Journal of International Medical Research最新文献_第7页

Recurrent single-organ cutaneous small-vessel vasculitis with streptococcal infection in a pediatric patient: A case report. 复发单器官皮肤小血管炎伴链球菌感染的儿科患者：1例报告。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.1177/03000605251368334

Min Yang, Xiuying Chen, Zhihua Zhang, Lijuan Hu, Yannan Guo, Songhui Zhai

引用次数: 0

Multiple injections of indocyanine green for improving the outcomes of lymphatic-venous anastomosis reconstruction of lymphatic return under microscopy: A case report. 多次注射吲哚菁绿改善显微镜下淋巴-静脉吻合重建的疗效1例。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1177/03000605251375258

Haoxiang Zhu, Huipeng Zhu, Yuanjie Bao

{"title":"Multiple injections of indocyanine green for improving the outcomes of lymphatic-venous anastomosis reconstruction of lymphatic return under microscopy: A case report.","authors":"Haoxiang Zhu, Huipeng Zhu, Yuanjie Bao","doi":"10.1177/03000605251375258","DOIUrl":"10.1177/03000605251375258","url":null,"abstract":"This study explores effective treatment methods for chronic secondary lymphedema after radical cervical cancer surgery combined with pelvic lymphadenectomy. In cases where conservative treatment was ineffective, we investigated whether multiple injections of indocyanine green can effectively improve the outcomes of lymphatic-venous anastomosis under microscopy. Preoperative lymphatic imaging was used to localize functional vessels, guiding distal left lower limb lymphatic reconstruction. Intraoperatively, supermicroscopy (40×) and real-time indocyanine green imaging enabled eight end-to-end anastomoses between 0.5- and 1.3-mm lymphatic capillaries and subcutaneous veins. Each anastomosis took ≤30 min, with intraoperative lymphangiography confirming patency. Immediate postoperative lymphatic diversion to veins was observed. By day 3, reconstructed pathway efficiency reached 83% of the healthy side, with visual analog scale pain scores decreasing from 5 to 2. At 3-6 months, mid-thigh and calf circumferences reduced progressively; ultrasound confirmed edema resolution and complete cessation of exudation. High-precision multipoint supermicrosurgical anastomosis achieved anatomical and functional reconstruction of chronic secondary lymphedema, overcoming traditional size and functional limitations. Innovations included multipoint design to prevent reobstruction and dynamic imaging-guided precision. This case establishes a radical treatment strategy for chronic secondary lymphedema.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375258"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of angiotensin-converting enzyme 2 gene polymorphisms with hypertension and treatment response to hydroxychloroquine in Iranian people with coronavirus disease 2019: A cross-sectional study. 血管紧张素转换酶2基因多态性与伊朗2019冠状病毒病患者高血压和羟氯喹治疗反应的关联：一项横断面研究

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-23 DOI: 10.1177/03000605251375221

Farzaneh Jafary, Mohammad Kazemi, Maryam Zarean, Mehri Khoshhali, Maryam Karimian, Fataneh Fani, Kiana Shahzamani

{"title":"Association of angiotensin-converting enzyme 2 gene polymorphisms with hypertension and treatment response to hydroxychloroquine in Iranian people with coronavirus disease 2019: A cross-sectional study.","authors":"Farzaneh Jafary, Mohammad Kazemi, Maryam Zarean, Mehri Khoshhali, Maryam Karimian, Fataneh Fani, Kiana Shahzamani","doi":"10.1177/03000605251375221","DOIUrl":"10.1177/03000605251375221","url":null,"abstract":"ObjectiveThe mechanism of severe acute respiratory syndrome coronavirus 2 in infecting human cells requires binding of the virus to angiotensin-converting enzyme 2. Angiotensin-converting enzyme 2 is also involved in blood pressure regulation. There are several single-nucleotide polymorphisms in the angiotensin-converting enzyme 2 genome. As the occurrence of clinical symptoms and response to different treatments in patients with coronavirus disease 2019 are different, it seems that single-nucleotide polymorphisms can play a role in these differences. This receptor became important during the coronavirus disease 2019 pandemic because the coronavirus can enter host cells via this receptor. In this study, we aimed to discover the correlation between ACE2 gene polymorphism, hypertension, and anti-coronavirus disease 2019 drug usage in patients with coronavirus disease 2019.MethodsWe performed a cross-sectional study, and two polymorphisms, rs1978124 and rs2158083, were analyzed in 75 patients with essential hypertension and coronavirus disease 2019. All patients were genotyped using sequencing analysis methods, and the correlation between polymorphism, hypertension, severity of other diseases, and treatment response to anti-coronavirus disease 2019 drugs was determined using SPSS 20.0.ResultsThere was no significant association between single-nucleotide polymorphisms and the risk of being hypertensive with other diseases and the risk of diabetes in unadjusted and adjusted models in patients with coronavirus disease 2019 (P > 0.05).ConclusionNo significant association was found between single-nucleotide polymorphisms and hypertension in patients with coronavirus disease 2019.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375221"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neovascular glaucoma associated with central retinal vein occlusion in a young patient with hyperlipidemia. 年轻高脂血症患者伴视网膜中央静脉闭塞的新生血管性青光眼。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-24 DOI: 10.1177/03000605251379254

Iden Amiri, Meredith R Klifto, Alice Yang Zhang

{"title":"Neovascular glaucoma associated with central retinal vein occlusion in a young patient with hyperlipidemia.","authors":"Iden Amiri, Meredith R Klifto, Alice Yang Zhang","doi":"10.1177/03000605251379254","DOIUrl":"10.1177/03000605251379254","url":null,"abstract":"This case report presents a rare instance of neovascular glaucoma secondary to central retinal vein occlusion in a previously healthy man in his early 30s who exhibited acute unilateral vision loss, ocular pain, and elevated intraocular pressure. Ophthalmic imaging, including ultra-widefield fundus photography and optical coherence tomography, revealed retinal hemorrhages, intraretinal fluid, and iris neovascularization consistent with ischemic central retinal vein occlusion and secondary neovascular glaucoma. Notably, systemic evaluation revealed severe hyperlipidemia associated with the patient's strict nonvegetarian diet, with no other identifiable risk factors. Treatment included intravitreal antivascular endothelial growth factor injections, Ahmed glaucoma valve implantation, and panretinal photocoagulation followed by pars plana vitrectomy. The patient experienced partial visual recovery after the initiation of lipid-lowering therapy and dietary counseling. This case underscores the importance of considering modifiable metabolic factors, particularly extreme dietary patterns, in young patients presenting with central retinal vein occlusion. It supports the incorporation of systemic lipid screening and dietary assessment into the diagnostic workup of atypical retinal vascular events. Although causality cannot be established, this case advocates the need for further investigation into the systemic implications of diet-related hyperlipidemia in ocular vascular disease.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379254"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stepwise cannulation of the small saphenous vein for thrombolysis: A technique to optimize clot removal and reduce the severity of post-thrombotic syndrome. 小隐静脉逐步插管溶栓：一种优化血栓清除和降低血栓后综合征严重程度的技术。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-24 DOI: 10.1177/03000605251379528

Haoxiang Zhu, Huipeng Zhu

{"title":"Stepwise cannulation of the small saphenous vein for thrombolysis: A technique to optimize clot removal and reduce the severity of post-thrombotic syndrome.","authors":"Haoxiang Zhu, Huipeng Zhu","doi":"10.1177/03000605251379528","DOIUrl":"10.1177/03000605251379528","url":null,"abstract":"A retrospective analysis was conducted on the clinical data of 50 patients with acute mixed-type lower extremity deep vein thrombosis treated at the Affiliated People's Hospital of Ningbo University. All patients underwent catheter-directed thrombolysis via small saphenous vein access. The thrombolytic catheter was inserted into the deep venous thrombus through either infrapopliteal deep veins or the popliteal vein. Continuous infusion of urokinase via a microinfusion pump was administered at a dose of (178.32 ± 79.45) × 104 U for direct clot dissolution. The efficacy was evaluated by comparing the pre-operative and post-operative circumferences of the upper and lower knees, venous patency scores, and thrombolysis rates. Post-operatively, all patients in the group showed significant improvement in symptoms after thrombolysis. Among the 50 patients who were treated, the pre-operative versus post-operative reduction in suprapatellar circumference difference was 74% ± 6% and the pre-operative versus post-operative reduction in infrapatellar circumference difference was 78% ± 6%. The venous patency score significantly improved (P < 0.01), with a thrombolysis rate of 78% ± 6%. No serious complications occurred during the treatment process. This study shows that direct thrombolysis through the saphenous vein catheter for acute mixed-type lower limb deep vein thrombosis is a safe, effective, and feasible treatment method.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379528"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explainable ResNet-long short-term memory model for the classification of bowel sounds frequency based on multifeature fusion. 基于多特征融合的可解释的resnet长短期记忆模型肠音频率分类。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-30 DOI: 10.1177/03000605251376915

Wenchao Zhang, Yu Wang, Jinzhou Zhu, Qiang Wu, Congying Xu, Lihe Liu, Shiqi Zhu, Xiaolin Liu, Jiaxi Lin, Chenyan Yu, Qi Yin, Xianglin Ding, Zhonghua Xu

{"title":"Explainable ResNet-long short-term memory model for the classification of bowel sounds frequency based on multifeature fusion.","authors":"Wenchao Zhang, Yu Wang, Jinzhou Zhu, Qiang Wu, Congying Xu, Lihe Liu, Shiqi Zhu, Xiaolin Liu, Jiaxi Lin, Chenyan Yu, Qi Yin, Xianglin Ding, Zhonghua Xu","doi":"10.1177/03000605251376915","DOIUrl":"10.1177/03000605251376915","url":null,"abstract":"ObjectiveTo develop an explainable ResNet-long short-term memory model based on multifeature fusion for classifying bowel sound frequency-a key indicator of gastrointestinal motility. Accurate and objective classification of bowel sound activity levels holds significant clinical value in clinical settings.MethodsAs a prospective multicenter study conducted across three medical institutions, the primary outcome involved three-way classification of bowel sounds as normoactive, hyperactive, or hypoactive. Bowel sounds were collected and segmented into 10-s clips. Audio features-Chroma, Filter Bank Energies, and Mel-Frequency Cepstral Coefficients-were extracted to train deep learning models using transfer learning with ResNet50 V2, followed by feature fusion and classification via long short-term memory and automated machine learning methods.ResultsThe independent test demonstrated superior performance of the long short-term memory model, achieving an accuracy of 0.927, Matthew's correlation coefficient of 0.885, and weighted Cohen's kappa of 0.930-outperforming both automated machine learning models and gastroenterologists. Additionally, the model was evaluated in two clinical scenarios: (a) feeding timing after general anesthesia and (b) bowel preparation for colonoscopy, showing high sensitivity and specificity. Local interpretable model-agnostic explanations were used to enhance model transparency.ConclusionsThis framework offers a novel, accurate, and explainable approach for bowel sound classification, demonstrating strong potential for clinical applications in gastrointestinal function assessment.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251376915"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of desmoplastic fibroblastoma in a 2-year-old child. 2岁儿童纤维母细胞瘤1例报告。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-30 DOI: 10.1177/03000605251379965

Yihao Tian, Jian Ming

引用次数: 0

Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus. 甘油三酯葡萄糖指数与时间范围的关系：一项基于2型糖尿病患者的横断面研究

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-26 DOI: 10.1177/03000605251381190

Hongbo Shang, Xiaoli Qin, Wenxian Li, Yanrong Xu, Weixuan Wang

{"title":"Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus.","authors":"Hongbo Shang, Xiaoli Qin, Wenxian Li, Yanrong Xu, Weixuan Wang","doi":"10.1177/03000605251381190","DOIUrl":"10.1177/03000605251381190","url":null,"abstract":"ObjectiveThe objective of this study was to investigate the relationship between the triglyceride glucose index and time in range in patients with type 2 diabetes mellitus.MethodsThis is a cross-sectional study based on patients with type 2 diabetes mellitus. The time in range was measured in all patients using continuous glucose monitoring. Differential analyses were performed to compare the differences in clinical information between groups. Linear regression and logistic regression techniques were employed to construct a novel predictive model that encompassed the triglyceride glucose index, with the aim of assessing time in range attainment. The predictive value of the new model was then assessed using receiver operator characteristic curves.ResultsLinear and logistic regression analyses showed a significant negative correlation between the triglyceride glucose index and time in range, identifying the triglyceride glucose index as an independent risk factor for time in range attainment. Furthermore, restricted cubic spline plots indicated a nonlinear correlation between the triglyceride glucose index and time in range. The area under the curve of the novel prediction model constructed on the basis of the triglyceride glucose index for predicting time in range attainment was 0.81, thus demonstrating efficacious clinical application.ConclusionsThe study revealed a nonlinear relationship between the triglyceride glucose index and time in range, highlighting the triglyceride glucose index as a crucial indicator of time in range attainment.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251381190"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracheal diverticulum as a cause of ventilation failure after intubation: A case report and review of the literature. 气管憩室作为气管插管后通气失败的原因：1例报告及文献复习。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-26 DOI: 10.1177/03000605251379521

Shanshan He, Bo Tao, Teng He

{"title":"Tracheal diverticulum as a cause of ventilation failure after intubation: A case report and review of the literature.","authors":"Shanshan He, Bo Tao, Teng He","doi":"10.1177/03000605251379521","DOIUrl":"10.1177/03000605251379521","url":null,"abstract":"Tracheal diverticulum is a rare and easily overlooked complication following tracheoesophageal fistula repair that poses substantial challenges in airway management for anesthesiologists. We present a case of a 4-month-old girl with esophageal stenosis following tracheoesophageal fistula repair who was presented for repeated endoscopic balloon dilation. During the first two inductions of general anesthesia, endotracheal intubation appeared successful but resulted in unexpected ventilation failure. Successful ventilation was finally achieved after multiple attempts at intubation. Fiberoptic bronchoscopy revealed a tracheal diverticulum before the third induction of anesthesia, explaining the persistent ventilation difficulties. The patient was successfully managed with fiberoptic bronchoscopy-guided intubation while maintaining spontaneous respiration, allowing the endotracheal tube to bypass the diverticulum. This case highlights tracheal diverticulum as an uncommon cause of ineffective ventilation following intubation and suggests that fiberoptic bronchoscopy-guided intubation may be a preferable approach.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379521"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case report of esophageal neuroendocrine carcinoma mimicking a submucosal tumor: Diagnosis confirmed by endoscopic ultrasound-guided fine-needle aspiration. 食管神经内分泌癌模拟粘膜下肿瘤1例：经超声内镜引导下细针穿刺确诊。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-26 DOI: 10.1177/03000605251381453

Chunxiao Hu, Di Zhu, Ping Li, Xiaohua Ye, Zhiyi Chen

{"title":"A rare case report of esophageal neuroendocrine carcinoma mimicking a submucosal tumor: Diagnosis confirmed by endoscopic ultrasound-guided fine-needle aspiration.","authors":"Chunxiao Hu, Di Zhu, Ping Li, Xiaohua Ye, Zhiyi Chen","doi":"10.1177/03000605251381453","DOIUrl":"10.1177/03000605251381453","url":null,"abstract":"Esophageal neuroendocrine carcinoma is an exceedingly rare and aggressive malignancy, accounting for less than 1% of all esophageal cancers. This case report presents a unique instance of esophageal neuroendocrine carcinoma that initially manifests as a submucosal tumor-like lesion, an atypical and under-recognized presentation that can mimic benign conditions such as leiomyomas or gastrointestinal stromal tumors. Conventional endoscopic biopsy, often the first-line diagnostic tool, failed to provide a definitive diagnosis due to the tumor's deep submucosal location and intact overlying mucosa. However, the utilization of endoscopic ultrasound-guided fine-needle aspiration proved instrumental in obtaining sufficient tissue for histopathological and immunohistochemical analyses, confirming the diagnosis of esophageal neuroendocrine carcinoma. This case underscores the critical role of endoscopic ultrasound-guided fine-needle aspiration in diagnosing rare esophageal malignancies that evade standard diagnostic approaches. Furthermore, it emphasizes the importance of considering esophageal neuroendocrine carcinoma in the differential diagnosis of unusual esophageal lesions, particularly when they exhibit unusual features or fail to respond to conventional management. Early and accurate diagnosis is essential for guiding appropriate therapeutic strategies and improving patient outcomes.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251381453"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0