Journal of oral biology and craniofacial research最新文献

{"title":"Influence of age, sex, and presence of cleft lip and palate on the quantity and quality of saliva-derived DNA","authors":"Lina M. Escobar ,&nbsp;Zita Bendahan ,&nbsp;Deisy Abril ,&nbsp;David Díaz-Baez ,&nbsp;Adolfo Paternina ,&nbsp;Farith González-Martinez ,&nbsp;Ma Clara González-Carrera","doi":"10.1016/j.jobcr.2025.01.030","DOIUrl":"10.1016/j.jobcr.2025.01.030","url":null,"abstract":"<div><div>The quantity and quality of DNA are crucial factors in determining polymorphisms in samples from individuals with and without pathologies such as cleft lip and palate (CL/P). Saliva is increasingly being evaluated as a collection method. This study aimed to compare saliva DNA concentrations from individuals of different ages with and without CL/P.</div><div>Saliva samples were collected, DNA was extracted and the quantification was performed by spectrophotometry. Kruskal-Wallis test was used to compare frequencies between groups, and Spearman's rho for correlations.</div><div>We obtained saliva DNA from 314 individuals: 107 with CL/P (mean age: 12.7 ± 6.5 years), 103 parents of children with CL/P (mean age: 41.1 ± 9.3 years), 52 individuals without CL/P under 18 years old (controls), and 52 individuals without CL/P over 18 years old (controls). The sample comprised 32.2 % females and 67.8 % males.</div><div>Statistically significant differences in DNA concentrations were found between individuals under and over 18 years old (12.38 and 21.3 ng/μl, respectively, p = 0.0001), but no differences were observed between males and females. Individuals with CL/P had lower DNA concentrations (12.45 ng/μl) compared to their parents and controls (21.95 and 21.15 ng/μl, respectively). Our results showed a direct correlation between age and DNA concentration in individuals with CL/P under 18 years old (R = 0.328).</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 246-249"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative alterations in exfoliated oral mucosa cells of patients with major depressive disorder","authors":"Lukas Mendes de Abreu ,&nbsp;Cintia Rodrigues da Silva ,&nbsp;Ana Laura Ferreira Bortoleto ,&nbsp;Giovana Barros Nunes ,&nbsp;Matheus Martins Gracia ,&nbsp;Rafael Akira Tzanno Murayama ,&nbsp;Daniel Galera Bernabé ,&nbsp;Gisele Zoccal Mingoti","doi":"10.1016/j.jobcr.2025.01.026","DOIUrl":"10.1016/j.jobcr.2025.01.026","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate oxidative stress markers in the oral mucosal cells of individuals diagnosed with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>A case-control design was used, including twenty patients diagnosed with MDD, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, and twenty healthy controls. Oral exfoliated cells were collected from all participants. Intracellular levels of reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), caspase-3 and -7 activity, and reduced glutathione (GSH) were measured in Arbitrary Fluorescence Units (AFU).</div></div><div><h3>Results</h3><div>The MDD group demonstrated significantly elevated intracellular ROS levels (p = 0.0012) and caspase-3 and -7 activity (p = 0.0171) in comparison to the control group. Additionally, a decrease in ΔΨm expression was observed in the oral cells of MDD patients (p = 0.0265), whereas GSH expression levels did not differ significantly between the two groups (p = 0.8908).</div></div><div><h3>Conclusions</h3><div>The findings indicate heightened oxidative stress in the oral exfoliated cells of individuals with MDD. This study supports the potential use of oral cells as a non-invasive biomarker source for assessing oxidative stress in depressive disorders.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 256-261"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the cost-effectiveness of prosthetic rehabilitation for partially edentulous teeth in India: A comparative study of Clasp-Retained RPDs, Thermoplastic Resin RPDs, and Cast Partial Dentures","authors":"Subhash V ,&nbsp;Aswini Kumar K ,&nbsp;Vineetha Karuveettil","doi":"10.1016/j.jobcr.2025.01.014","DOIUrl":"10.1016/j.jobcr.2025.01.014","url":null,"abstract":"<div><h3>Background</h3><div>With rising life expectancy, partial edentulism has increased, particularly in developing nations where economic constraints, limited awareness, and inadequate dental care exacerbate the burden on aging populations. Patients with fewer than 20 teeth often experience a reduction in Oral Health-Related Quality of Life (OHRQoL), emphasizing the need for effective tooth replacement. Removable partial dentures (RPDs) are versatile, cost-effective solutions for partial tooth loss, including metal clasp-retained RPDs (MC-RPDs), thermoplastic resin RPDs (TR-RPDs), and cast partial dentures (CPDs).</div></div><div><h3>Methods</h3><div>This study evaluates the oral health-related quality of life, patient satisfaction, and cost-effectiveness of these three RPD types. A cross-sectional study was conducted with 42 participants, divided into three groups: MC-RPD, TR-RPD, and CPD, each with 14 patients. The Oral Health Impact Profile (OHIP-14) and Satisfaction Questionnaire (SAT) were administered at baseline and three months post-denture delivery. The study adhered to Consolidated Health Economic Evaluation Reporting Standards.</div></div><div><h3>Results</h3><div>Results showed significant differences in OHIP scores between the groups, with CPD offering the highest quality of life, followed by TR-RPD, and MC-RPD. Post-treatment, the mean OHIP scores for MC-RPD, TR-RPD, and CPD were 30.57 ± 4.09, 20.71 ± 4.03, and 22.36 ± 2.92, respectively, with CPD showing the greatest improvement. Patient satisfaction was highest for CPD, followed by TR-RPD, and least for MC-RPD. However, satisfaction differences between the groups were not statistically significant after three months.</div></div><div><h3>Conclusion</h3><div>This study highlights the superior performance of CPDs in enhancing OHRQoL and patient satisfaction, though their higher cost may limit accessibility. These findings provide valuable insights for dental practitioners and patients in selecting the most suitable and cost-effective RPD treatment options.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 240-245"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element stress analysis to evaluate and compare the effect of splinting in periodontally compromised teeth having 55 % bone loss with different materials","authors":"Shivangi Joshi,&nbsp;Prakash Talreja,&nbsp;Prajakta Rao,&nbsp;Nilesh Joshi,&nbsp;Vinayak Thorat,&nbsp;Ruhi Mohta","doi":"10.1016/j.jobcr.2025.01.011","DOIUrl":"10.1016/j.jobcr.2025.01.011","url":null,"abstract":"<div><h3>Background</h3><div>Splinting is commonly employed to stabilize periodontally compromised teeth, but the choice of splint material significantly influences stress distribution within the periodontal ligament (PDL) and surrounding bone. This study aimed to evaluate and compare the stress distribution of four different splint materials—composite, fiber-reinforced composite (FRC), polyetheretherketone (PEEK), and metal—on mandibular anterior teeth with 55 % bone loss using finite element analysis (FEA).</div></div><div><h3>Methodology</h3><div>Finite element models of mandibular anterior teeth with 55 % bone loss were developed using SOLIDWORKS 2020. Simulations were conducted for non-splinted teeth and for teeth splinted with composite, FRC, PEEK, and metal. Stress analysis was performed in ANSYS software under vertical (100N at 0°) and oblique (100N at 45°) loading conditions. Von Mises stress values in the PDL and cortical bone were recorded and statistically analyzed using MedCalc software to compare the performance of different splint materials.</div></div><div><h3>Results</h3><div>Non-splinted teeth exhibited the highest stress levels, particularly under oblique loading conditions. Among the splinting materials, FRC showed the most effective reduction in stress across all teeth, especially under vertical loads. Composite and metal wire splints provided moderate stress reduction, with performance varying depending on the load angle. PEEK splints demonstrated good stress reduction under vertical loads but showed increased stress levels under oblique forces. These results underscore the influence of splint material and load direction on stress distribution in periodontally compromised teeth.</div></div><div><h3>Conclusion</h3><div>The study highlights the critical role of splint material in reducing stress on the PDL of periodontally compromised teeth. FRC splints emerged as the most effective material for minimizing stress under both vertical and oblique loading conditions. Composite and metal wire splints offered moderate efficacy, while PEEK splints were less effective under oblique loads. These findings provide valuable insights for clinicians in selecting optimal splint materials for periodontal stabilization.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 250-255"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of upper airway airflow dynamics in young adults with isolated Robin sequence: An exploratory investigation","authors":"Maria Noel Marzano-Rodrigues ,&nbsp;Sergio Henrique Kiemle Trindade ,&nbsp;Ivy Kiemle Trindade-Suedam","doi":"10.1016/j.jobcr.2025.01.009","DOIUrl":"10.1016/j.jobcr.2025.01.009","url":null,"abstract":"<div><div>Impaired upper airway dimension in adults with Isolated Robin Sequence (IRS) can alter airflow dynamics, increasing the risk of pharyngeal collapse and the onset of obstructive sleep apnea. This study aimed to characterize the upper airways of six young adults (20.83 ± 6.40 years) with IRS, using computational fluid dynamics. Upper airways of six patients were reconstructed using 3D segmentation, generating unstructured hybrid meshes with ≥4 million tetrahedral elements. Flow simulations at 15 l/min were solved using the realizable k-ε model and the finite volume method. Morphophysiological variables assessed were: total airway volumes, minimal cross-sectional areas, average pressure, velocity magnitude, wall shear stress, turbulent kinetic energy (k) production, and resistance. Airway volume corresponded to 29.32 ± 4.65 cm³ and minimal cross-sectional area was 1.00 ± 0.55 cm². Pressure drop, airway resistance to airflow, velocity of the airflow and turbulent kinetic energy corresponded to 31.341 ± 15.837 Pa, 0.125 ± 0.063 (Pa s/ml), 1.882 ± 0.514 (m/s) and 0.152 ± 0.056 (m2/s2). The total airway volume exhibited a strong negative correlation with airway resistance (−0.899) and the inlet-to-outlet pressure drop (−0.899). The minimal cross-sectional area of the pharynx at the retroglossal level showed a strong negative correlation (−0.912) with the area-weighted average velocity magnitude of the airflow and with k production (−0.924). In conclusion, airway volume reduction and retroglossal obstruction in young adults with IRS are associated with altered fluid flow characteristics, including increased velocity magnitude, pressure drop, resistance, and turbulent kinetic energy production. These changes may increase the effort to breathe and predispose patients to sleep-disordered breathing.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 234-239"},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of inflammatory biomarkers as a diagnostic tool in peri-implantitis","authors":"Ayan Saxena ,&nbsp;Pavitra Kumar Rastogi ,&nbsp;Nand Lal ,&nbsp;Umesh Pratap Verma ,&nbsp;Rameshwari Singhal ,&nbsp;Md. Kaleem Ahmad","doi":"10.1016/j.jobcr.2025.01.015","DOIUrl":"10.1016/j.jobcr.2025.01.015","url":null,"abstract":"<div><h3>Background</h3><div>Most studies have analyzed the presence of cytokines in Gingival crevicular fluid (GCF) in different periodontal diseases, but very limited studies have been conducted on Peri-implant crevicular fluid (PICF) in peri-implantitis.</div></div><div><h3>Aim</h3><div>The present study was conceptualized to explore the levels of Interleukin (IL)-1β and Interleukin (IL)-6 as a diagnostic marker in peri-implantitis.</div></div><div><h3>Materials and methods</h3><div>A total of 40 patients each having at least one dental implant were enrolled in the study. Clinical parameters were recorded around each implant and tooth nearest to it. Gingival crevicular fluid (GCF)/Peri-implant crevicular fluid (PICF) was collected to evaluate the concentration of IL‐1β and IL‐6. Conservative treatment was performed in peri-implantitis cases, 3 months after treatment their clinical parameters, IL-1β and IL-6 levels were recorded and compared with their pre-treatment values.</div></div><div><h3>Results</h3><div>Clinical parameters like Modified Plaque Index (MPI), Modified Bleeding Index (MBI) and Probing Pocket Depth (PPD) were statistically significantly higher in the peri-implantitis group as compared to the healthy implant group and healthy teeth group. IL-1β and IL-6 levels were also statistically significantly higher in the peri-implantitis group in comparison to healthy implants and healthy teeth group.</div></div><div><h3>Conclusion</h3><div>The study concludes that biomarkers in PICF can be used as a diagnostic tool to supplement the diagnosis of peri-implantitis along with the use of clinical parameters to make an early diagnosis of peri-implantitis possible.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 228-233"},"PeriodicalIF":0.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT–A double-blinded, randomized placebo-controlled trial","authors":"Dr Sana Fatima ,&nbsp;Dr Sonali Taneja ,&nbsp;Dr Vivek Aggarwal ,&nbsp;Dr Akriti Dheer ,&nbsp;Dr Punya Taneja","doi":"10.1016/j.jobcr.2025.01.005","DOIUrl":"10.1016/j.jobcr.2025.01.005","url":null,"abstract":"<div><h3>Aim</h3><div>This study designed to evaluate the effect of adjuvant therapies on the intensity of post-treatment pain after single-visit RCT in molars with symptomatic apical periodontitis.</div></div><div><h3>Method</h3><div>ology: This trial was reported according PRIRATE 2020 guidelines and registered with CTRI/2019/03/018,153.100 patients diagnosed with symptomatic apical periodontitis with a preoperative pain allocated to 4 groups,Group-1: placebo,Group-2:Intraligamentary injection of dexamethasone, Group-3:cryotherapy, Group-4: laser therapy. Patients were instructed to record postoperative pain intensity and intake of analgesics after 6,12,24,48 &amp; 72 h. Intergroup pain intensity was tested by using the Kruskal-Wallis test. The need for painkillers between groups was analyzed using Chi-square test. P value of &lt;0.05 was considered statistically significant.</div><div>R<strong>esults</strong>: Patients in the placebo group exhibited higher intensity. Group 3 showed lesser pain at all-time intervals.</div></div><div><h3>Conclusion</h3><div>All the adjuvant pain management therapies reduced the intensity of postoperative pain and the frequency of intake of analgesics.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 221-227"},"PeriodicalIF":0.0,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced deep learning techniques for recognition of dental implants","authors":"Veena Benakatti ,&nbsp;Ramesh P. Nayakar ,&nbsp;Mallikarjun Anandhalli ,&nbsp;Rohit sukhasare","doi":"10.1016/j.jobcr.2025.01.016","DOIUrl":"10.1016/j.jobcr.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Dental implants are the most accepted prosthetic alternative for missing teeth. With growing demands, several manufacturers have entered the market and produce a variety of implant brands creating a challenge for clinicians to identify the implant when the necessity arises. Currently, radiographs are the only tools for implant identification which is inherently a complex process, hence the need for implant identification technique. Artificial intelligence capable of analysing images in a radiograph and predicting implant type is an efficient tool. The study evaluated an advanced deep learning technique, DEtection TRanformer for implant identification.</div></div><div><h3>Methods</h3><div>A transformer-based deep learning technique, DEtection TRanformer was trained to identify implants in radiographs. A dataset of 1138 images consisting of five implant types captured from periapical and panoramic radiographs was chosen for the study. After augmentation, a dataset of 1744 images was secured and then split into training, validation and test datasets for the model. The model was trained and evaluated for its performance.</div></div><div><h3>Results</h3><div>The model achieved an overall precision of 0.83 and a recall score of 0.89. The model achieved an F1-score of 0.82 indicating a strong balance between recall and precision. The Precision-Recall Curve, with an AUC of 0.96, showed that the model performed well across various thresholds. The training and validation graphs showed a consistent decrease in the loss functions across classes.</div></div><div><h3>Conclusion</h3><div>The model showed high performance on the training data, though it faced challenges with unseen validation data. High precision, recall and F1 score indicate the model's potential for implant identification. Optimizing this model for a balance between accuracy and efficiency will be necessary for real-time medical imaging applications.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 2","pages":"Pages 215-220"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharyngeal airway dimensions and adipose distribution in the minipig","authors":"Doris H. Rosero Salazar ,&nbsp;Riana Grewal ,&nbsp;Anuj Vimawala ,&nbsp;Daniel F. Leotta ,&nbsp;Swati R. Levendovszky ,&nbsp;Zi-Jun Liu","doi":"10.1016/j.jobcr.2024.12.004","DOIUrl":"10.1016/j.jobcr.2024.12.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the pharyngeal airway dimensions and regional pharyngeal adipose distribution in the young adult minipig model.</div></div><div><h3>Materials and methods</h3><div>Eight 7-8-months-old Yucatan minipigs, half male and female, were sedated and placed prone to scan the pharyngeal region. Magnetic resonance imaging (MRI) was performed using dynamic turbo-field echo (TFE)-sequence with respiratory gating and adipose-weighted sequence. Respiratory airflow velocity, pressure, and volume were also recorded. The sizes of velopharyngeal and oropharyngeal airway, and retroglossal areas were measured coronally during inspiration and expiration. The airway volumes from the nasal cavity to the retroglossal space were segmented, reconstructed, and evaluated in sagittal views. The adipose distribution in the tongue base, soft palate, pharyngeal wall, tongue body, and masseter muscle (reference) were segmented and measured in sagittal and coronal planes.</div></div><div><h3>Results</h3><div>The velopharyngeal and oropharyngeal areas were larger in inspiration than in expiration. These areas were also larger than that in the retroglossal space (p &lt; 0.05). The nasal cavity showed a larger volume than that of the pharyngeal regions (p &lt; 0.05). The adipose distribution was larger in the posterior region of the tongue base and anterior soft palate, both larger than the masseter muscle (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The larger oropharyngeal dimensions and increased adipose distribution in the tongue base contribute to the functional morphology of the pharyngeal airway in the healthy minipig. These data provide the baseline for further analysis in enlarged and reduced tongue base minipig models.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 77-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of remineralizing potential of four enamel remineralising agents using SEM-EDX – An in-vitro study","authors":"R. Raj","doi":"10.1016/j.jobcr.2025.01.006","DOIUrl":"10.1016/j.jobcr.2025.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>Compare the remineralisation potential of four enamel remineralising agents on artificially demineralized enamel surface using Scanning electron microscopy- Energy dispersive x-ray.</div></div><div><h3>Materials and methods</h3><div>75 extracted maxillary and mandibular premolars coated with acid-resistant nail varnish, were stored in demineralising solution for 96 h to produce artificial caries lesions. The samples were divided into 5 groups (n = 15), Control (Demineralized- No treatment), Group I samples were treated with casein phosphoprotein-amorphous calcium phosphate (CPP-ACP), Group II with self-assembling peptide (SAP-14), Group III with tri-calcium phosphate (f-TCP) and Group IV with Bioactive glass (BAG), respectively. The pH cycling model was followed for 21 days. The samples were analysed via SEM-EDX (Carl Zeiss, Germany; Model: Merlin Compact) for qualitative assessment and quantitative analysis of calcium and phosphorous. The data were analysed for multiple group comparison using IBM SPSS version 20 with one-way ANOVA followed by a paired <em>t</em>-test.</div></div><div><h3>Results</h3><div>Calcium/Phosphorous ratio of all experimental groups; Group 1(1.92 ± .17), Group 2 (1.98 ± .16), Group 3 (1.81 ± .03), Group 4 (1.75 ± .08) was statistically different (p &lt; 0.0005) from Control; while there was no difference between Group I and Group II (p = 0.33).</div></div><div><h3>Conclusion</h3><div>All experimental groups showed comparable remineralising potential. Even though no statistically significant difference is seen between Group I and Group II, after correlating with surface analysis it was concluded that Group II showed the greatest remineralising potential.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 183-187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}