Journal of musculoskeletal & neuronal interactions最新文献

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Effects of a 6-Week Home-Based High- or Regular-Volume Static Stretching or Hamstring Resistance Exercise in Young Men with Hamstring Tightness. 6周基于家庭的高或常规量静态拉伸或腿筋阻力运动对腿筋紧绷的年轻男性的影响。
IF 1.9 4区 医学
Nongnuch Luangpon, Wirasinee Srijunto, Sirawee Chaovalit, Mac Thi Luu, Nutsupa Singhasoot, Supparada Aewzipo, Saule Salatkaite-Urbone, Sigitas Kamandulis, Pornpimol Muanjai
{"title":"Effects of a 6-Week Home-Based High- or Regular-Volume Static Stretching or Hamstring Resistance Exercise in Young Men with Hamstring Tightness.","authors":"Nongnuch Luangpon, Wirasinee Srijunto, Sirawee Chaovalit, Mac Thi Luu, Nutsupa Singhasoot, Supparada Aewzipo, Saule Salatkaite-Urbone, Sigitas Kamandulis, Pornpimol Muanjai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to examine the effects of unilateral long-duration static stretching (LS) on range of motion (ROM), musculotendinous unit (MTU) stiffness, muscle thickness (MT), strength, and contralateral effects (CE) in young men with hamstring tightness.</p><p><strong>Methods: </strong>Sixty-eight young men (22.0 ± 1.7 years) were randomly assigned to one of four groups: LS, typical-duration static stretching (SS), hamstring resistance exercise (HRE), or control. ROM, MTU stiffness, MT, and knee-flexor peak torque were assessed at baseline, after the 6-week intervention, and at the 3-month follow-up.</p><p><strong>Results: </strong>ROM improvement after the 6-week was observed across the LS, SS, and HRE groups (all p<0.05). Significant decreases in MTU stiffness were observed, with reductions of 0.13 Nm/deg in the hamstrings for both the stretching groups (all p<0.05). At the 3-month follow-up, reductions in MTU stiffness remained evident in the LS group. A significant time effect was observed for bilateral peak torque without interaction or group effects, while MT showed no changes.</p><p><strong>Conclusions: </strong>One hour of hamstring stretching did not result in superior improvements in ROM, MTU stiffness, or morphological and CE adaptations compared to other exercise modalities. Nevertheless, SS remains a time-efficient approach to enhance flexibility and mechanical properties in a home-based setting.</p><p><strong>Clinical trial registration: </strong>Thai Clinical Trials Registry (TCTR20250219007).</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"181-191"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avascular Necrosis of the Femoral Head Following Posterior Hip Dislocation in an Adolescent. 一例青少年髋后脱位后股骨头缺血性坏死。
IF 1.9 4区 医学
Symeon Naoum, Christos Koutserimpas, Amr ElKhouly, Neville C Davies, Evdokia Billis, Maria Piagkou, Charalampos Matzaroglou, Efstathios Chronopoulos
{"title":"Avascular Necrosis of the Femoral Head Following Posterior Hip Dislocation in an Adolescent.","authors":"Symeon Naoum, Christos Koutserimpas, Amr ElKhouly, Neville C Davies, Evdokia Billis, Maria Piagkou, Charalampos Matzaroglou, Efstathios Chronopoulos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"311-315"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of an Eight-Week Proprioceptive Neuromuscular Facilitation (PNF) Stretching Intervention on Functional Movement Patterns in Female Basketball Players: Randomized Controlled Trial. 8周本体感觉神经肌肉促进(PNF)拉伸干预对女篮球运动员功能性运动模式的影响:随机对照试验。
IF 1.9 4区 医学
Yusuf Gözaçık, Hasan Aykut Aysan
{"title":"Effects of an Eight-Week Proprioceptive Neuromuscular Facilitation (PNF) Stretching Intervention on Functional Movement Patterns in Female Basketball Players: Randomized Controlled Trial.","authors":"Yusuf Gözaçık, Hasan Aykut Aysan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the effects of proprioceptive neuromuscular facilitation (PNF) stretching exercises on functional movement performance in female basketball players.</p><p><strong>Methods: </strong>A pre-test/post-test experimental design with intervention and control groups was used. Participants who met the inclusion criteria were randomly allocated to the experimental and control groups in a 1:1 ratio. The experimental group performed PNF stretching exercises in addition to their regular training program, three days per week for eight weeks, while the control group continued with standard training only. Functional movement performance was assessed using the Functional Movement Screen (FMS), with individual FMS subtests analyzed, and all assessments were conducted by a blinded assessor.</p><p><strong>Results: </strong>Within-group improvements were observed in several FMS subtests in the experimental group (p < 0.05), particularly in measures related to lower-extremity stability, balance, and movement coordination, while no significant changes were found in the control group. Between-group comparisons of change scores (Δ post-pre) demonstrated significantly greater improvements in the experimental group for selected FMS subtests, indicating a beneficial effect of PNF stretching.</p><p><strong>Conclusion: </strong>PNF stretching exercises appear to be an effective method for enhancing specific components of functional movement performance in female basketball players. Incorporating PNF-based stretching into regular training programs may contribute to improvements in selected movement quality and performance outcomes.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"202-212"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Sensory- Motor Integration Training on Activities of Daily Living in Children with Erb's Palsy: A Randomized Controlled Trial. 感觉-运动整合训练对Erb's麻痹儿童日常生活活动的影响:一项随机对照试验。
IF 1.9 4区 医学
Sara E Ali, Abd Elaziz A Sherif, Osama A El-Agamy, Monira I Aldhahi, Sara Y Elsebahy
{"title":"Effect of Sensory- Motor Integration Training on Activities of Daily Living in Children with Erb's Palsy: A Randomized Controlled Trial.","authors":"Sara E Ali, Abd Elaziz A Sherif, Osama A El-Agamy, Monira I Aldhahi, Sara Y Elsebahy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study examined sensory-motor integration training effects on activities of daily living (ADLs) in children with Erb's palsy.</p><p><strong>Methods: </strong>A randomized controlled trial enrolled 32 children aged 2-6 years with Narakas Type I Erb's palsy. This assessor-blinded study randomly allocated participants using sequentially numbered, sealed opaque envelopes to control group (60 minutes of an upper-limb rehabilitation program) or study group (45 minutes of the same upper-limb rehabilitation program plus 15 minutes of sensory-motor integration training; total 60 minutes/session). Interventions were delivered three times weekly for 12 weeks. The primary outcome was the Jebsen-Taylor Hand Function Test (JTHFT) Simulated Feeding subtest; secondary outcomes included other JTHFT subtests and grip strength, measured at baseline and week 12.</p><p><strong>Results: </strong>Both groups showed significant within-group improvements in grip strength (p < 0.001). Post-intervention, the study group demonstrated significantly greater grip strength versus control (5.42 ± 0.81 vs. 3.36 ± 0.46), with a between-group difference of 2.06 units (95% CI: 1.58-2.54) and very large effect size (Cohen's d = 3.13; p < 0.001). The study group showed greater improvement in feeding performance (Δ = 13.93 s; 60% improvement) than control (Δ = 11.27 s; 51% improvement).</p><p><strong>Conclusion: </strong>Combined with an upper limb rehabilitation program, sensory-motor integration training significantly improves functional abilities and daily living skills in children with Erb's palsy.</p><p><strong>Clinicaltrials: </strong>gov ID: NCT06324643.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"273-284"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Blood Creatine Kinase and Muscle Damage in Speed Skaters. 速滑运动员血肌酸激酶与肌肉损伤的关系。
IF 1.9 4区 医学
Takanori Matsuura, Masaki Yamaguchi, Koichiro Kuwahara, Koji Yoshie, Yukari Okuma, Masahiro Yuki
{"title":"Relationship Between Blood Creatine Kinase and Muscle Damage in Speed Skaters.","authors":"Takanori Matsuura, Masaki Yamaguchi, Koichiro Kuwahara, Koji Yoshie, Yukari Okuma, Masahiro Yuki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore whether resting creatine kinase (CK) levels are associated with a combination of commonly used psychophysiological parameters in speed skaters. Speed skaters were regarded as ideal candidates for this study, considering the sport's high incidence of muscle damage.</p><p><strong>Methods: </strong>Participants consisted of nine speed skaters, including international-level competitors, and nine non-athletes who served as controls. Measurements included CK, ferritin (Fer), perceived fatigue level (PFL), sleep quality assessment (SQA), international physical activity questionnaire (IPAQ), pulse rate, blood pressure, physical activity, thigh circumference, handgrip strength, and jump height. A multiple regression analysis was performed with CK as the dependent variable and the other psychophysiological parameters as independent variables.</p><p><strong>Results: </strong>CK, IPAQ, thigh circumference, and jump height were significantly higher in speed skaters (p < 0.05), whereas pulse rate and PFL were significantly lower (p < 0.05). In an exploratory multiple regression analysis, a combination of pulse rate, mean arterial pressure, PFL, and SQA showed the highest coefficient of determination (R2 = 0.54), suggesting that these variables may be associated with inter-individual variation in resting CK levels.</p><p><strong>Conclusion: </strong>The combination of conventional psychophysiological parameters was associated with variation in CK levels. These findings provide preliminary evidence that CK may be a plausible biomarker of muscle damage in elite speed skaters.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"192-201"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthrogenic Muscle Inhibition: A Study on the Correlation Between Neuromuscular Dysfunction and Mobility limitations Following Cruciate Ligament Reconstruction Surgery. 关节源性肌肉抑制:交叉韧带重建术后神经肌肉功能障碍与活动受限的相关性研究。
IF 1.9 4区 医学
JingYao Jiang, DongLiang Zhang, HongFeng Ye, TianXiong Qiu, JunFeng Zhu, ZhenXing Zhang
{"title":"Arthrogenic Muscle Inhibition: A Study on the Correlation Between Neuromuscular Dysfunction and Mobility limitations Following Cruciate Ligament Reconstruction Surgery.","authors":"JingYao Jiang, DongLiang Zhang, HongFeng Ye, TianXiong Qiu, JunFeng Zhu, ZhenXing Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To explore arthrogenic muscle inhibition (AMI)'s impact on mobility after anterior/posterior cruciate ligament (ACL/PCL) reconstruction, identify early predictors of postoperative stiffness, and inform clinical rehabilitation.</p><p><strong>Methods: </strong>In this prospective cohort study, 146 ACL/PCL reconstruction patients were split into stiff (passive flexion <120° and extension deficit >5° at 12 weeks [T2]) and non-stiff groups. Preoperative data, knee function (ROM, gait, muscle strength, proprioception) and AMI indicators (quadriceps VA, H/M ratio) were assessed at 4 weeks (T1) and T2. Boruta, multivariate logistic, and multiple linear regression analyzed predictors.</p><p><strong>Results: </strong>The stiff group had longer injury-to-surgery intervals, higher patellar tendon use, worse ROM/gait/strength/AMI metrics at T1-T2. The four most important predictors for T2 stiffness were T1 passive flexion, extension deficit, H/M ratio, and VA; T1 H/M (OR = 4.82) and extension deficit (OR = 3.85) were major risks. T2 H/M correlated negatively with passive flexion (β = -0.73), T1 VA with extension deficit (β = -0.38). The logistic model demonstrated good predictive performance (optimism-corrected C-index = 0.890).</p><p><strong>Conclusions: </strong>AMI associates with post-ACL/PCL mobility issues. Four early indicators predict T2 stiffness, with H/M impacting flexion and VA affecting extension, guiding personalized rehabilitation.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"259-272"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does a Validated Circum-menarcheal Arm Bone-Loading Index Predict Post-menarcheal Muscle Function in Adolescent Females? 经验证的环月经露脊臂骨负荷指数能否预测青春期女性月经露脊后的肌肉功能?
IF 1.9 4区 医学
Brian Josephson, Timothy Chan, Carol A Sames, Tamara A Scerpella, Jodi N Dowthwaite
{"title":"Does a Validated Circum-menarcheal Arm Bone-Loading Index Predict Post-menarcheal Muscle Function in Adolescent Females?","authors":"Brian Josephson, Timothy Chan, Carol A Sames, Tamara A Scerpella, Jodi N Dowthwaite","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>In this exploratory analysis, we evaluated our validated 3-year circum-menarcheal arm bone loading index (ᴀʀᴍBLI) as a predictor of upper extremity muscle function indices in post-menarcheal females.</p><p><strong>Methods: </strong>Forty-eight participants met inclusion criteria for non-dominant arm analyses, 1 to 2.5 years post-menarche: 1) menarche date (ɢʏɴAGE: yrs, menarche-centered age); 2) ᴀʀᴍBLI (3-yrs prior loading exposure); 2) grip strength (kg; primary outcome), 3) Biodex peak torques (Nm: shoulder, elbow; flexion, extension; secondary outcomes), 4) DXA arm non-bone fat-free mass (ᴀʀᴍNBꜰꜰᴍ, kg), 5) anthropometry [ulna length (mm), height (cm), weight (kg)]. Multiple linear regression evaluated muscle function in the total sample (n=48), gymnasts (n=24), and non-gymnasts (n=24), accounting for key factors: 1) whole-body model (ɢʏɴAGE, height, weight, ᴀʀᴍBLI); 2) hypertrophy model (ɢʏɴAGE, ulna length, ᴀʀᴍNBꜰꜰᴍ, ᴀʀᴍBLI).</p><p><strong>Results: </strong>After accounting for key factors, ᴀʀᴍBLI was an independent negative predictor of grip strength in the total sample [hypertrophy model B= -0.202, p=0.029] and non-gymnast subsample [hypertrophy model B= -0.935, p=0.030; whole-body model B= -1.127, p=0.005]. Conversely, ᴀʀᴍBLI was an independent positive predictor of shoulder flexion peak torque in the total sample [whole-body model B= +0.270, p=0.036].</p><p><strong>Conclusions: </strong>Despite prior work showing ᴀʀᴍBLI predicts ᴀʀᴍNBꜰꜰᴍ, ᴀʀᴍBLI showed inconsistent predictive value for muscle function indices.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"165-180"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of miR-27a in Patients with Steroid-associated Femoral Head Osteonecrosis and Its Regulatory Mechanism on Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells. miR-27a在类固醇相关性股骨头坏死患者中的表达及其对骨髓间充质干细胞增殖和成骨分化的调控机制
IF 1.9 4区 医学
Zhiqing Chen, Min Wang, Zepei Zhang, Chun Zhang, Yuzhe Cao, Shaoming Liu, Shuzhang Guo, Jun Miao
{"title":"Expression of miR-27a in Patients with Steroid-associated Femoral Head Osteonecrosis and Its Regulatory Mechanism on Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.","authors":"Zhiqing Chen, Min Wang, Zepei Zhang, Chun Zhang, Yuzhe Cao, Shaoming Liu, Shuzhang Guo, Jun Miao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the expression of microRNA-27a (miR-27a) in patients with steroid-associated femoral head osteonecrosis (SAN) and its regulatory effects on bone marrow mesenchymal stem cells (BMSCs).</p><p><strong>Methods: </strong>The expression levels of miR-27a and the osteogenic-related genes Runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 2 (BMP-2) were measured in bone marrow samples from SAN patients and controls. Human BMSCs were cultured <i>in vitro</i> and divided into four groups: blank control group, mimic negative control (mimic NC) group, miR-27a mimic group, and miR-27a inhibitor group. Cell proliferation, osteogenic differentiation, and expression of osteogenic-related genes were assessed.</p><p><strong>Results: </strong>The relative expression levels of miR-27a, Runx2, and BMP-2 in bone marrow tissues of the SAN group were significantly lower than those in the control group (all P<0.001). miR-27a expression was positively correlated with Runx2 and BMP-2 expression (P<0.001). Compared with the mimic NC group, the miR-27a mimic group showed increased cell proliferation (OD values), alkaline phosphatase (ALP) activity, number of calcium nodules, and expression levels of Runx2 and BMP-2 (all P<0.05). Compared with the mimic NC group, the miR-27a inhibitor group showed significantly decreased cell proliferation (OD values), ALP activity, number of calcium nodules, and expression levels of Runx2 and BMP-2 (all P<0.05).</p><p><strong>Conclusion: </strong>miR-27a may promote the proliferation and osteogenic differentiation of BMSCs by upregulating Runx2 and BMP-2 and may represent a potential therapeutic target for the treatment of SAN.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"285-292"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astragalus Polysaccharides Attenuate LPS-Induced Degenerative Responses in Primary Rat Chondrocytes linked to the NLRP3/CASPASE-1 Axis. 黄芪多糖可减弱与NLRP3/CASPASE-1轴相关的大鼠原代软骨细胞中lps诱导的退行性反应。
IF 1.9 4区 医学
Xiaowei Jiang, Xin Ye, Taoye Li, Zhengfeng Mei, Yichun Zhang
{"title":"Astragalus Polysaccharides Attenuate LPS-Induced Degenerative Responses in Primary Rat Chondrocytes linked to the NLRP3/CASPASE-1 Axis.","authors":"Xiaowei Jiang, Xin Ye, Taoye Li, Zhengfeng Mei, Yichun Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Cartilage degeneration is a key pathological change in osteoarthritis (OA). This study investigated the mechanism by which Astragalus polysaccharides (APS) alleviate cartilage degeneration.</p><p><strong>Methods: </strong>Primary rat articular chondrocytes were isolated, and a cell degeneration model was induced with lipopolysaccharide (LPS). Different concentrations of APS (100, 200, 400 mg/L) were tested, and NLR family pyrin domain containing 3 (NLRP3)-knockdown chondrocytes were generated. Cell viability (CCK-8 metabolic activity), levels of inflammatory factors, and gene and protein levels of markers associated with cartilage degeneration (including Acan, Adamts5, Nlrp3, and Caspase-1) were measured.</p><p><strong>Results: </strong>APS at different concentrations improved cell viability (CCK-8) of LPS-induced chondrocytes, inhibited the inflammatory cytokines interleukin-1β (IL-1β) and IL-18, upregulated Acan, and downregulated Adamts5, Nlrp3, and Caspase-1. Nlrp3 knockdown produced similar effects to APS, improving chondrocyte degeneration in vitro.</p><p><strong>Conclusion: </strong>APS alleviates LPS-induced degenerative responses in primary rat chondrocytes, and its protective effect is associated with modulation of the NLRP3/CASPASE-1 axis.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"301-310"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary to: Relationship Between Plantar Pressure, Body Mass Index and Balance in Children: A Cross-Sectional Study. 评论:儿童足底压力、体重指数和平衡之间的关系:一项横断面研究。
IF 1.9 4区 医学
Jiayi Chen
{"title":"Commentary to: Relationship Between Plantar Pressure, Body Mass Index and Balance in Children: A Cross-Sectional Study.","authors":"Jiayi Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"316"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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