Journal of International Medical Research最新文献

{"title":"Pulmonary cement embolism: a rare complication of vertebroplasty.","authors":"Eirik Tjønnfjord, Ai Phi Thuy Ho, Dag Ottar Sætre, Nezar Raouf","doi":"10.1177/03000605241291447","DOIUrl":"10.1177/03000605241291447","url":null,"abstract":"<p><p>This comprehensive case study aimed to highlight the condition of pulmonary embolism (PE), which despite its relative obscurity, may be more common than initially assumed. PE frequently occurs in the Emergency Department. PE along with deep vein thrombosis are the two most prevalent forms of venous thromboembolism (VTE). VTE ranks as the third most common cardiovascular condition encountered in the Emergency Department, following heart attacks and strokes. Acknowledging the symptoms of VTE and acting on them early are important to prevent chronic manifestations and heart failure in some cases owing to persisting pulmonary hypertension. One of the most frequent causes of VTE is surgery, which often occurs owing to immobilization. However, in some cases, VTE is due to the procedure itself or due to what is used in the procedure or injected in the patient. We report the case of a patient who complained of dyspnea for some time before diagnostic steps were taken, such as computed tomography and echocardiography. This case report describes the complication of PE due to vertebroplasty, which is well described but underdiagnosed because it may not be considered. More focus on this complication during follow-up could help diagnose and treat patients more rapidly.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain abscess caused by <i>Mycobacterium tuberculosis</i> in an immunocompetent patient: a case report and literature review.","authors":"Keyin Chen, Xuan Leng, Hui Zhou","doi":"10.1177/03000605241291469","DOIUrl":"10.1177/03000605241291469","url":null,"abstract":"<p><p>Brain abscesses caused by <i>Mycobacterium tuberculosis</i> are rarely reported and are typically found in immunocompromised patients. The challenges in identifying the pathogen and the frequent delays in initiating appropriate therapy often result in a poor prognosis for patients. We herein report a rare case of a brain abscess caused by <i>M. tuberculosis</i> in a 63-year-old patient with a history of hypertension but no history of pulmonary tuberculosis. The patient was hospitalized twice because of worsening right upper limb weakness and speech difficulties. Both a pus culture and cerebrospinal fluid culture were negative. Ultimately, the diagnosis of <i>M. tuberculosis</i> infection was confirmed through next-generation sequencing and the tuberculosis-specific T-cell test (T-SPOT). The patient's symptoms improved following anti-tuberculosis treatment. This case highlights the importance of considering <i>M. tuberculosis</i> as a potential cause of brain abscesses, even in immunocompetent individuals, and underscores the need for early diagnosis for effective treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of repeated intra-articular administration of collagen as a treatment for knee osteoarthritis: a case report.","authors":"Yong In, Saad Mohammed Alshammari, Man Soo Kim","doi":"10.1177/03000605241291735","DOIUrl":"10.1177/03000605241291735","url":null,"abstract":"<p><p>Intra-articular injections aimed at correcting underlying pathophysiological processes and providing pain relief are essential for managing knee osteoarthritis (KOA). Collagen, the primary component of articular cartilage, has a long half-life, making it a promising candidate for intra-articular injections with a low risk of serious side effects. The first of the two cases in this report involved a woman in her early 70s with a 6-year history of persistent left knee pain. The second case involved a woman in her mid-50 s with a >7-year history of right knee pain. Both patients received hyaluronic acid injections every 6 months, totaling 10 injections over 5 years. They were diagnosed with Kellgren-Lawrence grade 2 KOA. The patients received two 3-mL intra-articular injections of 6% collagen, administered at baseline and 6 months later. Improvements in clinical outcomes, including visual analog scale scores and Western Ontario and McMaster Universities Osteoarthritis Index scores, were observed and maintained in both patients, with no side effects reported. In summary, when collagen injections were administered to these two patients with KOA, clinical improvements lasted approximately 6 months, and repeated treatments demonstrated efficacy and safety similar to the initial course.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjögren's syndrome positive for isolated anti-Ro52/SS-A antibody and anti-centromere antibody.","authors":"Hideki Nakamura, Masako Tsukamoto, Kinya Nagata, Yosuke Nagasawa, Kumiko Akiya, Hirotake Inomata, Masahiro Nishihara, Shin-Ya Asatani, Noboru Kitamura, Hisataka Kitano, Jun Shoji, Yu Iwabuchi, Toshiyuki Ishige, Hiroyuki Hao","doi":"10.1177/03000605241293986","DOIUrl":"10.1177/03000605241293986","url":null,"abstract":"<p><p>This current case report describes a Japanese woman in her 80s with xerostomia who presented with salivary gland dysfunction. She was positive for isolated anti-Ro52/SS-A antibody as determined by a chemiluminescent enzyme immunoassay and positive on a fluorescence enzyme immunoassay that recognizes both Ro52 and Ro60 antigens. A high serum concentration of anti-Ro52/SS-A antibody was determined by an enzyme-linked immunosorbent assay. A high anti-centromere antibodies (ACA) titre was also observed. Although Raynaud's phenomenon or a high serum immunoglobulin G concentration were not observed, Masson-trichrome staining of the patient's labial salivary glands showed considerable fibrosis. Her serum type I and type II interferon concentrations were normal. The present patient is the first with Sjögren's syndrome (SS) to exhibit isolated anti-Ro52/SS-A antibody and ACA without anti-Ro60/SS-A antibody. This current case report presents her case together with those of four other SS patients who were positive for isolated anti-Ro52/SS-A antibody. The SS literature also includes cases positive for ACA and describes clinical characteristics. The other four SS patients with isolated anti-Ro52/SS-A antibody described here had no ACA; interstitial pneumonia and polyneuropathy were observed in these cases, although there was no consistent tendency regarding types I and II interferon.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective cohort study on the association between nutritional status and prognosis in COVID-19 patients with severe and critical infection.","authors":"Shuangyun Gou, Dan Tang, Weiyi Li, Yu Qiu, Xiaoping Xu, Li Yang, Li Jiang","doi":"10.1177/03000605241292326","DOIUrl":"10.1177/03000605241292326","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between nutritional scoring systems, nutritional support methods, and the prognosis of severe and critically ill patients infected with the Omicron variant of coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>Patients with confirmed Omicron variant severe and critical COVID-19, who were admitted to Chongqing Medical University First Hospital between December 2022 and January 2023, were enrolled into this retrospective study. Clinical data of patients who survived for 28 days were compared with those who died during the same period. Nutritional status was assessed using the 2002 Nutrition Risk Screening (NRS) tool and Prognostic Nutritional Index (PNI). Factors influencing patient mortality were identified by multivariate logistic regression, and the relationship between patient nutrition and mortality as the disease progressed was illustrated using Kaplan-Meier curves. The study was registered on the ChiCTR platform (No. ChiCTR2300067595).</p><p><strong>Results: </strong>A total of 508 patients were included (349 survivors and 159 non-survivors). Significant differences were found in sex, age, NRS score, PNI score, albumin level, lymphocyte count, chronic comorbidities, mechanical ventilation, neutrophil count, procalcitonin, and platelet count between survivors and non-survivors. Multivariate analysis revealed that high NRS score (OR 3.87, 95% CI, 1.97, 7.63), fourth-level nutritional support (combined enteral and parenteral nutrition; OR 7.89, 95% CI, 1.32, 47.28), chronic comorbidities (OR 4.03, 95% CI, 1.91, 8.51), and mechanical ventilation (OR 6.03, 95% CI, 3, 12.13) were risk factors for mortality (OR > 1). The malnutrition rate among patients with NRS ≥ 3 was 41.93%. The median (interquartile range) PNI score was 38.20 (35.65, 41.25) for survivors versus 32.65 (29.65, 36.58) for non-survivors. The mortality rate was higher in patients with high nutritional risk within 28 days of hospitalization. The descending order for mortality rate in patients receiving different nutritional support was: dual parenteral and enteral nutrition, no nutritional intervention, single enteral nutrition, and single parenteral nutrition.</p><p><strong>Conclusion: </strong>A high proportion of severe and critically ill patients with COVID-19 experience malnutrition, and various factors are associated with their prognosis. High nutritional risk is significantly related to patient mortality. Early assessment using NRS or PNI is crucial for these patients, and personalized interventions should be implemented to improve overall nutritional status, maintain organ function, and enhance the body's antiviral defence.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desmin-related myopathy manifested by various types of arrhythmias: a case report and literature review.","authors":"Lu Geng, Mengxiao Wang, Keke Wang, Liang Xu, Jiaqi Li, Fan Liu, Jingchao Lu","doi":"10.1177/03000605241291741","DOIUrl":"10.1177/03000605241291741","url":null,"abstract":"<p><p>Desmin is a type III intermediate filament protein specifically expressed in muscle cells, which is encoded by the <i>DES</i> gene. Defects in the desmin protein and cytoskeletal instability may interfere with cardiac muscle conduction signals, a fundamental mechanism for arrhythmias in patients with desmin-related myopathy. This current case report presents a female patient in her early 20s who presented with early-onset complete atrioventricular block and complete left bundle branch block over the previous decade. More recently, she had developed ventricular tachycardia, ventricular fibrillation, atrial fibrillation and other arrhythmias. Echocardiography revealed non-compaction of the ventricular myocardium and pulmonary hypertension. Whole-exome sequencing analysis identified a heterozygous missense mutation in the <i>DES</i> gene: c.1216C>T (p.Arg406Trp). She was eventually diagnosed with arrhythmias due to desmin-related myopathy. A literature review of international databases was undertaken to summarise the clinical characteristics of the cardiac involvement associated with this <i>DES</i> gene mutation.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-132-3p downregulates <i>FOXO1</i> in CD4^<b>+</b> T cells and is associated with disease manifestations in patients with lupus.","authors":"Haihong Qin, Sunyi Chen, Xiao Liu, Jun Liang, Hao Wu, Xiaohua Zhu","doi":"10.1177/03000605241286762","DOIUrl":"10.1177/03000605241286762","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the expression status of miR-132-3p in CD4⁺ T cells in patients with systemic lupus erythematosus (SLE) and explore its potential role in SLE development.</p><p><strong>Methods: </strong>The study included 60 patients with SLE and 30 healthy controls. miR-132-3p expression in CD4⁺ T cells was detected by real-time quantitative reverse transcription polymerase chain. Bioinformatics analyses were employed to predict target genes and explore the potential role of miR-132-3p. The associations between miR-132-3p levels and SLE Disease Activity Index (SLEDAI) score, as well as laboratory characteristics, were analyzed.</p><p><strong>Results: </strong>miR-132-3p levels in CD4⁺ T cells were significantly higher in patients with SLE compared with healthy controls. Bioinformatics analysis identified <i>FOXO1</i> as a potential target gene of miR-132-3p, with a particular emphasis on the FOXO signaling pathway. miR-132-3p up-regulation in CD4⁺ T cells was associated with high SLEDAI score, high anti-double-stranded DNA levels, low C3 and C4 levels, positive anti-ribosomal P, and high 24-hour urinary protein levels in patients with SLE.</p><p><strong>Conclusions: </strong>miR-132-3p may contribute to CD4⁺ T cell dysregulation during SLE by targeting <i>FOXO1</i> and could potentially be used to assess disease severity.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11494630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous rupture of an unscarred uterus at the early third trimester due to placenta percreta: a case report.","authors":"Li Zhang, Xunyu Hong, Ling Hong","doi":"10.1177/03000605241281688","DOIUrl":"https://doi.org/10.1177/03000605241281688","url":null,"abstract":"<p><p>Uterine rupture during pregnancy is a complication of placenta percreta. We present the case of a woman in her early 30s with a history of incomplete abortion treated by dilatation and curettage who was admitted with abdominal pain and vomiting at 30 weeks of gestation. She was diagnosed with thrombophilia and was administered anticoagulant drugs. After 10 hours of monitoring, the patient abruptly deteriorated. An emergency cesarean delivery showed a ruptured uterus due to placenta percreta. She accepted localized excision and uterine repair, and recovered well. Rupture of an unscarred uterus due to placental percreta is an extremely rare obstetric complication with high maternal and fetal mortality. This condition should be suspected in all pregnant women who have severe abdominal pain without being in labor. The treatment of uterine rupture due to placental percreta should be individualized, and repair of the uterus is possible in the majority of women.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradoxical cerebral embolism three decades after mustard surgery in a patient with complete transposition of the great arteries: a case report.","authors":"Kosuke Matsuzono, Masayuki Suzuki, Takafumi Mashiko, Reiji Koide, Shigeru Fujimoto","doi":"10.1177/03000605241291753","DOIUrl":"10.1177/03000605241291753","url":null,"abstract":"<p><p>Atrial switch procedures such as the Mustard operation were previously popular for the complete transposition of the great arteries (i.e. dextro-transposition of the great arteries [d-TGA]). Patients with d-TGA who underwent atrial switch procedures approximately three decades ago have now entered adulthood. A female patient in her 30s with d-TGA had a paradoxical embolic stroke following the initiation of a low-dose oestrogen plus progesterone oral pill for dysmenorrhoea. She underwent Mustard surgery when she was 2 years old. Following a series of procedures including implantation of a permanent pacemaker that was required because of sinus node dysfunction, she had reached adulthood, was living by herself and working independently. One month after taking the low-dose oestrogen plus progesterone oral pill, venous thrombosis occurred in the left soleus and left peroneal veins; and she experienced an acute ischaemic stroke in the right middle cerebral artery area. Transoesophageal echocardiography revealed that the shunt was present only during the Valsalva manoeuvre. Based on the examinations, the patient was diagnosed with juvenile ischaemic stroke as a result of a paradoxical embolism. These findings suggest that paradoxical cerebral embolism can occur as a late complication in patients with d-TGA who underwent the Mustard operation as children.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retropharyngeal haematoma with subtotal upper airway obstruction after puncture attempt: a case report.","authors":"Jeanne Mallick, Max Guillot, Vincent Castelain, Antonin Michaud","doi":"10.1177/03000605241281665","DOIUrl":"10.1177/03000605241281665","url":null,"abstract":"<p><p>Mechanical complications during central catheterisation occur in approximately 15% of cases. This report describes a potentially fatal yet avoidable complication and highlights the typical radiological features of a retropharyngeal haematoma.A patient with acute myeloid leukaemia was admitted to the intensive care unit with respiratory distress immediately after an attempt to insert a subclavian catheter without ultrasound guidance. A computed tomography scan revealed nearly complete obstruction of the upper airway by a retropharyngeal haematoma, with a blush of contrast agent. There was also a mass effect on the trachea and mediastinal structures. The haematoma was caused by accidental puncture of the thyrocervical artery. The patient's condition improved following orotracheal intubation, transfusion of platelets and fresh frozen plasma, arterial radio-embolisation, and clinical monitoring of haematoma resorption, which restored airway patency.A retropharyngeal haematoma is a potentially lethal complication, and its treatment carries significant risks. Therefore, central catheter insertion should likely not be attempted without ultrasound guidance to avoid serious complications for patients.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}