Journal of International Medical Research最新文献

Recurrent acute myocardial infarction associated with calcified pseudoaneurysm: A case analysis.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325180

Zhi-Ling Gao, Ping Xie, Xing Zhou, Yan-Ling Li

引用次数: 0

Assessing the diagnostic utility of cardiopulmonary exercise testing in evaluating coronary artery disease.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325170

Jianhua Xie, Yuan Liang, Xiaobo Huang, Yuxue Qin, Hai Huang, Jianxiong Liu

{"title":"Assessing the diagnostic utility of cardiopulmonary exercise testing in evaluating coronary artery disease.","authors":"Jianhua Xie, Yuan Liang, Xiaobo Huang, Yuxue Qin, Hai Huang, Jianxiong Liu","doi":"10.1177/03000605251325170","DOIUrl":"10.1177/03000605251325170","url":null,"abstract":"ObjectiveThis retrospective study aimed to investigate the correlation between the cardiopulmonary exercise test (CPET) and the severity of coronary stenosis (SYNTAX score) in patients with stable coronary artery disease (SCAD), thereby assessing CPET's diagnostic value.MethodsWe classified 220 patients who underwent coronary angiography into coronary heart disease (CHD) and non-CHD groups based on stenosis severity. Patients with SCAD were categorized into mild, moderate, and severe groups by the SYNTAX score. CPET was performed, and data on the general information, serological indicators, and echocardiographic parameters were collected. CPET parameters included oxygen uptake related to the work rate (△VO2/△WR), peak metabolic equivalent (Peak Mets), anaerobic threshold (AT), peak oxygen consumption per kilogram (PVO2/kg), and metabolic equivalent at anaerobic threshold (Met@AT).ResultsPatients without SCAD demonstrated significantly higher CPET parameters than those with SCAD. The CPET parameters varied significantly across severity groups in the SCAD group, with the mild group exhibiting higher values than the moderate and severe groups. No significant differences were observed in the baseline data between the groups or among patients with varying numbers of lesion branches.ConclusionCPET parameters demonstrated a significant negative correlation with the SYNTAX score in patients with SCAD, indicating its potential clinical value in assessing the severity of coronary stenosis and diagnosing SCAD.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325170"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embolic stroke complicating left ventricular thrombus in Takotsubo syndrome: A case report. Takotsubo 综合征左心室血栓并发栓塞性中风：病例报告。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-22 DOI: 10.1177/03000605251326764

Jingshu Lei, Lina Wang, Ningning Yin, Zhiqi Zhang

引用次数: 0

Case study: Acute plasmoblastic leukemia presentation following effective haploidentical hematopoietic stem cell transplantation therapy.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-28 DOI: 10.1177/03000605251326804

Azat Karabekov, Madina Abdirgalieva, Aigerim Najipova, Vadim Kemaykin, Olga Kolesnikova, Ruzal Vildanova, Almira Manatova, Zhuldyz Kuanysh

{"title":"Case study: Acute plasmoblastic leukemia presentation following effective haploidentical hematopoietic stem cell transplantation therapy.","authors":"Azat Karabekov, Madina Abdirgalieva, Aigerim Najipova, Vadim Kemaykin, Olga Kolesnikova, Ruzal Vildanova, Almira Manatova, Zhuldyz Kuanysh","doi":"10.1177/03000605251326804","DOIUrl":"10.1177/03000605251326804","url":null,"abstract":"Plasma cell leukemia is a rare and aggressive malignancy characterized by monoclonal gammopathy and the presence of circulating plasma cells in the peripheral blood. Therapeutic strategies for plasma cell leukemia remain undefined, with treatments primarily borrowed from those used in multiple myeloma. The first-line treatment typically involves a combination of a proteasome inhibitor, an immunomodulatory agent, steroids, and/or anthracyclines and alkylators within an intensive chemotherapy regimen. Following this, consolidation with autologous hematopoietic stem cell transplantation is offered to eligible patients, followed by maintenance therapy. For patients ineligible for autologous hematopoietic stem cell transplantation, allogeneic hematopoietic stem cell transplantation is considered a viable alternative. Given the challenges in securing a fully human leukocyte antigen-matched donor, haploidentical hematopoietic stem cell transplantation serves as a potential salvage therapy, as demonstrated in the clinical case presented. This article presents the case of a female patient in her 50s diagnosed with plasma cell leukemia who, following unsuccessful autologous hematopoietic stem cell mobilization, underwent haploidentical hematopoietic stem cell transplantation from her son, resulting in complete donor chimerism and a favorable response.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251326804"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple cardioembolic attacks with a huge ventricular thrombus in dilated cardiomyopathy: A case report and comprehensive review.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251324593

Maziar Moayerifar, Mani Moayerifar, Mahboobeh Gholipour, Pirouz Samidoust, Selvana Poursadrolah, Golshan Ghasemzadeh, Mahsa Radmoghadam

{"title":"Multiple cardioembolic attacks with a huge ventricular thrombus in dilated cardiomyopathy: A case report and comprehensive review.","authors":"Maziar Moayerifar, Mani Moayerifar, Mahboobeh Gholipour, Pirouz Samidoust, Selvana Poursadrolah, Golshan Ghasemzadeh, Mahsa Radmoghadam","doi":"10.1177/03000605251324593","DOIUrl":"10.1177/03000605251324593","url":null,"abstract":"Left ventricular thrombus is one of the major complications of dilated cardiomyopathy. Although the presence of a cardiac thrombus is a major risk factor for embolization, several probable conditions, the connection of which is not thoroughly studied, such as gout disease and methamphetamine abuse, are also possible causes. We present the case report of a male in his early 40s with a history of alcohol and methamphetamine abuse, gout, and dilated cardiomyopathy, experiencing multiple ischemic attacks, including acute limb ischemia, dysarthria, and renal infarct. Echocardiography revealed a large clot in the left ventricle. The patient received heparin at a rate of 1000 units/hour, followed by warfarin at 10 mg/day, and probenecid at 500 mg/day. The thrombus resolved upon anticoagulant therapy, with improvement in the patient's symptoms. Left ventricular thrombus formation in dilated cardiomyopathy is influenced by many factors, including drug toxicity (for instance, methamphetamine), uric acid levels, and N-terminal precursor B-type natriuretic peptide. The thrombus can cause cardioembolic attacks in multiple sites, and the choice for emergent therapy is an oral anticoagulant, which may improve the ejection fraction. However, certain aspects related to cardiac thrombosis and embolization risk still warrant more comprehensive studies.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251324593"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia. 评估调节性 T 细胞对发热性中性粒细胞减少症急性白血病患者生存结果的影响。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1177/03000605241276482

Sebnem Calik, Oktay Bilgir, İsmail Demir, Selma Tosun, Yeliz Özdemir

{"title":"Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia.","authors":"Sebnem Calik, Oktay Bilgir, İsmail Demir, Selma Tosun, Yeliz Özdemir","doi":"10.1177/03000605241276482","DOIUrl":"10.1177/03000605241276482","url":null,"abstract":"ObjectivesAcute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context.MethodsThis prospective observational, single-center study included 114 patients diagnosed with acute leukemia. Tregs percentages were measured using flow cytometry. Statistical analyses involved logistic regression to identify factors significantly associated with survival.ResultsOf the 114 patients, 78 recovered, while 36 died. The median Treg percentages were 5.9% in patients under 65 years and 5.38% in those 65 and older. A lower percentage of Tregs was associated with higher mortality in the older group (p = 0.04). Multivariate analysis highlighted the presence of comorbidities, documented infections, and day seven C-reactive protein levels as significant predictors of survival.ConclusionThis study supports the importance of monitoring chronic diseases and infection foci alongside traditional markers like C-reactive protein. Future research should explore the mechanistic roles of Tregs in immunosuppression and survival in this vulnerable population.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605241276482"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325162

Ayed A Dera

{"title":"Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance.","authors":"Ayed A Dera","doi":"10.1177/03000605251325162","DOIUrl":"https://doi.org/10.1177/03000605251325162","url":null,"abstract":"ObjectiveThe study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients.MethodsThis cross-sectional study conducted from January to April 2021 at the Prince Faisal Bin Khalid Cardiac Center, Abha, Saudi Arabia, examined cardiovascular and diabetic biomarkers, including HOMA-IR, in MI patients and controls to assess insulin resistance (IR), risk, and diagnostic accuracy.ResultsMI patients showed significantly elevated HOMA-IR, leptin, resistin, body mass index (BMI), and glucose-complexed hemoglobin (HbA1c) levels compared with controls in both genders (p < 0.0001). HbA1c was strongly associated with HOMA-IR, whereas age, BMI, leptin, and resistin showed weak correlations. Elevated HOMA-IR increased MI risk and demonstrated high diagnostic accuracy.ConclusionsElevated HOMA-IR was identified as an early indicator of the onset of MI, whereas serum leptin and resistin levels exhibited a positive association with IR in patients with MI. Moreover, serum leptin, resistin, and elevated HOMA-IR may independently contribute to the risk of MI.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325162"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staged intervention in a patient with concomitant giant abdominal aortic aneurysm and hepatic artery.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325165

Chunyan Zhu, Tong Zhou, Tudi Li, Rong Chen, Zhihuan Zeng

{"title":"Staged intervention in a patient with concomitant giant abdominal aortic aneurysm and hepatic artery.","authors":"Chunyan Zhu, Tong Zhou, Tudi Li, Rong Chen, Zhihuan Zeng","doi":"10.1177/03000605251325165","DOIUrl":"10.1177/03000605251325165","url":null,"abstract":"Abdominal aortic aneurysms are the most common types of aneurysms worldwide, whereas aneurysms in the blood vessels of the abdominal organs (splanchnic aneurysms) are rare. Few studies have reported cases of two giant aneurysms occurring simultaneously. Presented here is a case of a 67-year-old man who began to experience periumbilical pain with a diagnosis of a giant abdominal aortic aneurysm and a hepatic artery aneurysm. He was successfully treated using a staged endovascular stent grafting procedure. Postoperatively, the patient's abdominal pain was resolved, and he was prescribed medication for hypertension control, lipid control, heart rate control, antiplatelet therapy, and smoking cessation, which he took regularly. Follow-up evaluations were performed at 3, 6, and 9 months after surgery, and no late complications were observed. This case report suggests that when two giant aneurysms are diagnosed simultaneously, risk of rupture, surgical interventions, and postoperative complications are significantly increased. The choice of a treatment strategy is complex and has a high degree of individual specificity.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325165"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pan-immune-inflammation value and heart failure: Evidence from the NHANES 2011-2020.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325176

Chen Fu, Yijie Mao

{"title":"Association between pan-immune-inflammation value and heart failure: Evidence from the NHANES 2011-2020.","authors":"Chen Fu, Yijie Mao","doi":"10.1177/03000605251325176","DOIUrl":"10.1177/03000605251325176","url":null,"abstract":"ObjectiveThis study aimed to explore the association between pan-immune-inflammation value and heart failure outcomes using data from the nationally representative National Health and Nutrition Examination Survey database.MethodsWe conduct a cross-sectional cohort analysis using National Health and Nutrition Examination Survey data, including participants aged ≥20 years with available pan-immune-inflammation value data. We performed smooth curve fitting and threshold analysis, using both linear and non-linear regression models, to assess dose-response relationship and explore the continuous effect of pan-immune-inflammation value on heart failure outcomes.ResultsOur analysis revealed a significant and independent non-linear association between elevated pan-immune-inflammation value levels and an increased risk of heart failure occurrence. After adjustment for multiple covariates, these findings remained consistent and each increment unit in logarithmic pan-immune-inflammation value is associated with 34% increase in the risk of heart failure occurrence. Furthermore, we identified an inflection point of logarithmic pan-immune-inflammation value = 5.98 as a critical threshold. Stratified analyses revealed that the association between pan-immune-inflammation value and heart failure occurrence remains consistent across different subgroups.ConclusionsThis study confirmed the clinical value of pan-immune-inflammation value as a novel inflammatory biomarker in the assessment and monitoring of heart failure.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325176"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myoepithelioma-like hyalinizing epithelioid tumors of the palm: A case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251324492

Xiaoxiao Bao, Qianqian Lu, Bifei Huang, Xiaowei Zhang

{"title":"Myoepithelioma-like hyalinizing epithelioid tumors of the palm: A case report.","authors":"Xiaoxiao Bao, Qianqian Lu, Bifei Huang, Xiaowei Zhang","doi":"10.1177/03000605251324492","DOIUrl":"10.1177/03000605251324492","url":null,"abstract":"Myoepithelioma-like hyalinizing epithelioid tumors (MHETs) are distinct soft tissue neoplasms characterized by their unique histological presentation, including myoepithelioma-like hyalinization and an epithelioid-cell pattern. A defining molecular characteristic of these tumors is the presence of a novel OGT::FOXO gene fusion. Their distinct morphology makes diagnosis challenging because they can be mistaken for other soft tissue tumors. We report the case of a 71-year-old man who was admitted to our hospital with a 1-year history of a palpable mass on the left palm. Physical examination revealed a well-defined, mobile mass on the lateral aspect of the left palm, measuring 2.0 × 3.0 cm, with moderate consistency. The tumor was surgically excised, and postoperative pathology based on immunohistochemical staining and tissue morphology confirmed the diagnosis of MHET. The tumor cells exhibited diffuse positivity for CD34 and focal positivity for EMA. At the 3-month follow-up post-surgery, there was no evidence of recurrence or distant metastasis. MHETs are typically observed as superficial, well-circumscribed masses without the histological features of malignancy. Given the distinct tissue morphology and the recent identification of this tumor type, clinicians and pathologists must be aware of these features to facilitate accurate diagnosis and inform treatment strategies.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251324492"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0