Journal of International Medical Research最新文献_第5页

Causal association between glaucoma and risk of retinal vascular occlusion: a Mendelian randomization study. 青光眼与视网膜血管闭塞风险的因果关系：一项孟德尔随机研究。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241286985

Zixun Wang, Kaihua Xu, Xiaoling Zhang, Ruihua Wei, Zhiqing Li

{"title":"Causal association between glaucoma and risk of retinal vascular occlusion: a Mendelian randomization study.","authors":"Zixun Wang, Kaihua Xu, Xiaoling Zhang, Ruihua Wei, Zhiqing Li","doi":"10.1177/03000605241286985","DOIUrl":"10.1177/03000605241286985","url":null,"abstract":"Objective: Retinal vein occlusion (RVO) leads to visual impairment, and risk factors may include glaucoma. Although some studies suggest a relationship between glaucoma and RVO, it is unknown whether this association is causal. We performed Mendelian randomization (MR) analyses to evaluate the causal contribution to RVO of five genetically predicted glaucoma conditions.Methods: We conducted two-sample univariable MR analysis using inverse variance weighting, weighted median, and MR-Egger methods. We obtained publicly available datasets of genome-wide association studies (GWAS) meta-analyses for glaucoma as the exposure and a GWAS for RVO in the Finn Gen biobank study as the outcome.Results: Genetically predicted glaucoma was causally associated with RVO risk (beta = 0.267, standard error [SE] = 0.052, odds ratio [OR] = 1.306, 95% confidence interval [CI]: 1.181-1.445). This association was supported by sensitivity analyses using weighted median (beta = 0.211, SE = 0.075, OR = 1.235, 95% CI: 1.067-1.429), weighted mode (beta = 0.491, SE = 0.132, OR = 1.633, 95% CI: 1.261-2.116), and MR-Egger (beta = 0.3900, SE = 0.138, OR = 1.476, 95% CI: 1.128-1.933) methods. MR analyses using the validation dataset obtained consistent results.Conclusion: Our results indicated that glaucoma is likely causally associated with an increased risk of RVO. The current findings may help in determining the underlying mechanisms via which glaucoma affects the risk of RVO.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241286985"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heavily treatment-experienced patients with HIV: are new mechanisms of action enough? 接受过大量治疗的艾滋病患者：新的作用机制是否足够？

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241301883

Marisa B Brizzi, Tracy L Cable, Dimple C Patel, Kelli Williams, Zoe Adjei, Carl J Fichtenbaum

引用次数: 0

Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults. 中国成人狼疮肾炎患者白细胞计数与肾功能关系的回顾性研究。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241305433

Jianyu Chen, Rong Cao, Jianying Guo, Yang Liu, Haofei Hu, Qijun Wan

{"title":"Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults.","authors":"Jianyu Chen, Rong Cao, Jianying Guo, Yang Liu, Haofei Hu, Qijun Wan","doi":"10.1177/03000605241305433","DOIUrl":"10.1177/03000605241305433","url":null,"abstract":"Objective: To explore the relationship between leukocyte count and renal function in patients with lupus nephritis (LN).Methods: We performed a retrospective cross-sectional study of 100 patients with LN admitted to the Department of Nephrology between 1 January 2015 and 30 December 2023. Based on tertile of leukocyte count, they were allocated to Low, Medium, or High groups. The demographic, clinical, and pathologic characteristics of the groups were compared and the relationship between leukocyte count and renal function was analyzed using multiple linear regression analysis.Results: After adjustment for age, albumin, 24-hour proteinuria, serum complement factor 3, hemoglobin, blood pressure, systemic lupus erythematosus disease activity index score, and histologic parameters, a linear relationship was identified between leukocyte count and renal function (regression coefficient -2.852; 95% confidence interval: -5.161, -0.543). Therefore, for every 1 × 109/L increase in leukocyte count, the estimated glomerular filtration rate would decrease by 2.85 mL/minute.Conclusion: There is an independent linear relationship between leukocyte count and renal function. Leukocyte recruitment into the kidney is a critical step in the progression of LN, and as the leukocyte count increases, renal function gradually declines. Leukocyte count may represent a sensitive biomarker of the progression and prognosis of LN.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241305433"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the epidemiological burden of RSV pre- and post-COVID-19 pandemic: A Jordanian tertiary hospital experience. 探索RSV covid -19大流行前后的流行病学负担：约旦三级医院的经验

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241306405

Enas Al-Zayadneh, Dana Marie, Farah A Khraisat, Suzan S Musa, Jehad Feras AlSamhori, Dina Alkhateeb Altamimi, Alia O Khashman, Amirah Daher, Montaha Al-Iede

{"title":"Exploring the epidemiological burden of RSV pre- and post-COVID-19 pandemic: A Jordanian tertiary hospital experience.","authors":"Enas Al-Zayadneh, Dana Marie, Farah A Khraisat, Suzan S Musa, Jehad Feras AlSamhori, Dina Alkhateeb Altamimi, Alia O Khashman, Amirah Daher, Montaha Al-Iede","doi":"10.1177/03000605241306405","DOIUrl":"10.1177/03000605241306405","url":null,"abstract":"Objectives: To describe changes in respiratory syncytial virus (RSV) epidemiology, its associated clinical outcomes and predictors of severe acute lower respiratory tract infection (ALRTI) pre- and post-COVID-19.Methods: In this retrospective cohort, we analysed data from electronic medical record of children <5 years who were hospitalized at Jordan University Hospital with RSV-associated ALRTI from 2018 to 2022.Results: 325 inpatients with respiratory infections were included. Rate of RSV infections decreased from 74% pre-pandemic to 30% post-pandemic. Patients diagnosed with ALRTI post-COVID had significantly higher SpO2, less chronic disease, lower temperature and respiratory rate at admission and fewer days in hospital compared with those diagnosed pre-COVID. Furthermore, patients diagnosed pre-pandemic were significantly more likely to have abnormal X-rays, used more antibiotics and antivirals, and had higher rates of severe disease than those with infection post-COVID.Conclusion: COVID-19 and its associated social restriction measures led to changes in RSV epidemiology, characterized by a decline in rates and clinical severity in the post-pandemic period. However, further studies are needed to characterize the impact of COVID-19 on subsequent RSV seasons.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241306405"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of low-power versus high-power holmium laser enucleation of the prostate for symptomatic small-volume benign prostatic hyperplasia: a prospective randomized controlled trial. 低功率与高功率钬激光前列腺摘除治疗症状性小体积良性前列腺增生的比较分析：一项前瞻性随机对照试验。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241304542

Zhixiang Gao, Yue Ding, Haiyong Liu, Renji Du, Zhiwei Sun, Li Xu, Lijuan Gu, Ping Wang, Rong Wang

{"title":"Comparative analysis of low-power versus high-power holmium laser enucleation of the prostate for symptomatic small-volume benign prostatic hyperplasia: a prospective randomized controlled trial.","authors":"Zhixiang Gao, Yue Ding, Haiyong Liu, Renji Du, Zhiwei Sun, Li Xu, Lijuan Gu, Ping Wang, Rong Wang","doi":"10.1177/03000605241304542","DOIUrl":"10.1177/03000605241304542","url":null,"abstract":"Objective: To compare the safety and efficacy of low-power (LP) and high-power (HP) holmium laser enucleation of the prostate (HoLEP) in patients with symptomatic small-volume benign prostatic hyperplasia (BPH).Methods: In this prospective, multicenter, single-blind, randomized controlled trial, men with symptomatic BPH (prostate volume <40 mL, peak urinary flow rate [Qmax] <10 mL/s, International Prostate Symptom Score [IPSS] ≥18) underwent either LP (24 W) or HP HoLEP (80 W). The primary outcome was IPSS at 6 months postoperatively. Secondary outcomes included the surgical duration, total laser energy, enucleated prostate weight, patient-reported outcomes, and Clavien-Dindo classification of complications at 1, 3, and 6 months after surgery.Results: Eighty-one participants completed the study. LP HoLEP used significantly less energy (22.4 ± 10.4 kJ vs. 58.6 ± 17.8 kJ). Postoperative pain was lower in the LP group at 24 and 48 hours. Both groups displayed significant improvements in outcomes versus baseline including IPSS and Qmax. The incidence of intraoperative complications was similar, though minor capsular perforation occurred exclusively in the HP group (9.8%).Conclusion: LP HoLEP produced comparable clinical outcomes as HP HoLEP for small-volume BPH while using less energy, supporting its use for smaller glands.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241304542"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Success rate of acceleromyographic neuromuscular monitoring based on the depth of anesthesia at the time of sugammadex antagonism: a randomized controlled trial. 糖玛德拮抗时基于麻醉深度的加速肌图神经肌肉监测的成功率：一项随机对照试验。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241305474

Hwang-Ju You, Seok-Jin Lee, Ji-Yoon Jung, Sung-Ae Cho, Woojin Kwon, Jin-Bum Kim, Tae-Yun Sung

{"title":"Success rate of acceleromyographic neuromuscular monitoring based on the depth of anesthesia at the time of sugammadex antagonism: a randomized controlled trial.","authors":"Hwang-Ju You, Seok-Jin Lee, Ji-Yoon Jung, Sung-Ae Cho, Woojin Kwon, Jin-Bum Kim, Tae-Yun Sung","doi":"10.1177/03000605241305474","DOIUrl":"10.1177/03000605241305474","url":null,"abstract":"Objective: We aimed to compare the success of non-normalized acceleromyographic neuromuscular monitoring and recovery profiles based on the depth of anesthesia at the time of sugammadex administration.Methods: Patients undergoing general anesthesia were prospectively and randomly allocated to two groups. In the BIS60 group, sugammadex was administered when there was a bispectral index (BIS) <60 and anesthesia was maintained until a train-of-four ratio ≥1.0 was obtained, whereas in the BIS70 group, anesthesia was stopped at the completion of surgery, sugammadex was administered when the BIS was >70, and the recovery of neuromuscular function was monitored. The recovery profile and the incidence of emergence agitation of the two groups were compared.Results: The success rate of neuromuscular monitoring was significantly higher for the BIS60 group than for the BIS70 group (100% vs. 37.5%, respectively). The time taken for recovery for the two groups was comparable. The incidence of emergence agitation was significantly lower in the BIS60 group than in the BIS70 group (23.3% vs. 56.3%, respectively).Conclusion: After the administration of sugammadex, the maintenance of anesthesia until the full recovery of neuromuscular function increases the success rate of neuromuscular monitoring without delaying recovery and reduces the risk of emergence agitation.Clinical trial registration: CRIS registration number KCT0007899 (https://cris.nih.go.kr/).","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241305474"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of asymptomatic peptic ulcer disease diagnosed during screening endoscopy in patients with cirrhosis. 肝硬化患者内镜筛查诊断无症状性消化性溃疡的流行病学。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241305258

Girma Deshimo Lema, Enguday Demeke Gebeyaw

{"title":"Epidemiology of asymptomatic peptic ulcer disease diagnosed during screening endoscopy in patients with cirrhosis.","authors":"Girma Deshimo Lema, Enguday Demeke Gebeyaw","doi":"10.1177/03000605241305258","DOIUrl":"10.1177/03000605241305258","url":null,"abstract":"Objective: Asymptomatic peptic ulcer disease (PUD) is frequently overlooked in patients with cirrhosis, who are at increased risk for gastrointestinal complications that can lead to increased morbidity and mortality. We aimed to determine the prevalence and associated factors of asymptomatic PUD identified during screening endoscopy in patients with cirrhosis.Methods: We conducted a retrospective cross-sectional study among patients with cirrhosis at St. Paul's Hospital Millennium Medical College in Ethiopia. Data were collected using a structured questionnaire from patients' medical charts. A logistic regression model was used to identify predictors of peptic ulcer.Results: This study included 296 patients, revealing that 19.6% had PUD (95% confidence interval: 13.5-26.4). Significant associations were found between peptic ulcer and Helicobacter pylori infection, moderate and heavy alcohol consumption, and Child-Pugh class C cirrhosis.Conclusion: We found that patients with liver cirrhosis are more likely to have asymptomatic peptic ulcers. Asymptomatic PUD was linked to H. pylori infection, greater alcohol consumption, and Child-Pugh class C liver disease, highlighting the need for targeted prevention and management strategies to reduce morbidity in patients with cirrhosis, such as eradication therapy for H. pylori and counseling on alcohol use.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241305258"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenoid cystic carcinoma in the nasolacrimal duct: a case report. 鼻泪管腺样囊性癌1例。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241310843

Seung-Myoung Son, Chang Gok Woo

引用次数: 0

Characteristics and outcomes of patients with Guillain-Barré syndrome who were admitted to the intensive care unit: a retrospective observational study. 入住重症监护室的格林-巴罗综合征患者的特征和结局：一项回顾性观察性研究。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241306655

Samah Alqahtani, Hasan M Al-Dorzi, Hatim Arishi, Ahmad Peeran, Felwa Bin Humaid, Farhan Zayed Alenezi, Jesna Jose, Musharaf Sadat, Naser Alotaibi, Yaseen M Arabi

{"title":"Characteristics and outcomes of patients with Guillain-Barré syndrome who were admitted to the intensive care unit: a retrospective observational study.","authors":"Samah Alqahtani, Hasan M Al-Dorzi, Hatim Arishi, Ahmad Peeran, Felwa Bin Humaid, Farhan Zayed Alenezi, Jesna Jose, Musharaf Sadat, Naser Alotaibi, Yaseen M Arabi","doi":"10.1177/03000605241306655","DOIUrl":"10.1177/03000605241306655","url":null,"abstract":"Objective: To evaluate characteristics and outcomes in critically ill patients with Guillain-Barré syndrome (GBS).Methods: Consecutive adults with GBS who required intensive care unit (ICU) admission at a tertiary-care hospital between 1999 and 2020 were enrolled into this retrospective cohort study. Demographics, clinical data and patient outcomes were compared between patients who did or did not receive mechanical ventilation (MV).Results: During the study period, the number of ICU admissions gradually rose from approximately 900 to 3000 annually. Forty-three patients had GBS and were included, of whom, 27 (62.8%) received MV for a median of 13 days. The MV group stayed longer in the ICU (median, 26 versus 6 days) and in the hospital (median, 120 versus 39 days) than the non-MV group. Most patients in the MV group (22 [81.5%]) required tracheostomy. At maximum follow-up, Hughes Functional Grading scores were 0 (full recovery) in 11 patients (25.5%), 1-3 in 18 (41.8%), 4-5 in 12 (27.9%), and 6 (death) in two (4.6%, both in the MV group), with higher median Hughes score in the MV group (3 versus 0.5). Complications during ICU and hospital stay included: veinous thromboembolism in five (11.6%), gastrointestinal bleeding in three (7.0%), bacteremia in five (11.6%), bedsore in one (2.3%), and GBS-treatment side effects in four (9.4%) patients; all of these complications occurred within the MV group.Conclusions: GBS was an uncommon reason for ICU admission. The findings highlight significant morbidity with GBS, particularly among patients who need MV.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241306655"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haematometra arising from multiple abortions: a comprehensive case report. 多胎流产致血肿一例综合报道。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241304576

Georges Yared, Ali Younis, Khodor Al Hajj, Charlotte El Hajjar, Wardah Alakrah, Hamza Nakib, Christopher Massaad, Kariman Ghazal

引用次数: 0