Journal of International Medical Research最新文献

{"title":"Nonlinear association between the immunonutritional index hemoglobin, albumin, lymphocytes, and platelets score and hyperuricemia: A cross-sectional study involving 12,598 adults.","authors":"Manli Yan, Wenhua Shi, Haoyu Wang, Xiang Li","doi":"10.1177/03000605251380995","DOIUrl":"10.1177/03000605251380995","url":null,"abstract":"<p><p>BackgroundThe prevalence of hyperuricemia is increasing, posing a significant health concern, particularly in China, where it affects 13.3% of the population. Traditional nutritional perspectives do not fully explain hyperuricemia, and the relationship between immune status and hyperuricemia remains unclear.ObjectiveThis study aimed to examine the association between the immunonutritional index-hemoglobin, albumin, lymphocytes, and platelets (HALP) score-and hyperuricemia.MethodsIn this retrospective cross-sectional study, clinical data from 12,598 adults at Guangdong Provincial Hospital of Chinese Medicine were analyzed using SPSS and R.ResultsAmong the total participants, 3422 had hyperuricemia. Significant differences in immune-related indices were observed, with the HALP score showing a higher area under the curve (0.675, 95% confidence interval: 0.665-0.686) than traditional markers. HALP was significantly and nonlinearly associated with hyperuricemia risk, with an inflection point of 53.85. Below this threshold, each unit increase in HALP was associated with a 1.9% increase in risk (p < 0.001).ConclusionThis cross-sectional study identified a nonlinear association between the HALP score and the prevalence of hyperuricemia. These findings suggest that HALP serves as a novel and easily accessible indicator of hyperuricemia, potentially offering insights into its immunometabolic mechanisms for future research. However, further large-scale prospective studies are necessary to confirm this association.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251380995"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic blunt trauma causing fatal cardiac rupture and aortic dissection: A narrative review.","authors":"Ling Wang, Shitong Su, Lianjing Liang, Haifang Yu","doi":"10.1177/03000605251386164","DOIUrl":"https://doi.org/10.1177/03000605251386164","url":null,"abstract":"<p><p>Thoracic blunt injuries are not uncommon, and they can cause severe cardiac and major vascular damage, leading to high mortality. Blunt cardiac rupture and traumatic aortic dissection are the primary fatal outcomes of these injuries. Many patients do not survive long enough to reach the hospital, and even those who present to emergency departments face challenges in timely diagnosis and management. This narrative review was conducted in accordance with the core principles of the Scale for the Assessment of Narrative Review Articles. A literature search was performed to summarize current evidence on blunt cardiac rupture and traumatic aortic dissection in thoracic blunt trauma settings. Early recognition of life-threatening complications from thoracic blunt trauma is essential for prompt and accurate diagnosis as well as appropriate clinical interventions. Cardiac rupture and traumatic aortic dissection from thoracic blunt trauma have traditionally been considered distinct entities, exhibiting different injury mechanisms and clinical outcomes. This review provides a comprehensive overview of the etiology, injury mechanisms, diagnosis, and management of fatal cardiac rupture and aortic dissection resulting from thoracic blunt trauma. The review is limited by the scarcity of high-quality studies and the predominance of case reports, but it highlights critical patterns in diagnosis and management that may inform clinical practice and guide future research. Overall, the findings underscore that improved understanding and awareness of these conditions can facilitate earlier diagnosis and treatment, ultimately reducing mortality and improving patient care in real-world clinical settings.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251386164"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"See more, treat early, conceive sooner: Outpatient hysteroscopy in modern fertility care.","authors":"Gaetano Riemma, Salvatore Giovanni Vitale, Pasquale De Franciscis","doi":"10.1177/03000605251384066","DOIUrl":"10.1177/03000605251384066","url":null,"abstract":"","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251384066"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of admission biomarkers in predicting severe outcomes and triage in acute febrile illness: A cohort study.","authors":"Thejesh Srinivas, Nitin Gupta, Gagana Hanumaiah, Shwethapriya R, Prithvishree Ravindra, Kavitha Saravu, Ravindra Maradi, Souvik Chaudhuri","doi":"10.1177/03000605251375552","DOIUrl":"https://doi.org/10.1177/03000605251375552","url":null,"abstract":"<p><p>ObjectivesTo determine the role of biomarkers in acute febrile illness patients at admission in predicting moderate-to-severe multiorgan dysfunction at 24 h of hospitalization and the need for invasive mechanical ventilation at 48 h of hospitalization.MethodsThis prospective cohort study was conducted among 100 acute febrile illness patients brought to the emergency department. Biochemical and clinical parameters at hospital admission were recorded. The highest Sequential Organ Failure Assessment score was calculated at 24 h of hospitalization. The need for invasive mechanical ventilation at 48 h of hospitalization was evaluated.ResultsOf the 95 acute febrile illness patients, 60 (63.15%) had moderate-to-severe multiorgan dysfunction. Multivariable logistic regression showed that admission aspartate aminotransferase level ≥89 U/L (P < 0.001; area under the curve, 0.752), C-reactive protein level ≥161 mg/dL (P < 0.001; area under the curve, 0.751), and urea level ≥74 mg/dL (P < 0.001; area under the curve, 0.855) were independent predictors of moderate-to-severe multiorgan dysfunction at 24 h. Serum interleukin-6 level ≥84.48 pg/mL (P = 0.002; area under the curve, 0.728) on admission was an independent predictor of the need for invasive mechanical ventilation.ConclusionsUrea, aspartate aminotransferase, and C-reactive protein levels on admission may independently predict moderate-to-severe multiorgan dysfunction in acute febrile illness patients at 24 h of hospitalization. In addition, interleukin-6 level may be an independent predictor of the need for invasive mechanical ventilation at 48 h of hospitalization.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251375552"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiomyofibroblastoma of the scrotum: A report of two cases and literature review.","authors":"Qifan Xie, Chujin Ye, Hanzhong Chen, Zhiye Liu, Kun Wei, Fangqianyu Zhong, Xiaoyong Pu, Shang Huang","doi":"10.1177/03000605251386617","DOIUrl":"https://doi.org/10.1177/03000605251386617","url":null,"abstract":"<p><p>Angiomyofibroblastoma is a rare benign mesenchymal tumor typically found in the genital region of adult females, but its occurrence in the male scrotum is exceptionally uncommon. This report presents two cases of angiomyofibroblastoma in the male scrotum to enhance the understanding of this rare condition. In the first case, a man in his early 60s with a recent rectal cancer diagnosis was found to have a palpable right scrotal mass. Imaging suggested metastasis, but radical resection and pathological analysis confirmed angiomyofibroblastoma, with no evidence of testicular malignancy. The patient remained tumor-free for 7 years. In the second case, a man in his early 40s presented with a nontender, slowly enlarging right inguinal mass extending into the scrotum. Surgical resection revealed a 6 × 4-cm angiomyofibroblastoma, with no recurrence for 7 years. These cases underscore the importance of considering angiomyofibroblastoma in the differential diagnosis of scrotal masses in males. Accurate diagnosis relies on understanding the clinical, imaging, and histopathologic features of angiomyofibroblastoma to ensure appropriate management and favorable outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251386617"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the C-reactive protein-albumin-lymphocyte index and severity of acute coronary syndrome: A retrospective study.","authors":"Tingting Wu, Xin Zhao, Chenchen Tu, Xiantao Song, Qiumei Cao","doi":"10.1177/03000605251381579","DOIUrl":"10.1177/03000605251381579","url":null,"abstract":"<p><p>BackgroundThe C-reactive protein-albumin-lymphocyte index integrates inflammatory and nutritional markers. However, its role in acute coronary syndrome remains unclear.MethodsWe retrospectively analyzed 765 patients with acute coronary syndrome admitted to the Beijing Anzhen Hospital between January 2021 and December 2023. The C-reactive protein-albumin-lymphocyte index, neutrophil-to-lymphocyte ratio, C-reactive protein, and systemic immune-inflammation index were calculated from admission laboratories. Severe acute coronary syndrome was defined as ST-elevation myocardial infarction; mild acute coronary syndrome included non-ST-elevation myocardial infarction and unstable angina. Multivariable logistic regression was used to identify the predictors of severe acute coronary syndrome. Discriminative performance was assessed using receiver operating characteristic analysis with DeLong's test.ResultsLower C-reactive protein-albumin-lymphocyte index values were significantly associated with severe acute coronary syndrome (adjusted odds ratio: 0.91; 95% confidence interval: 0.86-0.95; p < 0.001) after adjustment for conventional risk factors. In receiver operating characteristic analysis, the C-reactive protein-albumin-lymphocyte index (area under the curve: 0.696; 95% confidence interval: 0.658-0.735) outperformed C-reactive protein (area under the curve: 0.599), neutrophil-to-lymphocyte ratio (area under the curve: 0.624), and systemic immune-inflammation index (area under the curve: 0.560) in discriminating severe from mild acute coronary syndrome (all p ≤ 0.001 for pairwise comparisons).ConclusionsThe C-reactive protein-albumin-lymphocyte index may help identify patients with more severe acute coronary syndrome and offers superior discrimination compared with established inflammatory and nutritional markers. Prospective studies are needed for validation.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251381579"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes-specific nutrition formulas on time in range in overweight or obese Colombian patients with diabetes: A case series study.","authors":"Ana-M Gomez, Maria-P Chicue, Diana-C Henao, Oscar-M Muñoz-Velandia","doi":"10.1177/03000605251382375","DOIUrl":"10.1177/03000605251382375","url":null,"abstract":"<p><p>The use of diabetes-specific nutrition formulas reduces postprandial glucose and insulin levels and promotes satiety, thereby improving glycemic control and contributing to weight loss. The effect of diabetes-specific nutrition formulas on the percentage of time in range (70-180 mg/dL) has not yet been investigated. This longitudinal pilot study was based on a case series of overweight or obese patients diagnosed with diabetes using continuous glucose monitoring and managed at the Hospital Universitario San Ignacio in Bogotá (Colombia). We compared continuous glucose monitoring data and anthropometric variables before and after 4 weeks of using a diabetes-specific nutrition formula as replacement for breakfast and afternoon snack. Eleven patients were included in this study; of these, 63.7% were men. The mean patient age was 55 ± 14.5 years, and 81.1% had type 2 diabetes. The mean percentage of time in range increased from 64% ± 24% to 75% ± 16% (mean difference: 10.63; 95% confidence interval: 2.13, 19.14; p = 0.01). The mean percentage of time above range (>180 mg/dL) decreased from 34% ± 25% to 23% ±14% (mean difference: -11.27; 95% confidence interval: -2.48, -20.05; p = 0.02), with no difference in hypoglycemia incidence or anthropometric variables. Our study suggests that the use of a diabetes-specific nutrition formula as replacement for breakfast and afternoon snack improves glycemic control, as measured via continuous glucose monitoring, in overweight or obese patients with type 2 diabetes. This adds to the emerging evidence on the effect of this intervention on continuous glucose monitoring metrics. Further evidence is needed from larger clinical trials to support the inclusion of this intervention in routine clinical practice.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251382375"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiopulmonary bypass-mediated lung ischemia-reperfusion injury: A protective role of sitaxentan.","authors":"Zhengjia Wang, Renshu Zhan, Liqun Mo, Yingying Zhang, Yirong Chen, Li Liu, Yiping Bai","doi":"10.1177/03000605251383318","DOIUrl":"10.1177/03000605251383318","url":null,"abstract":"<p><p>BackgroundCardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia-reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging. Sitaxentan, a selective endothelin receptor antagonist, has shown protective effects in ischemia-reperfusion models, suggesting its potential in mitigating lung ischemia-reperfusion injury. This study investigated the efficacy of sitaxentan in reducing lung ischemia-reperfusion injury during cardiopulmonary bypass.MethodsTwenty-four female beagles were divided into sham, cardiopulmonary bypass, and endothelin receptor antagonist (sitaxentan-treated) groups. Hemodynamics, arterial blood gas, lung damage scores, wet/dry ratio, and levels of various biomarkers were evaluated.ResultsLung damage scores in the endothelin receptor antagonist group were lower than those in the cardiopulmonary bypass group but higher than those in the sham group (<i>P</i> < 0.05). The wet/dry ratio was lowest in the sham group and higher in the cardiopulmonary bypass group than that in the endothelin receptor antagonist group (<i>P</i> < 0.05). Caspase-3 and hypoxia inducible factor-1α levels were intermediate in the endothelin receptor antagonist group compared with those in the cardiopulmonary bypass and sham groups (<i>P</i> < 0.05). In contrast, phosphorylated-endothelial nitric oxide synthase, phosphorylated protein kinase B, tumor necrosis factor-α, and interleukin-6 levels were higher in the endothelin receptor antagonist group than in the cardiopulmonary bypass and sham groups (<i>P</i> < 0.05). Malondialdehyde level was higher and superoxide dismutase level was lower in the cardiopulmonary bypass and endothelin receptor antagonist groups than in the sham group (<i>P</i> < 0.05).ConclusionsSitaxentan may offer a novel therapeutic approach to attenuate lung ischemia-reperfusion injury in clinical settings by regulating the hypoxia inducible factor-1α/phosphorylated protein kinase B/phosphorylated-endothelial nitric oxide synthase pathway.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251383318"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shear wave elastography in the differentiation of intra-abdominal hematoma and abscess.","authors":"Sercan Özkaçmaz, Mesut Özgökçe, Fatma Durmaz, Muhammed Bilal Akıncı, Muhammed Alpaslan, İlyas Dündar, Cemil Göya, Ayşe Özkaçmaz, Iskan Callı, Serhat Binici","doi":"10.1177/03000605251378696","DOIUrl":"10.1177/03000605251378696","url":null,"abstract":"<p><p>ObjectiveThe objective of this study was to examine the applicability of shear wave elastography as a quantitative approach for measuring tissue stiffness in the differentiation of intra-abdominal abscesses from hematomas, which share similar radiological findings.MethodsThis prospective single-center study included patients with intra-abdominal abscesses or hematomas who underwent shear wave elastography prior to ultrasound-guided drainage in an interventional radiology clinic between 2021 and 2022. An independent samples <i>t</i>-test was used to compare the mean shear wave velocity between the abscess and hematoma groups.ResultsA total of 50 patients (33 with abscesses and 17 with hematomas) were included in this study. The elastography values of the patients were expressed as mean ± standard deviation (minimum-maximum). The mean shear wave velocity of hematomas (1.11 ± 0.41 (0.54-1.98) m/s) was significantly higher than that of abscesses (0.68 ± 0.16 (0.36-1.07) m/s) (p < 0.001). In the receiver operating characteristic analysis, the area under the curve was 84.8%. When the optimal cutoff value was defined as 0.72, the sensitivity and specificity were 82.4% and 67%, respectively.ConclusionShear wave velocity can aid in differentiating intra-abdominal abscesses from hematomas using a simple and widely available method.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378696"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk analysis of cardiac disease mortality within 3 months in patients with lung cancer after surgery: A real-world cohort study.","authors":"Yimin Wu, Yun Cheng, Shuang Fu, Junbo Yuan, Jue Shen, Shunv Cai","doi":"10.1177/03000605251378947","DOIUrl":"10.1177/03000605251378947","url":null,"abstract":"<p><p>ObjectiveTo determine the 3-month heart disease-related mortality rate among patients with lung cancer who have undergone lobectomy and identify the common risk factors for mortality to provide a basis for clinical risk assessment and intervention strategies.MethodsWe conducted a retrospective cohort study using the Surveillance, Epidemiology, and End Results Program database (2010-2015), including 35,094 patients with stage I-III lung cancer who underwent surgery. Logistic regression analyzed mortality at 3, 7, and 11 months, focusing on non-cancer causes, particularly heart diseases.ResultsAmong the 35,094 patients, 3.24% (1138) died within 3 months, with heart disease accounting for 8.96% (102) of the deaths, a significantly higher percentage than that at 4-7 months (p = 0.017). Logistic regression analysis showed that several factors, including sex, age, postoperative radiotherapy, and postoperative systematic treatment were independent factors contributing to mortality owing to heart diseases within 3 months of surgery.ConclusionsIn this study, we analyzed the causes of early death in patients who had undergone lung cancer surgery and determined the independent risk factors associated with 3-month mortality due to heart disease in these patients.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378947"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}