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Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605241311437
Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Safeena Khan, Ammara Tahir, Muhammad Haris Khan, Touba Azeem, Abdul Moeez, Arysha Monis, Aban Masaud Mian, Fazia Khattak, Moosa Ali, Jibran Ikram
{"title":"Efficacy and safety of laquinimod versus placebo in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.","authors":"Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Safeena Khan, Ammara Tahir, Muhammad Haris Khan, Touba Azeem, Abdul Moeez, Arysha Monis, Aban Masaud Mian, Fazia Khattak, Moosa Ali, Jibran Ikram","doi":"10.1177/03000605241311437","DOIUrl":"10.1177/03000605241311437","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the safety and efficacy of laquinimod in treating relapsing-remitting multiple sclerosis (RRMS).</p><p><strong>Methods: </strong>An extensive electronic search was conducted across PubMed, Embase, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov to identify suitable studies. Risk of bias was assessed using Cochrane's Risk of Bias tool. Statistical analysis was performed using RevMan 5.4.1.</p><p><strong>Results: </strong>The meta-analysis of four randomized controlled trials including 3665 patients found that laquinimod significantly reduced the annualized relapse rate compared with placebo (mean difference = -0.08, 95% confidence interval [CI] = -0.12, -0.04, <i>I</i><sup>2</sup> = 0%). For disability progression confirmed at 3 months, laquinimod provided a significant advantage over placebo (hazard ratio [HR] = 0.75, 95% CI = 0.59, 0.96, <i>I</i><sup>2</sup> = 25%), whereas no benefit was achieved at 6 months (HR = 0.69, 95% CI = 0.45, 1.06, <i>I</i><sup>2</sup> = 66%). Laquinimod was also significantly better than placebo in maintaining a relapse-free status (risk ratio [RR] = 1.14 95% CI = 1.06, 1.22, <i>I</i><sup>2</sup> = 10%). Laquinimod had a comparable safety profile as placebo (RR = 1.06, 95% CI = 0.81, 1.39, <i>I</i><sup>2</sup> = 33%).</p><p><strong>Conclusions: </strong>These findings support the efficacy of laquinimod in managing RRMS but necessitate careful monitoring during treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605241311437"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistence of giant cell arteritis and subacute thyroiditis: A case report and literature review.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315333
Cheng Xu, Yongmei Han
{"title":"Coexistence of giant cell arteritis and subacute thyroiditis: A case report and literature review.","authors":"Cheng Xu, Yongmei Han","doi":"10.1177/03000605251315333","DOIUrl":"10.1177/03000605251315333","url":null,"abstract":"<p><p>Giant cell arteritis and subacute thyroiditis are often regarded as clinically distinct diseases with differing pathogenesis. We report a rare case of coexisting giant cell arteritis and subacute thyroiditis that were both successfully managed using glucocorticoid therapy. Ultrasound plays a vital role in the diagnosis and treatment of these diseases. A review of the literature revealed that cases of giant cell arteritis complicated by subacute thyroiditis are very rare, and their pathogenesis and association are still unclear. We summarized the clinical features of giant cell arteritis complicated with subacute thyroiditis and found that none of the patients had symptoms associated with polymyalgia rheumatica. Subacute thyroiditis could be misdiagnosed as giant cell arteritis, and ultrasound is a useful tool for distinguishing the two diseases. Glucocorticoids are effective in the active period in patients with giant cell arteritis complicated with subacute thyroiditis. This case report would encourage clinicians to pay more attention to this phenomenon.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315333"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carcinoma of the ampulla of Vater with membranous nephropathy: a case report. 壶腹癌合并膜性肾病1例。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251317966
Hua Jie, Qian Yongsheng, Chen Wenli
{"title":"Carcinoma of the ampulla of Vater with membranous nephropathy: a case report.","authors":"Hua Jie, Qian Yongsheng, Chen Wenli","doi":"10.1177/03000605251317966","DOIUrl":"10.1177/03000605251317966","url":null,"abstract":"<p><p>Nephrotic syndrome can occur secondary to malignancy, and its resolution is sometimes observed following tumor resection. We herein report the case of a 67-year-old Asian man who presented with membranous nephropathy associated with carcinoma of the ampulla of Vater. The patient initially presented with edema, hypoalbuminemia, and significant proteinuria with positive PLA2R antibody. Following surgical removal of the tumor, his urinary protein levels normalized, his serum albumin returned to normal, and the nephrotic syndrome achieved complete remission. This case underscores the importance of screening for secondary causes, such as malignancies, in patients with nephrotic syndrome. For those with malignancy-associated nephrotic syndrome, prompt and targeted treatment of the underlying tumor is critical to avoid missing the window for surgical intervention. This report aims to provide insights into the diagnosis and management of tumor-associated nephrotic syndrome, contributing to a better understanding of this rare clinical entity.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251317966"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral ureteral endometriosis masquerading as a ureteral tumor and resulting in complete loss of renal function: A case report. 单侧输尿管子宫内膜异位症伪装成输尿管肿瘤，导致肾功能完全丧失：1例报告。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251322252
Rui Qu, Luo Yang, Yi Dai
{"title":"Unilateral ureteral endometriosis masquerading as a ureteral tumor and resulting in complete loss of renal function: A case report.","authors":"Rui Qu, Luo Yang, Yi Dai","doi":"10.1177/03000605251322252","DOIUrl":"10.1177/03000605251322252","url":null,"abstract":"<p><p>Ureteral endometriosis is a rare manifestation of endometriosis that involves the infiltration of endometrial tissue into the ureters, leading to ureteral obstruction and potential renal dysfunction. However, its preoperative diagnosis is difficult. Herein, we report the case of a woman in her early 50s who presented with severe hydronephrosis of the right kidney, ureteral dilation, and suspicion of a ureteral tumor based on initial imaging studies. However, the pathological results after resection of the right kidney and right ureter revealed the presence of endometrial tissue in an ectopic location. This case highlights the importance of considering endometriosis as a differential diagnosis in cases of ureteral obstruction, even in atypical clinical scenarios, and emphasizes the need for prompt diagnosis and intervention to prevent irreversible renal damage and optimize patient outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251322252"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visceral leishmaniasis related secondary haemophagocytic syndrome: A case report. 内脏利什曼病相关继发性噬血细胞综合征1例报告。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251318204
Chen Chen, Yankun Yu, Long Zhen Zhu Ma, Jing Nin, Daqian Zhang, Weixia Nong, Xin Pan
{"title":"Visceral leishmaniasis related secondary haemophagocytic syndrome: A case report.","authors":"Chen Chen, Yankun Yu, Long Zhen Zhu Ma, Jing Nin, Daqian Zhang, Weixia Nong, Xin Pan","doi":"10.1177/03000605251318204","DOIUrl":"10.1177/03000605251318204","url":null,"abstract":"<p><p>Visceral leishmaniasis (VL) is a parasitic disease that can trigger haemophagocytic syndrome (HPS), making its prompt diagnosis crucial. The application of metagenome next-generation sequencing (mNGS) provides a rapid diagnostic approach, particularly for patients with negative bone marrow aspiration results. We present here, a case of a male patient in his early 50s who presented with fever and abdominal pain. Routine examinations failed to identify its specific cause. However, diagnosis through mNGS helped prevent a potentially fatal outcome.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251318204"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Totally ultrasound-guided percutaneous nephrolithotomy in a patient with severe scoliosis: a case report and review of the literature. 全超声引导下经皮肾镜取石术治疗重度脊柱侧凸1例报告及文献复习。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315921
Liqun Huang, Dongyang Li, Yuansheng Yan, Rongbing Li, Jie Huang, Jing Ye, Guosheng Yang, Xuelei Wang
{"title":"Totally ultrasound-guided percutaneous nephrolithotomy in a patient with severe scoliosis: a case report and review of the literature.","authors":"Liqun Huang, Dongyang Li, Yuansheng Yan, Rongbing Li, Jie Huang, Jing Ye, Guosheng Yang, Xuelei Wang","doi":"10.1177/03000605251315921","DOIUrl":"10.1177/03000605251315921","url":null,"abstract":"<p><p>Complete staghorn calculi present one of the most challenging conditions in managing upper urinary tract stones. The complexity of treatment increases significantly when combined with severe scoliosis, particularly in patients with a Cobb angle exceeding 90°. This case report describes the treatment of a patient with severe scoliosis, characterized by a Cobb angle greater than 90°, who also presented with complete staghorn calculi. The patient successfully underwent single-stage, totally ultrasound-guided, tubeless mini-percutaneous nephrolithotomy, achieving excellent stone clearance without complications. This report aims to enhance the understanding of diagnosing and managing severe scoliosis in patients with complete staghorn calculi and to highlight the efficacy and safety of totally ultrasound-guided mini-percutaneous nephrolithotomy as a surgical approach.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315921"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral widespread inflammatory linear verrucous epidermal nevus with ipsilateral limb contracture along the lines of Blaschko: A case report. 沿Blaschko线单侧广泛炎性线状疣状表皮痣伴同侧肢体挛缩1例报告。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251318201
Wanxing Zhang, Jiao Ma, Shijun Shan, Haihui Su
{"title":"Unilateral widespread inflammatory linear verrucous epidermal nevus with ipsilateral limb contracture along the lines of Blaschko: A case report.","authors":"Wanxing Zhang, Jiao Ma, Shijun Shan, Haihui Su","doi":"10.1177/03000605251318201","DOIUrl":"10.1177/03000605251318201","url":null,"abstract":"<p><p>Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare type of epidermal nevus characterized by an inflammatory appearance, intense pruritus, and a tendency to be resistant to treatment. We present here, the case of a 7-year-old boy who presented with a widespread inflammatory skin lesion on the right side of his body, with some of the eruption following Blaschko's lines. He also had an associated contracture in the ipsilateral limb and short stature. Initially, we suspected this may be a rare case of CHILD syndrome in a boy. However, after further investigation, we confirmed the diagnosis as a severe form of ILVEN.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251318201"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of amino acid and lipid metabolism in patients with spondyloarthritis. 脊椎关节炎患者的氨基酸和脂质代谢失调。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251313949
Constantin Remus, Meike Hoffmeister, Selina Strathmeyer, Steffen Heelemann, Inga Claus, Werner Dammermann, Oliver Ritter, Daniel Patschan, Susann Patschan
{"title":"Dysregulation of amino acid and lipid metabolism in patients with spondyloarthritis.","authors":"Constantin Remus, Meike Hoffmeister, Selina Strathmeyer, Steffen Heelemann, Inga Claus, Werner Dammermann, Oliver Ritter, Daniel Patschan, Susann Patschan","doi":"10.1177/03000605251313949","DOIUrl":"10.1177/03000605251313949","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a metabolomics analysis in patients with spondyloarthritis (SpA) and compare results with those from healthy controls. The overall goal was to identify small-molecule substances that may have potential pathogenic and diagnostic significance in SpA.</p><p><strong>Methods: </strong>This was an observational, cross-sectional, single-centre study that included patients with axial (ankylosing spondylitis [AS]), peripheral (psoriatic arthritis [PsA]) and healthy controls.</p><p><strong>Results: </strong>The study included 50 patients with AS, 50 patients with PsA, and 164 controls. When compared with healthy controls, patients with SpA showed significant differences in 35 metabolites, primarily associated with amino acid and lipid metabolism. However, only two differences were found between the AS and PsA cohorts (glucose and glycerol).</p><p><strong>Conclusions: </strong>Our data suggest that patients with SpA exhibit significant disruptions in amino acid and lipid metabolism. The large number of identified metabolites offers promising opportunities, both for discovering new SpA biomarkers and for gaining a deeper understanding of the pathophysiology of these chronic inflammatory diseases.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251313949"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251318195
Jun Fukae, Yoshiharu Amasaki, Yuichiro Fujieda, Yuki Sone, Ken Katagishi, Tatsunori Horie, Tamotsu Kamishima, Tatsuya Atsumi
{"title":"Pre-trained convolutional neural network with transfer learning by artificial illustrated images classify power Doppler ultrasound images of rheumatoid arthritis joints.","authors":"Jun Fukae, Yoshiharu Amasaki, Yuichiro Fujieda, Yuki Sone, Ken Katagishi, Tatsunori Horie, Tamotsu Kamishima, Tatsuya Atsumi","doi":"10.1177/03000605251318195","DOIUrl":"10.1177/03000605251318195","url":null,"abstract":"<p><strong>Objective: </strong>To study the classification performance of a pre-trained convolutional neural network (CNN) with transfer learning by artificial joint ultrasonography images in rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>This retrospective study focused on abnormal synovial vascularity and created 870 artificial joint ultrasound images based on the European League Against Rheumatism/Outcome Measure in Rheumatology scoring system. One CNN, the Visual Geometry Group (VGG)-16, was trained with transfer learning using the 870 artificial images for initial training and the original plus five additional images for second training. The models were then tested for the ability to classify joints using real joint ultrasound images obtained from patients with RA. The study was registered in UMIN Clinical Trials Registry (UMIN000054321).</p><p><strong>Results: </strong>A total of 156 clinical joint ultrasound images from 74 patients with RA were included. The initial model showed moderate classification performance, but the area under curve (AUC) for grade 1 synovitis was particularly low (0.59). The second model showed improvement in classifying grade 1 synovitis (AUC 0.73).</p><p><strong>Conclusions: </strong>Artificial images may be useful for training VGG-16. The present novel approach of using artificial images as an alternative to actual images for training a CNN has the potential to be applied in medical imaging fields that face difficulties in collecting real clinical images.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251318195"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous amino acids for kidney protection in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315919
Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Aban Masaud Mian, Abdul Moeez, Waqas Inayat, Bushra Noor, Izhar Ali Shah, Muhammad Osama, Bushra Khan, Muhammad Sajid, Touba Azeem, Mohammad Ebad Ur Rehman, Ashraf Ali, Ubaid Khan Afridi
{"title":"Intravenous amino acids for kidney protection in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.","authors":"Malik Waleed Zeb Khan, Aizaz Ali, Amna Hussain, Aban Masaud Mian, Abdul Moeez, Waqas Inayat, Bushra Noor, Izhar Ali Shah, Muhammad Osama, Bushra Khan, Muhammad Sajid, Touba Azeem, Mohammad Ebad Ur Rehman, Ashraf Ali, Ubaid Khan Afridi","doi":"10.1177/03000605251315919","DOIUrl":"10.1177/03000605251315919","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of intravenous (IV) amino acids in preventing acute kidney injury (AKI) in patients undergoing cardiac surgery.</p><p><strong>Methods: </strong>PubMed, EMBASE, and Cochrane Library databases were systematically searched for all relevant randomised controlled trials (RCTs) published from inception to July 25, 2024. A random effects model was used to pool the risk ratios (RR) for dichotomous outcomes, and the combined data was visually represented using forest plots.</p><p><strong>Results: </strong>3 studies involving 3646 patients were included in the meta-analysis. IV amino acids did not significantly lower the overall AKI incidence compared with control measures. However, they significantly reduced the risk of Stage 1 AKI and Stage 3 AKI. No differences were observed between intervention and control for Stage 2 AKI or need for kidney replacement therapy.</p><p><strong>Conclusion: </strong>IV amino acids may offer protective benefits against severe AKI stages in cardiac surgery patients. Further studies are warranted to validate our findings.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315919"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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