Journal of International Medical Research最新文献

The interaction between nirmatrelvir/ritonavir and sirolimus: a case report of a kidney recipient with renal insufficiency and COVID-19.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241307845

Yinhua Gong, Dan Shen, Jinfang Shi, Ye Jiang, Jie Gao

引用次数: 0

Repeated Supera stent fracture following stenting for popliteal artery occlusion: a case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241308488

Byung Chan Lee, Chan Park, Hyoung Ook Kim, Ho Kyun Lee

{"title":"Repeated Supera stent fracture following stenting for popliteal artery occlusion: a case report.","authors":"Byung Chan Lee, Chan Park, Hyoung Ook Kim, Ho Kyun Lee","doi":"10.1177/03000605241308488","DOIUrl":"10.1177/03000605241308488","url":null,"abstract":"The popliteal artery segment is particularly challenging for endovascular treatment. Stents used for treating popliteal artery lesions are usually associated with an increased risk of stent fracture and re-occlusion. The Supera stent is designed to withstand mechanical stress, with a low risk of fracture. A man in his mid-70s with left popliteal artery occlusion was treated with a Supera stent implantation. After 5 months, he revisited our hospital complaining of left leg pain. Preprocedural computed tomography angiography showed popliteal artery occlusion associated with a Supera stent fracture. A new Supera stent was implanted at the previous stent fracture site. However, 3 months after the second procedure, computed tomography angiography showed popliteal artery re-occlusion associated with a repeated fracture of the Supera stent. A femoral-popliteal bypass was performed. At the 6-month follow-up, computed tomography angiography showed a patent graft. Our findings indicated that recurrent fractures occurred after additional Supera stenting at the previous Supera stent fracture site. Careful observation is necessary after deploying a new Supera stent for treating a Supera stent fracture because of the possibility of a repeated fracture.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241308488"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning to predict adverse drug events based on electronic health records: a systematic review and meta-analysis.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241302304

Qiaozhi Hu, Jiafeng Li, Xiaoqi Li, Dan Zou, Ting Xu, Zhiyao He

{"title":"Machine learning to predict adverse drug events based on electronic health records: a systematic review and meta-analysis.","authors":"Qiaozhi Hu, Jiafeng Li, Xiaoqi Li, Dan Zou, Ting Xu, Zhiyao He","doi":"10.1177/03000605241302304","DOIUrl":"10.1177/03000605241302304","url":null,"abstract":"Objective: This systematic review aimed to provide a comprehensive overview of the application of machine learning (ML) in predicting multiple adverse drug events (ADEs) using electronic health record (EHR) data.Methods: Systematic searches were conducted using PubMed, Web of Science, Embase, and IEEE Xplore from database inception until 21 November 2023. Studies that developed ML models for predicting multiple ADEs based on EHR data were included.Results: Ten studies met the inclusion criteria. Twenty ML methods were reported, most commonly random forest (RF, n = 9), followed by AdaBoost (n = 4), eXtreme Gradient Boosting (n = 3), and support vector machine (n = 3). The mean area under the summary receiver operator characteristics curve (AUC) was 0.76 (95% confidence interval [CI] = 0.26-0.95). RF combined with resampling-based approaches achieved high AUCs (0.9448-0.9457). The common risk factors of ADEs included the length of hospital stay, number of prescribed drugs, and admission type. The pooled estimated AUC was 0.72 (95% CI = 0.68-0.75).Conclusions: Future studies should adhere to more rigorous reporting standards and consider new ML methods to facilitate the application of ML models in clinical practice.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241302304"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic eosinophilia complicated with cryptococcal meningitis: a case report. 特发性嗜酸性粒细胞增多症并发隐球菌脑膜炎：病例报告。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241305437

Zhongshuo Liu, Ying Lou, Yingxiao Ji, Congying Zhao, Litao Li

引用次数: 0

Off-pump coronary artery bypass grafting versus percutaneous coronary intervention with second-generation drug-eluting stents for coronary artery revascularization.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241304545

Nan Li, Xin Xiong, Kun Yang, Yijun Xu, Zhiqiang Chen, Peng Liu, Wen Wen, Xiaowei Li, Jin Dong, Shoudong Wei, Durong Chen, Xiaolong Zhang, Dajiang Yuan, Yongzhi Deng

{"title":"Off-pump coronary artery bypass grafting versus percutaneous coronary intervention with second-generation drug-eluting stents for coronary artery revascularization.","authors":"Nan Li, Xin Xiong, Kun Yang, Yijun Xu, Zhiqiang Chen, Peng Liu, Wen Wen, Xiaowei Li, Jin Dong, Shoudong Wei, Durong Chen, Xiaolong Zhang, Dajiang Yuan, Yongzhi Deng","doi":"10.1177/03000605241304545","DOIUrl":"10.1177/03000605241304545","url":null,"abstract":"Objective: This study compared the clinical efficacy of off-pump coronary artery bypass grafting (OPCAB) with percutaneous coronary intervention (PCI) in the treatment of left main coronary artery and/or triple-vessel disease (LM and/or TVD).Methods: We retrospectively enrolled 1484 consecutive patients with LM and/or TVD in Shanxi Cardiovascular Hospital from January 2015 to December 2022 and divided them into the OPCAB group (n = 583) and the PCI group (with second-generation drug-eluting stents) (n = 901). Propensity score matching was used for 316 equally matched pairs of patients in the groups. The outcomes were all-cause and cardiac mortality, angina recurrence, and major adverse cardiac and cerebrovascular events, which comprised non-lethal myocardial infarction, stroke, and repeat revascularization.Results: The mean follow-up was 3.93 years in the OPCAB group and 4.19 years in the PCI group. There were no significant differences in all-cause mortality, cardiac mortality, major adverse cardiac and cerebrovascular events, or non-lethal myocardial infarction between the groups. The incidence of repeat revascularization and angina recurrence was higher in the PCI group than in the OPCAB group. However, the incidence of stroke was higher in the OPCAB group than in the PCI group.Conclusions: OPCAB may be a favorable coronary revascularization strategy for LM and/or TVD.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241304545"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAB32 promotes glioma cell progression by activating the JAK/STAT3 signaling pathway.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241282384

Sinan Zhang, Xudong Jiang, Qing Wei, Liji Huang, Zhuoyan Huang, Lina Zhang

{"title":"RAB32 promotes glioma cell progression by activating the JAK/STAT3 signaling pathway.","authors":"Sinan Zhang, Xudong Jiang, Qing Wei, Liji Huang, Zhuoyan Huang, Lina Zhang","doi":"10.1177/03000605241282384","DOIUrl":"10.1177/03000605241282384","url":null,"abstract":"Objective: This study aimed to investigate the role of RAB32 in glioblastomas and its molecular mechanisms that regulate gliomas.Methods: The expression and prognostic value of RAB32 were evaluated using western blotting and the Gene Expression Profiling Interactive, Chinese Glioma Genome Atlas, and The Cancer Genome Atlas databases. Lentivirus containing sh-RAB32 or OE-RAB32 was used to manipulate RAB32 expression in glioma cells. The effects of RAB32 on cell proliferation, migration, and invasion were determined by western blotting, cell counting kit-8, plate cloning, wound healing, and transwell assays. Gene set enrichment analysis was used to screen for associations between the JAK/STAT3 signaling pathway and RAB32. The role of this pathway was verified using JAK/STAT3 inhibitors.Results: RAB32 expression was significantly upregulated in patients with glioma and in glioma cell lines. The expression level was positively correlated with the glioma grade and served as an independent prognostic factor. In vitro experiments revealed that RAB32 knockdown inhibited glioblastoma cell proliferation, migration, and invasion, while the opposite effects were observed with overexpression and could be inhibited by the JAK/STAT3 inhibitor BP-1-102.Conclusion: RAB32 promotes malignant progression of glioblastoma cells through the JAK/STAT signaling pathway, providing new possibilities for therapeutic targets for glioblastoma.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241282384"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral refraction of young adults with myopia: a cross-sectional study.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241304586

Ali Alsaqr, Manal Alharbi, Noura Aldossary, Abdulaziz Alruwished, Mohammed Alharbi, Khalid Alghaib, Abeer Alabdulkarim, Alhamdan Shatha, Ali Abusharha

{"title":"Peripheral refraction of young adults with myopia: a cross-sectional study.","authors":"Ali Alsaqr, Manal Alharbi, Noura Aldossary, Abdulaziz Alruwished, Mohammed Alharbi, Khalid Alghaib, Abeer Alabdulkarim, Alhamdan Shatha, Ali Abusharha","doi":"10.1177/03000605241304586","DOIUrl":"10.1177/03000605241304586","url":null,"abstract":"Objective: Peripheral refraction is associated with myopia development. Due to a varying prevalence of myopia across different ethnic groups, the aim of the present study was to investigate the peripheral refraction profile in an Arabic population.Methods: Adults attending an optometry clinic were recruited into this cross-sectional study. Peripheral refraction of the right eyes was measured using an open field autorefractor under noncycloplegic conditions along the temporal-nasal meridians (15° and 35°) in participants with emmetropia, or low, moderate, or high myopia. Refractions were converted into power vector components, including the spherical equivalent of central refraction, J0 and J45 astigmatism. STROBE guidelines were followed for study reporting.Results: A total of 138 adults (aged 20-29 years) were enrolled. Relative peripheral refractive error (RPRE) varied between refractive groups and increased with eccentricity. The RPRE was more hyperopic in myopia groups, with the nasal visual field being more hyperopic. A significant relationship was found between RPRE and central refraction, but not with J0 and J45 scores.Conclusions: Participants with moderate myopia exhibited more hyperopic RPRE compared with previous findings in other ethnic groups. Hyperopic RPRE was significantly associated with myopia. Accurate RPRE measurement are essential for designing personalized lenses to slow down myopia progression. This study provides an RPRE baseline in the population investigated, which will be useful for future studies on personalized lens design, including spectacles and contact lenses.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241304586"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation analysis of serum inflammatory cytokine levels and immune markers in children with severe hand, foot and mouth disease.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241304636

Xiao Li, Qian Zhou

{"title":"Correlation analysis of serum inflammatory cytokine levels and immune markers in children with severe hand, foot and mouth disease.","authors":"Xiao Li, Qian Zhou","doi":"10.1177/03000605241304636","DOIUrl":"10.1177/03000605241304636","url":null,"abstract":"Objective: To identify the correlation between serum inflammatory cytokines and immune markers in children with severe hand, foot and mouth disease (HFMD).Methods: Paediatric patients with severe or mild HFMD from Linping Campus, the Second Affiliated Hospital of Zhejiang University, were included in this retrospective study. Data comprising demographic characteristics, clinical symptoms and signs, laboratory findings and other factors were collected. Serum interleukin (IL)-1, IL-6, IL-10, tumour necrosis factor (TNF)-α, and interferon (IFN)-γ levels were measured by enzyme-linked immunosorbent assay at 1, 3, and 5 days after admission. Risk factors were screened using multivariate logistic regression analysis.Results: A total of 200 patients with HFMD (120 severe and 80 mild cases) were included. Younger age and longer fever duration were associated with severe HFMD, as were increased white blood cell, neutrophil and platelet counts, blood glucose, immunoglobulin (Ig)M and IgG. IL-6 and IL-10 levels were higher in patients with severe versus mild HFMD on days 1, 3 and 5. TNF-α was higher in the severe group on day 3. Increased white blood cell and neutrophil counts, IL-6, IL-10, and IgG levels, age, fever duration, and blood glucose level were found to be risk factors associated with the occurrence of severe HFMD.Conclusions: Inflammatory cytokines and immune indexes may be related to the occurrence of severe HFMD.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241304636"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and effectiveness of ataluren in patients with Duchenne muscular dystrophy: single-center experience from Saudi Arabia.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241305252

Mushtaha Ahmad, Alaa ElRasoul, Raneem Sedayou, Mohammed Tamboosi, Hanan Mahroos, Shaimaa Alrashed, Mariam Tunkar, Faisal Alzahrani, Mohammed Alharbi, Mona Aljehani, Mousa Alahmari, Khalid Alqarni, Maha Gashlan, Berna Seker Yilmaz, Nahla M Alshaikh

{"title":"Safety and effectiveness of ataluren in patients with Duchenne muscular dystrophy: single-center experience from Saudi Arabia.","authors":"Mushtaha Ahmad, Alaa ElRasoul, Raneem Sedayou, Mohammed Tamboosi, Hanan Mahroos, Shaimaa Alrashed, Mariam Tunkar, Faisal Alzahrani, Mohammed Alharbi, Mona Aljehani, Mousa Alahmari, Khalid Alqarni, Maha Gashlan, Berna Seker Yilmaz, Nahla M Alshaikh","doi":"10.1177/03000605241305252","DOIUrl":"10.1177/03000605241305252","url":null,"abstract":"Objective: Duchenne muscular dystrophy (DMD) is a rare X-linked neurodegenerative disorder caused by mutations in the DMD gene. This study examined the efficacy and safety of ataluren, the first oral treatment for DMD with nonsense mutations (nmDMD), in patients in the Middle East.Methods: This retrospective longitudinal study assessed the outcomes of seven boys with nmDMD who received treatment with ataluren and follow-up at a single center since 2016.Results: The median patient age at treatment initiation was 8.04 years (range: 3.3-9.92), and the median duration of exposure was 3.95 years (interquartile range = 4.42 years). Five patients were still ambulatory at the last follow-up. Ataluren was more effective in individuals with baseline 6-min walking distance (6MWD) ≥300 m, as these patients had smaller declines in 6MWD and North Star Ambulatory Assessment scores. Pulmonary function was well preserved in all patients, with no patients having forced vital capacity <60% at their last follow-up. Six patients maintained normal cardiac function, whereas one patient developed heart failure before starting ataluren treatment.Conclusions: Our results demonstrated both the efficacy and safety of ataluren. Early initiation of ataluren treatment delayed the loss of ambulation and cardiorespiratory milestones.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241305252"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different doses of dexmedetomidine combined with propofol for older adults undergoing cardiac surgery: the impact on postoperative delirium.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-12-01 DOI: 10.1177/03000605241306579

Hong Wang, Hong Han, Yufang Leng, Jiaxi Yao

{"title":"Different doses of dexmedetomidine combined with propofol for older adults undergoing cardiac surgery: the impact on postoperative delirium.","authors":"Hong Wang, Hong Han, Yufang Leng, Jiaxi Yao","doi":"10.1177/03000605241306579","DOIUrl":"10.1177/03000605241306579","url":null,"abstract":"Objective: This study retrospectively investigated the effects of different doses of dexmedetomidine combined with propofol on postoperative delirium in older adults undergoing cardiac surgery.Methods: The medical records of 82 older adults undergoing cardiac surgery admitted to two hospitals between August 2019 and August 2022 were analyzed. The participants were divided into two groups based on the dexmedetomidine dose: group A (0.5 µg/kg dexmedetomidine + propofol) and group B (1.0 µg/kg dexmedetomidine + propofol). The mean arterial pressure (MAP), heart rate (HR), anesthesia depth index (NTI), and incidence of postoperative delirium (POD) at 7 days after surgery were compared.Results: MAP and HR were significantly higher in group A than in group B during extubation and 10 minutes after extubation and significantly higher than the values before anesthesia induction. At all time points post-anesthesia induction, NTI was higher in group B than in group A, and the incidence of POD within 7 days after surgery was significantly higher in group A. The Prince-Henry pain scores were higher in group A than in group B at 1, 4, 24, and 48 hours after surgery.Conclusions: Higher dexmedetomidine doses were associated with more stable hemodynamics and stronger effects on POD in older adults undergoing cardiac surgery.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 12","pages":"3000605241306579"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0