透明质酸与羊膜在拔牙窝伤口愈合和骨再生中的作用——一项随机对照试验

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-02-11 DOI:10.1016/j.jobcr.2025.01.027

Abinav Sundar T. , Pratiksha Shetty , Padmaraj Hegde , Shreya S.

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引用次数: 0

摘要

背景：手术切除阻生第三磨牙是口腔外科的常规手术，经常伴有各种影响伤口愈合的并发症。透明质酸（HA）和冻干羊膜（AM）已被证明具有促进伤口愈合和骨再生的潜力。这些可以帮助拔牙窝脱臼后的愈合。目的观察0.2% HA凝胶和2.5 × 2.5 cm AM对下颌第三磨牙拔牙槽内创面愈合和骨再生的影响。材料和方法根据纳入和排除标准对45例患者进行临床和影像学评估，并通过抽签法随机分为3组：1组，对照组，2组，AM组和3组，HA。疼痛评分采用视觉模拟评分法。在三个不同的时间间隔评估面部肿胀、咬合和骨再生的程度。结果对照组与研究组疼痛评分差异有统计学意义（p < 0.05）。各组患者面部肿胀、咬合程度差异有统计学意义（p < 0.05）。2组术后第3个月骨小梁形成水平明显改善（p < 0.05）。结论羟基磷灰石和AM在改善下颌第三磨牙术后疼痛、伤口愈合和整体骨再生方面具有潜在的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hyaluronic acid versus amniotic membrane in wound healing and bone regeneration in extraction sockets - A randomized controlled trial

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Hyaluronic acid versus amniotic membrane in wound healing and bone regeneration in extraction sockets - A randomized controlled trial

Background

Surgical removal of the impacted third molar is a routinely employed procedure in oral surgery, often associated with various complications which affect wound healing. Hyaluronic acid (HA) and freeze-dried (lyophilized) amniotic membrane (AM) have demonstrated the potential to promote wound healing and bone regeneration. These could aid in the healing of the extraction socket post-disimpaction.

Objectives

To assess the extent of wound healing and bone regeneration in extraction sockets of surgically removed mandibular third molars following intra-socket application of 0.2 % HA gel and 2.5 × 2.5 cm of AM.

Material and methods

45 patients were clinically and radiographically evaluated based on the inclusion and exclusion criteria and were randomized by lottery method into three groups – Group 1, control, Group 2, AM, and Group 3, HA. The pain scores were evaluated using the visual analog scale. The extent of facial swelling, trismus and bone regeneration were assessed at three different time intervals.

Results

A significant difference (p<0.05) in the pain score was observed between the control group and the study groups. The extent of facial swelling and trismus observed was of significance within the groups (p<0.05). Group 2 exhibited significantly improved levels of trabecular bone formation at the third post-operative month (p<0.05).

Conclusion

HA and AM could be potentially useful in improving the post-operative sequelae following surgical removal of mandibular third molars in terms of pain, wound healing, and overall bone regeneration.

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.