Journal of International Medical Research最新文献_第4页

Unilateral involuntary movements of the limbs with caudate nucleus restricted diffusion on magnetic resonance imaging: A case report. 单侧肢体不自主运动伴尾状核扩散受限的磁共振成像1例。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1177/03000605251350961

Lan Deng, Bing-Hu Li

引用次数: 0

Association between long-term changes in obesity-related anthropometric indicators and the risk of type 2 diabetes mellitus in the older population. 老年人群肥胖相关人体测量指标的长期变化与2型糖尿病风险之间的关系

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-12 DOI: 10.1177/03000605251348229

Xiaomin Xu, Lirong Li, Fengmei Chen, Zhirong Guo

{"title":"Association between long-term changes in obesity-related anthropometric indicators and the risk of type 2 diabetes mellitus in the older population.","authors":"Xiaomin Xu, Lirong Li, Fengmei Chen, Zhirong Guo","doi":"10.1177/03000605251348229","DOIUrl":"10.1177/03000605251348229","url":null,"abstract":"ObjectiveTo investigate the association of long-term changes in body mass index, waist circumference, and waist-to-height ratio with the risk of type 2 diabetes mellitus in the older population.MethodsWe conducted a prospective cohort study in Jiangsu Province, China. Data from 593 participants who were aged ≥60 years were analyzed. The hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model.ResultsOver a median follow-up period of 5.08 years, 70 participants (11.80%) developed type 2 diabetes mellitus. Compared with participants with persistently normal body mass index, waist circumference, and waist-to-height ratio, those in whom these parameters changed from normal to abnormal and those in whom these parameters were persistently abnormal had a significantly higher risk of type 2 diabetes mellitus, with adjusted hazard ratios of 2.11 (95% confidence interval: 1.05-4.26) and 2.37 (95% confidence interval: 1.21-4.63) for body mass index, 2.75 (95% confidence interval: 1.16-6.51) and 2.32 (95% confidence interval: 1.29-4.16) for waist circumference, and 2.24 (95% confidence interval: 1.14-5.91) and 4.11 (95% confidence interval: 2.21-7.68) for waist-to-height ratio, respectively.ConclusionLong-term changes in obesity-related anthropometric indicators are strongly associated with the risk of type 2 diabetes mellitus in the older population.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251348229"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in resting-state brain function in chronic alcohol users based on degree centrality. 基于度中心性的慢性酒精使用者静息状态脑功能变化

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1177/03000605251345891

Guangping Su, Zhezi Wang, Yanxi Xiong, Xingwu Xie, Bencheng Mo, Yue Liu

{"title":"Changes in resting-state brain function in chronic alcohol users based on degree centrality.","authors":"Guangping Su, Zhezi Wang, Yanxi Xiong, Xingwu Xie, Bencheng Mo, Yue Liu","doi":"10.1177/03000605251345891","DOIUrl":"10.1177/03000605251345891","url":null,"abstract":"ObjectiveTo examine the effects of chronic alcohol consumption on brain functional connectivity using resting-state functional magnetic resonance imaging and degree centrality analysis.MethodsThis was a cross-sectional study, with participants including 23 light-to-moderate drinkers, 25 heavy drinkers, and 29 healthy controls aged 40-60 years. Degree centrality analysis was used to compare brain function differences among groups, and the relationships between degree centrality values, cognitive scores, and drinking behaviors were explored.ResultsHeavy drinkers showed significantly reduced degree centrality values in the left inferior temporal gyrus compared with healthy controls as well as in the left inferior temporal gyrus and left middle occipital gyrus compared with light-to-moderate drinkers. Degree centrality values in the left inferior temporal gyrus and left middle occipital gyrus were negatively correlated with drinking frequency and Michigan Alcoholism Screening Test scores but were positively correlated with cognitive scores.ConclusionsHeavy drinking significantly disrupts brain functional networks. These findings suggest a potential link between cognitive function and drinking behavior, which may inform future research on early interventions aimed at protecting brain function in chronic alcohol users.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251345891"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral tunnel widening is associated with thigh muscle weakness following anterior cruciate ligament reconstruction: A call for targeted rehabilitation. 股骨隧道加宽与前交叉韧带重建后大腿肌无力有关：呼吁有针对性的康复。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-05 DOI: 10.1177/03000605251345960

Bekir Eray Kilinc, Yunus Oc, Onur Gultekin, Ahmet Eren Sen, Demet Pepele Kurdal, Ali Varol

{"title":"Femoral tunnel widening is associated with thigh muscle weakness following anterior cruciate ligament reconstruction: A call for targeted rehabilitation.","authors":"Bekir Eray Kilinc, Yunus Oc, Onur Gultekin, Ahmet Eren Sen, Demet Pepele Kurdal, Ali Varol","doi":"10.1177/03000605251345960","DOIUrl":"10.1177/03000605251345960","url":null,"abstract":"ObjectiveTo investigate the effects of femoral tunnel widening and tibial tunnel widening on the clinical and functional outcomes of a patient after anterior cruciate ligament reconstruction.MethodsThis study evaluated patients using the International Knee Documentation Committee score, Lysholm Knee Score, and Tegner Activity Scale score. Quadriceps and hamstring strength measurements on both operated and contralateral sides were recorded using an isokinetic dynamometer. Anterior laxity was assessed using a KT-1000 arthrometer. Tunnel widening rates were calculated as percentages using three-dimensional computed tomography. Statistical analysis included paired t-tests to assess tunnel widening effects.ResultsA total of 120 patients were included, with a mean age of 28.76 ± 6.65 years and a mean follow-up duration of 21.97 ± 8.64 months. No significant differences were found in femoral tunnel widening and tibial tunnel widening values between patients with significant (≥3 mm) and nonsignificant (<3 mm) KT-1000 measurements (p > 0.05). Femoral tunnel widening and tibial tunnel widening showed no significant correlation with Lysholm Knee Score, International Knee Documentation Committee score, or Tegner Activity Scale score (p > 0.05). Femoral tunnel widening was negatively correlated with extension and flexion strength at 60°/s and 180°/s (p < 0.05), whereas tibial tunnel widening showed no such correlation (p > 0.05).ConclusionsThese findings suggest that three-dimensional computed tomography-based femoral tunnel widening measurement and isokinetic dynamometer may help identify functional deficits in symptomatic patients following anterior cruciate ligament reconstruction.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251345960"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-COVID-19 severe Pneumocystis jirovecii pneumonia in a non-HIV and immunocompetent patient: A case report and literature review. 非hiv和免疫功能正常患者感染covid -19后严重乙基肺囊虫肺炎1例报告并文献复习

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-14 DOI: 10.1177/03000605251344140

Zhi-Yang Xu, Wei Ouyang, Jin-Liang Liu, Wen-Jing Ye, Feng Xu

引用次数: 0

Non-acquired immunodeficiency syndrome-related cryptococcal meningitis with recurrent acute stroke: A case report. 非获得性免疫缺陷综合征相关隐球菌性脑膜炎伴复发性急性脑卒中1例。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-24 DOI: 10.1177/03000605251350976

Bijun Ye, Jian Wu, Yinhong Qiu, Weiqiang Fan, Jiating Xu, Yiping Tang

{"title":"Non-acquired immunodeficiency syndrome-related cryptococcal meningitis with recurrent acute stroke: A case report.","authors":"Bijun Ye, Jian Wu, Yinhong Qiu, Weiqiang Fan, Jiating Xu, Yiping Tang","doi":"10.1177/03000605251350976","DOIUrl":"10.1177/03000605251350976","url":null,"abstract":"Cryptococcal meningitis has been reported to be primarily associated with human immunodeficiency virus infection. Herein, we report the case of a male patient in China with recurrent acute stroke as the first clinical manifestation, followed by several symptoms of intracranial infection, such as headache, a stiff neck, disturbance of consciousness, and high fever. The patient tested negative for human immunodeficiency virus and was diagnosed with cryptococcal meningitis after lung computed tomography, cranial computed tomography, cranial magnetic resonance imaging, and cerebrospinal fluid examination. The combination of conventional amphotericin B and flucytosine tablets progressively worsened the patient's condition. This was accompanied by a series of complications, such as respiratory failure, hepatic and renal insufficiency, and infectious shock, leading to the patient's death. To date, only a few cases of non-acquired immunodeficiency syndrome-related cryptococcal meningitis with recurrent acute stroke have been reported. This case report suggests that clinicians should be alert to the possibility of cryptococcal meningitis in patients with imaging manifestations of meningitis and promptly perform cryptococcal capsular antigen testing, a highly sensitive screening method. Therefore, this case study could lead to new insights into the clinical diagnosis and treatment of non-acquired immunodeficiency syndrome-related cryptococcal meningitis with recurrent acute stroke.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251350976"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases. 中性粒细胞弹性蛋白酶及其抑制剂在呼吸系统疾病中的作用研究进展。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-28 DOI: 10.1177/03000605251352789

Cheng-Cheng Liang, Ji Zhao, Yan-Qiu Zhang, Jian Chen, Yong Wang

{"title":"Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases.","authors":"Cheng-Cheng Liang, Ji Zhao, Yan-Qiu Zhang, Jian Chen, Yong Wang","doi":"10.1177/03000605251352789","DOIUrl":"10.1177/03000605251352789","url":null,"abstract":"Neutrophil elastase is a serine protease secreted by neutrophils that plays a crucial role in the onset and progression of various respiratory diseases. The imbalance between neutrophil elastase and its endogenous inhibitors can contribute to the onset and progression of respiratory diseases such as chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, and acute respiratory distress syndrome. The excessive release of neutrophil elastase contributes to multiple pathophysiological processes, such as disruption of the alveolar-capillary barrier, oxidative stress and inflammatory responses, autophagy, and apoptosis. The use of neutrophil elastase as a biomarker in disease assessment and prognosis prediction as well as the potential of neutrophil elastase inhibitors in clinical treatment have shown broad application prospects. Neutrophil elastase inhibitors have certain limitations such as off-target effects, poor lung bioavailability, cost considerations, and variability in patient responses. This article reviews the literature on neutrophil elastase and its inhibitors in the field of respiratory diseases, aiming to provide new insights into the diagnosis and treatment of related respiratory diseases.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251352789"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice. 鞘氨醇-1-磷酸通过调节糖尿病小鼠心脏鞘氨醇-1-磷酸受体的平衡影响心肌血管稳态。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-06 DOI: 10.1177/03000605251346591

Guozhu Jin, Hu Zhao, Lun Li, Qian Cao, Hui Yan

{"title":"Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice.","authors":"Guozhu Jin, Hu Zhao, Lun Li, Qian Cao, Hui Yan","doi":"10.1177/03000605251346591","DOIUrl":"10.1177/03000605251346591","url":null,"abstract":"ObjectiveThis study aimed to explore the effect of sphingosine-1-phosphate on vascular homeostasis in the myocardium of diabetic mice.MethodsBioinformatics analyses were performed to analyze the targets and function of sphingosine-1-phosphate in diabetes. C57BL/6 mice were used to establish diabetic models and treated with sphingosine-1-phosphate. Pathological examination was used to evaluate the damage to the myocardium. Immunohistochemistry and western blot analyses were used to examine the expression of molecules involved in vascular function and sphingosine-1-phosphate receptors. Endothelial nitric oxide synthase level was detected via enzyme-linked immunosorbent assay.ResultsMultiple Gene Ontology entries of sphingosine-1-phosphate were associated with vascular homeostasis. Blood glucose level, food intake, and water intake increased and body weight decreased in diabetic mice, whereas these changes were relieved in the sphingosine-1-phosphate group. Sphingosine-1-phosphate alleviated the myocardial injury and restored the expression levels of vascular endothelial-cadherin, vascular endothelial growth factor, and CD31 in the myocardium of diabetic mice to some extent. The serum level of endothelial nitric oxide synthase increased in the sphingosine-1-phosphate group. Additionally, sphingosine-1-phosphate was demonstrated to act on its receptors S1PR1, S1PR2, and S1PR3, which were downregulated in the myocardium of diabetic mice and significantly upregulated after sphingosine-1-phosphate treatment.ConclusionSphingosine-1-phosphate may restore myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in diabetic mice, suggesting sphingosine-1-phosphate/sphingosine-1-phosphate receptors as potential therapeutic targets for diabetic myocardial injury.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251346591"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does diminished ovarian reserve impact oxidation-reduction potential in follicular fluid? 卵巢储备减少会影响卵泡液的氧化还原电位吗？

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1177/03000605251349926

Minh Tam Le, Nguyen Dac Nguyen, Hong Nhan Thi Dang, Quoc Huy Vu Nguyen

{"title":"Does diminished ovarian reserve impact oxidation-reduction potential in follicular fluid?","authors":"Minh Tam Le, Nguyen Dac Nguyen, Hong Nhan Thi Dang, Quoc Huy Vu Nguyen","doi":"10.1177/03000605251349926","DOIUrl":"10.1177/03000605251349926","url":null,"abstract":"ObjectiveThis study aimed to evaluate oxidative stress in follicular fluid by measuring oxidation-reduction potential and determine its correlation with embryo quality in patients with diminished ovarian reserve.MethodsThis cross-sectional study included 134 patients with diminished ovarian reserve and 82 patients with normal ovarian reserve. Follicular fluid samples were collected from each patient via transvaginal aspiration under ultrasound guidance. Oxidation-reduction potential was measured using the Male Infertility Oxidative system, following the manufacturer's protocol.ResultsThe levels of anti-Müllerian hormone, number of oocytes retrieved, rate of blastocyst formation, and rate of high-quality embryos were significantly lower in the diminished ovarian reserve group than in the normal ovarian reserve group. Correlation analysis revealed that oxidation-reduction potential values had a negative correlation with the number of oocytes retrieved (r = -0.262, p = 0.002), rate of mature oocytes (r = -0.260, p = 0.002), and rate of normal fertilization (r = -0.207, p = 0.016); however, these values showed a positive correlation with the duration of ovarian stimulation (r = 0.186, p = 0.031).ConclusionsOxidative stress in follicular fluid correlates with a small number of oocytes retrieved, lower proportion of mature oocytes, and lower rate of normal fertilization in patients with diminished ovarian reserve.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251349926"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia is linked to malnutrition among Palestinian patients aged >50 years admitted for elective surgeries, along with associated factors. 在接受选择性手术的50岁巴勒斯坦患者中，肌肉减少症与营养不良有关，并伴有相关因素。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-22 DOI: 10.1177/03000605251342030

Ali Shakhshir, May Hamdan, Islam Thaher, Nada Dweik, Ruba Abu Iram, Shurooq Osama, Manal Badrasawi

{"title":"Sarcopenia is linked to malnutrition among Palestinian patients aged >50 years admitted for elective surgeries, along with associated factors.","authors":"Ali Shakhshir, May Hamdan, Islam Thaher, Nada Dweik, Ruba Abu Iram, Shurooq Osama, Manal Badrasawi","doi":"10.1177/03000605251342030","DOIUrl":"10.1177/03000605251342030","url":null,"abstract":"ObjectiveThis study aimed to evaluate the prevalence of sarcopenia and malnutrition among patients undergoing elective operations and the associated factors.MethodsA cross-sectional study design was used to analyze data collected from 111 participants (60 males and 51 females) aged ≥50 years. The European Working Group on Sarcopenia in Older People criteria were used to define sarcopenia; anthropometric measurements, body composition data, and Mini Nutritional Assessment-Short Form questionnaire responses were used to assess the nutritional status of the participants.ResultsThe prevalence rates of malnutrition and sarcopenia were 34% and 39%, respectively, in the study population. In addition, we found that malnourished patients were more likely to be female, unemployed, diabetic, and dyslipidemic. The study also showed that patients with sarcopenia were more likely to be older and have diabetes.ConclusionsMalnutrition, diagnosed using the Mini Nutritional Assessment-Short Form questionnaire, is associated with sarcopenia, female sex, working condition, diabetes, and dyslipidemia. A significant association was reported between sarcopenia, age, and diabetes.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251342030"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0