Journal of International Medical Research最新文献

{"title":"Analysis of a case of severe pancreatitis complicated with preeclampsia.","authors":"Xiaoling Xin, Ying Cao, Yaling Liu, Xi Chen, Kaili Wei, Xuan Peng, Wenyan Cai, Jiaxi Yao","doi":"10.1177/03000605251342670","DOIUrl":"10.1177/03000605251342670","url":null,"abstract":"<p><p>Preeclampsia combined with pancreatitis is a rare condition in pregnant and postpartum women, potentially leading to severe complications. Severe pancreatitis is even more uncommon, making early diagnosis, detection, and appropriate treatment essential. We report the case of a 34-year-old woman who was admitted with scleral jaundice; severe pancreatitis was identified during examination. After magnetic resonance imaging confirmation, prompt and appropriate treatment was provided, resulting in a favorable outcome.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251342670"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic potential of irisin in alleviating acute lung injury via inflammation and ferroptosis modulation.","authors":"Feng Zhang, Jiangpeng Wang, Wei Wang, Gang Chen, Huan Tang, Xuezhen Zhai","doi":"10.1177/03000605251340338","DOIUrl":"10.1177/03000605251340338","url":null,"abstract":"<p><p>ObjectiveAcute lung injury is a fatal complication triggered by sepsis, characterized by widespread inflammation and weakening of the alveolar epithelium. Irisin has been reported to exert anti-inflammatory effects, which are produced by the cleavage of fibronectin type III domain-containing protein 5 in skeletal muscle. Here, we investigated the potential of irisin in preventing acute lung injury by protecting the alveolar epithelium.MethodsThe sepsis-related acute lung injury model was established by a cecal ligation and puncture model in C57/BL6N mice. Lung histology was assessed using hematoxylin and eosin and Masson staining. Ferroptosis-related proteins and genes were quantified via western blot and quantitative polymerase chain reaction, respectively, whereas cytokine levels were measured using enzyme-linked immunosorbent assay.ResultsHistological analysis revealed lung injury in the cecal ligation and puncture group, alongside elevated levels of cytokines such as IL-1β, IL-18, and TNF-α compared with controls. Treatment with irisin mitigated sepsis-induced lung damage and reduced oxidative stress, as indicated by reactive oxygen species and Fe²⁺ levels. Furthermore, irisin pretreatment inhibited the upregulation of ferroptosis-related genes (<i>Acsl4</i>, <i>Ptgs2</i>, and <i>Hspa5</i>) as well as ACSL4, COX-2, and p-AMPK expression.ConclusionThese findings suggest that irisin treatment is associated with reduced ferroptosis and inflammation in sepsis-induced acute lung injury. Irisin emerges as a promising candidate for acute lung injury therapy induced by sepsis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340338"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could it be <i>Brucella melitensis</i>? Recognizing and managing a rare pathogen in periprosthetic infections.","authors":"Mehmet Süleyman Abul, Ömer Faruk Sevim, Muhammed Enes Karataş, Furkan Başak","doi":"10.1177/03000605251337568","DOIUrl":"10.1177/03000605251337568","url":null,"abstract":"<p><p>Periprosthetic joint infections caused by <i>Brucella melitensis</i> are rare and present significant diagnostic and therapeutic challenges, especially in endemic regions such as Anatolia. The indolent nature of <i>Brucella</i> infections often results in subclinical presentations, complicating early detection and management. This case series highlights the importance of recognizing <i>Brucella melitensis</i> as a potential pathogen in periprosthetic joint infection and explores the treatment options for this condition. Herein, we present five cases of <i>Brucella melitensis</i>-associated periprosthetic joint infections involving three hip replacements and two knee replacements. Diagnoses were confirmed through advanced diagnostic techniques, including prolonged cultures and serological testing, as routine methods often yielded negative results. Two patients underwent one-stage revision arthroplasty, two underwent two-stage revision arthroplasty, and one patient was managed conservatively with targeted antibiotics due to the absence of prosthetic loosening. All patients showed excellent functional recovery and infection eradication at follow-up, with normalized inflammatory markers and no evidence of recurrence. This case series emphasizes the importance of clinical suspicion and the use of advanced diagnostics in endemic areas for timely recognition of <i>Brucella</i>-associated periprosthetic joint infections. One-stage revision arthroplasty combined with prolonged antibiotic therapy demonstrated favorable outcomes and may serve as an effective treatment strategy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337568"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"HPV infection status among women of all ages in Jinshan District, Shanghai\".","authors":"","doi":"10.1177/03000605251348811","DOIUrl":"10.1177/03000605251348811","url":null,"abstract":"","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251348811"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac angiosarcoma in acute pericardial tamponade with hemoptysis: A case report.","authors":"Song Yang, Fangchen Gong, Dava Tenzing, Nana Tong, Erzhen Chen, Enqiang Mao, Yongjie Ding, Ying Chen, Yihui Wang","doi":"10.1177/03000605251339142","DOIUrl":"10.1177/03000605251339142","url":null,"abstract":"<p><p>Primary cardiac angiosarcoma is a relatively rare tumor that frequently metastasizes by the time of diagnosis, with a poor prognosis. Currently, there is no uniform treatment, with surgical resection, radiotherapy, and chemotherapy being the mainstays of treatment. We report the case of a man in his early 30s who presented to the emergency department with hemoptysis and was found to have massive pericardial effusion and right atrial occupancy upon investigation. Subsequent examination revealed hypermetabolic foci in the lungs and femur, and a final biopsy confirmed the presence of a primary cardiac angiosarcoma. The patient died 3 days after diagnosis due to cardiopulmonary failure, with a survival period of 4 months from symptom onset to death. This report describes one of the few cases of cardiac tumor with respiratory symptoms.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251339142"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient osteoporosis of the hip and fatty liver disease: Case report and pathogenic hypothesis.","authors":"Marco Paoletta, Antimo Moretti, Sara Liguori, Francesca Gimigliano, Giovanni Iolascon","doi":"10.1177/03000605251334239","DOIUrl":"10.1177/03000605251334239","url":null,"abstract":"<p><p>Transient osteoporosis of the hip is a rare, temporary condition characterized by hip pain and functional limitations, which can significantly reduce the quality of life. Bone marrow edema of the proximal femur, identified through magnetic resonance imaging is the primary diagnostic feature of transient osteoporosis of the hip. While the exact cause of transient osteoporosis of the hip remains unclear, several potential pathophysiological mechanisms warrant further investigation to better understand this condition. In this case study, we present an unusual case of a patient with transient osteoporosis of the hip who was diagnosed with non-alcoholic fatty liver disease. A 42-year-old Caucasian man presented with left hip pain. After clinical and radiological evaluations, he was diagnosed with transient osteoporosis of the hip. Biochemical assessment revealed a persistent and isolated elevation of alanine aminotransferase. The patient underwent a treatment regimen involving 16 days of intramuscular neridronate along with physical therapy. At the 3- and 6-month follow-ups, he showed significant improvements in both clinical symptoms and radiological findings. In our study, we propose, for the first time, a potential association between liver disorders, specifically non-alcoholic fatty liver disease, and the onset of transient osteoporosis of the hip, exploring the possible pathophysiological mechanisms connecting these two conditions and discuss the rationale for both pharmacological and non-pharmacological treatments.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251334239"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case report: Bladder endometriosis at the urachus.","authors":"Jiale Deng, Guanqun Wang, Yu Yang, Mengying Liao, Liangkuan Bi, Benlin Wei","doi":"10.1177/03000605251340535","DOIUrl":"10.1177/03000605251340535","url":null,"abstract":"<p><p>Endometriosis is an uncommon condition, and its occurrence in the urachus is exceptionally rare. This case report highlights the extreme rarity of bladder endometriosis involving the urachal area. To the best of our knowledge, no such cases have been previously reported in the literature. The clinical presentation and imaging findings of this condition are extremely similar to those of urachal carcinoma, which makes the differential diagnosis particularly challenging. In this case, a 34-year-old woman presented with significant bladder irritative symptoms during menstruation. Imaging revealed a mass in the urachal region, but its characteristics remained uncertain. Cystoscopy showed only bladder compression, and the patient ultimately underwent robot-assisted laparoscopic partial cystectomy. Postoperative pathology confirmed the diagnosis of bladder endometriosis. This case underscores the importance of considering bladder endometriosis in the differential diagnosis of masses in the urachal area, particularly when they resemble urachal cancer. Early surgical intervention and histopathological confirmation are essential to prevent disease progression.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340535"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oxidative balance scores with the prevalence of prediabetes, impaired fasting glucose, and impaired glucose tolerance in the general US adult population: Evidence from NHANES 1999-2018.","authors":"Hongpeng Guo, Junjie Zhang, Ying Qi, Chenglin Sun, Ji Wu","doi":"10.1177/03000605251340616","DOIUrl":"10.1177/03000605251340616","url":null,"abstract":"<p><p>ObjectiveOxidative stress likely contributes to the pathogenesis of prediabetes. The oxidative balance score is an emerging metric for quantifying exposure to dietary and lifestyle oxidative stress. This study aimed to investigate the association between oxidative balance score and the prevalence of prediabetes, impaired fasting glucose, and impaired glucose tolerance based on data from the National Health and Nutrition Examination Survey 1999-2018.MethodsIn this cross-sectional study, the oxidative balance score was derived from 16 dietary and 4 lifestyle components, as outlined in previous research. Prediabetes, impaired fasting glucose, and impaired glucose tolerance were diagnosed based on the American Diabetes Association criteria. Multivariate logistic regression models were employed to analyze these associations.ResultsIn total, 22,960 participants with a mean age of 44.7 years were included in this study. In fully adjusted models, dietary oxidative balance score, lifestyle oxidative balance score, and overall oxidative balance score were all inversely associated with the prevalence of prediabetes among the general US adult population (odds ratios and 95% confidence intervals of 0.956 (0.949, 0.963), 0.914 (0.891, 0.937), and 0.957 (0.950, 0.964), respectively; all p <0.0001). Compared with quartile 1, dietary oxidative balance score, lifestyle oxidative balance score, and overall oxidative balance score at quartile 4 were all associated with a significantly lower prevalence of prediabetes (odds ratios and 95% confidence intervals 0.515 (0.449, 0.591), 0.834 (0.740, 0.940), and 0.505 (0.440, 0.579), respectively; all p for trend <0.0001). Similar results were observed for impaired fasting glucose and impaired glucose tolerance. Restricted cubic spline analysis showed that most of the associations were nonlinear and that significant negative correlations were observed only after a certain threshold. Stratified and sensitivity analyses confirmed the robustness of the findings.ConclusionsAdherence to an antioxidant-rich diet and healthy lifestyle may aid in the prevention of prediabetes, impaired fasting glucose, and impaired glucose tolerance among the general US adult population. Further cohort studies are needed to validate these findings.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340616"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Myoepithelioma-like hyalinizing epithelioid tumors of the palm: A case report\".","authors":"","doi":"10.1177/03000605251347336","DOIUrl":"10.1177/03000605251347336","url":null,"abstract":"","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251347336"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-like ovarian endometriosis with pregnancy decidua reaction: A case report and review of the literature.","authors":"Yu-Rou Zhang, Zhi-Li Li, Li Guo","doi":"10.1177/03000605251342519","DOIUrl":"10.1177/03000605251342519","url":null,"abstract":"<p><p>We describe a case of bilateral ovarian tumor-like lesions detected during pregnancy. It is important to highlight that these masses were not detected for the first time during pregnancy; the patient had already been aware of them 2 years prior, during pregnancy preparation, when an ultrasound examination revealed bilateral space-occupying ovarian lesions. These lesions did not exhibit any increase in size during regular follow-ups until pregnancy. At 17 weeks of gestation, fetal ultrasound showed significant enlargement of the bilateral ovarian lesions. The patient underwent pelvic magnetic resonance imaging, which revealed cystic masses in both the ovaries with septations and multiple nodular and flocculent projections on the walls and septations, exhibiting features resembling malignant tumors. The cystic fluid within each cyst predominantly showed slightly short T1 and long T2 signal characteristics. The final diagnosis of lesions occupying the ovarian space was endometriotic cysts with a decidual reaction associated with pregnancy, which was confirmed on postoperative pathological examination. Subsequently, at 19 weeks of gestation, the patient underwent a \"laparoscopic excision of the left ovarian lesion and right ovarian lesion stripping.\" The patient recovered well postoperatively and successfully delivered a baby at 39 weeks of gestation. Endometriosis with decidual reaction during pregnancy is rare and ectopic decidual tissue can easily be confused with neoplastic lesions using imaging results. In addition, clinicians must remain vigilant about the special conditions that ectopic decidual tissue may cause, such as cyst rupture, massive hemorrhage, dystocia, and even fetal death.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251342519"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}