Journal of oral biology and craniofacial research最新文献

{"title":"Bioprinting techniques for regeneration of oral and craniofacial tissues: Current advances and future prospects","authors":"Shailesh Varshney ,&nbsp;Anshuman Dwivedi ,&nbsp;Vibha Pandey","doi":"10.1016/j.jobcr.2025.01.019","DOIUrl":"10.1016/j.jobcr.2025.01.019","url":null,"abstract":"<div><h3>Background</h3><div>Regenerative dentistry aims to reinstate, fix, renew, and regrow tissues within the oral and craniofacial domain. Existing regenerative methods are based on insights into tissue biology or disease processes that lead to tissue degradation. However, achieving complete and functional Tissue regeneration remains a primary challenge in real-world medical scenarios.</div></div><div><h3>Aim</h3><div>The review focuses on the application of bioprinting techniques for rejuvenating intricate Oral and craniofacial tissues, such as craniofacial bone, periodontal ligament, cementum, dental pulp, temporomandibular joint cartilage, and whole teeth.</div></div><div><h3>Methods</h3><div>Bioprinting, a cutting-edge technology in regenerative dentistry, strives to create entirely new Functional tissues and organs. This approach merges principles from engineering and biology to produce three-dimensional biologically operational constructs containing bioactive substances, Living cells and cell clusters using automated bioprinters. The review summarizes the outcomes achieved through bioprinting techniques in both in vitro (laboratory experiments) and in vivo (Studies on living organisms) experiments.</div></div><div><h3>Result</h3><div>The emergence of this innovative tissue engineering technology has yielded highly promising outcomes during the experimental stages.</div></div><div><h3>Conclusion</h3><div>These promising experimental results necessitate replication through human clinical trials to ascertain the viability of bioprinting techniques for mainstream clinical implementation in regenerative dentistry.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 331-346"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Effect of oral systemic administration of vitamin D on the rate of maxillary canine retraction: A randomized controlled trial”","authors":"Davender Kumar ,&nbsp;Revathi Mn ,&nbsp;Rekha Sharma ,&nbsp;Ashuma Sachdeva ,&nbsp;Nameksh Raj Bhupali ,&nbsp;Ravinder Solanki","doi":"10.1016/j.jobcr.2025.01.017","DOIUrl":"10.1016/j.jobcr.2025.01.017","url":null,"abstract":"<div><h3>Objective</h3><div>The trial was conducted to determine the effects of systemically delivered Vitamin D (1,25 dihydroxycholecalciferol) on the rate of maxillary canine retraction till the space closure and on the root resorption.</div></div><div><h3>Materials and methods</h3><div>A two-arm parallel randomized controlled trial was conducted in patients with Angle's Class I bimaxillary protrusion requiring at least upper first premolars extraction and distal movement of canine for malocclusion correction. The enrolled patients were randomized and allocated to the experimental group (Oral Vitamin D = 0.25 μg given) and control group (Placebo given). The canine retraction was initiated using nickel-titanium (NiTi) closed coil springs delivering a force of 100 gm per side and Vitamin D levels were monitored at monthly intervals. The patients' casts were digitally scanned and examined for differences in the rate of canine retraction at initial (T0), 4 weeks (T1), 8 weeks (T2), 12 weeks (T3), 16 weeks (T4) and 20 weeks (T5) intervals were calculated. The volumetric root resorption was done on CBCT of the area of interest at T0 and after completion of retraction. Descriptive statistics and paired <em>t</em>-test were used to determine any differences.</div></div><div><h3>Results</h3><div>32 patients (18–24 years) were randomized in the experimental group (n = 16) and control group (n = 16) and no dropout was noted till the end of the study. The results showed a statistically significant increase in the rate of canine retraction in the experimental group as compared to the control group at different time intervals. The differences in the mean canine retraction between group 1 and group 2 at T1-T0, T2-T1, T3-T2, T4-T3, and T4-T0 were 0.28 ± 0.12, 0.29 ± 0.10, 0.31 ± 0.08, 0.37 ± 0.06 and 1.18 ± 0.10 mm respectively. The total mean canine retraction for group 1 was achieved at T4 time interval while it was achieved at T5 interval for group 2. The intergroup comparison of maxillary canine roots showed no statistically significant difference in volumetric root resorption.</div></div><div><h3>Conclusion</h3><div>The active form of vitamin D can be an effective agent to accelerate orthodontic tooth movement (OTM).</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 281-287"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner","authors":"Mohika Damle,&nbsp;Ponsekar Abraham Anandapandian,&nbsp;B. Eswaran,&nbsp;Swapnaneel Pradhan,&nbsp;Silvin Joe C J,&nbsp;Shreyas Dhumke","doi":"10.1016/j.jobcr.2025.01.007","DOIUrl":"10.1016/j.jobcr.2025.01.007","url":null,"abstract":"<div><h3>Introduction</h3><div>The rough surface of dentures, coupled with xerostomia and immunosuppression, fosters microbial growth and colonization, with <em>Candida albicans</em> being a primary culprit. Tissue conditioners, used to reline ill-fitting dentures, can temporarily alleviate discomfort but are prone to microbial colonization. To address this, researchers have explored incorporating antifungal agents directly into tissue conditioners. Nanoparticles, particularly green-synthesized ones derived from fenugreek, have shown significant antifungal efficacy. Combining fenugreek extract with chitosan, can further improve antifungal outcomes due to its excellent drug delivery, mucoadhesive properties, and bioavailability<strong>.</strong></div></div><div><h3>Aim</h3><div>To synthesize Chitosan mediated Fenugreek nanocomposite (1.5 %,2 %,2.5 % by weight concentrations) and evaluate its antifungal efficacy on heat cure denture base relined with tissue conditioner mixed with nanocomposite by assessing fungal colony formation after 1st day, 1st week and 2nd week.</div></div><div><h3>Methodology</h3><div>After synthesizing chitosan mediated fenugreek Nanocomposite, its characterization was performed using SEM, FTIR analysis and UV–Vis spectroscopy. Heat cure denture base discs coated with tissue conditioner-nanocomposite mixture were used to transfer fungal cultures onto Rose Bengal agar to assess colony formation.</div></div><div><h3>Results and discussion</h3><div>Chitosan-fenugreek nanoparticles were synthesized using the ionic gelation method, with fenugreek extract used for green synthesis. Kruskal-Wallis test showed significant effects over time, with 2.5 % group showing lowest fungal growth at 521 CFU/mL, followed by 2 % group at 587 CFU/mL, while the 1.5 % nanocomposite group still displayed considerable fungal growth.</div></div><div><h3>Conclusion</h3><div>Incorporating chitosan-mediated fenugreek nanocomposite into denture tissue conditioners offers a promising approach to reducing Candidal growth, potentially improving oral health outcomes for denture wearers.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 271-276"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiofilm efficiency of silver and copper nanoparticle incorporated calcium hydroxide as an intracanal medicament: An in vitro study","authors":"Murali H. Rao ,&nbsp;Krishnan Rajkumar ,&nbsp;Gopal Pavithra ,&nbsp;Ramya Ramadoss ,&nbsp;Suryanarayanan Shankar ,&nbsp;Krishnamachari Janani ,&nbsp;Kumar Chandan Srivastava ,&nbsp;Deepti Shrivastava ,&nbsp;Dinesh Rokaya","doi":"10.1016/j.jobcr.2025.01.020","DOIUrl":"10.1016/j.jobcr.2025.01.020","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Silver (Ag) and Copper (Cu) Nanoparticles (NP) are a potential substitute for disinfection during endodontic therapy because of their antibacterial action against an array of pathogens, including resistant strains. This study aimed to assess the antibiofilm efficiency of calcium hydroxide modified with Ag and Cu NP suspension against <em>E. faecalis</em>, using confocal laser scanning microscopy (CLSM) and colony forming units (CFU) analysis.</div></div><div><h3>Methods</h3><div>Dentine blocks were inoculated with Enterococcus faecalis for one week and 1 week-old biofilm of <em>E. feacalis</em> were randomly divided into 4 groups, control, calcium hydroxide, calcium hydroxide +2 % Cu NP and calcium hydroxide +2 % Ag NP. Following the incubation of the specimens with the medicament for 24 h at 37C, CLSM was used to evaluate the reduction in biovolume of the biofilm and the CFU was determined to assess the antimicrobial action of the NP-modified calcium hydroxide.</div></div><div><h3>Results</h3><div>CLSM images revealed a significant reduction in the thickness of biofilm in both Ag and Cu groups compared to calcium hydroxide alone. The CFU results showed that group 4 and group 3 showed significantly less CFU followed by group 2 and group 1 (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Adding Cu and Ag NP to calcium hydroxide intracanal medication significantly increases its antibacterial activity against <em>E. faecalis</em>.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 319-324"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined tracheostomy and maxillomandibular advancement for extremely severe obstructive sleep apnea: A case report","authors":"Ning Zhou ,&nbsp;Jean-Pierre T.F. Ho ,&nbsp;Jan de Lange","doi":"10.1016/j.jobcr.2025.01.028","DOIUrl":"10.1016/j.jobcr.2025.01.028","url":null,"abstract":"<div><div>Tracheostomy and maxillomandibular advancement (MMA) are both highly effective surgical treatments for adult obstructive sleep apnea (OSA). The present case study described the successful application of combined tracheostomy and MMA for the treatment of extremely severe OSA.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 277-280"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the predictive power of antinuclear antibodies and Rheumatoid factor correlations in anticipating therapeutic outcomes for female patients with coexisting Sjögren's syndrome and Rheumatoid arthritis","authors":"Anitha Krishnan Pandarathodiyil ,&nbsp;Hema Shree K ,&nbsp;Pratibha Ramani ,&nbsp;Sivapathasundharam B. ,&nbsp;Ramya Ramadoss","doi":"10.1016/j.jobcr.2025.01.012","DOIUrl":"10.1016/j.jobcr.2025.01.012","url":null,"abstract":"<div><h3>Background</h3><div>Sjögren's Syndrome (SS) and Rheumatoid Arthritis (RA) are autoimmune conditions that often coexist in female patients. Biomarkers such as antinuclear antibodies (ANA) and rheumatoid factor (RF) are used for diagnosis, but their predictive power for treatment outcomes remains unclear. This study aims to investigate the correlation between age, ANA, RF, and treatment response in female patients with both SS and RA.</div></div><div><h3>Objective</h3><div>To evaluate the relationships between age, ANA, RF levels, RA (disease present), and treatment response using Pearson correlation analysis and a neural network model, to predict treatment outcomes in patients with coexisting SS and RA.</div></div><div><h3>Methods</h3><div>A cohort of 56 female patients aged 30–73 was analyzed. Descriptive statistics provided an overview of key variables, followed by Pearson correlation analysis to assess relationships between age, ANA, RF, RA, and treatment response. A neural network model was developed to predict treatment response based on age, ANA, and RF levels, using a training-to-testing split of 81.3 % and 18.8 %, respectively.</div></div><div><h3>Results</h3><div>The Pearson correlation analysis revealed a significant positive correlation between age and ANA levels (r = .541, p = 0.031), though no significant correlations were found between age, RF, RA, and treatment response. The neural network model achieved an accuracy of 92.3 % during training and 100 % accuracy during testing for most treatment categories. However, the model struggled to accurately distinguish between certain classes, particularly treatment categories 1 and 3.</div></div><div><h3>Conclusion</h3><div>Age showed a significant correlation with ANA levels, indicating that older patients may have elevated ANA. The neural network model demonstrated strong predictive power for treatment response, although further refinement is needed to improve its ability to distinguish between all response categories. These findings suggest that machine learning models could enhance personalized treatment strategies for patients with SS and RA, but additional validation with larger datasets is required.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 288-296"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of cytotoxicity of clear aligners coated with zinc oxide nanoparticles","authors":"Indu Ravi,&nbsp;Vignesh Kailasam","doi":"10.1016/j.jobcr.2025.01.010","DOIUrl":"10.1016/j.jobcr.2025.01.010","url":null,"abstract":"<div><h3>Background</h3><div>Coating with nanoparticles can have clinical benefits like anti-bacterial activity and therefore an improvement in oral hygiene. However, the toxicity of these coatings is not known. The aim was to assess and compare the viability of human gingival fibroblasts (HGFs) of clear aligners coated with zinc oxide nanoparticles of different sizes.</div></div><div><h3>Methods</h3><div>Zinc oxide nanoparticles of 30 nm, 60 nm &amp; 90 nm were sputter coated on five aligner samples and were compared with 5 uncoated samples. The thickness of the coating was standardized at 100 nm. The cytotoxicity on HGFs was assessed at day 0, 7 and 14 using assay ([3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]).</div></div><div><h3>Results</h3><div>The coated aligners exhibited “slight-cytotoxicity” on day 7 and day 14 compared to the uncoated aligners which were categorized as “no cytotoxicity”. Though the cell viability decreased in both the coated and uncoated aligners from day 0 to day 7 to day 14, this decrease was statistically significant for the coated aligners only. (p &lt; 0.05) The greater cytotoxicity observed for the coated aligners was statistically significant only on day 14 (p &lt; 0.001). Within the coated aligners, the 90 nm coating showed the least cytotoxicity, when compared with 60 nm and 30 nm at the time points measured, but this difference was significant only between the 90 nm and 60 nm group on day 14.</div></div><div><h3>Conclusion</h3><div>The mean decrease in cell viability for the uncoated aligner within the “no cytotoxicity range” while it was within the “slight cytotoxicity range” for the coated aligner. An increase in particle size demonstrated lesser cytotoxicity. ,.Zinc oxide coated aligners should be used with caution after day 7 even though there is only slight toxicity.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 262-265"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of cyclic fatigue in three pediatric endodontic rotary file systems in root canals of primary molars: A finite element analysis (FEA)","authors":"S.S. Monika sri,&nbsp;K.C. Vignesh,&nbsp;K. Vivek,&nbsp;Kavitha Swaminathan,&nbsp;Selvakumar Haridoss","doi":"10.1016/j.jobcr.2025.01.023","DOIUrl":"10.1016/j.jobcr.2025.01.023","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to evaluate the cyclic fatigue resistance of three different pediatric endodontic rotary files in the root canals of primary molars using finite element analysis (FEA). The research focuses on understanding the mechanical behavior of the files under varying canal curvatures to determine their suitability for pediatric endodontics.</div></div><div><h3>Methods</h3><div>Finite Element Analysis (FEA) was utilized to simulate cyclic fatigue performance in primary molar canals with curvatures of 30°, 60°, and 90°. The rotary files made up of nickel-titanium (NiTi) alloys included in this study were Kedo SG, Neoendo Pedo Flex, and Pro AF Baby. Stress distribution, maximum stress values, and cyclic fatigue resistance were evaluated to identify differences in performance. Simulations were conducted under controlled conditions to model real-world clinical scenarios. Stress distribution and the number of cycles until failure were analyzed using Goodman's fatigue model and the S-N curve.</div></div><div><h3>Results</h3><div>The Pro AF Baby files exhibited the highest cyclic fatigue resistance and the more favourable stress distribution across all canal profiles, due to its triangular cross-sectional geometry. Whereas, Kedo SG and Neoendo Pedo Flex demonstrated higher stress levels and lower fatigue life, particularly in severe curvatures (90°), indicating increased susceptibility to failure. Elevated stress concentrations were observed near the apical tip, correlating with reduced fatigue life as canal curvature increased.</div></div><div><h3>Conclusion</h3><div>Pro AF Baby B2 demonstrated better fatigue resistance and safety for endodontic procedures in primary molars with complex root canal curvatures. These findings emphasize the importance of material properties and file design in improving clinical outcomes. Future research should focus on long-term clinical validation and further optimization of rotary file systems for pediatric dentistry.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 310-318"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of age on the treatment duration and proposed “impacted incisor severity score” of impacted maxillary incisor: A retrospective study","authors":"Umer Mukhtar,&nbsp;Manoj kumar Jaiswal,&nbsp;Rigzen Tamchos,&nbsp;Ashima Goyal,&nbsp;Satinder Pal Singh,&nbsp;Aditi Kapur","doi":"10.1016/j.jobcr.2025.01.024","DOIUrl":"10.1016/j.jobcr.2025.01.024","url":null,"abstract":"<div><h3>Background</h3><div>Absence of anterior maxillary teeth has a significantly impact on esthetics, speech, mastication, and psychosocial well-being in young patients.</div></div><div><h3>Materials and methods</h3><div>A retrospective study was conducted from January 2012 to January 2022, the data include children (8–15 years) with maxillary impacted incisors. After initial screening of the digital records, 75 cases with 80 impacted maxillary central incisors were recruited; 9 cases were excluded due to incomplete records.</div></div><div><h3>Results</h3><div>75 patients were found to have impacted incisors with a prevalence of 0.21 %. Patients were then divided into group 1 (&lt;11years) and group 2 (11–15years) with a mean age of 9.51 ± 1.2 and 13.31 ± 1.74, respectively. Patients who reported at 11–15 years of age were significantly more as compared to &lt;11years (p = 0.014). Among the various etiological factors, physical obstruction or inadequate space was found to be most common. Among dilacerated teeth, 75 % had a history of trauma, and only 35 % of normal impacted central incisors had a history of trauma (p = 0.00139). The mean duration of treatment time was found to be 16.77 ± 8.83months and 21.75 ± 6.08months for impacted incisors with normal morphology and with dilaceration, respectively and the difference was statistically significant (p = 0.042).</div></div><div><h3>Conclusions</h3><div>Considering the age of the patient, it does not show significant effect on the duration of treatment, but a change in root morphology like dilaceration, significantly increases the duration of treatment. In addition, the proposed objective scoring system “Impacted incisor severity score” could help the clinicians to assess the difficulty and duration of treatment of impacted incisors.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 297-304"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of Methylene Blue mediated antimicrobial Photodynamic Therapy (PDT) using 680 nm Diode Laser in patients undergoing Open Flap Debridement: An Original Research","authors":"Soundarya Singh,&nbsp;Manisha Rout,&nbsp;Mayur Kaushik,&nbsp;Shilpa Sharma,&nbsp;Aprajita Srivastava","doi":"10.1016/j.jobcr.2025.01.022","DOIUrl":"10.1016/j.jobcr.2025.01.022","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory periodontal disease caused by dental plaque is characterised by the clinical signs of inflammation and loss of periodontal tissue support. The mechanical removal of this biofilm and adjunctive use of antibacterial disinfectants and antibiotics have been the conventional methods of periodontal therapy. The possibility of the development of resistance to antibiotics by the target organism has led to the development of a new antimicrobial concept with fewer complications. Photodynamic therapy (PDT) involves the use of low-power lasers with appropriate wavelengths to kill microorganisms treated with a photosensitiser drug. PDT could be a useful adjunct to mechanical as well as antibiotics in eliminating periodontal-pathogenic bacteria.</div></div><div><h3>Methods</h3><div>The patients selected were randomly divided into two groups. In the test group, Open Flap Debridement (OFD) with Methylene Blue-mediated Antimicrobial Photodynamic Therapy (PDT) using 680 nm Diode Laser application was done, and in the control group, OFD alone.</div></div><div><h3>Results</h3><div>The results of this study showed that diode laser irradiation (680 nm) combined with methylene blue dye reduced pocket probing depth and gingival bleeding by up to 95.85 % in the group treated with PDT with 5 min of irradiation.</div></div><div><h3>Conclusions</h3><div>The adjunctive use of photodynamic therapy with Diode 680 nm Laser and Methylene Blue Photosensitiser can be beneficial in reducing pocket probing depth, plaque index, and gingival bleeding index. Antimicrobial photodynamic therapy may hold promise as a substitute for currently available chemotherapy in the treatment of periodontal and peri-implant disease and in endodontic therapy.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 266-270"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}