Journal of International Medical Research最新文献_第2页

Relationship between maternal iron status and the risk of congenital heart defects: A case-control study. 母体铁含量与先天性心脏缺陷风险的关系：一项病例对照研究

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-09 DOI: 10.1177/03000605251356004

Raghdah Qaddour, Ranwa Alsayed

{"title":"Relationship between maternal iron status and the risk of congenital heart defects: A case-control study.","authors":"Raghdah Qaddour, Ranwa Alsayed","doi":"10.1177/03000605251356004","DOIUrl":"10.1177/03000605251356004","url":null,"abstract":"ObjectiveThe cause of most congenital heart defect cases remains unknown. A previous study showed a link between maternal iron deficiency and congenital heart defects in mice; however, this association is not yet clear in humans. This study aimed to explore the potential relationship between maternal iron status and congenital heart defects in infants.MethodsWe conducted a case-control study, including 70 mothers whose infants had congenital heart defects and their infants (case group) and 30 mothers whose infants did not have any congenital heart defects and their infants (control group). We interviewed eligible mothers and collected peripheral blood samples to analyze iron-related biomarkers. We used binomial logistic regression to estimate the odds ratio (95% confidence intervals) for the association of maternal iron status with congenital heart defects.ResultsSerum ferritin, serum iron, and transferrin saturation levels were lower, while total iron binding capacity was higher among mothers of the case group than among those of the control group (p < 0.05). Additionally, mothers in the case group were at higher risk of having iron deficiency (odds ratio = 2.91, 95% confidence interval: 1.143-7.418) than those in the control group.ConclusionsMaternal iron status was lower among mothers of the case group than among those of the control group. Furthermore, mothers in the case group had a greater likelihood of experiencing iron deficiency than those in the control group.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251356004"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryptococcal infection of the femur misdiagnosed as a primary bone tumor: A case report and literature review. 股骨隐球菌感染误诊为原发性骨肿瘤1例并文献复习。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-25 DOI: 10.1177/03000605251359432

Bin Liu, Yiyun Ni, Haifeng Zeng, Min Tang, Junnan Jiang

{"title":"Cryptococcal infection of the femur misdiagnosed as a primary bone tumor: A case report and literature review.","authors":"Bin Liu, Yiyun Ni, Haifeng Zeng, Min Tang, Junnan Jiang","doi":"10.1177/03000605251359432","DOIUrl":"10.1177/03000605251359432","url":null,"abstract":"Cryptococcal infections are uncommon, and musculoskeletal involvement of the femur is extremely rare, often resulting in diagnostic challenges. A woman in her early 70s presented with a 20-day history of progressive left thigh pain that was aggravated by limb movement. Initial evaluation at a local hospital suspected a primary bone tumor based on radiographic findings of an osteolytic lesion in the midshaft of the left femur. Laboratory tests revealed elevated C-reactive protein level, erythrocyte sedimentation rate, and ferritin levels, but no malignant tumor markers were detected. Radiological assessment, including magnetic resonance imaging and whole-body scintigraphy, raised the suspicion of a primary bone tumor, with differential diagnoses including eosinophilic granuloma or Brodie's abscess. An ultrasound-guided biopsy revealed spindle cell proliferation with multinucleated giant cells, with no evidence of malignancy. A multidisciplinary consultation attributed the finding to either an infectious etiology or a possible false-negative result of B-mode ultrasound-guided biopsy. The patient subsequently underwent debridement and biopsy of the affected bone in the left thigh. Although microbial cultures were negative, immunohistochemical analysis showed features consistent with cryptococcal infection. Special staining demonstrated the characteristic thick capsules of Cryptococcus spp., confirming the diagnosis of a cryptococcal granuloma in the left femur. Early diagnosis and timely treatment are important to effectively manage cryptococcal bone infections.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359432"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple occurrences of membranous nephropathy complicated with anti-glomerular basement membrane antibody and anti-neutrophil cytoplasm antibody double-negative crescentic formation since the COVID-19 pandemic: A case series. 新冠肺炎大流行以来多发膜性肾病合并抗肾小球基底膜抗体和抗中性粒细胞细胞质抗体双阴性月牙形的病例分析

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-23 DOI: 10.1177/03000605251357467

Shuang Yuan, Chao Li, ZhiBo Guo, Guang Yang, LiHong Zhang, Tao Wang

{"title":"Multiple occurrences of membranous nephropathy complicated with anti-glomerular basement membrane antibody and anti-neutrophil cytoplasm antibody double-negative crescentic formation since the COVID-19 pandemic: A case series.","authors":"Shuang Yuan, Chao Li, ZhiBo Guo, Guang Yang, LiHong Zhang, Tao Wang","doi":"10.1177/03000605251357467","DOIUrl":"10.1177/03000605251357467","url":null,"abstract":"There has been an unusual increase in the incidence of anti-glomerular basement membrane disease, anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis, and double-positive cases since the coronavirus disease 2019 (COVID-19) pandemic. Rare cases have been consistently reported, including anti-glomerular basement membrane antibody and ANCA double-positive crescentic glomerulonephritis after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as well as coexistent membranous nephropathy and proteinase 3 ANCA-associated crescentic glomerulonephritis following vaccination. We described both anti-phospholipase A2 receptor (PLA2R) antibody-positive and -negative membranous nephropathy superimposed on anti-glomerular basement membrane disease. Upon and beyond these findings, we herein reported three cases of biopsy-confirmed membranous nephropathy concurrent with anti-glomerular basement membrane antibody and ANCA double-negative crescentic formation, which manifested as acute kidney injury clinically. In one case, repeated renal biopsies confirmed de novo occurrence of crescents in the setting of PLA2R-associated primary membranous nephropathy immediately after SARS-CoV-2 infection. Subsequent use of anti-CD20 agents led to substantial recovery of renal function in two patients. Our report indicated that an indirect process resulting from downstream implications of this viral infection may be responsible for a plethora of unusual entities in glomerular diseases since the COVID-19 pandemic. As such, emerging insights may help decipher the complexity of these increasingly recognized yet equally detrimental clinicopathologic combinations, particularly in the post-COVID-19 era.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251357467"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recombinant growth hormone for children with systemic lupus erythematosus and linear growth delay: A report of two cases and literature review. 重组生长激素治疗系统性红斑狼疮并发线性生长迟缓儿童2例报告并文献复习。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-30 DOI: 10.1177/03000605251359426

Fujuan Liu, Xiaoying Yuan, Yanjun Yang, Yanan Han, Lanlan Ge, Jingxiao Guo, Ling Liu, Chunzhen Li, Dongfeng Zhang

{"title":"Recombinant growth hormone for children with systemic lupus erythematosus and linear growth delay: A report of two cases and literature review.","authors":"Fujuan Liu, Xiaoying Yuan, Yanjun Yang, Yanan Han, Lanlan Ge, Jingxiao Guo, Ling Liu, Chunzhen Li, Dongfeng Zhang","doi":"10.1177/03000605251359426","DOIUrl":"https://doi.org/10.1177/03000605251359426","url":null,"abstract":"Linear growth delay is common in children with systemic lupus erythematosus. There have been scattered reports of using recombinant human growth hormone in these children, but safety remains a major concern. We herein report two cases of successful treatment with recombinant human growth hormone in children with systemic lupus erythematosus: a 15-year 10-month-old boy (case 1; disease duration: 4 years; height: 149 cm (<3rd percentile, Z-score <-3); and bone age: 11 years) and a 12-year 8-month-old boy (case 2; disease duration: 5 years; height: 149.5 cm (10th percentile, Z-score = -1); and bone age: 12 years). Both children had been in complete remission for 6 and 30 months, respectively. Insulin-like growth factor-1, insulin-like growth factor-binding protein 3, adrenocorticotropic hormone, and cortisol levels were normal in both cases. Recombinant human growth hormone treatment lasted for 17 and 16 months, respectively. The height increase was 22 and 19 cm during the treatment period, respectively. Systemic lupus erythematosus remained in complete remission on maintenance therapy with hydroxychloroquine/tacrolimus and hydroxychloroquine/mycophenolate mofetil, respectively. Literature search identified two cases. At the time of recombinant human growth hormone treatment initiation, case 1 had proteinuria and elevated serum creatinine level, and case 2 had positive anti-double-stranded DNA antibodies. Relapse occurred immediately after recombinant human growth hormone treatment in both cases. In conclusion, recombinant human growth hormone treatment may be considered for linear growth delay in children with systemic lupus erythematosus if disease activity is sufficiently controlled.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359426"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive transcranial magnetic stimulation for late-life depression: A systematic review and meta-analysis of randomized controlled trials. 重复经颅磁刺激治疗老年抑郁症：随机对照试验的系统回顾和荟萃分析。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-28 DOI: 10.1177/03000605251359613

Panpan Yang, Lin Li, Rui Zhang, Hailong Li

{"title":"Repetitive transcranial magnetic stimulation for late-life depression: A systematic review and meta-analysis of randomized controlled trials.","authors":"Panpan Yang, Lin Li, Rui Zhang, Hailong Li","doi":"10.1177/03000605251359613","DOIUrl":"10.1177/03000605251359613","url":null,"abstract":"ObjectiveRepetitive transcranial magnetic stimulation is considered a potential treatment of choice for late-life depression, but its efficacy remains unclear. Therefore, we conducted a systematic review and meta-analysis to investigate the efficacy of repetitive transcranial magnetic stimulation.MethodsWe systematically searched PubMed, Embase, Cochrane Library, and PsycINFO databases. Meta-analyses were performed to examine the improvement in depression measured by the Hamilton Depression Rating Scale score, response rate, and remission rate after repetitive transcranial magnetic stimulation treatment.ResultsA total of 10 trials were included. The pooled results revealed an improvement in the Hamilton Depression Rating Scale score (standardized mean difference: 0.51; 95% confidence interval: 0.33, 0.68), response rate (odds ratio: 2.62; 95% confidence interval: 1.37, 5.01), and remission rate (odds ratio: 6.88; 95% confidence interval: 2.93, 16.14). The pooled results of trials using repetitive transcranial magnetic stimulation with an intensity of ≥100% resting motor threshold revealed an improvement in the Hamilton Depression Rating Scale score (standardized mean difference: 3; 95% confidence interval: 1.87, 4.12) and response rate (odds ratio: 2.56; 95% confidence interval: 1.58, 4.13). No differences were observed in the pooled results of trials using repetitive transcranial magnetic stimulation with an intensity of <100% resting motor threshold.ConclusionRepetitive transcranial magnetic stimulation is effective in the treatment of late-life depression, especially with an intensity of ≥100% resting motor threshold. Future studies with larger sample sizes and long-term outcomes are still needed to provide more robust evidence.INPLASY registration number: INPLASY202550075.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359613"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary retention caused by mirtazapine in a patient with geriatric depression: A case report. 米氮平引起老年抑郁症患者尿潴留1例。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1177/03000605251353195

Lee-Hou Tsai, Jeng-Wen Lin, Maw-Sheng Lee, Yennun Huang

{"title":"Urinary retention caused by mirtazapine in a patient with geriatric depression: A case report.","authors":"Lee-Hou Tsai, Jeng-Wen Lin, Maw-Sheng Lee, Yennun Huang","doi":"10.1177/03000605251353195","DOIUrl":"10.1177/03000605251353195","url":null,"abstract":"Depression, dementia, and delirium comprise the \"3 Ds\" of mental illness diagnoses in the older population. Depression is a common condition. Older adults may passively deal with depression, may not adhere to their prescribed drug schedules, and may be prone to unexpected side effects. A 70-year-old man with depression was brought by his family to the clinic with a 2-month history of depressed mood and poor drug compliance. After being diagnosed with depression, mirtazapine treatment was started. The following day, his family members suspected that the use of psychiatric drugs had caused acute urinary retention; hence, they brought him back to the emergency department. The emergency physician diagnosed the patient with benign prostatic hyperplasia and admitted him to the psychiatric ward after urinary catheterization. This case illustrates the effects of mirtazapine on urinary function in older individuals, particularly those with a history of benign prostatic hyperplasia. Although low-dose short-acting benzodiazepines and non-benzodiazepine hypnotics (Z-drugs) have been used to reduce the anticholinergic cognitive burden, mirtazapine inevitably induces acute urinary retention in older males with benign prostatic hyperplasia. Thus, the possibility of acute urinary retention caused by mirtazapine, particularly in patients with benign prostatic hyperplasia, cannot be ignored.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251353195"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appropriateness and safety of using the intranasal route for sedation during pediatric computed tomography: A randomized controlled trial at Korle-Bu teaching hospital. 小儿计算机断层扫描时鼻内镇静的适宜性和安全性：Korle-Bu教学医院的一项随机对照试验

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-18 DOI: 10.1177/03000605251357455

Beauty Naa Yarley Annan, Ebenezer Owusu Darkwa, Audrey Anno, Naa Matekour Vanderpuye, Lorraine Baffour-Awuah, Grace-Imelda Obeng Adjei, Owusu-Sekyere Danso, Raymond Essuman, George Aryee, Robert Djagbletey

{"title":"Appropriateness and safety of using the intranasal route for sedation during pediatric computed tomography: A randomized controlled trial at Korle-Bu teaching hospital.","authors":"Beauty Naa Yarley Annan, Ebenezer Owusu Darkwa, Audrey Anno, Naa Matekour Vanderpuye, Lorraine Baffour-Awuah, Grace-Imelda Obeng Adjei, Owusu-Sekyere Danso, Raymond Essuman, George Aryee, Robert Djagbletey","doi":"10.1177/03000605251357455","DOIUrl":"10.1177/03000605251357455","url":null,"abstract":"ObjectiveThis study aimed to determine the effectiveness and safety of using intranasal ketamine, midazolam, or their combination for sedation during pediatric computed tomography.MethodIn this randomized, double-blind study, 60 children aged ≤2.5 years who were scheduled to undergo computed tomography were allocated into the following three groups: Group K (ketamine 10 mg/kg), Group M (midazolam 0.2 mg/kg), and Group C (ketamine 7.5 mg/kg + midazolam 0.1 mg/kg). In all cases, the drugs were administered intranasally. Sedation parameters were assessed.ResultOf the 60 randomized participants, 10 were excluded due to failed sedation. Data from 16 (Group M), 14 (Group K), and 20 (Group C) participants were analyzed. The mean sedation scores were similar: Groups K (2.86 ± 0.38), M (2.63 ± 0.74), and C (2.70 ± 0.68) (p = 0.579). Time to adequate sedation was shortest in Group C (22 ± 9 min; p = 0.022). Recovery was fastest in Group M (63 ± 25 min; p = 0.007). Discharge times differed significantly (p = 0.036) among the groups, with Group M exhibiting a discharge time of 92 ± 29 min. Group C had superior parental separation scores compared with the other groups (p = 0.035).ConclusionIntranasal administration of ketamine, midazolam, or their combination is safe and effective for inducing sedation during computed tomography in pediatric patients with minimal side effects.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251357455"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Empagliflozin attenuates ventricular fibrillation postmyocardial infarction associated with reduced transforming growth factor-β1/Smad3 signaling and miR-181a expression. 恩格列净减轻与转化生长因子-β1/Smad3信号和miR-181a表达减少相关的心肌梗死后心室颤动。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-14 DOI: 10.1177/03000605251353040

Jingsong Shen, Min Huang, Zixu Ye, Yuling Jing, Ziyang Yuan, Zeming Xiang, Miao Ding, Tao Li, Qiang Ye

{"title":"Empagliflozin attenuates ventricular fibrillation postmyocardial infarction associated with reduced transforming growth factor-β1/Smad3 signaling and miR-181a expression.","authors":"Jingsong Shen, Min Huang, Zixu Ye, Yuling Jing, Ziyang Yuan, Zeming Xiang, Miao Ding, Tao Li, Qiang Ye","doi":"10.1177/03000605251353040","DOIUrl":"10.1177/03000605251353040","url":null,"abstract":"ObjectiveTo determine whether empagliflozin reduces ventricular fibrillation and myocardial fibrosis after myocardial infarction via the transforming growth factor-β1/Smad3/miR-181a pathway.MethodsMale nondiabetic Sprague-Dawley rats (n = 16) were randomized into sham, myocardial infarction, low-dose empagliflozin (10 mg/kg/day), and high-dose empagliflozin (30 mg/kg/day) groups. Myocardial infarction was induced via coronary artery ligation. After 4 weeks, ventricular fibrillation thresholds were assessed via electrical stimulation. Cardiac function (echocardiography), fibrosis (Masson's trichrome staining), and molecular markers (transforming growth factor-β1, Smad3, miR-181a; assessed via western blotting/quantitative polymerase chain reaction) were analyzed.ResultsEmpagliflozin-treated groups showed reduced left ventricular dilation (left ventricular internal diameters at end-diastole: 8.2 ± 0.3 vs. 9.1 ± 0.4 mm in myocardial infarction; left ventricular internal diameters at end-systole: 5.1 ± 0.2 vs. 6.0 ± 0.3 mm) and improved ejection fraction (45% vs. 38% in myocardial infarction). Ventricular fibrillation thresholds increased significantly with empagliflozin administration (p < 0.05). Myocardial fibrosis (collagen volume fraction: 12% vs. 25% in myocardial infarction) and transforming growth factor-β1/Smad3/miR-181a expression were downregulated in empagliflozin groups (p < 0.01). No dose-dependent differences were observed between the groups.ConclusionsEmpagliflozin attenuates postmyocardial infarction ventricular arrhythmias and fibrosis associated with the suppression of transforming growth factor-β1/Smad3 signaling and miR-181a expression, enhancing cardiac function. These findings highlight its therapeutic potential in postinfarct remodeling.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251353040"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the outcomes of patients with non-male factor infertility and poor ovarian response undergoing in vitro fertilization and intracytoplasmic sperm injection. 非男性因素不孕和卵巢反应差患者行体外受精和卵胞浆内单精子注射的结局比较。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-25 DOI: 10.1177/03000605251359470

Haiwei Quan, Qi Yan, Jingyi Han, Rulin Dai

{"title":"Comparison of the outcomes of patients with non-male factor infertility and poor ovarian response undergoing in vitro fertilization and intracytoplasmic sperm injection.","authors":"Haiwei Quan, Qi Yan, Jingyi Han, Rulin Dai","doi":"10.1177/03000605251359470","DOIUrl":"10.1177/03000605251359470","url":null,"abstract":"ObjectivesTo investigate whether intracytoplasmic sperm injection can achieve better embryonic and clinical outcomes compared with in vitro fertilization in women with non-male factor infertility and poor ovarian response.MethodsThis retrospective cohort study analyzed data from a single academically affiliated fertility clinic. The participants included couples with non-male factor infertility and poor ovarian response (normal male spermatozoa) who underwent oocyte retrieval with an oocyte yield of ≤4 between January 2016 and December 2022.ResultsA total of 766 oocyte retrieval cycles were included, with 318 cycles in the in vitro fertilization group and 448 in the intracytoplasmic sperm injection group. The in vitro fertilization group showed a higher fertilization rate (89.31% vs. 83.06%, p = 0.0002), while the intracytoplasmic sperm injection group had higher two-pronuclear fertilization rates and higher quality of embryos (76.90% vs. 67.44%, p < 0.001 and 54.86% vs. 43.94%, p < 0.001, respectively). However, no significant differences were observed in the clinical pregnancy rates, ongoing pregnancy rates, live birth rates, miscarriage rates, embryo implantation rates, and cumulative live birth rates between the two groups. In addition, multivariate logistic regression analysis, adjusted for potential confounding factors, showed no significant differences in the clinical pregnancy and live birth rates between the two groups.ConclusionIn women with non-male factor infertility and poor ovarian response, intracytoplasmic sperm injection provides no significant improvements in embryonic or clinical outcomes compared with in vitro fertilization.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251359470"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fever of unknown origin and pharyngitis as harbingers of natural killer/T-cell lymphoma: A case report highlighting diagnostic challenges. 不明原因的发热和咽炎作为自然杀手/ t细胞淋巴瘤的先兆：一个病例报告强调诊断挑战。

IF 1.5 4区医学

Journal of International Medical Research Pub Date : 2025-07-01 Epub Date: 2025-07-23 DOI: 10.1177/03000605251357430

Lantian Pang, Yingli Zhao, Xiaocui Wu, Hui Zhou

{"title":"Fever of unknown origin and pharyngitis as harbingers of natural killer/T-cell lymphoma: A case report highlighting diagnostic challenges.","authors":"Lantian Pang, Yingli Zhao, Xiaocui Wu, Hui Zhou","doi":"10.1177/03000605251357430","DOIUrl":"10.1177/03000605251357430","url":null,"abstract":"Fever of unknown origin is one of the most challenging clinical symptoms, with complex etiologies including infections, malignancies, and rheumatic immune diseases. Lymphoma is a common malignant tumor associated with fever of unknown origin, and its early diagnosis is often difficult because routine laboratory tests and imaging manifestations may fail to provide a definitive diagnosis. Here, we report the case of a patient with natural killer/T-cell lymphoma who primarily presented with long-term fever and pharyngodynia. The patient sought medical care at several hospitals and underwent multiple laryngoscopies and a biopsy of the tongue base. After >3 months from the time of initial presentation, the diagnosis was ultimately confirmed through the second biopsy of the tongue base. The case highlights the diagnostic challenges of lymphoma with atypical symptoms in the context of fever of unknown origin and underscores the role of infectious disease physicians in diagnosing noninfectious diseases related to fever of unknown origin.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 7","pages":"3000605251357430"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0