Journal of International Medical Research最新文献

{"title":"Machine learning analysis of FOSL2 and RHoBTB1 as central immunological regulators in knee osteoarthritis synovium.","authors":"Kun Gao, Zhenyu Huang, Zhouwei Liao, Yanfei Wang, Dayu Chen","doi":"10.1177/03000605251333646","DOIUrl":"https://doi.org/10.1177/03000605251333646","url":null,"abstract":"<p><p>BackgroundKnee osteoarthritis is a debilitating disease with a complex pathogenesis. Synovitis, which refers to inflammation of the synovial membrane surrounding the joint, is believed to play an important role in the development and progression of knee osteoarthritis. To better understand the molecular mechanisms underlying knee osteoarthritis, we conducted a comprehensive analysis of gene expression in knee osteoarthritis synovium using machine learning.MethodsDifferentially expressed genes between knee osteoarthritis and control synovial tissues were analyzed using the GSE55235 dataset. We employed several machine learning algorithms, including least absolute shrinkage and selection operator and support vector machine-recursive feature elimination, to screen for key genes. Then, we validated the key genes using an external dataset (GSE51588) and an in vitro knee osteoarthritis animal model. CIBERSORT was used to compare immune cell infiltration levels between knee osteoarthritis and control synovial tissues and determine their relationship with the key genes. Finally, we performed a Connectivity Map analysis to screen for potential small-molecule compounds. Moreover, we conducted single-cell RNA sequencing analysis using knee joint tissues to annotate different subtypes of cells.ResultsA total of 930 differentially expressed genes were identified. Least absolute shrinkage and selection operator regression and support vector machine-recursive feature elimination identified <i>FOSL2</i> and <i>RHoBTB1</i> as key genes. The expression levels of both genes were further validated in the GSE51588 dataset as well as verified through an in vitro experiment involving a knee osteoarthritis mouse model. Multiple significant correlation pairs were found between the immune cell infiltration levels. We unveiled the genetic basis of knee osteoarthritis using genome-wide association study and specific signaling pathways through gene set enrichment analysis. The GeneCards database was used to obtain 3032 pathogenic genes associated with knee osteoarthritis, and we found that <i>RHoBTB1</i> expression was significantly negatively correlated and <i>FOSL2</i> expression was significantly positively correlated with interleukin-1β expression. We predicted several small-molecule compounds based on Connectivity Map analysis. Finally, single-cell RNA sequencing analysis revealed the expression levels of the two key genes in chondrocytes and tissue stem cells.Conclusion<i>FOSL2</i> and <i>RHoBTB1</i> may play key roles in the pathogenesis of knee osteoarthritis, exhibiting correlations with immune cell infiltration levels. These findings indicate that these genes have potential as therapeutic targets. However, further research and validation are necessary to confirm their exact roles and therapeutic potential in knee osteoarthritis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251333646"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic fasciitis following postpartum: A rare case report.","authors":"Guozheng Zhang, Xingjian Xu, Xiaowei Han, Weitao Huang","doi":"10.1177/03000605251332195","DOIUrl":"https://doi.org/10.1177/03000605251332195","url":null,"abstract":"<p><p>Eosinophilic fasciitis is a rare connective tissue disease characterized by increased levels of peripheral blood eosinophils and infiltration in the myofascia. The diagnosis of eosinophilic fasciitis is primarily based on clinical manifestations, laboratory tests, and pathological biopsy, with the exclusion of other possible causes of fasciitis and eosinophil increase. Herein, we report a case of postnatal eosinophilic fasciitis occurring in a woman in her 20s, who developed the condition in her right forearm. The patient, who was postpartum, showed considerable recovery after conservative treatment with the corticosteroid prednisone.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251332195"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprachoroidal hemorrhage associated with cataract surgery: A case series analysis.","authors":"Rubing Liu, Beiling Tan, Han Wang, Zebin Li, Furong Luo, Jifa Kuang, Mingbing Zeng","doi":"10.1177/03000605251332434","DOIUrl":"https://doi.org/10.1177/03000605251332434","url":null,"abstract":"<p><p>This study aimed to identify risk factors, evaluate management strategies, and assess visual outcomes of suprachoroidal hemorrhage during cataract surgery through a retrospective analysis of five clinical cases and a literature review. We analyzed five cases of suprachoroidal hemorrhage occurring during phacoemulsification cataract surgery with intraocular lens implantation or intrascleral fixation of intraocular lens haptics at our institution (January 2013-September 2024). Among 48,725 cataract surgeries, five cases of suprachoroidal hemorrhage were identified (incidence: 0.01%). Key risk factors included preoperative angle-closure glaucoma (two cases), prior cataract surgery with vitrectomy (two cases), and advanced age (one case, mid-70s). Intraoperative suprachoroidal hemorrhage occurred in two cases (one with posterior capsular rupture), whereas the condition developed postoperatively in three cases. Management strategies comprised pars plana vitrectomy with scleral drainage (three cases), vitrectomy combined with intravitreal triamcinolone injection (one case), and conservative treatment (one case). The mean preoperative visual acuity improved significantly from 2.22 LogMAR to 0.6 LogMAR at the final follow-up (P = 0.007). These findings suggest that, in addition to the previously reported major risk factors for suprachoroidal hemorrhage, such as advanced age, glaucoma, and multiple surgeries, secondary intraocular lens implantation is a major risk factor. Comprehensive preoperative evaluation and meticulous control of intraoperative intraocular pressure fluctuations are essential to mitigate suprachoroidal hemorrhage risks and optimize surgical outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251332434"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of enteral nutrition during prone ventilation: A meta-analysis.","authors":"Pan Jianzhen, Gu Mei, Zhao Jianghong, Chen Fei, Chen Lili","doi":"10.1177/03000605251322358","DOIUrl":"10.1177/03000605251322358","url":null,"abstract":"<p><p>BackgroundProne ventilation improves lung function in patients with acute respiratory distress syndrome by enhancing oxygenation; however, managing enteral nutrition during prone ventilation is challenging due to body position changes.ObjectiveThe objective of the study was to assess the safety and efficacy of enteral nutrition during prone ventilation. A meta-analysis was conducted to evaluate the efficacy and safety of enteral nutrition in the prone position in critically ill ventilated patients.MethodsBy searching databases such as PubMed, Embase, Cochrane Library, Web of Science, Cumulative Index of Nursing and Allied Health Literature, and WanFang Data, the relevant literature was retrieved from their inception to 24 December 2024. The Newcastle-Ottawa Scale was used to evaluate article quality. Egger's test was used to check for publication bias, and Review Manager 5.4 was used to conduct the analyses.ResultsAmong 81 publications, five studies with a total sample size of 319 were included in this study. Enteral nutrition in the prone position, compared with that in the supine position, was associated with a lower energy achievement rate (mean difference: -0.88; 95% confidence interval: -1.83 to 0.06; P < 0.00001), no significant difference in mortality (odds ratio: 1.11; 95% confidence interval: 0.65 to 1.88; P = 0.7), a greater incidence of ventilator-associated pneumonia (odds ratio: 2.11; 95% confidence interval: 1.12 to 3.96; P = 0.02), more frequent vomiting (odds ratio: 2.38; 95% confidence interval: 1.61 to 3.50; P < 0.0001), a greater gastric residual volume (odds ratio: 2.72; 95% confidence interval: 1.47 to 5.03; P = 0.001), and increased interruptions in enteral nutrition (odds ratio: 4.75; 95% confidence interval: 2.22 to 10.17; P < 0.0001). The Egger's test suggested no significant publication bias in the meta-analysis of mortality, gastric residual volume, adequate enteral nutrition achievement, and ventilator-associated pneumonia.ConclusionA greater gastric residual volume, more frequent vomiting, and greater incidences of ventilator-associated pneumonia and enteral feeding interruptions are linked to enteral nutrition during prone ventilation. There was no statistically significant difference in mortality between the prone and supine positions. However, the prone position showed a slight trend toward reducing energy achievement rates, although this difference was not statistically significant.<b>Trial registration number:</b> PROSPERO CRD: 42023441409.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251322358"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic gastroenteritis with severe gastrointestinal intolerance: A case report and literature review.","authors":"Chen-Xiang Wei, Yi-De Gao, Rong Liang, Tao Lyu","doi":"10.1177/03000605251332886","DOIUrl":"https://doi.org/10.1177/03000605251332886","url":null,"abstract":"<p><p>Eosinophilic gastroenteritis is a rare gastrointestinal disease characterized by eosinophilic infiltration of the gastrointestinal mucosa, muscle layer, or serosal layer. Gastrointestinal symptoms, laboratory tests, imaging, and endoscopy can provide important diagnostic basis for eosinophilic gastroenteritis, but the final diagnosis needs to be confirmed via pathological biopsy. We herein report the case of a middle-aged woman with abdominal pain for 5 days, which was aggravated for 1 day. Gastroscopic pathology showed individual nondiffuse eosinophils (concentration of <10 eosinophils/high power field) in the fundus and antrum. Eosinophils with a maximum concentration of 80/high power field were uniformly distributed in the stroma and specific epithelium of the duodenal bulb. Eosinophils were infiltrated in the submucosa as well as the perivascular and vascular walls of the descending duodenum, with a maximum concentration of approximately 130/high power field. After 5 days of intravenous meprednisolone treatment, the symptoms improved and the patient was discharged healthy. After reviewing the literature, we recommend that if a patient exhibits gastrointestinal symptoms and elevated blood eosinophil levels with co-existing atopic diseases, such as asthma and allergic rhinitis, the clinician should perform gastroenteroscopy and pathological biopsy after ruling out tumor, tuberculosis, and infection.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251332886"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of TMEM119 in gastric adenocarcinoma and its specific effects on immunity.","authors":"Yating Liu, Xin Yan, Caihao Qu, Futian Tang, Qian Wang, Yumin Li","doi":"10.1177/03000605241306668","DOIUrl":"https://doi.org/10.1177/03000605241306668","url":null,"abstract":"<p><p>ObjectiveTo investigate the prognostic significance and immunological implication of transmembrane protein 119 (TMEM119) in stomach adenocarcinoma (STAD).MethodsThis study included STAD-associated data obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. In addition, <i>TMEM119</i> expression levels were analysed by immunohistochemistry in tissue samples from patients with STAD (with microsatellite instability or microsatellite stability). Gene Set Enrichment Analysis (GSEA) was conducted to explore signalling pathways related to TMEM119 in STAD. Additionally, CIBERSORT and ESTIMATE algorithms were applied to examine the relationship between <i>TMEM119</i> expression and tumour-infiltrating immune cells, as well as the tumour microenvironment.ResultsSurgical specimens from 100 patients with STAD (50 each with microsatellite stability or microsatellite instability); TCGA RNA-sequence and clinical data from 375 STAD tumour tissues and 32 paracancerous tissues; and two GEO datasets (GSE27342, comprising 80 paracancerous tissues and 80 tumour tissues; and GSE84437, comprising 433 tumour samples) were analysed. TMEM119 was found to be elevated in STAD, and associated with poor prognosis. Clinical gastric cancer tissues exhibited increased <i>TMEM119</i> expression. <i>TMEM119</i> was enriched in immune-related functions and pathways. <i>TMEM119</i> correlated with immune checkpoint genes, tumour mutational burden, and microsatellite instability. TMEM119 was positively correlated with tumour-infiltrating immune cells, tumour microenvironment, mannose receptor C-type I (CD206), and programmed cell death-ligand 1 (PD-L1), while inversely related to nitric oxide synthase 2.ConclusionsTMEM119 may be a potential immune-related biomarker for STAD prognosis and therapeutic targeting.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605241306668"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery for pseudoaneurysm following the Bentall procedure in a patient with Behçet's disease: A case report.","authors":"Dou Yuan","doi":"10.1177/03000605251332907","DOIUrl":"https://doi.org/10.1177/03000605251332907","url":null,"abstract":"<p><p>Behçet's disease, also known as the oral-ocular-genital syndrome, is a chronic systemic vasculitis characterized by recurrent oral and genital ulcers as well as ocular manifestations such as uveitis and conjunctivitis. When the cardiovascular system is predominantly affected, the condition is known as cardiac Behçet's disease. This variant can manifest as aortic valve regurgitation, conduction system disorders, myocarditis, and even acute myocardial infarction. Aortic regurgitation is an exceedingly rare and threatening cardiovascular complication in patients with Behçet's disease, often indicating a poor prognosis. Surgical intervention for aortic regurgitation in patients with Behçet's disease is associated with high risks of postoperative complications and mortality. To mitigate these risks, techniques such as the Bentall procedure have been employed. This report describes the case of a patient with Behçet's disease and severe aortic regurgitation who underwent the Bentall procedure. Unfortunately, the patient developed a pseudoaneurysm and prosthetic valve detachment at the aortic root 3 months postoperatively. This severe complication necessitated a subsequent intervention utilizing the Cabrol technique for correction.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251332907"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Painless postauricular mass: An atypical presentation of Kikuchi-Fujimoto disease.","authors":"Ren-He Chen, Ke-Yun Ding, Zhi-Guo Zhao, Fang-Zhou Chen, Guo-Rui Li","doi":"10.1177/03000605251332902","DOIUrl":"https://doi.org/10.1177/03000605251332902","url":null,"abstract":"<p><p>Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare self-limiting condition primarily characterized by cervical lymphadenopathy and fever. This report presents the case of a Han Chinese woman in her early 40s who had no significant medical history and presented with a painless mass behind her ear. She denied systemic symptoms such as fever, night sweats, or weight loss. Physical examination revealed a non-tender, mobile mass in the postauricular region. Initial ultrasound suggested a small cystic structure, and the mass was subsequently excised. Initial pathology reported reactive lymphoid hyperplasia; however, due to atypical presentation, immunohistochemical staining was performed, which was positive for multiple markers consistent with Kikuchi-Fujimoto disease. The patient did not receive specific treatment and remained asymptomatic with no recurrence at 1-month follow-up. The patient lacked typical lymph node pain and fever. The absence of typical lymph node pain and fever in the patient in this case highlights the importance of considering Kikuchi-Fujimoto disease in the differential diagnosis of painless lymphadenopathy and underscores the significance of histopathological examination and immunohistochemical analysis in reaching a definitive diagnosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251332902"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White spot lesion in self-ligating versus conventional ligating bracket systems: A systematic review.","authors":"Mohammad I Idris, Ahmad S Burhan, Mohammad Y Hajeer, Ahmad M Alhamwi, Fehmie R Nawaya","doi":"10.1177/03000605251328608","DOIUrl":"https://doi.org/10.1177/03000605251328608","url":null,"abstract":"<p><p>BackgroundWhite spot lesion formation around orthodontic brackets is a major complication associated with fixed orthodontic treatment.ObjectiveThis review aimed to evaluate the current evidence regarding the differences in white spot lesion formation between self-ligating and conventional ligating brackets.MethodsEleven bibliographic databases were searched until January 2025. This review covered parallel-group and split-mouth randomized controlled trials, controlled clinical trials, and cross-sectional studies that investigated the differences in white spot lesion formation between self-ligating and conventional ligating brackets.ResultsThree randomized controlled trials, one controlled clinical trial, and one cross-sectional study were included in this systematic review. Among these, three studies were classified as having a low risk of bias. Four of the five included studies showed no statistically significant difference in white spot lesion formation between the two types of bracket systems (p < 0.05).ConclusionThere are no potential differences in white spot lesion formation between self-ligating and conventional ligating bracket systems. However, orthodontists must be aware of the other factors affecting white spot lesion formation, with oral hygiene being the most critical factor.<b>Registration:</b> The protocol was registered in the PROSPERO database (CRD42022353478) on 25 August 2022.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251328608"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucosamine supplementation contributes to reducing the risk of type 2 diabetes: Evidence from Mendelian randomization combined with a meta-analysis.","authors":"Shuai Zhou, Peiwen Zhou, Tianshi Yang, Junzhuo Si, Wenyan An, Yanfang Jiang","doi":"10.1177/03000605251334460","DOIUrl":"https://doi.org/10.1177/03000605251334460","url":null,"abstract":"<p><p>ObjectiveObservational studies on glucosamine supplementation and type 2 diabetes risk have shown inconsistent results, necessitating the use of Mendelian randomization to clarify the true causal relationship.MethodsThe glucosamine supplementation-related genome-wide association study dataset was obtained from the MRC Integrative Epidemiology Unit consortium, whereas type 2 diabetes-related genome-wide association study datasets were obtained from the FinnGen consortium (discovery) and Xue et al.'s meta-analysis (validation). Two-sample Mendelian randomization analyses were performed separately in the discovery and validation datasets, followed by meta-analysis and multivariable Mendelian randomization analyses to verify the robustness of the results of two-sample Mendelian randomization. The estimation of the causal relationship was conducted through the inverse variance weighted method.ResultsGlucosamine supplementation exhibited a significant protective effect against type 2 diabetes, as identified by two-sample Mendelian randomization analysis in the FinnGen consortium (odds ratio: 0.13, 95% confidence interval: 0.02-0.89) and validated in Xue et al.'s meta-analysis (odds ratio: 0.06, 95%; confidence interval: 0.01-0.29). A combined meta-analysis (odds ratio: 0.08, 95%; confidence interval: 0.02-0.27) of the results of two-sample Mendelian randomization confirmed the robustness of these findings. Additionally, multivariable Mendelian randomization analysis (odds ratio: 0.12, 95%; confidence interval: 0.02-0.94), after adjusting for confounding factors, supported the results of two-sample Mendelian randomization. No evidence of heterogeneity or pleiotropy was observed.ConclusionOverall, our results revealed that genetically predicted glucosamine supplementation was inversely associated with the risk of type 2 diabetes, highlighting the potential importance of glucosamine supplementation in preventing type 2 diabetes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251334460"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}