Journal of International Medical Research最新文献

{"title":"Advances in drug-coated balloons for the treatment of coronary artery de novo large-vessel lesions.","authors":"Lizhi Lin, Xiaorong Yin, Meng Chen, Lu Cui, Cheng Shen, Yong Cao","doi":"10.1177/03000605251342671","DOIUrl":"10.1177/03000605251342671","url":null,"abstract":"<p><p>The incidence and mortality of coronary heart disease are increasing annually, and the disease is now one of the leading causes of death in China. Percutaneous coronary intervention has become the preferred approach for treating coronary artery disease. The use of a drug-coated balloon is a new treatment strategy for coronary artery disease that has been shown to be safe and effective in intravascular restenosis, bifurcation disease, and small-vessel disease, and this approach has been extended to other indications, such as large-vessel coronary artery disease. However, some experts believe that the intima muscularis fibrosa of large vessels is thick. After dilation of large vessels with drug-coated balloons, elastic contraction may occur. Additionally, the use of drug-coated balloons cannot prevent the occurrence of vessel dissection; therefore, their use for treating large-vessel coronary disease remains controversial. This review has aimed to discuss the findings of clinical trials demonstrating the efficacy and safety of drug-coated balloons for the treatment of coronary artery de novo large-vessel lesions.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251342671"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of portal venous gas caused by the use of a nasojejunal nutrition tube.","authors":"Youshun Liu, Yong Li, Chunping Zhu, Haifeng Liu, Ji Huang","doi":"10.1177/03000605251340529","DOIUrl":"10.1177/03000605251340529","url":null,"abstract":"<p><p>We reported a case of portal vein pneumatosis caused by a nasojejunal nutrition tube that was successfully treated conservatively. This patient was discharged after 1 week of treatment with imipenem/cilastatin sodium for anti-infection, gastrointestinal decompression, fluid replacement, and pain relief, and the patient's abdominal pain was significantly relieved. The main pathogenesis of hepatic portal venous gas is as follows: (a) increased pressure in the digestive tract leading to gas entering the portal vein circulation through the intestinal wall and finally into the liver; (b) destruction of the intestinal mucosa causing the gas formed by intestinal bacteria to enter the portal vein system; and (c) diffusion of gas produced by bacteria in intraperitoneal abscesses or portal vein and mesentery, causing pyelitis. The successful treatment of this patient highlights that addressing physical factors, providing gastrointestinal decompression, and administering anti-infection therapy can aid in the management of such cases. Bacterial culture of gastric juice and drug sensitivity testing can guide effective anti-infection treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251340529"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color duplex ultrasound-guided percutaneous transluminal angioplasty for hemodialysis-associated venous hypertension syndrome: A retrospective study of safety and efficacy.","authors":"Jianbin Zhang, Yongjun Hu, Runhong Tang, Jie Liu, Yi Li, Hongmin Zhao, Lili Hong, Yan Chen, Zhen Li","doi":"10.1177/03000605251347758","DOIUrl":"10.1177/03000605251347758","url":null,"abstract":"<p><p>PurposeTo evaluate the efficacy and safety of ultrasound-guided percutaneous transluminal angioplasty for hemodialysis-associated venous hypertension syndrome caused by central venous stenosis or occlusion.Patients and methodsThe clinical data of 24 treatment instances with color duplex ultrasound-guided percutaneous transluminal angioplasty from January 2021 to January 2023 were retrospectively analyzed. The primary endpoint of the study was clinical success rate, while the secondary endpoints were 6- or 12-month vascular patency rates.ResultsOf the 24 treatment instances enrolled, 20 were primary onset and treated initially with percutaneous transluminal angioplasty under color duplex ultrasound guidance. Of these 20 patients, 17 were treated successfully (85%), while 3 procedures failed, requiring reoperation. Six patients showed recurrence within 1 year, of which four received repeated ultrasound-guided percutaneous transluminal angioplasty. Three of these procedures were successful (75.0%). Therefore, the total success rate was 83.3%. The patency rates were 76.5% at the 6-month follow-up and 64.7% at the 12-month follow-up. No patient developed complications such as dissection or perforation of the target vessel wall.ConclusionColor duplex ultrasound-guided percutaneous transluminal angioplasty is a feasible technique for hemodialysis-associated venous hypertension syndrome.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251347758"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial multiple impacted supernumerary teeth: Case report.","authors":"Loulwah K Alothman, Azizah F Bin Mubayrik, Reema Alshawaf, Randa Alfotawi, Abdulaziz S Alqahtani","doi":"10.1177/03000605251339146","DOIUrl":"10.1177/03000605251339146","url":null,"abstract":"<p><p>Multiple impacted supernumerary teeth are rare and need a multidisciplinary approach for optimal management to reduce potential complications. Herein, we present the case of an otherwise generally healthy woman in her early 30s who presented to the oral medicine clinic with a chief complaint of multiple missing teeth. Family history revealed that her sister and brother had the same complaint. Panoramic and cone-beam computed tomography radiographic findings revealed the presence of multiple impacted supernumerary teeth in both jaws. Multiple radiopacities and frontal sinus osteoma were noted. The radiographic features were suggestive of Gardner syndrome. An endoscopy was requested, which turned out negative for any polyps, with a recommendation to repeat endoscopy after 10 years. This is because the cranial osteoma might precede the gastrointestinal polyposis. A comprehensive treatment plan was performed by a team of dentists from multiple specialties (oral medicine, oral radiology, orthodontics, prosthodontics, and oral surgery) to ensure optimal outcomes for the patient. Thus, it is essential for dentists to identify and explore any atypical findings that may arise during clinical examination.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251339146"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uni-portal non-coaxial spinal endoscopic surgery combined with annulus fibrosus suture technique for lumbar disc herniation: Case series.","authors":"Yongneng Li, Lihui Fu, Yongqiang Yang, Shuwen Kan, En Song","doi":"10.1177/03000605251351726","DOIUrl":"10.1177/03000605251351726","url":null,"abstract":"<p><p>ObjectiveTo investigate the clinical efficacy of uni-portal non-coaxial spinal endoscopic surgery combined with Polysorb 4-0 absorbable sutures for repairing ruptured annulus fibrosus in the treatment of lumbar disc herniation.MethodsWe conducted a retrospective study involving 201 patients who underwent uni-portal non-coaxial spinal endoscopic surgery from May 2023 to August 2024 at our institution. Among these patients, 22 were treated using ligamentum flavum suspension surgery while preserving the ligamentum flavum, combined with the annulus fibrosus suture technique. We analyzed the demographic information, preoperative and postoperative imaging data, and clinical outcomes of these 22 patients.ResultsThese 22 patients were followed for 6-15 months; at the last follow-up, the improvement in postoperative functional evaluations, such as the Oswestry Disability Index, was statistically significant (P < 0.05). There were two cases of epidural fibrosis at grade 1 and one case of epidural fibrosis at grade 2. There was a slight decrease in disk height. There were no instances of postoperative recurrence, although one patient exhibited postoperative dysesthesia.ConclusionUni-portal non-coaxial spinal endoscopic surgery is straightforward, versatile, and flexible. Preservation of the ligamentum flavum significantly helps prevent epidural fibrosis. Employing Polysorb 4-0 absorbable sutures to repair the annulus fibrosus reduces early recurrence risk, providing satisfactory outcomes for patients with herniated discs. This technique offers a novel and effective treatment alternative for lumbar disc herniation.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251351726"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary squamous cell carcinoma of the pancreas with treatment-refractory characteristics: A case report and literature review.","authors":"Jian Wang, Dingting Zheng, Jianxin Chen","doi":"10.1177/03000605251345957","DOIUrl":"10.1177/03000605251345957","url":null,"abstract":"<p><p>Primary squamous cell carcinoma of the pancreas is sporadic and rarely reported. This uncommon disease is characterized by rapid proliferation, high aggressiveness, and poor prognosis. To date, no standard treatment regimen has been established for this malignancy. The present study reported on a patient diagnosed with primary squamous cell carcinoma of the pancreas who showed recurrence after radical resection and adjuvant chemotherapy. The patient was refractory to salvage therapy with cytotoxic drugs, anti-angiogenesis drugs, and even immune checkpoint inhibitors, resulting in a poor prognosis. Notably, the Ki-67 proliferation index, a marker of tumor cell proliferation, increased from 40% in the surgical specimen to 80% in the recurrent tumor within 2 months. In addition, the literature on clinical characteristics as well as treatment options and their efficacy in patients with squamous cell carcinoma of the pancreas was reviewed and summarized to improve the understanding of the disease and treatment choices. This case report offers valuable insights into squamous cell carcinoma of the pancreas progression and underscores the need for further research on this aggressive malignancy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251345957"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the diagnostic performance of ultrasound for clavicle fractures in emergency settings: A meta-analysis and systematic review.","authors":"Bin Lin, Danqin Yuan, Weiting Chen, Ying Liu, Xiaozhen Ji","doi":"10.1177/03000605251351273","DOIUrl":"10.1177/03000605251351273","url":null,"abstract":"<p><p>ObjectiveUltrasound provides real-time, high-resolution imaging and is increasingly recognized as a valuable diagnostic tool for clavicle fractures. Compared with traditional imaging modalities, ultrasound offers advantages such as point-of-care accessibility, absence of radiation exposure, and rapid diagnosis capability, making it particularly useful in emergency settings. However, the diagnostic performance of ultrasound across different clinical studies remains inconsistent. Therefore, this study aimed to systematically assess the diagnostic accuracy of ultrasound for clavicle fractures through a meta-analysis of existing studies.MethodsA systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. A comprehensive search of PubMed, Scopus, Embase, Cochrane Library, and Web of Science was performed until 25 February 2025. Studies reporting the sensitivity, specificity, and overall diagnostic performance of ultrasound for clavicle fractures were included. Data extraction and statistical analysis were performed using Stata version 18.0.ResultsA meta-analysis of seven eligible studies showed a pooled sensitivity of 92% (95% confidence interval: 87%-95%) and pooled specificity of 95% (95% confidence interval: 91%-98%), indicating relatively high diagnostic accuracy. Sensitivity showed low-to-moderate heterogeneity, whereas specificity demonstrated significant heterogeneity. Fagan plot and likelihood ratio analysis supported the clinical utility of ultrasound for both confirming and excluding clavicle fractures. The likelihood ratio scattergram indicated that ultrasound shows good performance in ruling in clavicle fractures but only moderately good performance in ruling them out.ConclusionCurrent evidence indicates that ultrasound is a promising, noninvasive diagnostic modality for clavicle fractures, especially in emergency settings. Its diagnostic accuracy, coupled with its safety profile, makes it a potentially valuable tool. Nevertheless, standardization of scanning protocols and further validation in diverse populations are needed. Future studies are warranted to standardize scanning protocols, evaluate operator-dependent factors, and validate findings across broader clinical settings.<b>Trial registration number:</b> PROSPERO CRD: 42025643069.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251351273"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A four-year follow-up of Caplan's syndrome: A case report.","authors":"Ling Wang, Yanling Liu, Yibin Zhang, Yue Hu","doi":"10.1177/03000605251353738","DOIUrl":"10.1177/03000605251353738","url":null,"abstract":"<p><p>Caplan's syndrome, also known as rheumatoid pneumoconiosis, is characterized by pulmonary nodules and rheumatoid arthritis in patients with pneumoconiosis. Owing to its low incidence rate and the presence of multiple nodules on lung computed tomography, it is often mistaken for other pulmonary diseases. Herein, we report the case of a 60-year-old man who presented to the hospital with joint edema and recurrent polyarthralgia. Laboratory studies revealed higher levels of rheumatoid factor and anti-citrullinated peptide antibodies, together with an enhanced erythrocyte sedimentation rate. Chest high-resolution computed tomography revealed multiple bilateral nodules during the evaluation for treatment contraindications. Based on the patient's occupational background and findings from multidisciplinary consultations, a definitive diagnosis of Caplan syndrome was made. Maintenance therapy included low-dose methylprednisolone (gradually tapered and discontinued over 3 months), methotrexate, and hydroxychloroquine. The patient's arthralgia and pulmonary nodules demonstrated stability over a follow-up period of up to 4 years, thereby indicating the success of this treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251353738"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting drug-drug interactions and optimal dosing of betrixaban with physiologically based pharmacokinetic modeling in patients with renal impairment who were coadministered with P-glycoprotein inhibitors.","authors":"Xiaoping Yan, Lirong Xiao, Weina Xie","doi":"10.1177/03000605251346587","DOIUrl":"10.1177/03000605251346587","url":null,"abstract":"<p><p>ObjectiveTo optimize dosing adjustments in patients with renal impairment who were coadministered with P-glycoprotein inhibitors-verapamil or amiodarone-using a physiologically based pharmacokinetic model.MethodsThe developed physiologically based pharmacokinetic model was corroborated using previously reported pharmacokinetic parameters across multiple doses, ratio values in drug-drug interactions, and pharmacokinetic ratio values in patients with renal impairment.ResultsThe physiologically based pharmacokinetic model exhibited fold errors between 0.7 and 1.3 and effectively illustrated changes in pharmacokinetic ratios in patients with renal impairment. The model suggested that the dosing regimen of betrixaban should be reduced to 40 mg once daily in patients with mild renal impairment who were administered with verapamil or amiodarone. Additionally, it is advised that the dosing regimen of betrixaban be reduced to 40 mg once daily in patients with moderate renal impairment who were administered with amiodarone, whereas no suitable dosing is recommended for those administered with verapamil. For patients with severe renal impairment, it may be reasonable to avoid concurrent use of betrixaban with P-glycoprotein inhibitors.ConclusionsThe coadministration of P-glycoprotein inhibitors elevates the exposure of betrixaban and may heighten the risk of major bleeding. Reduced dosing regimens are recommended for patients with renal impairment when betrixaban is coadministered with P-glycoprotein inhibitors.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251346587"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival of a patient with glioblastoma multiforme after undergoing bone flap surgery followed by chemoradiotherapy to maintain tumor-treating fields: A case report.","authors":"Hongli Yang, Lijun Wang, Jiezhou Zheng, Mengqi Sun, Zihuang Li","doi":"10.1177/03000605251343020","DOIUrl":"10.1177/03000605251343020","url":null,"abstract":"<p><p>The efficacy of sequential adjuvant chemotherapy after concurrent chemoradiotherapy in older patients with glioblastoma multiforme is limited. Previous studies have reported that controlling tumor recurrence by increasing the electric field intensity in the tumor region can extend the survival of older patients with glioblastoma multiforme. This report describes the case of a woman with glioblastoma multiforme in her early 60s from China who was initially admitted to Shenzhen People's Hospital with impaired consciousness and limb weakness. Based on her medical history and magnetic resonance imaging findings, she was diagnosed with glioblastoma multiforme with subfalcine herniation. After undergoing decompressive craniectomy in addition to receiving concurrent radiotherapy and chemotherapy, she achieved long-term survival benefits by maintaining tumor electric field therapy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 6","pages":"3000605251343020"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}