Journal of International Medical Research最新文献

{"title":"Advancements in surgical modalities for corneal hydrops: A comprehensive review.","authors":"Mohammad-Ali Abtahi, Haniyeh Zeidabadinejad, Mehdi Aminizade, Emine Esra Karaca, Nicholas Tomaras, Karen Lee, Mohammad Soleimani","doi":"10.1177/03000605251372450","DOIUrl":"10.1177/03000605251372450","url":null,"abstract":"<p><p>This review critically assesses the advancements in surgical modalities designed to manage corneal hydrops effectively. As corneal hydrops presents a complex challenge in ophthalmic care, there is a growing demand for innovative surgical approaches to enhance treatment efficacy. The review evaluates the latest scientific progress in surgical strategies, offering a thorough overview of the recent interventions. By examining contemporary techniques in detail, the review aims to provide valuable insights into the ever-evolving landscape of corneal hydrops management.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372450"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Syrian conflict survivors show novel chronic cutaneous sequelae from chlorine gas exposure: A case report and literature review.","authors":"Ayham Qatza, Nabeha Haytham Alibrahim, Mariam Shaaban, Omar Alsabbagh, Alae Aldin Almasri","doi":"10.1177/03000605251378697","DOIUrl":"https://doi.org/10.1177/03000605251378697","url":null,"abstract":"<p><p>During the Syrian conflict, chlorine gas has increasingly been used as a chemical weapon, primarily causing acute respiratory injuries. However, chronic dermatological sequelae remain poorly documented, complicating long-term healthcare planning. A 70-year-old Syrian man developed pruritic ulcerative lesions on the scalp and exposed skin areas following chlorine gas exposure during a December 2016 airstrike. These lesions persisted for months after the initial exposure. Initial symptoms included ocular irritation, coughing, and dyspnea. These respiratory symptoms resolved within 48 hours; however, progressive skin changes developed. Physical examination revealed well-defined, erythematous, hyperkeratotic lesions exhibiting epidermal necrosis on the scalp and extremities. Associated findings included alopecia and hair follicle atrophy. Histopathological examination demonstrated epidermal hyperkeratosis, hypergranulosis, and dermal fibrosis with chronic perivascular inflammation. Based on clinical presentation, exposure history, exclusion of alternative etiologies, and histopathological findings, a diagnosis of chlorine-induced chronic dermatitis due to chemical warfare agent exposure was established. Treatment included oral cetirizine, prednisolone, and topical corticosteroids. At the 3-month follow-up, the chronic disease remained stable, with persistent hyperkeratotic lesions showing no significant improvement in size, erythema, or morphology. Clinicians should recognize chronic dermatopathology as an integral component of chemical warfare injuries. International health agencies should develop comprehensive registries to document long-term effects of gas exposure and to guide therapeutic strategies in conflict-affected populations.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378697"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor-negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus.","authors":"Qingqing Rao, Yuan Cheng, Shuling Yue, Haiying Song, Wangyang Li, Dongli Qi, Qijun Wan","doi":"10.1177/03000605251379806","DOIUrl":"10.1177/03000605251379806","url":null,"abstract":"<p><p>BackgroundNeural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults. However, the prognosis of neural epidermal growth factor-like 1-associated membranous nephropathy remains limited and requires further exploration.MethodsA Chinese retrospective cohort of 446 patients diagnosed with membranous nephropathy on renal biopsy was categorized into phospholipase A2 receptor-associated (n = 358) and phospholipase A2 receptor-negative (n = 88) membranous nephropathy groups. The phospholipase A2 receptor-negative group was subjected to neural epidermal growth factor-like 1 fluorescence staining. Multivariate regression analyses, stratified analyses, and Kaplan-Meier analyses were used to explore the correlation of neural epidermal growth factor-like 1 with the risk of end-stage renal disease.ResultsWe identified 11 cases of neural epidermal growth factor-like 1-associated membranous nephropathy, accounting for 12.7% of phospholipase A2 receptor-negative membranous nephropathy cases. These patients were predominantly young women with a history of fairness cream use. In patients with phospholipase A2 receptor-negative membranous nephropathy, multivariable regression analysis showed that the neural epidermal growth factor-like 1-positive group had a higher risk of end-stage renal disease compared with the neural epidermal growth factor-like 1-negative group (hazard ratio = 3.2, p = 0.026). Stratified analysis showed that this association was particularly significant in patients with systemic lupus erythematosus (hazard ratio = 5.1, p = 0.041). Kaplan-Meier analysis also revealed a higher risk in neural epidermal growth factor-like 1-positive patients (p = 0.003).ConclusionNeural epidermal growth factor-like 1 expression is an independent risk factor for end-stage renal disease, especially in patients with systemic lupus erythematosus, with an incidence rate of approximately 12.7% in patients with phospholipase A2 receptor-negative membranous nephropathy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379806"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a simple metabolic score to predict liver fibrosis risk in chronic hepatitis B patients: A retrospective cross-sectional study.","authors":"Li Liu, Peng Ye, Qiuping Gu, Ling Zeng, Lijuan Liang, Yingfeng Wei","doi":"10.1177/03000605251379253","DOIUrl":"10.1177/03000605251379253","url":null,"abstract":"<p><p>ObjectiveTo examine the association between metabolic abnormalities and liver fibrosis in patients with chronic hepatitis B and develop a simple predictive index.MethodsIn this retrospective cross-sectional study, 288 patients with chronic hepatitis B were evaluated. Significant fibrosis was defined as fibrosis-4 index ≥ 1.45 or liver stiffness ≥ 7.5 kPa. Variables with <i>P</i> < 0.10 in the univariate analysis were entered in a backward stepwise logistic regression. A fibrosis risk index was calculated from the constant term and β coefficients of significant predictors. Diagnostic performance was assessed using receiver operating characteristic curve analysis.ResultsBody mass index; fasting plasma glucose, triglyceride, uric acid, and gamma-glutamyl transferase levels; and presence of fatty liver and diabetes were independent predictors of fibrosis. The fibrosis risk index showed excellent discrimination (area under the curve = 0.928, 95% confidence interval: 0.898-0.954). The optimal cutoff (0.000148) yielded 91.6% sensitivity and 76.4% specificity.ConclusionMetabolic abnormalities are independently associated with liver fibrosis in patients with chronic hepatitis B patients. The fibrosis risk index is a simple, noninvasive tool that identifies high-risk patients for timely intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379253"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The histone deacetylase inhibitor CG-745 enhances the radiosensitivity of prostate cancer cells.","authors":"Bin Wu, Shao-Guang Liao","doi":"10.1177/03000605251371562","DOIUrl":"10.1177/03000605251371562","url":null,"abstract":"<p><p>ObjectiveTo investigate the possible correlation between histone deacetylase inhibition and radiosensitivity in PC-3 prostate cancer cells and to explore the possible mechanism involved.MethodsPC-3 prostate cancer cells were treated with 0.40 μM CG-745 alone, radiation alone, or 0.40 μM CG-745 in combination with radiation. A CCK-8 kit was used to measure the proliferation of PC-3 cells. The colony formation assay was used to determine cell reproductive survival. Immunofluorescence analysis was used to detect the location of phosphorylated H2AX foci. Apoptosis and cell cycle distribution of PC-3 cells were assessed via flow cytometry analysis.ResultsCG-745 enhances the repressive effect of irradiation on PC-3 cell growth, as shown by the CCK-8 assay and colony formation assay. Compared with CG-745 or radiation alone, CG-745 combined with radiation significantly increased phosphorylated H2AX foci formation. The combination of CG-745 and radiation significantly increased the percentage of cells in the S phase and decreased percentage of cells in the G2 and G1 phases compared with treatment with CG-745 alone or radiation alone. Flow cytometry analysis showed that CG-745 promoted the PC-3 cell apoptosis induced by radiation.ConclusionsThe histone deacetylase inhibitor CG-745 enhanced radiation-induced DNA damage, cell cycle arrest, and cell apoptosis, thus increasing the radiosensitivity of PC-3 prostate cancer cells to X-ray irradiation.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251371562"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Cryptosporidium</i> spp. infection occurring in patients with recurrent pancreatitis and primary Sjögren's syndrome: A case report.","authors":"Jian Chen, Lianli Yin, Yinghua Tang, Lilin Zhang, Qihui Chu, Hongying Zhao","doi":"10.1177/03000605251378690","DOIUrl":"10.1177/03000605251378690","url":null,"abstract":"<p><p>Cryptosporidiosis is a zoonotic protozoan disease in which diarrhea is the main clinical manifestation. <i>Cryptosporidium</i> spp. is an important opportunistic pathogenic protozoan. Inadequate clinical knowledge of the disease can easily lead to underdiagnosis. This study reports the case of a patient with recurrent pancreatitis and primary Sjögren's syndrome who was found to be infected with <i>Cryptosporidium</i> spp. After appropriate treatment, the patient's symptoms improved. Clinicians should be aware of the symptoms of cryptosporidiosis and screen for it because it is easily overlooked.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378690"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of autophagy on pseudoexfoliation syndrome.","authors":"Nazlı Can, Göksu Alaçamlı, Aylin Karalezli, Nermin Başsimitci","doi":"10.1177/03000605241306612","DOIUrl":"10.1177/03000605241306612","url":null,"abstract":"<p><p>ObjectivePseudoexfoliation syndrome is a systemic disease of unknown etiology, seen in advanced ages, characterized by extracellular material accumulation in ocular tissues and visceral organs. Autophagy, which is a basic metabolic pathway, provides macromolecule recycling of the cell and maintains cell homeostasis by adapting to the cell's stress environment. The aim of this study was to examine the relationship between specific mechanisms of autophagy and pseudoexfoliation syndrome.MethodsIn this prospective-controlled study, anterior capsulorhexis materials obtained during cataract surgery were immunohistochemically compared between eyes with and without pseudoexfoliation syndrome using Image Tool Software for possible changes in autophagy, in terms of expression levels of Beclin 1, ATG5, ATG6, ATG12, p62, and LC3A/B autophagy markers.ResultsSignificant differences were observed between the anterior capsulorhexis materials of eyes with and without pseudoexfoliation syndrome, in terms of expression levels of some specific autophagy markers.ConclusionOur study may gain importance as it is the first study in which Beclin 1, ATG5, ATG6, ATG12, p62, and LC3A/B autophagy markers are examined prospectively in the etiopathogenesis of pseudoexfoliation syndrome, comprehensively and with a control group.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605241306612"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal predictive model for strangulation risk in adhesive small bowel obstruction using deep learning and electronic health record data.","authors":"Han Wang, Jing Wu, Xianglin Ding, Zhaocheng Ruan, Shiqi Zhu, Yu Wang, Lihe Liu, Jiaxi Lin, Jinzhou Zhu, Xin Chen","doi":"10.1177/03000605251378951","DOIUrl":"10.1177/03000605251378951","url":null,"abstract":"<p><p>AimsThis study aimed to develop and validate a multimodal predictive model for the risk of strangulation in adhesive small bowel obstruction by integrating deep learning-based computed tomography imaging features and clinical electronic health records.MethodsA retrospective, observational, multicenter study was conducted across three hospitals, with data from 225 patients used for model development and 123 patients for external validation. A three-dimensional convolutional neural network with a ResNet50 backbone was used to segment abdominal regions from computed tomography scans and classify strangulation risk. The multimodal model integrated deep learning predictions with top electronic health record features using the XGBoost algorithm; global and local interpretability were achieved through variable importance ranking and local interpretable model-agnostic explanations.ResultsThe multimodal model demonstrated superior performance in predicting strangulation within 7 days of admission, achieving an area under the curve of 0.915 in the training set and 0.912 in the test set, outperforming single-modality models. Calibration plots showed good alignment between predicted and observed outcomes, decision curve analysis demonstrated significant clinical utility, and net reclassification improvement confirmed that deep learning enhanced the model's predictive ability.ConclusionThis study highlights the potential of multimodal artificial intelligence combined with clinical data to improve diagnostic accuracy and support clinical decision making in adhesive small bowel obstruction.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378951"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis as a rare neuropsychiatric manifestation of Bardet-Biedl syndrome: A case report.","authors":"Selebogo Moremi, Mpho Hubona, Taboka Maphorisa, Anthony A Olashore","doi":"10.1177/03000605251379249","DOIUrl":"https://doi.org/10.1177/03000605251379249","url":null,"abstract":"<p><p>Bardet-Biedl syndrome is a rare, pleiotropic genetic disorder. Despite advances in genetic testing, the diagnosis of Bardet-Biedl syndrome remains primarily clinical, particularly in low-resource settings. Clinical features are classified as either primary or secondary. The primary features include retinal dystrophy, central obesity, renal abnormalities, male hypogonadism, and learning disabilities. Secondary characteristics include developmental delay, dental defects, diabetes mellitus, speech disorders, brachydactyly/syndactyly, and ocular abnormalities such as nystagmus, strabismus, and astigmatism. A significant proportion of patients with Bardet-Biedl syndrome present with behavioral and psychiatric symptoms. It is estimated that one-third of patients with Bardet-Biedl syndrome meet the criteria for a major psychiatric disorder during their lifetime. However, there is a paucity of research on neuropsychiatric traits and their management in Bardet-Biedl syndrome. Herein, we report a case of psychosis in a patient with features of Bardet-Biedl syndrome and describe the multidisciplinary management provided in a psychiatric setting.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379249"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical benefits of icodextrin in peritoneal dialysis: Evidence from a multicenter, prospective, randomized controlled trial.","authors":"Yao Li, Chuanxiong Yang, Zhu Zhou","doi":"10.1177/03000605251379205","DOIUrl":"https://doi.org/10.1177/03000605251379205","url":null,"abstract":"<p><p>Background and objectiveIcodextrin is a novel, potentially advantageous peritoneal dialysis solution characterized by low glucose content and high molecular weight. This study aimed to compare the impact of icodextrin and glucose solutions on peritoneal dialysis patients.MethodsThis multicenter, prospective, randomized controlled trial included 40 peritoneal dialysis patients. Participants were randomized in a 1:1 ratio into an experimental group (icodextrin group) and a control group (glucose group). Both groups used 1.5% or 2.5% glucose dialysis solutions for three daytime exchanges. At night, the icodextrin group used 7.5% icodextrin, while the glucose group used 2.5% glucose solution. Patients were followed up bimonthly, assessing nighttime ultrafiltration, electrolytes, lipid and glucose profiles, albumin levels, and quality of life using the short form-36 health survey scale at 4 months.ResultsAfter 2 and 4 months, the icodextrin group demonstrated a considerably greater nighttime net ultrafiltration than the glucose group (P < 0.05). After 4 months, the icodextrin group exhibited lower serum sodium, chloride, and systolic blood pressure levels but higher calcium levels, albumin levels, and short form-36 health survey scores than the glucose group (P < 0.05).ConclusionsIcodextrin enhances ultrafiltration, maintains electrolyte balance, and improves nutritional status in peritoneal dialysis patients. These effects contribute toward improvement in the patients' quality of life. The protocol was registered at chictr.org.cn (Registration Number: ChiCTR2200062379).</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251379205"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}