Journal of International Medical Research最新文献

{"title":"Optimal trajectory for the anterior occipital condyle screw.","authors":"Zhenqi Lou, Jieyang Zhu, Kanling Jiang, Sanqiang Xia, Sihui Chen, Jinyu Zhu, Yi Jiang","doi":"10.1177/03000605251325677","DOIUrl":"10.1177/03000605251325677","url":null,"abstract":"<p><p>ObjectiveThis study aimed to assess the practicality and optimal approach for inserting an anterior occipital condyle screw, as well as to measure the screw placement characteristics.MethodsA total of 80 normal head and cervical spine computed tomography scans (40 males/40 females) were used to construct three-dimensional models. The average age of the participants was 45.18 ± 8.86 years (ranging from 25 to 65 years). Three potential entry points for the anterior occipital condyle screw were identified. A simulated screw with a radius of 1.75 mm was created to replicate the screw trajectory and adjusted to establish the maximum and minimum cranial limits for each entry point. The feasibility of screw fixation was assessed, identifying the optimal entry point and analyzing relevant screw placement measurements.ResultsThe success rates for screw placement were 95.6%, 94.4%, and 88.1% for the middle, lateral, and medial entry points, respectively. The success rate for the medial entry point was notably lower than that for the middle and lateral points. No statistically significant differences were found in the measured parameters between the left and right sides. The medial entry point exhibited the highest abduction angulation (35.72° ± 2.01°) for screw placement, followed by the middle (25.96° ± 1.86°) and lateral (15.14° ± 1.82°) points. The middle and lateral entry points displayed a considerably wider safe range of cranial angulation and screw placement length than the medial entry point. All three entry points achieved success rates exceeding 90% when the cranial angulation ranged from 2° to 6°.ConclusionThe anterior occipital condyle screw presents a workable choice for anterior craniovertebral fixation. The middle entry point is identified as the optimal approach for placing 3.5-mm diameter screws.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325677"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myeloid leukemia with <i>DEK::NUP214</i> fusion resembling acute promyelocytic leukemia, initially presenting as sweet syndrome: A case report and literature review.","authors":"Huan Liu, Guo-Xia Liu, Feng-Hai Liu, Shu-Guo Wang","doi":"10.1177/03000605251327476","DOIUrl":"10.1177/03000605251327476","url":null,"abstract":"<p><p>Some subtypes of acute myeloid leukemia share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia but lack a promyelocytic leukemia-retinoic acid receptor alpha fusion gene. Herein, we present a case of acute myeloid leukemia with morphological and clinical features resembling those of acute promyelocytic leukemia, carrying the rare DEK::NUP214 fusion gene and presenting with sweet syndrome as the initial manifestation. In our case, the patient with acute myeloid leukemia carrying <i>DEK::NUP214</i> fusion exhibited highly active bone marrow proliferation, with increased basophil and promyelocyte counts. To the best of our knowledge, this is the first reported case of acute promyelocytic leukemia-like acute myeloid leukemia carrying <i>DEK::NUP214</i> fusion.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251327476"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aslanger pattern: A case report.","authors":"Zhixiong Zhong","doi":"10.1177/03000605251327380","DOIUrl":"10.1177/03000605251327380","url":null,"abstract":"<p><p>Patients with Aslanger pattern are characterized by a more conspicuous incidence of multivessel coronary artery disease, a more remarkable probability of chronic complete occlusion, and a more alarming rate of hospitalization. Owing to the insufficient understanding of electrocardiographic characteristics of Aslanger pattern by a multitude of clinicians, it is commonly undetected or misdiagnosed as reversible inferior myocardial ischemia, which gives rise to prolonged reperfusion time. The electrocardiographic characteristics of Aslanger pattern cannot be stereotyped. Aslanger pattern typically indicates a higher likelihood of multivessel disease and a prevalent occurrence of acute coronary occlusion, with electrocardiographic changes being complex in such cases of multivessel disease. Aslanger pattern must be managed in accordance with ST elevation myocardial infarction. Both emergency interventional therapy and coronary artery bypass grafting are appropriate.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251327380"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mandibular third molar impactions and distal carious lesions on the adjacent second molars: A cross-sectional study.","authors":"Naji Z Arandi, Ahmad Jarrar","doi":"10.1177/03000605251324489","DOIUrl":"10.1177/03000605251324489","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the prevalence and patterns of impacted mandibular third molars (MTMs) and their association with distal caries in adjacent mandibular second molars (MSMs).MethodsA total of 2000 randomly selected orthopantomograms (OPGs) were analyzed. MTM impaction patterns were classified using Winter's and Pell-Gregory systems, and distal caries on MSMs were assessed. Statistical analyses included chi-square tests and multivariate logistic regression to evaluate associations between impaction characteristics and caries prevalence.ResultsOf the 1594 eligible OPGs, 37% exhibited MTM impactions. Among the 828 impacted MTMs identified, 19.56% were associated with carious lesions on the distal surface of adjacent MSMs. Statistical analysis revealed that mesioangular impactions significantly increased the likelihood of distal caries in MSMs. In contrast, Pell-Gregory Classes II-C and III-C were associated with reduced odds of caries. Age emerged as a strong predictor, whereas gender and other Winter's classification categories did not significantly influence caries occurrence.ConclusionImpacted MTMs are associated with an increased risk of caries on the distal surface of MSMs. Impaction patterns and patient age influenced the prevalence of caries. Prophylactic removal of impacted MTMs in high-risk cases may help reduce the risk of caries development in MSMs.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251324489"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of the efficacy and safety of immunomodulators in the treatment of severe COVID-19.","authors":"Xuegui Ju, Jiayao Li, Haonan Huang, Yidan Qing, Bhushan Sandeep","doi":"10.1177/03000605251317462","DOIUrl":"10.1177/03000605251317462","url":null,"abstract":"<p><p>ObjectiveTo evaluate the efficacy and adverse events of immunomodulators in the treatment of severe coronavirus disease 2019 (COVID-19).MethodsA literature search for the meta-analysis was performed using PubMed, The Cochrane Library, Embase, Wanfang Data, CNKI, and Web of Science to identify randomized controlled trials assessing the outcomes of patients treated with corticosteroids alone and/or interleukin-6 receptor antagonists for COVID-19. The risk of bias was assessed using the Cochrane method. The protocol was registered with PROSPERO (registry number: CRD42022356904).ResultsCompared with patients receiving standard of care, patients treated with corticosteroids alone had an increased risk of 14-day in-hospital death, whereas those treated with interleukin-6 receptor antagonists alone or in combination with corticosteroids had a lower risk of 14-day in-hospital death. Corticosteroid therapy alone was associated with increased risk of several adverse events, including intensive care unit admission and non-invasive ventilation, whereas interleukin-6 receptor antagonists alone or in combination with corticosteroids were not linked to adverse effects.ConclusionsThe findings supported the safety and efficacy of interleukin-6 receptor antagonists, either alone or together with corticosteroids, in patients with severe COVID-19; evidence supporting the efficacy and safety of corticosteroids monotherapy is lacking.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251317462"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the study of Wellens syndrome.","authors":"Yiwen Zhang, Youlu Shen","doi":"10.1177/03000605251324480","DOIUrl":"10.1177/03000605251324480","url":null,"abstract":"<p><p>This article outlines a comprehensive analysis of the progress in the study of Wellens syndrome, which starts from a large body of relevant literature and systematically elaborates on the in-depth discussion, including the definition of the Wellens syndrome and the relationship between myocardial ischemia and coronary artery lesions. In terms of clinical manifestations, the characteristic electrocardiographic changes and related symptoms are described in detail. In terms of diagnostic methods, it ranges from the identification of electrocardiographic features to the combined use of myocardial marker testing and imaging. In conclusion, research on Wellens syndrome has further improved an understanding of its etiopathological mechanisms. This review aimed to clarify the nuances of Wellens syndrome and its impact on cardiovascular practice, raising awareness of at-risk populations and improving patient outcomes. It also provides a comprehensive and in-depth reference for the recognition, diagnosis, and treatment of Wellens syndrome to help clinicians fully understand and effectively diagnose and treat it.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251324480"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing hepatic porphyria: Insights from a quaternary care hospital in Bogotá, Colombia (2013-2023).","authors":"María C Martínez-Ávila, Eugenio Matijasevic-Arcila, Stefania Pantoja-Chica, Alieth L Acosta-Cardozo","doi":"10.1177/03000605251325183","DOIUrl":"10.1177/03000605251325183","url":null,"abstract":"<p><p>IntroductionAcute hepatic porphyrias are rare, life-threatening genetic disorders that impair heme biosynthesis, often presenting with nonspecific symptoms that lead to misdiagnosis. This diagnostic challenge and low clinical recognition can delay targeted treatment, increasing morbidity and mortality. Although there have been advances in understanding porphyrias' biochemical pathways, improved diagnostic approaches are still needed, especially in acute care. This study examined diagnostic and clinical patterns of acute hepatic porphyria at a quaternary care hospital in Bogotá, Colombia, to support earlier detection and management.Materials and MethodsThis descriptive, observational, retrospective study reviewed patients diagnosed with acute hepatic porphyria at the Internal Medicine service of a Bogotá hospital from 2013 to 2023. Patients with confirmed diagnoses recorded in the hospital database were included. Data collected covered demographic characteristics, clinical presentation, diagnostic markers, and treatment. Key outcome measures were time to diagnosis, recurrence frequency, and hospitalization duration.ResultsTen patients were included, 80% of whom were female, with a median age of 32 years. Diagnosis was confirmed by urine porphobilinogen tests. All patients reported abdominal pain during attacks; 90% had tachycardia and paresis/weakness of extremities. Attack durations ranged from 4 to 11 days, with 90% treated with hemin. Median hospital stay was 18 days. Drug use and infections were common precipitants, and 40% of female patients had premenstrual-associated attacks.ConclusionsThis study provides a clinical profile of acute hepatic porphyria in a Colombian hospital, highlighting neurovisceral symptoms and female predominance. Findings suggest the need for early diagnostic protocols to prevent treatment delays, although larger studies are required to confirm these findings across different settings.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325183"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic cystic echinococcosis (type II): A case report.","authors":"Zhiru Liang, Weihong Chen, Binbin Zhang, Lina Chen, Jing Wang, Jianjia Xiao, Geer An","doi":"10.1177/03000605251325164","DOIUrl":"10.1177/03000605251325164","url":null,"abstract":"<p><p>This article presents a case report of a rare instance of hepatic cystic echinococcosis (Type II). The patient is a young female who has resided in the Inner Mongolia region of China for an extended period and has a clear history of contact with dogs and sheep. She presented with recurrent upper abdominal pain accompanied by jaundice of skin and sclera for 2 months. Through comprehensive clinical history inquiry, physical examination, and imaging studies such as ultrasound and computed tomography, the diagnosis of hepatic cystic echinococcosis (Type II) was confirmed. The patient underwent a capsular excision, and the postoperative prognosis was good with no recurrence or implantation during short-term follow-up. This case report details the patient's clinical symptoms, signs, diagnostic process, and key points for differential diagnosis, emphasizing the crucial role of imaging studies in the diagnosis of hepatic cystic echinococcosis. Additionally, the treatment plan and postoperative follow-up for this case are discussed, aiming to provide a reference for clinical diagnosis and treatment of hepatic cystic echinococcosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251325164"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective observational study of risk factors for postoperative meningitis following resection of meningioma.","authors":"Yong Gu, Yuekang Zhang, Mengfei Zeng, Yangyun Han, Xiaodong Long","doi":"10.1177/03000605251327527","DOIUrl":"10.1177/03000605251327527","url":null,"abstract":"<p><p>ObjectiveThis retrospective observational study aimed to explore the risk factors for postoperative meningitis following resection of meningioma.MethodsA total of 937 patients older than 18 years who underwent meningioma resection at the Department of Neurosurgery of three grade-A general hospitals in Sichuan Province between January 2021 and June 2024 were included. Basic patient information and perioperative variables were evaluated as risk factors for meningitis. Univariate and multivariate analyses were performed to identify the risk factors for postoperative meningitis.ResultsOverall, 47 (5.0%) of the 937 patients were infected with postoperative meningitis. Univariate analysis revealed that albumin level (<3.5 mg/dL; p = 0.017), preoperative hospitalization (median: 4 days; interquartile range: 2-6 days; p = 0.034), tumor location (skull base; p < 0.001), surgery duration (>3 h; p < 0.001), and bleeding volume during operation (≥400 mL; p < 0.001) were significantly associated with postoperative meningitis following resection of meningioma. The average postoperative hospital stay in the postoperative meningitis group was 14 days, whereas it was 6 days in the nonpostoperative meningitis group (p < 0.001). Furthermore, multivariate analysis showed that tumor location (skull base; p = 0.004; odds ratio = 2.914; 95% confidence interval: 1.395-6.091), surgery duration (>3 h; p = 0.006; odds ratio = 3.024; 95% confidence interval: 1.370-6.674), and bleeding volume during operation (p = 0.034; odds ratio = 2.057; 95% confidence interval: 1.056-4.006) were independent risk factors for postoperative meningitis following resection of meningioma.ConclusionTumor location (skull base), longer surgery duration (>3 h), and higher bleeding volume during operation (≥400 mL) were independent risk factors for postoperative meningitis following resection of meningioma. Moreover, postoperative meningitis was associated with a prolonged hospital stay. These findings can help identify patients with meningioma in need of special intervention to prevent postoperative meningitis and can help surgeons preoperatively identify the risk of postoperative meningitis for meningioma.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 3","pages":"3000605251327527"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory cardiogenic shock in hypertrophic cardiomyopathy complicated by apical ballooning: A case report.","authors":"Matej Strycek, Rostislav Polasek, Pavol Tomasov, Jiri Karasek","doi":"10.1177/03000605251315345","DOIUrl":"10.1177/03000605251315345","url":null,"abstract":"<p><p>Hypertrophic cardiomyopathy can be accompanied by dynamic obstruction in the left ventricular outflow tract and acute apical ballooning, which are among the very rare causes of cardiogenic shock. This condition requires a specific treatment approach that in many ways differs from the treatment of other causes of cardiogenic shock. We present a case and our treatment strategy (including extracorporeal life support) for refractory cardiogenic shock in a patient with previously undiagnosed hypertrophic cardiomyopathy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315345"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}