Journal of International Medical Research最新文献_第3页

Autoimmune encephalitis following treatment with durvalumab for small-cell lung cancer. 使用durvalumab治疗小细胞肺癌后出现自身免疫性脑炎。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241287015

Yu-Lan Qian, Ye Jiang, Yin-Hua Gong, Jian-Kang Yu, Chao Liu, Wen-Ting Wu, Dan Shen

引用次数: 0

Squamous cell carcinoma of the cervix associated with choriocarcinomatous differentiation: a case report and review of the literature. 宫颈鳞状细胞癌伴有绒毛状癌分化：病例报告和文献综述。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241283632

Fenfen Wang, Shanshan Xu, Xiaofei Zhang, Yeqing Qian, Yaxia Chen

{"title":"Squamous cell carcinoma of the cervix associated with choriocarcinomatous differentiation: a case report and review of the literature.","authors":"Fenfen Wang, Shanshan Xu, Xiaofei Zhang, Yeqing Qian, Yaxia Chen","doi":"10.1177/03000605241283632","DOIUrl":"10.1177/03000605241283632","url":null,"abstract":"The morphology of the choriocarcinomatous variant of cervical squamous cell carcinoma (SCC) suggests an undifferentiated aggressive biological behaviour and a poor outcome, for which standard treatment has not been established. In addition, cases are rarely reported, with only five cases of patients with cervical carcinoma with choriocarcinoma reported previously in the literature. This current case report describes in detail a patient who was diagnosed with cervical SCC mixed with choriocarcinomatous differentiation. The case report includes details of the diagnosis, pathology, short tandem repeat genotyping, treatment and follow-up of this patient. As there is no standard treatment for this variant, the patient underwent surgery followed by radiotherapy. Unfortunately, 4 months after therapy discontinuation, radiological evaluation and laboratory tests documented a recurrence of the disease and the patient died. This report also systematically reviews the literature on cervical cancer associated with choriocarcinomatous differentiation and the five previous cases. It provides the most up-to-date summary of this disease, including its clinical manifestations, histopathology, diagnosis, treatment and prognosis.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11456200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical value of a radiomics model based on machine learning for the prediction of prostate cancer. 基于机器学习的放射组学模型对前列腺癌预测的临床价值。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241275338

Zhen-Lin Chen, Zhang-Cheng Huang, Shao-Shan Lin, Zhi-Hao Li, Rui-Ling Dou, Yue Xu, Shao-Qin Jiang, Meng-Qiang Li

{"title":"Clinical value of a radiomics model based on machine learning for the prediction of prostate cancer.","authors":"Zhen-Lin Chen, Zhang-Cheng Huang, Shao-Shan Lin, Zhi-Hao Li, Rui-Ling Dou, Yue Xu, Shao-Qin Jiang, Meng-Qiang Li","doi":"10.1177/03000605241275338","DOIUrl":"10.1177/03000605241275338","url":null,"abstract":"Objective: Radiomics models have demonstrated good performance for the diagnosis and evaluation of prostate cancer (PCa). However, there are currently no validated imaging models that can predict PCa or clinically significant prostate cancer (csPCa). Therefore, we aimed to identify the best such models for the prediction of PCa and csPCa.Methods: We performed a retrospective study of 942 patients with suspected PCa before they underwent prostate biopsy. MRI data were collected to manually segment suspicious regions of the tumor layer-by-layer. We then constructed models using the extracted imaging features. Finally, the clinical value of the models was evaluated.Results: A diffusion-weighted imaging (DWI) plus apparent diffusion coefficient (ADC) random-forest model and a T2-weighted imaging plus ADC and DWI multilayer perceptron model were the best models for the prediction of PCa and csPCa, respectively. Areas under the curve (AUCs) of 0.942 and 0.999, respectively, were obtained for a training set. Internal validation yielded AUCs of 0.894 and 0.605, and external validation yielded AUCs of 0.732 and 0.623.Conclusion: Models based on machine learning comprising radiomic features and clinical indicators showed good predictive efficiency for PCa and csPCa. These findings demonstrate the utility of radiomic models for clinical decision-making.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenomatoid tumor of the uterus: analysis of misdiagnosed cases and a literature review. 子宫腺瘤：误诊病例分析和文献综述。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241282389

Yan-Yu Li, Guang-Juan Kan, Qian Wang, Song Guo, Chen-Xi Wu, Jiang Zhu

{"title":"Adenomatoid tumor of the uterus: analysis of misdiagnosed cases and a literature review.","authors":"Yan-Yu Li, Guang-Juan Kan, Qian Wang, Song Guo, Chen-Xi Wu, Jiang Zhu","doi":"10.1177/03000605241282389","DOIUrl":"10.1177/03000605241282389","url":null,"abstract":"Adenomatoid tumors are rare, specific, benign tumors of the reproductive tract that originate from mesenchymal tissue. A patient was diagnosed with uterine fibroids 1 year previously when a mass of approximately 30 mm was found in the left adnexal region during a physical examination. At 1 year of follow-up, ultrasound showed that the mass in the left adnexal area had greatly increased to 61 × 45 × 50 mm. Contrast-enhanced pelvic magnetic resonance imaging (MRI) was performed before surgery and suggested a borderline tumor. Histopathology suggested signet ring cell carcinoma, and an immunohistochemical examination suggested a uterine adenomatoid tumor. Our suspicion of a borderline tumor was based mainly on the following features: the mass had increased in size within 1 year, the cancer antigen 125 concentration had increased, and several lymph nodes in the pelvic and groin regions showed positive signals on MRI enhancement. Uterine adenomatoid tumors are challenging to diagnose, especially adenomatosis with signet ring cells. However, the accuracy of diagnosing this disease can be greatly improved by combining ultrasound and MRI. This article describes the most comprehensive and reliable imaging features of ultrasound and MRI, which play an important role in diagnosing uterine adenomatoid tumors and provide useful information for clinicians.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of rigid plate fixation for sternal closure in patients with a high risk of deep sternal wound infection. 对胸骨深部伤口感染风险较高的患者采用硬板固定进行胸骨闭合的效果。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241281915

Hiromasa Nakamura, Yujiro Miura, Keisuke Yoshida, Naoki Edo, Ren Saito, Kazumasa Orihashi

{"title":"Effectiveness of rigid plate fixation for sternal closure in patients with a high risk of deep sternal wound infection.","authors":"Hiromasa Nakamura, Yujiro Miura, Keisuke Yoshida, Naoki Edo, Ren Saito, Kazumasa Orihashi","doi":"10.1177/03000605241281915","DOIUrl":"10.1177/03000605241281915","url":null,"abstract":"Objective: Median sternotomy is a standard approach in cardiovascular surgery, and wire fixation is commonly used for sternal closure. However, postoperative intermittent stress on the sternum can lead to sternal breakdown, potentially resulting in deep sternal wound infection (DSWI). Sternal closure with rigid plate fixation was recently reported to be effective for preventing DSWI and promoting sternal healing. We investigated the effectiveness of a rigid plate fixation system in patients at a high risk of developing DSWI.Methods: This retrospective observational study evaluated the incidence of DSWI and the progression of postoperative sternal fusion observed on computed tomography. Forty-eight patients at a high risk of DSWI who underwent sternal closure with a rigid plate fixation system between 2020 and 2023 were assessed.Results: Among the 48 patients, 1 (2.1%) developed DSWI requiring surgical treatment. Sternal fusion improved over time, with significant progression observed during the follow-up period compared with the early postoperative period. Additionally, patients who did not show sternal fusion in the early postoperative period showed progressive fusion during follow-up.Conclusions: The rigid plate fixation system prevents sternal displacement and may be beneficial in preventing DSWI by maintaining and promoting sternal fusion in high-risk patients.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between sphenoid sinus pneumatization and sella turcica dimensions using computed tomography. 使用计算机断层扫描检查蝶窦积气与蝶窦尺寸之间的相关性。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241287021

Nuhad A Hassan, Mais Ah Mahdi, Noor S Irhyyim

{"title":"Correlation between sphenoid sinus pneumatization and sella turcica dimensions using computed tomography.","authors":"Nuhad A Hassan, Mais Ah Mahdi, Noor S Irhyyim","doi":"10.1177/03000605241287021","DOIUrl":"10.1177/03000605241287021","url":null,"abstract":"Objective: This study was performed to determine the dimensions of the sella turcica (ST) in relation to sex, age groups, and sphenoid sinus (SS) pneumatization patterns in a cohort of Iraqi individuals.Methods: This cross-sectional study analyzed computed tomography images of 99 individuals (53 men, 46 women) aged 24 to 59 years to measure ST dimensions, including length, width, height, depth, and surface area. SS pneumatization was classified by sex and age. We also examined the relationship between ST size and SS pneumatization patterns.Results: Women exhibited a significantly greater mean ST depth (9.37 mm) than men (8.19 mm). The ST diameter was significantly larger in the middle-aged group (13.1 mm) than in the young adult group (11.83 mm). The ST area showed a highly significant difference between sexes. The sellar pneumatization pattern was the most common, whereas the conchal pattern had the lowest prevalence. A significant correlation was observed between ST size and SS pneumatization.Conclusion: The ST depth and diameter showed statistically significant differences across sex and age groups, respectively. The variability in SS pneumatization patterns underscores the importance of considering pneumatization types during surgical planning to minimize the risk of iatrogenic injury and improve treatment outcomes.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of transcranial electrical stimulation on post-stroke dysphagia: a systematic review and meta-analysis. 评估经颅电刺激对中风后吞咽困难的影响：系统回顾和荟萃分析。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241288843

Yanan Zhao, Zhicheng Zhang, Cuicui Wang, Hui Zhang, Ying Wang, Jing Bian

{"title":"Evaluating the impact of transcranial electrical stimulation on post-stroke dysphagia: a systematic review and meta-analysis.","authors":"Yanan Zhao, Zhicheng Zhang, Cuicui Wang, Hui Zhang, Ying Wang, Jing Bian","doi":"10.1177/03000605241288843","DOIUrl":"10.1177/03000605241288843","url":null,"abstract":"Objective: To conduct a systematic review and meta-analysis to assess the impact of transcranial electrical stimulation (TES), proposed as a potential therapy for post-stroke dysphagia, on swallowing function in stroke survivors.Methods: The PubMed, Embase, Web of Science, and Cochrane Library databases were searched for relevant studies on TES for post-stroke dysphagia. Search results were reviewed following PRISMA guidelines, and the following data were extracted from included studies: study characteristics, demographics, and outcomes. Bias was assessed using the Cochrane tool. Heterogeneity and effect sizes were analysed using I2 statistics and appropriate effects models. The study protocol was registered with PROSPERO (registration No. CRD42024578243).Results: Six randomized controlled trials met the inclusion criteria (I2 = 0.0%). The meta-analysis indicated a significant improvement in dysphagia with TES (standardized mean difference [SMD] 0.43, 95% confidence interval [CI] 0.13, 0.73). Subgroup analysis suggested that low-intensity TES was effective (SMD 0.46, 95% CI 0.09, 0.82), whereas high-intensity TES showed no significant improvement (SMD 0.37, 95% CI -0.17, 0.91). No publication bias was detected.Conclusion: TES may improve swallowing in stroke patients, with potential benefits from low-intensity protocols.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of microRNAs on cardiovascular diseases and aging. 微小核糖核酸对心血管疾病和衰老的影响。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241279190

Md Sayed Ali Sheikh, Umme Salma

{"title":"Impact of microRNAs on cardiovascular diseases and aging.","authors":"Md Sayed Ali Sheikh, Umme Salma","doi":"10.1177/03000605241279190","DOIUrl":"10.1177/03000605241279190","url":null,"abstract":"Cardiovascular disease (CVD) is the leading cause of morbidity and mortality for both men and women among all ethnicities worldwide. Although significant improvements in the management of CVD occurred in the 20th century, non-invasive, universal, early diagnostic biomarkers and newer therapeutic drugs are needed for clinical treatment by physicians. MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded, small RNA molecules that are critically controlled by all human biological processes. Moreover, dysregulated miRNA expression is directly involved in various CVDs, including stable coronary artery disease and acute coronary syndrome. Several miRNAs that are enriched in the plasma of CVD patients have potential as clinical biomarkers, and overexpression or inhibition of specific miRNAs has novel therapeutic significance in the management of CVD. Aging is a multifactorial physiological process that gradually deteriorates tissue and organ function and is considered a non-modifiable major risk factor for CVDs. Recently, several studies established that various miRNAs essentially regulate aging and aging-related disease processes. This narrative review briefly discusses the recently updated molecular involvement of miRNAs in CVDs, their possible diagnostic, prognostic, and therapeutic value, and their relationship to the aging process.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regional nerve blocks for peripheral neuropathy: a rare clinical case report. 区域神经阻滞治疗周围神经病变：罕见临床病例报告。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241282248

Jianwei Guo, Yan Cheng, Minmin Yi

引用次数: 0

Association between haemoglobin decline and long-term outcomes in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention. 接受经皮冠状动脉介入治疗的 ST 段抬高型心肌梗死 (STEMI) 患者血红蛋白下降与长期预后之间的关系。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241285241

Fatma Esin, Hüseyin Sefa Ince, Gökhun Akkan, Ugur Kocabas, Tuncay Kiris, Aykan Celik, Mustafa Karaca

{"title":"Association between haemoglobin decline and long-term outcomes in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention.","authors":"Fatma Esin, Hüseyin Sefa Ince, Gökhun Akkan, Ugur Kocabas, Tuncay Kiris, Aykan Celik, Mustafa Karaca","doi":"10.1177/03000605241285241","DOIUrl":"https://doi.org/10.1177/03000605241285241","url":null,"abstract":"Objective: To explore the association between in-hospital haemoglobin decline and long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) among ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).Methods: This retrospective analysis included adult patients who underwent primary PCI for STEMI. Haemoglobin levels were recorded at admission and 48-72 h later. Patients were divided into two groups based on the extent of haemoglobin decline: low (<3 g/dl or no decline) and high (≥3 g/dl). The primary endpoint was all-cause mortality at long-term follow-up. The secondary endpoint was MACCE.Results: Patients were divided into two groups: low group (n = 665) and high group (n = 111). The mortality rate was significantly higher in the high group (72 of 111 patients; 65%) than in the low group (185 of 655 patients; 28%). Propensity score matching confirmed this association, with higher mortality (41 of 79 patients [52%] versus 25 of 79 patients [32%]) and MACCE rates (56 of 79 patients [71%] versus 41 of 79 patients [52%]) in the high group compared with the low group, respectively.Conclusion: There was a significant association between in-hospital haemoglobin decline, even without visible bleeding, and increased long-term mortality and MACCE in STEMI patients undergoing primary PCI.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0