Journal of musculoskeletal & neuronal interactions最新文献_第4页

Acute Effects of Static Stretching and Mulligan Bent Leg Raise on Hamstring Flexibility and Jumping Performance in Asymptomatic Young Adults: A Single-Session Study. 静态拉伸和Mulligan屈腿抬高对无症状年轻人腿筋柔韧性和跳跃表现的急性影响：一项单期研究。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-06-01

Tahir Keskin, Mesut Ergan, Zeliha Başkurt, Ferdi Başkurt

{"title":"Acute Effects of Static Stretching and Mulligan Bent Leg Raise on Hamstring Flexibility and Jumping Performance in Asymptomatic Young Adults: A Single-Session Study.","authors":"Tahir Keskin, Mesut Ergan, Zeliha Başkurt, Ferdi Başkurt","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: This study compared the acute effects of static stretching (SS) and the Mulligan bent leg raise (BLR) technique on hamstring flexibility and jumping performance in asymptomatic young adults.Methods: Forty-two participants with bilateral hamstring tightness were randomly assigned to the SS or BLR group (n = 21 each). Active knee extension (AKE), vertical jump (VJ), and single-leg hop (SLH) performance were assessed before and immediately after a single intervention session.Results: A significant main effect of time was found for all outcomes (p < 0.05). Significant time × method interactions were observed for AKE and SLH, but not for VJ. The BLR group showed greater improvements in hamstring flexibility (AKE: +6.38°) compared with the SS group (+2.10°). SLH performance improved more in the BLR group, whereas VJ improvements were similar between groups. After adjusting for baseline AKE differences, post-intervention AKE remained significantly higher in the BLR group.Conclusion: Both SS and BLR produced beneficial acute effects on hamstring flexibility and jumping performance. BLR demonstrated larger acute improvements in hamstring flexibility and single-leg hop performance in this sample; however, these findings should be interpreted cautiously and may not be directly generalizable to athletic populations.Clinicaltrials: gov ID: NCT07138950.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 2","pages":"234-241"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical Load-Capacity Models for Bone in Youth - Analysis of Risk Signatures. 青少年骨骼的机械负荷-能力模型-风险特征分析。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Marília Marques, Paula Bruno, Filomena Vieira, Fátima Baptista

{"title":"Mechanical Load-Capacity Models for Bone in Youth - Analysis of Risk Signatures.","authors":"Marília Marques, Paula Bruno, Filomena Vieira, Fátima Baptista","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: to explore associations between mechanical load, expressed by structural (appendicular lean soft tissue index, ALSTI; ALST/trunk fat mass, TrFM); and functional lean mass (handgrip strength, HGS; HGS/body mass) with the mechanical capacity of bone, represented by whole-body bone mineral density less head (WBLH BMD) and arms/legs BMD imbalance.Methods: We analysed cross-sectional NHANES data from 5,424 adolescents (10-19 years, both sexes) collected between 2011 and 2020. ALST, TrFM and BMD were determined using whole-body dual-energy X-ray absorptiometry, and HGS was assessed with a dynamometer. All variables were standardised by sex and age group (Z-scores), with Z ≤ -1 indicating low or at-risk values.Results: The odds of low WBLH BMD were higher in participants with low ALSTI (girls: OR= 3.9; boys: OR=4.5, p < 0.001) or low HGS (girls: OR=3.1; boys: OR=4.5, p < 0.001). Boys with low HGS/body mass had 1.8 times higher odds of low arms/legs BMD (p = 0.012), while girls with low HGS/body mass had 4.0 times higher odds (p < 0.001).Conclusions: Both structural and functional lean mass deficits are associated with reduced WBLH BMD and arms/legs BMD imbalance in adolescents. These findings reinforce the importance of lean soft tissue in bone health monitoring.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"76-86"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Kinetic Control Retraining on Neck Proprioception and Function in Cervical Radiculopathy: A Randomized Controlled Trial. 动力控制再训练对颈神经根病患者颈部本体感觉和功能的影响：一项随机对照试验。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Ebtesam Wafik Shehab, Nahed Ahmed Salem, Sandra Ahmed, Abdelaziz Abdelaziz Elsherif, Nagwa Ibrahim Rehab

{"title":"Effect of Kinetic Control Retraining on Neck Proprioception and Function in Cervical Radiculopathy: A Randomized Controlled Trial.","authors":"Ebtesam Wafik Shehab, Nahed Ahmed Salem, Sandra Ahmed, Abdelaziz Abdelaziz Elsherif, Nagwa Ibrahim Rehab","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Cervical radiculopathy is a prevalent neuromusculoskeletal disorder which negatively impacts quality of life. Kinetic control concept indicates that the main goals of rehabilitation are to improve motor control and stabilize the cervical spine. The aim of this study was to assess the impact of kinetic control retraining on neck proprioception and function in individuals with cervical radiculopathy.Methods: A total of forty-four participants, aged 40 to 55, diagnosed with chronic unilateral cervical spondylotic radiculopathy, were randomly divided into two equal groups. The study group received kinetic control retraining along with the conventional physical therapy protocol. The control group underwent a conventional physical therapy protocol, comprising three sessions weekly for eight successive weeks. Cervical joint position error was assessed through cervical range of motion, pain levels were measured by the Visual Analogue Scale, neck-related disability was evaluated using Arabic Neck Disability Index scores, and deep neck flexor performance was tested with a pressure-biofeedback device.Results: After eight weeks of intervention, statistically significant differences between groups were observed across all outcome measures, favoring the study group (P < 0.05).Conclusion: Kinetic Control retraining has a useful effect on managing chronic cervical radiculopathy by reducing pain and enhancing proprioception and functional abilities.Clinicaltrials: gov ID: NCT06803134.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"97-107"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight-Week Shoulder Flexibility Program Improves Serve Accuracy and Select ROM in Youth Volleyball: A Randomized Controlled Trial. 八周肩部柔韧性训练提高青少年排球发球准确性和选择ROM：一项随机对照试验。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Aziz Enes Sahin, Selim Asan, Esedullah Akaras

{"title":"Eight-Week Shoulder Flexibility Program Improves Serve Accuracy and Select ROM in Youth Volleyball: A Randomized Controlled Trial.","authors":"Aziz Enes Sahin, Selim Asan, Esedullah Akaras","doi":"","DOIUrl":"","url":null,"abstract":"Objective: This study investigated the effects of an eight-week shoulder flexibility exercise program on shoulder range of motion (ROM) and serve accuracy in youth volleyball players.Methods: Thirty-two adolescent players (12-13 years) were randomly assigned to an experimental group (EG, n=16) and a control group (CG, n=16). The EG performed structured flexibility exercises twice weekly in addition to regular training, while the CG continued routine volleyball practice only. Shoulder ROM was assessed with a goniometer, and serve accuracy was evaluated using a standardized scoring protocol (maximum 48 points).Results: Significant improvements were observed over time in both groups for most ROM variables (p < 0.001). However, significant group differences emerged for shoulder external rotation (F1,29=5.42, p=0.027, ηp2=0.153) and serve accuracy (Time×Group: F=6.73, p=0.015, ηp2=0.183). The adjusted ANCOVA confirmed a significant group effect for external rotation (F1,29=4.28, p=0.048, ηp2=0.128). The experimental group improved serve accuracy by +17.2 points (95% CI: 15.6-18.8) versus +11.6 points (95% CI: 9.4-13.8) in the control group.Conclusion: The eight-week flexibility program significantly enhanced serve accuracy and select shoulder ROM parameters in youth volleyball players. Incorporating structured flexibility exercises into training routines may improve technical performance and support shoulder function development during early adolescence.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"55-64"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary to: Neuropathic Pain Component in Patients with Ankylosing Spondylitis and the Relationship of Neuropathic Pain and Disease Activity Parameters: A Cross-Sectional Study. 评论：强直性脊柱炎患者的神经性疼痛成分以及神经性疼痛与疾病活动参数的关系：一项横断面研究。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Belgin Erhan, Ekim Can Öztürk, Menekşe Başal

引用次数: 0

Investigation of the Relationship Between Core Stability and Reaction Time in Taekwondo Athletes. 跆拳道运动员核心稳定性与反应时间关系的研究。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

İnci Kesilmiş, Ayşe Hazal Boyanmiş, Manolya Akin, Feride Berfin Yelbaşi

{"title":"Investigation of the Relationship Between Core Stability and Reaction Time in Taekwondo Athletes.","authors":"İnci Kesilmiş, Ayşe Hazal Boyanmiş, Manolya Akin, Feride Berfin Yelbaşi","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: To examine the relationship between technical reaction time and core stabilization in taekwondo athletes.Methods: Cross-sectional correlational study of healthy male and female taekwondo athletes (n = 41; mean age 12.76 ± 1.07 years). Reaction performance was assessed using FITLIGHT Trainer sensors mounted on a taekwondo striking stand. Core stabilization was assessed using the Stabilizer Pressure Biofeedback Unit (PBU), a device employed to evaluate core muscle stabilization and deep abdominal muscle function. Spearman correlations (non-normal data) and Mann-Whitney U tests (sex comparisons) were applied.Results: Shorter reaction times were associated with a higher number of successful strikes (p < 0.05). Higher PBU task performance (time held) of the transversus abdominis muscle and multifidus muscle correlated with higher strike success rates. In unadjusted comparisons, male athletes achieved more successful strikes on both right and left sides and completed tasks with fewer errors; however, after adjusting for age, height, and weight, sex was not a significant predictor of outcomes. Transversus abdominis PBU task performance (time held) was significantly higher in males in unadjusted analyses, indicating superior core stabilization compared to females.Conclusion: These findings suggest that deep core muscles are important not only for postural stability but also for dynamic motor performance.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"87-96"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-Vivo Force-Length Relationship of the Medial Gastrocnemius Muscle in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders. 超活动ehers - danlos综合征和超活动谱系障碍中腓肠肌内侧肌的体内力-长度关系。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Donald W Golden, Jason P Oliemans, Aera J M Ladell, Kalindra D Walls, Eric C Bennett, Spencer J Skaper, Michael J Asmussen, Ranita H K Manocha, Jared R Fletcher

{"title":"In-Vivo Force-Length Relationship of the Medial Gastrocnemius Muscle in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders.","authors":"Donald W Golden, Jason P Oliemans, Aera J M Ladell, Kalindra D Walls, Eric C Bennett, Spencer J Skaper, Michael J Asmussen, Ranita H K Manocha, Jared R Fletcher","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: To determine the force-length relationship, muscle thickness (MT), pennation angle (PA) and echo-intensity (EI) of the medial gastrocnemius (MG) in HSD/hEDS compared to healthy controls.Methods: The maximal MG force-length relationship was determined throughout ankle passive ROM in 11 individuals with HSD/hEDS and 11 healthy age- and sex-matched controls. MG fascicle length (FL), MT, PA and EI were measured using ultrasonography. MG force was calculated from plantarflexion moments and MG FL. Sarcomere lengths (SL) were estimated from changes in FL and assuming an optimal SL of 2.64 μm at optimal fascicle length.Results: HSD/hEDS were 36% weaker across the ankle ROM (p = 0.047). Optimal FL was significantly shorter in HSD/hEDS (34.8±8.1 mm) compared to controls (43.6±6.9 mm; p = 0.013). A shallower descending limb of the force-length relationship was seen in HSD/hEDS (p <0.001). MT, PA, and EI were similar between groups (p > 0.05).Conclusion: HSD/hEDS were weaker at all measured fascicle lengths, despite similar muscle architecture (MT, PA) and quality (EI) suggesting that reduced neuromuscular activation may contribute to muscle weakness in this population. Rehabilitation interventions should consider addressing joint-angle specific strength deficits in HSD/hEDS.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METTL3-mediated GLUD1 m6A Modification Promotes Hydrogen Peroxide-induced Mitochondrial Dysfunction in Human Nucleus Pulposus Cells Via the Glutamate/α-KG Metabolic Axis. mettl3介导的GLUD1 m6A修饰通过谷氨酸/α-KG代谢轴促进过氧化氢诱导的人髓核细胞线粒体功能障碍

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Ming Bai, Yimin Wu, Yang Zhang, Haibin Zhang, Peng Wang, Shuwen Li

{"title":"METTL3-mediated GLUD1 m6A Modification Promotes Hydrogen Peroxide-induced Mitochondrial Dysfunction in Human Nucleus Pulposus Cells Via the Glutamate/α-KG Metabolic Axis.","authors":"Ming Bai, Yimin Wu, Yang Zhang, Haibin Zhang, Peng Wang, Shuwen Li","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Human nucleus pulposus cells (HNPCs), the primary cellular constituents of the intervertebral disc, are central to the pathogenesis of intervertebral disc degeneration (IVDD). Oxidative stress-induced mitochondrial dysfunction leads to intracellular metabolic imbalance and has been implicated in IVDD. This study investigated the role and molecular mechanism of glutamate dehydrogenase 1 (GLUD1) in hydrogen peroxide (H2O2)-challenged HNPCs relevant to IVDD.Methods: HNPCs were exposed to H2O2 to establish an oxidative stress model. Cell viability was assessed using the CCK-8 assay. Mitochondrial function was evaluated by measuring the oxygen consumption rate (OCR) and mitochondrial membrane potential. GLUD1 expression was quantified by qRT-PCR and Western blotting. The regulatory relationship between METTL3 and GLUD1 was examined by MeRIP-qPCR and a luciferase reporter assay.Results: H2O2 treatment decreased OCR and mitochondrial membrane potential in HNPCs and reduced alpha-ketoglutarate (α-KG) levels and GLUD1 expression. GLUD1 knockdown exacerbated H2O2-induced mitochondrial dysfunction, whereas GLUD1 overexpression alleviated it. METTL3 regulated GLUD1 mRNA stability by inducing GLUD1 m6A modification via YTHDF2, thereby modulating H2O2-induced mitochondrial dysfunction.Conclusion: GLUD1 protects HNPCs from H2O2-induced mitochondrial dysfunction through the glutamate/α-KG metabolic axis.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"147-161"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in Ankle Eversion-to-Inversion Muscle Strength and Postural Control in Individuals with Chronic Lateral Ankle Instability. 慢性踝关节外侧不稳定患者踝关节内翻肌力和姿势控制的改变。

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Wei-Chuang Cai, Xiao-Bing Cai, Yue-Zhen Liang, Wen-Shuang Cao, Zhi-Ning Zhang, Wen-Zhen Shao, Yong Zhang

{"title":"Alterations in Ankle Eversion-to-Inversion Muscle Strength and Postural Control in Individuals with Chronic Lateral Ankle Instability.","authors":"Wei-Chuang Cai, Xiao-Bing Cai, Yue-Zhen Liang, Wen-Shuang Cao, Zhi-Ning Zhang, Wen-Zhen Shao, Yong Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Objective: This study examined alterations in ankle eversion/inversion strength and postural control in chronic lateral ankle instability (CLAI).Methods: Twenty-three CLAI patients and 14 matched controls underwent isokinetic strength testing at 30°/s, 60°/s, and 90°/s (peak torque/body weight: PT/BW). Postural control was assessed via center-of-pressure (COP) trajectory length and peripheral area during eyes-open and eyes-closed single-leg stance.Results: The CLAI group demonstrated significantly lower eversion PT/BW across all angular velocities versus controls (p<0.05). Inversion PT/BW was not significantly different for the group effect (p>0.05). The eversion-to-inversion strength ratio was consistently lower in CLAI (p<0.05). No between-group differences in COP metrics occurred during eyes-open stance (p>0.05). However, with eyes closed, the CLAI group exhibited significantly longer COP trajectory [107.52 (94.90,118.70) cm vs. 93.75 (83.09,95.25) cm] and larger peripheral area [8.34 (5.73,12.90) cm2 vs. 5.92 (5.05,6.88) cm2] (p<0.05).Conclusions: CLAI is characterized by eversion muscle weakness and an impaired eversion-to-inversion strength ratio. Postural control deficits manifest primarily under visual deprivation, suggesting proprioceptive impairment, though visual input enables partial compensation during eyes-open conditions.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"65-75"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the STK39/ARID2 Axis to Inhibit NF-κB Signaling: A Novel Pathway for Mesenchymal Stem Cell Osteogenic Differentiation in Osteoporosis Management. 靶向STK39/ARID2轴抑制NF-κB信号：骨质疏松症治疗中间充质干细胞成骨分化的新途径

IF 1.9 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2026-03-01

Yang Wang, Dong Wei, Zhineng Chen, Liang Zhong

{"title":"Targeting the STK39/ARID2 Axis to Inhibit NF-κB Signaling: A Novel Pathway for Mesenchymal Stem Cell Osteogenic Differentiation in Osteoporosis Management.","authors":"Yang Wang, Dong Wei, Zhineng Chen, Liang Zhong","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Osteoporosis (OP) is a prevalent bone disease characterized by reduced bone mass and increased fracture risk, in part due to impaired osteogenic differentiation of bone marrow-derived mesenchymal stromal cells (BMSCs). Loss of AT-rich interactive domain-containing protein 2 (ARID2) attenuates BMSC osteogenesis, but the underlying mechanism remains to be elucidated.Methods: Human BMSCs were induced to undergo osteogenic or adipogenic differentiation. Lentiviral transduction was used to silence ARID2 and/or overexpress serine/threonine kinase 39 (STK39). Effects on BMSC fate were assessed by quantitative reverse-transcription PCR (qRT-PCR), MTT assay, alkaline phosphatase (ALP) staining, Alizarin Red S (ARS) staining, Oil Red O staining, and western blotting.Results: ARID2 expression increased over time during osteogenic induction. ARID2 silencing reduced BMSC proliferation and osteogenic differentiation while favoring adipogenesis. Conversely, STK39 overexpression enhanced proliferation and osteogenic differentiation and attenuated nuclear factor κB (NF-κB) signaling during osteogenic induction; these effects were reversed by ARID2 silencing.Conclusion: The STK39-ARID2 axis promotes osteogenic differentiation and suppresses adipogenic differentiation of BMSCs, at least in part via inhibition of NF-κB signaling. These findings highlight a potential molecular target for therapeutic strategies in OP.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"124-133"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0