Journal of International Medical Research最新文献

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Brain abscess caused by Mycobacterium tuberculosis in an immunocompetent patient: a case report and literature review. 由结核分枝杆菌引起的免疫功能正常患者脑脓肿:病例报告和文献综述。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241291469
Keyin Chen, Xuan Leng, Hui Zhou
{"title":"Brain abscess caused by <i>Mycobacterium tuberculosis</i> in an immunocompetent patient: a case report and literature review.","authors":"Keyin Chen, Xuan Leng, Hui Zhou","doi":"10.1177/03000605241291469","DOIUrl":"10.1177/03000605241291469","url":null,"abstract":"<p><p>Brain abscesses caused by <i>Mycobacterium tuberculosis</i> are rarely reported and are typically found in immunocompromised patients. The challenges in identifying the pathogen and the frequent delays in initiating appropriate therapy often result in a poor prognosis for patients. We herein report a rare case of a brain abscess caused by <i>M. tuberculosis</i> in a 63-year-old patient with a history of hypertension but no history of pulmonary tuberculosis. The patient was hospitalized twice because of worsening right upper limb weakness and speech difficulties. Both a pus culture and cerebrospinal fluid culture were negative. Ultimately, the diagnosis of <i>M. tuberculosis</i> infection was confirmed through next-generation sequencing and the tuberculosis-specific T-cell test (T-SPOT). The patient's symptoms improved following anti-tuberculosis treatment. This case highlights the importance of considering <i>M. tuberculosis</i> as a potential cause of brain abscesses, even in immunocompetent individuals, and underscores the need for early diagnosis for effective treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241291469"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary cement embolism: a rare complication of vertebroplasty. 肺水泥栓塞:椎体成形术的罕见并发症。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241291447
Eirik Tjønnfjord, Ai Phi Thuy Ho, Dag Ottar Sætre, Nezar Raouf
{"title":"Pulmonary cement embolism: a rare complication of vertebroplasty.","authors":"Eirik Tjønnfjord, Ai Phi Thuy Ho, Dag Ottar Sætre, Nezar Raouf","doi":"10.1177/03000605241291447","DOIUrl":"10.1177/03000605241291447","url":null,"abstract":"<p><p>This comprehensive case study aimed to highlight the condition of pulmonary embolism (PE), which despite its relative obscurity, may be more common than initially assumed. PE frequently occurs in the Emergency Department. PE along with deep vein thrombosis are the two most prevalent forms of venous thromboembolism (VTE). VTE ranks as the third most common cardiovascular condition encountered in the Emergency Department, following heart attacks and strokes. Acknowledging the symptoms of VTE and acting on them early are important to prevent chronic manifestations and heart failure in some cases owing to persisting pulmonary hypertension. One of the most frequent causes of VTE is surgery, which often occurs owing to immobilization. However, in some cases, VTE is due to the procedure itself or due to what is used in the procedure or injected in the patient. We report the case of a patient who complained of dyspnea for some time before diagnostic steps were taken, such as computed tomography and echocardiography. This case report describes the complication of PE due to vertebroplasty, which is well described but underdiagnosed because it may not be considered. More focus on this complication during follow-up could help diagnose and treat patients more rapidly.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241291447"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous rupture of broad ligament vein in twin pregnancy: a case report and literature review. 双胎妊娠宽韧带静脉自发性破裂:病例报告和文献综述。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241290898
Juan Zhu, Jiaoying Cheng, Huixia Yang
{"title":"Spontaneous rupture of broad ligament vein in twin pregnancy: a case report and literature review.","authors":"Juan Zhu, Jiaoying Cheng, Huixia Yang","doi":"10.1177/03000605241290898","DOIUrl":"10.1177/03000605241290898","url":null,"abstract":"<p><p>Spontaneous uterine vein rupture in pregnancy is rare. This current case report presents a case of broad ligament vein rupture in spontaneous twin pregnancy that is even rarer. A female in her early 30s at the third trimester of a twin pregnancy presented with headache and left upper abdominal pain for 2 days. After admission, her blood pressure was 158/112 mmHg accompanied with increased blood lipids and proteinuria. Ultrasonography did not show any abnormalities. The main diagnoses included twin pregnancy with abdominal pain of unknown aetiology, preeclampsia and hyperlipidaemia. Her blood pressure and symptoms did not improve after administration of medications. An emergency caesarean section and laparotomy were then performed. Intraoperatively, bright red non-coagulated blood was observed within the pelvis and removed. After two healthy female babies were delivered, pelvic exploration revealed haematomas in the broad ligaments bilaterally and haemostatic sutures and clips were applied to successfully treat the ruptured vein. In cases of unexplained abdominal pain accompanied with fetal distress and haemodynamic instability, especially in twin pregnancy that can cause uterus over-expansion and broad ligament over-stretch, the possibility of spontaneous uterine vein rupture should be considered. Rapid diagnosis, immediate fluid replacement and prompt surgical intervention are essential for the safety of the mother and child.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241290898"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complexities of complete androgen insensitivity syndrome: insights from a case report and literature review. 完全雄激素不敏感综合征的复杂性:从病例报告和文献综述中获得的启示。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241300058
Elene Asanidze, Jenaro Kristesashvili, Aleksandre Asanidze, Ana Jibladze, Giorgi Gaphrindashvili, Besik Asanidze, Ritika Bhatia
{"title":"Complexities of complete androgen insensitivity syndrome: insights from a case report and literature review.","authors":"Elene Asanidze, Jenaro Kristesashvili, Aleksandre Asanidze, Ana Jibladze, Giorgi Gaphrindashvili, Besik Asanidze, Ritika Bhatia","doi":"10.1177/03000605241300058","DOIUrl":"10.1177/03000605241300058","url":null,"abstract":"<p><p>Complete androgen insensitivity syndrome (CAIS) presents significant challenges in the accurate diagnosis and personalized management of individuals with a 46, XY karyotype who exhibit a female phenotype due to complete insensitivity to androgens. This retrospective case report analyzes the clinical data, genetic testing, hormonal profiling, and imaging studies of a patient who was initially misdiagnosed during hernioplasty and later misidentified as having Mayer-Rokitansky-Küster-Hauser syndrome. The report details the establishment of the correct diagnosis and implementation of a personalized management strategy that postponed gonadectomy until post-puberty. This approach included continuous monitoring and tailored estrogen replacement therapy, which facilitated informed patient decisions and comprehensive feminization while preventing the long-term consequences of estrogen deficiency. Supported by a literature review, this case report emphasizes the necessity of a multidisciplinary approach to managing CAIS, highlighting the importance of heightened awareness, accurate diagnostics, and personalized therapeutic plans to ensure holistic, patient-centered care.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300058"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type II cryoglobulinemia in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma and Sjögren's disease. 一名患有慢性淋巴细胞白血病/小淋巴细胞淋巴瘤和斯约格伦病的患者的 II 型低温球蛋白血症。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241285228
Renjie Bian, Xiaojing Yan, Chaoxu Zhang, Yuan Tao, Xiaoxue Wang
{"title":"Type II cryoglobulinemia in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma and Sjögren's disease.","authors":"Renjie Bian, Xiaojing Yan, Chaoxu Zhang, Yuan Tao, Xiaoxue Wang","doi":"10.1177/03000605241285228","DOIUrl":"10.1177/03000605241285228","url":null,"abstract":"<p><p>Type II cryoglobulinemia is a rare disorder characterized by abnormal immunoglobulins (Igs) precipitating in the blood at low temperatures and redissolving upon warming. Sjogren's disease (SjD) is an autoimmune disorder involving secretory gland malfunction that leads to persistent dryness of the mouth and eyes. Here, we report the case of a 61-year-old woman with a 7-year history of SjD who was diagnosed with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). However, her complicated clinical features could not be sufficiently explained by this disease alone. Immunofixation electrophoresis revealed monoclonal IgM-κ and polyclonal IgG-κ. The presence of precipitated cryoglobulin and elevated rheumatoid factor levels confirmed a diagnosis of type II cryoglobulinemia for this patient. To the best of our knowledge, this case represents the first report of a patient with CLL/SLL, SjD, and type II cryoglobulinemia, which increased our understanding of immune system-related disorders. Because certain similar mechanisms are involved in the pathogenesis of these three diseases, a combination treatment of rituximab, ibrutinib, and dexamethasone resulted in a favorable prognosis for this patient.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241285228"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on the potential correlation between polycystic ovary syndrome and periodontal disease. 多囊卵巢综合症与牙周病之间潜在相关性的研究进展。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241300096
Huishan Zhang, Xiaoping Lin
{"title":"Research progress on the potential correlation between polycystic ovary syndrome and periodontal disease.","authors":"Huishan Zhang, Xiaoping Lin","doi":"10.1177/03000605241300096","DOIUrl":"10.1177/03000605241300096","url":null,"abstract":"<p><p>Over the past few years, the correlation between periodontal disease (PD) and polycystic ovary syndrome (PCOS) has attracted widespread attention owing to the increased incidence of these diseases. Several studies have suggested a possible link between the two. In this narrative review, we examined the epidemiology, common risk factors, and pathological mechanisms of PCOS and PD to investigate the potential association between these diseases. Evidence from the literature indicates that PCOS and PD can interact with each other. Common risk factors, such as microbial homeostasis imbalance owing to dysbiosis, along with multiple hormone and inflammatory mediators, as well as inflammatory responses owing to oxidative stress and oxidative responses owing to ferroptosis, are all associated with the pathogenesis of both diseases. Further studies are needed to clarify the specific mechanisms of interaction between PCOS and PD, which could clarify future directions in disease management and combined multidisciplinary treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300096"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing chest pain in patients with acute coronary syndrome at Vietnam National Heart Institute: a case-control study. 越南国立心脏研究所急性冠状动脉综合征患者胸痛特征:一项病例对照研究。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241300009
Lan Anh Nguyen, Nhat Minh Pham, Manh Hung Pham, Hong Nhung Nguyen Thi, Hoai Nguyen Thi, Tuan Nguyen Huu
{"title":"Characterizing chest pain in patients with acute coronary syndrome at Vietnam National Heart Institute: a case-control study.","authors":"Lan Anh Nguyen, Nhat Minh Pham, Manh Hung Pham, Hong Nhung Nguyen Thi, Hoai Nguyen Thi, Tuan Nguyen Huu","doi":"10.1177/03000605241300009","DOIUrl":"10.1177/03000605241300009","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to distinguish chest pain characteristics between patients with and without acute coronary syndrome (ACS) at Vietnam National Heart Institute.</p><p><strong>Methods: </strong>A case-control study using a structured chest pain assessment questionnaire was performed to examine pain characteristics.</p><p><strong>Results: </strong>Smoking, a history of heart attack, and a family history of cardiovascular disease were associated with increased ACS-related chest pain risk. Patients without ACS more frequently reported left or central chest pain, mild discomfort, pain triggered by activity, and relief with rest or nitroglycerin. ACS-related chest pain was more often characterized by pain radiating to the back, a sensation of tightness or severe discomfort, gradual intensity increase, occurrence at rest or with minimal exertion, and accompanying sweating. No significant sex differences were found in ACS-related chest pain symptoms.</p><p><strong>Conclusions: </strong>Targeted assessment of chest pain features-such as pain radiation, pressure sensation, symptom escalation, duration, activity triggers, and relief factors-could improve public awareness and support the development of educational resources on ACS and non-ACS symptoms.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300009"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of blood eosinophil count on clinical outcomes in hospitalized Syrian patients with COPD exacerbation. 血嗜酸性粒细胞计数对叙利亚住院COPD加重患者临床结局的影响
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241299943
Sara Albuaini, Michel Najjar, Dania Tulaiba, Hussam Al Bardan
{"title":"Impact of blood eosinophil count on clinical outcomes in hospitalized Syrian patients with COPD exacerbation.","authors":"Sara Albuaini, Michel Najjar, Dania Tulaiba, Hussam Al Bardan","doi":"10.1177/03000605241299943","DOIUrl":"10.1177/03000605241299943","url":null,"abstract":"<p><strong>Objective: </strong>In this multicenter retrospective study, we evaluated the prognostic role of blood eosinophil count on clinical outcomes in hospitalized patients with exacerbations of chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>We included patients aged 20 to 90 years with a COPD diagnosis. Patients were divided into groups with blood eosinophil count ≤300 or >300 cells/μL and then further classified into 1-99, 100-300, or >300 cells/μL. We compared sociodemographic features and clinical outcomes between groups and identified risk factors associated with mortality in hospitalized patients with COPD and blood eosinophil count ≤300 cells/μL.</p><p><strong>Results: </strong>In total, 217 patients were included (82% men, average age 64.3±10.3 years). Patients with eosinophil counts ≤300 cells/μL had significantly longer hospital stays, more admissions to the intensive care unit (22.2% vs. 4.3%), and more frequent mechanical ventilation (21.6% vs. 4.3%) than those with eosinophil counts >300 cells/μL. Mortality only occurred in the group with ≤300 cells/μL; patients with COPD who had eosinophil counts >300 cells/μL had significantly better survival rates (17.0% vs. 0%).</p><p><strong>Conclusion: </strong>High blood eosinophil counts at admission were associated with improved short-term outcomes. Our findings reveal the importance of considering eosinophil counts in clinical decision-making to manage hospitalized patients with COPD.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241299943"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and risk factors of malnutrition among patients receiving hemodialysis in a tertiary level hospital in Mauritius. 毛里求斯一家三级医院接受血液透析的病人营养不良的流行情况和危险因素。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241300008
Kevin Fagoonee, Ganessen Chinien, Neelesh Munnohur
{"title":"Prevalence and risk factors of malnutrition among patients receiving hemodialysis in a tertiary level hospital in Mauritius.","authors":"Kevin Fagoonee, Ganessen Chinien, Neelesh Munnohur","doi":"10.1177/03000605241300008","DOIUrl":"10.1177/03000605241300008","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to determine the prevalence of malnutrition and its associated risk factors among patients undergoing hemodialysis in a tertiary hospital in Mauritius.</p><p><strong>Methods: </strong>We enrolled 250 participants in this cross-sectional single-center study. A modified Malnutrition-Inflammation Score (MIS) questionnaire was used. We collected and analyzed data pertaining to patients' medical and hemodialysis details.</p><p><strong>Results: </strong>Among the 250 enrolled participants, 136 (54.4%) were male patients. Participants had been undergoing hemodialysis for a mean duration of 5.67 ± 4.66 years. Malnutrition was present in 108 (43.2%) participants, and 176 patients (70.4%) had diabetes mellitus, which was found to be a significant predictor of malnutrition. There was a significant correlation between malnutrition and the number of years a participant had been under hemodialysis, as well as female sex. A significant variation in MIS values was found among different age groups. Participants with malnutrition had lower body mass index and hyponatremia.</p><p><strong>Conclusions: </strong>Malnutrition is an important issue, particularly among women, patients who have been on hemodialysis for an extended period, those with older age, and patients with diabetes mellitus.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300008"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors for and short-term prognosis of intrauterine infection in preterm infants. 早产儿宫内感染的风险因素和短期预后。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-11-01 DOI: 10.1177/03000605241286728
Xuemei Zhao, Yue Song, Liqun Lu
{"title":"Risk factors for and short-term prognosis of intrauterine infection in preterm infants.","authors":"Xuemei Zhao, Yue Song, Liqun Lu","doi":"10.1177/03000605241286728","DOIUrl":"10.1177/03000605241286728","url":null,"abstract":"<p><strong>Objective: </strong>To identify the risk factors for and short-term prognosis of intrauterine infection (IUI) in preterm infants.</p><p><strong>Methods: </strong>We retrospectively collected clinical data regarding preterm infants (28<sup>+0</sup>-36<sup>+6</sup> weeks of gestational age) with IUI from the neonatal intensive care unit of our hospital between June 2017 and June 2022. The pathologic characteristics of the infants were classified using the Redline criteria, and the resulting groups were compared with respect to their clinical characteristics, indicators of infection, complications, and mortality rates.</p><p><strong>Results: </strong>Three hundred thirty (78.1%) of the 422 enrolled neonates showed signs of histologic IUI; 51.8% showed histologic chorioamnionitis alone, and 48.2% showed both histologic chorioamnionitis and funisitis. The independent risk factors identified for IUI were maternal prenatal invasive manipulation, premature rupture of membranes (>18 hours before labor), and prenatal C-reactive protein concentration. The infants with IUI showed higher incidences of respiratory distress syndrome, bronchopulmonary dysplasia, retinopathy of prematurity, and prolonged mechanical ventilation. Low gestational age and low birth weight of preterm infants were significantly associated with a higher incidence of histologic IUI, more severe inflammation, and a higher incidence of complications.</p><p><strong>Conclusions: </strong>Histologic IUI is associated with high complication and mortality rates in preterm infants, as is an increasing severity of inflammation.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241286728"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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