Journal of International Medical Research最新文献_第6页

Epistaxis due to hereditary hemorrhagic telangiectasia: A case report and literature review. 遗传性出血性毛细血管扩张致鼻出血1例并文献复习。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI: 10.1177/03000605251374630

Xiangnan Du, Yuting Lu, Xiaoxiao Luo, Xiaolin Cao

{"title":"Epistaxis due to hereditary hemorrhagic telangiectasia: A case report and literature review.","authors":"Xiangnan Du, Yuting Lu, Xiaoxiao Luo, Xiaolin Cao","doi":"10.1177/03000605251374630","DOIUrl":"10.1177/03000605251374630","url":null,"abstract":"Characterized by abnormalities of the blood vessel wall, hereditary hemorrhagic telangiectasia is an autosomal dominant disorder. Recurrent or spontaneous epistaxis is the most prevalent symptom of hereditary hemorrhagic telangiectasia, whose severity varies greatly, ranging from moderate self-limiting epistaxis to severe, life-threatening epistaxis, which often requires multiple treatments and is therefore a challenge for otorhinolaryngologists. This case report retrospectively analyzed the clinical data and family history of a patient who presented to the Department of Otorhinolaryngology, Hangzhou First People's Hospital, with recurrent epistaxis for 60 years. The patient was treated with Little's area septomucotomy combined with electrocoagulation for epistaxis, and her clinical symptoms and specialty findings showed significant improvement after four postoperative follow-up visits. This article reviews the possible mechanisms and treatment progress of epistaxis caused by hereditary hemorrhagic telangiectasia, with the aim of improving diagnosis and clinical management of this disease.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251374630"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcatheter aortic valve implantation in a patient with isolated aortic regurgitation using JenaValve. JenaValve应用于孤立性主动脉反流患者的经导管主动脉瓣植入术。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-05 DOI: 10.1177/03000605251369848

Lina Xia, Wei Peng, Li Chen, Li Li

引用次数: 0

Cross-disciplinary risk prediction for muscle weakness and physical decline in older adults: A machine learning model integrating social determinants of health and clinical characteristics. 老年人肌肉无力和身体衰退的跨学科风险预测：整合健康和临床特征的社会决定因素的机器学习模型。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-26 DOI: 10.1177/03000605251379211

Bowen Li, Wenjing Li, Chunxiao Wan

{"title":"Cross-disciplinary risk prediction for muscle weakness and physical decline in older adults: A machine learning model integrating social determinants of health and clinical characteristics.","authors":"Bowen Li, Wenjing Li, Chunxiao Wan","doi":"10.1177/03000605251379211","DOIUrl":"10.1177/03000605251379211","url":null,"abstract":"BackgroundWith the aging population, muscle weakness and physical decline are pressing public health concerns. Health outcomes are influenced by both physiological factors and social determinants of health; however, the interplay between these remains underexplored.ObjectiveThis study aimed to identify risk factors for muscle weakness and physical decline in older adults, integrating physiological and social determinants of health variables, and develop a predictive model for early risk assessment.MethodsUsing prospective China Health and Retirement Longitudinal Study data with 9-year follow-up data (baseline predictors from 2011, outcomes from 2020), logistic regression, recursive feature elimination, and XGBoost algorithms were applied to construct predictive models.ResultsKey risk factors included age, ethnicity, cognitive function, and physical activity. Social determinants of health variables such as marital status, life satisfaction, and educational level were significant predictors. SHapley Additive exPlanations analysis revealed that social determinants of health variables significantly enhanced model performance and interpretability.ConclusionIntegrating social determinants of health with clinical indicators improves the prediction of muscle weakness and physical decline in older adults. The study highlights the need for personalized interventions that consider both physiological and social factors, offering valuable insights for public health policy and health management in the aging population.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379211"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression analysis of NOD-like receptor protein 3 and interleukin-18 in basal cell carcinoma: A case-control study. nod样受体蛋白3和白细胞介素-18在基底细胞癌中的表达分析：一项病例对照研究。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-26 DOI: 10.1177/03000605251379519

Zahra Mehrabi, Zohreh Rahimi, Parisa Mohammadi, Nazanin Jalilian, Lida Haghnazari, Farhad Salari, Soheila Asadi

{"title":"Expression analysis of NOD-like receptor protein 3 and interleukin-18 in basal cell carcinoma: A case-control study.","authors":"Zahra Mehrabi, Zohreh Rahimi, Parisa Mohammadi, Nazanin Jalilian, Lida Haghnazari, Farhad Salari, Soheila Asadi","doi":"10.1177/03000605251379519","DOIUrl":"10.1177/03000605251379519","url":null,"abstract":"ObjectiveThis study aimed to investigate the expression of the inflammasome-related molecules NOD-like receptor protein 3 and interleukin-18 in basal cell carcinoma tissues and to evaluate their potential as diagnostic biomarkers.MethodsIn this observational case-control study, tumor tissues and adjacent noncancerous tissue samples from 25 patients with basal cell carcinoma were analyzed. We quantified NOD-like receptor protein 3 and interleukin-18 expression at the mRNA and protein levels using quantitative real-time polymerase chain reaction and western blotting, respectively. The diagnostic performance of these molecules was assessed using receiver operating characteristic curve analysis.ResultsOur results revealed that both NOD-like receptor protein 3 and interleukin-18 were significantly upregulated in basal cell carcinoma tissues compared with adjacent noncancerous tissue samples at the mRNA and protein levels (p < 0.05). Receiver operating characteristic curve analysis demonstrated strong diagnostic performance, with an area under the curve of 0.931 for NOD-like receptor protein 3 (95% confidence interval: 0.845-1.00) and 0.860 for interleukin-18 (95% confidence interval: 0.739-0.980).ConclusionsThe marked upregulation of NOD-like receptor protein 3 and interleukin-18 suggests their involvement in the inflammatory tumor microenvironment and positions them as promising candidate biomarkers for basal cell carcinoma detection. Although these findings may suggest their relevance as future therapeutic targets, this role requires substantial validation through functional assays and in larger, more diverse study populations.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379519"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral decompression during unilateral transforaminal lumbar interbody fusion significantly reduces contralateral radiculopathy: A retrospective analysis. 单侧椎间孔腰椎椎间融合术中双侧减压显著减少对侧神经根病：回顾性分析。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI: 10.1177/03000605251374637

Cem Sever, Bekir Eray Kilinc, Oguzhan Cakir, Hamit Kahraman Caglayan, Ahmet Onur Akpolat

{"title":"Bilateral decompression during unilateral transforaminal lumbar interbody fusion significantly reduces contralateral radiculopathy: A retrospective analysis.","authors":"Cem Sever, Bekir Eray Kilinc, Oguzhan Cakir, Hamit Kahraman Caglayan, Ahmet Onur Akpolat","doi":"10.1177/03000605251374637","DOIUrl":"10.1177/03000605251374637","url":null,"abstract":"ObjectiveTo determine the effectiveness of bilateral decompression combined with a unilateral transforaminal lumbar interbody fusion approach in centralizing a lordotic cage and preventing contralateral radiculopathy by ensuring equal foraminal elevation.MethodsThis is a retrospective cohort study based on clinical records and radiological data. Eighty-seven patients diagnosed with lumbar spinal stenosis at L3-S1 levels underwent bilateral decompression and transforaminal lumbar interbody fusion between 2017 and 2022. The procedures were performed through a posterior midline incision, followed by insertion of a lordotic cage to restore spinal alignment. Fluoroscopy and microscopy confirmed the precise placement of the cage. Clinical outcomes were assessed using visual analog scale and Oswestry disability index scores, with radiological evaluations through computed tomography and magnetic resonance imaging.ResultsPostoperative imaging demonstrated the centralization of the lordotic cage in both anteroposterior and lateral planes, ensuring equal foraminal elevation bilaterally. The visual analog scale and Oswestry disability index scores significantly improved at all follow-up intervals. The incidence of contralateral radiculopathy was minimized (1%) due to prophylactic decompression, and the foraminal area increased by more than 20%.ConclusionsBilateral decompression combined with a unilateral transforaminal lumbar interbody fusion approach enables effective stabilization and alignment of spinal segments. The central placement of the lordotic cage contributes to symmetrical foraminal elevation, reducing the risk of contralateral radiculopathy.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251374637"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of chylous pleural and peritoneal effusions in a cirrhotic patient: A case report and review of literature. 肝硬化患者乳糜胸膜及腹膜积液的处理：1例报告及文献复习。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI: 10.1177/03000605251371631

Xuegui Ju, Yaguang Li

引用次数: 0

Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009-2018. 美国成年人胆固醇、高密度脂蛋白和葡萄糖指数与2型糖尿病患病率之间的关系：一项基于2009-2018年全国健康与营养检查调查的横断面研究

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-12 DOI: 10.1177/03000605251375557

Zhe Zhang, Mengting Chen, Dong Cai, Mengzhen Fan, Yang Wang

{"title":"Association between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes mellitus prevalence in US adults: A cross-sectional study based on National Health and Nutrition Examination Survey 2009-2018.","authors":"Zhe Zhang, Mengting Chen, Dong Cai, Mengzhen Fan, Yang Wang","doi":"10.1177/03000605251375557","DOIUrl":"10.1177/03000605251375557","url":null,"abstract":"ObjectiveTo investigate the association between the cholesterol, high-density lipoprotein, and glucose (CHG) index and type 2 diabetes mellitus prevalence in US adults.MethodsThis cross-sectional study included 11,390 participants from the National Health and Nutrition Examination Survey 2009-2018 cycles. The CHG index was calculated using total cholesterol, high-density lipoprotein, and fasting blood glucose levels. Weighted logistic regression was used to assess the association between the CHG index and type 2 diabetes mellitus prevalence, and restricted cubic spline analysis was applied to examine potential nonlinear relationships. Receiver operating characteristic curves were used to evaluate the diagnostic performance of the CHG index, and the results were compared with those of the triglyceride-glucose index.ResultsA higher CHG index was significantly associated with increased type 2 diabetes mellitus prevalence (odds ratio: 4.30, 95% confidence interval: 3.21-5.77, p < 0.001) after adjusting for multiple confounders. Restricted cubic spline analysis showed a nonlinear relationship, demonstrating an elevated risk of type 2 diabetes mellitus in patients with a CHG index of >5.24. The association remained consistent across all subgroups. The CHG index demonstrated good predictive value (area under the curve = 0.721; optimal cutoff = 5.47; sensitivity = 0.53; specificity = 0.80), comparable to that of the triglyceride-glucose index (area under the curve = 0.730; optimal cutoff = 8.84; sensitivity = 0.62; specificity = 0.73).ConclusionThe CHG index may be associated with type 2 diabetes mellitus prevalence and could serve as a simple, accessible biomarker for early risk identification. Further prospective studies are needed to validate its clinical utility.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375557"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A direct association between suicide and reduced amygdala volume: A retrospective study. 自杀与杏仁核体积减小之间的直接联系：一项回顾性研究。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-29 DOI: 10.1177/03000605251380424

Elif Emre, Sevler Yildiz, Ayse Rumeysa Yaman Baran, Gulhan Kilicarslan, Suna Aydin, Esra Piril Agirbas, Burcu Sirlier Emir, İbrahim Sahin, Suleyman Aydin

{"title":"A direct association between suicide and reduced amygdala volume: A retrospective study.","authors":"Elif Emre, Sevler Yildiz, Ayse Rumeysa Yaman Baran, Gulhan Kilicarslan, Suna Aydin, Esra Piril Agirbas, Burcu Sirlier Emir, İbrahim Sahin, Suleyman Aydin","doi":"10.1177/03000605251380424","DOIUrl":"10.1177/03000605251380424","url":null,"abstract":"ObjectiveThe neurological causes of suicide remain poorly understood. This study sought to ascertain whether there is a correlation between amygdala volume and suicidal behavior.MethodsThis case-control retrospective study included 193 participants-108 healthy controls and 85 individuals with a history of suicide attempts. Sagittal magnetic resonance imaging was conducted for each participant, and cross-sectional areas of the left and right amygdala were determined independently using freehand tracing. The total volume of the amygdala was determined by multiplying the thickness of the slices by the sum of the regions.ResultsPatients with a history of suicide attempts had significantly decreased amygdala volumes on both the right (p = 0.018) and left (p = 0.036) sides compared with controls. Receiver operating characteristic analysis determined a cutoff value of 1825 mm³ for both hemispheres. The cutoff sensitivity and specificity for the right amygdala were 30.6% and 88%, whereas the values for the left amygdala were 31.8% and 84.3%, respectively.ConclusionsThis is the first study to show that individuals who had attempted suicide had considerably decreased left and right amygdala volumes, with receiver operating characteristic analysis indicating good specificity (84.3%-88%). According to these findings, a reduced amygdala volume might be a useful biomarker for identifying those who are at risk of attempting suicide.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251380424"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and feasibility of computed tomography-guided radiofrequency ablation for treating high-risk pulmonary nodules in postoperative lung cancer patients. ct引导下射频消融治疗肺癌术后高危肺结节的安全性和可行性。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-30 DOI: 10.1177/03000605251382006

Xiang Lin, Jian Zhou, Beinuo Wang, Zhenghao Dong, Junjie Zhang, Fan Liu, Hu Liao

{"title":"Safety and feasibility of computed tomography-guided radiofrequency ablation for treating high-risk pulmonary nodules in postoperative lung cancer patients.","authors":"Xiang Lin, Jian Zhou, Beinuo Wang, Zhenghao Dong, Junjie Zhang, Fan Liu, Hu Liao","doi":"10.1177/03000605251382006","DOIUrl":"10.1177/03000605251382006","url":null,"abstract":"BackgroundLung cancer remains the leading cause of cancer-related deaths globally. Patients with postoperative recurrence typically have limited treatment options. This study evaluated the safety and feasibility of computed tomography-guided radiofrequency ablation for treating high-risk pulmonary nodules in patients who have undergone lung cancer surgery and are ineligible for reoperation.MethodsWe retrospectively analyzed 40 patients (16 men and 24 women, aged 41-78 years) with radiologically suspicious recurrent nodules following lung cancer resection who were treated with radiofrequency ablation at West China Hospital (July 2023-August 2024). Outcomes included procedural success, occurrence of complications, hospitalization duration, 30-day mortality, and imaging response.ResultsAll procedures were technically successful. Five minor complications occurred in 12.5% of the patients, including fever (n = 2) and pneumothorax (n = 3). No deaths occurred within 30 days, and no major adverse events (e.g. hemothorax) were observed. The median postoperative length of hospital stay after ablation was 2.0 days. Furthermore, 82.5% of the patients were followed up and had achieved complete ablation at the 3-month mark.ConclusionComputed tomography-guided radiofrequency ablation is a minimally invasive, safe, and effective option for managing high-risk pulmonary nodules in postoperative lung cancer patients who are deemed ineligible for reoperation. Its low complication rate, rapid recovery, and promising local control support its integration into multimodal treatment algorithms. Larger prospective studies are needed to validate long-term outcomes.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251382006"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Death caused by transdermal ivermectin poisoning: A case report and literature review. 伊维菌素经皮中毒致死亡1例并文献复习。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-22 DOI: 10.1177/03000605251377690

He Yin, Peng-Shu Zhang, Yu Chen, Bing-Bing Kong, Chen-Guang Zhang, Sheng Wu

{"title":"Death caused by transdermal ivermectin poisoning: A case report and literature review.","authors":"He Yin, Peng-Shu Zhang, Yu Chen, Bing-Bing Kong, Chen-Guang Zhang, Sheng Wu","doi":"10.1177/03000605251377690","DOIUrl":"10.1177/03000605251377690","url":null,"abstract":"Ivermectin is a classic antiparasitic drug that is widely used around the world. After the outbreak of coronavirus disease 2019, many studies have reported the potential effectiveness of ivermectin against coronavirus disease 2019; however, it is not recommended by the World Health Organization because of insufficient evidence and significant adverse effects. Owing to the abovementioned findings, the number of reports of poisoning and other serious reactions caused by ivermectin abuse have increased in recent years. Notably, no previous cases of transdermal ivermectin poisoning with documented blood concentrations has been reported to date. We report a rare fatal case of ivermectin misuse with a review of recent literature. The patient suffered from ivermectin poisoning due to transdermal overdose. The patient's plasma concentration was 27 ng/mL. The main clinical manifestations were gastrointestinal symptoms in the early stage and diffuse cerebral edema and intracranial hypertension in the later stage. Despite active treatment, including hemoperfusion and cardiorespiratory support, the patient died. Many recent in vitro studies have shown that ivermectin has the potential to become a new anticancer drug. If clinical research proves its effectiveness against cancer, it may also lead to ivermectin overuse. This study aimed to raise awareness regarding ivermectin poisoning among clinicians and the public, thereby preventing drug abuse.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251377690"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0