Association between long-term changes in obesity-related anthropometric indicators and the risk of type 2 diabetes mellitus in the older population.

IF 1.5 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-12 DOI:10.1177/03000605251348229

Xiaomin Xu, Lirong Li, Fengmei Chen, Zhirong Guo

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引用次数: 0

Abstract

ObjectiveTo investigate the association of long-term changes in body mass index, waist circumference, and waist-to-height ratio with the risk of type 2 diabetes mellitus in the older population.MethodsWe conducted a prospective cohort study in Jiangsu Province, China. Data from 593 participants who were aged ≥60 years were analyzed. The hazard ratios and 95% confidence intervals were estimated using the Cox proportional hazards model.ResultsOver a median follow-up period of 5.08 years, 70 participants (11.80%) developed type 2 diabetes mellitus. Compared with participants with persistently normal body mass index, waist circumference, and waist-to-height ratio, those in whom these parameters changed from normal to abnormal and those in whom these parameters were persistently abnormal had a significantly higher risk of type 2 diabetes mellitus, with adjusted hazard ratios of 2.11 (95% confidence interval: 1.05-4.26) and 2.37 (95% confidence interval: 1.21-4.63) for body mass index, 2.75 (95% confidence interval: 1.16-6.51) and 2.32 (95% confidence interval: 1.29-4.16) for waist circumference, and 2.24 (95% confidence interval: 1.14-5.91) and 4.11 (95% confidence interval: 2.21-7.68) for waist-to-height ratio, respectively.ConclusionLong-term changes in obesity-related anthropometric indicators are strongly associated with the risk of type 2 diabetes mellitus in the older population.

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老年人群肥胖相关人体测量指标的长期变化与2型糖尿病风险之间的关系

目的探讨老年人体重指数、腰围和腰高比的长期变化与2型糖尿病发病的关系。方法我们在中国江苏省进行了一项前瞻性队列研究。分析了593名年龄≥60岁的参与者的数据。使用Cox比例风险模型估计风险比和95%置信区间。结果在5.08年的中位随访期间，70名参与者（11.80%）发展为2型糖尿病。与体质指数、腰围和腰高比持续正常的受试者相比，体质指数由正常变为异常和持续异常的受试者发生2型糖尿病的风险显著增加，体质指数调整后的风险比分别为2.11（95%可信区间：1.05 ~ 4.26）和2.37(95%可信区间：1.21 ~ 4.63),2.75(95%可信区间：腰围为1.16 ~ 6.51)，腰围为2.32(95%可信区间为1.29 ~ 4.16)，腰高比为2.24(95%可信区间为1.14 ~ 5.91)，腰高比为4.11（95%可信区间为2.21 ~ 7.68）。结论肥胖相关人体测量指标的长期变化与老年人群发生2型糖尿病的风险密切相关。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605