Journal of International Medical Research最新文献_第5页

Primary umbilical endometriosis: clinical aspects and long-term follow-up of five cases.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251317815

MengHui Li, KunNing Zhang, ChongDong Liu

引用次数: 0

Linezolid and serotonin syndrome.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315355

Haytham A Wali

{"title":"Linezolid and serotonin syndrome.","authors":"Haytham A Wali","doi":"10.1177/03000605251315355","DOIUrl":"https://doi.org/10.1177/03000605251315355","url":null,"abstract":"Linezolid, a synthetic oxazolidinone antibiotic, is used to treat gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus. Despite its efficacy, linezolid can cause serotonin syndrome, a potentially fatal condition associated with excessive serotonin activity in the brain. This narrative review examined the pharmacological mechanisms of this interaction, particularly linezolid's mild monoamine oxidase-inhibitory activity, which can trigger serotonin syndrome in combination with serotonergic drugs. Serotonin syndrome causes cognitive, autonomic, and somatic symptoms ranging from mild (tremors, diarrhea) to severe (hyperthermia, seizures, multiorgan failure). The Hunter Serotonin Toxicity Criteria have superior sensitivity and specificity over the Sternbach Criteria for diagnosis. Clinical evidence indicates that although the incidence of linezolid-induced serotonin syndrome is low, the risk justifies careful monitoring and risk assessment. This review emphasizes enhanced pharmacovigilance and standardized reporting criteria to better capture and analyze data on linezolid-induced serotonin syndrome. Assessments of the pharmacological mechanisms, large-scale clinical trials, and cohort studies are essential to elucidate risk factors and outcomes. Developing comprehensive clinical guidelines and education programs for healthcare providers is crucial to improve linezolid's safety profile. Exploring pharmacogenomic approaches and alternative therapies with lower serotonin syndrome risks is recommended to enhance patient outcomes while maintaining linezolid's efficacy in treating severe bacterial infections.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315355"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac computed tomography for cardiac masses: a necessity or a luxury?

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605241306604

Imane Joudar, Siham Nasri, Imane Kamaoui, Imane Skiker

{"title":"Cardiac computed tomography for cardiac masses: a necessity or a luxury?","authors":"Imane Joudar, Siham Nasri, Imane Kamaoui, Imane Skiker","doi":"10.1177/03000605241306604","DOIUrl":"10.1177/03000605241306604","url":null,"abstract":"Cardiac masses present a considerable diagnostic challenge because of their diverse causes and potential clinical implications. Traditional imaging methods, such as transthoracic echocardiography and transesophageal echocardiography, are crucial for initial assessments owing to their accessibility, but they have a major limitation represented by inter-operator variability. Therefore, cardiac computed tomography (CT) has become an indispensable adjunct, providing detailed anatomical information and tissue characterization. This review examines the prevalence, categorization and diagnostic benefits of cardiac CT in the evaluation of cardiac masses. The high-resolution imaging and multiplanar features of cardiac CT allow in-depth assessment of the structure, location and enhancement patterns of masses, helping to distinguish benign from malignant masses and guide clinical decision-making. Specific imaging features of benign and malignant tumors, as well as non-neoplastic masses, are discussed, highlighting the role of CT in overall cardiac assessment. This article highlights the importance of CT in surgical preparation, risk assessment and ongoing monitoring, and highlights its effect on improving patients' outcomes. With continued advances in CT technology, the integration of this modality into routine clinical practice should improve the accuracy of diagnosis and management of cardiac masses, strengthening the essential role of cardiac CT as a vital component of contemporary cardiovascular imaging.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605241306604"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605241311115

Mortada H F El-Shabrawi, Gamal Eltagy, Mohamed Qinawy, Mohammed Am Oshi, Amjad Algethami, Nawaf A Alhujayri, Shaker S Alharthi, Abdullah M Alelyani, Naglaa M Kamal

{"title":"Early Kasai portoenterostomy in a 9-day-old newborn with extrahepatic biliary atresia: a case report highlighting improved prognosis with prompt intervention.","authors":"Mortada H F El-Shabrawi, Gamal Eltagy, Mohamed Qinawy, Mohammed Am Oshi, Amjad Algethami, Nawaf A Alhujayri, Shaker S Alharthi, Abdullah M Alelyani, Naglaa M Kamal","doi":"10.1177/03000605241311115","DOIUrl":"10.1177/03000605241311115","url":null,"abstract":"Extrahepatic biliary atresia (EHBA) is a leading cause of neonatal cholestasis, often resulting in end-stage cirrhosis and portal hypertension without early diagnosis and treatment. This report highlights the importance of timely intervention, describing a 6-day-old male newborn diagnosed with EHBA who underwent successful Kasai portoenterostomy at 9 days of age. While the procedure is typically performed within the first 60 days of life, this exceptionally early intervention led to significantly improved outcomes. Postoperative recovery was marked by bilirubin normalization within 2 months and steady improvement in liver function tests, demonstrating the advantages of early surgery. The procedure involved creating a Roux-en-Y hepatic portojejunostomy to restore bile flow, preventing progression to biliary cirrhosis. Early intervention achieved effective bile drainage and substantial clinical improvement. At the 1-year follow-up, the infant displayed normal growth and liver function. This case supports the hypothesis that performing Kasai portoenterostomy earlier than current guidelines recommend may lead to better outcomes. It underscores the need for vigilant neonatal care to recognize early signs of cholestasis and enable prompt surgical intervention. Early diagnosis and intervention can preserve liver function, potentially delaying or preventing the need for liver transplantation.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605241311115"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depressive symptoms delayed but subsequently led to the diagnosis of transthyretin amyloidosis: a case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251318000

Vladimir Knezevic, Dragana Ratkovic, Zeljko Zivanovic, Masa Comic, Jelena Knezevic, Olga Ivetic, Radosav Radosavkic

{"title":"Depressive symptoms delayed but subsequently led to the diagnosis of transthyretin amyloidosis: a case report.","authors":"Vladimir Knezevic, Dragana Ratkovic, Zeljko Zivanovic, Masa Comic, Jelena Knezevic, Olga Ivetic, Radosav Radosavkic","doi":"10.1177/03000605251318000","DOIUrl":"10.1177/03000605251318000","url":null,"abstract":"Transthyretin amyloidosis is a rare disorder caused by the accumulation of misfolded transthyretin amyloid in organs. The symptoms can include neuropathy, cardiomyopathy, nephropathy, depression and cognitive decline. Because of the non-specificity of symptoms, it usually takes considerable time to diagnose, which delays specific therapy and leads to a worse prognosis. Our case highlights the psychological symptoms of this disorder that initially delayed diagnosis, and later helped to reach the correct diagnosis. We report the case of a man who presented with weakness of limbs, dizziness, vomiting, social withdrawal, loss of interest, reduced energy and difficulty concentrating. Different specialist evaluations failed to identify a cause, and the symptoms were attributed to depressive disorder. After psychiatric hospitalization to rule out depression as a possible cause, the patient was transferred to an internal medicine clinic where additional diagnostics led to a transthyretin amyloidosis diagnosis. Early-stage transthyretin amyloidosis is difficult to diagnose owing to its non-specific symptoms, but timely treatment is necessary to improve the disease course and outcome. With reference to this case, we emphasize that psychological symptoms in somatic illnesses can both delay and facilitate diagnosis of underlying disease.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251318000"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and pathological characteristics of pulmonary meningioma: a case report and literature review.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605241293675

Hui-Fang Chang, Nuerdong Maimaitiaili, Jun-Feng Huo, Zhu-Lei Sun

{"title":"Clinical and pathological characteristics of pulmonary meningioma: a case report and literature review.","authors":"Hui-Fang Chang, Nuerdong Maimaitiaili, Jun-Feng Huo, Zhu-Lei Sun","doi":"10.1177/03000605241293675","DOIUrl":"10.1177/03000605241293675","url":null,"abstract":"This case report aimed to examine the clinical pathological characteristics, immunohistochemical phenotype, and differential diagnosis of primary pulmonary meningioma (PM), which is a rare tumor. A retrospective analysis was conducted on the clinical data, imaging manifestations, histological features, immunohistochemical results, and in situ hybridization results of a 60-year-old male patient who underwent surgical resection and was diagnosed with PM by pathology. Additionally, the relevant literature was reviewed. Multiple nodules were detected in the right lung of the patient during a re-examination because of a novel coronavirus infection but there were no obvious clinical symptoms. Imaging revealed well-defined masses in the upper, middle, and lower lobes of the right lung, and the masses were surgically removed. Microscopy showed that the boundary between the tumor and surrounding lung tissue was clear, and consisted of spindle cells and epithelioid cells. The final diagnosis was multiple grade II meningiomas of the right lung. No postoperative radiotherapy or chemotherapy was performed. There was no recurrence or metastasis during a 6-month follow-up. Pulmonary metastatic meningioma is rare, while primary PM is even rarer. Surgical resection is the preferred treatment method for PM, with a generally good prognosis, but a few malignant manifestations may require close follow-up.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605241293675"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of angiotensin-converting enzyme (ACE), ACE2, and their genetic polymorphisms in patients with acute aortic dissection and coronary heart disease.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251322355

Yang Li, Zongwei Xiao

{"title":"Analysis of angiotensin-converting enzyme (ACE), ACE2, and their genetic polymorphisms in patients with acute aortic dissection and coronary heart disease.","authors":"Yang Li, Zongwei Xiao","doi":"10.1177/03000605251322355","DOIUrl":"10.1177/03000605251322355","url":null,"abstract":"Background: This study aimed to elucidate the distinctions between the expression levels of angiotensin-converting enzyme (ACE) and ACE2, as well as their genetic polymorphisms, in patients with acute aortic dissection (AD) and coronary heart disease (CHD).Methods: A cohort of 86 patients was enrolled, comprising 34 individuals with acute AD (encompassing Stanford types A and B), 18 with ascending aortic aneurysm, 21 with CHD, and 13 healthy controls. Aortic tissue samples were procured from 44 patients during surgical interventions.Results: Statistically significant differences were observed in ACE and ACE2 expression levels among the ascending aortic aneurysm, CHD, and control groups (p < 0.05). However, the expression of ACE messenger ribonucleic acid (mRNA) in the aortic wall was significantly higher in the AD group than in the ascending aortic aneurysm and CHD groups (p < 0.05). Additionally, the expression of ACE2 mRNA and the ACE/ACE2 ratio in the aortic wall were significantly different in the AD group compared with the ascending aortic aneurysm and CHD groups (p < 0.05).Conclusion: Plasma ACE levels, and the gene expressions of ACE and ACE2, are markedly reduced in patients with acute AD. The observed imbalance in ACE and ACE2 expressions may play a pivotal role in the pathogenesis of AD.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251322355"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating type IV collagen 7S concentrations are associated with left atrial remodeling indices in patients with atrial fibrillation.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251314832

Yuki Kuzume, Kosuke Fujibayashi, Kai Tanaka, Jun Sawaguchi, Ei-Ichi Ueno, Nakaba Fujioka, Yasuyuki Kawai, Kouji Kajinami

{"title":"Circulating type IV collagen 7S concentrations are associated with left atrial remodeling indices in patients with atrial fibrillation.","authors":"Yuki Kuzume, Kosuke Fujibayashi, Kai Tanaka, Jun Sawaguchi, Ei-Ichi Ueno, Nakaba Fujioka, Yasuyuki Kawai, Kouji Kajinami","doi":"10.1177/03000605251314832","DOIUrl":"10.1177/03000605251314832","url":null,"abstract":"Objective: Non-alcoholic fatty liver disease is a risk factor for atrial fibrillation. We assessed whether liver fibrosis markers are associated with atrial remodeling indicators in patients with atrial fibrillation in whom fatty liver disease has not been identified.Methods: In this prospective, observational study, 174 patients with atrial fibrillation without chronic liver disease who underwent catheter ablation were enrolled. Using blood collected from the right atrium, type IV collagen (COL4), type IV collagen 7S (COL4-7S), and tumor necrosis factor-α concentrations were measured as markers of liver fibrosis and inflammation. The left atrial volume and P-wave duration were used as atrial remodeling indicators.Results: Left atrial volume was significantly positively correlated with COL4, COL4-7S, and tumor necrosis factor-α concentrations. COL4-7S concentrations were significantly positively correlated with tumor necrosis factor-α concentrations and the P-wave duration. To exclude the effect of alcohol consumption, a multiple regression analysis was performed for left atrial volume in patients with a <30-g daily alcohol intake (n = 124). Age, sex, and COL4-7S were significant explanatory variables (R = 0.44, adjusted R2 = 0.142, COL4-7S standardized β = 0.20).Conclusion: Liver fibrosis may be involved in atrial remodeling via inflammation in patients with atrial fibrillation who do not have obvious fatty liver disease.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251314832"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat stroke with sepsis: A case report and review of the literature.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315353

Suyu Wei, Liang Sun

引用次数: 0

Thanks to Reviewers.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251323956

引用次数: 0