Journal of Medical Biochemistry最新文献

{"title":"The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage.","authors":"Tingting Zhao, Ye Liu, Haoran Jia, Dexing Wang, Meng Du, Weiwei Wang","doi":"10.5937/jomb0-51197","DOIUrl":"10.5937/jomb0-51197","url":null,"abstract":"<p><strong>Background: </strong>The paper aimed to explore the significance of serum soluble ST2 (sST2) and circulating cell-free DNA (cfDNA) in predicting cardiac functions in children with severe pneumonia complicated by myocardial damage.</p><p><strong>Methods: </strong>This case series study evaluated the serum sST2 and cfDNA levels of 60 children with severe pneumonia complicated by myocardial damage, assessing clinical data, biomarker levels, and cardiac function.</p><p><strong>Results: </strong>We analyzed data from a cohort of 60 patients with a mean age of 4.47±1.88 years and a male: female ratio of 28:32. At baseline, patients had elevated levels of serum biomarkers, including sST2 and cfDNA, which were associated with cardiac function parameters and clinical outcomes. After 6 months, patients showed significant correlations between sST2, cfDNA, and cardiac function parameters, including left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVESd), and E/A ratio. Multivariate analysis revealed that higher levels of sST2 and cfDNA were associated with increased LVEDd, LVESd, and E/A ratio, as well as a lower likelihood of improvement and a higher likelihood of 6-month readmission.</p><p><strong>Conclusions: </strong>These findings suggest that sST2 and cfDNA may be useful biomarkers for predicting cardiac function and outcomes in this patient population.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"264-268"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of use of metformin or combination of metformin and pioglitazone on oxidative stress in type 2 diabetes mellitus.","authors":"Temiz Gençoğlu Ayşe Tuğçenur, Kalkan Emra Asfuroğlu, Oğuzhan Zengin, Özcan Erel, İhsan Ateş","doi":"10.5937/jomb0-50062","DOIUrl":"10.5937/jomb0-50062","url":null,"abstract":"<p><strong>Background: </strong>We aimed to examine how oxidative stress changes after treatment and its relationship with metabolic parameters in patients diagnosed with Type 2 Diabetes Mellitus treated with metformin alone or with a combination of metformin and pioglitazone.</p><p><strong>Methods: </strong>The study population consisted of a total of 60 patients, including the group diagnosed with Type 2 Diabetes Mellitus (T2DM) who received metformin 2x1000 mg (n=30) and the other group who received metformin with pioglitazone 2x15/1000 mg (n=30). Serum IMA (ischemia-modified albumin), TAS (total antioxidant status), TOS (total oxidant status) and thiol-disulphide homeostasis were measured before and after 12 weeks of treatment.</p><p><strong>Results: </strong>No significant change was detected in Native sulfhydryl (SH) and Total SH levels in both Metformin and combination groups. IMA levels increased significantly in both drug groups (p=0.03 and p=0.01, respectively). Although the TAS level increased in both groups, no significant change was detected. While the TOS and oxidative stress index (OSI) index decreased significantly in the combination group (p<0.001), the decrease in the metformin group was not significant. No significant difference was detected between Native SH, Total SH, Disulfide, IMA, TAS, TOS levels and OSI index changes of both drug groups.</p><p><strong>Conclusions: </strong>We found that the use of anti-diabetic drugs did not have a significant effect on oxidative stress.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"347-354"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic values of noradrenaline administered dose, procalcitonin (PCT) and blood lactic acid for septic shock.","authors":"Lili Ding, Mengru Liu, Haijun Sun","doi":"10.5937/jomb0-53853","DOIUrl":"10.5937/jomb0-53853","url":null,"abstract":"<p><strong>Background: </strong>Sepsis/septic shock is a life-threatening condition that requires prompt and effective treatment. Noradrenaline is a widely used vasopressor to manage septic shock, but its optimal dosage remains unclear. This study aimed to investigate the effects of noradrenaline doses on the prognosis of patients with sepsis/septic shock and identify the influencing factors for patient survival.</p><p><strong>Methods: </strong>A retrospective study was conducted on 126 patients with sepsis/septic shock who received noradrenaline treatment in the intensive care unit (ICU). Patients were divided into survival (n=91) and death (n=35) groups. Clinical data, laboratory results, and noradrenaline doses were collected and compared between the two groups.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"319-329"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of significance of CARD11 and MYO1G expressions in pulmonary tuberculosis and their predictive value for prognosis of recurrence.","authors":"Fengxia Liu, Shengxun Lin, Li Li, Bei Xu, Tingting Chang","doi":"10.5937/jomb0-54554","DOIUrl":"10.5937/jomb0-54554","url":null,"abstract":"<p><p>Pulmonary tuberculosis (PTB) is one of the most common infectious diseases worldwide, with extremely high morbidity and mortality. An in-depth understanding of the molecular pathogenesis of PTB is crucial for finding novel diagnostic and therapeutic approaches in the future. In this study, we identified 52 differentially expressed genes (DEGs) from the GSE34608 dataset in the Gene Expression Omnibus (GEO) database, and the protein-protein interaction (PPI) network showed that these DEGs included 42 nodes and 20 edges. We found that CARD11 and MYO1G were closely associated with T cell activation by functional enrichment analysis. Upon further clinical case analysis, we found that the expressions of CARD11 and MYO1G in the peripheral blood of patients with PTB were lower than those of healthy individuals. Meanwhile, through Receiver operating characteristic (ROC) curve analysis, we found that CARD11 and MYO1G showed excellent diagnostic effects on the occurrence and prognosis of PTB recurrence. Thus, CARD11 and MYO1G are promising indicators for assessing PTB in the future.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"355-363"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of plasma folate, homocysteine and erythrocyte folate levels in pregnant women after folic acid administration during different pregnancies.","authors":"Xinglin Jin, Mei Meng, Xi Wang","doi":"10.5937/jomb0-52621","DOIUrl":"10.5937/jomb0-52621","url":null,"abstract":"<p><strong>Background: </strong>To examine and evaluate the alterations in plasma folate, homocysteine (HCY), and erythrocyte folate (FOA) concentrations among expectant mothers following folic acid supplementation in distinct pregnancies.</p><p><strong>Methods: </strong>A retrospective analysis was conducted with 416 pregnant women, divided into two groups: an observation group (n=210) who consistently took folic acid throughout pregnancy, and a control group (n=206) who only supplemented during early pregnancy. Key outcomes included plasma folate, HCY, and FOA levels, as well as pregnancy complications and neonatal outcomes.</p><p><strong>Results: </strong>Plasma folate levels were significantly higher in the observation group (10.42±2.96 ng/mL) compared to the control group (7.51±1.58 ng/mL, P<0.001). HCY levels were lower in the observation group (6.54±1.51 mmol/L) versus the control group (10.58±1.27 mmol/L, P<0.001). FOA levels were also higher in the observation group (486.42±105.29 ng/mL) compared to the control (430.20±75.12 ng/mL, P<0.001). The observation group had reduced rates of cesarean section (26.19% vs. 36.41%, P=0.025), anemia (3.81% vs. 8.74%, P=0.038), and hypertension during pregnancy (5.24% vs. 11.65%, P=0.018). Pearson correlation analysis showed a positive correlation between plasma folate and FOA (r=0.116, P<0.05) and negative correlations between plasma folate and HCY (r=-0.411, P<0.05) and between FOA and HCY (r=-0.286, P<0.05). The observation group had significantly lower FBG and P2BG levels and a reduced incidence of gestational anemia and HIP compared to the control group (P<0.05). Cesarean sections were also less frequent in the observation group. Newborns in the observation group had significantly greater height, weight, head circumference, and chest circumference than those in the control group (P<0.05).</p><p><strong>Conclusions: </strong>Consistent folic acid supplementation throughout pregnancy significantly improves maternal folate status, decreases pregnancy-related complications, and enhances neonatal health outcomes. These findings underscore the need for continuous folic acid intake during pregnancy, which could inform clinical guidelines and public health policies to optimize maternal and neonatal health.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"295-302"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of Denosumab and Zoledronic acid effects on bone metabolism and bone mineral density in individuals with osteoporotic vertebral compression fractures.","authors":"Shouda Gao, Lijun Zhang, Liyan Liu, Jiayin Meng","doi":"10.5937/jomb0-52084","DOIUrl":"10.5937/jomb0-52084","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the efficacy of Denosumab (DEN) versus Zoledronic acid (ZOL) in treating patients with osteoporotic vertebral compression fractures (OVCF) after percutaneous kyphoplasty (PKP).</p><p><strong>Methods: </strong>In this study, 128 OVCF patients who underwent PKP in our hospital from June 2019 to August 2022 were selected and randomized into a DEN group treated with DEN and a ZOL group treated with ZOL. Bone mineral density (BMD), bone metabolism, pain, and lumbar mobility were compared between the two groups before and after treatment, and the anterior vertebral height and local kyphotic angle were measured. Finally, the one-year refracture rate and treatment cost were counted.</p><p><strong>Results: </strong>The two groups showed no notable difference in pain, lumbar mobility, anterior vertebral height, and local kyphotic angle after treatment (P>0.050). BMD was higher in the DEN group at 6 and 12 months after treatment, while b isomer of C-terminal telopeptide of type I collagen (b-CTX) was lower (P<0.050). No statistical inter-group difference was identified in the one-year re-fracture rate (P>0.050), while the total treatment cost was lower in the DEN group compared with ZOL group (P<0.050).</p><p><strong>Conclusions: </strong>DEN and ZOL effectively improve the prognosis of OVCF patients after PKP, but DEN can more significantly improve BMD and bone metabolism with higher economic benefits.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"269-276"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption value of serum hematological inflammatory markers in early diagnosis of necrotising enterocolitis.","authors":"Ruogu Luo, Jing Zhang, Xiaolong Li, Fei Peng, Anpeng Zhang, Pengfei Zhang","doi":"10.5937/jomb2502244L","DOIUrl":"10.5937/jomb2502244L","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and intervention of neonatal necrotising enterocolitis (NEC) are crucial for improving prognosis. It was to assess the diagnostic and staging value of high-sensitivity C-reactive protein (hs-CRP), white blood cell count (WBC), and interleukin (IL)-6 levels in NEC, and to explore their correlation with disease severity.</p><p><strong>Methods: </strong>This retrospective study analysed clinical data from 43 NEC patients in the neonatology department of Northwest Women and Children's Hospital, designated as the experimental group (EG), and concurrently selected 38 healthy newborns as the control group (CG). Serum hsCRP, WBC, and IL-6 were measured in both groups. Statistical analyses were performed using SPSS 27.0.</p><p><strong>Results: </strong>hs-CRP, WBC, and IL-6 in NEC patients greatly surpassed those in healthy newborns, and these markers were notably positively correlated with NEC staging (r=0.756, 0.234, 0.901, P<0.05). Combined detection of hs-CRP, WBC, and IL-6 in early NEC diagnosis yielded an AUC of 0.988, with a sensitivity of 93.02% and specificity of 97.37%, all superior to individual detections (P<0.05).</p><p><strong>Conclusions: </strong>hs-CRP, WBC, and IL-6 are essential in diagnosing and assessing NEC, particularly combined detection, which greatly improves early diagnostic accuracy. Future research should further investigate additional inflammatory markers to optimise diagnostic methods, providing a more comprehensive scientific basis for early clinical intervention and treatment.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"244-249"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of gene polymorphisms of angiotensin-converting enzyme 2 with onset and prognosis of hypertrophic cardiomyopathy.","authors":"Sujuan Li, Xizhi Lin, Haoting Ye, Biyun Li, Siyu Zeng, Qinghua Mei, Yukai Huang, Yixuan Liu","doi":"10.5937/jomb0-54585","DOIUrl":"10.5937/jomb0-54585","url":null,"abstract":"<p><strong>Background: </strong>To investigate the correlations of the gene polymorphisms of angiotensin-converting enzyme 2 (ACE2) with the onset and prognosis of hypertrophic cardiomyopathy (HCM), so as to provide references for the early prevention and precise treatment of HCM in the future.</p><p><strong>Methods: </strong>In this case-control study, a total of 100 HCM patients (HCM group) and 100 healthy people receiving physical examination who had matched age, gender and race (Control group) were collected. The single nucleotide polymorphisms (rs102312, rs102883 and rs119247) in the promoter region of ACE2 gene were genotyped by means of conformation-difference gel electrophoresis. Whether the distribution frequency of ACE2 genotypes is in agreement with the law of genetic equilibrium was examined using chi-square test. Meanwhile, the correlations of different polymorphisms and alleles in the promoter region of ACE2 gene with the onset and prognosis of HCM were analyzed.</p><p><strong>Results: </strong>The Hardy-Weinberg equilibrium analysis showed that all the three polymorphisms of ACE2 gene were in agreement with the law of genetic equilibrium (p>0.05). According to the results of genetic association analysis, the polymorphism rs102312 and its alleles in the promoter region of ACE2 gene were correlated with the occurrence of HCM (p<0.05), while the polymorphisms rs102883 and rs119247 as well as their alleles had no associations with the occurrence of HCM (p>0.05). Furthermore, it was found that the cardiac function and prognosis of HCM patients carrying genotype GG of polymorphism rs102312 were poorer than those of patients carrying genotype TT (p<0.05).</p><p><strong>Conclusions: </strong>The polymorphism rs102312 in the promoter region of ACE2 gene is associated with the onset of HCM in patients, and HCM patients carrying the genotype GG of polymorphism rs102312 have a poorer clinical prognosis.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"303-311"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings.","authors":"Mihailo Stjepanovic, Zorica Sumarac, Drazenka Grubac, Slobodan Belic, Nikola Maric, Natasa Djurdjevic, Aleksandar Sumarac, Jelena Jankovic, Snezana Jovicic","doi":"10.5937/jomb0-50994","DOIUrl":"10.5937/jomb0-50994","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis is a granulomatous disease which can afflict virtually any tissue in the human body, most commonly the mediastinal lymph nodes and lungs. Pathohistological confirmation is the gold standard in establishing a diagnosis; however, determining the activity of the disease requires multiple clinical, radiographic and laboratory procedures. PET/CT scan is considered the gold standard for determining the presence of active granuloma but has several significant limitations (radioactive material, cost, overall access to device). ACE and chitotriosidase are biomarkers used for diagnosing sarcoidosis and could have a place in determining the activity of the disease when compared with the results of PET/CT scans.</p><p><strong>Methods: </strong>We have compared the levels of ACE and chitotriosidase with the levels of SUVmax values in patients with sarcoidosis.</p><p><strong>Results: </strong>SUVmax and chitotriosidase levels were significantly correlated at the baseline and after the follow-up period, regardless of gender, age, duration of disease and radiography stage, while SUVmax and ACE levels were not. Chitotriosidase also showed a significant predictive ability to decrease the activity of sarcoidosis, which represented the decrease of SUVmax as the effect of therapy compared with ACE.</p><p><strong>Conclusions: </strong>In the absence of an ideal biomarker for sarcoidosis (high sensitivity, specificity and stability), chitotriosidase can be used in determining the activity of the disease, as it has shown a significant correlation to the gold standard-PET/CT scan.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"287-293"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), matrix metallopeptidase-2/9 (MMP-2/9), and T-lymphocyte subsets in patients undergoing thoracoscopic surgery under refined management for non-small-cell lung cancer.","authors":"Shuxin Cai, Yannan Zhang","doi":"10.5937/jomb0-51316","DOIUrl":"10.5937/jomb0-51316","url":null,"abstract":"<p><strong>Background: </strong>Non-small-cell lung cancer (NSCLC) remains one of the most common malignancies worldwide, posing a great potential threat to the health and life safety of patients.</p><p><strong>Methods: </strong>One hundred and fifty NSCLC patients admitted to our hospital from September 2022 to September 2023 were selected whose inflammatory response and changes in T-lymphocyte subpopulations before and after surgery were detected, and patients' psychological status was investigated. Finally, patients were followed up for 6 months to record the prognostic survival rate.</p><p><strong>Results: </strong>Postoperative inflammatory factors and CD8 + were lower in the research group than in the control group, while CD3 + , CD4 + and CD4 + /CD8 + were higher than in the control group (P<0.05). Meanwhile, the psychological status of the research group was better. However, the two groups did not differ in prognostic survival (P>0.05).</p><p><strong>Conclusions: </strong>Perioperative refinement of care can optimize the surgical process in patients with NSCLC, and the cellular immune function was enhanced.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 2","pages":"277-286"},"PeriodicalIF":2.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}