Journal of International Medical Research最新文献

{"title":"Mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 deficiency with severe hyperglycemia in a child: A rare case report.","authors":"Chang Dong, Tiantian Lu, Yazhou Jiang, Zihao Yan, Suyue Zhu","doi":"10.1177/03000605251375537","DOIUrl":"10.1177/03000605251375537","url":null,"abstract":"<p><p>Mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 (HMGCS2) deficiency is an exceptionally rare autosomal recessive metabolic disorder that impairs ketogenesis. It is typically characterized by hypoketotic hypoglycemia during periods of fasting or metabolic stress. Notably, severe hyperglycemia as an initial presenting symptom has not been previously reported. We report the case of a 6-month-old girl who suddenly developed coma after 1 day of fasting due to repeated vomiting during pneumonia. At presentation, she had hyperglycemia (25.8 mmol/L), ketonuria (1+), glucosuria (3+), metabolic acidosis (pH 6.90), elevated serum alanine transaminase and aspartate aminotransferase levels, increased blood ammonia levels, and liver enlargement on ultrasound. However, fasting insulin, glucagon, and glycated hemoglobin levels were all within the normal range. Whole-exome sequencing identified compound heterozygous mutations in the HMGCS2 gene-c.1175C>T (p.S392L) inherited from the father and c.719A>T (p.A240V) inherited from the mother-thereby confirming the diagnosis of HMGCS2 deficiency. This case highlights severe hyperglycemia as an atypical clinical feature of HMGCS2 deficiency. Increased awareness of such rare manifestations may assist in improving early diagnosis and treatment of this condition.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375537"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prechemoradiotherapy number of natural teeth as a prognostic factor in patients with locally advanced nasopharyngeal cancer: A retrospective observational study.","authors":"Erkan Topkan, Efsun Somay, Sibel Bascil, Duriye Ozturk, Ugur Selek","doi":"10.1177/03000605251379977","DOIUrl":"10.1177/03000605251379977","url":null,"abstract":"<p><p>ObjectiveThis study evaluated the prognostic value of the pretreatment number of natural teeth on progression-free survival and overall survival in patients with locally advanced nasopharyngeal carcinoma treated with concurrent chemoradiotherapy.MethodsWe retrospectively analyzed 248 patients with locally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy-based concurrent chemoradiotherapy and adjuvant chemotherapy between June 2010 and December 2021. The number of natural teeth was assessed before concurrent chemoradiotherapy. A receiver operating characteristic curve analysis was performed to identify the optimal number of natural teeth threshold predictive of overall survival and progression-free survival.ResultsThe optimal cutoff value for the number of natural teeth was 19.5 (area under the curve: 70.6%). Patients were grouped into those with a number of natural teeth <20 (<i>n</i> = 76) and those with a number of natural teeth ≥20 (<i>n</i> = 172). The number of natural teeth ≥20 group had significantly improved overall survival (not reached vs. 71.0 months; p < 0.001) and progression-free survival (117 vs. 38.0 months; p < 0.001). Multivariate analysis confirmed the number of natural teeth <20 as an independent predictor of worse outcomes.ConclusionsA pretreatment number of natural teeth <20 independently predicts poorer survival in patients with locally advanced nasopharyngeal carcinoma receiving concurrent chemoradiotherapy, suggesting that the number of natural teeth may serve as a simple, accessible prognostic biomarker in head and neck oncology.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379977"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between neutrophil-to-lymphocyte ratio, red blood cell distribution width, platelet distribution width, and colorectal adenoma: A retrospective cohort study.","authors":"Runhan Liu, Fanglai Zhu","doi":"10.1177/03000605251379263","DOIUrl":"10.1177/03000605251379263","url":null,"abstract":"<p><p>ObjectiveThe objective of this study was to explore correlations between red blood cell distribution width, neutrophil-to-lymphocyte ratio, platelet distribution width, and colorectal adenomas.MethodsRetrospective analysis of 120 patients undergoing colonoscopy (from January to December 2024) divided into adenoma (n = 60) and control (n = 60) groups. Demographic characteristics, habits, and blood parameters were compared.ResultsSignificant differences in neutrophil-to-lymphocyte ratio, platelet distribution width, and red blood cell distribution width between groups (P < 0.05) were noted. Spearman analysis showed positive correlations: neutrophil-to-lymphocyte ratio and platelet distribution width (r = 0.434), neutrophil-to-lymphocyte ratio and red blood cell distribution width (r = 0.461), and red blood cell distribution width and platelet distribution width (r = 0.424) (P < 0.001). Logistic regression identified neutrophil-to-lymphocyte ratio (odds ratio = 5.027), platelet distribution width (odds ratio = 1.553), and red blood cell distribution width (odds ratio = 9.081) as independent risks.ConclusionElevated neutrophil-to-lymphocyte ratio, platelet distribution width, and red blood cell distribution width are independent risk factors. Early colonoscopy and intervention may serve as non-invasive biomarkers for early screening.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379263"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study.","authors":"Tao Zhang, Ya Zhou, Long-Fei Luo, Deng-Jun Ji, Liang Wang, Jun Xie, An-Ning Zhu, Jun-Tao Yan, Zhen Yan, Li Gong, Wu-Quan Sun","doi":"10.1177/03000605251367610","DOIUrl":"10.1177/03000605251367610","url":null,"abstract":"<p><p>ObjectiveSarcopenia poses a significant global public health burden, underscoring the urgency of identifying reliable risk markers for early detection and intervention. This study aimed to elucidate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia as well as explore how various covariates modify this relationship.MethodsA cross-sectional analysis was performed using data from 9040 individuals who participated in the National Health and Nutrition Examination Survey 2011-2018, of whom 721 were diagnosed with sarcopenia. Multivariable logistic regression models were employed to estimate the odds ratios and 95% confidence intervals for the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Restricted cubic spline regression analysis was utilized to assess the nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk. Subgroup analysis was performed to identify the relationship between different subgroups of neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Considering the conflict between the lower age threshold and the diagnostic criteria for sarcopenia, we conducted sensitivity analysis among participants aged ≥40 years.ResultsMultivariable logistic regression analysis revealed that the neutrophil-to-high-density lipoprotein cholesterol ratio was positively associated with sarcopenia risk (odds ratio = 1.16, 95% confidence interval: 1.11-1.22, <i>P </i><<i> </i>0.0001). Restricted cubic spline regression analysis demonstrated a nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (nonlinear <i>P </i><<i> </i>0.05). Subgroup analyses indicated that sex, race, and hyperlipidemia significantly modified the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (<i>P</i> for interaction <0.05).ConclusionsAn elevated neutrophil-to-high-density lipoprotein cholesterol ratio is associated with a high risk of sarcopenia, indicating that the ratio can effectively assess the risk of sarcopenia and may contribute to early diagnosis and preventive intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251367610"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parvovirus B19-induced aplastic anemia following mechanical valve replacement.","authors":"Xiantao Ma, Ningxin Hou, Chenhe Li, Yi Feng, Xiaoxue Zhang, Shiliang Li, Cai Cheng","doi":"10.1177/03000605251377626","DOIUrl":"10.1177/03000605251377626","url":null,"abstract":"<p><p>Human parvovirus B19 infection in immunocompetent adults predominantly manifests as arthropathy or erythema infectiosum, with transient aplastic crisis being a rare hematological complication. We report a diagnostically challenging case of a man in his late 40s who developed recurrent severe aplastic anemia following mechanical valve replacement. Notably, the patient presented with progressive pancytopenia despite optimal anticoagulation and normally functioning prosthetic valves on serial echocardiograms. Critical diagnostic differentiation was achieved through comprehensive laboratory evaluation; elevated lactate dehydrogenase (232.00 U/L) and undetectable haptoglobin levels initially suggested mechanical hemolysis. However, suppressed reticulocyte production index (0.002) and the presence of human parvovirus B19 (DNA) confirmed virus-mediated marrow suppression. The absence of schistocytes on peripheral smear and stable hemoglobinuria levels further excluded prosthetic valve-related hemolysis. To the best of our knowledge, this study represents the first documented case of human parvovirus B19-induced aplastic anemia in a postcardiotomy patient with confirmed valve competence, highlighting three key clinical imperatives: 1. Human parvovirus B19 should be included in the differential diagnosis of postoperative pancytopenia regardless of immune status; 2. disproportionate reticulocytopenia with normal hemolysis markers may indicate viral marrow infiltration; and 3. serial echocardiographic surveillance cannot fully exclude subclinical hemolysis, necessitating multimodal laboratory correlation.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251377626"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum histamine in non-small cell lung cancer: An observational study in the context of allergo-oncology.","authors":"Zhai Rongrong, Shu Wenyue, Hu Yanyun, Zhang Fengli, Sun Lei","doi":"10.1177/03000605251381195","DOIUrl":"10.1177/03000605251381195","url":null,"abstract":"<p><p>ObjectivesThe objective of this study was to assess serum histamine levels in patients with non-small cell lung cancer and investigate their association with tumor metastasis.MethodsA retrospective study was conducted at Lu'an Hospital between 2020 and 2024, including 90 patients (70 with non-small cell lung cancer and 20 with benign pulmonary nodules) selected from an initial cohort of 416 patients after applying strict inclusion and exclusion criteria. Serum histamine levels were measured, and other clinical characteristics and laboratory parameters were obtained directly from the electronic medical record system. Receiver operating characteristic curves were used to evaluate the diagnostic performance. Non-small cell lung cancer patients were stratified by metastatic status for group comparisons and logistic regression analyses.ResultsNon-small cell lung cancer patients had significantly higher serum histamine levels than those with benign nodules (median: 8.58 vs. 5.97 µg/L, p = 0.024). A cutoff of 7 µg/L yielded a sensitivity of 65.7% and a specificity of 65.0% for distinguishing non-small cell lung cancer, with an area under the curve of 0.666. Among non-small cell lung cancer patients, those with metastasis (<i>n</i> = 35) had higher histamine levels than nonmetastatic cases (median: 9.39 vs. 7.18 µg/L, p = 0.001). Complement C3 levels and the neutrophil-to-lymphocyte ratio were also higher in metastatic patients. Multivariable logistic regression analyses showed that serum histamine (odds ratio: 1.213, 95% confidence interval: 1.011-1.455, p = 0.038) and complement C3 (OR: 1.488, 95% CI: 1.104-2.004, p = 0.009) were independently associated with metastasis in non-small cell lung cancer patients.ConclusionsSerum histamine levels were elevated in non-small cell lung cancer patients and were independently associated with tumor metastasis. These findings provide preliminary evidence of a possible connection between histamine and the emerging field of allergo-oncology. Complement C3 was also found to be independently associated with metastasis. Further studies are warranted to validate these results and explore the underlying immunological mechanisms.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251381195"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cecal schwannoma: A case report and literature review.","authors":"Limin Xu, Xiaozhong Shi, Tong Huan, Shihui Huang","doi":"10.1177/03000605251379218","DOIUrl":"https://doi.org/10.1177/03000605251379218","url":null,"abstract":"<p><p>Schwannomas are slow-growing tumors originating from Schwann cells and are rarely found in the gastrointestinal tract, particularly in the cecum. We report the case of a 59-year-old man who had recurrent diarrhea and was found to have a mass in the cecum during endoscopic examination. Contrast-enhanced abdominal computed tomography revealed a slightly hypodense, homogeneous mass in the cecum with moderate enhancement. The tumor was laparoscopically resected. Histopathological examination indicated spindle-shaped tumor cells arranged in a fascicular or palisading pattern, with minimal cellular atypia and rare mitotic figures. Immunohistochemical staining was positive for S100 and SOX10. The final pathological diagnosis was schwannoma. The patient was followed up for 34 months postoperatively without recurrence or metastasis. Cecal schwannoma is a rare benign neoplasm. We present this case and review the clinical and imaging features of previously reported cases of cecal schwannoma to enhance diagnostic accuracy and improve clinicians' understanding of this uncommon tumor.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379218"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of targeted multilevel sleep surgery on resistant hypertension in patients with severe obstructive sleep apnea.","authors":"Ahmed Bahgat, Mostafa Elwany, Claudio Vicini, Yassin Bahgat, Giuseppe Magliulo, Antonio Greco, Armando De Virgilio, Annalisa Pace, Mario Giuseppe Bellizzi, Enrica Croce, Lodovica Gatti, Antonino Maniaci, Jerome R Lechien, Alberto Caranti, Stéphane Gargula, Luigi A Vaira, Heloisa Dos Santos, Giannicola Iannella","doi":"10.1177/03000605251361484","DOIUrl":"10.1177/03000605251361484","url":null,"abstract":"<p><p>ObjectiveObstructive sleep apnea is an independent risk factor for cardiovascular diseases, particularly resistant hypertension. For patients who are noncompliant or unable to tolerate continuous positive airway pressure therapy, surgical treatment may serve as a viable alternative. In this study, we evaluated the impact of multilevel sleep surgery on blood pressure levels in patients with resistant hypertension.MethodsThis is a bicentric retrospective observational study of 50 patients with severe obstructive sleep apnea and resistant hypertension who underwent multilevel targeted sleep surgery.ResultsClinical improvement was objectively confirmed by polygraphy performed 6 months after surgery, demonstrating a significant reduction in the mean Apnea-Hypopnea Index from 44.98 ± 14.94 to 22.16 ± 7.30 (<i>P</i> < 0.005). Furthermore, the adjusted mean preoperative systolic blood pressure decreased from 150 ± 14.77 to 124 ± 17.14 mmHg (<i>P</i> < 0.001), while diastolic blood pressure decreased from 94 ± 5.3 to 80 ± 7.2 mmHg (<i>P</i> < 0.001). Notably, 20 patients (40%) no longer required antihypertensive medication after surgery.DiscussionTo the best of our knowledge, this study is the first clinical trial to evaluate the efficacy of multilevel surgery in improving resistant systemic hypertension in patients with multilevel airway obstruction and severe obstructive sleep apnea syndrome.ConclusionsThis study highlights the potential of multilevel sleep surgery as an effective intervention for improving blood pressure control in patients with resistant hypertension and severe obstructive sleep apnea.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251361484"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the relationship between anthropometric indices and visceral adipose tissue: A cross-sectional study in a Qatari population.","authors":"Rawan Ajeen, Karam I Turk-Adawi, Alice S Ammerman, John A Batsis, Shu Wen Ng, Linda S Adair","doi":"10.1177/03000605251371603","DOIUrl":"10.1177/03000605251371603","url":null,"abstract":"<p><p>ObjectiveTo evaluate how body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio reflect visceral adipose tissue as measured by dual-energy X-ray absorptiometry and how these associations differ by sex and age in a Qatari adult population.MethodsIn this cross-sectional study of 5897 Qatari adults aged 18-88 years from the Qatar BioBank, we assessed the correlation between anthropometric indices and dual-energy X-ray absorptiometry-derived visceral adipose tissue percentage. Analyses included sex-stratified Spearman's correlations and linear regression models adjusted for age. Model performance was assessed using standardized beta coefficients, <i>R</i>², adjusted <i>R</i>², Akaike Information Criterion, and Bayesian Information Criterion.ResultsAmong females, waist circumference and waist-to-height ratio had the strongest correlations with visceral adipose tissue (<i>r</i> = 0.70), followed by waist-to-hip ratio (<i>r</i> = 0.68), whereas body mass index showed a moderate correlation with visceral adipose tissue (<i>r</i> = 0.54). Among males, waist-to-hip ratio showed the highest correlation with visceral adipose tissue (<i>r</i> = 0.71). Regression analyses confirmed waist-to-hip ratio as the strongest predictor in males and waist circumference as the strongest in females. Interaction models showed that associations between central adiposity indices and visceral adipose tissue strengthened with age.ConclusionAnthropometric indices reflecting central adiposity, waist-to-hip ratio, waist circumference, and waist-to-height ratio outperformed body mass index in predicting visceral adipose tissue in a sex- and age-specific manner. These findings may support the clinical utility of incorporating waist-based measures for visceral adipose tissue risk assessment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251371603"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A predictive model for evaluating the efficacy of immunotherapy in non-small-cell lung cancer patients: A real-world study.","authors":"Hai-Hong Yu, Jun-Quan Zeng, Jin-Hua Yuan, Bin Liu","doi":"10.1177/03000605251371278","DOIUrl":"10.1177/03000605251371278","url":null,"abstract":"<p><p>ObjectiveThe predictive accuracy of the efficacy of immunotherapy remains poor. Therefore, we aimed to develop a predictive model based on gene mutations to assess the immunotherapeutic efficacy in non-small-cell lung cancer.MethodsThree hundred and thirty-five non-small-cell lung cancer patients treated with immune checkpoint inhibitors were included in our study. The least absolute shrinkage and selection operator Cox regression model, multivariable analysis, and Kaplan-Meier test were used in this study.ResultsWe constructed a predictive model based on a 42-gene signature. Patients were classified into low-risk and high-risk groups based on risk scores generated from this model. Compared with patients in the high-risk group, those in the low-risk group showed better survival (median survival time: 36.0 vs. 6.0 months, <i>p </i><<i> </i>0.0001, unadjusted hazard ratio: 0.32, 95% confidence interval, 0.24-0.42). The results were confirmed in an external validation cohort. Moreover, patients with high tumor mutation burden in the high-risk group could not benefit from immune checkpoint inhibitors.ConclusionsA predictive model for evaluating the efficacy of immunotherapy was developed and validated. The model is based on multiple genetic information and has clinical translational value.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251371278"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}