Journal of International Medical Research最新文献_第2页

Prosthetic rehabilitation for bilateral transfemoral amputees using microprocessor-controlled knees with a novel training program: A study of two cases. 双侧经股截肢者采用微处理器控制膝关节与新型训练方案进行假肢康复：两例研究。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-06 DOI: 10.1177/03000605251346028

Mitsunori Toda, Takaaki Chin, Takashi Oshima, Izumi Takase, Yuji Azuma

{"title":"Prosthetic rehabilitation for bilateral transfemoral amputees using microprocessor-controlled knees with a novel training program: A study of two cases.","authors":"Mitsunori Toda, Takaaki Chin, Takashi Oshima, Izumi Takase, Yuji Azuma","doi":"10.1177/03000605251346028","DOIUrl":"10.1177/03000605251346028","url":null,"abstract":"The use of microprocessor-controlled prosthetic knees facilitates safe and efficient ambulation in individuals with unilateral transfemoral amputation, contributing to their reintegration into daily life. We report rehabilitation outcomes in two individuals with bilateral transfemoral amputations that used Kenevo (Ottobock, Germany), a microprocessor-controlled prosthetic knee designed for low-activity users (K1/K2), as the first prosthesis. Gait training began in the most stable mode (A) and then progressed to modes B, B+, or C depending on gait stability. One patient subsequently trained with C-Leg 4 (Ottobock), a higher-functioning microprocessor-controlled prosthetic knee (K3/K4). Training durations were 8 months (1 month pre-prosthetic, 3 months stubby, 3 months Kenevo, and 1 month C-Leg 4) and 12 months (1 month pre-prosthetic, 2 months stubby, and 9 months Kenevo). The longer duration was due to the patient having a short residual limb and difficulty with outdoor ambulation. Both patients achieved independent walking with C-Leg or Kenevo and maintained prosthetic walking in the community after discharge. Ten-meter walk speeds were 0.77 and 0.93 m/s; 6-minute walk distances were 365 and 332 m; oxygen uptakes were 21.0 and 37.1 mL/kg/min. These cases suggest that initial training with Kenevo may support efficient rehabilitation in bilateral transfemoral amputees, while residual limb length may influence oxygen uptake during prosthetic ambulation.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251346028"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mendelian randomization analysis of gut microbiota-driven immune modulation in rheumatoid arthritis: New mechanistic insights and therapeutic targets. 类风湿关节炎中肠道菌群驱动的免疫调节的孟德尔随机分析：新的机制见解和治疗靶点。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-20 DOI: 10.1177/03000605251349922

Huangsheng Tan, Xinhai Gao, Chengcai Dai, Pan Shen, Juyi Lai, Yuanfei Fu, Shenghua He

{"title":"Mendelian randomization analysis of gut microbiota-driven immune modulation in rheumatoid arthritis: New mechanistic insights and therapeutic targets.","authors":"Huangsheng Tan, Xinhai Gao, Chengcai Dai, Pan Shen, Juyi Lai, Yuanfei Fu, Shenghua He","doi":"10.1177/03000605251349922","DOIUrl":"10.1177/03000605251349922","url":null,"abstract":"ObjectiveTo explore the complex interactions between gut microbiota and immune cell phenotypes in rheumatoid arthritis development and identify potential therapeutic targets within the gut microbiota-immune cell axis.MethodsWe conducted a Mendelian randomization analysis to explore the causal relationship between gut microbiota and rheumatoid arthritis, including the role of immune cell mediators. Sensitivity analyses assessed pleiotropy and heterogeneity, while mediation analysis identified pathways through which immune cells mediate gut microbiota effects on rheumatoid arthritis development. Key microbial taxa and their effects on rheumatoid arthritis were quantified.ResultsOur analysis identified 27 gut microbiota taxa significantly associated with rheumatoid arthritis, with Provencibacterium massiliense showing the strongest protective effect (odds ratio = 0.807, 95% confidence interval: 0.700-0.911, P = 0.003). Additionally, 20 immune cell phenotypes with IgD+ CD38dim AC were significantly linked to rheumatoid arthritis (odds ratio = 1.064, 95% confidence interval: 1.027-1.102). Mediation analysis uncovered 13 significant gut microbiota-immune cell pathways, with the UBA8517-CCR2 monocyte pathway mediating 10.1% of the total effect (beta1 = -0.595, beta12 = 0.027, mediation proportion = 10.1%).ConclusionThis study offers novel insights into the gut microbiota-immune cell axis in rheumatoid arthritis, identifying Provencibacterium massiliense, IgD+ CD38dim AC and the UBA8517-CCR2 monocyte pathway as potential therapeutic targets for rheumatoid arthritis treatment.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251349922"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of sST2 with cardiovascular disease in maintenance hemodialysis patients: A systematic review and meta-analysis. 维持性血液透析患者sST2与心血管疾病的相关性：系统回顾和荟萃分析

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-06 DOI: 10.1177/03000605251345954

Ze Zhang, Tao Yang, Mengya Zhao, Huaqian Chen

{"title":"Association of sST2 with cardiovascular disease in maintenance hemodialysis patients: A systematic review and meta-analysis.","authors":"Ze Zhang, Tao Yang, Mengya Zhao, Huaqian Chen","doi":"10.1177/03000605251345954","DOIUrl":"10.1177/03000605251345954","url":null,"abstract":"BackgroundPrevious studies have shown that soluble growth-stimulated expression gene 2 protein (sST2) plays a significant role in the progression of maintenance hemodialysis. However, the relationship between sST2 and cardiovascular events in maintenance hemodialysis patients remains largely understudied.MethodThis study systematically searched PubMed, Wanfang, and other Chinese and English databases for all published studies on sST2 in maintenance hemodialysis. Relevant literature meeting the requirements was screened, and relevant data were extracted accordingly. The Newcastle-Ottawa Scale was used to evaluate the quality of the selected studies. Publication bias was assessed via funnel plots and Egger's test. A meta-analysis was performed using either a random-effects or fixed-effects model, as appropriate.ResultsA total of 10 high-quality studies were included in this study, with no significant publication bias. The meta-analysis revealed that sST2 level was associated with the incidence of cardiovascular events in maintenance hemodialysis patients (mean difference = 18.89, 95% confidence interval: 13.93-23.84; p < 0.001). Moreover, elevated sST2 levels were correlated with a higher risk of cardiovascular events (odds ratio = 2.89, 95% confidence interval: 1.71-4.89; p < 0.0001).ConclusionsST2 may serve as a predictive biomarker for cardiovascular events in maintenance hemodialysis patients.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251345954"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Ventricular fibrillation likely resulting from electrocautery and amiodarone: a rare clinical case report". 对“可能由电灼和胺碘酮引起的心室颤动：一个罕见的临床病例报告”的更正。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-05 DOI: 10.1177/03000605251349601

引用次数: 0

Surgical smoke-related occupational injuries among medical professionals in the operating room. 手术室医务人员手术吸烟相关的职业伤害。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1177/03000605251347553

Chen Fengxia, Dexiang Jin, Ailing Lian

{"title":"Surgical smoke-related occupational injuries among medical professionals in the operating room.","authors":"Chen Fengxia, Dexiang Jin, Ailing Lian","doi":"10.1177/03000605251347553","DOIUrl":"10.1177/03000605251347553","url":null,"abstract":"ObjectiveThe use of energy devices during surgery can cause the spread of surgical smoke into the operating room. The concentration of smoke particles during laparoscopic surgery is higher than that during open surgery. This study aimed to quantify polycyclic aromatic hydrocarbons during laparoscopic surgery and evaluate the carcinogenic risks to healthcare workers, as the current relevant data are insufficient.MethodsThis prospective observational study collected and classified surgical smoke generated during laparoscopic surgery. Quantitative and qualitative analyses of polycyclic aromatic hydrocarbons were performed using gas chromatography-mass spectrometry.ResultsMultiple types of polycyclic aromatic hydrocarbons were generated during laparoscopic surgery. The polycyclic aromatic hydrocarbon concentrations remained below the carcinogenic risk levels in both laparoscopic liver cancer surgery and rectal cancer resection procedures.ConclusionThe deposition pattern and concentration of polycyclic aromatic hydrocarbons generated during laparoscopic liver and rectal cancer resection surgeries in the human respiratory tract are different. The potential toxicity of polycyclic aromatic hydrocarbons in the smoke to the health of healthcare workers should not be ignored.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251347553"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond barriers: The role of preexposure prophylaxis in the prevention of human immunodeficiency virus in women. 超越障碍：暴露前预防在预防妇女人体免疫缺陷病毒中的作用。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1177/03000605251337427

Alex Dang, Hillary Debs, Johnny Ruiz, Amber Vu, Melissa E Badowski

{"title":"Beyond barriers: The role of preexposure prophylaxis in the prevention of human immunodeficiency virus in women.","authors":"Alex Dang, Hillary Debs, Johnny Ruiz, Amber Vu, Melissa E Badowski","doi":"10.1177/03000605251337427","DOIUrl":"10.1177/03000605251337427","url":null,"abstract":"Preventive measures for human immunodeficiency virus infection have greatly evolved with the approval of preexposure prophylaxis. Despite their effectiveness, a significant gap exists in the initiation and adherence to these preventive measures among cisgender women. This review aims to highlight available implementation models to increase preexposure prophylaxis use and adherence in this population. A narrative review was conducted to identify studies focusing on preexposure prophylaxis use among cisgender women. Ultimately, 15 studies were included and categorized based on their intervention type: behavioral, health clinic, community, pharmacy, technology, or mobile. This review identified several intervention models that improved preexposure prophylaxis use and adherence among cisgender women. Behavioral interventions, such as preexposure prophylaxis-trained nurses and combined counseling with short message service reminders, significantly improved adherence. Health clinic-based interventions demonstrated the importance of regular follow-up and the potential for improved adherence through injectable preexposure prophylaxis. Community interventions highlighted the effectiveness of referral systems and technology-driven approaches, including mHealth interventions and real-time electronic adherence monitoring, to promote preexposure prophylaxis uptake and adherence. Implementing diverse interventions may considerably improve adherence and reduce the human immunodeficiency virus transmission rates in this population.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251337427"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of portal venous gas caused by the use of a nasojejunal nutrition tube. 应用鼻空肠营养管致门静脉气体1例。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1177/03000605251340529

Youshun Liu, Yong Li, Chunping Zhu, Haifeng Liu, Ji Huang

{"title":"A case of portal venous gas caused by the use of a nasojejunal nutrition tube.","authors":"Youshun Liu, Yong Li, Chunping Zhu, Haifeng Liu, Ji Huang","doi":"10.1177/03000605251340529","DOIUrl":"10.1177/03000605251340529","url":null,"abstract":"We reported a case of portal vein pneumatosis caused by a nasojejunal nutrition tube that was successfully treated conservatively. This patient was discharged after 1 week of treatment with imipenem/cilastatin sodium for anti-infection, gastrointestinal decompression, fluid replacement, and pain relief, and the patient's abdominal pain was significantly relieved. The main pathogenesis of hepatic portal venous gas is as follows: (a) increased pressure in the digestive tract leading to gas entering the portal vein circulation through the intestinal wall and finally into the liver; (b) destruction of the intestinal mucosa causing the gas formed by intestinal bacteria to enter the portal vein system; and (c) diffusion of gas produced by bacteria in intraperitoneal abscesses or portal vein and mesentery, causing pyelitis. The successful treatment of this patient highlights that addressing physical factors, providing gastrointestinal decompression, and administering anti-infection therapy can aid in the management of such cases. Bacterial culture of gastric juice and drug sensitivity testing can guide effective anti-infection treatment.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251340529"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: "Possible involvement of the Hedgehog and PDPK1-Akt pathways in the growth and migration of small-cell lung cancer". 撤回：“Hedgehog和PDPK1-Akt通路可能参与小细胞肺癌的生长和迁移”。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-20 DOI: 10.1177/03000605251352928

引用次数: 0

Mechanism of umbilical cord mesenchymal stem cells in the expansion of umbilical cord blood-derived hematopoietic stem cells in vitro. 脐带间充质干细胞在体外培养脐血源性造血干细胞中的作用机制。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-24 DOI: 10.1177/03000605251350968

Zhuo-Yang Bian, Li Xu

{"title":"Mechanism of umbilical cord mesenchymal stem cells in the expansion of umbilical cord blood-derived hematopoietic stem cells in vitro.","authors":"Zhuo-Yang Bian, Li Xu","doi":"10.1177/03000605251350968","DOIUrl":"10.1177/03000605251350968","url":null,"abstract":"The methodologies and applications of ex vivo expansion of umbilical cord blood cells represent a significant research domain, primarily owing to the distinctive characteristics of these cells and their prospective uses in regenerative medicine and hematopoietic stem cell transplantation. We searched PubMed and Web of Science using the terms \"umbilical cord blood cells,\" \"cytokine,\" \"haematopoietic cells,\" \"umbilical cord mesenchymal stem cells,\" \"in vitro expansion,\" and \"microenvironment,\" and the selected literature was organized and analyzed. We present a narrative review of the mechanisms by which umbilical cord mesenchymal stem cells enhance the in vitro expansion of umbilical cord blood-derived hematopoietic stem cells, focusing on three primary aspects: secretion of diverse cytokines to replicate the natural hematopoietic microenvironment, transmission of critical signals via direct cell-to-cell contact, and exertion of immunomodulatory effects to alleviate environmental stress. Although these processes can significantly promote the proliferation and survival of hematopoietic stem cells, the challenge of concurrently preserving the long-term stemness of these cells in an in vitro environment remains a critical issue for future research.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251350968"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in drug-coated balloons for the treatment of coronary artery de novo large-vessel lesions. 药物包被球囊治疗冠状动脉新生大血管病变的进展。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-06-01 Epub Date: 2025-06-28 DOI: 10.1177/03000605251342671

Lizhi Lin, Xiaorong Yin, Meng Chen, Lu Cui, Cheng Shen, Yong Cao

{"title":"Advances in drug-coated balloons for the treatment of coronary artery de novo large-vessel lesions.","authors":"Lizhi Lin, Xiaorong Yin, Meng Chen, Lu Cui, Cheng Shen, Yong Cao","doi":"10.1177/03000605251342671","DOIUrl":"https://doi.org/10.1177/03000605251342671","url":null,"abstract":"The incidence and mortality of coronary heart disease are increasing annually, and the disease is now one of the leading causes of death in China. Percutaneous coronary intervention has become the preferred approach for treating coronary artery disease. The use of a drug-coated balloon is a new treatment strategy for coronary artery disease that has been shown to be safe and effective in intravascular restenosis, bifurcation disease, and small-vessel disease, and this approach has been extended to other indications, such as large-vessel coronary artery disease. However, some experts believe that the intima muscularis fibrosa of large vessels is thick. After dilation of large vessels with drug-coated balloons, elastic contraction may occur. Additionally, the use of drug-coated balloons cannot prevent the occurrence of vessel dissection; therefore, their use for treating large-vessel coronary disease remains controversial. This review has aimed to discuss the findings of clinical trials demonstrating the efficacy and safety of drug-coated balloons for the treatment of coronary artery de novo large-vessel lesions.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251342671"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0