Journal of Medical Biochemistry最新文献_第7页

YAP drives the development of cardiovascular disease in patients with rheumatoid arthritis YAP驱动类风湿关节炎患者心血管疾病的发展

4区医学

Journal of Medical Biochemistry Pub Date : 2023-09-20 DOI: 10.5937/jomb0-45932

Guozhu Che, Ying Liu, Na Zhang, Jing Zhao

{"title":"YAP drives the development of cardiovascular disease in patients with rheumatoid arthritis","authors":"Guozhu Che, Ying Liu, Na Zhang, Jing Zhao","doi":"10.5937/jomb0-45932","DOIUrl":"https://doi.org/10.5937/jomb0-45932","url":null,"abstract":"Background: To assess the influence of serum level of YAP on laboratory examination findings, imaging findings and disease activity of rheumatoid arthritis patients combined cardiovascular disease (RA-CVD).  Methods: RA-CVD patients (n=60), RA-nCVD patients (n=60) and healthy subjects (n=60) were recruited. Serum levels of YAP in them were detected by qRT-PCR. Their baseline characteristics were analyzed and compared. Disease activity, CVD risk factors and imaging findings in RA-CVD and RA-nCVD patients were evaluated and compared. In addition, potential influences of YAP on disease activity, CVD risk factors and imaging findings in RA-CVD patients were assessed.  Results: RA-CVD patients had higher levels of ERS, anti-CCP, RF, HDL-C, CRP, FRS, BNP, LA, LVs, LVd and cIMT, and lower level of EF in comparison to RA-nCVD patients. Serum level of YAP was higher in RA-CVD patients than that of RA-nCVD patients and healthy subjects. YAP level was positively correlated to DAS28, TG, CRP, PLT, FRS, BNP and cIMT in RA-CVD patients.  Conclusion: Serum level of YAP increases in RA-CVD patients. YAP is a potential factor driving the development of CVD in RA patients through regulating inflammatory response, lipid metabolism, glycometabolism and thrombosis.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136309098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical observation of laparoscopic sleeve gastrectomy and metformin treatment in obese PCOS patients 腹腔镜套筒胃切除术联合二甲双胍治疗肥胖型多囊卵巢综合征的临床观察

4区医学

Journal of Medical Biochemistry Pub Date : 2023-09-13 DOI: 10.5937/jomb0-44411

Qingya Ma, Xiaojing He, Zijie Fu, Xiaodong Ren, Ranran Sun, Siqi Zhu, Xiaodong Li, Yahui Bian

{"title":"Clinical observation of laparoscopic sleeve gastrectomy and metformin treatment in obese PCOS patients","authors":"Qingya Ma, Xiaojing He, Zijie Fu, Xiaodong Ren, Ranran Sun, Siqi Zhu, Xiaodong Li, Yahui Bian","doi":"10.5937/jomb0-44411","DOIUrl":"https://doi.org/10.5937/jomb0-44411","url":null,"abstract":"Background: to observe the basic metabolic characteristics of obese patients with PCOS, and observe and compare the effect of laparoscopic sleeve gastrectomy and metformin treatment after 3 months. Methods: In January to December 2018, the Second Hospital of Hebei Medical University selected 104 women who were classified as obese with a BMI of 28kg/cm2 or higher and had PCOS. They were divided into obese PCOS group (53 cases) and obese non-pcos group (51 cases). Results: 1. There was no significant difference in waist circumference and WHR between patients who are obese with PCOS and patients who are obese without PCOS (P > 0.05).Obese PCOS patients were significantly higher in AMH, LH/FSH, T, FAI, homa-ir, TG, LDL, apo-b and uric acid than the group of non-PCOS patients who were obese. (P<0.05). The SHBG levels of obese patients with PCOS were obviously lower when contrasted with the levels in obese patients without PCOS (P < 0.05). 2. Body weight, BMI, INS, homa-ir and TG of obese PCOS patients were significantly decreased 3 months after laparoscopic sleeve gastrectomy compared with that before surgery (P < 0.05). After three months of medical treatment with metformin, the patients' HOMA-IR was obviously reduced when contrasted with the pre-treatment HOMA-IR levels (P < 0.05), and there was no significant difference in the improvement degree of homa-ir between the two groups (P > 0.05). Conclusion: 1. Obese patients with PCOS demonstrated higher expression of AMH, LH/FSH, T, SHBG, and FAI when contrasted with the control group. Additionally, they experienced more severe insulin resistance and lipid metabolism disorders. 2. The weight and BMI of obese PCOS patients were significantly decreased after weight loss, while IR and blood lipid were significantly improved, while IR was improved in metformin group, and no significant discrepancy was observed in the degree of improvement of insulin resistance between both groups.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135785789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIFFERENT DOSES OF RECOMBINANT FSH AND DETERMINING PARAMETERS OF OXIDATIVE STRESS 不同剂量重组卵泡刺激素对氧化应激参数的影响

4区医学

Journal of Medical Biochemistry Pub Date : 2023-09-11 DOI: 10.5937/jomb0-46156

Lidija Tulić, None Ivan, Jelena Stojnic, Jovan Bila, Zeljka Vukovic, Boba Kotlica

{"title":"DIFFERENT DOSES OF RECOMBINANT FSH AND DETERMINING PARAMETERS OF OXIDATIVE STRESS","authors":"Lidija Tulić, None Ivan, Jelena Stojnic, Jovan Bila, Zeljka Vukovic, Boba Kotlica","doi":"10.5937/jomb0-46156","DOIUrl":"https://doi.org/10.5937/jomb0-46156","url":null,"abstract":"Background: This study aimed to examine if there is a connection between recombinant FSH dose and OS parameters in serum and the impact on IVF outcome. \u0000Methods: This study consisted of 101 participants that went through IVF procedures. Parameter that were tested are SOD, SH groups and MDA. Serum samples were drawn before stimulation and on the last day of ovarian stimulation. \u0000Results: Two groups were formed according to the dose of gonadotropins (rFSH). In both groups there were no significant differences in live–birth rate and miscarriage. In both groups mean serum MDA and SH-groups were significantly higher after ovarian stimulation, but mean serum SOD was significantly lower when compared to values before stimulation. There were less patients without OS before stimulation. \u0000Conclusion: Our results suggest that there is a difference in serum concentration in groups SOD, SH groups and MDA at the beginning and at the end ovarian stimulation. On the other hand, dose of rFSH is not related with change of parameters for oxidative stress, quality of oocytes, embryos, fertilization, pregnancies, and miscarriage rate. Patients without oxidative stress before the IVF procedure needed lower doses of gonadotropins during stimulation. \u0000Keywords: in vitro fertilization, oxidative stress, gonadotropin dose","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on Medical Information Mart for Intensive Care database: A cross-sectional study 基于重症监护医学信息集市数据库的急性心肌梗死患者甘油三酯-葡萄糖指数与急性肾损伤的相关性横断面研究

4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-30 DOI: 10.5937/jomb0-45219

Zihan Jin, Lu Xiao, Xinyi Xu, Changhong Miao, Yi Liu

{"title":"Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on Medical Information Mart for Intensive Care database: A cross-sectional study","authors":"Zihan Jin, Lu Xiao, Xinyi Xu, Changhong Miao, Yi Liu","doi":"10.5937/jomb0-45219","DOIUrl":"https://doi.org/10.5937/jomb0-45219","url":null,"abstract":"Background: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two. Methods: Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model. Results: Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk (odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P < 0.001). Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk (OR = 2.99, 95% CI = 1.64 to 5.46, P < 0.001). The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313). Conclusion: In patients with AMI, the incidence of TyG and AKI is closely related. Nevertheless, further studies are needed to verify the finding.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136144039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the effect of vitamin K1 prophylaxis on newborn screenings tests in newborns. 维生素K1预防在新生儿筛查中的作用研究。

IF 2.5 4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI: 10.5937/jomb0-40162

Murat Caglayan, Ataman Gonel, Cuneyt Tayman, Ufuk Cakir, Ismail Koyuncu, Ebru Temiz, Yasemin Sert

{"title":"Investigation of the effect of vitamin K1 prophylaxis on newborn screenings tests in newborns.","authors":"Murat Caglayan, Ataman Gonel, Cuneyt Tayman, Ufuk Cakir, Ismail Koyuncu, Ebru Temiz, Yasemin Sert","doi":"10.5937/jomb0-40162","DOIUrl":"10.5937/jomb0-40162","url":null,"abstract":"Background: Routine screening for hereditary disorders in newborns includes screening for treatable metabolic and endocrine disorders, such as biotidinase deficiency, galactosemia, maple syrup urine disease, hypothyroidism, and cystic fibrosis. Incorrect test results may be encountered due to the use of vitamin K1. To investigate the interference effect of vitamin K1 on neonatal screening tests and to raise awareness of erroneous measurements.Methods: Heel blood samples were taken from 25 newborns born in a neonatal intensive care unit. Dry blood C0, C2, C3, C4, C4DC, C5:1, C5OH, C5DC, C6, C6DC, C8, C8:1, C8DC, C10, C10:1, C10DC, C12, C14, C14:1, C14:2, C16, C16:1, C18, C18:1, C18:2, C18:OH, methylglutaryl, valine, leucine/isoleucine, methionine, phenylalanine, argininosuccinic acid, aspartate, alanine, arginine, citrulline, glycine, ornithine, and glutamate tests were studied using the tandem mass spectrometry (MS) method. The results of the heel blood samples obtained before and after the application of vitamin K1 (Phyto menadione) were compared.Results: In two studies conducted with in vitro and in vivo tests, C0, C2, C3, C4, C4DC, C5, C5OH, C6, C8, C10, C10:1, C14, C16, C16:1, C18, C18:1, methylglutaryl, phenylalanine, argininosuccinic acid, tyrosine, aspartate, arginine, citrulline, glycine, and glutamine were all significantly elevated (p < 0.05).Conclusions: Heel blood samples may yield false results due to vitamin K1 administration. In the case of doubtful results, a new sample should be taken and the measurement should be repeated.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"42 3","pages":"376-382"},"PeriodicalIF":2.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the relationship between endothelial nitric oxide synthase T786C polymorphism and PSA, PSA derivatives, and prostate cancer in the Turkish population. 土耳其人群内皮型一氧化氮合酶T786C多态性与PSA、PSA衍生物和前列腺癌症关系的研究。

IF 2.5 4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI: 10.5937/jomb0-33122

Senay Balci, Serin Akbayir, Murat Bozlu, Lulufer Tamer

{"title":"Investigation of the relationship between endothelial nitric oxide synthase T786C polymorphism and PSA, PSA derivatives, and prostate cancer in the Turkish population.","authors":"Senay Balci, Serin Akbayir, Murat Bozlu, Lulufer Tamer","doi":"10.5937/jomb0-33122","DOIUrl":"10.5937/jomb0-33122","url":null,"abstract":"Background: Prostate cancer is a slowly progressing cancer. However, it has remained a major medical problem for affected men. Risk factors of prostate cancer include age, race, and prostate cancer family history. Prostate cancer may occur at different frequencies between ethnic populations and countries. Currently, studies on genetic risk factors in prostate cancer aetiology have been increasing. Due to the importance of changes in endothelial nitric oxide synthase in carcinogenesis, we aimed to reveal whether eNOS T786C polymorphism is associated with prostate cancer.Methods: Archival samples included in this study were whole blood samples taken from patients who were grouped according to prostate biopsy pathology results (BPH, n: 42; PCa, n: 48) and from healthy participants (controls, n:27). DNA was isolated from these whole blood samples and real-time polymerase chain reaction analysis was performed for endothelial nitric oxide synthase T786C polymorphism with LightCycler 480 II. Measured free and total prostate-specific antigen serum levels were evaluated retrospectively.Results: There was a statistical difference between patient-healthy control and control-healthy control groups regarding genotype distributions for eNOS T786C hism. Controls were more likely to have TC and CC genotypes and C alleles than the other two groups.Conclusions: Compared to other groups, the percentage of the eNOS786C allele in the control group was found to be higher. As a result of these data, it can be thought that carrying the allele may be protective against the disease.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"42 3","pages":"357-363"},"PeriodicalIF":2.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive role of biochemical markers on outcomes of severe COVID-19 patients admitted to intensive care unit. 生化标志物对重症监护病房收治的重症新冠肺炎患者预后的预测作用。

IF 2.5 4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI: 10.5937/jomb0-40641

Bosa Mirjanić-Azarić, Ivana Pejić, Smiljana Mijić, Aleksandra Pejčić, Anita Đurđević-Svraka, Dragan Svraka, Darija Knežević, Tatjana Milivojac, Nataša Bogavac-Stanojević

{"title":"The predictive role of biochemical markers on outcomes of severe COVID-19 patients admitted to intensive care unit.","authors":"Bosa Mirjanić-Azarić, Ivana Pejić, Smiljana Mijić, Aleksandra Pejčić, Anita Đurđević-Svraka, Dragan Svraka, Darija Knežević, Tatjana Milivojac, Nataša Bogavac-Stanojević","doi":"10.5937/jomb0-40641","DOIUrl":"10.5937/jomb0-40641","url":null,"abstract":"Background: The pandemic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) is a multi-system disease caused by a diffuse systemic process involving a complex interaction of the inflammatory, immunological and coagulative cascades. This study aims to identify the most effective biomarkers to predict poor outcome in intensive care unit (ICU) patients with severe COVID-19 disease.Methods: A single-centre retrospective observational study enrolled 69 deceased and 20 recovered patients treated in the ICU of the General Hospital Gradiska in the period from March 1, 2021. until April 1, 2022. We evaluated the leukocytes (WBC), lymphocytes (LYM), neutrophils (NEU), platelets (PLT), haemoglobin, neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In addition, we evaluated the IL-6, ferritin, CRP, D-dimer, magnesium, bilirubin and lactate dehydrogenase.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"42 3","pages":"513-523"},"PeriodicalIF":2.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis. 多发性硬化症期间维生素D缺乏和全身和中枢炎症的关系。

IF 2.5 4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI: 10.5937/jomb0-37676

Sawsan Feki, Manel Naifar, Mariem Dammak, Sabrina Majdoub, Salma Sakka, Ali Yesmine Ben, Hend Hachicha, Chokri Mhiri, Fatma Ayadi, Hatem Masmoudi

{"title":"Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis.","authors":"Sawsan Feki, Manel Naifar, Mariem Dammak, Sabrina Majdoub, Salma Sakka, Ali Yesmine Ben, Hend Hachicha, Chokri Mhiri, Fatma Ayadi, Hatem Masmoudi","doi":"10.5937/jomb0-37676","DOIUrl":"10.5937/jomb0-37676","url":null,"abstract":"Background: During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our aim is to analyze the status of VitD and its correlation with the circulating inflammation and the intrathecal humoral response during MS.Methods: We analyzed samples of 318 individuals: 108 MS patients and 210 controls. Determination of 25-(OH) VitD3 level in serum was made using electrochemiluminescence method. Circulating inflammatory cytokines (IL-6, IL-8, IL-10, TNF-a, IL12p70 and IL-1b) were investigated using Cytometer Bead Array Technology. The central humoral response was characterized using CSF isofocusing test and IgG Index calculation.Results: As expected, mean value of VitD was significantly lower in MS group (26 nmol/L) than in control group (34.75 nmol/L) (p=0.002), with a severe deficiency in 67% of MS patients. Mean value of VitD was significantly lower in MS female patients. Regarding cytokines, mean value of TNFa was significantly higher in MS patients with oligoclonal bands of IgG in the CSF. IL6 was positively correlated with IgG level in serum of MS patients.Conclusions: Our results support the association of VitD deficiency with MS, especially in female patients of our region. However, the vitamin level seems to not correlate with inflammatory cytokines nor with disability. Interestingly, TNFa and IL6 levels were correlated with the intrathecal synthesis of IgG and the circulating IgG level, respectively.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"42 3","pages":"364-375"},"PeriodicalIF":2.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation. 氧化应激、炎症和血脂异常对不同血糖调节水平患者影响的主成分分析。

IF 2.5 4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI: 10.5937/jomb0-39636

Maja Malenica, Aleksandra Klisić, Neven Meseldžić, Tanja Dujić, Tamer Bego, Jelena Kotur-Stevuljević

{"title":"Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation.","authors":"Maja Malenica, Aleksandra Klisić, Neven Meseldžić, Tanja Dujić, Tamer Bego, Jelena Kotur-Stevuljević","doi":"10.5937/jomb0-39636","DOIUrl":"10.5937/jomb0-39636","url":null,"abstract":"Background: The aim of the study was to explore the mutual relationship between oxidative stress, inflammation and metabolic biomarkers in subjects with prediabetes (PRE), newly diagnosed type 2 diabetes patients (NT2D) and overt type 2 diabetes (T2D) using principal component analysis (PCA) as a thorough statistical approach.Methods: Glycated hemoglobin, lipid parameters, inflammation (IL-6, CRP and fibrinogen) and oxidative stress markers pro-oxidants (AOPP, PAB, TOS) and antioxidants (PON1, tSHG, TAS) were measured. PCA was applied to explore the factors that the most strongly influenced glucoregulation.Results: A total of 278 subjects were (i.e., 37 PRE, 42 NT2D and 99 T2D) were compared with 100 healthy subjects as a control group (CG). PCA emphasized 4 different factors explaining 49% of the variance of the tested parameters: oxidative stress-dyslipidemia related factor (with positive loading of TG and tSHG, and with negative loading of HDL-c and TAS), dyslipidaemia related factor (i.e., total cholesterol and LDL-c, both with positive loading), Anthropometric related factor (i.e., waist and hip circumference, both with positive loading) and oxidative stressInflammation related factor (i.e., PAB, fibrinogen, and CRP all with positive loading). Out of these 4 factors, only oxidative stress - dyslipidaemia related factor showed a significant predictive capability towards poor glucoregulation. An increase in this factor by one unit showed a 1.6 times higher probability for poor glucoregulation.Conclusions: Redox imbalance (determined with lower TAS and higher tSHG), in addition to higher TG and lower HDLc was associated with poor glucoregulation.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"42 3","pages":"427-436"},"PeriodicalIF":2.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spexin level in acute myocardial infarction in the emergency department. Spexin水平在急诊科急性心肌梗死中的应用。

IF 2.5 4区医学

Journal of Medical Biochemistry Pub Date : 2023-08-25 DOI: 10.5937/jomb0-39485

Yahya Çiftçi, Mehtap Gurger, Evrim Gul, Mustafa Yilmaz, Selda Telo, Metin Atescelik, Goktekin Mehmet Cagri, Kobat Mehmet Ali

{"title":"Spexin level in acute myocardial infarction in the emergency department.","authors":"Yahya Çiftçi, Mehtap Gurger, Evrim Gul, Mustafa Yilmaz, Selda Telo, Metin Atescelik, Goktekin Mehmet Cagri, Kobat Mehmet Ali","doi":"10.5937/jomb0-39485","DOIUrl":"10.5937/jomb0-39485","url":null,"abstract":"Background: We aimed to determine the serum spexin level in patients with acute myocardial infarction (AMI) admitted to the emergency department.Methods: A total of 100 patients with AMI (50 with ST-segment elevation myocardial infarction (STEMI) and 50 with non-ST-segment elevation myocardial infarction (NSTEMI)) and 50 control group patients with non-cardiac chest pain were included in the study. A detailed anamnesis was taken, a physical examination was performed, and 12-lead electrocardiograms and venous blood samples were taken at the time of admission. Spexin levels were measured via enzyme-linked immunosorbent assay.Results: Serum spexin levels were significantly lower in the AMI group than in the non-cardiac chest pain group (p<0.001). There was no significant difference in serum spexin levels between STEMI and NSTEMI patients (p=0.83). In receiver operating curve analysis, we detected 58% sensitivity, 76% specificity, 82.9% positive predictive value, and 47.5% negative predictive value with an optimal cutoff value of 532 pg/mL for the diagnosis of AMI.Conclusions: In this study, serum spexin levels were significantly lower in AMI patients compared to patients with non-cardiac chest pain. The decrease in spexin levels suggests that it has the potential to be used as a diagnostic marker in AMI patients.","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"42 3","pages":"407-411"},"PeriodicalIF":2.5,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0