{"title":"探索植物来源的碳点:用于牙髓感染和增强生物成像的双功能纳米材料","authors":"Malavika Pradeep , Anju Cecil , Nidhita Suresh , Rajakumar Govindasamy , Natesan Thirumalaivasan","doi":"10.1016/j.jobcr.2025.08.030","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Endodontic infections are a major problem of public health, which requires new therapeutic and diagnostic approaches. Carbon dots (CDs) derived from natural sources have great potential as nanomaterials because of their exceptional properties, including biocompatibility and photoluminescence.</div></div><div><h3>Aim</h3><div>An investigation into the therapeutic possibilities of carbon dots derived from long pepper leaves(LCDs) for treating endodontic infections and parallel bio-imaging functionality forms the core research objective.</div></div><div><h3>Method</h3><div>LCDs through a hydrothermal process and checked their properties with FTIR, SEM-EDX, and fluorescence equipment. They tested the cells' acceptance of LCDs along with their resistance to bacteria and ability to enter cells using fibroblast growth tests, the <em>Streptococcus mutans</em> bacteria test, and microscope imaging.</div></div><div><h3>Results</h3><div>LCDs promoted better fibroblast development and endodontic infections healing above previous treatment standards. Biopsy tests show that LCD material kills <em>Streptococcus mutans</em> bacteria easily while also readily up taking cells for potential for Bio-imaging.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that LCD types serve both as a medication for endodontic infections repair and a tool for living tissue observation. we have found a novel approach that will bring new possibilities to both managing endodontic infections and medical imaging techniques.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 6","pages":"Pages 1408-1414"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring plant-derived carbon dots: Dual-functional nanomaterials for endodontic infections and enhanced bio-imaging\",\"authors\":\"Malavika Pradeep , Anju Cecil , Nidhita Suresh , Rajakumar Govindasamy , Natesan Thirumalaivasan\",\"doi\":\"10.1016/j.jobcr.2025.08.030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Endodontic infections are a major problem of public health, which requires new therapeutic and diagnostic approaches. Carbon dots (CDs) derived from natural sources have great potential as nanomaterials because of their exceptional properties, including biocompatibility and photoluminescence.</div></div><div><h3>Aim</h3><div>An investigation into the therapeutic possibilities of carbon dots derived from long pepper leaves(LCDs) for treating endodontic infections and parallel bio-imaging functionality forms the core research objective.</div></div><div><h3>Method</h3><div>LCDs through a hydrothermal process and checked their properties with FTIR, SEM-EDX, and fluorescence equipment. They tested the cells' acceptance of LCDs along with their resistance to bacteria and ability to enter cells using fibroblast growth tests, the <em>Streptococcus mutans</em> bacteria test, and microscope imaging.</div></div><div><h3>Results</h3><div>LCDs promoted better fibroblast development and endodontic infections healing above previous treatment standards. Biopsy tests show that LCD material kills <em>Streptococcus mutans</em> bacteria easily while also readily up taking cells for potential for Bio-imaging.</div></div><div><h3>Conclusion</h3><div>The study demonstrates that LCD types serve both as a medication for endodontic infections repair and a tool for living tissue observation. we have found a novel approach that will bring new possibilities to both managing endodontic infections and medical imaging techniques.</div></div>\",\"PeriodicalId\":16609,\"journal\":{\"name\":\"Journal of oral biology and craniofacial research\",\"volume\":\"15 6\",\"pages\":\"Pages 1408-1414\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of oral biology and craniofacial research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S221242682500209X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221242682500209X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Exploring plant-derived carbon dots: Dual-functional nanomaterials for endodontic infections and enhanced bio-imaging
Background
Endodontic infections are a major problem of public health, which requires new therapeutic and diagnostic approaches. Carbon dots (CDs) derived from natural sources have great potential as nanomaterials because of their exceptional properties, including biocompatibility and photoluminescence.
Aim
An investigation into the therapeutic possibilities of carbon dots derived from long pepper leaves(LCDs) for treating endodontic infections and parallel bio-imaging functionality forms the core research objective.
Method
LCDs through a hydrothermal process and checked their properties with FTIR, SEM-EDX, and fluorescence equipment. They tested the cells' acceptance of LCDs along with their resistance to bacteria and ability to enter cells using fibroblast growth tests, the Streptococcus mutans bacteria test, and microscope imaging.
Results
LCDs promoted better fibroblast development and endodontic infections healing above previous treatment standards. Biopsy tests show that LCD material kills Streptococcus mutans bacteria easily while also readily up taking cells for potential for Bio-imaging.
Conclusion
The study demonstrates that LCD types serve both as a medication for endodontic infections repair and a tool for living tissue observation. we have found a novel approach that will bring new possibilities to both managing endodontic infections and medical imaging techniques.
期刊介绍:
Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.