Journal of International Medical Research最新文献

Development and validation of a predictive nomogram for sepsis-associated severe anemia. 脓毒症相关严重贫血预测图的开发和验证。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 DOI: 10.1177/03000605251381470

Liuniu Xiao, Xiao Ran, Shusheng Li

{"title":"Development and validation of a predictive nomogram for sepsis-associated severe anemia.","authors":"Liuniu Xiao, Xiao Ran, Shusheng Li","doi":"10.1177/03000605251381470","DOIUrl":"10.1177/03000605251381470","url":null,"abstract":"ObjectiveThis study aimed to develop and validate a predictive risk nomogram for sepsis-associated severe anemia.MethodsA prediction model was built using data from 252 sepsis patients in a single institution (January 2022 to December 2023). Severe anemia was defined as a hemoglobin level <60 g/L. Least absolute shrinkage and selection operator regression was used to identify key predictors, and multivariable logistic regression was used to construct the nomogram. Model performance was assessed via the receiver operating characteristic curve (C-index), calibration plots, and decision curve analysis. Internal validation was performed using bootstrapping.ResultsPredictors included age, length of intensive care unit stay, nutritional method, and Acute Physiology and Chronic Health Evaluation II score. The model demonstrated good discrimination (C-index: 0.8848) and calibration, with high internal validation performance. Decision curve analysis indicated optimal clinical utility at risk thresholds between 5% and 75%.ConclusionsThe constructed nomogram, incorporating age, length of intensive care unit stay, nutritional method, and Acute Physiology and Chronic Health Evaluation II score, provides a practical tool for early individualized care in sepsis patients.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251381470"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe delayed coagulopathy caused by cefoperazone/sulbactam: A case report. 头孢哌酮/舒巴坦致严重迟发性凝血功能障碍1例。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 DOI: 10.1177/03000605251375259

Siqin Sun, Yixuan Wang, Jie Min, Zhidan Wang, Lei Yu

{"title":"Severe delayed coagulopathy caused by cefoperazone/sulbactam: A case report.","authors":"Siqin Sun, Yixuan Wang, Jie Min, Zhidan Wang, Lei Yu","doi":"10.1177/03000605251375259","DOIUrl":"https://doi.org/10.1177/03000605251375259","url":null,"abstract":"This case report described a suspected severe coagulopathy attributed to cefoperazone/sulbactam, and this adverse reaction might be associated with the inhibition of the vitamin K cycle by cefoperazone/sulbactam, leading to vitamin K deficiency within the body. We reported a patient diagnosed with bacterial pneumonia, who received cefoperazone/sulbactam during hospitalization. The patient was administered cefoperazone/sulbactam via intravenous infusion at a dose of 1.5 g every 8 h for a consecutive treatment period of 23 days. On the 26th day, the patient developed a serious adverse reaction characterized by prolonged clotting time. After treatment with vitamin K1, the coagulation parameters significantly improved by the 28th day (prothrombin time decreased by 88.4%, activated partial thromboplastin time decreased by 61.1%, and international normalized ratio decreased by 88.5%). The Naranjo assessment score was 5, suggesting that the patient's coagulation disorder could be related to the use of cefoperazone/sulbactam. This report highlights that patients at high risk of bleeding should be vigilant about the coagulopathy caused by cefoperazone/sulbactam- and extend the duration of coagulopathy monitoring.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251375259"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-mediated extraocular myositis in an adolescent following coronavirus disease 2019: A case report. 2019冠状病毒病后青少年免疫介导的眼外肌炎1例报告

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 Epub Date: 2025-10-09 DOI: 10.1177/03000605251384077

Yixiang Wu, Xiao Chen, Zheng Fan, Mingyu Ren

{"title":"Immune-mediated extraocular myositis in an adolescent following coronavirus disease 2019: A case report.","authors":"Yixiang Wu, Xiao Chen, Zheng Fan, Mingyu Ren","doi":"10.1177/03000605251384077","DOIUrl":"https://doi.org/10.1177/03000605251384077","url":null,"abstract":"A wide spectrum of ocular manifestations have been documented in patients following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nevertheless, bilateral extraocular myositis specifically associated with natural SARS-CoV-2 infection has been rarely reported. We report the case of an East Asian adolescent female who presented with right ocular discomfort and diminished visual acuity for 2 weeks. A SARS-CoV-2 infection had been confirmed via reverse transcriptase-polymerase chain reaction 10 days ago. Magnetic resonance imaging of the orbits revealed bilateral eyelid swelling and diffuse, asymmetric thickening of the extraocular muscles, suggestive of myositis. Symptoms and imaging findings improved markedly with high-dose corticosteroids; however, recurrence occurred upon rapid tapering. The inflammation ultimately resolved with a more gradual tapering regimen, and no recurrence was observed during 12 months of follow-up. This case underscores that natural SARS-CoV-2 infection can trigger immune-mediated bilateral extraocular myositis, posing vision-threatening risks. Corticosteroids are effective, but gradual withdrawal is essential to prevent relapse.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251384077"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical application of anterior segment optical coherence tomography in ocular emergencies: A comprehensive review. 前段光学相干断层扫描在眼科急症中的临床应用综述。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 Epub Date: 2025-10-08 DOI: 10.1177/03000605251382298

Hassan Asadigandomani, Ali Momeni, Omar Nusair, Kimia Daneshvar, Houri Esmaeilkhanian, Ghazal Ghochani, Pouria Ahmadi, Alireza Razavi, Hamidreza Esfandiari, Mohammad Soleimani

{"title":"Clinical application of anterior segment optical coherence tomography in ocular emergencies: A comprehensive review.","authors":"Hassan Asadigandomani, Ali Momeni, Omar Nusair, Kimia Daneshvar, Houri Esmaeilkhanian, Ghazal Ghochani, Pouria Ahmadi, Alireza Razavi, Hamidreza Esfandiari, Mohammad Soleimani","doi":"10.1177/03000605251382298","DOIUrl":"https://doi.org/10.1177/03000605251382298","url":null,"abstract":"This narrative review explored the comprehensive clinical applications of anterior segment optical coherence tomography in cases of ocular trauma and emergencies, with a focus on its diagnostic, therapeutic, and future implications. A literature search was conducted via PubMed, Scopus, and Web of Science using relevant keywords, yielding 86 articles for inclusion. However, no formal systemic review or meta-analysis was performed. These studies highlight the role of anterior segment optical coherence tomography as a high-resolution, noncontact imaging modality that enables detailed assessment of anterior segment injuries, even in cases with compromised visualization due to corneal opacity or hyphema. Anterior segment optical coherence tomography facilitates accurate diagnosis of corneal lacerations, intraocular foreign bodies, traumatic cataracts, and angle abnormalities, contributing significantly to surgical planning. Moreover, anterior segment optical coherence tomography angiography provides novel insights into anterior segment vasculature; for instance, it helps detect limbal ischemia in chemical injuries. Despite its numerous benefits, anterior segment optical coherence tomography is limited by its inability to image structures posterior to the iris and its reliance on patient cooperation for accurate imaging. Overall, anterior segment optical coherence tomography has transformed the evaluation and management of ocular emergencies by enhancing structural visualization and improving clinical decision-making. Future innovations, including enhanced penetration depth and integration of artificial intelligence, are expected to further expand its diagnostic and therapeutic potential.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251382298"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel mutation in the transglutaminase-1 gene identified in a collodion baby: A case report. 一个新的突变在转谷氨酰胺酶-1基因鉴定在一个collodion婴儿：一个病例报告。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 Epub Date: 2025-10-08 DOI: 10.1177/03000605251382379

Wang Lixiang, Li Xianghong, Yang Lexia, Xi Hongmin, Li Liangliang

{"title":"A novel mutation in the transglutaminase-1 gene identified in a collodion baby: A case report.","authors":"Wang Lixiang, Li Xianghong, Yang Lexia, Xi Hongmin, Li Liangliang","doi":"10.1177/03000605251382379","DOIUrl":"https://doi.org/10.1177/03000605251382379","url":null,"abstract":"Autosomal recessive congenital ichthyosis is a group of skin disorders characterized by abnormal keratinization. The collodion baby phenotype is a rare phenotype of autosomal recessive congenital ichthyosis characterized by a tight, translucent membrane that encases the newborn, which leads to significant medical challenges. This case report describes a male infant born at 35 weeks and 6 days of gestation who presented with the collodion baby syndrome. The present case exhibited a nonbullous congenital ichthyosiform erythroderma-like phenotype, characterized by diffuse erythema and fine scaling. Genetic analysis revealed two compound heterozygous mutations in TGM1: c.425G>T (p.Arg142Leu) in exon 3, previously reported as a pathogenic hotspot in nonbullous congenital ichthyosiform erythroderma, and a novel mutation, c.1198A>C (p.Asn400His) in exon 8, which has not only been associated with lamellar ichthyosis but has also been detected in nonbullous congenital ichthyosiform erythroderma. A comprehensive treatment strategy focused on symptom alleviation and supportive care led to significant improvement, and the infant was discharged after 6 days of hospitalization. This case highlights the importance of early diagnosis, multidisciplinary care, and genetic testing in managing autosomal recessive congenital ichthyosis. The identification of novel TGM1 mutations contributes to the expanding mutation spectrum and may inform future diagnostic and therapeutic approaches.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251382379"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Painful diabetic neuropathy complicated with secondary erythromelalgia in polycythemia vera: A case report. 真性红细胞增多症并发继发性红斑性肢痛症的疼痛性糖尿病神经病变1例。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 DOI: 10.1177/03000605251382382

Hong Zhang, Zhengran Qin, Xiaohong Feng

引用次数: 0

Retrospective analysis of flexible ureteroscopic lithotripsy using end-fire, flexible negative-pressure ureteral access sheath for the management of 2-3-cm kidney stones. 输尿管软腔镜碎石术治疗2- 3cm肾结石的回顾性分析。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 Epub Date: 2025-10-06 DOI: 10.1177/03000605251381472

Chenglong Wu, Cong Yin, Jieqing Chen, Qiaolin Mei, Yujia Sun, Hongbing Mei, Xinhui Liao

{"title":"Retrospective analysis of flexible ureteroscopic lithotripsy using end-fire, flexible negative-pressure ureteral access sheath for the management of 2-3-cm kidney stones.","authors":"Chenglong Wu, Cong Yin, Jieqing Chen, Qiaolin Mei, Yujia Sun, Hongbing Mei, Xinhui Liao","doi":"10.1177/03000605251381472","DOIUrl":"https://doi.org/10.1177/03000605251381472","url":null,"abstract":"ObjectiveTo compare the efficacy and safety of flexible ureteroscopic lithotripsy using end-fire flexible negative-pressure ureteral access sheath (F-UAS) versus traditional ureteral access sheath (T-UAS) for 2-3-cm kidney stones.MethodsThis retrospective case-control study included 136 patients with kidney stones treated with flexible ureteroscopic lithotripsy using F-UAS at Shenzhen Second People's Hospital from November 2022 to November 2023 (F-UAS group) and 132 patients treated with flexible ureteroscopic lithotripsy using T-UAS from November 2021 to October 2022 (T-UAS group). Preoperative assessments included imaging studies (kidney, ureter, and bladder X-ray; noncontrast computed tomography; and renal ultrasound) and laboratory tests (complete blood count, biochemical tests, coagulation function, and urine culture). The stone clearance rate, operation time, intraoperative blood loss, and complications were compared between the two groups.ResultsBaseline characteristics of the two groups were balanced. The F-UAS group showed significantly higher stone clearance rate (91.9% vs. 81.8%, p = 0.014), shorter operation time (51.0 ± 13.9 vs. 59.8 ± 18.2 min, p < 0.001), and lower postoperative antibiotic use (2.9% vs. 6.8%, p = 0.027) than the T-UAS group. The intraoperative blood loss and length of hospital stay did not differ significantly between the two groups.ConclusionsFlexible ureteroscopic lithotripsy using F-UAS improves stone clearance, reduces infection-related complications, and shortens operation time compared with that using T-UAS in the treatment of 2-3-cm kidney stones. Further prospective studies are warranted to confirm these findings.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251381472"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonlinear association between the immunonutritional index hemoglobin, albumin, lymphocytes, and platelets score and hyperuricemia: A cross-sectional study involving 12,598 adults. 免疫营养指数血红蛋白、白蛋白、淋巴细胞和血小板评分与高尿酸血症之间的非线性关联：一项涉及12598名成年人的横断面研究。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 DOI: 10.1177/03000605251380995

Manli Yan, Wenhua Shi, Haoyu Wang, Xiang Li

{"title":"Nonlinear association between the immunonutritional index hemoglobin, albumin, lymphocytes, and platelets score and hyperuricemia: A cross-sectional study involving 12,598 adults.","authors":"Manli Yan, Wenhua Shi, Haoyu Wang, Xiang Li","doi":"10.1177/03000605251380995","DOIUrl":"10.1177/03000605251380995","url":null,"abstract":"BackgroundThe prevalence of hyperuricemia is increasing, posing a significant health concern, particularly in China, where it affects 13.3% of the population. Traditional nutritional perspectives do not fully explain hyperuricemia, and the relationship between immune status and hyperuricemia remains unclear.ObjectiveThis study aimed to examine the association between the immunonutritional index-hemoglobin, albumin, lymphocytes, and platelets (HALP) score-and hyperuricemia.MethodsIn this retrospective cross-sectional study, clinical data from 12,598 adults at Guangdong Provincial Hospital of Chinese Medicine were analyzed using SPSS and R.ResultsAmong the total participants, 3422 had hyperuricemia. Significant differences in immune-related indices were observed, with the HALP score showing a higher area under the curve (0.675, 95% confidence interval: 0.665-0.686) than traditional markers. HALP was significantly and nonlinearly associated with hyperuricemia risk, with an inflection point of 53.85. Below this threshold, each unit increase in HALP was associated with a 1.9% increase in risk (p < 0.001).ConclusionThis cross-sectional study identified a nonlinear association between the HALP score and the prevalence of hyperuricemia. These findings suggest that HALP serves as a novel and easily accessible indicator of hyperuricemia, potentially offering insights into its immunometabolic mechanisms for future research. However, further large-scale prospective studies are necessary to confirm this association.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251380995"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smoking exposure and cervical cancer risk: Integrating observational and genetic evidence. 吸烟暴露与子宫颈癌风险：综合观察和遗传证据。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 Epub Date: 2025-10-08 DOI: 10.1177/03000605251383687

Luyang Su, Ren Xu, Yanan Ren, Cuiqiao Meng, Pei Wang, Qi Wu, Liyun Song, Zeqing Du

{"title":"Smoking exposure and cervical cancer risk: Integrating observational and genetic evidence.","authors":"Luyang Su, Ren Xu, Yanan Ren, Cuiqiao Meng, Pei Wang, Qi Wu, Liyun Song, Zeqing Du","doi":"10.1177/03000605251383687","DOIUrl":"https://doi.org/10.1177/03000605251383687","url":null,"abstract":"ObjectiveTo investigate the relationship between smoking exposure and cervical cancer risk by integrating observational and genetic evidence.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (1999-2018) and performed a genetic instrumental variable analysis using genome-wide association studies data. Smoking exposure was assessed using self-reported status and serum cotinine concentrations. Logistic regression models were used to evaluate observational associations, while inverse variance weighting was used for genetic analysis.ResultsObservational analysis showed that current smokers had a significantly higher cervical cancer risk than nonsmokers and former smokers (adjusted odds ratio = 3.05, 95% confidence interval: 1.61-5.78, p < 0.001). Higher serum cotinine concentrations were also positively associated with cervical cancer risk. Genetic analysis further supported a causal link between smoking exposure and cervical cancer.ConclusionsSmoking exposure significantly increases cervical cancer risk, emphasizing the importance of smoking cessation for prevention of cervical cancer. Incorporating tobacco control into cervical cancer prevention strategies could reduce disease burden.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251383687"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

See more, treat early, conceive sooner: Outpatient hysteroscopy in modern fertility care. 多看，早治疗，早受孕：门诊宫腔镜在现代生育护理中的应用。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-10-01 Epub Date: 2025-10-09 DOI: 10.1177/03000605251384066

Gaetano Riemma, Salvatore Giovanni Vitale, Pasquale De Franciscis

引用次数: 0