Journal of International Medical Research最新文献

{"title":"Dual antiplatelet therapy versus aspirin alone in acute ischemic stroke or transient ischemic attack: A meta-analysis and trial sequential analysis of randomized controlled trials.","authors":"Ramez M Odat, Sakhr Alshwayyat, Zainab I Bahdar, Mohammad Abdelraheem, Basma B Khalefa, Omar Jarah, Mohammad H Obeidat, Mohammad E Bani Khalaf, Aon J Bani Khalaf, Ayham Mohammad Hussein, Jehad A Yasin, Hamdah Hanifa, Hritvik Jain","doi":"10.1177/03000605251337035","DOIUrl":"10.1177/03000605251337035","url":null,"abstract":"<p><p>IntroductionData regarding the role of dual antiplatelet therapy in patients with ischemic stroke or transient ischemic attack are limited. This study aimed to systematically review and analyze the efficacy and safety of dual antiplatelet therapy compared with aspirin alone in patients with acute ischemic stroke or transient ischemic attack.MethodsWe searched PubMed, Embase, Scopus, Cochrane, and Web of Science databases from inception to August 2024 and identified randomized controlled trials comparing dual antiplatelet therapy with aspirin alone in patients with stroke. Pooled risk ratios with 95% confidence interval were calculated. Trial sequential analysis was conducted for the main outcomes to weigh the risks of type I and type II errors.ResultsFive studies involving 27,563 patients were included. Dual antiplatelet therapy was associated with a significantly reduced risk of recurrent ischemic stroke (risk ratio: 0.74, 95% confidence interval: 0.68-0.81) and major adverse cardiovascular events (risk ratio: 0.77, 95% confidence interval: 0.71-0.84). However, it was associated with a significantly higher risk of recurrent hemorrhagic stroke (risk ratio: 2.13, 95% confidence interval: 1.09-4.17) and bleeding (risk ratio: 2.21, 95% confidence interval: 1.48-3.32). Trial sequential analysis revealed that sufficient evidence for recurrent ischemic stroke, major adverse cardiovascular events, and bleeding was achieved.ConclusionDual antiplatelet therapy demonstrated a lower incidence of recurrent ischemic stroke and major adverse cardiovascular events compared with aspirin alone. However, further studies are warranted to provide sufficient evidence regarding recurrent hemorrhagic stroke and all-cause mortality.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337035"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous renal replacement therapy for severe transient hyperammonemia in a preterm infant weighing 1120 g: A case report.","authors":"Jinglin Xu, Jiahuai Liu, Hongyuan Yang, Weifeng Zhang, Dongmei Chen, Zhiyong Liu","doi":"10.1177/03000605251340556","DOIUrl":"10.1177/03000605251340556","url":null,"abstract":"<p><p>Transient hyperammonemia of the newborn is a rare form of hyperammonemia with an unclear, likely nongenetic etiology, primarily affecting larger preterm infants. However, lower birth weight and gestational age are associated with higher ammonia levels, increasing the risk of neurotoxicity and hepatotoxicity. Transient hyperammonemia of the newborn typically manifests as respiratory distress within the first 24 h post-birth, progressing to seizures and coma within 48 h. Continuous renal replacement therapy has demonstrated considerable efficacy in managing severe transient hyperammonemia of the newborn due to its high ammonia clearance rate; however, its application remains limited in very low birth weight preterm infants. Herein, we report the case of a male infant born at 28⁺² weeks gestation, weighing 1120 g, who developed transient hyperammonemia of the newborn 22 h post-birth. Despite initial pharmacotherapy and peritoneal dialysis, his ammonia levels continued to rise, necessitating continuous renal replacement therapy. After 42 h of continuous renal replacement therapy, his ammonia levels decreased significantly and he recovered fully, eventually being discharged in good health. This case highlights continuous renal replacement therapy as a viable, life-saving intervention for severe transient hyperammonemia of the newborn, even in very low birth weight preterm infants.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340556"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoadsorption combined with continuous venovenous hemodialyfiltration in a patient with <i>Escherichia coli</i> infection and severe diabetic ketoacidosis-associated rhabdomyolysis: A case report.","authors":"Xiaochun Zhou, Xu Li, Yingying Yang, Fang Wang, Ling Zhang, Ping Fu","doi":"10.1177/03000605251337905","DOIUrl":"10.1177/03000605251337905","url":null,"abstract":"<p><p>Herein, we present a rare and complex clinical case of a patient with urinary tract infection leading to ground <i>Escherichia coli</i> sepsis, severe diabetic ketoacidosis, and severe rhabdomyolysis. The patient was admitted to the hospital with fever, abnormal mental behavior, disturbances in the internal environment, and acute kidney injury and was thoroughly evaluated by physicians to determine the underlying causes of severe rhabdomyolysis, including <i>Escherichia coli</i> infection and metabolic disturbances. After treatment with rehydration resuscitation, anti-infective agents, and hemoadsorption combined with continuous venovenous hemodialyfiltration, the patient's condition improved, renal function was restored, and hemodialysis treatment was discontinued.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337905"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of delivery method on postnatal depression in Jordanian women: Insights from a cross-sectional survey.","authors":"Asma Basha, Hala Yousef, Roaa AlJazzazi, Joanna Alfugaha, Samah Alfreihat, Dunia Jaber, Kamel Jaber","doi":"10.1177/03000605251327485","DOIUrl":"https://doi.org/10.1177/03000605251327485","url":null,"abstract":"<p><p>ObjectivePostnatal depression is a common and serious mental health problem. Despite the existence of established risk factors for postnatal depression, the role of the mode of delivery in influencing its prevalence remains a topic of debate. This study investigated the potential association between postnatal depression and the mode of delivery, specifically comparing the prevalence of postnatal depression in women who had a vaginal delivery versus those who underwent either an emergency or elective cesarean section. This study aimed to explore how different modes of delivery affect the prevalence and severity of postnatal depression among women in Jordan.MethodsA cross-sectional study was conducted at Jordan University Hospital between January and April 2024 to assess postnatal depression among women who delivered singleton fetuses 1 week after delivery. The participants completed a self-reported questionnaire, which collected demographic data and responses to the Edinburgh Postnatal Depression Scale. These responses were used to evaluate postnatal depression symptoms.ResultsA total of 267 women participated in the study. Results showed no significant association or difference in the postnatal depression scores between different modes of delivery (p = 0.459 and 0.441). Moreover, gestational age at the time of delivery and the infant feeding method after delivery showed no significant differences in the postnatal depression scores (p = 0.681 and 0.537, respectively). Results showed that the occurrence of intrapartum complications was associated with an approximately two times greater risk of developing postnatal depression (adjusted odds ratio = 1.96, p = 0.013).DiscussionThis study found no clear relationship between the mode of delivery and postnatal depression, with similar depression scores observed across vaginal and cesarean deliveries. Peripartum complications were linked to a higher risk of postnatal depression, whereas factors such as age, occupation, and infant feeding method showed inconsistent associations. The results highlight the complex, multifactorial nature of postnatal depression.ConclusionsThere was no significant association or difference in the postnatal depression scores between the modes of delivery. The results suggested that factors other than the mode of delivery played a more significant role in the development of postnatal depression among the women included in this study. Although our findings contribute to the understanding of maternal mental health, further research is needed to explore additional risk factors and interventions for postnatal depression.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251327485"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and validation of a risk nomogram model for colorectal sessile serrated lesions.","authors":"Sihui Huang, Shiyu Liu, Fang Tan, Hu Chen, Guangxia Chen","doi":"10.1177/03000605251337577","DOIUrl":"10.1177/03000605251337577","url":null,"abstract":"<p><p>ObjectiveThis study aimed to explore the risk factors for colorectal sessile serrated lesions and construct a risk nomogram model.MethodsPatients were enrolled retrospectively from the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University from January 2019 to September 2023 and randomized to the training and validation sets at a ratio of 7:3. The predictors for constructing the nomogram model were screened via univariate analysis and multivariate logistic regression analysis. Subsequently, the performance of the model was evaluated.ResultsMultivariate logistic regression analysis revealed that age, history of smoking, history of alcohol consumption, and triglyceride-glucose index were independent risk factors for colorectal sessile serrated lesions (<i>p</i> < 0.05). The area under the curve values of the nomogram model in the training and validation sets were 0.715 (95% confidence interval: 0.676-0.753) and 0.742 (95% confidence interval: 0.669-0.815), respectively. The calibration curves showed good homogeneity between the predicted and actual values. Decision curve analysis showed that this nomogram model can achieve positive clinical benefits.ConclusionsAge, history of smoking, history of alcohol consumption, and triglyceride-glucose index are independent predictors of colorectal sessile serrated lesions. This nomogram model may predict the risk of colorectal sessile serrated lesions.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337577"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the Ilizarov method in treating complex nonunions of the lower limb long bones.","authors":"Ahmed Ibrahim Berzenji, Dedawan Namiq Rasul, Abdulkadr Muhammed S Alany","doi":"10.1177/03000605251337911","DOIUrl":"10.1177/03000605251337911","url":null,"abstract":"<p><p>BackgroundComplex nonunions of the lower limb long bones represent a challenging issue in orthopedics. Although the Ilizarov method is considered a successful treatment modality, its success varies with complications and patient-related factors.ObjectiveThis study aimed to evaluate the radiological and functional outcomes of the Ilizarov method in the management of complex nonunions of long bones. Specifically, we assessed bone healing, functional restoration, complication rates, and effectiveness of staged management strategies, including infection control and limb reconstruction.MethodsThis retrospective/prospective case series included 30 patients (31 nonunion cases) treated at three tertiary centers in Erbil city between 2020 and 2024. The patients underwent Ilizarov frame application following debridement and staged management for infection and bone transport. Outcomes were assessed using the Association for the Study and Application of the Method of Ilizarov criteria.ResultsThe union rate of the study cohort was 90.3%, with a mean treatment duration of 9.26 months. Functional outcomes were rated as excellent, good, and poor in 67.7%, 22.6%, and 6.5% of the cases, respectively. Common problems included pin tract infections (35.5%), limb length discrepancy (32.3%), and malalignment (9.7%).ConclusionAlthough the Ilizarov method yielded high union rates and satisfactory functional outcomes in complex nonunions, limb length discrepancies and pin tract infections remain critical issues. Optimizing rehabilitation, compliance, and surgical planning is crucial for improving long-term functional outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337911"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oxidative balance scores with the prevalence of prediabetes, impaired fasting glucose, and impaired glucose tolerance in the general US adult population: Evidence from NHANES 1999-2018.","authors":"Hongpeng Guo, Junjie Zhang, Ying Qi, Chenglin Sun, Ji Wu","doi":"10.1177/03000605251340616","DOIUrl":"https://doi.org/10.1177/03000605251340616","url":null,"abstract":"<p><p>ObjectiveOxidative stress likely contributes to the pathogenesis of prediabetes. The oxidative balance score is an emerging metric for quantifying exposure to dietary and lifestyle oxidative stress. This study aimed to investigate the association between oxidative balance score and the prevalence of prediabetes, impaired fasting glucose, and impaired glucose tolerance based on data from the National Health and Nutrition Examination Survey 1999-2018.MethodsIn this cross-sectional study, the oxidative balance score was derived from 16 dietary and 4 lifestyle components, as outlined in previous research. Prediabetes, impaired fasting glucose, and impaired glucose tolerance were diagnosed based on the American Diabetes Association criteria. Multivariate logistic regression models were employed to analyze these associations.ResultsIn total, 22,960 participants with a mean age of 44.7 years were included in this study. In fully adjusted models, dietary oxidative balance score, lifestyle oxidative balance score, and overall oxidative balance score were all inversely associated with the prevalence of prediabetes among the general US adult population (odds ratios and 95% confidence intervals of 0.956 (0.949, 0.963), 0.914 (0.891, 0.937), and 0.957 (0.950, 0.964), respectively; all p <0.0001). Compared with quartile 1, dietary oxidative balance score, lifestyle oxidative balance score, and overall oxidative balance score at quartile 4 were all associated with a significantly lower prevalence of prediabetes (odds ratios and 95% confidence intervals 0.515 (0.449, 0.591), 0.834 (0.740, 0.940), and 0.505 (0.440, 0.579), respectively; all p for trend <0.0001). Similar results were observed for impaired fasting glucose and impaired glucose tolerance. Restricted cubic spline analysis showed that most of the associations were nonlinear and that significant negative correlations were observed only after a certain threshold. Stratified and sensitivity analyses confirmed the robustness of the findings.ConclusionsAdherence to an antioxidant-rich diet and healthy lifestyle may aid in the prevention of prediabetes, impaired fasting glucose, and impaired glucose tolerance among the general US adult population. Further cohort studies are needed to validate these findings.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340616"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient osteoporosis of the hip and fatty liver disease: Case report and pathogenic hypothesis.","authors":"Marco Paoletta, Antimo Moretti, Sara Liguori, Francesca Gimigliano, Giovanni Iolascon","doi":"10.1177/03000605251334239","DOIUrl":"10.1177/03000605251334239","url":null,"abstract":"<p><p>Transient osteoporosis of the hip is a rare, temporary condition characterized by hip pain and functional limitations, which can significantly reduce the quality of life. Bone marrow edema of the proximal femur, identified through magnetic resonance imaging is the primary diagnostic feature of transient osteoporosis of the hip. While the exact cause of transient osteoporosis of the hip remains unclear, several potential pathophysiological mechanisms warrant further investigation to better understand this condition. In this case study, we present an unusual case of a patient with transient osteoporosis of the hip who was diagnosed with non-alcoholic fatty liver disease. A 42-year-old Caucasian man presented with left hip pain. After clinical and radiological evaluations, he was diagnosed with transient osteoporosis of the hip. Biochemical assessment revealed a persistent and isolated elevation of alanine aminotransferase. The patient underwent a treatment regimen involving 16 days of intramuscular neridronate along with physical therapy. At the 3- and 6-month follow-ups, he showed significant improvements in both clinical symptoms and radiological findings. In our study, we propose, for the first time, a potential association between liver disorders, specifically non-alcoholic fatty liver disease, and the onset of transient osteoporosis of the hip, exploring the possible pathophysiological mechanisms connecting these two conditions and discuss the rationale for both pharmacological and non-pharmacological treatments.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251334239"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case report: Bladder endometriosis at the urachus.","authors":"Jiale Deng, Guanqun Wang, Yu Yang, Mengying Liao, Liangkuan Bi, Benlin Wei","doi":"10.1177/03000605251340535","DOIUrl":"10.1177/03000605251340535","url":null,"abstract":"<p><p>Endometriosis is an uncommon condition, and its occurrence in the urachus is exceptionally rare. This case report highlights the extreme rarity of bladder endometriosis involving the urachal area. To the best of our knowledge, no such cases have been previously reported in the literature. The clinical presentation and imaging findings of this condition are extremely similar to those of urachal carcinoma, which makes the differential diagnosis particularly challenging. In this case, a 34-year-old woman presented with significant bladder irritative symptoms during menstruation. Imaging revealed a mass in the urachal region, but its characteristics remained uncertain. Cystoscopy showed only bladder compression, and the patient ultimately underwent robot-assisted laparoscopic partial cystectomy. Postoperative pathology confirmed the diagnosis of bladder endometriosis. This case underscores the importance of considering bladder endometriosis in the differential diagnosis of masses in the urachal area, particularly when they resemble urachal cancer. Early surgical intervention and histopathological confirmation are essential to prevent disease progression.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340535"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kimura's disease sequentially involving multiple sites in the head and neck: A case report with a 13-year follow-up and literature review.","authors":"Rui-Si Li, Xiang-Zi Zhang, Yu-Hua Quan, Yun-Ze Xuan","doi":"10.1177/03000605251337422","DOIUrl":"10.1177/03000605251337422","url":null,"abstract":"<p><p>Kimura's disease is a rare, chronic inflammatory condition with a high recurrence rate, primarily affecting young to middle-aged Asian males. It typically manifests as masses in the head and neck, accompanied with regional lymphadenopathy. This report describes the case of a 50-year-old man initially diagnosed with Kimura's disease 13 years ago, following surgical removal of a left submandibular mass. Subsequent recurrences involved the parotid and contralateral submandibular regions, requiring radiotherapy and intermittent oral prednisone therapy. After 6 years, he developed progressive proptosis and visual impairment, revealing multiple orbital masses bilaterally. A puncture examination of the left submandibular mass was indicative of Kimura's disease. Throughout the follow-up period, the eosinophil levels correlated with prednisone use. This case highlights the disease's capacity for multisite recurrence within the head and neck over an extended duration. The extensive orbital involvement without renal manifestations is a rare presentation. Long-term follow-up is crucial in Kimura's disease management, and oral prednisone can effectively control disease progression.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337422"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}