Journal of International Medical Research最新文献

{"title":"Sponge cytology combined with endoscopy in patients with long-segment Barrett's esophagus: A retrospective case series and literature review.","authors":"Ling Sun, Wen J-Ao, Hao Q-Zhi, Wuri N-Bai, Fan Yu, Quan Man, Hui F-Pang","doi":"10.1177/03000605251378944","DOIUrl":"10.1177/03000605251378944","url":null,"abstract":"<p><p>This study summarized the clinical characteristics and endoscopic findings in patients with long-segment Barrett's esophagus through a retrospective analysis of the clinical data of three patients with long-segment Barrett's esophagus. Data from patients, including demographic characteristics, medical history, endoscopy findings, pathological diagnosis, and esophageal sponge cytology results were analyzed, and a literature review was performed. Three patients were included; all were male with a mean age of 67.3 ± 7.1 years. Symptoms encompassed heartburn (3/3), acid reflux (2/3), belching (1/3), retrosternal pain (1/3), abdominal distension (1/3), and dysphagia (1/3). Risk factors included alcohol use (3/3), consumption of pickled and hot foods or beverages (3/3), smoking (1/3), and familial esophageal disease history (1/3). Endoscopically, Prague C & M criteria measurements were C₁₃M₁₅, C₄M₁₀, and C₆M₇, with long-segment Barrett's esophagus lesions spanning the upper/middle/lower esophagus; all showed circumferential involvement and coexisted with gastroesophageal reflux disease. Concurrently, two patients presented with all the following three conditions: hiatal hernia, chronic atrophic gastritis, and <i>Helicobacter pylori</i> infection. Pathologically, one patient showed early intramucosal adenocarcinoma, whereas two had intestinal metaplasia. Sponge cytology identified grade 3 atypical cells in one patient and grade 2 hyperplasia in two patients. In conclusion, long-segment Barrett's esophagus is strongly associated with gastroesophageal reflux disease and necessitates endoscopic surveillance, whereas sponge cytology screening has shown initial feasibility but requires standardized protocols and multicenter validation for clinical integration.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378944"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of overweight and obese critically ill patients with severe acute respiratory infection.","authors":"Abdurahman Najy Ayoup, Haytham Tlayjeh, Jesna Jose, Farhan Zayed Alenezi, Musharaf Sadat, Felwa Bin Humaid, Fahad Al-Hameed, Kasim Al Khatib, Shawgi Osman Mohammed Omer, Haifa AlHumedi, Samiyah Alrawy Alanazi, Nahlah Awadh Albaalharith, Yaseen M Arabi","doi":"10.1177/03000605251370302","DOIUrl":"10.1177/03000605251370302","url":null,"abstract":"<p><p>ObjectivesTo assess the association of obesity with outcomes among patients with severe acute respiratory infection.MethodsThis is a retrospective cohort study of patients with severe acute respiratory infection admitted to the intensive care units in four referral hospitals in Saudi Arabia between September 2012 and June 2018. Patients were classified into two groups: overweight-obese patients (body mass index  ≥25 kg/m²) and normal-weight patients (body mass index between 18.5 and 24.9 kg/m²). All underweight patients with a body mass index <18.5 kg/m² were excluded from the study.ResultsOf the 421 patients, 294 were in the overweight-obese group and 127 were in the normal-weight group. There was no difference in crude 90-day mortality between the two groups. However, multivariate regression analysis showed that overweight-obese patients had lower 90-day mortality than normal-weight patients (odds ratio, 0.71; 95% confidence interval, 0.60-0.85; <i>P</i> = 0.0002). Interestingly, increasing age was associated with a significant increase in mortality (odds ratio, 1.03; 95% confidence interval, 1.02-1.03; <i>P</i> < 0.0001). Moreover, the Sequential Organ Failure Assessment score was associated with a significant increase in mortality (odds ratio, 1.21; 95% confidence interval, 1.15-1.26; <i>P</i> < 0.0001).DiscussionOur study showed lower mortality among overweight-obese patients, supporting the phenomenon of obesity paradox.ConclusionOverweight and obesity were common among patients with severe acute respiratory infection. Our study demonstrates that the obesity paradox exists among patients with severe acute respiratory infection.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251370302"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A predictive nomogram for peritoneal injury during totally extraperitoneal inguinal hernia repair: A retrospective cohort study.","authors":"Jingbin Wang, Yuanfang Sun, Yanhao Sun","doi":"10.1177/03000605251372434","DOIUrl":"10.1177/03000605251372434","url":null,"abstract":"<p><p>ObjectivePeritoneal injury is a common complication during totally extraperitoneal inguinal hernia repair, potentially affecting surgical outcomes and patient recovery. Identifying risk factors associated with peritoneal injury is crucial to improving surgical techniques and optimizing patient care.MethodsThis retrospective study analyzed data from 334 patients who underwent totally extraperitoneal inguinal hernia repair between August 2019 and April 2024. Patients were divided into two groups based on the occurrence of peritoneal injury: injury group (<i>n</i> = 69) and noninjury group (<i>n</i> = 265). Univariate and multivariate logistic regression analyses identified independent risk factors for peritoneal injury. A predictive nomogram was constructed using significant variables from the multivariate analysis. The performance of the nomogram was evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis.ResultsPeritoneal injury occurred in 20.7% of the cases. Multivariate analysis identified the following five independent risk factors: anatomical misrecognition (odds ratio: 7.55; p = 0.005), insufficient peritoneal tension (odds ratio: 2.95; p = 0.007), hernial sac diameter ≥4 cm (odds ratio: 2.75; p = 0.008), prior infraumbilical surgery (odds ratio: 2.50; p = 0.021), and use of sharp medial hernia sac dissection techniques (odds ratio: 5.20; p = 0.006). Body mass index was a significant factor in univariate analysis (p = 0.004) but not in multivariate analysis (p = 0.180). The nomogram demonstrated good discriminative ability (AUC = 0.841) and calibration. The decision curve analysis indicated that the nomogram provided clinical utility across a range of threshold probabilities.ConclusionsThe study identified key risk factors for peritoneal injury during totally extraperitoneal inguinal hernia repair and developed a predictive nomogram with strong discriminative ability. Awareness of these factors enables surgeons to preoperatively stratify risk based on imaging-assessed hernia characteristics and patient history, thereby guiding technique selection.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372434"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile dysfunction among the young male population: A cross-sectional study.","authors":"Emad Sabri Rajih, Khalid Abdul Hameed Shaht","doi":"10.1177/03000605251370327","DOIUrl":"10.1177/03000605251370327","url":null,"abstract":"<p><p>ObjectiveThis study aimed to assess the prevalence and associated factors of male sexual dysfunction in a population of young men using validated tools to evaluate erectile function and its contributing factors.MethodsA community-based cross-sectional study was conducted between April 2023 and August 2024 among married men aged ≤40 years in Saudi Arabia. Participants were randomly selected from public gatherings across five regions and interviewed using the International Index of Erectile Function and Sexual Health Inventory for Men. Sociodemographic and clinical data were collected, including comorbidities, body mass index, physical activity, income, educational level, job, and depression screening result. Statistical analyses included descriptive statistics, nonparametric tests, and multivariable linear regression to identify factors associated with erectile dysfunction.ResultsA total of 196 men participated in the study. Of these, 77 (39.2%) were diagnosed with erectile dysfunction. According to the Sexual Health Inventory for Men score categories, 119 (60.7%) men had no significant erectile dysfunction, 29 (14.8%) had mild erectile dysfunction, 19 (9.7%) had mild-to-moderate erectile dysfunction, 15 (7.6%) had moderate erectile dysfunction, and 14 (7.14%) had severe erectile dysfunction. Multivariable linear regression analysis revealed several significant associated factors for better erectile function (based on the International Index of Erectile Function score), namely, higher income and an initial negative screening result for depression. The International Index of Erectile Function score was 12.65 points (95% confidence interval: -17.37 to -7.92; p < 0.0001) lower in participants with an initial positive screening result for depression than in those with an initial negative screening result for depression.ConclusionsThese results suggest that sexual dysfunction in younger men is not only influenced by physical health but also closely linked to psychosocial factors such as low income and depression. Further longitudinal research and multidisciplinary approaches are required to develop comprehensive targeted interventions for sexual dysfunction in young men, with an emphasis on mental health and socioeconomic conditions.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251370327"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based prognostic model for human immunodeficiency virus-associated cutaneous T-cell lymphoma: A Surveillance, Epidemiology, and End Results database analysis.","authors":"Weimin Huang, Manwen Tian, Lanlan Jia, Jing Ai, Jinying Gan, Junteng Chen, Lingzhen Chen, Yongmin Zhang","doi":"10.1177/03000605251359433","DOIUrl":"10.1177/03000605251359433","url":null,"abstract":"<p><p>ObjectiveAccurate prognostication is crucial for managing human immunodeficiency virus (HIV)-associated cutaneous T-cell lymphoma. In this study, we aimed to develop an improved machine learning-based prognostic model for predicting the 5-year survival rates in HIV-associated cutaneous T-cell lymphoma patients.MethodsWe derived and tested machine learning models using algorithms including Extreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), and Random Forest. Our study involved data from a US population-based cohort of patients diagnosed with HIV-associated cutaneous T-cell lymphoma between 1 January 2000 and 31 December 2018, which were extracted from the Surveillance, Epidemiology, and End Results database. The primary outcome was the prediction of 5-year overall survival. Model discrimination was assessed using the area under the receiver operating characteristic curve (AUC), and calibration was assessed using Brier scores.ResultsA cohort of 381 HIV-associated cutaneous T-cell lymphoma patients was analyzed. Multivariate logistic regression identified age ≥60 years (odds ratio = 4.88), regional stage (odds ratio = 10.31), distant stage (odds ratio = 28.37), and chemotherapy (odds ratio = 4.71) as significant independent risk factors for 5-year mortality. Among seven machine learning models developed, the XGBoost model demonstrated the highest discrimination for 5-year overall survival (AUC = 0.867), followed by LightGBM (AUC = 0.835). Both models exhibited good calibration with low Brier scores (XGBoost = 0.130, LightGBM = 0.109). Support Vector Machine performed optimally in ten-fold cross-validation, logistic regression showed the lowest Brier score (0.106), and XGBoost provided the best balance of discrimination and robust performance.ConclusionOur novel machine learning approach produced prognostic models with superior discrimination for 5-year overall survival in HIV-associated cutaneous T-cell lymphoma patients using standard clinicopathological variables. These models offer potential for more accurate and personalized prognostics, potentially improving patient management and clinical decision-making.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251359433"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of environmental metal mixtures on chronic kidney disease risk: Insights from the National Health and Nutrition Examination Survey 2011-2016.","authors":"Sen Zhang, XiaoJuan Fu","doi":"10.1177/03000605251378695","DOIUrl":"10.1177/03000605251378695","url":null,"abstract":"<p><p>BackgroundChronic kidney disease is a global health issue, with environmental metal mixtures potentially contributing to its risk, although interactions between metals remain unclear. The present study aims to systematically explore the association between exposure to environmental metal mixtures and the risk of chronic kidney disease as well as their potential interactive effects.MethodsData from 3514 adults (aged ≥20 years) who participated in the National Health and Nutrition Examination Survey 2011-2016 were analyzed. Blood concentrations of lead, cadmium, mercury, selenium, manganese, serum copper, and zinc were measured. Chronic kidney disease was defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m² or urinary albumin-creatinine ratio of ≥30 mg/g. Logistic regression, restricted cubic splines, weighted quantile sum, Bayesian kernel machine regression, and machine learning were used for data analysis.ResultsHigher concentrations of lead, cadmium, and copper were linked to an increased risk of chronic kidney disease; zinc showed protective effects. Weighted quantile sum indicated that exposure to metal mixtures was positively associated with chronic kidney disease risk (odds ratio: 1.58, 95% confidence interval: 1.30-1.94), with lead and cadmium showing the highest contribution. Bayesian kernel machine regression confirmed the cumulative/interactive effects of metals. XGBoost (area under the curve: 0.801) showed good predictive performance.ConclusionsEnvironmental metal mixtures, especially lead and cadmium, increase the risk of chronic kidney disease. Metal interactions modulate renal effects, highlighting the need for exposure reduction strategies.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251378695"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of remimazolam combined with alfentanil in flexible fiberoptic bronchoscopy: A randomized controlled trial.","authors":"Yuankai Lv, Gongchen Duan, Yini Wu, Jianxin Jiang, Minji You, Faxing Wang, Jimin Wu, Hong Dai","doi":"10.1177/03000605251372495","DOIUrl":"10.1177/03000605251372495","url":null,"abstract":"<p><p>ObjectiveThe sedation protocol for flexible fiberoptic bronchoscopy has long been a matter of inconclusiveness. The aim of this study was to evaluate the safety and efficacy of remimazolam combined with alfentanil in flexible fiberoptic bronchoscopy and provide insights for optimizing clinical anesthesia strategies.MethodsThis study was a randomized, single-blind controlled trial. A total of 118 patients who underwent flexible fiberoptic bronchoscopy were randomized into two groups (59 patients per group). Both groups received intravenous alfentanil 10 µg/kg 2 min before sedation treatment, followed by either 0.2 mg/kg remimazolam (Group R) or 2 mg/kg propofol (Group P). During the flexible fiberoptic bronchoscopy, the experimental drugs were administered in patients in each group as needed to maintain the depth of sedation (modified observer's assessment of alertness/sedation score ≤ 3). The primary outcome was the incidence of hypoxemia. The secondary outcomes included other safety outcomes and effectiveness outcomes.ResultsA total of 115 participants completed the study. Compared with Group P, the incidence of severe hypoxemia in Group R was lower (3.4% vs. 15.8%, <i>P </i>=<i> </i>0.029); the incidences of injection pain and hypotension in Group R were lower (10.3% vs. 33.3%, <i>P </i>=<i> </i>0.003); and the incidences of hypotension, dizziness, and grade of cough in Group R were lower (<i>P </i><<i> </i>0.05). The sedation success rate and sedation success rate at an induced dose were similar between Groups R and P (<i>P > </i>0.05). Compared with Group P, sedation recovery time in Group R was shorter, and the operator comfort scores and patient comfort scores in Group R were higher (<i>P </i><<i> </i>0.05).ConclusionsRemimazolam, when combined with alfentanil, has shown excellent clinical potential in flexible fiberoptic bronchoscopy. Compared with propofol, it significantly reduced the incidence of severe hypoxemia, injection pain, hypotension, dizziness, and intraoperative coughing while maintaining comparable sedation success rates. It also shortened recovery time and improved both operator and patient comfort scores. These results support remimazolam plus alfentanil as a safe, effective, and well-tolerated alternative sedation regimen in this setting.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372495"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cotton roll biting on pain perception during orthodontic bracket debonding using Weingart pliers: A randomized controlled trial.","authors":"Belal A Drmch, Kinda Sultan, Mohammad Y Hajeer, Shadi Azzawi, Ahamd S Burhan","doi":"10.1177/03000605251370333","DOIUrl":"10.1177/03000605251370333","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the effectiveness of biting on a cotton roll in reducing pain during metal bracket removal using a Weingart plier compared with the conventional method.MethodsThis two-arm, parallel-group, randomized controlled trial included 36 patients (11 males and 25 females) with a mean age of 20.5 ± 3.08 years (range: 16-25 years). The study was conducted among patients who had completed orthodontic treatment with a fixed appliance using MBT prescription 0.022-inch metal brackets featuring a single-mesh base (Pinnacle®, MBT compatible 0.022, OrthoTechnology™, Florida, USA), and they were referred for metal bracket debonding. Brackets were removed using a Weingart plier, and participants were randomly assigned to one of two groups: the open-mouth group and the biting-on-a-cotton-roll group. Pain intensity was assessed for each tooth using a visual analog scale (0-100 mm) immediately after each bracket removal. Pain levels were compared between the two groups, between the upper and lower jaws, and across sexes.ResultsPatients in both groups reported pain levels ranging from mild to mild-moderate, with lower mean pain levels observed in the biting-on-a-cotton-roll group compared with the open-mouth group. Significant differences in mean pain scores were found between the open-mouth group and biting-on-a-cotton-roll group in the upper and lower incisors (13.61 and 13.19, <i>P</i> < 0.001, respectively), upper and lower canines (4.03 and 3.61, <i>P</i> < 0.001, respectively), and upper and lower premolars (12.78 and 11.11, <i>P</i> < 0.001, respectively). No significant differences in pain perception were observed between males and females across all regions (<i>P</i> > 0.05).ConclusionsBiting on a cotton roll significantly reduces pain during metal bracket debonding in the upper and lower incisor regions. The anterior regions of both jaws exhibit increased sensitivity to pain during the debonding procedure, whereas no differences in pain perception were observed between male and female patients.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251370333"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy plus surgery in advanced ovarian cancer patients.","authors":"Chang Yanan, Liu Ting, Cao Wei Li, Xu Yaxin, Chen Hong","doi":"10.1177/03000605251372415","DOIUrl":"10.1177/03000605251372415","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC) in patients with advanced ovarian cancer.MethodsA total of 200 patients with advanced ovarian cancer were enrolled in this retrospective study and randomly allocated to two groups (research registry number: 11353). On the first day after abdominal closure, routine treatment was performed in the non-HIPEC group, whereas HIPEC was performed in the HIPEC group. The surgical outcomes, overall survival, progression-free survival, side effects, and quality of life of patients were compared between the two groups, and the risk factors for overall survival and progression-free survival were analyzed.ResultsThe basic information of the patients showed no significant difference between the two groups (p > 0.05). There was no significant difference in the time from surgery to first flatus, postoperative hospital stay, abdominal pain, bleeding, leakage, or other blood indices between the two groups (p<i> </i>><i> </i>0.05); however, the symptoms of ileus and pelvic abscess appeared more frequently in the non-HIPEC group (p<i> </i><<i> </i>0.05). HIPEC, tumor size, N stage, T stage, and vascular invasion were significant indicators, while HIPEC, tumor size, vascular invasion, N stage, and T stage were independent prognostic factors. The 3-year survival rate of the HIPEC group (42%) was higher than that of the non-HIPEC group (21%) (p<i> </i><<i> </i>0.001). The progression-free survival curve of the HIPEC group was superior to that of the non-HIPEC group (p<i> < </i>0.001), and the recurrence rate of the HIPEC group (25%) was lower than that of the non-HIPEC group (49%) (p<i> < </i>0.001).ConclusionsHIPEC can reduce the possibility of perioperative complications such as intestinal obstruction and pelvic abscess, and the overall survival and progression-free survival curves were better in the HIPEC group.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251372415"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retroperitoneal ectopic pregnancy localized to the mesorectum: A case report and mini-review of literature.","authors":"Junpeng Liu, Lianzi Liu, Yue Yu, Zhenwei Miao","doi":"10.1177/03000605251375215","DOIUrl":"10.1177/03000605251375215","url":null,"abstract":"<p><p>Retroperitoneal ectopic pregnancy is an extremely rare form of ectopic pregnancy that can be life-threatening due to severe intra-abdominal hemorrhage. Retroperitoneal ectopic pregnancy is frequently misdiagnosed because of its atypical location and nonspecific symptoms. To the best of our knowledge, no previous cases of ectopic pregnancy localized to the mesorectum have been reported to date. Here, we present the case of a woman in her mid-30s with retroperitoneal ectopic pregnancy localized to the mesorectum. The condition was initially misdiagnosed as gastroenteritis due to atypical symptoms, which resulted in delayed treatment. This study aimed to improve the clinical recognition of mesorectal ectopic pregnancy among physicians.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 9","pages":"3000605251375215"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}