Dalei Li, Kangwei Mao, Peiliang Luo, Ziqiang Zheng, Jiangyan Liu, Chenxi Zhang, Siyu Gu, Rui Zhang, Jun Sun, Juan Wang
{"title":"传染性单核细胞增多症患儿血清中白细胞介素-10、-22、-24和-26升高。","authors":"Dalei Li, Kangwei Mao, Peiliang Luo, Ziqiang Zheng, Jiangyan Liu, Chenxi Zhang, Siyu Gu, Rui Zhang, Jun Sun, Juan Wang","doi":"10.5937/jomb0-54625","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in serum samples of patients with infectious mononucleosis (IM) and the potential diagnostic values.</p><p><strong>Methods: </strong>Thirty children with IM were enrolled in the study, and serum samples were collected; 30 healthy children served as the controls. Serum samples from the patients and healthy controls were collected, and IL-10, -22, -24, and -26 were determined by the ELISA method. An automatic biochemical analyser detected the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Moreover, potential diagnostic values of IL-10, -22, -24 and -26 have been analysed using ROC curve analysis, and the correlation between the levels of IL-10, -22, -24 and -26 in patients was analysed. Correlation between IL-10, -22, -24, and -26 and ALT and AST were analysed.</p><p><strong>Results: </strong>IL-10, -22, -24, and -26 levels increased in serum samples of patients with IM compared to healthy controls. ROC analysis showed that the AUC of IL-10, -22, -24, and -26 were 0.8500, 0.7078, 0.8056, and 0.9167, respectively, suggesting that IL-10, -22, -24, and -26 were good biomarkers. Moreover, IL-10, -22, -24 and -26 levels were positively correlated with the ALT and AST of the patients.</p><p><strong>Conclusions: </strong>IL-10, -22, -24, and -26 were upregulated in the serum of patients with IM, suggesting they may function as potential biomarkers.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 4","pages":"776-783"},"PeriodicalIF":1.5000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363368/pdf/","citationCount":"0","resultStr":"{\"title\":\"Elevated interleukin-10, -22, -24, and -26 in serum samples of children with infectious mononucleosis.\",\"authors\":\"Dalei Li, Kangwei Mao, Peiliang Luo, Ziqiang Zheng, Jiangyan Liu, Chenxi Zhang, Siyu Gu, Rui Zhang, Jun Sun, Juan Wang\",\"doi\":\"10.5937/jomb0-54625\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in serum samples of patients with infectious mononucleosis (IM) and the potential diagnostic values.</p><p><strong>Methods: </strong>Thirty children with IM were enrolled in the study, and serum samples were collected; 30 healthy children served as the controls. Serum samples from the patients and healthy controls were collected, and IL-10, -22, -24, and -26 were determined by the ELISA method. An automatic biochemical analyser detected the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Moreover, potential diagnostic values of IL-10, -22, -24 and -26 have been analysed using ROC curve analysis, and the correlation between the levels of IL-10, -22, -24 and -26 in patients was analysed. Correlation between IL-10, -22, -24, and -26 and ALT and AST were analysed.</p><p><strong>Results: </strong>IL-10, -22, -24, and -26 levels increased in serum samples of patients with IM compared to healthy controls. ROC analysis showed that the AUC of IL-10, -22, -24, and -26 were 0.8500, 0.7078, 0.8056, and 0.9167, respectively, suggesting that IL-10, -22, -24, and -26 were good biomarkers. Moreover, IL-10, -22, -24 and -26 levels were positively correlated with the ALT and AST of the patients.</p><p><strong>Conclusions: </strong>IL-10, -22, -24, and -26 were upregulated in the serum of patients with IM, suggesting they may function as potential biomarkers.</p>\",\"PeriodicalId\":16175,\"journal\":{\"name\":\"Journal of Medical Biochemistry\",\"volume\":\"44 4\",\"pages\":\"776-783\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363368/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medical Biochemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5937/jomb0-54625\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5937/jomb0-54625","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Elevated interleukin-10, -22, -24, and -26 in serum samples of children with infectious mononucleosis.
Background: Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in serum samples of patients with infectious mononucleosis (IM) and the potential diagnostic values.
Methods: Thirty children with IM were enrolled in the study, and serum samples were collected; 30 healthy children served as the controls. Serum samples from the patients and healthy controls were collected, and IL-10, -22, -24, and -26 were determined by the ELISA method. An automatic biochemical analyser detected the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Moreover, potential diagnostic values of IL-10, -22, -24 and -26 have been analysed using ROC curve analysis, and the correlation between the levels of IL-10, -22, -24 and -26 in patients was analysed. Correlation between IL-10, -22, -24, and -26 and ALT and AST were analysed.
Results: IL-10, -22, -24, and -26 levels increased in serum samples of patients with IM compared to healthy controls. ROC analysis showed that the AUC of IL-10, -22, -24, and -26 were 0.8500, 0.7078, 0.8056, and 0.9167, respectively, suggesting that IL-10, -22, -24, and -26 were good biomarkers. Moreover, IL-10, -22, -24 and -26 levels were positively correlated with the ALT and AST of the patients.
Conclusions: IL-10, -22, -24, and -26 were upregulated in the serum of patients with IM, suggesting they may function as potential biomarkers.
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The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
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