Journal of International Medical Research最新文献_第2页

Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325162

Ayed A Dera

{"title":"Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance.","authors":"Ayed A Dera","doi":"10.1177/03000605251325162","DOIUrl":"https://doi.org/10.1177/03000605251325162","url":null,"abstract":"ObjectiveThe study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients.MethodsThis cross-sectional study conducted from January to April 2021 at the Prince Faisal Bin Khalid Cardiac Center, Abha, Saudi Arabia, examined cardiovascular and diabetic biomarkers, including HOMA-IR, in MI patients and controls to assess insulin resistance (IR), risk, and diagnostic accuracy.ResultsMI patients showed significantly elevated HOMA-IR, leptin, resistin, body mass index (BMI), and glucose-complexed hemoglobin (HbA1c) levels compared with controls in both genders (p < 0.0001). HbA1c was strongly associated with HOMA-IR, whereas age, BMI, leptin, and resistin showed weak correlations. Elevated HOMA-IR increased MI risk and demonstrated high diagnostic accuracy.ConclusionsElevated HOMA-IR was identified as an early indicator of the onset of MI, whereas serum leptin and resistin levels exhibited a positive association with IR in patients with MI. Moreover, serum leptin, resistin, and elevated HOMA-IR may independently contribute to the risk of MI.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325162"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staged intervention in a patient with concomitant giant abdominal aortic aneurysm and hepatic artery.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325165

Chunyan Zhu, Tong Zhou, Tudi Li, Rong Chen, Zhihuan Zeng

{"title":"Staged intervention in a patient with concomitant giant abdominal aortic aneurysm and hepatic artery.","authors":"Chunyan Zhu, Tong Zhou, Tudi Li, Rong Chen, Zhihuan Zeng","doi":"10.1177/03000605251325165","DOIUrl":"10.1177/03000605251325165","url":null,"abstract":"Abdominal aortic aneurysms are the most common types of aneurysms worldwide, whereas aneurysms in the blood vessels of the abdominal organs (splanchnic aneurysms) are rare. Few studies have reported cases of two giant aneurysms occurring simultaneously. Presented here is a case of a 67-year-old man who began to experience periumbilical pain with a diagnosis of a giant abdominal aortic aneurysm and a hepatic artery aneurysm. He was successfully treated using a staged endovascular stent grafting procedure. Postoperatively, the patient's abdominal pain was resolved, and he was prescribed medication for hypertension control, lipid control, heart rate control, antiplatelet therapy, and smoking cessation, which he took regularly. Follow-up evaluations were performed at 3, 6, and 9 months after surgery, and no late complications were observed. This case report suggests that when two giant aneurysms are diagnosed simultaneously, risk of rupture, surgical interventions, and postoperative complications are significantly increased. The choice of a treatment strategy is complex and has a high degree of individual specificity.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325165"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between pan-immune-inflammation value and heart failure: Evidence from the NHANES 2011-2020.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251325176

Chen Fu, Yijie Mao

{"title":"Association between pan-immune-inflammation value and heart failure: Evidence from the NHANES 2011-2020.","authors":"Chen Fu, Yijie Mao","doi":"10.1177/03000605251325176","DOIUrl":"10.1177/03000605251325176","url":null,"abstract":"ObjectiveThis study aimed to explore the association between pan-immune-inflammation value and heart failure outcomes using data from the nationally representative National Health and Nutrition Examination Survey database.MethodsWe conduct a cross-sectional cohort analysis using National Health and Nutrition Examination Survey data, including participants aged ≥20 years with available pan-immune-inflammation value data. We performed smooth curve fitting and threshold analysis, using both linear and non-linear regression models, to assess dose-response relationship and explore the continuous effect of pan-immune-inflammation value on heart failure outcomes.ResultsOur analysis revealed a significant and independent non-linear association between elevated pan-immune-inflammation value levels and an increased risk of heart failure occurrence. After adjustment for multiple covariates, these findings remained consistent and each increment unit in logarithmic pan-immune-inflammation value is associated with 34% increase in the risk of heart failure occurrence. Furthermore, we identified an inflection point of logarithmic pan-immune-inflammation value = 5.98 as a critical threshold. Stratified analyses revealed that the association between pan-immune-inflammation value and heart failure occurrence remains consistent across different subgroups.ConclusionsThis study confirmed the clinical value of pan-immune-inflammation value as a novel inflammatory biomarker in the assessment and monitoring of heart failure.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325176"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myoepithelioma-like hyalinizing epithelioid tumors of the palm: A case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1177/03000605251324492

Xiaoxiao Bao, Qianqian Lu, Bifei Huang, Xiaowei Zhang

{"title":"Myoepithelioma-like hyalinizing epithelioid tumors of the palm: A case report.","authors":"Xiaoxiao Bao, Qianqian Lu, Bifei Huang, Xiaowei Zhang","doi":"10.1177/03000605251324492","DOIUrl":"10.1177/03000605251324492","url":null,"abstract":"Myoepithelioma-like hyalinizing epithelioid tumors (MHETs) are distinct soft tissue neoplasms characterized by their unique histological presentation, including myoepithelioma-like hyalinization and an epithelioid-cell pattern. A defining molecular characteristic of these tumors is the presence of a novel OGT::FOXO gene fusion. Their distinct morphology makes diagnosis challenging because they can be mistaken for other soft tissue tumors. We report the case of a 71-year-old man who was admitted to our hospital with a 1-year history of a palpable mass on the left palm. Physical examination revealed a well-defined, mobile mass on the lateral aspect of the left palm, measuring 2.0 × 3.0 cm, with moderate consistency. The tumor was surgically excised, and postoperative pathology based on immunohistochemical staining and tissue morphology confirmed the diagnosis of MHET. The tumor cells exhibited diffuse positivity for CD34 and focal positivity for EMA. At the 3-month follow-up post-surgery, there was no evidence of recurrence or distant metastasis. MHETs are typically observed as superficial, well-circumscribed masses without the histological features of malignancy. Given the distinct tissue morphology and the recent identification of this tumor type, clinicians and pathologists must be aware of these features to facilitate accurate diagnosis and inform treatment strategies.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251324492"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sudden airway obstruction during emergence from general anesthesia in a post-radiation nasopharyngeal carcinoma patient with lower cranial nerve injury: A case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-21 DOI: 10.1177/03000605251325655

Wei-Chao Zhu, Li Hu, Shuai Kang

引用次数: 0

Retraction: Nephroprotective effect of losartan in IgA model rat.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-04-01 DOI: 10.1177/03000605251330127

引用次数: 0

Ultrasound characteristics and correlation with estimated glomerular filtration rate in patients with chronic kidney disease: A facility-based cross-sectional study.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-27 DOI: 10.1177/03000605251327484

Fekadu H Getaneh, Bezamariam F Kassa, Lidet G Amha, Ferehiwot B Getaneh

{"title":"Ultrasound characteristics and correlation with estimated glomerular filtration rate in patients with chronic kidney disease: A facility-based cross-sectional study.","authors":"Fekadu H Getaneh, Bezamariam F Kassa, Lidet G Amha, Ferehiwot B Getaneh","doi":"10.1177/03000605251327484","DOIUrl":"https://doi.org/10.1177/03000605251327484","url":null,"abstract":"ObjectiveTo evaluate grayscale sonographic characteristics and their correlation with the estimated glomerular filtration rate.Methodology: This cross-sectional study included 103 patients with stage III and above chronic kidney disease. Correlation between ultrasonography measurements and estimated glomerular filtration rate was performed. Differences in the mean estimated glomerular filtration rate were evaluated using one-way analysis of variance.ResultsThe mean (± SD) estimated glomerular filtration rate was 34.47 ± 15.81 mL/min/1.73 m2 (range: 9.6-45.9 mL/min/1.73 m2). The mean (± SD) average renal length was 8.97 ± 1.42 cm. The mean parenchymal and cortical thicknesses were 1.36 ± 0.45 and 0.85 ± 0.27 cm, respectively. There was a significant correlation between the estimated glomerular filtration rate and the average renal length, relative renal length, and parenchymal thickness (r = 0.26, p = 0.009; r = 0.25, p = 0.01; and r = 0.25, p = 0.01, respectively). A statistically significant negative correlation was observed between renal echogenicity and estimated glomerular filtration rate (p < 0.001).ConclusionA correlation was noted between the degree of renal function loss and sonographic findings. This indicates that ultrasound can be used in combination with other modalities for the diagnosis, assessment, and monitoring of chronic kidney disease.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251327484"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abemaciclib-associated kidney injuries: A retrospective analysis of the United States Food and Drug Administration adverse events reporting system. Abemaciclib相关肾损伤：对美国食品和药物管理局不良事件报告系统的回顾性分析。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-21 DOI: 10.1177/03000605251325961

Xiangchun Xu, Xuzheng Guo, Jinhui Chen, Yuhua Pan, Jing Li, Jing Chen, Weihua Lai, Lu Lin

{"title":"Abemaciclib-associated kidney injuries: A retrospective analysis of the United States Food and Drug Administration adverse events reporting system.","authors":"Xiangchun Xu, Xuzheng Guo, Jinhui Chen, Yuhua Pan, Jing Li, Jing Chen, Weihua Lai, Lu Lin","doi":"10.1177/03000605251325961","DOIUrl":"https://doi.org/10.1177/03000605251325961","url":null,"abstract":"BackgroundAbemaciclib, an oral kinase inhibitor, is used to treat hormone receptor-positive and HER2-negative breast cancer patients. However, there has been a decrease in studies reporting adverse reactions to abemaciclib-related kidney injuries. Thus, this study was aimed at assessing its safety profile using a large-scale pharmacovigilance database.MethodsAbemaciclib-related adverse drug reaction reports from the Food and Drug Administration Adverse Event Reporting System were obtained and scrutinized, and adverse drug reactions were selected using reporting odds ratio, the proportional reporting ratio methods, empirical Bayes geometric mean and UK Medicines and Healthcare products Regulatory Agency methods.ResultsWe selected 10,757 matched reports associated with abemaciclib, among which we found eight adverse reactions about kidney injuries correlated with abeamciclib, such as increased blood creatinine, renal disorder, decreased glomerular filtration rate, increased blood urea, hydronephrosis, abnormal renal function test, increased creatinine renal clearance and increased cystatin C. A demographic analysis of reported cases of abemaciclib-associated renal injury revealed that the majority were female, aged ≥46 years and had taken the drug ≥30 days.ConclusionThis study highlights the characteristics of adverse reactions with abemaciclib and those associated with renal damage, which are crucial for safety studies on the clinical use of this drug.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325961"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report: False-positive B-type natriuretic peptide results with the cyclic amplified fluorescence immunoassay. 病例报告：环形扩增荧光免疫分析法的 B 型钠尿肽假阳性结果。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-22 DOI: 10.1177/03000605251325942

Qian Yin, Fei Wang, Chen Zhang, Yi-Bin Pan

{"title":"Case report: False-positive B-type natriuretic peptide results with the cyclic amplified fluorescence immunoassay.","authors":"Qian Yin, Fei Wang, Chen Zhang, Yi-Bin Pan","doi":"10.1177/03000605251325942","DOIUrl":"10.1177/03000605251325942","url":null,"abstract":"B-type natriuretic peptide, which was initially isolated from porcine brain tissue, has been used in the clinic as an important indicator for the diagnosis, risk stratification, and prognosis of heart failure. In recent years, many commercial immunoassays to assess B-type natriuretic peptide have been reported to undergo interference due to various factors. At present, the commonly used assays to assess B-type natriuretic peptide are enzyme-linked immunosorbent assay and direct chemiluminescence, which are based on a \"sandwich structure\" formed by dual antibodies; both assays have been reported to undergo interference. We report the case of a patient whose B-type natriuretic peptide results, which were detected using a cyclic amplified fluorescence immunoassay, were false-positive. The patient had a low-risk pulmonary embolism without right heart failure; however, her B-type natriuretic peptide results were surprisingly high. Further study confirmed that the abnormal B-type natriuretic peptide result was caused by the interference of the human anti-mouse antibodies. Therefore, when encountering B-type natriuretic peptide results that are not consistent with the clinical situation, the possibility of interference in the assay should be considered.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325942"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed tomography-based radiomics modeling to predict patient overall survival in cervical cancer with intensity-modulated radiotherapy combined with concurrent chemotherapy. 基于计算机断层扫描的放射组学模型预测宫颈癌患者在接受调强放疗和同期化疗后的总生存期。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-22 DOI: 10.1177/03000605251325996

Lihong Xiao, Youhua Wang, Xiangxiang Shi, Haowen Pang, Yunfei Li

{"title":"Computed tomography-based radiomics modeling to predict patient overall survival in cervical cancer with intensity-modulated radiotherapy combined with concurrent chemotherapy.","authors":"Lihong Xiao, Youhua Wang, Xiangxiang Shi, Haowen Pang, Yunfei Li","doi":"10.1177/03000605251325996","DOIUrl":"10.1177/03000605251325996","url":null,"abstract":"ObjectiveThe objective of this study was to develop a predictive model combining radiomic characteristics and clinical features to forecast overall survival in cervical cancer patients treated with intensity-modulated radiotherapy and concurrent chemotherapy.MethodsIn this retrospective observational study, 159 patients were divided into a training group (n = 95) and a validation group (n = 64). Radiomic characteristics were extracted from contrast-enhanced computed tomography scans. The least absolute shrinkage and selection operator regression analysis was used to filter the extracted radiomic characteristics and reduce the dimensionality of the data. A radiomic score was calculated from the selected features, and multivariate Cox regression models were established to analyze overall survival. A nomogram combining radiomic score and clinical features was developed, and its reliability was assessed using the area under the receiver operating characteristic curve.ResultsFour radiomic characteristics and two clinical features were extracted for overall survival analysis. A nomogram combining these factors was developed and validated, showing good performance with a high C-index. Patients were categorized as low-risk or high-risk for overall survival based on a cut-off value.ConclusionsOur model combining computed tomography-extracted radiomic characteristics and clinical features shows good potential for evaluating overall survival in cervical cancer patients treated with intensity-modulated radiotherapy and concurrent chemotherapy.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325996"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0