Journal of Medical Biochemistry最新文献

{"title":"Correlation analysis of the expression levels of serum endothelial cell adhesion molecule-1 and sirtuin 1 protein in acute respiratory distress syndrome.","authors":"Can Peng, Zhigang Sun, Yanyan Liu, Yougui Liu, Hao Zhao","doi":"10.5937/jomb0-61088","DOIUrl":"https://doi.org/10.5937/jomb0-61088","url":null,"abstract":"<p><strong>Background: </strong>To investigate the relationships among the expression levels of serum silencing information regulator 2-related enzyme 1 (SIRT1), endothelial cell-specific molecule-1 (ESM-1), and fibroblast growth factor-21 (FGF21) and treatment results in patients with acute respiratory distress syndrome (ARDS) associated with sepsis.</p><p><strong>Methods: </strong>A total of 140 patients with sepsis-related ARDS were selected and divided into a good-outcome group (96 patients) and a poor-outcome group (44 patients) based on treatment outcome. The levels of serum SIRT1, ESM-1, and FGF21 were compared between the two groups; the correlations between serum SIRT1, ESM-1, and FGF21 and disease severity and treatment outcome were analysed; and the predictive value of serum SIRT1, ESM-1, and FGF21 for treatment outcomes was evaluated.</p><p><strong>Results: </strong>Compared with those in the group with favourable outcomes, the serum SIRT1 level was lower, while the ESM-1 and FGF21 levels were significantly higher in the poor outcome group than in the good outcome group (P&lt;0.05). Serum SIRT1 levels decreased steadily in patients with mild, moderate, and severe illness, whereas ESM-1 and FGF21 levels increased consistently (P&lt;0.05). ESM-1 and FGF21 showed a positive association with illness severity (P&lt;0.05), whereas serum SIRT1 was negatively correlated (P&lt;0.05) with disease severity according to Spearman correlation analysis. Partial correlation analysis indicated that serum SIRT1, ESM-1, and FGF21 levels were significantly related to treatment outcomes in patients with sepsis-related ARDS (P&lt;0.05). The levels of serum SIRT1, ESM-1, and FGF21 and treatment outcomes were strongly linked (P&lt;0.05) in patients with sepsis-related ARDS. The areas under the curve (AUCs) for predicting treatment course in patients with ARDS associated with sepsis were 0.742 for SIRT1, 0.838 for ESM-1, and 0.796 for FGF21. The sensitivities were 77.27% and 70.45%, and the specificities were 64.58%, 81.25%, and 87.50%, respectively. For patients with sepsis-related ARDS, the combined AUC of the three markers for treatment outcome was 0.939, with a sensitivity of 88.64% and a specificity of 83.33%, significantly surpassing the individual predictive values of the three markers alone (P&lt;0.05).</p><p><strong>Conclusions: </strong>The levels of serum SIRT1, ESM-1, and FGF21 in patients with sepsis-related ARDS are strongly associated with both treatment efficacy and illness severity, can independently predict treatment outcomes, and have greater combined predictive value.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1364-1372"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of serum SERPINA3, CLEC2 and hs-CRP/ALB with major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in STEMI.","authors":"Yuncong Ma, Suxia Fang, Shasha Liu, Zhencong Jiang","doi":"10.5937/jomb0-62259","DOIUrl":"https://doi.org/10.5937/jomb0-62259","url":null,"abstract":"<p><strong>Background: </strong>To examine the main adverse cardiovascular events that occur in individuals who have had an acute ST-segment elevation myocardial infarction (STEMI) after receiving percutaneous coronary intervention (PCI), such as serum C-type lectin domain family member 2 (CLEC2), serine protease inhibitor family member A3 (SERPINA3), and high-sensitivity C-reactive protein/albumin (hs-CRP/ALB) levels.</p><p><strong>Methods: </strong>The STEMI group included 132 patients who were observed for 1 year after hospitalisation between January 2023 and September 2024. The patients were divided into two groups: the MACE group and the non-MACE group, based on whether MACE came after PCI. Additionally, the control group consisted of 68 healthy individuals who were physically examined at the hospital during the same time period. Using an enzyme-linked immunosorbent test, the levels of serum CLEC2, SERPINA3, hs-CRP and ALB were measured in each research participant, and the hs-CRP to ALB ratio was computed. After PCI, multivariate logistic regression was used to examine variables associated with MACEs in STEMI patients. Receiver operating characteristic (ROC) curves were used to analyse the predictive value of single and combined detection of serum CLEC2, SERPINA3, and hs-CRP/ALB for MACEs in STEMI patients after PCI.</p><p><strong>Results: </strong>The incidence of MACE after PCI in 132 STEMI patients was 31.06% (41/132). The levels of serum CLEC2, SERPINA3 and hs-CRP/ALB in the STEMI group were significantly greater than those in the control group (P&lt; 0.05). Independent risk factors for MACEs following PCI in STEMI patients included age &gt;62 years, Killip grade &gt; grade III, cardiac troponin I level &gt;1.7 ng/mL, CLEC2 level &gt;155 pg/mL, SERPINA3 level &gt;350 ng/L, and hs-CRP/ALB &gt;0.50 (P&lt; 0.05), while left ventricular ejection fraction &gt;50% was an independent protective factor. The area under the ROC curve (0.856) of the combined detection of serum CLEC2, SERPINA3, and hs-CRP/ALB for the prediction of MACEs in STEMI patients after PCI was greater than that of the individual detection of each index.</p><p><strong>Conclusions: </strong>Serum CLEC2 levels &gt;155 pg/mL, SERPINA3 levels &gt;350 ng/L, and hs-CRP/ALB&gt;0.50 are closely related to the occurrence of MACEs in STEMI patients after PCI and can be used as auxiliary predictive indicators for the occurrence of MACEs in STEMI patients after PCI.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1259-1268"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory diagnostics of chronic kidney disease in Serbia: Current practice and priorities for harmonisation.","authors":"Vera Lukić, Dušica Mrdaković, Neda Milinković","doi":"10.5937/jomb0-65067","DOIUrl":"10.5937/jomb0-65067","url":null,"abstract":"<p><strong>Background: </strong>To assess current laboratory practices in chronic kidney disease (CKD) diagnostics in Serbia and identify areas requiring harmonisation in line with national and international guidelines.</p><p><strong>Methods: </strong>A cross-sectional, questionnaire-based survey was conducted between June and August 2025, with support from the Serbian Society of Medical Biochemists, which distributed invitations to its members working in medical laboratories across Serbia. Eighty-three laboratories participated (response rate 84.7%), representing primary, secondary, tertiary, and private healthcare sectors. Data were analysed descriptively.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1276-1285"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of miR-3178 in non-small cell lung cancer patients.","authors":"Deng Huang, Yingfang Ma, Haizhen Yu, Shizhen Li, Ling Zhou","doi":"10.5937/jomb0-57060","DOIUrl":"10.5937/jomb0-57060","url":null,"abstract":"<p><strong>Background: </strong>Non-small cell lung cancer (NSCLC) is a malignant tumour with high morbidity and mortality, with a low survival rate and poor prognosis. This study aims to explore the diagnostic and prognostic value of miR-3178 in NSCLC.</p><p><strong>Methods: </strong>The study included 118 NSCLC patients and 97 healthy subjects. RT-qPCR measured miR-3178 and MIB2 in serum or cell lines. c 2 tests linked miR-3178 to clinico-pathological features. ROC, Kaplan-Meier, and Cox analyses evaluated the diagnostic and prognostic significance of miR-3178 and MIB2.</p><p><strong>Results: </strong>Compared to the control group, the expression level of miR-3178 was significantly reduced, while MIB2 expression was notably elevated in NSCLC patients. The expression of miR-3178 is significantly correlated with the TNM stage and LNM in NSCLC patients. NSCLC patients with higher miR-3178 expression levels exhibit significantly higher 5-year overall survival rates. Furthermore, TNM stage, miR-3178 expression, and MIB2 expression are independent risk factors that influence the prognosis of NSCLC. MIB2 serves as a target gene of miR-3178, and its expression levels display a significant negative correlation. When diagnosing NSCLC solely based on miR-3178, the AUC is 0.838, the diagnostic sensitivity and specificity were 83.1% and 72.2% , respectively; for MIB2 alone, the AUC is 0.818, the sensitivity and specificity were 76.3% and 72.2% ; however, when miR-3178 and MIB2 are combined for diagnosis, the AUC increases to 0.903, the sensitivity and specificity were 84.8% and 83.5%.</p><p><strong>Conclusions: </strong>The downregulation of miR-3178 and upregulation of MIB2 are associated with the progression and deterioration of NSCLC patients, indicating poor prognosis. miR-3178 targets MIB2, and their combined diagnosis can enhance the diagnostic value for NSCLC, potentially reducing the risk of adverse outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1332-1341"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of circulating inflammatory biomarkers by SGLT2 inhibitors in diabetic patients with acute myocardial infarction: A quantitative meta-analysis of laboratory evidence.","authors":"Jia Xu, Yuanhong Jie, Tao Dong, Qi Li, Xiaobing Liu","doi":"10.5937/jomb0-65034","DOIUrl":"10.5937/jomb0-65034","url":null,"abstract":"<p><strong>Background: </strong>Acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM) is characterized by an exaggerated inflammatory response and adverse myocardial remodeling. Sodium-glucose cotransporter-2 inhibitors (SGLT2-I) have demonstrated cardiometabolic benefits; however, their effects on circulating inflammatory biomarkers in diabetic AMI remain inconsistent. This meta-analysis aimed to quantitatively evaluate laboratory-based evidence regarding the modulation of key inflammatory markers by SGLT2-I therapy in this high-risk population.</p><p><strong>Methods: </strong>A systematic search of PubMed, ScienceDirect, Cochrane Library, Web of Science, CNKI, and Wanfang databases was conducted up to December 2025. Randomized controlled trials and prospective cohort studies involving T2DM patients with AMI were included. Primary laboratory endpoints were circulating inflammatory biomarkers (interleukin-6 [IL-6], high-sensitivity C-reactive protein [hs-CRP], tumor necrosis factor-a [TNF-a]). Secondary outcomes included left ventricular ejection fraction (LVEF) and major adverse cardiovascular events (MACE).</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1207-1221"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of serum 25-hydroxyvitamin D, MIS, and insulin-like growth factor 1 for polycystic ovary syndrome (PCOS).","authors":"Shaomeng Sun, Jianrui Zheng, Ziying Xie","doi":"10.5937/jomb0-62488","DOIUrl":"10.5937/jomb0-62488","url":null,"abstract":"<p><strong>Background: </strong>To investigate blood levels and the importance of Müllerian Inhibiting Substance (MIS), insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3), and 25-hydroxyvitamin D S25(OH)DC in patients with polycystic ovarian syndrome (PCOS).</p><p><strong>Methods: </strong>The observation group consisted of 212 PCOS patients who received treatment at this institution between May 2022 and May 2024, while the control group consisted of 212 healthy women who were physically examined at the same hospital during the same time frame. The two groups' general information, serum 25(OH)D, MIS, IGF-1, and IGFBP-3 levels, and sex hormones and glucose metabolism markers were compared. PCOS patients were divided into the IR group and the non-IR group based on the presence of insulin resistance (IR). The levels of serum 25(OH)D, MIS, IGF-1, and IGFBP-3 were compared between the two groups. The study examined the associations among the four markers and the homeostasis model of insulin resistance index (HOMA-IR), as well as their supplementary diagnostic utility for PCOS.</p><p><strong>Results: </strong>The level of 25(OH)D in the observation group was lower than that in the control group (P&lt; 0.05). Total testosterone (TT), luteinising hormone (LH), estradiol (E2), fasting insulin (FINS), fasting blood glucose (FBG), serum MIS, IGF-1, IGFBP-3, HOMA-IR, and the average body mass index were all greater in the observation group than in the control group (P&lt; 0.05). The IR group's 25(OH)D level was lower than the non-IR group's (P&lt; 0.05). Serum MIS, IGF-1, and IGFBP-3 levels were higher in the IR group than in the non-IR group (P&lt; 0.05). The levels of serum MIS, IGF-1 and IGFBP-3 in the observation group were positively correlated with HOMA-IR (r= 0.659, 0.586, 0.565, P&lt; 0.05), and 25(OH)D was negatively correlated with HOMA-IR (r=-0.548, P&lt; 0.05). The combined auxiliary diagnosis of PCOS by serum 25(OH)D, MIS, IGF-1, and IGFBP-3 had an area under the curve of 0.963, according to the results of receiver operating characteristic curve analysis, which was greater than that of the single detection of each index (0.819, 0.864, 0.814, 0.799).</p><p><strong>Conclusions: </strong>MIS, IGF-1, IGFBP-3, and serum 25(OH)D levels are associated with the development and occurrence of PCOS. The combined detection of these four indicators has high auxiliary diagnostic value for PCOS and is conducive to clinical prevention and treatment.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1412-1419"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of Serum FGLP1, UACR and the risk of heart failure in patients with type 2 diabetes.","authors":"Lianheng Xia, Yingshuo Guo, Jiaxin Wang, Tingxuan Wang, Chunhui Xu, Meiyu Song, Chang Du, Qingjie Wang, Jie Gao","doi":"10.5937/jomb0-65295","DOIUrl":"10.5937/jomb0-65295","url":null,"abstract":"<p><strong>Background: </strong>To explore the correlations between serum FGLP1 (Fibrinogen-like protein 1 C-terminal peptide) levels, the urine albumin-to-creatinine ratio (UACR) and left ventricular diastolic dysfunction (LVDD) in elderly patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>From August 2023 to August 2025, 256 elderly patients with T2DM who were admitted to our hospital were selected as the case group, and 120 healthy individuals who underwent physical examinations were selected as the control group. In accordance with the diagnostic criteria for LVDD, T2DM patients were divided into a disorder group (n=70) and a nondisorder group (n = 186). Single-factor analysis, multivariate logistic regression, and Spearman correlation analyses were performed to examine the relationships among serum FGLP1 levels, UACRs, and LVDD in T2DM patients, and receiver operating characteristic curves were used to evaluate the ability of serum FGLP1 levels and urine UACRs to predict LVDD.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1323-1331"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of serum SIRT4, CTRP5, and galectin-3 levels with the prognosis of diabetic retinopathy patients.","authors":"Wenming Cheng, Hua Lu, Song Ting, Wei Liu","doi":"10.5937/jomb0-61802","DOIUrl":"https://doi.org/10.5937/jomb0-61802","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;To explore the relationships between serum silencing information regulator 4 (SIRT4), complement C1q tumour necrosis factor-related protein 5 (CTRP5), galectin-3 and glycolipid metabolism and prognosis in patients with diabetic retinopathy (DR).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The DR group was selected from among 115 hospitalised DR patients admitted between January 2023 and January 2024, including 61 non-proliferative DR patients (Non-proliferative DR group) and 54 proliferative DR patients (Proliferative DR group). Additionally, 50 subjects who underwent health check-ups in the hospital during the same period were selected as the control group. Indicators of SIRT4, CTRP5, galectin-3, blood glucose [Fasting plasma glucose (FPG)], and the levels of blood lipids in the DR group and the control group were measured and compared. Triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and total cholesterol (TC) were among them. Moreover, the correlations between serum SIRT4, CTRP5, and galectin-3 levels and blood glucose and lipid indicators in DR patients were analysed. The DR patients were monitored and followed up with for six months after treatment. Depending on their level of visual impairment, the patients were split into groups with excellent and poor prognoses. The levels of serum SIRT4, CTRP5 and galectin-3 in the two groups were compared. Multivariate logistic regression was used to analyse the risk factors for poor prognosis in DR patients. A receiver operating characteristic (ROC) curve was used to analyse the predictive value of single or combined detection of SIRT4, CTRP5, and galectin-3 for poor prognosis in patients with DR.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Pearson correlation analysis revealed that the levels of SIRT4, CTRP5, and galectin-3 in DR patients were positively correlated with FPG, TG, TC, and LDL-C (P&lt; 0.05) and negatively correlated with HDL-C (P&lt; 0.05). The poor-prognosis group had higher serum levels of SIRT4, CTRP5, and galectin-3 than the good-prognosis group (P&lt; 0.05). The poor prognosis group's DR course was longer than the excellent prognosis group's (P&lt; 0.05), and the proportion of proliferative DR was greater than that in the good prognosis group (P&lt; 0.05). DR course S6 months, SIRT4 S24 ng/mL, CTRP5 S8 ng/mL, galectin-3&gt; 1,400 ng/mL, and DR stage of the proliferative type were all independent risk factors for poor prognosis in DR patients. The ROC curve analysis showed that the AUCs of each index for predicting a poor prognosis in DR patients were 0.796, 0.743, and 0.718, respectively, when the ideal cutoff values for the individual detection of serum SIRT4, CTRP5, and galectin-3 were 24 ng/mL, 8 ng/mL, and 400 pg/mL, respectively. Based on the results of the multivariate logistic regression analysis, a model with Ln(P/1-P) = 0.573 X X SIRT4 + 0.809 xX CTRP5 + 0.424xX Galectin-3 was established for the combine","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1373-1382"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between vagus nerve cross-sectional area measured by ultrasound and inflammatory biomarkers in hospitalised patients with COVID-19.","authors":"Olivera Jovanikić, Goran Stevanović, Ivan Leković, Snježana Vukotić, Nemanja Rančić, Milan Jovanović","doi":"10.5937/jomb0-57970","DOIUrl":"https://doi.org/10.5937/jomb0-57970","url":null,"abstract":"<p><strong>Background: </strong>The vagus nerve plays an important role in neuroimmune communication. This study aimed to examine whether systemic inflammatory biomarkers are associated with ultrasound-measured cross-sectional area (CSA) of the vagus nerve in hospitalised patients with COVID-19.</p><p><strong>Methods: </strong>In this cross-sectional study, 68 hospitalised adults with PCR-confirmed SARS-CoV-2 infection underwent bilateral ultrasound assessment of vagus nerve CSA. For each nerve, CSA was calculated as the mean of three measurements. Serum levels of C-reactive protein (CRP), fibrinogen, and ferritin were recorded. CSA values and inflammatory biomarkers were classified as within or outside predefined reference ranges. Binary logistic regression was used to assess associations between inflammatory biomarkers and vagus nerve CSA classified as outside the reference range. Receiver operating characteristic (ROC) analysis was performed. As a secondary exploratory analysis, a multilayer perceptron neural network was constructed to evaluate whether the same biomarkers could classify vagus nerve CSA as within or outside the reference range.</p><p><strong>Results: </strong>Mean vagus nerve CSA was 1.32±0.30 mm2 on the right side and 1.20±0.28 mm2 on the left side. Inflammatory biomarkers were significantly associated with right vagus nerve CSA classified as outside the reference range in logistic regression, whereas no significant association was observed for the left vagus nerve. The regression model showed acceptable discriminative performance for the right vagus nerve (AUC=0.76, p=0.018). The exploratory neural network model showed similar classification performance.</p><p><strong>Conclusions: </strong>Systemic inflammatory biomarkers were associated with right vagus nerve CSA classified as outside the reference range on ultrasound, but not with left vagus nerve CSA, in hospitalised patients with COVID-19. These findings suggest a possible link between systemic inflammation and ultrasound-detectable variation in vagus nerve morphology. Larger studies are needed to confirm these findings and clarify their biological significance.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1251-1258"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrinogen-to-albumin ratio links systemic inflammation to osteoporotic fractures and shows discriminative performance together with PLR, NLR, and MLR.","authors":"Youxin Fu, Daigui Cao, Zeyu Liu, Zhiwei Liu, Jianping Guo, Xu Zhou, Jie Hao","doi":"10.5937/jomb0-64875","DOIUrl":"10.5937/jomb0-64875","url":null,"abstract":"<p><strong>Background: </strong>Osteoporotic fracture (OPF) remains a major cause of disability in older adults. Laboratory-available composite indices integrating coagulation, inflammation, and nutritional status may facilitate risk stratification in patients with osteoporosis. To investigate the relationship between the fibrinogen-to-albumin ratio (FAR) and systemic inflammatory indices (platelet-to-lymphocyte ratio [PLR], neutrophil-to-lymphocyte ratio [NLR], and monocyte-to-lymphocyte ratio [MLR]) in osteoporosis, and to evaluate their discriminative value for identifying concurrent osteoporotic fractures.</p><p><strong>Methods: </strong>This retrospective study included 98 patients with osteoporosis admitted between January 2024 and May 2025, categorized into a fracture group (n=39) and a non-fracture group (n = 59). FAR, PLR, NLR, and MLR were calculated from routine laboratory tests obtained within 24 h of admission. Group differences were assessed, Pearson correlation was used to examine associations between FAR and inflammatory indices, and logistic regression was performed to identify independent clinical/imaging correlates of fracture. Receiver operating characteristic (ROC) curves were constructed to evaluate discriminative performance.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"45 6","pages":"1269-1275"},"PeriodicalIF":1.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}