Journal of Medical Biochemistry最新文献

{"title":"Improved potassium reliability in whole blood through hemolysis detection on the novel GEM Premier 7000 blood gas analyzer.","authors":"Laura Pighi, Gian Luca Salvagno, Filippo Marcazzan, Mariateresa Rizza, Giuseppe Lippi","doi":"10.5937/jomb0-58604","DOIUrl":"10.5937/jomb0-58604","url":null,"abstract":"<p><strong>Background: </strong>Hemolysis is the most frequent preanalytical error in clinical laboratories, but its detection in point-of-care (POC) settings remains challenging due to the lack of sample separation. This study was planned to validate the hemolysis index (HI) threshold of GEM Premier 7000 blood gas analyzer for detecting hemolysis levels that may generate clinically significant interference in potassium measurement.</p><p><strong>Methods: </strong>Heparinized whole blood samples were collected from healthy volunteers and divided into six aliquots; one was used as non-hemolyzed control, while hemolysis was mechanically induced in the remaining five aliquots by repeated aspirations through a fine-gauge needle. HI and potassium were measured on GEM Premier 7000.</p><p><strong>Results: </strong>The final study population consisted of 18 volunteers. Both HI and potassium levels increased progressively and significantly with the number of fine-needle aspirations (p<0.001 for both). A strong positive correlation was observed between HI values and percentage increases in potassium concentration in hemolyzed aliquots (r=0.985, p<0.001). Receiver operating characteristic (ROC) curve analysis confirmed excellent diagnostic accuracy of HI in detecting potassium increases above the minimum total 7.4% allowable error threshold, with an area under the curve (AUC) of 1.00 and optimal cutoff of 102 mg/dL (0.94 sensitivity and 1.00 specificity). At the manufacturer-recommended 116 mg/dL threshold, the AUC was 0.95, with 0.89 sensitivity and 1.00 specificity.</p><p><strong>Conclusions: </strong>These results confirm that the novel GEM Premier 7000 blood gas analyzer provides accurate detection of hemolysis thresholds in whole blood that may impair potassium test reliability.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"915-918"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated interleukin-10, -22, -24, and -26 in serum samples of children with infectious mononucleosis.","authors":"Dalei Li, Kangwei Mao, Peiliang Luo, Ziqiang Zheng, Jiangyan Liu, Chenxi Zhang, Siyu Gu, Rui Zhang, Jun Sun, Juan Wang","doi":"10.5937/jomb0-54625","DOIUrl":"10.5937/jomb0-54625","url":null,"abstract":"<p><strong>Background: </strong>Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in serum samples of patients with infectious mononucleosis (IM) and the potential diagnostic values.</p><p><strong>Methods: </strong>Thirty children with IM were enrolled in the study, and serum samples were collected; 30 healthy children served as the controls. Serum samples from the patients and healthy controls were collected, and IL-10, -22, -24, and -26 were determined by the ELISA method. An automatic biochemical analyser detected the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Moreover, potential diagnostic values of IL-10, -22, -24 and -26 have been analysed using ROC curve analysis, and the correlation between the levels of IL-10, -22, -24 and -26 in patients was analysed. Correlation between IL-10, -22, -24, and -26 and ALT and AST were analysed.</p><p><strong>Results: </strong>IL-10, -22, -24, and -26 levels increased in serum samples of patients with IM compared to healthy controls. ROC analysis showed that the AUC of IL-10, -22, -24, and -26 were 0.8500, 0.7078, 0.8056, and 0.9167, respectively, suggesting that IL-10, -22, -24, and -26 were good biomarkers. Moreover, IL-10, -22, -24 and -26 levels were positively correlated with the ALT and AST of the patients.</p><p><strong>Conclusions: </strong>IL-10, -22, -24, and -26 were upregulated in the serum of patients with IM, suggesting they may function as potential biomarkers.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"776-783"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB) changes in elderly hip fracture patients after surgery and nutritional support.","authors":"Fangqin Jin, Qin Zhang, Jiangping Weng, Xuting Pan, Qinyan Dong, Yuping Zhao","doi":"10.5937/jomb0-55434","DOIUrl":"10.5937/jomb0-55434","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effects of nutritional support combined with stratified nursing under delirium risk assessment on immune function and postoperative delirium in elderly hip fracture patients.</p><p><strong>Methods: </strong>A total of 112 elderly hip fracture patients were divided into two groups: the study group (SG), which received stratified nursing and enteral nutrition, and the control group (CG), which received routine nursing with a normal diet. Key parameters were evaluated and compared, including serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB), postoperative delirium incidence, nutritional status, recovery time, and overall patient outcomes.</p><p><strong>Results: </strong>Compared to the CG, the SG demonstrated significant improvements in immune function, with increased IgA, IgG, and IgM levels, as well as higher haemoglobin, albumin, and total protein levels. The SG also experienced shorter hospital stays, earlier postoperative mobility, reduced postoperative delirium rates (1.79% vs. 14.29%), lower anxiety and depression scores, better sleep quality, and lower pain scores. Additionally, nursing satisfaction was significantly higher in the SG.</p><p><strong>Conclusions: </strong>Nutritional support combined with stratified nursing under delirium risk assessment effectively enhances immune function, reduces postoperative delirium, and accelerates recovery in elderly hip fracture patients. This approach may serve as a valuable strategy in postoperative management to improve patient outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"822-830"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of serum iPTH, ALP and serum markers levels in patients with secondary hyperparathyroidism receiving paricalcitol combined with cinacalcet.","authors":"Song Ruifang, Chen Fadong, Xue Zengqi, Lu Xiaozhen","doi":"10.5937/jomb0-55510","DOIUrl":"10.5937/jomb0-55510","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effect of combining paricalcitol with cinacalcet on the levels of intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) in patients with secondary hyperparathyroidism undergoing maintenance hemodialysis (MHD).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical records of 129 patients diagnosed with chronic kidney disease (CKD) and secondary hyperparathyroidism who received MHD between June and December 2022. The patients were categorised into three groups based on their treatment regimen: Group A (paricalcitol alone, n=43), Group B (cinacalcet alone, n=43), and Group C (combined paricalcitol and cinacalcet, n=43). Hemoglobin (Hb), serum albumin (Alb), calcium (Ca), phosphorus (P), iPTH, ALP, serum creatinine (Scr), and blood urea nitrogen (BUN) levels were measured at admission, 1 day, 3 months, and 6 months to compare the outcomes across the three groups.</p><p><strong>Results: </strong>No significant differences among the groups were observed in Hb and Alb levels at 1 day post-admission (P>0.05). However, after 3 and 6 months of treatment, Hb and Alb levels increased in all groups, with Group C showing the greatest improvement (P<0.05). iPTH, Ca, and P levels were similar across all groups on day 1 (P>0.05), but by 3 and 6 months, all groups showed reductions, with Group C having the lowest levels (P<0.05). Similarly, ALP, Scr, and BUN levels decreased in all groups over time, with Group C again demonstrating the greatest reduction (P<0.05).</p><p><strong>Conclusions: </strong>The combination of paricalcitol and cinacalcet was effective in reducing iPTH, calcium, phosphorus, and ALP and improving Hb and Alb levels in patients with secondary hyperparathyroidism on maintenance hemodialysis. This treatment approach offers significant benefits in managing SHPT.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"759-769"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of antioxidant markers (SOD, GSH, NO, Catalase) with ischemic stroke severity and recovery outcomes.","authors":"Chen Haonan, Zang Shuhan, Zhang Runlei, Chen Peilin, Wu Shengxian","doi":"10.5937/jomb0-57208","DOIUrl":"10.5937/jomb0-57208","url":null,"abstract":"<p><strong>Background: </strong>This randomised controlled trial aimed to investigate the relationship between antioxidant markers (Superoxide Dismutase [SOD], Glutathione [GSH], Catalase, and Nitric Oxide [NO]) and the severity of ischemic stroke in affected individuals.</p><p><strong>Methods: </strong>A single-blind randomised controlled trial was conducted from June 2022 to November 2024, including 364 patients aged 45-80 years diagnosed with ischemic stroke. Participants were randomly divided into two groups: Group A (n=193) received standard stroke rehabilitation therapy, while Group B (n=171) received additional antioxidant support. Serum levels of SOD, GSH, Catalase, and NO were measured. Stroke severity was evaluated using the modified Rankin Scale (mRS) and NIH Stroke Scale (NIHSS), with follow-up assessments at 2, 4, and 6 months post-treatment.</p><p><strong>Results: </strong>Among the 364 participants, 203 (55.7%) were male, and 161 (44.3%) were female, with a mean age of 67.3±12.2 years. Serum SOD levels were higher in the experimental group (16.3±3.7 U/mL) compared to the control group (12.5±4.1 U/mL, p=0.014). GSH levels were also significantly higher in the experimental group (178±31 mmol/L) than in the control group (145±26 mmol/L, p=0.032). NO levels were higher in the experimental group (42.1±8.6 mmol/L) than in the control group (35.4±7.3 mmol/L, p=0.021). Catalase levels were 52.3±11.1 U/mL in the experimental group and 49.6±10.2 U/mL in the control group, with no significant difference between the groups (p=0.213). Significant inverse correlations were found between SOD, GSH, and NO levels and stroke severity (p<0.05), but catalase showed no such correlation (p=0.513).</p><p><strong>Conclusions: </strong>This study identified a significant relationship between higher levels of SOD, GSH, and NO and improved stroke recovery, whereas catalase did not exhibit a meaningful association with stroke severity or functional outcomes. These findings highlight the potential role of specific antioxidant markers in stroke prognosis and recovery while suggesting that catalase may not play a critical role in ischemic stroke outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"895-904"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical value of serum sST2 and cfDNA in guiding evidence-based nursing care for children with severe pneumonia complicated by myocardial damage.","authors":"Meng Du, Haoran Jia, Tingting Zhao, Ye Liu, Dexing Wang, Weiwei Wang","doi":"10.5937/jomb0-52085","DOIUrl":"10.5937/jomb0-52085","url":null,"abstract":"<p><strong>Background: </strong>To investigate how serum sST2 and cfDNA can be used to inform evidence-based nursing practices for children with severe pneumonia and myocardial damage.</p><p><strong>Methods: </strong>100 children with severe pneumonia complicated with myocardial damage were recruited as research subjects. After assessing serum sST2 and cfDNA concentrations, the individuals were categorised into a control cohort (receiving standard treatment, n=50) and an experimental cohort (receiving evidence-based treatment guided by serum sST2 and cfDNA markers, n=50). Collected were the general details of the two patient groups. Biochemical analysis of patient serum sST2 and cfDNA changes was performed before and after care. Echocardiography was used to measure the left ventricular ejection fraction (LVEF) and left ventricular internal diameter (LVIDd) both before and after treatment of the patient. Levels of procalcitonin and C-reactive protein were assessed using enzyme-linked immunosorbent assay (ELISA) before and after patient treatment, while the white blood cell count in blood samples was determined using an automated haematology analyser. The patients' pneumonia resolution and length of hospital stay were compared. Patient satisfaction with care plans was compared through rating questionnaires.</p><p><strong>Results: </strong>The general information of the two groups of patients showed no significant difference (P>0.05). Before receiving nursing care, there were no significant variations in serum sST2 and cfDNA levels among the two patient groups (P>0.05). Following the nursing period, the observation group exhibited decreased serum sST2 and cfDNA levels compared to the control group (P<0.05). Before nursing care, there were no significant variations in left ventricular ejection fraction and left ventricular internal diameter in diastole among the two cohorts of patients (P>0.05). Following nursing, the observation group exhibited a higher LVEF than the control group and a smaller LVIDd (P<0.05). Before receiving nursing care, there were no significant variations in procalcitonin, hs-CRP, and white blood cell count between the two patient groups (P>0.05). Following care, the observation group exhibited decreased levels of procalcitonin, hs-CRP, and white blood cell count compared to the control group (P<0.05). The pneumonia remission and hospitalisation duration in the observation group were significantly shorter than in the control group (P<0.05).</p><p><strong>Conclusions: </strong>The importance of serum sST2 and cfDNA indicators in evidence-based nursing for children with severe pneumonia and myocardial damage is highlighted, showing significant improvement in treatment outcomes and patient satisfaction, confirming the crucial role of these biomarkers in enhancing nursing care plans.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"748-758"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum IL-6, IL-10, TNF-a changes in postpartum perineal oedema rehabilitation.","authors":"Lili Xue, Yaqiong Jiang, Yongli Guo, Hongyan Ma, Lingling Jiang, Xiaoyu Wang, Xinyi Kang, Ying Wang, Jiachen Cao, Liping Chen","doi":"10.5937/jomb0-56599","DOIUrl":"10.5937/jomb0-56599","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the effectiveness of manual lymphatic drainage (MLD) combined with abdominal breathing in rehabilitating postpartum perineal oedema and Serum IL-6, IL-10, TNF-a.</p><p><strong>Methods: </strong>A total of 172 primiparous women who delivered in our hospital between January 2022 and June 2023 were randomly assigned to either the observation group (n=86) or the control group (n=86). The control group received routine midwifery care, while the observation group received additional MLD and abdominal breathing training. Outcomes measured included pain levels, induration diameter, comfort, emotional state, recovery time, and clinical efficacy. Inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumour necrosis factor-alpha (TNF-a), were also assessed.</p><p><strong>Results: </strong>Both groups demonstrated significant reductions in Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores after treatment (P<0.05), with the observation group showing a greater decrease (P<0.05). The observation group exhibited a significantly shorter recovery time (3.6±1.8 days vs. 4.2±2.5 days, P<0.05) and reported higher comfort levels and lower pain scores than the control group (P<0.05). The effective treatment rate was 97.68% in the observation group, significantly higher than the 82.56% observed in the control group (P<0.05). Inflammatory markers, including IL-6 and TNF-a, showed a significant reduction in the observation group.</p><p><strong>Conclusions: </strong>Combining MLD and abdominal breathing reduces postpartum perineal oedema effectively, alleviates pain, and enhances recovery. It also lowers inflammatory markers (IL-6, TNF-a) and increases IL-10, promoting faster healing and improved maternal comfort.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"831-839"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of zoledronic acid versus denosumab on bone metabolism, inflammatory response, and immunoglobulins in breast cancer patients with bone metastases.","authors":"Xian Zhang, Jinfeng Tong, Zhi Wang, Hailong Yang, Pei Shi","doi":"10.5937/jomb0-56984","DOIUrl":"10.5937/jomb0-56984","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the effects of Zoledronic Acid (ZA) versus Denosumab (DEN) on bone metabolism, inflammatory response, and immunoglobulins in breast cancer (BC) patients with bone metastases.</p><p><strong>Methods: </strong>The potential study population consisted of 163 patients with bone metastases BC admitted from May 2023 to June 2024. Through propensity score matching (PSM), 122 patients were included, with 61 patients in the ZA group (treated with ZA) and 61 patients in the DEN group (treated with DEN). Levels of tartrate-resistant acid phosphatase 5b (TRACP-5b), bone glutamyl protein (BGP), bone alkaline phosphatase (BALP), and 25-hydroxyvitamin D3 (25(OH)D3) were measured before and after treatment. Additionally, bone mineral density (BMD) of the lumbar spine (L1-L4) and hip, as well as levels of inflammatory factors and immunoglobulins, were assessed.</p><p><strong>Results: </strong>After PSM, baseline characteristics were balanced between the ZA and DEN groups (P > 0.05). No significant difference was observed in post-treatment BMD between the two groups (P > 0.05). However, the DEN group showed significantly lower TRACP-5b and BGP levels and notably higher BALP and 25(OH)D3 levels compared to the ZA group (P <0.05). In contrast, the ZA group exhibited lower levels of inflammatory factors and higher immunoglobulin levels than the DEN group (P < 0.05). Regarding safety, a lower incidence of adverse reactions was determined in the DEN group versus the ZA group (P < 0.05).</p><p><strong>Conclusions: </strong>In the treatment of BC with bone metastases, DEN demonstrated superior benefits for bone metabolism, while ZA showed better regulation of inflammatory response and immune function.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"731-739"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum immune indicators including IgM, IgA, and IgG levels and quality of life of patients with gastrointestinal tumours during chemotherapy.","authors":"Mengchao Wan, Yunlong Wang, Lin Zeng, Zhiyong Zhou, Weirong Yao","doi":"10.5937/jomb0-56137","DOIUrl":"10.5937/jomb0-56137","url":null,"abstract":"<p><strong>Background: </strong>Patients with gastrointestinal tumours often experience malnutrition and compromised immune function during chemotherapy, leading to a significant decline in quality of life. This study aimed to evaluate the effects of dietary nursing interventions on the nutritional status, immune function, and quality of life in patients undergoing chemotherapy.</p><p><strong>Methods: </strong>A total of 100 patients with gastrointestinal tumours receiving chemotherapy from January 2023 to June 2024 were randomly divided into two groups: a control group (CG) and a study group (SG). Both groups received conventional nursing interventions, but the SG also received dietary nursing interventions focused on personalized nutrition, dietary habits, and gastrointestinal health. Nutritional status was assessed using body mass index (BMI), haemoglobin (HGB), serum albumin (ALB), and oral mucosal cell apoptosis rate. Immune function was evaluated by measuring immunoglobulin M (IgM), immunoglobulin A (IgA), and immunoglobulin G (IgG) levels. Quality of life was measured using the GQOL-74 scale.</p><p><strong>Results: </strong>After the nursing interventions, the SG showed significant improvements in BMI, HGB, ALB, and oral mucosal cell apoptosis rate compared to the CG (P<0.05). Additionally, IgM, IgA, and IgG levels were significantly higher in the SG (P<0.05). Quality of life scores, including physical, social, psychological, and material life, also improved significantly in the SG compared to the CG (P<0.05).</p><p><strong>Conclusions: </strong>Dietary nursing interventions significantly improved the nutritional status, immune function, and quality of life of patients with gastrointestinal tumours undergoing chemotherapy. These findings underscore the importance of incorporating dietary care into nursing practices for cancer patients to support their overall well-being and treatment outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"814-821"},"PeriodicalIF":1.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lactate-to-albumin ratio and shortand long-term mortality in critically ill patients with ischemic stroke: A retrospective analysis of the MIMIC-IV database.","authors":"Sisi Qin, Jijie Xiao, Shiqi Yuan, Huitao Zhang, Yang Liu, Ningjun Li, Songjin He, Li Kou","doi":"10.5937/jomb0-54979","DOIUrl":"10.5937/jomb0-54979","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a major cause of disability and cognitive deficits, with ischemic stroke (IS) being the most prevalent type, especially in critically ill patients in intensive care units (ICUs). The lactate-to-albumin ratio (LAR) has emerged as a potential predictor of disease outcomes, but its association with shortand long-term mortality in critically ill IS patients is unclear.</p><p><strong>Methods: </strong>This study analyzed data from 894 critically ill IS patients from the MIMIC-IV database, categorized into LAR tertiles. Clinical endpoints included ICU, hospital, and 30and 90-day all-cause mortality. Survival differences were assessed using Kaplan-Meier analysis. Cox proportional-hazards regression models and restricted cubic spline (RCS) analysis evaluated the association between LAR and mortality outcomes. Subgroup analyses examined the modifying effects of clinical characteristics on LAR's predictive value.</p><p><strong>Results: </strong>The ICU, hospital, 30-, and 90-day mortality rates were 15.0%, 22.3%, 28.2%, and 36.1%, respectively. Higher LAR levels were associated with reduced survival times and increased mortality risks in all endpoints. Multivariable Cox models confirmed LAR as an independent predictor of 30and 90-day mortality. RCS analysis indicated a linear relationship between LAR and ICU mortality (P = 0.109), and a non-linear association with hospital (P = 0.005), 30-day (P < 0.001), and 90-day mortality (P < 0.001). Subgroup analyses highlighted significant interactions for respiratory failure and GCS.</p><p><strong>Conclusions: </strong>LAR is a robust predictor of shortand longterm mortality in critically ill IS patients, offering clinicians a valuable tool for risk stratification and decision-making.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"453-469"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}