Journal of musculoskeletal & neuronal interactions最新文献_第4页

Precision Errors of Lower Leg Measurement by pQCT in Children With Medical Conditions: Bone Density, Mass, Dimensions, Mechanostat Parameters and Soft Tissue Composition. 通过 pQCT 对患有疾病的儿童进行小腿测量的精度误差：骨密度、质量、尺寸、力学参数和软组织成分。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-018

Maciej Jaworski, Maria Kobylińska

{"title":"Precision Errors of Lower Leg Measurement by pQCT in Children With Medical Conditions: Bone Density, Mass, Dimensions, Mechanostat Parameters and Soft Tissue Composition.","authors":"Maciej Jaworski, Maria Kobylińska","doi":"10.22540/JMNI-25-018","DOIUrl":"10.22540/JMNI-25-018","url":null,"abstract":"Objectives: The one of the developing methods in paediatric densitometry field is peripheral quantitative computed tomography (pQCT), however, very little is known about its precision in children. The aim of presented study was to evaluate the precision errors for bone density, mass, dimensions, strength and mechanostat parameters as well as for soft tissue composition in children with medical conditions.Methods: Stratec XCT 2000L apparatus was used. The measurement sites were 4%, 14%, 38% and 66% of the lower leg length. The study group comprised of 60 patients (30 girls) aged 5,0-18,0 yrs.Results: Relative precision errors (CV%RMS) were from 0,25% for tibia 38% cortical bone density to 5,49% for fat cross-sectional area to muscle cross-sectional area ratio. Least significant change (LSC) was from 0,70% to 15,20%, respectively. Weak to moderate correlations between precision errors and body size, with r from -0,43 to 0,71, have been observed.Conclusion: Presented study revealed pQCT method at the lower leg in children with medical conditions as relatively precise technique. Obtained results provides an attainable basis for design and interpretation of pQCT studies in children with medical conditions.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"18-28"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Neural Respiratory Drive Using Surface Electromyography Parameters of Parasternal Muscles in Three Different Body Positions Among Healthy Young Adults: A Cross-Sectional Study. 用三种不同体位胸骨旁肌表面肌电图参数评估健康年轻人的神经呼吸驱动：一项横断面研究。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-074

Santosh Wakode, Pooja Salkar, Avinash Thakare, Sandip Hulke, Varun Malhotra, Rekha Jiwne

{"title":"Assessment of Neural Respiratory Drive Using Surface Electromyography Parameters of Parasternal Muscles in Three Different Body Positions Among Healthy Young Adults: A Cross-Sectional Study.","authors":"Santosh Wakode, Pooja Salkar, Avinash Thakare, Sandip Hulke, Varun Malhotra, Rekha Jiwne","doi":"10.22540/JMNI-25-074","DOIUrl":"10.22540/JMNI-25-074","url":null,"abstract":"Objectives: The neural respiratory drive (NRD) is a critical determinant of breathlessness, influenced by the balance between ventilatory load and respiratory muscle capacity. This study aimed to evaluate the impact of body positions on NRD in young healthy adults (18-50 years) and to identify the optimal position for assessing NRD among the healthy subjects.Methods: Surface electromyography (sEMG) data from the 2nd intercostal space parasternal muscle was collected in supine, sitting, and standing positions among young healthy adults. NRD parameters, including EMG Para max% and Neural Respiratory Drive Index (NRDI), were analysed and compared among positions using ANOVA.Results: Significant differences in NRD values were observed across body positions, with standing vs. supine vs. sitting yielding higher values in both sexes respectively (Males: 5.113±0.437, 4.404±0.576, 4.913±0.623; P<0.001 and Females: 7.444±0.416, 6.435±0.266, 6.748±0.390; P<0.001). Post hoc analysis reveals significant difference in standing vs supine vs sitting position. These findings highlight the influence of body position on NRD measurements.Conclusions: The study emphasizes the importance of considering body position when evaluating NRD in healthy individuals. These factors should also be taken into account in clinical assessments to ensure accurate interpretation of NRD and related respiratory functions.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"74-85"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rehabilitation Perspectives in Spinal Cord Ischemia After Major Vascular Surgery: A Case Series. 大血管手术后脊髓缺血的康复前景：病例系列。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-056

Yuya Niki, Pleiades T Inaoka, Etsuko Nishi, Sho Horie, Naoki Mugii, Tetsutaro Yahata, J Luis Espinoza

{"title":"Rehabilitation Perspectives in Spinal Cord Ischemia After Major Vascular Surgery: A Case Series.","authors":"Yuya Niki, Pleiades T Inaoka, Etsuko Nishi, Sho Horie, Naoki Mugii, Tetsutaro Yahata, J Luis Espinoza","doi":"10.22540/JMNI-25-056","DOIUrl":"10.22540/JMNI-25-056","url":null,"abstract":"Objectives: This observational study aims to summarize the disability profile, rehabilitation strategies, and six-month outcomes in patients with Spinal Cord Ischemia (SC-ischemia) following Major Vascular Surgeries (MVS) at our institution.Methods: Retrospective data were collected from seven patients who underwent MVS between April 2016 and March 2020.Results: All patients were male, with a mean age of 68.7 years. SC-ischemia affected predominantly Th10 (six patients) and Th12 (one patient), resulting in severe motor paralysis in six patients and moderate paralysis in one. The average intensive care unit stay was 19.6 days, with delayed mobility observed (9.6 days to sit upright, 14.9 days to sit in a wheelchair). Patients had a prolonged hospital stay (average 70.6 days) and showed minimal improvement in activities of daily living (median Barthel Index of 10). At six months, two patients regained walking ability, while five showed little improvement.Conclusion: Recovery post-MVS-associated SC-ischemia is inconsistent and often limited. Future research should focus on optimizing rehabilitation strategies for these patients suffering from this catastrophic complication.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"56-60"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication Adherence and Illness Perception in Patients with Rheumatoid Arthritis: The Mediating Effect of Self-Efficacy. 类风湿关节炎患者药物依从性与疾病感知：自我效能感的中介作用。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-101

Lei Huang, Yang Zhou, Yan Liu, Peijun Xu, Xiaohong Deng

{"title":"Medication Adherence and Illness Perception in Patients with Rheumatoid Arthritis: The Mediating Effect of Self-Efficacy.","authors":"Lei Huang, Yang Zhou, Yan Liu, Peijun Xu, Xiaohong Deng","doi":"10.22540/JMNI-25-101","DOIUrl":"10.22540/JMNI-25-101","url":null,"abstract":"Objectives: To explore the mediating effect of self-efficacy (SE) on the relationship between medication adherence (MA) and illness perception (IP) in patients with rheumatoid arthritis (RA).Methods: A convenient sampling method was used to select 238 RA patients undergoing treatment at two hospitals in Guangzhou, China. A cross-sectional survey was conducted, utilizing a general information questionnaire, a chronic disease SE scale, an IP scale, and the Medication Adherence Rating Scale (MARS-A). R software (Version 4.2.2) was used to construct a mediation model to examine the impact of SE and IP on MA among RA patients. The bootstrap method was employed to validate the mediating role of SE.Results: The average scores for IP, SE, and MA were 120.50 ± 12.32, 29.36 ± 8.49, and 21.22 ± 2.96, respectively. Pearson correlation analysis revealed that SE was positively correlated with IP (r = 0.23, p < 0.01) and MA (r = 0.195, p < 0.001). IP was also positively correlated with MA (r = 0.532, p < 0.05). The mediating effect of SE in the relationship between IP and MA was confirmed.Conclusion: SE partially mediates the relationship between IP and MA in patients with RA.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"101-108"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hip Muscle Strength and Fear of Movement are Associated with Self-Reported Function in Women with Patellofemoral Pain. 髋关节肌肉力量和运动恐惧与患有髌骨股骨痛的女性自述功能有关。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-029

Osman Coşkun, Serdar Arslan, Engin Dinç, Gökmen Yapalı

{"title":"Hip Muscle Strength and Fear of Movement are Associated with Self-Reported Function in Women with Patellofemoral Pain.","authors":"Osman Coşkun, Serdar Arslan, Engin Dinç, Gökmen Yapalı","doi":"10.22540/JMNI-25-029","DOIUrl":"10.22540/JMNI-25-029","url":null,"abstract":"Objectives: We aimed to investigate the relationship between self-reported lower extremity function, fear of movement, and quadriceps, hamstring, and hip stabilizer muscle strength in women with patellofemoral pain.Methods: Fifty-four women (age: 32.59±7.00) were included in the study. We assessed self-reported function with the Lower Extremity Functional Scale and fear of movement with the Tampa Scale for kinesiophobia. The strength of the quadriceps, hamstring, and hip stabilizer muscles was determined with a hand-held dynamometer. Relationships between variables were examined using Pearson correlation analysis and binary logistic regression analysis.Results: Self-reported function showed a moderate positive correlation with hip stabilizer muscle strength (r=0.408, p=0.002) and negative correlation with fear of movement (r=-0.500, p<0.01).Conclusion: The results of this study suggest that fear of movement and hip stabilizer muscle strength are factors associated with self-reported lower extremity function in women with patellofemoral pain.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"29-35"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maturation-Dependent Variations in Force-Velocity Profiles and Relationship with Spike Jump Performance in Female Volleyball Players. 女子排球运动员力-速度曲线的成熟相关变化及其与扣球起跳的关系。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-047

İpek Akinci, İzzet İnce

{"title":"Maturation-Dependent Variations in Force-Velocity Profiles and Relationship with Spike Jump Performance in Female Volleyball Players.","authors":"İpek Akinci, İzzet İnce","doi":"10.22540/JMNI-25-047","DOIUrl":"10.22540/JMNI-25-047","url":null,"abstract":"Objectives: This research explores the vertical force-velocity (FV) profiles of female volleyball players at different maturation stages and examines the correlation between these profiles and spike jump.Methods: Forty-two volleyball players (≥1 year training) were grouped by maturation stage-pre-PHV (n=9), mid-PHV (n=14), or post-PHV (n=19)-determined using anthropometric measurements (standing height, sitting height, leg length, and weight) and the Mirwald method to estimate maturity offset. FV profiles were assessed using Samozino's method with countermovement jumps under different loads. ANOVA with Bonferroni post-hoc tests analyzed group differences, while correlation analysis explored links between FV profiles and spike jump height (SJ).Results: Significant variances were observed among maturity groups concerning FV profile parameters, which included maximal force (F0), maximal velocity (V0), and maximal power (Pmax) (p<0.05, η2=0.19-0.69). Players at more advanced maturity stages demonstrated higher force parameters yet lower velocity values. Furthermore, only weak correlations emerged between spike jump height and parameters such as F0 and Pmax (p<0.05, r=0.31-0.39).Conclusion: Post-PHV female volleyball players exhibited greater force production, but lower velocity compared to pre- and mid-PHV players. The weak correlations between force-velocity profiles and spike jump height suggest that other factors may contribute to spike jump performance. Further research is needed to elucidate these determinants across different maturation stages.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"47-55"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Preventive Effect of the FOCUS-PDCA Management Mode on Deep Vein Thrombosis in Elderly Patients Following Orthopedic Surgery. FOCUS-PDCA 管理模式对骨科手术后老年患者深静脉血栓形成的预防效果。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-061

Fang Li, Lei Liu

{"title":"The Preventive Effect of the FOCUS-PDCA Management Mode on Deep Vein Thrombosis in Elderly Patients Following Orthopedic Surgery.","authors":"Fang Li, Lei Liu","doi":"10.22540/JMNI-25-061","DOIUrl":"10.22540/JMNI-25-061","url":null,"abstract":"Objectives: To explore the preventive effect of the FOCUS-PDCA management model on deep vein thrombosis (DVT) in elderly orthopedic patients after surgery.Methods: A total of 229 elderly patients who underwent orthopedic surgery in our hospital between January 2021 and December 2023 were divided into two groups: the control group (n=104) and the intervention group (n=125), based on their admission order. The control group received routine intervention, while the intervention group was treated with the FOCUS-PDCA model. Coagulation function, DVT risk symptoms, incidence of DVT, intervention quality, and patient satisfaction were compared between the two groups.Results: After the intervention, the PT and APTT/s levels in the intervention group were significantly better than those in the control group, while the Fibrinogen (FIB) level was significantly lower (P < 0.05). The DVT risk symptoms and incidence of DVT were also lower in the intervention group (P < 0.05). Additionally, the intervention quality and patient satisfaction were higher in the intervention group compared to the control group (P < 0.05).Conclusions: The FOCUS-PDCA management model improves coagulation function and reduces the incidence of deep vein thrombosis in elderly orthopedic patients after surgery.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"61-67"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stigmasterol, a Major Component of Cornus Officinalis, Ameliorates Osteoporosis in Diabetes Mellitus Effects by Increasing Bone Mineral Density. 山茱萸的主要成分豆甾醇通过增加骨密度改善糖尿病骨质疏松症。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-142

Hua Wang, Zexiong Mao, Haibo Xiang, Hai Huang, Xiaodong Yang, Chengliang Yang

{"title":"Stigmasterol, a Major Component of Cornus Officinalis, Ameliorates Osteoporosis in Diabetes Mellitus Effects by Increasing Bone Mineral Density.","authors":"Hua Wang, Zexiong Mao, Haibo Xiang, Hai Huang, Xiaodong Yang, Chengliang Yang","doi":"10.22540/JMNI-25-142","DOIUrl":"10.22540/JMNI-25-142","url":null,"abstract":"Objectives: This study investigated the therapeutic effects of stigmasterol (STG), derived from Cornus officinalis, on osteoporosis in rats with type 2 diabetes mellitus (T2DM).Methods: Twenty-four Male Sprague-Dawley rats (6 weeks old) were used to establish a T2DM model and were divided into four groups: normal diet (ND), high-fat diet (HFD), low-dose STG (STG-L, 100 mg/kg), and high-dose STG (STG-H, 200 mg/kg). The rats received daily gavage treatments for four weeks. Therapeutic effects were assessed by examining femoral bone structure, serum bone formation markers (P1NP, osteocalcin, and osteoprotegerin), bone resorption indices (CTX-1 and RANKL), and osteogenic protein expression (Runx2, osteopontin, and COL1A1).Results: STG significantly reduced fasting blood glucose levels and improved insulin resistance in T2DM rats. It enhanced trabecular bone microstructure, with the STG-H group demonstrating superior effects. Compared to the HFD group, STG increased bone mineral density, bone volume fraction (BV/TV), and trabecular thickness, while reducing bone surface-to-volume ratio (BS/BV) and trabecular separation. STG also elevated serum levels of P1NP, osteocalcin, and osteoprotegerin, while reducing CTX-1 and RANKL. Western blot analysis revealed increased expression of Runx2, osteopontin, and COL1A1 in femoral tissues.Conclusions: STG appears to alleviate osteoporosis in diabetes by improving bone microstructure, promoting bone formation, and reducing bone resorption, indicating its potential as a therapeutic option for managing osteoporosis.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"142-149"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanics of a Drop Landing: Osteogenic Stimulus Measures May Vary. 下落着陆的生物力学：成骨刺激措施可能会有所不同。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-001

Andrew R Wilzman, Devin T Wong, Karen L Troy

{"title":"Biomechanics of a Drop Landing: Osteogenic Stimulus Measures May Vary.","authors":"Andrew R Wilzman, Devin T Wong, Karen L Troy","doi":"10.22540/JMNI-25-001","DOIUrl":"10.22540/JMNI-25-001","url":null,"abstract":"Objectives: Impact exercises are known to increase bone mineral density (BMD) through the biological process of bone remodeling, increasing strength and resistance to fracture. The purpose of this study was to compare several measures that have been used as surrogates for bone impact as a magnitude of its potential to induce bone remodeling.Methods: Twenty healthy adults (10 male, 10 female) participated in a biomechanical investigation of how drop height and landing style (bilateral vs. unilateral) affect various estimates of bone remodeling stimuli. These stimuli surrogates include accelerations measured by Inertial Measurement Units (IMUs), ground reaction forces, joint contact forces estimated by musculoskeletal modeling, and tibia strains estimated by finite element modeling.Results: Drop height was directly related to stimulus magnitudes, but there was little benefit to drop heights greater than 0.4 m. In contrast, switching from a bilateral to a unilateral landing had a large positive effect. A post-hoc analysis revealed that a linear regression of kinematics and reaction force explained up to 79% of the variance in computationally expensive bone remodeling stimulus measures.Conclusions: subject-specific bone strain analysis may not be necessary to understand the magnitude of a bone remodeling stimulus of an exercise.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"1-17"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tendon-Derived Stem Cell Sheet Promotes Early-Stage Tendon-Bone Healing. 肌腱来源干细胞片促进早期肌腱骨愈合。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-133

Junyan Liu, Guangchun Dai, Longfei Xiao, Yunfeng Rui

{"title":"Tendon-Derived Stem Cell Sheet Promotes Early-Stage Tendon-Bone Healing.","authors":"Junyan Liu, Guangchun Dai, Longfei Xiao, Yunfeng Rui","doi":"10.22540/JMNI-25-133","DOIUrl":"10.22540/JMNI-25-133","url":null,"abstract":"Objectives: To investigate the role of a tendon-derived stem cell (TDSC) sheet in tendon-bone healing within an extra-articular bone tunnel rat model.Methods: Sprague-Dawley rats were randomly assigned to experimental and control groups. The superficial flexor tendon, with or without a TDSC sheet, was transplanted into a 1.0-mm diameter bone tunnel in the proximal tibia. The impact of the TDSC sheet on tendon-bone healing was assessed through radiological analysis, histological staining, and biomechanical testing.Results: The TDSC sheet significantly enhanced tendon-bone healing, as evidenced by higher tunnel bone mineral density and bone volume/total volume at 4 weeks post-operation. Hematoxylin-eosin staining revealed that the TDSC sheet promoted the alignment of perpendicular collagen fibers connecting the tendon to the bone, along with Sharpey's fibers and new bone formation at the tendon-bone junction at both 4 and 8 weeks. Additionally, Masson's staining demonstrated that the tendon-bone interface was filled with abundant collagen fibers, with a significantly higher proportion of collagen fiber area in the TDSC sheet group compared to the control group at both 4 and 8 weeks.Conclusion: The TDSC sheet may enhance tendon-bone healing in the early stages, providing a potential therapeutic approach to accelerate tendon-bone remodeling.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"133-141"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0