Journal of International Medical Research最新文献

{"title":"Assessing the relationship between anthropometric indices and visceral adipose tissue: A cross-sectional study in a Qatari population.","authors":"Rawan Ajeen, Karam I Turk-Adawi, Alice S Ammerman, John A Batsis, Shu Wen Ng, Linda S Adair","doi":"10.1177/03000605251371603","DOIUrl":"10.1177/03000605251371603","url":null,"abstract":"<p><p>ObjectiveTo evaluate how body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio reflect visceral adipose tissue as measured by dual-energy X-ray absorptiometry and how these associations differ by sex and age in a Qatari adult population.MethodsIn this cross-sectional study of 5897 Qatari adults aged 18-88 years from the Qatar BioBank, we assessed the correlation between anthropometric indices and dual-energy X-ray absorptiometry-derived visceral adipose tissue percentage. Analyses included sex-stratified Spearman's correlations and linear regression models adjusted for age. Model performance was assessed using standardized beta coefficients, <i>R</i>², adjusted <i>R</i>², Akaike Information Criterion, and Bayesian Information Criterion.ResultsAmong females, waist circumference and waist-to-height ratio had the strongest correlations with visceral adipose tissue (<i>r</i> = 0.70), followed by waist-to-hip ratio (<i>r</i> = 0.68), whereas body mass index showed a moderate correlation with visceral adipose tissue (<i>r</i> = 0.54). Among males, waist-to-hip ratio showed the highest correlation with visceral adipose tissue (<i>r</i> = 0.71). Regression analyses confirmed waist-to-hip ratio as the strongest predictor in males and waist circumference as the strongest in females. Interaction models showed that associations between central adiposity indices and visceral adipose tissue strengthened with age.ConclusionAnthropometric indices reflecting central adiposity, waist-to-hip ratio, waist circumference, and waist-to-height ratio outperformed body mass index in predicting visceral adipose tissue in a sex- and age-specific manner. These findings may support the clinical utility of incorporating waist-based measures for visceral adipose tissue risk assessment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251371603"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve implantation in a patient with isolated aortic regurgitation using JenaValve.","authors":"Lina Xia, Wei Peng, Li Chen, Li Li","doi":"10.1177/03000605251369848","DOIUrl":"10.1177/03000605251369848","url":null,"abstract":"<p><p>This case report details the successful use of JenaValve for transcatheter aortic valve implantation in a male patient in his early 50s with severe aortic regurgitation. The patient had multiple comorbidities, including chronic kidney disease and heart failure, increasing the risk of surgical intervention. JenaValve, a second-generation device with unique positioning and anchoring mechanisms, was deployed successfully, resulting in immediate improvements in cardiac function without significant regurgitation or paravalvular leakage. This case highlights the potential of transcatheter aortic valve implantation as a viable alternative to surgical aortic valve replacement in patients with severe aortic regurgitation, emphasizing the importance of technological advancements and a multidisciplinary approach in managing complex cardiovascular cases. Long-term follow-up is essential to assess the durability of the implanted valve and the patient's overall prognosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251369848"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent single-organ cutaneous small-vessel vasculitis with streptococcal infection in a pediatric patient: A case report.","authors":"Min Yang, Xiuying Chen, Zhihua Zhang, Lijuan Hu, Yannan Guo, Songhui Zhai","doi":"10.1177/03000605251368334","DOIUrl":"10.1177/03000605251368334","url":null,"abstract":"<p><p>Single-organ cutaneous small-vessel vasculitis is a specific type of vasculitis. Its recurrence rate is approximately 10%, and it is a serious health issue that can lead to increased healthcare costs. There have been no reports of successful treatment of recurrent necrotizing single-organ cutaneous small-vessel vasculitis in children. We report the case of an 11-year-old Chinese girl who presented with recurrently elevated anti-streptococcal O titers and worsening cutaneous necrosis of the lower extremities. She was diagnosed with streptococcal infection-related recurrent severe single-organ cutaneous small-vessel vasculitis and was successfully treated using a \"cocktail\" therapy, including antibiotics, plasma exchange, and immunosuppressants. She was followed up for 4 years with no recurrence. In conclusion, recurrent necrotizing single-organ cutaneous small-vessel vasculitis in children can be successfully treated with a \"cocktail\" therapy containing plasma exchange.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251368334"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple injections of indocyanine green for improving the outcomes of lymphatic-venous anastomosis reconstruction of lymphatic return under microscopy: A case report.","authors":"Haoxiang Zhu, Huipeng Zhu, Yuanjie Bao","doi":"10.1177/03000605251375258","DOIUrl":"10.1177/03000605251375258","url":null,"abstract":"<p><p>This study explores effective treatment methods for chronic secondary lymphedema after radical cervical cancer surgery combined with pelvic lymphadenectomy. In cases where conservative treatment was ineffective, we investigated whether multiple injections of indocyanine green can effectively improve the outcomes of lymphatic-venous anastomosis under microscopy. Preoperative lymphatic imaging was used to localize functional vessels, guiding distal left lower limb lymphatic reconstruction. Intraoperatively, supermicroscopy (40×) and real-time indocyanine green imaging enabled eight end-to-end anastomoses between 0.5- and 1.3-mm lymphatic capillaries and subcutaneous veins. Each anastomosis took ≤30 min, with intraoperative lymphangiography confirming patency. Immediate postoperative lymphatic diversion to veins was observed. By day 3, reconstructed pathway efficiency reached 83% of the healthy side, with visual analog scale pain scores decreasing from 5 to 2. At 3-6 months, mid-thigh and calf circumferences reduced progressively; ultrasound confirmed edema resolution and complete cessation of exudation. High-precision multipoint supermicrosurgical anastomosis achieved anatomical and functional reconstruction of chronic secondary lymphedema, overcoming traditional size and functional limitations. Innovations included multipoint design to prevent reobstruction and dynamic imaging-guided precision. This case establishes a radical treatment strategy for chronic secondary lymphedema.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375258"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessory cavitated uterine malformation in a perimenopausal woman: Case report and literature review.","authors":"Yuan Zhang, Hanxue Lv, Congjie Lin, Hua Liu","doi":"10.1177/03000605251372459","DOIUrl":"10.1177/03000605251372459","url":null,"abstract":"<p><p>Accessory cavitated uterine malformation is a rare congenital anomaly of Müllerian duct development that typically affects younger women of reproductive age. The most common symptoms include chronic cyclic pelvic pain and severe dysmenorrhea, although diagnosis is frequently delayed owing to its rarity, multiple differential diagnoses, and low patient awareness. This report describes the case of a perimenopausal woman with accessory cavitated uterine malformation. The patient exhibited a palpable mass in the right lower abdomen without notable chronic pelvic pain or dysmenorrhea. It was initially misdiagnosed as an adnexal cyst in the right region based on ultrasound imaging, and laparoscopic exploration revealed a mass in the uterine corpus, leading to a revised diagnosis of accessory cavitated uterine malformation, which was confirmed through intraoperative findings and histopathological examination. The postoperative outcomes were favorable. This case underscores the diagnostic challenges of accessory cavitated uterine malformation, given the limited research on its pathogenesis and the absence of distinctive diagnostic markers. Imaging and histopathology are essential for an accurate diagnosis. Surgical intervention, especially laparoscopy, remains the preferred treatment, with excision typically resulting in a favorable postoperative prognosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372459"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between occupational dust exposure and asthma prevalence in a nationally representative US population.","authors":"Yi Dai, Yonghuai Li","doi":"10.1177/03000605251371280","DOIUrl":"https://doi.org/10.1177/03000605251371280","url":null,"abstract":"<p><p>ObjectiveThis study sought to examine the relationship between exposure to different types of workplace dust (mineral dust, organic dust, exhaust fumes, and other fumes) and the prevalence of asthma in a nationally representative sample of the population in the United States.MethodsUsing data from the National Health and Nutrition Examination Survey 2007-2012, we analyzed data of 16,841 participants after exclusions based on specific criteria. Logistic regression models were used to evaluate the association between dust exposure and asthma prevalence after adjusting for demographic and health-related covariates.ResultsOur findings indicate that exposure to various types of dust is positively associated with the prevalence of asthma. This association remained significant after adjusting for age, sex, race, and other covariates. Notably, subgroup analysis revealed that females are more susceptible to asthma from dust exposure than males. In addition, individuals with higher body mass index and older age are more likely to have asthma due to dust inhalation.ConclusionThis study underscores the need for targeted occupational health interventions and policies, especially for high-risk groups such as females, those with higher body weight, and older individuals. Further longitudinal studies are recommended to establish causal relationships.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251371280"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective case-control study: Analysis of the analgesic effect of acetaminophen-mannitol injection after endoscopic lumbar discectomy.","authors":"Jie-Bin Huang, Yin-Feng Guo, Cheng-Zhao Li, Wei-Xiong Chen, Bai-Yong Zhu, Yu Lei, Wei-Dong Jiao, Li-Bin Zheng, Hou-Jun Xue","doi":"10.1177/03000605251372518","DOIUrl":"10.1177/03000605251372518","url":null,"abstract":"<p><p>ObjectiveTo investigate the analgesic effects of acetaminophen-mannitol injections after endoscopic lumbar discectomy.MethodsThis is a prospective case-control study involving 60 patients who were randomly selected from those who underwent endoscopic lumbar discectomy for lumbar disc herniation or lumbar spinal stenosis at Sanshui District People's Hospital of Foshan between April and September 2024. Two groups were formed by randomly assigning patients, with each group containing 30 individuals. The observation group underwent treatment with acetaminophen-mannitol for pain relief, whereas the control group was administered oral etoricoxib and intravenous mannitol. A comparison was made between the analgesic effects of the two groups.ResultsCompared with the control group, the observation group showed significantly lower visual analog scale scores on the first, third, and seventh days after operation (<i>P</i> < 0.05). The observation group had a similar time to start walking and length of hospital stay as the control group. The total incidence rate of adverse reactions was zero.ConclusionAcetaminophen-mannitol injection has a good analgesic effect after endoscopic lumbar discectomy, which is beneficial for accelerating the postoperative recovery of patients.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372518"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative delirium after short-acting spinal anesthesia and general anesthesia after shared decision-making.","authors":"Valesca Kipping, Timo B Kerlin, Friedrich Borchers, Margret F Külken, Marilena Schmid, Christopher S Ahrend, Janine Wiebach, Sophie K Piper, Klaus D Wernecke, Anika Müller, Claudia D Spies","doi":"10.1177/03000605251363408","DOIUrl":"https://doi.org/10.1177/03000605251363408","url":null,"abstract":"<p><p>ObjectivePrevious studies have shown that the postoperative delirium rate does not differ between anesthetic techniques in randomized controlled trials. Subjective concerns such as anxiety and pain are often not adequately addressed in randomized controlled trials and reported to be associated with postoperative delirium. Shared decision-making is reported to have an impact on anxiety and pain. Therefore, the aim of this study was to evaluate the effect of shared decision-making while making a choice between spinal and general anesthesia on postoperative delirium incidence.MethodsThis prospective, observational, two-armed cohort study included 192 patients who underwent lower extremity, lower abdominal, pelvic, or perineal short-time surgery that lasted <90 min. The three-talk shared decision-making model was used to make the choice for the type of anesthesia. Depending on the shared decision-making process, either spinal anesthesia with short-acting local anesthetics (prilocaine hydrochloride or chloroprocaine hydrochloride) or general anesthesia was performed according to a standardized protocol including intraoperative electroencephalogram monitoring. Patients' anxiety and pain levels were measured before and after the surgery using validated scales.ResultsBased on their shared decision-making choice of anesthesia, 97 patients were allocated to the spinal anesthesia group and 95 to the general anesthesia group. Postoperative delirium occurred less frequently after spinal anesthesia (2.1%) than after general anesthesia (16.8%; p < 0.001). No postoperative delirium was observed in patients who received only spinal anesthesia, as chosen using the shared decision-making model (spinal anesthesia: 0%, general anesthesia 16.8%; p < 0.001). Anxiety and pain levels did not differ between the two groups.ConclusionsThe incidence of postoperative delirium was lower in patients who were administered spinal anesthesia than in those who were administered general anesthesia after using a shared decision-making approach. Integrating patients' perspectives and treatment preferences might change postoperative outcomes and should be taken into consideration in future trials.<b>Trial registration:</b> clinicaltrials.gov: NCT03715244https://clinicaltrials.gov/study/NCT03715244?intr=NCT03715244&rank=1.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251363408"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of retroperitoneal leiomyosarcoma originating from the right ovarian vein and invading the right renal vein and inferior vena cava.","authors":"Chengbin Lu, Leyu Zhang, Benmo Xu, Tianyu Li, Die Fan, Changyang Li, Yuanlong Shi, Xin Li, Bin Zhao","doi":"10.1177/03000605251364059","DOIUrl":"10.1177/03000605251364059","url":null,"abstract":"<p><p>A woman in her early 50s was admitted to our hospital with a right retroperitoneal tumor that had been detected >1 year ago. Imaging studies revealed a mass in the right middle and lower retroperitoneum, which involved the upper portion of the right fallopian tube and caused dilated hydronephrosis of the right renal pelvis and calyces. Initial diagnosis suggested benign intraventricular smooth muscle neoplasia. She underwent surgical resection of the right retroperitoneal tumor, along with thrombectomy of the right renal vein and inferior vena cava, as well as artificial revascularization of the right renal vein. Postoperative pathology confirmed retroperitoneal smooth muscle sarcoma. She received postoperative chemotherapy with ifosfamide and doxorubicin as well as anticoagulation therapy with rivaroxaban. One year later, follow-up imaging revealed multiple nodules in the right middle and lower abdomen, a blurred nodule in the tail of the pancreas, and a dilated pancreatic duct in the distal pancreas, raising suspicion of metastasis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251364059"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircDock6 drives metabolic dysfunction-associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation.","authors":"Hongpeng Lu, Xiaoyun Ding, Peifei Li","doi":"10.1177/03000605251362984","DOIUrl":"10.1177/03000605251362984","url":null,"abstract":"<p><p>ObjectiveCircular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction-associated steatotic liver disease. This study sought to examine the functional role and molecular mechanism of circDock6 in metabolic dysfunction-associated steatotic liver disease.MethodsQuantitative reverse transcription polymerase chain reaction was performed to determine <i>circDock6</i> expression patterns in liver tissues from high-fat diet- and standard diet-fed mice in vivo. Triglyceride detection, western blot analysis, and oil red O staining were performed to evaluate the regulatory effect of circDock6 on metabolic dysfunction-associated steatotic liver disease in vitro.Results<i>CircDock6</i> was found to be markedly overexpressed in high-fat diet liver tissues compared with that in standard diet tissues. Moreover, knockdown of <i>circDock6</i> expression lowered triglyceride content and lipid droplet formation. Mechanistically, circDock6 acted as a molecular sponge for mmu-let-7g-5p, which regulated insulin-like growth factor 1 receptor expression and contributed to the progression of metabolic dysfunction-associated steatotic liver disease. <i>CircDock6</i> knockdown suppressed metabolic dysfunction-associated steatotic liver disease progression by modulating insulin-like growth factor 1 receptor via mmu-let-7g-5p targeting.ConclusionOur study identified circDock6 as a novel regulator of metabolic dysfunction-associated steatotic liver disease pathogenesis through the mmu-let-7g-5p/insulin-like growth factor 1 receptor axis, indicating its potential as a therapeutic target for metabolic dysfunction-associated steatotic liver disease intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251362984"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}