Journal of musculoskeletal & neuronal interactions最新文献_第5页

Characterization and Biocompatibility Assessment of 3D-Printed HA/PCL Porous Bionic Bone Scaffold: in Vitro and in Vivo Evaluation. 3d打印HA/PCL多孔仿生骨支架的表征和生物相容性评价：体外和体内评价。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI: 10.22540/JMNI-25-119

Shi Shen, Benchao Shu, Yulin Xu, Heng Zhao, Yang Li, Yujie Li, Chuanchuan Zhuo, Naiqiang Zhuo

{"title":"Characterization and Biocompatibility Assessment of 3D-Printed HA/PCL Porous Bionic Bone Scaffold: in Vitro and in Vivo Evaluation.","authors":"Shi Shen, Benchao Shu, Yulin Xu, Heng Zhao, Yang Li, Yujie Li, Chuanchuan Zhuo, Naiqiang Zhuo","doi":"10.22540/JMNI-25-119","DOIUrl":"10.22540/JMNI-25-119","url":null,"abstract":"Objectives: This study aims to characterize a three-dimensional-printed hydroxyapatite (HA)/polycaprolactone (PCL) scaffold and assess its biocompatibility both in vitro and in vivo.Methods: A bionic, porous HA/PCL scaffold was fabricated using 3D printing, and its microstructure, porosity, hydrophilicity, and mechanical properties were evaluated through scanning electron microscopy and various assays. Bone marrow mesenchymal stem cells (BMSCs) and vascular endothelial progenitor cells (VEPCs) were co-cultured with the scaffold, and their proliferation and osteogenic differentiation were assessed using the Cell Counting Kit-8, ALP assays, and alizarin red staining. Osteogenic marker expression was analyzed via qRT-PCR. In vivo bone regeneration was evaluated through histological analysis of H&E and Masson's trichrome staining in a rat cranial defect model.Results: The average pore size of the scaffold was 462.00 ± 100.389 μm, with a porosity of 53%, a water absorption expansion rate of 5.10%, a contact angle of 94.55°, an elastic modulus of 53.82 MPa, and a compressive strength of 6.10 MPa. ALP activity and qRT-PCR analysis of osteogenic markers (BMP2, OCN, Runx2) showed significant upregulation in cells co-cultured with the scaffolds. In vivo experiments demonstrated enhanced bone regeneration and collagen deposition in the HA/PCL scaffold group.Conclusion: The results suggest that the HA/PCL scaffold promotes osteogenic differentiation and bone regeneration, making it suitable for bone tissue engineering applications.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"25 1","pages":"119-132"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Influencing Perioperative Occult Blood Loss in Elderly Hip Fracture Patients: A Retrospective Analysis. 影响老年髋部骨折患者围手术期隐血流失的因素：回顾性分析。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Lili Zong, Haiyan Zhou, Xue Zhao

{"title":"Factors Influencing Perioperative Occult Blood Loss in Elderly Hip Fracture Patients: A Retrospective Analysis.","authors":"Lili Zong, Haiyan Zhou, Xue Zhao","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To analyze the incidence and influencing factors of perioperative occult blood loss in elderly hip fracture patients.Methods: 145 cases of elderly hip fracture patients treated at our hospital from July 2022 to December 2023 were retrospectively analyzed. Patients were grouped based on the presence or absence of perioperative occult blood loss.Results: A total of 145 elderly hip fracture patients were included, with an average occult blood loss of 574.58±63.21 ml. Occult blood loss occurred in 42 cases, with an incidence rate of 28.97%, while 103 cases did not experience occult blood loss, with an incidence rate of 71.03%.Conclusion: Perioperative occult blood loss in elderly hip fracture patients is common and is associated with factors such as the type of surgery, anesthesia, postoperative drainage, and autologous blood transfusion. These factors constitute risk factors for perioperative occult blood loss in this patient population and warrant clinical attention and early preventive measures.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"394-399"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Hamstring Injuries and Vision on Posterior Chain Muscle Activation during Challenging Single-Limb Balance Control among Athletes with Hamstring Strain Injuries. 腿筋损伤和视力对腿筋拉伤运动员挑战性单肢平衡控制时后链肌激活的影响。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Amornthep Jankaew, Yih-Kuen Jan, Tai-Hua Yang, Hong-Wen Wu, Cheng-Feng Lin

{"title":"Influence of Hamstring Injuries and Vision on Posterior Chain Muscle Activation during Challenging Single-Limb Balance Control among Athletes with Hamstring Strain Injuries.","authors":"Amornthep Jankaew, Yih-Kuen Jan, Tai-Hua Yang, Hong-Wen Wu, Cheng-Feng Lin","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: This study investigated the impact of hamstring strain injuries (HSI) and vision on muscle recruitment and postural control in athletes with HSI.Methods: Fourteen athletes with HSI and fourteen healthy controls performed a single-leg balance task under eyes-closed and eyes-open conditions while leaning to the maximum forward and backward. The root-mean-square electromyography (EMG), median frequency, and center of pressure (COP) trajectories were calculated for 15 seconds. A two-way repeated measures ANOVA was conducted to assess differences between the groups and eye conditions.Results: Individuals with HSI exhibited lower hamstring activation during postural leans in the lateral hamstring (p = 0.009) during forward lean and both lateral (p = 0.001) and medial hamstring (p < 0.001) during backward lean. There were no significant changes in median frequency between the groups. Consequently, this resulted in a greater sway range and a larger 95% confidence ellipse area. The eye conditions primarily affected EMG frequency and COP parameters during leaning in both directions.Conclusion: Athletes with HSI exhibit a persistent deficit in hamstring activation, adversely affecting their postural control. These muscle impairments may compromise balance control and may impact sports performance. Therefore, implementing balance training programs should be considered in clinical rehabilitation for HSI.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"343-352"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI Findings of Bilateral Anterior Tarsal Tunnel Syndrome - A Case Report. 双侧跗骨前隧道综合征的MRI表现1例。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Yi Yan, David Wang, Vishal Kalia, Gregory Garvin

引用次数: 0

Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro. 吲哚美辛在体外缓解骨关节炎进展的潜在作用。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Xin Zhao, Tengfei Wang, Na Li, Zhen Meng, Weiling Wang, Bo Wang, Dalu Song

{"title":"Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.","authors":"Xin Zhao, Tengfei Wang, Na Li, Zhen Meng, Weiling Wang, Bo Wang, Dalu Song","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To elucidate how indomethacin may slow the progression of osteoarthritis (OA).Methods: Chondrocytes were treated with IL-1β (10 ng/mL) for 12 hours to create an in vitro model of OA. Following this, 10 μM of indomethacin was added to the IL-1β-treated chondrocytes for an additional 4 hours to evaluate its effects on inflammation, anabolism, catabolism, apoptosis, and autophagy using ELISA, western blot, immunofluorescence and flow cytometry, respectively.Results: IL-1β significantly stimulated inflammatory responses, hampered anabolic processes, induced catabolic activity, accelerated apoptosis, and inhibited autophagy in chondrocytes, as well as activated the PI3K/AKT/mTOR signaling pathway. However, treatment with indomethacin reversed the effects of IL-1β stimulation on chondrocytes and simultaneously suppressed the activation of the PI3K/AKT/mTOR signaling pathway.Conclusions: Our findings indicate the mechanism of action of indomethacin in mitigating OA progression, indicating that it can inactivate the PI3K/AKT/mTOR signaling pathway, thereby regulating inflammation, metabolism, apoptosis, and autophagy in chondrocytes, which attenuates the development of OA.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"409-419"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Physical Fitness in Children and Adolescents Within the Past 18 Years (DONALD Study). 过去18年儿童和青少年身体健康趋势（DONALD研究）

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Kim Ramona Wloka, Ute Alexy, Nina Reinhart, Evelyn Alberg, Kyriakos Martakis, Eckhard Schoenau, Ibrahim Duran

{"title":"Trends in Physical Fitness in Children and Adolescents Within the Past 18 Years (DONALD Study).","authors":"Kim Ramona Wloka, Ute Alexy, Nina Reinhart, Evelyn Alberg, Kyriakos Martakis, Eckhard Schoenau, Ibrahim Duran","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the trends in physical fitness in children and adolescents.Method: The present study focusses on a longitudinal analysis of the single two-legged jump (S2LJ) from children and adolescents, who participated in the DONALD study from 2004 till 2022. P max/body mass (power, surrogate for muscular performance), V max (bounce speed, surrogate for coordination), F max/body mass (force, surrogate for muscular strength) and <math> <mfrac><msub><mi>V</mi> <mi>max</mi></msub> <mrow><msub><mi>F</mi> <mi>max</mi></msub> <mo>/</mo> <mi>BM</mi></mrow> </mfrac> </math> (Nerve-Muscle Index, surrogate for jump efficiency) were examined by linear mixed models and propensity-score(PS)-matching analysis.Results: Data from 1,485 measurements from males and 1,445 from females were included. Mean age was 10.9 years for males and 11.4 years for females. The range of the number of repeated S2LJ was 1 to 8, the median was 3. In PS-matching analysis, there was a dose-effect relationship between the test date and the S2LJ parameters in such a way that P max/body mass and F max/body mass decreased with more recent test dates (effect size at a difference in the test date of 1.7 decades: 0.25 - 0.3) whereby V max and <math> <mfrac><msub><mi>V</mi> <mi>max</mi></msub> <mrow><msub><mi>F</mi> <mi>max</mi></msub> <mo>/</mo> <mi>BM</mi></mrow> </mfrac> </math> showed no consistent trend.Conclusion: Motor performance in children, assessed by the S2LJ, has decreased over the last two decades, mainly due to lower muscular strength, while motor efficiency and coordination seemed to be unchanged.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"336-342"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of Osteoporosis Clinical Risk Assessment Tools in Postmenopausal Women Aged 50-64. 50-64岁绝经后妇女骨质疏松临床风险评估工具的比较评价

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Konstantinos Chlapoutakis, Christos Baltas, Antonios Galanos, Maria Froudaki, Alexia Balanika

{"title":"Comparative Evaluation of Osteoporosis Clinical Risk Assessment Tools in Postmenopausal Women Aged 50-64.","authors":"Konstantinos Chlapoutakis, Christos Baltas, Antonios Galanos, Maria Froudaki, Alexia Balanika","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: To assess the performance of five osteoporosis clinical risk assessment tools (SCORE, ORAI, ABONE, OST and OSIRIS), in a subgroup of young postmenopausal women aged 50-64, who underwent DXA screening.Methods: The above-mentioned osteoporosis risk assessment tools were calculated for 258 young postmenopausal women (aged 50-64) who had a DXA scan, in Crete/Greece.Results: Patients with a T-score ≤ -2.5 or a T-score ≤ -2.0 had a statistically significant higher value of SCORE, ORAI and ABONE and a lower value of OST, OSIRIS, and OSIRIS Adjusted Score, compared to the patients with T-score > -2.5 and T-score > -2.0, respectively. ORAI (T-score≤ -2.0) and OST (T-score≤ -2.5) demonstrated the highest sum of sensitivity and specificity. CHAID analysis further confirmed the relative significance of the OST tool in the osteoporosis group (T-score≤ -2.5 vs. T-score > -2.5), for a cut-off of 2.8. In the other group (T-score ≤ -2.0 vs T-score > -2.0) the ORAI score showed a significantly important relationship for a cut-off of 8.Conclusion: OST, despite its performance limitations, correlates best with the DXA measurements of young (50-64), postmenopausal osteoporotic women, a fact which may suggest its' potential role as a screening tool in this specific age group.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"377-384"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Maohuoside A on AMPK Activation in Rats with Osteoarthritis Induced by Anterior Cruciate Ligament Transection. 毛藿香苷A对前交叉韧带断裂所致骨关节炎大鼠AMPK活化的影响。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Hongwei Wang

{"title":"Effects of Maohuoside A on AMPK Activation in Rats with Osteoarthritis Induced by Anterior Cruciate Ligament Transection.","authors":"Hongwei Wang","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To explore the therapeutic effects of Maohuoside A (MHA) on rats with osteoarthritis (OA) induced by anterior cruciate ligament transection, and to analyze its impact on the activation of adenosine monophosphate-activated protein kinase (AMPK).Methods: Sprague-Dawley male rats were divided into six groups: Sham, OA, L-MHA, M-MHA, H-MHA, and H-MHA + Compound C (n = 12 per group). The Sham group had sham surgery, while the OA, L-MHA, M-MHA, and H-MHA groups underwent OA via ACL severing. L-MHA, M-MHA, and H-MHA groups received low, moderate, and high doses of Maohuoside A, respectively, and the H-MHA + Compound C group received high-dose Maohuoside A plus Compound C. Hematoxylin-eosin (HE) staining and Safranin O/Fast Green staining were used to assess articular cartilage damage and degeneration, and the OARSI score was used to evaluate the extent of cartilage degeneration.Results: Compared with the OA group, the L-MHA, M-MHA, and H-MHA groups showed decreased OARSI scores, increased relative levels of Bcl-2 mRNA, decreased relative levels of Bax mRNA, reduced serum levels of IL-1β, IL-6, and TNF-α, increased relative levels of Collagen II mRNA, decreased relative levels of MMP-13 mRNA, and increased relative levels of BMP2, Runx2, and Osterix mRNA. Additionally, the relative level of cartilage AMPKα (Thr172) phosphorylation increased (P<0.05).Conclusion: This study suggests that Maohuoside A exerts anti-osteoarthritis (OA) effects by activating AMPK.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"400-408"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Commentary on: "The Diagnostic Role of Adding the Hoffman Reflex for L5 Radiculopathy in the Electrodiagnostic Laboratory: A Cross-sectional Study". 对“在电诊断实验室中加入Hoffman反射对L5神经根病的诊断作用：一项横断面研究”评论的回应。

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Hasan Kara, Elif Balevi Batur, Abdulvahap Kahveci, Onur Karacif, Önder Murat Özerbil, İlknur Albayrak Gezer, Funda Levendoğlu, Murat Zinnuroğlu

引用次数: 0

CYR61 as a Potential Apoptosis Biomarker in Osteoarthritis with Comorbidities. CYR61作为骨关节炎合并症的潜在凋亡生物标志物

IF 1.7 4区医学

Journal of musculoskeletal & neuronal interactions Pub Date : 2024-12-01

Murat Tokus, Hakan Cicek, Hüseyin Ates, Cagil Coskun, Yusuf Dogus, Figen Cicek

{"title":"CYR61 as a Potential Apoptosis Biomarker in Osteoarthritis with Comorbidities.","authors":"Murat Tokus, Hakan Cicek, Hüseyin Ates, Cagil Coskun, Yusuf Dogus, Figen Cicek","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Obesity and diabetes mellitus (DM) are major risk factors for osteoarthritis (OA), but it remains unclear how comorbidity affects apoptosis signaling in OA. This study investigated the effect of metabolic diseases on apoptosis and apoptosis-related intracellular and extracellular signaling in OA.Methods: Excision materials of human articular cartilage from total knee arthroplasties were collected. The samples were divided into four groups as, control OA, OA+DM, OA+Obese, and OA+DM+obesity. Protein activities were determined using Western blot and ELISA.Results: Caspase-3 levels were significantly increased in chondrocytes in which OA was associated with DM or obesity. However, an increase in Bcl-2 activity was also observed in these comorbidities. The increased levels of CaMKII in the same groups also indicate an increase in cellular activity in comorbidities. While IL-6 and TNF-α did not show significant changes, matrix regulatory protein CYR61 levels reflected the intracellular apoptotic activity.Conclusion: Metabolic diseases have a stimulatory effect on the etiopathology of osteoarthritis by enhancing cellular signaling towards apoptosis and that matrix signaling proteins may play a key role in regulating these effects. Examining OA with its accompanying diseases will lead to a better understanding of the cellular mechanisms that differ in OA.","PeriodicalId":16430,"journal":{"name":"Journal of musculoskeletal & neuronal interactions","volume":"24 4","pages":"385-393"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0