The evaluation of periodontal ligament cell viability for an avulsed tooth using various storage media: A systematic review and meta-analysis

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-07-31 DOI:10.1016/j.jobcr.2025.07.020

Anushka Gayan , T.R. Chaitra , Seema Chaudhary , T.L. Ravishankar , Supinder Sudan , Bornisha Bezborah

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引用次数: 0

Abstract

Background

Many storage mediums are available for the storage of avulsed teeth to preserve the viability of periodontal ligament (PDL) cells before replantation; however, it is unclear which medium is the optimal option.

Aim

This systematic review and meta-analysis (MA) aimed to evaluate the effectiveness of various storage media in preserving the viability of periodontal ligament (PDL) cells, using Hank's Balanced Salt Solution (HBSS) as a reference standard for comparison.

Review method

This systematic review was performed according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. The database including Medline (via. PUBMED), Scopus, The Cochrane Controlled Clinical trials Register, Google scholar were thoroughly searched from 2014 to 2024. The reference articles which have been retrived were exported to Mendeley Desktop software 1.13.3.43.

Result

HBSS medium did not show significant difference in cell viability when compared with placentrix (Mean difference: 0.56, 95 % CI(-5.64,-0.04), p = 0.05, I2 = 96 %), whereas aloevera showed superior cell viability compared to HBSS. Conclusion: This systematic review and MA suggests that placentrex and aloevera could represent an alternative to HBSS. However, more studies are necessary to obtain a reliable conclusion.

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不同储存介质对撕脱牙牙周韧带细胞活力的评估：一项系统回顾和荟萃分析

为了在再植前保持牙周韧带（PDL）细胞的活力，有许多储存介质可用于保存撕脱牙；然而，目前尚不清楚哪种媒介是最佳选择。目的以汉克平衡盐溶液（Hank’s Balanced Salt Solution， HBSS）为对照标准，评价不同储存介质对牙周韧带（periodontal ligament， PDL）细胞存活能力的保护效果。本系统评价按照PRISMA（系统评价和荟萃分析首选报告项目）指南进行。数据库包括Medline(通过。PUBMED), Scopus, The Cochrane Controlled Clinical trials Register， b谷歌学者从2014年到2024年进行了全面检索。将检索到的参考文献导出到Mendeley Desktop软件1.13.3.43中。结果与胎盘相比，bss培养液的细胞活力差异无统计学意义（平均差异为0.56,95% CI(-5.64,-0.04), p = 0.05, I2 = 96%），芦荟培养液的细胞活力优于HBSS。结论：本系统综述和MA表明，胎盘和芦荟可作为HBSS的替代方案。然而，需要更多的研究才能得出可靠的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.