Journal of International Medical Research最新文献

{"title":"Mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 deficiency with severe hyperglycemia in a child: A rare case report.","authors":"Chang Dong, Tiantian Lu, Yazhou Jiang, Zihao Yan, Suyue Zhu","doi":"10.1177/03000605251375537","DOIUrl":"https://doi.org/10.1177/03000605251375537","url":null,"abstract":"<p><p>Mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 (HMGCS2) deficiency is an exceptionally rare autosomal recessive metabolic disorder that impairs ketogenesis. It is typically characterized by hypoketotic hypoglycemia during periods of fasting or metabolic stress. Notably, severe hyperglycemia as an initial presenting symptom has not been previously reported. We report the case of a 6-month-old girl who suddenly developed coma after 1 day of fasting due to repeated vomiting during pneumonia. At presentation, she had hyperglycemia (25.8 mmol/L), ketonuria (1+), glucosuria (3+), metabolic acidosis (pH 6.90), elevated serum alanine transaminase and aspartate aminotransferase levels, increased blood ammonia levels, and liver enlargement on ultrasound. However, fasting insulin, glucagon, and glycated hemoglobin levels were all within the normal range. Whole-exome sequencing identified compound heterozygous mutations in the HMGCS2 gene-c.1175C>T (p.S392L) inherited from the father and c.719A>T (p.A240V) inherited from the mother-thereby confirming the diagnosis of HMGCS2 deficiency. This case highlights severe hyperglycemia as an atypical clinical feature of HMGCS2 deficiency. Increased awareness of such rare manifestations may assist in improving early diagnosis and treatment of this condition.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375537"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study.","authors":"Tao Zhang, Ya Zhou, Long-Fei Luo, Deng-Jun Ji, Liang Wang, Jun Xie, An-Ning Zhu, Jun-Tao Yan, Zhen Yan, Li Gong, Wu-Quan Sun","doi":"10.1177/03000605251367610","DOIUrl":"10.1177/03000605251367610","url":null,"abstract":"<p><p>ObjectiveSarcopenia poses a significant global public health burden, underscoring the urgency of identifying reliable risk markers for early detection and intervention. This study aimed to elucidate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia as well as explore how various covariates modify this relationship.MethodsA cross-sectional analysis was performed using data from 9040 individuals who participated in the National Health and Nutrition Examination Survey 2011-2018, of whom 721 were diagnosed with sarcopenia. Multivariable logistic regression models were employed to estimate the odds ratios and 95% confidence intervals for the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Restricted cubic spline regression analysis was utilized to assess the nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk. Subgroup analysis was performed to identify the relationship between different subgroups of neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Considering the conflict between the lower age threshold and the diagnostic criteria for sarcopenia, we conducted sensitivity analysis among participants aged ≥40 years.ResultsMultivariable logistic regression analysis revealed that the neutrophil-to-high-density lipoprotein cholesterol ratio was positively associated with sarcopenia risk (odds ratio = 1.16, 95% confidence interval: 1.11-1.22, <i>P </i><<i> </i>0.0001). Restricted cubic spline regression analysis demonstrated a nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (nonlinear <i>P </i><<i> </i>0.05). Subgroup analyses indicated that sex, race, and hyperlipidemia significantly modified the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (<i>P</i> for interaction <0.05).ConclusionsAn elevated neutrophil-to-high-density lipoprotein cholesterol ratio is associated with a high risk of sarcopenia, indicating that the ratio can effectively assess the risk of sarcopenia and may contribute to early diagnosis and preventive intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251367610"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessory cavitated uterine malformation in a perimenopausal woman: Case report and literature review.","authors":"Yuan Zhang, Hanxue Lv, Congjie Lin, Hua Liu","doi":"10.1177/03000605251372459","DOIUrl":"10.1177/03000605251372459","url":null,"abstract":"<p><p>Accessory cavitated uterine malformation is a rare congenital anomaly of Müllerian duct development that typically affects younger women of reproductive age. The most common symptoms include chronic cyclic pelvic pain and severe dysmenorrhea, although diagnosis is frequently delayed owing to its rarity, multiple differential diagnoses, and low patient awareness. This report describes the case of a perimenopausal woman with accessory cavitated uterine malformation. The patient exhibited a palpable mass in the right lower abdomen without notable chronic pelvic pain or dysmenorrhea. It was initially misdiagnosed as an adnexal cyst in the right region based on ultrasound imaging, and laparoscopic exploration revealed a mass in the uterine corpus, leading to a revised diagnosis of accessory cavitated uterine malformation, which was confirmed through intraoperative findings and histopathological examination. The postoperative outcomes were favorable. This case underscores the diagnostic challenges of accessory cavitated uterine malformation, given the limited research on its pathogenesis and the absence of distinctive diagnostic markers. Imaging and histopathology are essential for an accurate diagnosis. Surgical intervention, especially laparoscopy, remains the preferred treatment, with excision typically resulting in a favorable postoperative prognosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372459"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between occupational dust exposure and asthma prevalence in a nationally representative US population.","authors":"Yi Dai, Yonghuai Li","doi":"10.1177/03000605251371280","DOIUrl":"https://doi.org/10.1177/03000605251371280","url":null,"abstract":"<p><p>ObjectiveThis study sought to examine the relationship between exposure to different types of workplace dust (mineral dust, organic dust, exhaust fumes, and other fumes) and the prevalence of asthma in a nationally representative sample of the population in the United States.MethodsUsing data from the National Health and Nutrition Examination Survey 2007-2012, we analyzed data of 16,841 participants after exclusions based on specific criteria. Logistic regression models were used to evaluate the association between dust exposure and asthma prevalence after adjusting for demographic and health-related covariates.ResultsOur findings indicate that exposure to various types of dust is positively associated with the prevalence of asthma. This association remained significant after adjusting for age, sex, race, and other covariates. Notably, subgroup analysis revealed that females are more susceptible to asthma from dust exposure than males. In addition, individuals with higher body mass index and older age are more likely to have asthma due to dust inhalation.ConclusionThis study underscores the need for targeted occupational health interventions and policies, especially for high-risk groups such as females, those with higher body weight, and older individuals. Further longitudinal studies are recommended to establish causal relationships.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251371280"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective case-control study: Analysis of the analgesic effect of acetaminophen-mannitol injection after endoscopic lumbar discectomy.","authors":"Jie-Bin Huang, Yin-Feng Guo, Cheng-Zhao Li, Wei-Xiong Chen, Bai-Yong Zhu, Yu Lei, Wei-Dong Jiao, Li-Bin Zheng, Hou-Jun Xue","doi":"10.1177/03000605251372518","DOIUrl":"10.1177/03000605251372518","url":null,"abstract":"<p><p>ObjectiveTo investigate the analgesic effects of acetaminophen-mannitol injections after endoscopic lumbar discectomy.MethodsThis is a prospective case-control study involving 60 patients who were randomly selected from those who underwent endoscopic lumbar discectomy for lumbar disc herniation or lumbar spinal stenosis at Sanshui District People's Hospital of Foshan between April and September 2024. Two groups were formed by randomly assigning patients, with each group containing 30 individuals. The observation group underwent treatment with acetaminophen-mannitol for pain relief, whereas the control group was administered oral etoricoxib and intravenous mannitol. A comparison was made between the analgesic effects of the two groups.ResultsCompared with the control group, the observation group showed significantly lower visual analog scale scores on the first, third, and seventh days after operation (<i>P</i> < 0.05). The observation group had a similar time to start walking and length of hospital stay as the control group. The total incidence rate of adverse reactions was zero.ConclusionAcetaminophen-mannitol injection has a good analgesic effect after endoscopic lumbar discectomy, which is beneficial for accelerating the postoperative recovery of patients.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372518"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative delirium after short-acting spinal anesthesia and general anesthesia after shared decision-making.","authors":"Valesca Kipping, Timo B Kerlin, Friedrich Borchers, Margret F Külken, Marilena Schmid, Christopher S Ahrend, Janine Wiebach, Sophie K Piper, Klaus D Wernecke, Anika Müller, Claudia D Spies","doi":"10.1177/03000605251363408","DOIUrl":"https://doi.org/10.1177/03000605251363408","url":null,"abstract":"<p><p>ObjectivePrevious studies have shown that the postoperative delirium rate does not differ between anesthetic techniques in randomized controlled trials. Subjective concerns such as anxiety and pain are often not adequately addressed in randomized controlled trials and reported to be associated with postoperative delirium. Shared decision-making is reported to have an impact on anxiety and pain. Therefore, the aim of this study was to evaluate the effect of shared decision-making while making a choice between spinal and general anesthesia on postoperative delirium incidence.MethodsThis prospective, observational, two-armed cohort study included 192 patients who underwent lower extremity, lower abdominal, pelvic, or perineal short-time surgery that lasted <90 min. The three-talk shared decision-making model was used to make the choice for the type of anesthesia. Depending on the shared decision-making process, either spinal anesthesia with short-acting local anesthetics (prilocaine hydrochloride or chloroprocaine hydrochloride) or general anesthesia was performed according to a standardized protocol including intraoperative electroencephalogram monitoring. Patients' anxiety and pain levels were measured before and after the surgery using validated scales.ResultsBased on their shared decision-making choice of anesthesia, 97 patients were allocated to the spinal anesthesia group and 95 to the general anesthesia group. Postoperative delirium occurred less frequently after spinal anesthesia (2.1%) than after general anesthesia (16.8%; p < 0.001). No postoperative delirium was observed in patients who received only spinal anesthesia, as chosen using the shared decision-making model (spinal anesthesia: 0%, general anesthesia 16.8%; p < 0.001). Anxiety and pain levels did not differ between the two groups.ConclusionsThe incidence of postoperative delirium was lower in patients who were administered spinal anesthesia than in those who were administered general anesthesia after using a shared decision-making approach. Integrating patients' perspectives and treatment preferences might change postoperative outcomes and should be taken into consideration in future trials.<b>Trial registration:</b> clinicaltrials.gov: NCT03715244https://clinicaltrials.gov/study/NCT03715244?intr=NCT03715244&rank=1.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251363408"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of retroperitoneal leiomyosarcoma originating from the right ovarian vein and invading the right renal vein and inferior vena cava.","authors":"Chengbin Lu, Leyu Zhang, Benmo Xu, Tianyu Li, Die Fan, Changyang Li, Yuanlong Shi, Xin Li, Bin Zhao","doi":"10.1177/03000605251364059","DOIUrl":"10.1177/03000605251364059","url":null,"abstract":"<p><p>A woman in her early 50s was admitted to our hospital with a right retroperitoneal tumor that had been detected >1 year ago. Imaging studies revealed a mass in the right middle and lower retroperitoneum, which involved the upper portion of the right fallopian tube and caused dilated hydronephrosis of the right renal pelvis and calyces. Initial diagnosis suggested benign intraventricular smooth muscle neoplasia. She underwent surgical resection of the right retroperitoneal tumor, along with thrombectomy of the right renal vein and inferior vena cava, as well as artificial revascularization of the right renal vein. Postoperative pathology confirmed retroperitoneal smooth muscle sarcoma. She received postoperative chemotherapy with ifosfamide and doxorubicin as well as anticoagulation therapy with rivaroxaban. One year later, follow-up imaging revealed multiple nodules in the right middle and lower abdomen, a blurred nodule in the tail of the pancreas, and a dilated pancreatic duct in the distal pancreas, raising suspicion of metastasis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251364059"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircDock6 drives metabolic dysfunction-associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation.","authors":"Hongpeng Lu, Xiaoyun Ding, Peifei Li","doi":"10.1177/03000605251362984","DOIUrl":"10.1177/03000605251362984","url":null,"abstract":"<p><p>ObjectiveCircular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction-associated steatotic liver disease. This study sought to examine the functional role and molecular mechanism of circDock6 in metabolic dysfunction-associated steatotic liver disease.MethodsQuantitative reverse transcription polymerase chain reaction was performed to determine <i>circDock6</i> expression patterns in liver tissues from high-fat diet- and standard diet-fed mice in vivo. Triglyceride detection, western blot analysis, and oil red O staining were performed to evaluate the regulatory effect of circDock6 on metabolic dysfunction-associated steatotic liver disease in vitro.Results<i>CircDock6</i> was found to be markedly overexpressed in high-fat diet liver tissues compared with that in standard diet tissues. Moreover, knockdown of <i>circDock6</i> expression lowered triglyceride content and lipid droplet formation. Mechanistically, circDock6 acted as a molecular sponge for mmu-let-7g-5p, which regulated insulin-like growth factor 1 receptor expression and contributed to the progression of metabolic dysfunction-associated steatotic liver disease. <i>CircDock6</i> knockdown suppressed metabolic dysfunction-associated steatotic liver disease progression by modulating insulin-like growth factor 1 receptor via mmu-let-7g-5p targeting.ConclusionOur study identified circDock6 as a novel regulator of metabolic dysfunction-associated steatotic liver disease pathogenesis through the mmu-let-7g-5p/insulin-like growth factor 1 receptor axis, indicating its potential as a therapeutic target for metabolic dysfunction-associated steatotic liver disease intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251362984"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of myositis-specific autoantibodies in the diagnosis of idiopathic inflammatory myopathy and tumor risk prediction.","authors":"Lili Shi, Rong Min, Yanyan Wu, Jiahui Liu, Xia Liu, Peichang Wang","doi":"10.1177/03000605251362969","DOIUrl":"10.1177/03000605251362969","url":null,"abstract":"<p><p>ObjectiveTo investigate the value of myositis-specific autoantibodies in the diagnosis of idiopathic inflammatory myopathy and tumor risk prediction in patients with clinically suspected idiopathic inflammatory myopathy.MethodsThis retrospective study analyzed the myositis-specific autoantibodies and clinical characteristics of 357 patients with clinically suspected idiopathic inflammatory myopathy. Statistical analyses were conducted to assess the associations between myositis-specific autoantibodies and clinical symptoms.ResultsAmong the 357 patients with suspected idiopathic inflammatory myopathy, the co-occurrence rate of anti-synthetase and anti-Ro52 was 52.63%. Univariate analysis demonstrated significantly higher diagnostic rates of idiopathic inflammatory myopathy in patients positive for anti-synthetase and anti-Ro52 than in those who were seronegative. Patients who tested positive for anti-signal recognition particle exhibited distinct serological profiles and diagnostic outcomes compared with those who tested negative. Significant associations were observed between myositis-specific autoantibodies and tumor biomarkers. Multivariate logistic regression analysis identified serum creatinine and anti-synthetase antibody positivity as independent diagnostic predictors of idiopathic inflammatory myopathy.DiscussionAnti-synthetase antibodies were independently associated with idiopathic inflammatory myopathy. Co-positivity for anti-synthetase and anti-Ro52 was closely related to the diagnosis of idiopathic inflammatory myopathy. Myositis antibodies were significantly correlated with tumor biomarkers, highlighting their potential utility in early cancer screening. Elevated serum creatinine was also independently associated with idiopathic inflammatory myopathy, exhibiting diagnostic significance.ConclusionMyositis-specific autoantibodies have potential clinical value for early tumor screening and the diagnosis of idiopathic inflammatory myopathy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251362969"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring optimal serum selenium range for heart failure prevention: A U-shaped association and mediation by hepatic steatosis in US adults.","authors":"Han Li, Wenhu Liu, Jingjie Xiong, Xuehua Wang, Qian Xu, Ni Xiong, Yanling Huang, Yan Wang, Jing Hu, Zhaohui Wang","doi":"10.1177/03000605251370320","DOIUrl":"https://doi.org/10.1177/03000605251370320","url":null,"abstract":"<p><p>ObjectiveThe relationship between serum selenium levels and heart failure risk remains unclear. This study aimed to investigate the potential nonlinear association between serum selenium level and heart failure risk and explore whether hepatic steatosis and dyslipidemia mediate this relationship.MethodsData from 6969 adults in the National Health and Nutrition Examination Survey 2017-2020 cohort were analyzed. Logistic regression, restricted cubic spline, and random forest models were used to assess associations between serum selenium level and heart failure risk. Mediation analysis was used to evaluate the indirect effects of hepatic steatosis and lipid parameters. Mendelian randomization was used to infer causality.ResultsA U-shaped association was identified between serum selenium level and heart failure risk (<i>P</i> for nonlinearity = 0.003), with the lowest risk observed at 150-160 µg/L. Both low and high selenium levels were associated with increased heart failure risk. Hepatic steatosis and lipid markers partially mediated this association. Mendelian randomization analysis suggested a potential causal effect of genetically predicted serum selenium level on heart failure risk.ConclusionThese findings highlight a nonlinear association between selenium exposure and heart failure and suggest possible metabolic pathways underlying this association. However, further research is needed before any clinical recommendations can be made.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251370320"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}