通过 pQCT 对患有疾病的儿童进行小腿测量的精度误差：骨密度、质量、尺寸、力学参数和软组织成分。

IF 1.7 4区医学 Q4 NEUROSCIENCES

Journal of musculoskeletal & neuronal interactions Pub Date : 2025-03-01 DOI:10.22540/JMNI-25-018

Maciej Jaworski, Maria Kobylińska

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引用次数: 0

摘要

目的：周边定量计算机断层扫描（pQCT）是目前儿科密度测量领域发展最快的方法之一，但其在儿童中的准确性尚不清楚。本研究的目的是评估患有疾病的儿童骨密度、质量、尺寸、强度和力学参数以及软组织组成的精度误差。方法：采用strategy XCT 2000L仪器。测量部位分别为小腿长度的4%、14%、38%和66%。研究组由60例患者（30例女孩）组成，年龄为5岁至18岁。结果：相对精度误差（CV%RMS）从胫骨38%皮质骨密度的0.25%到脂肪横截面积与肌肉横截面积之比的5.49%。最小显著变化（LSC）分别从0.70%到15.20%。已观察到精度误差与体型之间的弱到中等相关性，r从- 0.43到0.71。结论：本研究显示pQCT方法在有疾病的儿童下肢是一种相对精确的技术。获得的结果为设计和解释有医疗条件的儿童的pQCT研究提供了可实现的基础。

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Precision Errors of Lower Leg Measurement by pQCT in Children With Medical Conditions: Bone Density, Mass, Dimensions, Mechanostat Parameters and Soft Tissue Composition.

Objectives: The one of the developing methods in paediatric densitometry field is peripheral quantitative computed tomography (pQCT), however, very little is known about its precision in children. The aim of presented study was to evaluate the precision errors for bone density, mass, dimensions, strength and mechanostat parameters as well as for soft tissue composition in children with medical conditions.

Methods: Stratec XCT 2000L apparatus was used. The measurement sites were 4%, 14%, 38% and 66% of the lower leg length. The study group comprised of 60 patients (30 girls) aged 5,0-18,0 yrs.

Results: Relative precision errors (CV%RMS) were from 0,25% for tibia 38% cortical bone density to 5,49% for fat cross-sectional area to muscle cross-sectional area ratio. Least significant change (LSC) was from 0,70% to 15,20%, respectively. Weak to moderate correlations between precision errors and body size, with r from -0,43 to 0,71, have been observed.

Conclusion: Presented study revealed pQCT method at the lower leg in children with medical conditions as relatively precise technique. Obtained results provides an attainable basis for design and interpretation of pQCT studies in children with medical conditions.

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来源期刊

Journal of musculoskeletal & neuronal interactions NEUROSCIENCES-PHYSIOLOGY

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Musculoskeletal and Neuronal Interactions (JMNI) is an academic journal dealing with the pathophysiology and treatment of musculoskeletal disorders. It is published quarterly (months of issue March, June, September, December). Its purpose is to publish original, peer-reviewed papers of research and clinical experience in all areas of the musculoskeletal system and its interactions with the nervous system, especially metabolic bone diseases, with particular emphasis on osteoporosis. Additionally, JMNI publishes the Abstracts from the biannual meetings of the International Society of Musculoskeletal and Neuronal Interactions, and hosts Abstracts of other meetings on topics related to the aims and scope of JMNI.