Journal of Medical Biochemistry最新文献

{"title":"Serum biomarkers in oral lichen planus: A biochemical perspective.","authors":"Jiawei Zhang, Jie Yang, Wei Lu, Shasha Zang, Chengbi Tong","doi":"10.5937/jomb0-57322","DOIUrl":"10.5937/jomb0-57322","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucosal tissues of the oral cavity. Its pathogenesis involves immune dysregulation, angiogenesis, and psychological stress. Identifying reliable biomarkers can enhance diagnosis, monitor disease progression, and guide personalised treatment strategies. This study aimed to investigate five key serum biomarkers in OLP patients, including angiopoietin-2 (Ang-2), vitamin D, IgA, IgG, and cortisol, to explore their associations with disease severity.</p><p><strong>Methods: </strong>This observational, case-control study enrolled 100 OLP patients and 80 healthy controls. The OLP patients were classified into three subtypes: reticular (n=30), atrophic (n=35), and erosive (n=35). Fasting blood samples were collected, and serum levels of Ang-2, vitamin D, IgA, IgG, and cortisol were measured using ELISA, HPLC, immunoturbidimetry, and chemiluminescent immunoassays. Statistical analyses, including t-tests, ANOVA, and Pearson correlation, were performed to assess biomarker levels and their correlations with disease severity.</p><p><strong>Results: </strong>Ang-2, IgA, and IgG levels were significantly elevated in OLP patients, particularly in the erosive subtype (P<0.001), with positive correlations between these markers and disease severity. Vitamin D and cortisol levels were significantly reduced in OLP patients compared to controls (P<0.01) and showed negative correlations with disease severity. These findings indicate the role of vascular, immune, metabolic, and stress-related factors in OLP pathogenesis.</p><p><strong>Conclusions: </strong>Ang-2, vitamin D, IgA, IgG, and cortisol are valuable biomarkers for assessing OLP severity and guiding personalised treatment. Monitoring these biomarkers can aid in diagnosing OLP, tracking disease progression, and optimising therapeutic strategies.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1263-1270"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptosis in prostate carcinoma tissue: The role of caspase-3, caspase-1, and alkaline DNase activity.","authors":"Andrej Veljkovic, Jovan Hadzi-Djokic, Gordana Kocic, Xiaobo Li, Stefanos Roumeliotis, Dušan Sokolović, Aleksandra Klisic","doi":"10.5937/jomb0-57574","DOIUrl":"10.5937/jomb0-57574","url":null,"abstract":"<p><strong>Background: </strong>Prostate glandular tissue maintains a delicate balance between cellular proliferation and programmed cell death (apoptosis), ensuring the preservation of normal glandular architecture in healthy individuals. Disruption of this equilibrium - whether due to excessive proliferation or impaired apoptotic mechanisms - can contribute to the initiation and progression of prostate cancer. The objective of this study was to evaluate the expression and activity of caspase-3, caspase-1, and alkaline deoxyribonuclease (DNase) in prostate cancer tissue and tumour-adjacent tissue in comparison to clinically healthy prostate tissue. The aim was to determine whether alterations in these parameters could serve as early biomarkers for the transformation of surrounding tissue into a precancerous phenotype.</p><p><strong>Methods: </strong>The concentration of caspase-3 and caspase-1, as well as the activity of alkaline DNase, were examined in prostate tissue samples, including cancerous tissue, adjacent tissue near the tumour, and surrounding healthy tissue.</p><p><strong>Results: </strong>The results revealed a significant reduction in caspase-3 levels in cancerous tissue (p<0.05), with an even more pronounced decrease in the adjacent peritumoural tissue (p<0.05). In contrast, caspase-1 levels were markedly elevated in both cancerous tissue (p<0.00001) and the surrounding non-malignant peritumoural tissue (p<0.0005). Similarly, alkaline DNase activity (both total and specific) was significantly increased in cancerous tissue (p<0.00001), with a moderate but statistically significant elevation in the tumour-adjacent tissue (p<0.000017) compared to control tissue.</p><p><strong>Conclusions: </strong>These findings suggest a disruption in the interplay between caspase-3 and alkaline DNase, potentially as a consequence of necrotic processes or enzyme release from inhibitory complexes. Furthermore, the increased expression of caspase-1 implies that inflammatory responses may play a role in tumourigenesis.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1297-1304"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D status among pregnant women of North Macedonia: Assessing deficiency rates and associated risks factors.","authors":"Boshku Aleksandra Atanasova, Vasko Aleksovski, Krstevska Slagana Simeonova, Nikolovska Elena Gjorgievska, Igor Samardjiski, Markova Ana Daneva","doi":"10.5937/jomb0-55601","DOIUrl":"10.5937/jomb0-55601","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D is an essential vitamin that plays a key role in maintaining overall health. During pregnancy, the demand for vitamin D increases to support the growing needs of the fetus. Vitamin D deficiency is highly prevalent in pregnant women worldwide. Our study aimed to evaluate the vitamin D deficiency rate among pregnant women in the Republic of North Macedonia, along with influencing factors.</p><p><strong>Methods: </strong>We conducted a prospective study of randomly selected pregnant women with different body mass indexes among vitamin supplementation users and non-users in two different seasons.</p><p><strong>Results: </strong>A total of 309 pregnant women aged > 18 years were recruited from June 2022 to April 2023, with an average vitamin D concentration of 38.9 (36.6-40.2) nmol/L. During winter, 80.8 % of pregnant women had vitamin D deficiency.</p><p><strong>Conclusions: </strong>Even though more than 77.3 % of pregnant women consume multivitamins containing vitamin D, vitamin D deficiency is highly prevalent among pregnant women, especially among obese pregnant women and during the winter months.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1183-1190"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognosis of primary aldosteronism achieved incomplete surgical remission and changes in plasma aldosterone, plasma renin activity, and biochemical indicators.","authors":"Zihao Guo, Jing Wang, Xiang Ren, Xing Li, Yisheng Yin, Yiqun Tian, Zhenliang Qin, Kun Yuan, Xiaoyong Zeng","doi":"10.5937/jomb0-54960","DOIUrl":"10.5937/jomb0-54960","url":null,"abstract":"<p><strong>Background: </strong>Some primary aldosteronism (PA) patients with spontaneous hypokalemia achieved incomplete remission after surgical treatment. In this study, we aimed to construct a nomogram to predict surgical benefits for primary aldosteronism (PA) patients with typical symptoms, incorporating changes in plasma aldosterone, plasma renin activity (PRA), and aldosterone/renin ratio (ARR) to help clinicians assess prognosis and develop optimised treatment plans.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled 162 patients between January 2017 and January 2024. Baseline characteristics, clinical indicators, and biochemical results, including plasma aldosterone, PRA, ARR, and serum potassium, were compared among patients with different clinical and biochemical outcomes. A nomogram was developed and internally validated with risk factors selected from univariate and multivariate logistic regression analyses.</p><p><strong>Results: </strong>Complete clinical and biochemical success was achieved in 69 (42.6%) and 129 (79.6%). Five risk factors were used to develop a nomogram. The area under the receiver operating characteristic curve (AUC) was 0.856 (0.788-0.924) in the training dataset and 0.726 (0.580-0.872) in the validation dataset. The calibration curve showed good agreement, and the decision curve analysis demonstrated the clinical utility of this model.</p><p><strong>Conclusions: </strong>PA patients with older age, higher systolic blood pressure, lower plasma aldosterone, more than 5 years of hypertension, and an adrenal gland mass on the left side or both sides had more probability of achieving incomplete remission after the surgery.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1227-1240"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of treating NELL1-positive idiopathic membranous nephropathy on clinical outcomes, serum cytokine levels (IL-6, IL-10, IL-2, IL-17), nutritional status, and immune responses.","authors":"Xiaojing Liu, Yanqiu Yu, Kang Li","doi":"10.5937/jomb0-56892","DOIUrl":"10.5937/jomb0-56892","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the therapeutic effects of glucocorticoids (GCs) combined with tacrolimus (TAC) in the treatment of Neural Epidermal Growth Factor-Like 1 (NELL1)-positive idiopathic membranous nephropathy (IMN), with a focus on clinical outcomes, nutritional status, and inflammatory response.</p><p><strong>Methods: </strong>A total of 84 NELL1-positive IMN patients from Cangzhou Central Hospital (January 2020-February 2024) were randomly assigned to a research group (GCs+TAC) and a control group (GCs alone). The research group received methylprednisolone (0.5 g), prednisone (0.5 mg/kg), and tacrolimus (0.05 mg/kg/day), while the control group was treated with methylprednisolone and prednisone alone. Clinical parameters, including renal function, blood glucose, lipids, nutritional proteins, and cytokine levels (IL-6, IL-10, IL-2, IL-17), were measured at baseline and after six months of treatment. Nutritional status was assessed using the Nutritional Risk Screening 2002 (NRS 2002).</p><p><strong>Results: </strong>The two groups had no significant differences in clinical efficacy or adverse reactions. However, the research group exhibited significant improvements in renal function, glycemic control, lipid profile, and nutritional status (P<0.05). Furthermore, the research group showed a more favourable cytokine profile, with more significant reductions in pro-inflammatory cytokines (IL-6, IL-17) and increases in anti-inflammatory cytokines (IL-10, IL-2) compared to the control group (P<0.05). Both groups had comparable safety profiles, with no significant increase in adverse events.</p><p><strong>Conclusions: </strong>Combining GCs and TAC is an effective and safe therapeutic option for NELL1-positive IMN. It improves clinical outcomes, maintains nutritional stability, and modulates immune responses without increasing adverse reactions.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1201-1209"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of prostate cancer antigen 3 (PCA3), sarcosine, glypican-1 (GPC1), urokinase plasminogen activator receptor (uPAR), and thymidine kinase 1 (TK1), and T2WI and DWI radiomics model for distinguishing benign prostatic hyperplasia, prostate cancer, and prostatitis.","authors":"Fan Yang, Wei Guo, Siqin Sun, Yanan Huang","doi":"10.5937/jomb0-57639","DOIUrl":"10.5937/jomb0-57639","url":null,"abstract":"<p><strong>Background: </strong>To measure the diagnostic value of T2WI and DWI radiomics model, combined with advanced biomarkers, in distinguishing benign prostatic hyperplasia (BPH), prostate cancer (PCa) and prostatitis.</p><p><strong>Methods: </strong>A total of 90 patients with prostate diseases were selected from our hospital from January 2022 to January 2024. All patients underwent T2WI and DWI MRI examinations. Regions of interest (ROI) were delineated, and imaging features were extracted using radiomics analysis. In addition, novel biomarkers, including Prostate Cancer Antigen 3 (PCA3), Sarcosine, Glypican-1 (GPC1), Urokinase Plasminogen Activator Receptor (uPAR), and Thymidine Kinase 1 (TK1), were analysed for their diagnostic significance. Feature selection was performed using LASSO regression, and a random forest model was established for classification. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of the T2WI and DWI radiomics model with and without biomarker integration.</p><p><strong>Results: </strong>Among the 90 patients with prostate diseases, 50 cases were PCa, 20 cases of prostatitis and 20 cases of BPH were detected by biopsy. The PI-RADS v2 score in the PCa group presented elevation relative to those in the BPH and prostatitis groups (P<0.01). The ADC values in the PCa group were reduced relative to those in the BPH and prostatitis groups (P<0.01). The integration of biomarkers with radiomics analysis led to improved diagnostic performance. The AUC value, sensitivity, and specificity of the T2WI and DWI radiomics model were higher relative to those of PI-RADS V2.</p><p><strong>Conclusions: </strong>The T2WI and DWI radiomics model, when combined with novel biomarkers, enhances the accuracy of distinguishing PCa, BPH, and prostatitis. This approach may provide an advanced diagnostic tool for personalised prostate disease management.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1376-1385"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of the correlation between IL-8, IL-10 and nutritional proteins in patients with sleep disorders in chronic obstructive pulmonary disease.","authors":"Mei Liang, Mei Zhou, Xiaofeng Fu, Qianyun Zhou, Liang Li","doi":"10.5937/jomb0-54163","DOIUrl":"10.5937/jomb0-54163","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases worldwide, with an increasing incidence in recent years. In this study, we analysed the relationship between interleukin-8 (IL-8), interleukin-10 and COPD to provide a reference for clinical diagnosis and treatment in the future.</p><p><strong>Methods: </strong>A randomised controlled trial was conducted on 56 COPD patients and 56 concurrent healthy volunteers who visited our hospital from March 2022 to December 2022. Among them, COPD patients served as the research group, and healthy volunteers served as the control group. To compare the IL-8 and IL-10 of the two groups and to analyse the relationship between IL-8, IL-10 and lung function, nutrient proteins, clinical efficacy and prognosis of the research group.</p><p><strong>Results: </strong>IL-8 was higher in the study group than in the control group and was negatively correlated with lung function indices and nutrient proteins (P<0.05). IL-10 in the research group was lower than in the control group, and there was a positive correlation with lung function indexes and nutritional proteins (P<0.05). After treatment, IL-8 was lower, and IL-10 was higher in the research group (P<0.05). In addition, IL-8 and IL-10 in the research group demonstrated excellent assessment of COPD occurrence, sleep disturbance, and prognostic recurrence.</p><p><strong>Conclusions: </strong>IL-8 and IL-10 not only directly participate in the occurrence of COPD by affecting the human immune microcirculation but also accelerate the progression of COPD by causing malnutrition.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1191-1200"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma D-dimer and prothrombin fragment 1+2 in evaluating the occurrence of venous thromboembolism in advanced cancer patients and the effect of preventive anticoagulant therapy.","authors":"Yongliang Huang, Yongchun Xu, Chuanqing Ke, Baiping Zhang, Ying Zhong, Huiying Fu","doi":"10.5937/jomb0-55897","DOIUrl":"10.5937/jomb0-55897","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the role of D-dimer (DD) and prothrombin fragment 1+2 (PF1+2) in assessing the risk of venous thromboembolism (VTE) in advanced cancer patients, as well as the impact of preventive anticoagulant therapy.</p><p><strong>Methods: </strong>A total of 137 advanced cancer patients admitted to the 908th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force Hospital between February 2023 and June 2024 were included. Patients were divided into two groups based on the presence (VTE group, n=49) or absence (non-VTE group, n=88) of VTE. Blood tests were performed at admission, and the relationship between DD, PF1+2, and VTE risk was analysed. Patients without VTE were further categorised into two treatment groups: the preventive anticoagulant treatment group (AG, n=48) and the conventional treatment group (RT, n=40), based on their preference. The incidence of VTE in both groups was compared to assess the effectiveness of preventive anticoagulant therapy.</p><p><strong>Results: </strong>Before chemotherapy, DD levels were significantly higher in patients who developed VTE than those who did not. Both DD and PF1+2 were found to be independent risk factors for VTE after chemotherapy. The incidence of VTE was lower in the AG group than in the RT group, with a statistically significant difference.</p><p><strong>Conclusions: </strong>DD and PF1+2 are reliable indicators for assessing VTE risk in advanced cancer patients and can help guide the use of preventive anticoagulant therapy.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1305-1313"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of magnesium sulfate and personalised dietary guidance on hemodynamics and inflammatory cytokines in pregnancy-induced hypertension.","authors":"Miao Shen, Ying Zhuang, Yaning Zheng, Mengqin Wang, Jiexun Wang, Shuoying Lyu","doi":"10.5937/jomb0-57165","DOIUrl":"10.5937/jomb0-57165","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy-induced hypertension (PIH) is a significant cause of maternal and neonatal complications, often linked to vascular dysfunction and inflammatory responses. This study aimed to evaluate the effects of magnesium sulfate (MS) combined with personalised dietary guidance on hemodynamic parameters and inflammatory cytokine profiles in PIH patients.</p><p><strong>Methods: </strong>A total of 108 PIH patients were randomly assigned to two groups: a research group (MS and dietary guidance) and a control group (dietary guidance only). Hemodynamic parameters, including systolic and diastolic blood pressure (SBP, DBP), plasma viscosity (PV), and erythrocyte aggregation index (EI), were measured, along with inflammatory cytokines [Interleukin-6 (IL-6), Interleukin-10 (IL-10), and Interleukin-1b (IL-1b)], before and after treatment.</p><p><strong>Results: </strong>The research group, which received both MS and dietary guidance, showed significant reductions in SBP, DBP, PV, and EI compared to the control group. Additionally, inflammatory cytokines IL-6 and IL-1b were significantly reduced in the research group, indicating an improvement in the inflammatory response. While IL-10 levels decreased in both groups, this change was not statistically significant.</p><p><strong>Conclusions: </strong>Combining magnesium sulfate and personalised dietary guidance effectively improves hemodynamic stability and reduces inflammatory markers in PIH patients.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1219-1226"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum estradiol (E2), progesterone (P), and human chorionic gonadotropin (HCG), D-dimer (D-D) fibrinogen (FIB) levels after low molecular weight heparin sodium on preventing miscarriage in patients with adverse pregnancy and delivery.","authors":"Liucheng Pei, Ting Wang, Qiuling Yang","doi":"10.5937/jomb0-56635","DOIUrl":"10.5937/jomb0-56635","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the effects of subcutaneous injection of low molecular weight heparin (LMWH) sodium on preventing miscarriage in patients with adverse pregnancy and delivery. Specifically, it evaluates changes in serum estradiol (E2), progesterone (P), and human chorionic gonadotropin (HCG), as well as D-dimer (D-D) and fibrinogen (FIB) levels following treatment.</p><p><strong>Methods: </strong>A total of 82 patients with adverse pregnancy admitted to Wuhai Maternal and Child Health Hospital from April to December 2024 were randomly assigned to either the control group (CG, n=41) receiving dydroges-terone therapy or the observation group (OG, n=41), which received LMWH sodium in addition to dydroges-terone. The study assessed changes in sex hormone levels, pre-thrombotic state (PTS) indices, thromboelastogram (TEG) parameters, and overall treatment outcomes before and after treatment.</p><p><strong>Results: </strong>Following treatment, E2, P, and HCG levels were significantly higher in the OG compared to the CG (P<0.05). Additionally, coagulation markers such as activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and plasminogen (PLG) were significantly elevated in the OG, while FIB and D-D levels were lower compared to the CG (P<0.05). TEG analysis showed that the OG exhibited higher R and K values, whereas MA, Angle, and CI values were lower than in the CG (P<0.05). The total response rate in the OG (95.12%) was significantly higher than in the CG (75.61%) (P<0.05). Additionally, the OG had lower rates of neonatal malformation, low birth weight, and mortality compared to the CG, with significant differences in malformation and low birth weight rates (P<0.05).</p><p><strong>Conclusions: </strong>Subcutaneous injection of LMWH sodium effectively improves sex hormone levels, reduces the risk of PTS, and enhances pregnancy outcomes in patients with adverse pregnancy and delivery. The therapy also improves coagulation and fibrinolytic markers, leading to better maternal and neonatal outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 6","pages":"1366-1375"},"PeriodicalIF":1.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12497467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}