Journal of musculoskeletal & neuronal interactions最新文献

筛选
英文 中文
HOXA7 Impairs Osteogenic Differentiation via p38/JNK Signaling: Implications for Osteoporosis. HOXA7通过p38/JNK信号抑制成骨分化:对骨质疏松症的影响
IF 1.9 4区 医学
Yijun Wang, Jingjing Zhang, Bo Wang, Ziwei Wang, Peirui Miao, Yanke Hao
{"title":"HOXA7 Impairs Osteogenic Differentiation via p38/JNK Signaling: Implications for Osteoporosis.","authors":"Yijun Wang, Jingjing Zhang, Bo Wang, Ziwei Wang, Peirui Miao, Yanke Hao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate the role and mechanism of HOXA7 in osteoporosis (OP), with the goal of informing future research directions in OP.</p><p><strong>Methods: </strong>We assessed HOXA7 gene and protein expression; the effect of HOXA7 on osteogenic differentiation in human bone marrow-derived mesenchymal stem cells (hBMSCs); and proliferation, apoptosis, and autophagy in MC3T3-E1 cells. We also evaluated p38 MAPK/JNK pathway-associated proteins in hBMSCs and MC3T3-E1 cells. Cells were transfected with si-HOXA7 and cultured with or without the JNK inhibitor SP600125 or the p38 inhibitor SB203580, after which cell viability, apoptosis, and autophagy were re-assessed.</p><p><strong>Results: </strong>HOXA7 overexpression inhibited osteogenic differentiation of hBMSCs, reduced OPG, OPN, and RUNX2 expression in hBMSCs, and decreased proliferation while promoting apoptosis in MC3T3-E1 cells. In vitro, HOXA7 modulated autophagy markers in MC3T3-E1 cells. Phosphorylated JNK and p38 (p-JNK, p-p38) were increased in hBMSCs following osteogenic induction, whereas HOXA7 upregulation significantly suppressed p-JNK and p-p38 in MC3T3-E1 cells. SP600125 and SB203580 attenuated the effects of HOXA7 silencing on proliferation, apoptosis, and autophagy in MC3T3-E1 cells.</p><p><strong>Conclusion: </strong>HOXA7 reduces osteogenesis and osteoblast proliferation and promotes osteoblast apoptosis via the p38 MAPK/JNK pathway, suggesting potential therapeutic avenues against OP.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"134-146"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Muscle Function in Children with Achondroplasia Under Vosoritide Treatment: A Retrospective Single-Centre Observational Study. Vosoritide治疗下软骨发育不全儿童肌肉功能的发展:一项回顾性单中心观察研究。
IF 1.9 4区 医学
Susanna Reincke, Stefanie Stasek, Shino Junghänel-Welzing, Oliver Semler, Mirko Rehberg, Ibrahim Duran, Heike Hoyer-Kuhn
{"title":"Development of Muscle Function in Children with Achondroplasia Under Vosoritide Treatment: A Retrospective Single-Centre Observational Study.","authors":"Susanna Reincke, Stefanie Stasek, Shino Junghänel-Welzing, Oliver Semler, Mirko Rehberg, Ibrahim Duran, Heike Hoyer-Kuhn","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Vosoritide, a C-type natriuretic peptide analog, is the first approved pharmacological treatment for achondroplasia that targets the overactive FGFR3 pathway and promotes longitudinal bone growth. As increased body height may improve biomechanical leverage and influence muscle function, this retrospective, monocentric, observational study aimed to evaluate changes in muscle performance parameters during long-term vosoritide treatment.</p><p><strong>Methods: </strong>Nineteen (19) children with achondroplasia treated with vosoritide for at least 12 months were included. Muscle function was assessed via two-legged jump tests on a ground reaction force plate at baseline, month 12, 24 and 36. Jumping parameters, 6-minute walking distances and auxological measurements were converted to z-scores. Longitudinal changes were detected using a linear mixed-effects model.</p><p><strong>Results: </strong>Vosoritide treatment resulted in significant gains in height z-scores over 36 months (p < 0.001). Raw values of jumping parameters increased numerically over time for all parameters except relative force; however, no significant changes were observed in z-scores. Similarly, no significant changes were detected in 6-minute walking distances.</p><p><strong>Conclusions: </strong>While vosoritide produced significant height gains, no significant changes in muscle function z-scores were observed in this cohort. These findings are exploratory and suggest that muscle function may develop in parallel with that of unaffected children.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"39-54"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hip Girdle Muscle Activation by Whole-Body Vibration to Achieve the Impact of Walking and Running: A Prospective Pilot Study in Healthy Children. 通过全身振动激活臀带肌肉来实现步行和跑步的影响:一项健康儿童的前瞻性先导研究。
IF 1.9 4区 医学
Won-Jae Jo, Eunseo Choi, Jee Hyun Suh, Jiwoon Lim, Ju Seok Ryu
{"title":"Hip Girdle Muscle Activation by Whole-Body Vibration to Achieve the Impact of Walking and Running: A Prospective Pilot Study in Healthy Children.","authors":"Won-Jae Jo, Eunseo Choi, Jee Hyun Suh, Jiwoon Lim, Ju Seok Ryu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This prospective pilot study in healthy children aimed to evaluate the effect of whole-body vibration therapy (WBVT) on hip girdle muscle activation and identify the optimal amplitude and frequency settings that replicate the effects of walking or running without causing discomfort.</p><p><strong>Methods: </strong>A prospective pilot study involving 20 healthy children was conducted to evaluate muscle activation during WBVT at amplitudes of 1, 2, and 3 mm and frequencies of 5-20 Hz. Surface electromyography of the gluteus medius, tensor fascia lata, iliopsoas, and rectus femoris was recorded during walking, running, and WBVT trials, and steady-state 10-s epochs were extracted for analysis.</p><p><strong>Results: </strong>Although dose-response analyses showed no statistically significant increases beyond 10 Hz within WBVT conditions, the reported thresholds specify the vibration settings at which WBVT-induced activation exceeded the RMS values observed during walking or running, rather than indicating significant within-WBVT frequency differences. When \"optimal setting\" was defined as the highest activation within tolerable ranges, the 3 mm/ 10 Hz setting met these criteria.</p><p><strong>Conclusions: </strong>WBVT produced short-term increases in hip-girdle muscle activation under tolerable conditions. While not indicative of therapeutic benefit, these data provide hypothesis-generating insights for future clinical studies involving children with movement limitations.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"22-38"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reliability and Correlations Among Handgrip Strength Measurements and Muscle Power in Older Women. 老年妇女握力测量与肌肉力量的信度与相关性。
IF 1.9 4区 医学
Alexandra L Khartabil, Ty B Palmer
{"title":"Reliability and Correlations Among Handgrip Strength Measurements and Muscle Power in Older Women.","authors":"Alexandra L Khartabil, Ty B Palmer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>The reliability of handgrip strength measurements and their relationship with muscle power in older adults is not well understood. This study aimed to determine the reliability and correlations between handgrip strength measurements and muscle power in older women.</p><p><strong>Methods: </strong>Twenty older healthy women (67.8±5.8 years) participated in two separate testing sessions. During each session, handgrip contractions were performed to evaluate strength, specifically measuring peak force and rate of force development (RFD) across various time intervals. Muscle power was assessed by measuring sit-to-stand peak power and seated medicine ball throw distance.</p><p><strong>Results: </strong>Handgrip strength measurements, sit-to-stand peak power, and seated medicine ball throw distance demonstrated good test-retest reliability. The intraclass correlation coefficients were between 0.930 and 0.978. The coefficients of variation were between 2.7 and 8.0%. There were significant correlations between handgrip strength measurements and both sit-to-stand peak power (r = 0.485-0.533, P = 0.015-0.030) and seated medicine ball throw distance (r = 0.457-0.634, P = 0.003-0.043).</p><p><strong>Conclusions: </strong>Our study showed good reliability for handgrip strength measurements, sit-to-stand peak power, and seated medicine ball throw distance in older women. The significant correlations we observed suggest that handgrip peak force and RFD may be important variables associated with one's muscle power.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"13-21"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smartphone-Assessed Single-Leg Deadlift Stability is Associated with Sprint Velocity in Youth Soccer Players: A Cross-Sectional Study. 智能手机评估的单腿硬举稳定性与青少年足球运动员的冲刺速度有关:一项横断面研究。
IF 1.9 4区 医学
Pedro J Marín, Raúl Zarzuela-Martín, Daniel Rabadan-García, Sergio Sánchez-García, Álvaro López-Samanes
{"title":"Smartphone-Assessed Single-Leg Deadlift Stability is Associated with Sprint Velocity in Youth Soccer Players: A Cross-Sectional Study.","authors":"Pedro J Marín, Raúl Zarzuela-Martín, Daniel Rabadan-García, Sergio Sánchez-García, Álvaro López-Samanes","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the relationship between core stability and neuromuscular performance (i.e., sprint velocity and change-of-direction speed) among adolescent male football players.</p><p><strong>Methods: </strong>In this cross-sectional study, sixteen high-level male football players were divided into higher and lower core stability groups based on their performance in a partial range single-leg deadlift (SLD) test, assessed using a smartphone application (OCTOcore© app). Neuromuscular performance was assessed with a 30-m maximal sprint test (with 5-m split intervals) and a V-cut test, and these outcomes were correlated with SLD test results.</p><p><strong>Results: </strong>Statistically significant differences were observed between higher and lower core performance groups in the SLD test (p = 0.001) and between SLD non-dominant and 30-m maximal sprint test (p = 0.001-0.005), while no differences were founded between SLD performance and V-cut test (p>0.05). A large correlation was found between non-dominant SLD and 10-m sprint performance (r = 0.765, p = 0.001), while moderate correlations were observed for the 15-, 20-, 25-, and 30-m sprints (r = 0.508-0.562, p = 0.023-0.044). No significant correlations between SLD performance and the V-cut test (p>0.05).</p><p><strong>Conclusion: </strong>Core stability appears to be positively associated with sprint performance (0-30 m) but not with change-of-direction speed, suggesting that it plays a greater role in linear acceleration than in multidirectional tasks.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"108-114"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary to: The Preventive Effect of the FOCUS-PDCA Management Mode on Deep Vein Thrombosis in Elderly Patients Following Orthopedic Surgery. 点评:FOCUS-PDCA管理模式对老年骨科术后患者深静脉血栓形成的预防效果。
IF 1.9 4区 医学
Jiayi Chen
{"title":"Commentary to: The Preventive Effect of the FOCUS-PDCA Management Mode on Deep Vein Thrombosis in Elderly Patients Following Orthopedic Surgery.","authors":"Jiayi Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"164"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features in Children with Persistent Toe Walking Who Carry Heterozygous PYGM Variants: A Cross-Sectional Study. 携带杂合子PYGM变异的持续性脚趾行走儿童的临床特征:一项横断面研究。
IF 1.9 4区 医学
David Pomarino, Bastian Fregien, Kevin M Rostásy
{"title":"Clinical Features in Children with Persistent Toe Walking Who Carry Heterozygous PYGM Variants: A Cross-Sectional Study.","authors":"David Pomarino, Bastian Fregien, Kevin M Rostásy","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Persistent toe walking (TW) in children is often idiopathic but may conceal subtle neuromuscular or metabolic causes. This cross-sectional, retrospective study investigated clinical and genetic characteristics of children carrying PYGM variants to explore potential subclinical phenotypes among heterozygous carriers.</p><p><strong>Methods: </strong>Seventy-two (72) children meeting criteria for idiopathic TW were evaluated using a standardized clinical protocol and a validated 49-gene next-generation sequencing neuromuscular panel. Variants were classified as pathogenic, likely pathogenic, or of uncertain significance according to ACMG/AMP guidelines. Analyses were descriptive.</p><p><strong>Results: </strong>Among 1,300 screened patients, 72 were identified as PYGM variant carriers. Toe walking was bilateral in all cases, with severe dorsiflexion restriction (≤ 5°) in 80.5%. Pes cavus was observed in 93% of patients, and muscle symptoms-pain, fatigue, or cramps-occurred in approximately one-third. VUS carriers displayed comparable, slightly milder muscle symptom frequencies than P/LP carriers. 12.5% could perform heel walking. Speech difficulties were reported in 56.9% of cases.</p><p><strong>Conclusions: </strong>While causality cannot be inferred, these findings suggest that heterozygous PYGM variants may contribute to subtle neuromuscular phenotypes. Genetic testing can be considered in persistent TW when clinical findings raise suspicion for an underlying neuromuscular/metabolic condition.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"26 1","pages":"115-123"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone Disease in Primary Hyperparathyroidism. 原发性甲状旁腺功能亢进的骨病。
IF 1.6 4区 医学
Efthymia Karlafti, Irene Lambrinoudaki, Ioannis Vlamis, Efstathios Chronopoulos, Eva Kassi, Ismene Dontas, Symeon Tournis
{"title":"Bone Disease in Primary Hyperparathyroidism.","authors":"Efthymia Karlafti, Irene Lambrinoudaki, Ioannis Vlamis, Efstathios Chronopoulos, Eva Kassi, Ismene Dontas, Symeon Tournis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Primary Hyperparathyroidism (PHPT) is a common endocrine disorder characterized by autonomous secretion of parathyroid hormone (PTH) leading to hypercalcemia. Whereas bone mineral density (BMD) is generally preserved at skeletal sites rich in trabecular bone, such as the lumbar spine (LS), studies, using peripheral quantitative computed tomography (pQCΤ) and high-resolution peripheral quantitative computed tomography (HR-pQCΤ), have revealed disruption of both cortical and trabecular bone microarchitecture, even in the contemporary 'asymptomatic' form of the disease, highlighting the catabolic effect of PHPT on bone. Moreover, epidemiological studies reported increased fracture risk in patients with PHPT, even in those with BMD T-score within normal or osteopenic range, suggesting that there is a discrepancy between BMD and fracture risk in patients with PHPT and that new diagnostic methods are needed for assessing bone fragility in this population. Surgery is the only definitive treatment for PHPT. Non-surgical treatment is recommended in patients who do not meet the criteria for surgical management, in patients who deny surgical treatment or are high-risk surgical patients. The most frequently used agents are bisphosphonates, denosumab, cinacalcet and vitamin D supplementation.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 4","pages":"486-500"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12684280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hindlimb Suspension and Subsequent Weight-Loading on Femoral Morphology, Knee Joint Alignment, and Patellar Tracking in Growing Rats. 后肢悬吊和随后的负重对生长大鼠股骨形态、膝关节对齐和髌骨追踪的影响。
IF 1.6 4区 医学
Marina Kanehara, Airi Ikeda, Akinori Kaneguchi, Junya Ozawa
{"title":"Hindlimb Suspension and Subsequent Weight-Loading on Femoral Morphology, Knee Joint Alignment, and Patellar Tracking in Growing Rats.","authors":"Marina Kanehara, Airi Ikeda, Akinori Kaneguchi, Junya Ozawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Reduced weight-loading on the lower extremities during growth induces abnormal bone morphology and malalignment, but the effects of reloading on these abnormalities remain unknown. We aimed to determine the specific timeframes in which hindlimb suspension (HS) during growth induces abnormal femoral morphologies and knee malalignments present at skeletal maturity in rats.</p><p><strong>Methods: </strong>Four-week-old female rats were subjected to HS for one, two, or four weeks using the tail suspension method, followed by reloading. Age-matched rats were used as controls. At 12 weeks of age, femoral morphology and knee joint alignment were assessed using X-ray computed tomography.</p><p><strong>Results: </strong>Femoral anteversion angle, medial/lateral condylar height ratio (MC/LC), and patellar tilt angle were significantly larger, while trochlear angle, lateral condylar height (LC), and lateral trochlear inclination (LTI) were smaller in the groups that underwent HS for two or four weeks prior to reloading, compared with the control group. There were significant correlations between LTI and LC (r = 0.57), MC/LC (r = -0.42), and patellar tilt angle (r = -0.49). In the 4-week HS group, lateral patellar dislocation was observed in 3 of 8 animals.</p><p><strong>Conclusion: </strong>Insufficient weight-loading more than two weeks during growth may induce knee joint instability even after reloading.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 4","pages":"463-475"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12684259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Local Pelvic Bone Volumetric Density and Cortical Thickness Using Multi-Energy Bi-Planar Radiography. 应用多能双平面x线摄影评估局部骨盆骨体积密度和皮质厚度。
IF 1.6 4区 医学
Ningxin Qiao, Isabelle Villemure, Carolina Solorzano Barrera, Carl-Eric Aubin
{"title":"Assessment of Local Pelvic Bone Volumetric Density and Cortical Thickness Using Multi-Energy Bi-Planar Radiography.","authors":"Ningxin Qiao, Isabelle Villemure, Carolina Solorzano Barrera, Carl-Eric Aubin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study presents a method to determine the volumetric density of pelvic bone and cortical bone thickness along critical regions of the S2 alar-iliac (S2AI) screw trajectory using bi-planar multi-energy X-ray (BMEX).</p><p><strong>Methods: </strong>Simulated BMEXs were generated from CT data from eight patients, with coordinate matching linking pixels to voxel density values. This dataset included pixel attenuation values, coordinates as independent variables, and voxel attenuation values (Hounsfield Units, HU) as the dependent variable for training a random forest regressor model.</p><p><strong>Results: </strong>The trained model revealed adequate trabecular bone density prediction (root mean square error: 32.8 mg/cm<sup>3</sup>) and cortical thickness accuracy (error ≤1.2 mm). Trabecular bone showed a minor tendency for density overestimation with a maximum difference of 83 HU, while cortical bone exhibited an underestimation of up to 118 HU.</p><p><strong>Conclusions: </strong>The improved prediction of bone density and the capability to estimate cortical bone thickness signify a significant advancement towards a comprehensive modality for predicting bone quality in implant placement planning.</p>","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 4","pages":"371-376"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12684272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书