and signaling molecules—for tissues such as vascularized pulp, mineralized bone, and the periodontal ligament interface.</div></div><div><h3>Conclusion</h3><div>3D bioprinting holds transformative potential for OMF reconstruction. While progress is evident from bench to large-animal studies, clinical adoption of viable, cell-laden constructs remains elusive. Overcoming biofabrication, integration, and regulatory challenges through interdisciplinary collaboration will be critical to realize the promise of patient-specific, functional bioprinted OMF tissues in clinical practice.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101401"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical resolution of oral lichenoid lesions after amalgam replacement: A systematic review and meta-analysis of observational studies","authors":"Harshita Kothari ,&nbsp;Ajinkya M. Pawar ,&nbsp;Pankaj Gupta ,&nbsp;Alexander Maniangat Luke ,&nbsp;Mohamed Saleh Hamad Ingafou ,&nbsp;Parmeet Banga ,&nbsp;Mohmed Isaqali Karobari ,&nbsp;Dian Agustin Wahjuningrum","doi":"10.1016/j.jobcr.2026.01.008","DOIUrl":"10.1016/j.jobcr.2026.01.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Oral lichenoid lesions (OLLs) can mimic oral lichen planus but are often linked to contact with dental amalgam. Replacement with biocompatible materials has been associated with lesion resolution, yet prior evidence lacked quantitative synthesis.</div></div><div><h3>Materials and methods</h3><div>Following PRISMA 2020 (PROSPERO: CRDXXXXXXXXXX2), eight databases (1986–2024) were searched for adult in vivo studies reporting OLL resolution after amalgam replacement. Two reviewers independently screened, extracted data, and assessed bias (ROBINS-I, Newcastle–Ottawa Scale, JBI). Random-effects meta-analysis estimated pooled odds ratios (OR) for clinical resolution; certainty was graded with GRADE.</div></div><div><h3>Results</h3><div>Of 2368 records, 35 studies were qualitatively synthesized and 11 entered meta-analysis (N = 365). Amalgam was replaced with glass ionomer, ceramics, composite resin, or gold alloys. Replacement markedly increased odds of lesion resolution (OR = 122.18; 95 % CI: 55.64–268.26; p &lt; 0.001) with moderate heterogeneity (I² = 42 %). Risk of bias across observational studies was generally low to moderate. Funnel-plot asymmetry and Egger's test (p &lt; 0.001) suggested publication bias; overall certainty was moderate. Subgroup analyses indicated greater benefit when lesions had direct amalgam contact, when patch testing was positive, and when ceramics or gold were used. Sensitivity analyses supported strength of the primary findings.</div></div><div><h3>Conclusion</h3><div>Amalgam replacement was linked with substantially higher odds of OLL resolution. However, between-study heterogeneity and indications of publication bias temper confidence in the pooled effect. Confirmatory, prospective, registered studies with standardized diagnostic criteria, outcome definitions, and material categories are needed to refine effect size estimates and strengthen certainty.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101404"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUC-MSC secretome and Nanoemulsion Propolis synergistically modulate inflammatory responses in hyperglycemia-induced calvarial osteolysis","authors":"Putri Cahaya Situmorang ,&nbsp;Helen Helen ,&nbsp;Syafruddin Ilyas ,&nbsp;Salomo Hutahaean ,&nbsp;Doni Aldo Samuel Siahaan ,&nbsp;Ananto Ali Alhasyimi ,&nbsp;Muh Ade Artasasta ,&nbsp;Wibi Riawan ,&nbsp;Khairul Anuar Shariff ,&nbsp;Alexander Patera Nugraha","doi":"10.1016/j.jobcr.2026.101430","DOIUrl":"10.1016/j.jobcr.2026.101430","url":null,"abstract":"<div><h3>Background</h3><div>Hyperglycemia-induced osteolysis is a significant consequence of diabetes mellitus, marked by heightened inflammatory responses, augmented osteoclastogenesis, and compromised osteoblast function. Innovative therapy approaches aimed at inflammatory and cytoprotective mechanisms are essential to avert diabetic bone loss.</div></div><div><h3>Objective</h3><div>This study investigated the synergistic effects of human umbilical cord mesenchymal stem cell (HUC-MSC) secretome and Nanoemulsion Propolis (NEP) on inflammatory responses and protective protein expression in a rat model of hyperglycemia-associated calvarial osteolysis.</div></div><div><h3>Methods</h3><div>Male Wistar rats were categorized into seven groups: control, LPS-induced inflammation, hyperglycemia, a combination of LPS and hyperglycemia, and treatment groups administered HUC-MSC secretome, NEP, or both. Cytokine concentrations (IL-1β, TNF-α, IL-10) were measured using ELISA, whilst NF-κB, IL-6, HSP-70, and HSP-10 expression in calvarial tissue was assessed by immunohistochemistry.</div></div><div><h3>Results</h3><div>LPS, in conjunction with hyperglycemia, significantly increased pro-inflammatory cytokines and NF-κB activation, reduced IL-10 levels, and inhibited HSP-70 and HSP-10, hence worsening bone resorption. Treatment with HUC-MSC secretome or NEP alone moderately diminished inflammation, however the combined therapy markedly downregulated NF-κB, IL-1β, TNF-α, and IL-6, while reinstating IL-10 and stress proteins. These modifications diminished osteoclast activation and maintained osteoblast viability, with the most significant protective impact noted in the combination group.</div></div><div><h3>Conclusion</h3><div>The HUC-MSC secretome and NEP collaboratively influence inflammatory pathways and reinstate protective proteins in calvarial osteolysis triggered by hyperglycemia. This dual technique presents a promising acellular and natural product-based method for addressing diabetes bone loss and associated craniofacial problems.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101430"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147398684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial impact of chronic oral mucosal pain disorders: Associations with oral health related quality of life, anxiety, and depression","authors":"Nancy Jidiya ,&nbsp;Anulatha Manne ,&nbsp;Sravanthi Ennala ,&nbsp;Krishnapuram Akshita ,&nbsp;Dhanashree Kamble ,&nbsp;Riya Anand ,&nbsp;Isha Patel ,&nbsp;Santosh R. Patil ,&nbsp;Shikhar Daniel","doi":"10.1016/j.jobcr.2026.101426","DOIUrl":"10.1016/j.jobcr.2026.101426","url":null,"abstract":"<div><h3>Background</h3><div>Chronic oral mucosal pain disorders, including Burning Mouth Syndrome (BMS), Oral Lichen Planus (OLP), Atypical Odontalgia, and Persistent Idiopathic Facial Pain, are debilitating conditions that significantly impair oral health–related quality of life (OHRQoL). These disorders are frequently associated with psychological distress, particularly anxiety and depression; however, studies integrating assessments of OHRQoL with psychological morbidity remain limited.</div></div><div><h3>Objective</h3><div>To evaluate the impact of chronic oral mucosal pain disorders on OHRQoL, anxiety, and depression, and to identify psychological predictors of impaired quality of life.</div></div><div><h3>Methods</h3><div>A case–control study was conducted involving 52 patients with chronic oral mucosal pain disorders and 52 age- and sex-matched healthy controls. OHRQoL was assessed using the Oral Health Impact Profile–14 (OHIP-14), and psychological distress was measured using the Hospital Anxiety and Depression Scale (HADS). Group comparisons were performed using independent t-tests and chi-square tests. Multivariable linear regression identified independent predictors of OHIP-14 scores, and receiver operating characteristic (ROC) analysis evaluated the ability of OHIP-14 to detect depression.</div></div><div><h3>Results</h3><div>Patients showed significantly higher OHIP-14 scores than controls (28.3 ± 6.0 vs. 11.7 ± 5.0; p &lt; 0.0001). Clinically relevant anxiety and depression were present in 84.6% and 80.8% of patients, respectively. Anxiety and depression independently predicted poorer OHRQoL, while demographic factors and symptom duration were not significant. OHIP-14 demonstrated good diagnostic accuracy for depression (Area under the curve (AUC) = 0.85).</div></div><div><h3>Conclusion</h3><div>Chronic oral mucosal pain disorders (COMPD) are associated with marked impairment in quality of life and substantial psychological burden, underscoring the need for routine psychological screening in oral medicine practice.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101426"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147398683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding the ultimate truth: What role remains for systematic reviews and meta-analysis?","authors":"Vidya Rattan (Editor-in-Chief),&nbsp;Ashok Kumar Jena (Section Editor (Orthodontics))","doi":"10.1016/j.jobcr.2026.101415","DOIUrl":"10.1016/j.jobcr.2026.101415","url":null,"abstract":"","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101415"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E-cigarette aerosol exposure drives extracellular matrix gene dysregulation and collagen remodeling in gingival fibroblasts: An in vitro study","authors":"Padmanathan Ramasamy ,&nbsp;Karthikeyan Kandaswamy ,&nbsp;R. Navaneethan ,&nbsp;Raghunandhakumar Subramanian","doi":"10.1016/j.jobcr.2026.101428","DOIUrl":"10.1016/j.jobcr.2026.101428","url":null,"abstract":"<div><h3>Background</h3><div>E-cigarettes are promoted as less harmful alternatives to traditional tobacco products; however, their effects on periodontal tissues and orthodontic outcomes remain unexplored. This study aimed to investigate the impact of e-cigarette aerosol extract (ECAE) on human gingival fibroblasts (hGFs), focusing on cell viability, extracellular matrix (ECM) integrity, gene expression, and nicotine–protein interactions.</div></div><div><h3>Methods</h3><div>Primary hGFs were exposed to ECAE (5–100%) prepared using a standardized puffing protocol. Cell viability was assessed at 24 and 72 h using the MTT assay. ECM-related gene expression with COL1A1, MMP1, MMP9, TIMP1 was quantified by qPCR. Collagen matrix organization and cellular morphology were evaluated using Masson's Trichrome staining and phase-contrast microscopy. Molecular docking was performed to assess nicotine interactions with ECM-associated proteins in 2D and 3D structures.</div></div><div><h3>Results</h3><div>ECAE exposure resulted in a concentration- and time-dependent reduction in fibroblast viability, with significant cytotoxicity observed at concentrations ≥25%. qPCR showed downregulation of COL1A1 and TIMP1, and upregulation of MMP1 and MMP9, indicating a matrix-degradative gene profile. Masson's Trichrome staining revealed reduced collagen deposition and fibrotic band-like structures. Microscopy demonstrated morphological alterations, including cell shrinkage and vacuolation. Docking analysis indicated nicotine binding affinity to COL1A1 with −4.45 kcal/mol and TIMP1 with −5.08 kcal/mol, with stronger affinities for MMP1 with −5.42 kcal/mol and MMP9 (−6.55 kcal/mol), suggesting potential functional interference.</div></div><div><h3>Conclusion</h3><div>ECAE exposure disrupts gingival fibroblast viability and ECM homeostasis through altered gene expression and potential nicotine–protein interactions. These findings suggest potential molecular mechanisms by which e-cigarette aerosols may influence periodontal connective tissue integrity and warrant further investigation using <em>in vivo</em> and clinical models.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 2","pages":"Article 101428"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative research in oral health in India: A bibliometric analysis","authors":"Abhishek Mehta ,&nbsp;Barsha Priya Deka ,&nbsp;Manu Raj Mathur","doi":"10.1016/j.jobcr.2025.11.001","DOIUrl":"10.1016/j.jobcr.2025.11.001","url":null,"abstract":"<div><h3>Background</h3><div>A qualitative research approach is necessary to understand the complexities of social, behavioral, and systemic factors influencing oral health. Despite having a large dental education infrastructure and workforce, a limited number of studies have been published by Indian dental researchers utilizing a qualitative methodology.</div></div><div><h3>Objective</h3><div>Map the existing literature to understand the current landscape of qualitative research in oral health in India.</div></div><div><h3>Method</h3><div>A comprehensive search of prominent databases, along with handsearching, was conducted to shortlist studies based on a predefined criterion. Eligible studies underwent thematic categorization and bibliometric assessment. Keyword co-occurrence and network analysis were performed using VOSviewer software to identify conceptual linkages and emerging research themes.</div></div><div><h3>Results</h3><div>Sixty-four studies met the inclusion criteria. Of these, 56 % were pure qualitative and 43 % were mixed-methods studies, with most published in the last five years. Key focus areas include tobacco cessation, pediatric oral health, and barriers to accessing dental services. Methodologically, the studies relied heavily on interviews and focus group discussions, with limited theoretical integration. Thematic clusters showed dominance of behavior-focused research and regional disparities in study distribution.</div></div><div><h3>Conclusion</h3><div>This is the first review to comprehensively chart the evolution of qualitative research in oral health in India. While momentum is growing, significant gaps remain in methodological depth and thematic diversity. Strengthening training, institutional support, and theoretical engagement is essential for advancing qualitative dental research in India.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 1","pages":"Pages 23-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgical management of gingival recession using pouch and tunnel technique with or without 20 % propolis irrigation: A randomized controlled trial","authors":"Akash Alok Bora,&nbsp;Sumit Malhotra,&nbsp;Joohi Chandra","doi":"10.1016/j.jobcr.2025.12.003","DOIUrl":"10.1016/j.jobcr.2025.12.003","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the adjunctive effect of 20 % propolis irrigation with platelet-rich fibrin (PRF) in the microsurgical Pouch and Tunnel technique for Miller's Class I and II gingival recession defects.</div></div><div><h3>Materials and methods</h3><div>Eighteen patients with Miller's Class I and II recession defects were randomly assigned to two groups: Group A (test, n = 16 sites) received 20 % propolis irrigation followed by the Pouch and Tunnel technique with PRF under a surgical microscope, while Group B (control, n = 13 sites) received the same procedure without propolis. Clinical parameters included Plaque Index (PI), Gingival Index (GI), Probing Depth (PD), Relative Clinical Attachment Level (RCAL), Recession Depth (RD), and Width of Keratinized Tissue (WKT) which were recorded at baseline and 3 months.</div></div><div><h3>Results</h3><div>Both groups showed significant intragroup improvement in GI, PI, RCAL, RD and WKT from baseline to 3 months. Intergroup comparison revealed significantly greater reduction in RD and gain in WKT in the propolis group (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Within the study's limitations, adjunctive use of 20 % propolis irrigation with PRF enhanced root coverage outcomes and increased keratinized tissue width compared to PRF alone. These preliminary findings suggest that propolis may serve as a beneficial adjunct in minimally invasive periodontal plastic surgery.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 1","pages":"Pages 174-179"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}