Journal of International Medical Research最新文献

{"title":"Enterovirus D68 pneumonia in two older patients: A case report and literature review.","authors":"Weizhong Jin, Changcheng Shi, Yeping Li, Qingguo Wu","doi":"10.1177/03000605251359612","DOIUrl":"10.1177/03000605251359612","url":null,"abstract":"<p><p>Enterovirus D68 mainly causes respiratory tract infections, with children being the main infected population and most adults experiencing latent infections. This report presents the cases of two older patients with enterovirus D68 pneumonia. Both of them were diagnosed using next-generation sequencing, and one of them died of mediastinal emphysema despite undergoing various treatments. This report also reviewed the biological characteristics and epidemiological features of enterovirus D68 as well as the clinical diagnosis and treatment of the viral pneumonia. Currently, there are no specific antiviral drugs or vaccines, and the treatment mainly focuses on symptomatic support and anti-inflammatory therapy. Although there exists certain understanding of enterovirus D68 pneumonia, there are challenges in aspects such as a deeper understanding of the viral mechanism, development of drugs and vaccines, and optimization of diagnosis and treatment methods. Strengthening monitoring and health education is crucial for preventing and controlling the spread of this infection.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359612"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of stepping angiography and traditional segmental angiography in lower limb anterograde venography.","authors":"Hongzhi Sun, Lei Qi, Guoliang Wang, Huagang Li, Peng Ji, Maoneng Hu","doi":"10.1177/03000605251361099","DOIUrl":"https://doi.org/10.1177/03000605251361099","url":null,"abstract":"<p><p>ObjectiveTo compare the application value of stepping angiography and traditional segmental angiography in lower limb anterograde venography.MethodsA retrospective analysis was conducted among 95 patients who underwent lower limb anterograde venography at the Hefei Third People's Hospital and the First Affiliated Hospital of Anhui University of Chinese Medicine from September 2021 to December 2024. Among them, 50 patients who underwent traditional segmental angiography were assigned to the control group, while 45 patients who underwent stepping angiography were assigned to the observation group. Comparative assessments were performed between the two groups regarding image quality, angiography time, absorbed radiation dose, contrast agent dosage, and incidence of complications.ResultsThe image quality in the observation group was better than that in the control group. The average angiography time in the control group was 27.87 ± 4.98 min, while that in the observation group was 10.23 ± 2.88 min (<i>P </i>=<i> </i>0.013). The average absorbed radiation dose in the control group was 4.65 ± 1.32 Gy, while that in the observation group was 3.53 ± 0.73 Gy (<i>P </i>=<i> </i>0.008). The average contrast agent dosage in the control group was 69.42 ± 10.42 mL, while that in the observation group was 47.51 ± 8.14 mL (<i>P </i>=<i> </i>0.011). Two complications occurred in the control group, while three occurred in the observation group (<i>P </i>=<i> </i>0.339).ConclusionFor lower limb venous lesions, stepping angiography is superior to traditional segmental angiography in terms of overall image quality and practicality. Stepping angiography is a simpler and quicker process, and only a small dose of radiation is absorbed by both doctors and patients; moreover, it requires a lower dosage of contrast agent. It plays an important objective guiding role in the decision-making of treatment plans for lower limb venous diseases.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251361099"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke.","authors":"Zubing Xu, Linghong Guo, Yunqing Chen, Dandan Chen, Hudie Zhang, Xilin Xiong, Yan Gong, Qiulong Yu, Chenying Zeng, Lanjiao Zhang, Qin Huang, Jinchong Zhang, Keji Zou, Pu Fang, Daojun Hong, Jing Lin, Xian Liu, Xiaobing Li","doi":"10.1177/03000605251359474","DOIUrl":"https://doi.org/10.1177/03000605251359474","url":null,"abstract":"&lt;p&gt;&lt;p&gt;ObjectiveEndovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile recanalization. The present study aimed to identify the relationship between multiple inflammatory markers (before and after endovascular treatment) and futile recanalization.MethodsBetween November 2019 and September 2022, we retrospectively enrolled 456 patients according to the inclusion and exclusion criteria. Inflammatory variables, including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammation index, systemic inflammatory response index, systemic coagulation-inflammation index, and white blood cell count to mean platelet volume ratio, were collected.ResultsAmong the cohort of 456 patients, it was observed that 271 (59.4%) patients experienced futile recanalization. Univariate analysis revealed that patients with futile recanalization had higher neutrophil-to-lymphocyte ratio and systemic inflammatory response index but lower lymphocyte-to-monocyte ratio and systemic coagulation-inflammation index at admission compared with those without (p &lt; 0.05). Additionally, at postoperation, patients with futile recanalization had higher neutrophil-to-lymphocyte ratio, systemic inflammatory response index, and systemic immune-inflammation index but lower lymphocyte-to-monocyte ratio and systemic coagulation-inflammation index compared with those without (p &lt; 0.05). However, there were no significant differences in admission platelet-to-lymphocyte ratio, admission systemic immune-inflammation index, admission white blood cell count to mean platelet volume ratio, postoperation platelet-to-lymphocyte ratio, and postoperation white blood cell count to mean platelet volume ratio between the futile recanalization group and nonfutile recanalization group (p &gt; 0.05). Furthermore, multivariate logistic regression analysis showed that only admission systemic inflammatory response index, postoperation neutrophil-to-lymphocyte ratio, postoperation systemic inflammatory response index, and postoperation systemic immune-inflammation index remained significantly correlated with futile recanalization (p &lt; 0.05). Receiver operating characteristic curves revealed that postoperation neutrophil-to-lymphocyte ratio was the most predictive marker for futile recanalization (area under the curve = 0.623, 95% confidence interval: 0.572-0.675).ConclusionAdmission systemic inflammatory response index, postoperation neutrophil-to-lymphocyte ratio, postoperation systemic inflammatory response index, and postoperation systemic immune-inflammation index were independently associated with futile recanalization, and postoperation neutrophil-to-lymphocyte ratio may have the highest ability in predicting futile recanalization in patients who underwent endovascular trea","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359474"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal seizures associated with a rare familial 16p11.2 microduplication: A case report.","authors":"Jun Chen, Shaohua Bi, Juan Wang, Liying Dai","doi":"10.1177/03000605251358613","DOIUrl":"10.1177/03000605251358613","url":null,"abstract":"<p><p>The human 16p11.2 BP4-BP5 region, composed of low-copy repeats, is prone to mediating recurrent copy number variations that increase the risk of neurodevelopmental disorders. Compared with 16p11.2 deletion variants, duplication variants have lower penetrance and higher phenotypic heterogeneity. Due to limited perinatal data, early phenotypes warrant further investigation. We report the case of a neonate with seizures, microcephaly, and neurodevelopmental delay whose parents were phenotypically normal. Whole-exome sequencing revealed a 200.15-kb duplication in 16p11.2 seq[GRCh38]dup(16)(p11.2-p11.2) (chr16:29,963,728-30,168,686) in the proband and his mother, which was confirmed via quantitative polymerase chain reaction. This case highlights the potential link between 16p11.2 duplications and neonatal neurodevelopmental disorders, emphasizing the need for genetic counseling in affected families.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251358613"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>MTHFR</i> A1298C polymorphism and blood homocysteine levels with proteinuria in patients with type 2 diabetes mellitus.","authors":"Nga Thi Ngoc Pham, Thao Thai Thanh Le, Hoang Minh Phan, Hang Thi Thu Ho, Ha Hong Nguyen","doi":"10.1177/03000605251356008","DOIUrl":"10.1177/03000605251356008","url":null,"abstract":"<p><p>BackgroundA1298C polymorphism of the MTHFR gene and blood homocysteine levels are reported to be associated with the development of proteinuria in patients with type 2 diabetes mellitus; however, data remain limited.ObjectivesTo determine the characteristics of A1298C polymorphism and blood homocysteine levels as well as their association with proteinuria in patients with type 2 diabetes mellitus.Materials and methodsA cross-sectional study with convenient sampling was performed among patients with type 2 diabetes mellitus who visited the Can Tho University of Medicine and Pharmacy Hospital between August 2023 and August 2024. Blood samples were collected for genetic sequencing and homocysteine level testing. Proteinuria was defined as an albumin-to-creatinine ratio ≥30 mg/g.ResultsIn total, 192 patients with a mean age of 63.9 ± 13.1 years were enrolled. Males accounted for 34.9% of the study population. Analysis of A1298C polymorphism revealed genotype distributions of AA, AC, and CC genotypes as 51.6%, 41.1%, and 7.3%, respectively. A significant association was observed between A1298C polymorphism and elevated homocysteine levels, with CC genotype exhibiting a higher prevalence of hyperhomocysteinemia (28.6%) than AA (6.1%) and AC (22.8%) genotypes. Patients carrying AC+CC genotypes had a 2.40-fold higher risk of developing proteinuria (95% confidence interval: 1.30-4.41, p <<i> </i>0.05) than those with AA genotype. Elevated blood homocysteine levels were associated with an 8.98-fold increased risk of proteinuria (95% confidence interval: 2.06-39.11, p <<i> </i>0.05). Independent factors associated with proteinuria included age (odds ratio = 0.97), elevated homocysteine levels (odds ratio = 8.79), and AC+CC genotype (odds ratio = 2.08).ConclusionA1298C polymorphism was characterized by allele frequencies of 72.1% for A and 27.9% for C. In addition to age, the presence of the C allele and elevated blood homocysteine levels were identified as independent risk factors for proteinuria in patients with type 2 diabetes mellitus.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251356008"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of vertebroplasty versus posterior pedicle screw in treating stage III Kummell's disease without neurological deficits: A systematic review and meta-analysis.","authors":"Binbin Tang, Shengjia Hu, Yifeng Yuan, Hang Zhou, Xiaolin Shi","doi":"10.1177/03000605251353732","DOIUrl":"10.1177/03000605251353732","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the efficacy and safety of vertebroplasty versus posterior pedicle screw fixation combined with vertebroplasty in treating stage III Kummell's disease without neurological deficits.MethodA systematic literature search was conducted across six databases. A meta-analysis of prospective and retrospective studies meeting the inclusion criteria was conducted using Review Manager 5.4.1.ResultsEight studies (one prospective, one randomized control trial, and six retrospective) involving 409 patients were included. Vertebroplasty demonstrated advantages over posterior pedicle screw + vertebroplasty in operative time (weighted mean difference: -83.22 min; 95% confidence interval: -97.70 to -68.73; p<i> </i><<i> </i>0.05), blood loss (weighted mean difference: -158.65 mL; 95% confidence interval: -219.99 to -97.31; p<i> </i><<i> </i>0.05), and hospital stay (weighted mean difference: -5.64 days; 95% confidence interval: -7.36 to -3.92; p<i> </i><<i> </i>0.05). No significant differences were observed in Cobb's angle (weighted mean difference: 1.28°; 95% confidence interval: -0.21 to 2.78; p<i> </i>><i> </i>0.05), relative anterior vertebral height (weighted mean difference: 2.98%; 95% confidence interval: -4.15 to 10.11; p<i> </i>><i> </i>0.05), cement leakage (13.2% vs. 8.5%; odds ratios: 1.67; 95% confidence interval: 0.86-3.24; p<i> </i>><i> </i>0.05), or wound infection (0% vs. 4.88%; odds ratios: 0.28; 95% confidence interval: 0.07-1.15; p<i> </i>><i> </i>0.05).ConclusionBoth vertebroplasty and posterior pedicle screw + vertebroplasty are effective for treating stage III Kummell's disease without neurological deficits. Vertebroplasty offers superior perioperative outcomes with reduced surgical trauma and hospital stay.PROSPERO registration number: CRD420251031065.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251353732"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of TLR3 1337C/T and 1234C/T polymorphisms with chronic hepatitis B virus infection in Sudanese patients: A case-control study.","authors":"Khalid Elyass, Najem Aldin M Osman, Babbiker Mohammed Taher Gorish, Abdelsalam Ma Nail, Waha Ismail Yahia Abdelmula, Nadir Musa Khalil Abuzeid","doi":"10.1177/03000605251358062","DOIUrl":"https://doi.org/10.1177/03000605251358062","url":null,"abstract":"<p><p>ObjectiveThis study aimed to investigate the association of TLR3 single-nucleotide polymorphisms 1337 C/T (rs3775290) and 1234 C/T (rs3775291) with the risk of chronic hepatitis B virus infection.MethodsThis case-control study enrolled 136 participants (66 patients with chronic hepatitis B virus infection (cases) and 70 healthy controls). TLR3 polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Demographic/clinical data were collected via standardized questionnaires and analyzed using Statistical Package for Social Sciences (significance level: p < 0.05).ResultsFor TLR3 1337 C/T polymorphism, the CT genotype prevalence was significantly higher in cases (47.0%) than in controls (31.4%) (odds ratio = 0.42, 95% confidence interval: 0.20-0.87, p = 0.0187), while the CC genotype demonstrated protective effects (39.4% in cases vs. 62.9% in controls; odds ratio = 0.26, 95% confidence interval: 0.07-0.94, p = 0.0314). The C allele frequency showed significant between-group differences (odds ratio = 0.46, p = 0.0044). No associations were observed for 1234 C/T single-nucleotide polymorphism (p = 1.0). Biochemical analysis revealed significantly elevated alanine aminotransferase (p = 0.0044) and aspartate aminotransferase (p < 0.0001) levels in cases than in controls.ConclusionsRegarding TLR3 1337 C/T single-nucleotide polymorphism, the CT genotype increases the risk of chronic hepatitis B virus infection (odds ratio = 0.42), while the CC genotype demonstrates protective effects (odds ratio = 0.26) in Sudanese populations, suggesting its utility as a therapeutic target and prognostic marker. No 1234 C/T associations were observed.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251358062"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of systemic immune-inflammation index values and arthritis risk in adults.","authors":"Xuefei Xia, Yongyong Lou, Yu Zhou, Haoming Ling, Tingting Ge","doi":"10.1177/03000605251353037","DOIUrl":"10.1177/03000605251353037","url":null,"abstract":"<p><p>ObjectiveTo investigate the correlation between systemic immune-inflammation index (SII) values and the risk of arthritis among adult participants.MethodsCross-sectional data from adult participants (aged ≥18 years) in the National Health and Nutrition Examination Survey 2011-2018 dataset were utilized. The association between systemic immune-inflammation index values and arthritis risk was explored through multivariate regression and restricted cubic spline model-based analyses.ResultsAn analysis of categorical variables indicated that the risk of arthritis was significantly higher in the highest systemic immune-inflammation index quartile (Q4) compared with the lowest quartile (Q1; odds ratio = 1.36, 95% confidence interval = 1.23-1.51). Continuous variable and spline model analyses suggested that there was a significant and positive correlation between high systemic immune-inflammation index values and an increased risk of arthritis (odds ratio = 1.12, 95% confidence interval = 1.08-1.16, p < 0.001). A subgroup analysis revealed that this correlation was stronger in the older population than in the younger population (p interaction = 0.041). A sensitivity analysis suggested that the association between systemic immune-inflammation index values and arthritis risk was stable.ConclusionsOur research suggests a correlation between high systemic immune-inflammation index values and an increased risk of arthritis within the examined sample. Consequently, tracking systemic immune-inflammation index values could potentially facilitate the early detection of arthritis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251353037"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches.","authors":"Zhilin Xie, Yuanhao Li, Xiaoliu Li, Jing Zhang","doi":"10.1177/03000605251355996","DOIUrl":"10.1177/03000605251355996","url":null,"abstract":"<p><p>Diabetic sarcopenia is a common complication of diabetes, substantially impacting patients' quality of life and prognosis. Its pathogenesis is closely related to energy metabolism, with mitochondria-often referred to as the cellular \"powerhouse\"-playing a central role in this process. This review focuses on the role of mitochondrial dysfunction in diabetic sarcopenia, emphasizing mechanisms such as energy metabolism imbalance, oxidative stress-induced damage, and abnormalities in mitochondrial biogenesis and dynamics. Additionally, we discussed current research on diagnostic and therapeutic strategies targeting mitochondrial dysfunction. This narrative review aims to provide a theoretical foundation for a deeper understanding of the pathophysiology of diabetic sarcopenia and the development of novel therapeutic approaches.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251355996"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptococcal infection of the femur misdiagnosed as a primary bone tumor: A case report and literature review.","authors":"Bin Liu, Yiyun Ni, Haifeng Zeng, Min Tang, Junnan Jiang","doi":"10.1177/03000605251359432","DOIUrl":"https://doi.org/10.1177/03000605251359432","url":null,"abstract":"<p><p>Cryptococcal infections are uncommon, and musculoskeletal involvement of the femur is extremely rare, often resulting in diagnostic challenges. A woman in her early 70s presented with a 20-day history of progressive left thigh pain that was aggravated by limb movement. Initial evaluation at a local hospital suspected a primary bone tumor based on radiographic findings of an osteolytic lesion in the midshaft of the left femur. Laboratory tests revealed elevated C-reactive protein level, erythrocyte sedimentation rate, and ferritin levels, but no malignant tumor markers were detected. Radiological assessment, including magnetic resonance imaging and whole-body scintigraphy, raised the suspicion of a primary bone tumor, with differential diagnoses including eosinophilic granuloma or Brodie's abscess. An ultrasound-guided biopsy revealed spindle cell proliferation with multinucleated giant cells, with no evidence of malignancy. A multidisciplinary consultation attributed the finding to either an infectious etiology or a possible false-negative result of B-mode ultrasound-guided biopsy. The patient subsequently underwent debridement and biopsy of the affected bone in the left thigh. Although microbial cultures were negative, immunohistochemical analysis showed features consistent with cryptococcal infection. Special staining demonstrated the characteristic thick capsules of <i>Cryptococcus</i> spp., confirming the diagnosis of a cryptococcal granuloma in the left femur. Early diagnosis and timely treatment are important to effectively manage cryptococcal bone infections.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359432"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}