Journal of oral biology and craniofacial research最新文献

{"title":"Dental pulp stem cells as a novel antifibrotic therapy for oral submucous fibrosis: An in vitro study","authors":"Snehalata Narvekar ,&nbsp;Shridhar D. Baliga ,&nbsp;Punnya V Angadi","doi":"10.1016/j.jobcr.2025.02.002","DOIUrl":"10.1016/j.jobcr.2025.02.002","url":null,"abstract":"<div><h3>Background</h3><div>Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder associated with areca nut consumption. It is characterized by progressive fibrosis, trismus, and a significant risk of malignancy, with limited treatment options primarily offering symptomatic relief. Dental pulp stem cells (DPSCs), a type of mesenchymal stem cells (MSCs), have shown potential for modulating fibrotic conditions through their immunomodulatory and regenerative properties. This study evaluates the antifibrotic potential of DPSCs on OSMF fibroblasts in an in vitro model.</div></div><div><h3>Methods</h3><div>DPSCs were isolated from healthy permanent teeth and characterized using flow cytometry for MSC markers (CD73, CD90, CD44, CD105). Fibroblasts were cultured from OSMF biopsy samples and validated through magnetic sorting and morphological analysis. The antifibrotic effects of DPSCs on fibroblasts were evaluated using assays for collagen gel contraction, proliferation, TGF-β1 secretion, and morphological changes. Data were analyzed for statistical significance using appropriate tests.</div></div><div><h3>Results</h3><div>The mean collagen gel size decreased from 3.235 mm (95 % CI: 1.65–4.82 mm) in the control group to 1.00 mm (95 % CI: −0.27 – 2.27 mm) in the DPSC-treated group. Fibroblast viability declined significantly over 72 h (p &lt; 0.05). TGF-β1 secretion was markedly lower in DPSC-treated fibroblasts (339.38 pg/mL vs 637.61 pg/mL, p = 0.000393, Cohen's d = 19.15).</div></div><div><h3>Conclusion</h3><div>DPSCs exhibit strong antifibrotic properties by inhibiting collagen contraction, suppressing fibroblast proliferation, and reducing TGF-β1 secretion. These findings suggest DPSCs as a promising cell-based therapy for OSMF. Further in vivo studies are warranted for clinical translation.</div></div><div><h3>Trial registration number</h3><div>Not applicable.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 383-389"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in orofacial pain conditions: A narrative review","authors":"Mervin Harris ,&nbsp;Saranya Sreekumar ,&nbsp;Bindhu Paul ,&nbsp;Venkitachalam Ramanarayanan ,&nbsp;Suresh Nayar ,&nbsp;Pramod Subash ,&nbsp;Anil Mathew","doi":"10.1016/j.jobcr.2025.01.029","DOIUrl":"10.1016/j.jobcr.2025.01.029","url":null,"abstract":"<div><div>Orofacial pain conditions, including temporomandibular disorder, migraine, dental pain, and trigeminal neuralgia, are complex, multifactorial disorders with significant impacts on patients' quality of life. As understanding of the pathophysiology of these conditions has deepened, the role of molecular and genetic biomarkers in diagnosing, monitoring, and potentially treating orofacial pain has garnered increasing interest. This scoping review provides a comprehensive overview of the current state of research on biomarkers associated with orofacial pain conditions. By analyzing existing literature, we identify key biomarkers linked to inflammation, neural activity, and tissue degradation that are common across multiple conditions, as well as those specific to particular disorders. Our findings underscore the potential of these biomarkers to guide the development of personalized therapeutic strategies. However, the review also highlights the challenges faced by current biomarker research, including heterogeneity in study designs, small sample sizes, and a lack of longitudinal data. Addressing these challenges is critical for translating biomarker research into clinical practice and improving outcomes for patients with orofacial pain.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 365-382"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of rhBMP-2 in mandibular bone regeneration following tooth extraction through HIF-1α and VEGF-A expression: An Immunohistochemical study","authors":"Christian Khoswanto ,&nbsp;Ira Kusuma Dewi","doi":"10.1016/j.jobcr.2025.02.001","DOIUrl":"10.1016/j.jobcr.2025.02.001","url":null,"abstract":"<div><h3>Background</h3><div>Dentists frequently conduct tooth extractions when there is damage to the tooth or the tissue that supports it. When a tooth is extracted, the alveolar bone will sustain injury. Most of the initial bone volume is lost following the healing phase after extraction. Rehabilitation must start as soon as a tooth is missing, mainly because the alveolar bone is severely damaged during the tooth extraction, particularly in the buccal region where the tooth is removed. Dental implant is one method of replacing lost teeth. One of the most important elements influencing the clinical result of dental implants is a change in the dimension of the alveolar bone. Several bone-grafting techniques, such as socket preservation techniques, have been developed to increase the volume of bone throughout the healing phase after tooth extraction. This study aims to assess the impact rhBMP-2 on creating bone regeneration through VEGF and HIF-1α in the mandibular socket post-extraction in Wistar rats.</div></div><div><h3>Method</h3><div>On the anterior side of the mandible, in the socket area where the tooth was extracted, rhBMP-2 was injected into the socket, and the xenograft material was applied with a syringe. Male, 9-week-old Wistar rats were chosen (n = 30).</div></div><div><h3>Result</h3><div>Our statistical evaluations have revealed a significantly higher VEGF-A and HIF-1α expression post-extraction of the rhBMP-2 and xenograft group compared to other group treatments. These findings are significant as they provide a deeper understanding of the mechanisms involved in bone regeneration post-extraction.</div></div><div><h3>Conclusion</h3><div>Our study suggests that injecting rhBMP-2 into the grafted material and socket extraction during GBR dramatically increases the expression of VEGF-A and HIF-1α. These findings have the potential to significantly impact oral surgery and regenerative dentistry, opening up new possibilities for enhancing bone regeneration techniques.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 359-364"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of pulpal response at varying remaining dentin thickness in teeth restored with resin bulk fill composite, conventional glass ionomer cement and silver amalgam: Histomorphometric analysis","authors":"Ankita Agarwal ,&nbsp;Promila Verma ,&nbsp;Rakesh Yadav ,&nbsp;Ramesh Bharti ,&nbsp;Rhythm Bains ,&nbsp;Madhu Kumar ,&nbsp;Dipti Shastri","doi":"10.1016/j.jobcr.2024.12.020","DOIUrl":"10.1016/j.jobcr.2024.12.020","url":null,"abstract":"<div><h3>Objective</h3><div>To compare and evaluate the pulp response to GC glass ionomer cement, SDR plus bulk fill composite and amalgam against gold standard calcium hydroxide cement at varying remaining dentin thickness, in teeth planned for orthodontic extraction.</div></div><div><h3>Method</h3><div>Thirty-eight human premolars were prepared with 2 mm or 2.5 mm depth cavities. They were restored with GC conventional glass ionomer cement, SDR plus bulk fill composite, amalgam, or lined with Dycal and restored with GIC. Two teeth were used as intact controls. After a 7-day interval, the teeth were extracted and processed for histological examination of the pulp and the thickness of the remaining dentin between the cavity floor and pulp tissue.</div></div><div><h3>Results</h3><div>All experimental groups showed some degree of inflammatory response. A significantly higher inflammatory response and more tissue disorganization were observed with SDR bulk fill composite (p &lt; 0.05) compared to Glass ionomer cement, amalgam and Dycal at both cavity depths of 2 mm or 2.5 mm. The mean RDTs ranged from 346 μm to 1025 μm.</div></div><div><h3>Conclusions</h3><div>The study concluded that critical RDT varies for different restorative materials. It was observed that both glass ionomer cement and amalgam demonstrated acceptable biocompatibility when used in deep cavities. At the same time, SDR plus bulk fill composite proved to be the least biocompatible.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 347-354"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tip up - Simplified technique for non-surgical rhinoplasty: A case series","authors":"Cláudia Almeida ,&nbsp;Victor Rogerio ,&nbsp;Gabriela Giro ,&nbsp;Victor Munoz-Lora ,&nbsp;Marcelo Germani","doi":"10.1016/j.jobcr.2025.01.013","DOIUrl":"10.1016/j.jobcr.2025.01.013","url":null,"abstract":"<div><div>Non-surgical nasal rhinoplasty using hyaluronic acid (HA) is a technique that has been widely adopted due to its minimally invasive and reversible nature. Reshaping the nose with HA is becoming increasingly popular for its quick and safe outcomes, serving as an effective alternative for correcting minor nasal deformities. The proposed approach, named the Tip Up (TU) technique, focuses on strategic injection sites, specifically in the Nasal Tip region, Nasal Spine, and Columella, utilizing minimal amounts of the product to minimize risks and enhance the predictability of the results. Procedures are performed under anesthesia without vasoconstrictors to prevent ischemia, and careful selection of the product ensures subtle and precise corrections. This case series details all aspects of the TU technique, highlighting the satisfactory and predictable aesthetic results achieved through a safe and reliable procedure.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 355-358"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioprinting techniques for regeneration of oral and craniofacial tissues: Current advances and future prospects","authors":"Shailesh Varshney ,&nbsp;Anshuman Dwivedi ,&nbsp;Vibha Pandey","doi":"10.1016/j.jobcr.2025.01.019","DOIUrl":"10.1016/j.jobcr.2025.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Regenerative dentistry aims to reinstate, fix, renew, and regrow tissues within the oral and craniofacial domain. Existing regenerative methods are based on insights into tissue biology or disease processes that lead to tissue degradation. However, achieving complete and functional Tissue regeneration remains a primary challenge in real-world medical scenarios.</div></div><div><h3>Aim</h3><div>The review focuses on the application of bioprinting techniques for rejuvenating intricate Oral and craniofacial tissues, such as craniofacial bone, periodontal ligament, cementum, dental pulp, temporomandibular joint cartilage, and whole teeth.</div></div><div><h3>Methods</h3><div>Bioprinting, a cutting-edge technology in regenerative dentistry, strives to create entirely new Functional tissues and organs. This approach merges principles from engineering and biology to produce three-dimensional biologically operational constructs containing bioactive substances, Living cells and cell clusters using automated bioprinters. The review summarizes the outcomes achieved through bioprinting techniques in both in vitro (laboratory experiments) and in vivo (Studies on living organisms) experiments.</div></div><div><h3>Result</h3><div>The emergence of this innovative tissue engineering technology has yielded highly promising outcomes during the experimental stages.</div></div><div><h3>Conclusion</h3><div>These promising experimental results necessitate replication through human clinical trials to ascertain the viability of bioprinting techniques for mainstream clinical implementation in regenerative dentistry.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 331-346"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Effect of oral systemic administration of vitamin D on the rate of maxillary canine retraction: A randomized controlled trial”","authors":"Davender Kumar ,&nbsp;Revathi Mn ,&nbsp;Rekha Sharma ,&nbsp;Ashuma Sachdeva ,&nbsp;Nameksh Raj Bhupali ,&nbsp;Ravinder Solanki","doi":"10.1016/j.jobcr.2025.01.017","DOIUrl":"10.1016/j.jobcr.2025.01.017","url":null,"abstract":"<div><h3>Objective</h3><div>The trial was conducted to determine the effects of systemically delivered Vitamin D (1,25 dihydroxycholecalciferol) on the rate of maxillary canine retraction till the space closure and on the root resorption.</div></div><div><h3>Materials and methods</h3><div>A two-arm parallel randomized controlled trial was conducted in patients with Angle's Class I bimaxillary protrusion requiring at least upper first premolars extraction and distal movement of canine for malocclusion correction. The enrolled patients were randomized and allocated to the experimental group (Oral Vitamin D = 0.25 μg given) and control group (Placebo given). The canine retraction was initiated using nickel-titanium (NiTi) closed coil springs delivering a force of 100 gm per side and Vitamin D levels were monitored at monthly intervals. The patients' casts were digitally scanned and examined for differences in the rate of canine retraction at initial (T0), 4 weeks (T1), 8 weeks (T2), 12 weeks (T3), 16 weeks (T4) and 20 weeks (T5) intervals were calculated. The volumetric root resorption was done on CBCT of the area of interest at T0 and after completion of retraction. Descriptive statistics and paired <em>t</em>-test were used to determine any differences.</div></div><div><h3>Results</h3><div>32 patients (18–24 years) were randomized in the experimental group (n = 16) and control group (n = 16) and no dropout was noted till the end of the study. The results showed a statistically significant increase in the rate of canine retraction in the experimental group as compared to the control group at different time intervals. The differences in the mean canine retraction between group 1 and group 2 at T1-T0, T2-T1, T3-T2, T4-T3, and T4-T0 were 0.28 ± 0.12, 0.29 ± 0.10, 0.31 ± 0.08, 0.37 ± 0.06 and 1.18 ± 0.10 mm respectively. The total mean canine retraction for group 1 was achieved at T4 time interval while it was achieved at T5 interval for group 2. The intergroup comparison of maxillary canine roots showed no statistically significant difference in volumetric root resorption.</div></div><div><h3>Conclusion</h3><div>The active form of vitamin D can be an effective agent to accelerate orthodontic tooth movement (OTM).</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 281-287"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner","authors":"Mohika Damle,&nbsp;Ponsekar Abraham Anandapandian,&nbsp;B. Eswaran,&nbsp;Swapnaneel Pradhan,&nbsp;Silvin Joe C J,&nbsp;Shreyas Dhumke","doi":"10.1016/j.jobcr.2025.01.007","DOIUrl":"10.1016/j.jobcr.2025.01.007","url":null,"abstract":"<div><h3>Introduction</h3><div>The rough surface of dentures, coupled with xerostomia and immunosuppression, fosters microbial growth and colonization, with <em>Candida albicans</em> being a primary culprit. Tissue conditioners, used to reline ill-fitting dentures, can temporarily alleviate discomfort but are prone to microbial colonization. To address this, researchers have explored incorporating antifungal agents directly into tissue conditioners. Nanoparticles, particularly green-synthesized ones derived from fenugreek, have shown significant antifungal efficacy. Combining fenugreek extract with chitosan, can further improve antifungal outcomes due to its excellent drug delivery, mucoadhesive properties, and bioavailability<strong>.</strong></div></div><div><h3>Aim</h3><div>To synthesize Chitosan mediated Fenugreek nanocomposite (1.5 %,2 %,2.5 % by weight concentrations) and evaluate its antifungal efficacy on heat cure denture base relined with tissue conditioner mixed with nanocomposite by assessing fungal colony formation after 1st day, 1st week and 2nd week.</div></div><div><h3>Methodology</h3><div>After synthesizing chitosan mediated fenugreek Nanocomposite, its characterization was performed using SEM, FTIR analysis and UV–Vis spectroscopy. Heat cure denture base discs coated with tissue conditioner-nanocomposite mixture were used to transfer fungal cultures onto Rose Bengal agar to assess colony formation.</div></div><div><h3>Results and discussion</h3><div>Chitosan-fenugreek nanoparticles were synthesized using the ionic gelation method, with fenugreek extract used for green synthesis. Kruskal-Wallis test showed significant effects over time, with 2.5 % group showing lowest fungal growth at 521 CFU/mL, followed by 2 % group at 587 CFU/mL, while the 1.5 % nanocomposite group still displayed considerable fungal growth.</div></div><div><h3>Conclusion</h3><div>Incorporating chitosan-mediated fenugreek nanocomposite into denture tissue conditioners offers a promising approach to reducing Candidal growth, potentially improving oral health outcomes for denture wearers.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 271-276"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiofilm efficiency of silver and copper nanoparticle incorporated calcium hydroxide as an intracanal medicament: An in vitro study","authors":"Murali H. Rao ,&nbsp;Krishnan Rajkumar ,&nbsp;Gopal Pavithra ,&nbsp;Ramya Ramadoss ,&nbsp;Suryanarayanan Shankar ,&nbsp;Krishnamachari Janani ,&nbsp;Kumar Chandan Srivastava ,&nbsp;Deepti Shrivastava ,&nbsp;Dinesh Rokaya","doi":"10.1016/j.jobcr.2025.01.020","DOIUrl":"10.1016/j.jobcr.2025.01.020","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Silver (Ag) and Copper (Cu) Nanoparticles (NP) are a potential substitute for disinfection during endodontic therapy because of their antibacterial action against an array of pathogens, including resistant strains. This study aimed to assess the antibiofilm efficiency of calcium hydroxide modified with Ag and Cu NP suspension against <em>E. faecalis</em>, using confocal laser scanning microscopy (CLSM) and colony forming units (CFU) analysis.</div></div><div><h3>Methods</h3><div>Dentine blocks were inoculated with Enterococcus faecalis for one week and 1 week-old biofilm of <em>E. feacalis</em> were randomly divided into 4 groups, control, calcium hydroxide, calcium hydroxide +2 % Cu NP and calcium hydroxide +2 % Ag NP. Following the incubation of the specimens with the medicament for 24 h at 37C, CLSM was used to evaluate the reduction in biovolume of the biofilm and the CFU was determined to assess the antimicrobial action of the NP-modified calcium hydroxide.</div></div><div><h3>Results</h3><div>CLSM images revealed a significant reduction in the thickness of biofilm in both Ag and Cu groups compared to calcium hydroxide alone. The CFU results showed that group 4 and group 3 showed significantly less CFU followed by group 2 and group 1 (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Adding Cu and Ag NP to calcium hydroxide intracanal medication significantly increases its antibacterial activity against <em>E. faecalis</em>.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 319-324"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined tracheostomy and maxillomandibular advancement for extremely severe obstructive sleep apnea: A case report","authors":"Ning Zhou ,&nbsp;Jean-Pierre T.F. Ho ,&nbsp;Jan de Lange","doi":"10.1016/j.jobcr.2025.01.028","DOIUrl":"10.1016/j.jobcr.2025.01.028","url":null,"abstract":"<div><div>Tracheostomy and maxillomandibular advancement (MMA) are both highly effective surgical treatments for adult obstructive sleep apnea (OSA). The present case study described the successful application of combined tracheostomy and MMA for the treatment of extremely severe OSA.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 277-280"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}