Journal of International Medical Research最新文献

{"title":"The evidence for the use of peripheral blood indices in the diagnosis of breast cancer.","authors":"Zihan Zhou, Yu Zhou, Lin Liang, Biao Wang, Xiaolong Zhang, Yong Fu","doi":"10.1177/03000605261435744","DOIUrl":"10.1177/03000605261435744","url":null,"abstract":"<p><p>Diagnosis at early stages is critical for achieving favorable outcomes in patients with breast cancer. However, early breast cancer is characterized by atypical clinical and imaging manifestations, which are misdiagnosed as benign breast disease. This misdiagnosis may affect the choice of treatment, delay the patient's condition, and affect survival. Therefore, identifying an effective and simple screening method to supplement existing screening methods is of considerable importance for improving diagnostic efficacy. Peripheral blood indices are simple, economical, and readily accessible that include routine blood indices, lipid indices, and coagulation indices. With in-depth research on tumor pathogenesis, the relationships between these indices and tumor development have been gradually revealed, suggesting their potential as diagnostic factors for breast cancer. This narrative review explores the development of peripheral blood indices for diagnosing breast cancer and their potential use in early diagnosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261435744"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant transformation in a patient with type 1 neurofibromatosis: A case report.","authors":"Shengjie Li, Wenshuo Hao, Yingming Xue","doi":"10.1177/03000605261442415","DOIUrl":"10.1177/03000605261442415","url":null,"abstract":"<p><p>Neurofibromatosis is an autosomal dominant disease. The most common skin manifestation of type 1 neurofibromatosis is plexiform neurofibromas. Malignant peripheral nerve sheath tumors are rare and aggressive malignancies that predominantly arise from peripheral nerves and various nerve sheath cells. This report presents the case of a male patient in his late 50s who was diagnosed with malignant transformation of type 1 neurofibromatosis and treated surgically. The clinical manifestations, histopathological characteristics, treatment, and outcomes of this rare clinical case provide insights for subsequent diagnostic evaluation and clinical decision-making.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261442415"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of recurrence in patients with non-acute atherosclerotic middle cerebral artery occlusion: A longitudinal study using computed tomography perfusion and magnetic resonance imaging.","authors":"Xi Zhang, Yuxiang Zhang, Rongcheng Zou, He Zhang, Guangxin Duan, Zhibin Chen, Yun Luo, Jingwei Li","doi":"10.1177/03000605261443080","DOIUrl":"10.1177/03000605261443080","url":null,"abstract":"<p><p>ObjectiveThis study aimed to assess the performance of time to maximum concentration (Tmax) using computed tomography perfusion for predicting stroke recurrence in patients with symptomatic non-acute atherosclerotic middle cerebral artery occlusion.MethodsThis retrospective monocentric study enrolled 138 patients diagnosed with non-acute atherosclerotic middle cerebral artery occlusion. In addition to conventional computed tomography angiography or digital subtraction angiography, all patients underwent head computed tomography perfusion and magnetic resonance imaging 7-14 days after stroke and repeat head magnetic resonance imaging at 3-6 weeks. Volume of time to maximum concentration >4 s was considered the hypoperfusion area. The association between imaging characteristics, new ischemic lesion or lesion size increase on magnetic resonance imaging, and patient prognosis was assessed.ResultsIncreased number/area of infarct lesion was observed in 52/138 (37.7%) patients on diffusion weighted imaging 3-6 weeks after the first stroke. The volume of time to maximum concentration >4 s at baseline was strongly associated with infarct lesion development (odds ratio = 1.22 per 10-mL increase, 95% confidence interval: 1.10-1.34, <i>p</i> < 0.001). Volume of time to maximum concentration >4 s exhibited high discriminative ability for poor prognosis (area under the curve = 0.84, 95% confidence interval: 0.78-0.91, <i>p</i> < 0.001) with volume of time to maximum concentration >4 s larger than 99.8 mL being an optimal cutoff (odds ratio = 14.31, 95% confidence interval: 5.84-40.89, <i>p</i> < 0.001, sensitivity = 0.88 and specificity = 0.65).ConclusionsThe risk of stroke recurrence in patients with symptomatic non-acute atherosclerotic middle cerebral artery occlusion gradually increases with the volume of time to maximum concentration >4 s. Patients with volume of time to maximum concentration >4 s larger than 99.8 mL may have a significantly higher risk of stroke. Volume of time to maximum concentration >4 s on computed tomography perfusion can be used to predict the prognosis in patients with symptomatic non-acute atherosclerotic middle cerebral artery occlusion.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261443080"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated intraoperative strategies to prevent anastomotic leakage after laparoscopic low anterior resection: The roles of left colic artery preservation, reinforcement suturing, and transanal tube placement.","authors":"Chunxiao Lie, Shanshan Qian, Zhaocheng Chi","doi":"10.1177/03000605261434385","DOIUrl":"10.1177/03000605261434385","url":null,"abstract":"<p><p>Anastomotic leakage is a major complication following laparoscopic low anterior resection in patients with low rectal cancer. This study investigated the preventive effects of three intraoperative techniques, including the preservation of the left colic artery, reinforcement suturing, and transanal decompression tube placement. A total of 88 patients undergoing laparoscopic rectal cancer surgery were retrospectively analyzed. Univariate and multivariate logistic regression analyses were performed to assess the associations between these interventions and the occurrence of anastomotic leakage. The overall anastomotic leakage rate was 7.95%. Left colic artery preservation, reinforcement suturing, and transanal decompression tube placement each showed a lower anastomotic leakage incidence (5.3%, 6.3%, and 7.4%, respectively) compared with nonapplication. The combined use of all three measures resulted in zero anastomotic leakage. Multivariate analysis confirmed a consistent protective trend, with left colic artery preservation demonstrating the strongest effect. Preserving the left colic artery, reinforcing the anastomosis, and reducing intraluminal pressure act synergistically to reduce the risk of anastomotic leakage. Their integrated use may offer an effective strategy to enhance anastomotic safety in rectal surgery.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261434385"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatosensory evoked potential monitoring for position-related brachial plexus injury during cerebellopontine angle tumor resection: A retrospective cohort study.","authors":"Xian Jiang, Yanyi Yin, Xiaomin Hou, Jun Liu, Peng Li","doi":"10.1177/03000605261436656","DOIUrl":"10.1177/03000605261436656","url":null,"abstract":"<p><p>ObjectiveTo evaluate the utility of intraoperative somatosensory evoked potential monitoring for detecting position-related brachial plexus injury during cerebellopontine angle tumor resection, identify independent risk factors, and assess the effectiveness of somatosensory evoked potential-guided interventions.MethodsThis retrospective cohort study included 45 patients who underwent cerebellopontine angle microsurgery in the lateral or semilateral position. Median nerve somatosensory evoked potentials were continuously monitored. Patients were stratified according to somatosensory evoked potential changes. Clinical characteristics, surgical variables, and protective positioning measures were compared. Cox regression was performed to identify independent risk factors.ResultsSomatosensory evoked potential alterations occurred in 14 patients (31.1%). Following repositioning, 13 patients recovered intraoperatively; 9 patients returned to baseline within 46-110 min (mean, 64 ± 20.5 min) and 4 patients within 2 h. Changes in latency and threshold across time points were statistically significant (p<i> </i><<i> </i>0.01 and p<i> </i><<i> </i>0.0001, respectively). One patient without somatosensory evoked potential recovery developed mild, transient symptoms that resolved within 5 weeks. Independent risk factors included age ≥60 years (hazard ration = 2.78), body mass index ≥25 kg/m² (hazard ration = 3.02), operative time ≥5 h (hazard ration = 3.65), intraoperative temperature <36.5°C (hazard ration = 2.31), and absence of protective positioning (hazard ration = 3.87) (all p<i> </i><<i> </i>0.05).ConclusionsOur findings suggest that routine somatosensory evoked potential monitoring during lateral decubitus cerebellopontine angle tumor resection may help mitigate brachial plexus injury and improve surgical safety.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261436656"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between A Body Shape Index and sleep disorders among the U.S. population: A cross-sectional analysis of the National Health and Nutrition Examination Survey data.","authors":"Anhao Liu, Yuanqing Li, Xuehui Zhang, Ningkang Lv, Hong Lian Yang, Cuiping Hao, Dongmei Wu","doi":"10.1177/03000605261436605","DOIUrl":"10.1177/03000605261436605","url":null,"abstract":"<p><p>BackgroundAccumulating evidence suggests that sleep disorders are strongly associated with obesity, particularly visceral adiposity. A Body Shape Index has been recognized as a more accurate anthropometric indicator for assessing overall obesity and visceral fat levels. This study aimed to explore the potential relationship between obesity and sleep disorders in a representative sample of the U.S. adult population.MethodsThis retrospective study involved data from 25,057 adults aged 20 years and older who participated in the National Health and Nutrition Examination Survey between 2005 and 2016. Multivariate logistic regression models, restricted cubic spline analysis, and subgroup stratification were used to analyze the association between A Body Shape Index and sleep disorders.ResultsAmong the 25,057 participants, 6310 reported experiencing sleep disorders. After adjusting for potential confounders, the results revealed that a unit increase in A Body Shape Index was associated with a 10% higher likelihood of sleep disorders (odds ratio = 1.1, 95% confidence interval: 1.02-1.18, p<i> </i><<i> </i>0.05). When A Body Shape Index was categorized into tertiles, individuals in the highest tertile exhibited a significantly higher prevalence of sleep disorders compared with those in the lowest tertile (odds ratio = 1.13, 95% confidence interval: 1.04-1.23, p <<i> </i>0.05). Restricted cubic spline analysis revealed a nonlinear relationship between A Body Shape Index and sleep disorders (p<i> </i>=<i> </i>0.004). Additionally, subgroup analysis demonstrated a statistically significant interaction between age and A Body Shape Index categories (p<i> </i><<i> </i>0.05).ConclusionThese findings demonstrate a positive association between A Body Shape Index and the prevalence of sleep disorders. A Body Shape Index may serve as a practical and simple anthropometric marker for identifying individuals at increased risk of sleep disorders.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261436605"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13080157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-specificity phosphatase 14 inhibits the growth of cervical cancer cells by regulating the transforming growth factor-beta-activated kinase 1 and NOD-like receptor pyrin domain containing 3 inflammatory pathways.","authors":"Yuanyuan Zhang, Qian Zhuo, Shaliya Abuduwufu, Aerziguli Wushouer","doi":"10.1177/03000605261441200","DOIUrl":"10.1177/03000605261441200","url":null,"abstract":"<p><p>ObjectiveThis study investigated the role and mechanism of dual-specificity phosphatase 14 in cervical cancer.MethodsIn this experimental study, clinical samples from five patients with cervical squamous cell carcinoma and five with chronic cervicitis were analyzed. Dual-specificity phosphatase 14 was overexpressed in HeLa and SiHa cells. Gene and protein expression levels were analyzed using real-time quantitative polymerase chain reaction and western blot analysis. Cell viability, apoptosis, and migration were assessed using cell counting kit-8, flow cytometry as well as Transwell and wound healing assays. Cytokine levels were measured using enzyme-linked immunosorbent assay.ResultsDual-specificity phosphatase 14 expression was significantly downregulated in cervical cancer tissues and cell lines compared with that in their respective controls (<i>p</i> < 0.05). Dual-specificity phosphatase 14 overexpression markedly inhibited cell viability and induced apoptosis in HeLa and SiHa cells (<i>p</i> < 0.05). Furthermore, it significantly suppressed cell migration (<i>p</i> < 0.05). At the molecular level, dual-specificity phosphatase 14 upregulation decreased messenger ribonucleic acid levels of transforming growth factor-beta-activated kinase 1, NOD-like receptor pyrin domain containing 3, interleukin-1 beta, and tumor necrosis factor-alpha; reduced protein levels of phosphorylated transforming growth factor-beta-activated kinase 1 and NOD-like receptor pyrin domain containing 3; and diminished secretion of interleukin-1 beta and tumor necrosis factor-alpha cytokines (<i>p</i> < 0.05).ConclusionDual-specificity phosphatase 14 acts as a tumor suppressor in cervical cancer by inhibiting proliferation and migration, promoting apoptosis, and suppressing the transforming growth factor-beta-activated kinase 1/NOD-like receptor pyrin domain containing 3 inflammatory pathway, highlighting its potential as a novel therapeutic target and biomarker.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261441200"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging therapies for type 1 diabetes: Immunotherapy and gene editing advances.","authors":"Ming Zhao, Zheng Yao","doi":"10.1177/03000605261440833","DOIUrl":"10.1177/03000605261440833","url":null,"abstract":"<p><p>Type 1 diabetes is a chronic autoimmune disease involving the specific destruction of pancreatic β-cells and consequent absolute insulin deficiency. Although exogenous insulin replacement aids in hyperglycemic management, it does not cure the disease and increases the risks of hypoglycemia. Recent breakthroughs in disease-modifying therapies aim to delay, halt, or reverse disease progression via immune modulation or cell replacement. This narrative review systematically summarizes key therapeutic advances from 2023 to 2025. In immunotherapy, anti-CD3 monoclonal antibodies such as teplizumab have become the first Food and Drug Administration-approved agents to delay clinical onset in high-risk individuals. Inhibitors targeting pathways such as Janus kinase-STAT and engineered cell therapies such as chimeric antigen receptor-Tregs have also demonstrated potential for preserving residual β-cell function. For gene therapy and cell replacement, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) editing has generated \"hypoimmune\" stem cell-derived β-cells, with early clinical trials reporting instances of insulin independence without immunosuppression. Encapsulation technologies further provide a physical immune barrier for transplanted cells. Collectively, these advances mark a paradigm shift from symptomatic control to addressing core disease mechanisms through immune repair and functional restoration. Although challenges in long-term efficacy, safety, and accessibility persist, the ongoing development of combination strategies and precision medicine contributes to long-term remission and potentially a cure within reach.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261440833"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between anthropometric indices and mortality risk among individuals with depression: A population-based cohort study.","authors":"Xiangpeng Kong, Ningkun Xiao, Qingzhi Zhou, Yan Chen, Xin Zhao","doi":"10.1177/03000605261442794","DOIUrl":"10.1177/03000605261442794","url":null,"abstract":"<p><p>BackgroundFew studies have explored the associations of body mass index and waist circumference with mortality risk in patients with depression. In particular, the emergence of the obesity paradox in recent years has drawn renewed attention to the potential relationship between overweight or obesity and mortality across different populations.ObjectiveThis study aimed to investigate the associations of body mass index and waist circumference with mortality risk in individuals with depression.MethodsThis was a population-based retrospective cohort study, and participants with a body mass index <18.5 kg/m² (underweight) were excluded from the analyses. Weighted Cox regression analyses were conducted to examine the associations of body mass index and waist circumference with mortality risk in individuals with depression. Restricted cubic spline models were applied to evaluate the dose-response relationships of body mass index and waist circumference with mortality. Subgroup analyses were further conducted to explore variations in these associations across different populations, along with interaction tests to assess potential effect modification.ResultsWeighted Cox regression analysis showed that compared with individuals with a normal body mass index, those who were overweight or obese had a 53% (Model 3: hazard ratio = 0.47, 95% confidence interval: 0.29-0.76, <i>p</i> = 0.002) and 58% (hazard ratio = 0.42, 95% confidence interval: 0.27-0.67, <i>p</i> < 0.001) lower risk of all-cause mortality, respectively. Similar results were observed when waist circumference was used as the covariate for analysis, with participants in the abdominal obesity group showing a significantly lower risk of mortality than those with normal waist circumference (Model 3: hazard ratio = 0.58, 95% confidence interval: 0.37-0.89, <i>p</i> = 0.01). In the combined analysis of body mass index and waist circumference, compared with participants with normal values for these parameters, those who were overweight and had a high waist circumference had a 55% lower mortality risk (hazard ratio = 0.45, 95% confidence interval: 0.26-0.80, <i>p</i> = 0.01). Similarly, participants who were obese and had a high waist circumference had a 59% lower mortality risk (hazard ratio = 0.41, 95% confidence interval: 0.25-0.69, <i>p</i> < 0.001).ConclusionsWe found that both body mass index and waist circumference were inversely associated with mortality risk in individuals with depression, and this inverse association remained robust even when body mass index and waist circumference were jointly analyzed according to their respective categories.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261442794"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nodular fasciitis of the masseter muscle: Radiologic and pathologic correlation of a rare benign lesion.","authors":"Saeid Sadeghi Joni, Mahsa Motiei, Maryam Akbari","doi":"10.1177/03000605261436584","DOIUrl":"10.1177/03000605261436584","url":null,"abstract":"<p><p>Nodular fasciitis rarely arises from the masseter muscle and is frequently misdiagnosed as soft tissue sarcoma. A 43-year-old male presented with a rapidly enlarging, painless swelling below the right mandibular angle over 2 months. Clinical examination revealed a firm, mobile mass without skin fixation or lymphadenopathy. Ultrasound and magnetic resonance imaging were performed, followed by fine-needle aspiration cytology and excisional biopsy. Ultrasound demonstrated a well-defined, hypoechoic lobulated lesion (23 × 13 × 8 mm) within the superficial masseter, showing mild internal vascularity and no bone involvement. Magnetic resonance imaging revealed an iso- to slightly hypointense T1 signal, hyperintense T2/ short tau inversion recovery signal, and homogeneous postcontrast enhancement with smooth margins, features suggestive of a benign myofibroblastic lesion. Excisional biopsy confirmed the diagnosis of nodular fasciitis. This case indicates that masseteric nodular fasciitis, a rare benign lesion, may present with imaging features of small size, smooth margins, homogeneous enhancement, and mild vascularity in the context of trauma history. Recognition of this self-limited myofibroblastic proliferation can prevent unnecessary radical surgery and guide conservative management.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"54 4","pages":"3000605261436584"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13145052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}