Journal of International Medical Research最新文献

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Effects of epidural dexmedetomidine on patient-controlled epidural analgesia after total knee arthroplasty: a single-center, prospective, double-blind, randomized controlled study.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311169
Seong Min Han, So Young Kwon, Jaesuk Kim, Jae Hyuk Kang, Jin Deok Joo
{"title":"Effects of epidural dexmedetomidine on patient-controlled epidural analgesia after total knee arthroplasty: a single-center, prospective, double-blind, randomized controlled study.","authors":"Seong Min Han, So Young Kwon, Jaesuk Kim, Jae Hyuk Kang, Jin Deok Joo","doi":"10.1177/03000605241311169","DOIUrl":"10.1177/03000605241311169","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of adding epidural dexmedetomidine to low-concentration patient-controlled epidural analgesia (PCEA) on pain control and side effects in total knee arthroplasty (TKA).</p><p><strong>Methods: </strong>In this double-blind study, American Society of Anesthesiologists I to II patients undergoing TKA were assigned to receive 0.125% bupivacaine + fentanyl 4 µg/mL (group R) or 0.1% bupivacaine + fentanyl 2 µg/mL with an epidural injection of dexmedetomidine 1 µg/kg (group D). The primary outcomes were the effectiveness of postoperative pain control as assessed by the numeric pain rating scale (NRS) and the incidence of side effects. Secondary outcomes included hemodynamic parameters (systolic and diastolic blood pressure, heart rate), motor block assessment, sensory block duration, analgesia duration, and the need for additional analgesia.</p><p><strong>Results: </strong>Both groups achieved similar pain control as indicated by NRS scores. However, group D experienced lower rates of urinary retention and pruritus, whereas sedation in the recovery room was greater in group D. Group R had significantly higher systolic pressure in the recovery room. group D exhibited significantly lower heart rates at 5 and 10 minutes.</p><p><strong>Conclusions: </strong>Low-concentration PCEA with epidural dexmedetomidine provides similar analgesia after TKA as high-concentration PCEA with fewer side effects.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311169"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery. 原发性闭角症手术中术前使用甘露醇对撕囊及减少术中并发症作用的前瞻性研究。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241310106
Zhiqiao Liang, Hongyan Li, Xianru Hou, Kangyi Yang, Kun Lv, Yao Ma, Ye Lu, Kuankuan Wu, Huijuan Wu
{"title":"Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery.","authors":"Zhiqiao Liang, Hongyan Li, Xianru Hou, Kangyi Yang, Kun Lv, Yao Ma, Ye Lu, Kuankuan Wu, Huijuan Wu","doi":"10.1177/03000605241310106","DOIUrl":"10.1177/03000605241310106","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of preoperative intravenous mannitol on the capsulorhexis process and intraoperative complications in patients with primary angle-closure glaucoma (PACG).</p><p><strong>Methods: </strong>In this prospective randomized controlled trial, 65 PACG eyes were randomized into the mannitol and control groups. The capsulorhexis duration, number of forceps grasps, need for viscoelastic re-injection, and intraoperative complications were recorded.</p><p><strong>Results: </strong>The mannitol group had a significantly shorter capsulorhexis duration and fewer forceps grasps of the capsule. All intraoperative complications (18.2%) occurred in the control group. The patients with intraoperative complications had significantly higher intraocular pressure and lower best-corrected visual acuity than those without complications after surgery. Multivariate analysis found that intravenous mannitol (odds ratio [OR] = -14.263; 95% confidence interval [CI] =-26.713 to -1.813) reduced the capsulorhexis duration, whereas zonulopathy (OR = 14.477, 95% CI = 2.622-26.331) prolonged the duration.</p><p><strong>Conclusion: </strong>Preoperative intravenous mannitol can reduce the risk of intraoperative complications and improve postoperative outcomes in patients with PACG. Factors including anterior chamber depth, incision location and method, and the zonule status significantly influence the capsulorhexis process.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241310106"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative infarction during coronary bypass surgery: an attempt to refine the diagnostic criteria using data from a retrospective case-control study.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241306866
Lars Niclauss, Liam-Kani Roulet, Piergiorgio Tozzi, Filip Dulguerov, Ziyad Gunga, Anna Nowacka, Matthias Kirsch
{"title":"Perioperative infarction during coronary bypass surgery: an attempt to refine the diagnostic criteria using data from a retrospective case-control study.","authors":"Lars Niclauss, Liam-Kani Roulet, Piergiorgio Tozzi, Filip Dulguerov, Ziyad Gunga, Anna Nowacka, Matthias Kirsch","doi":"10.1177/03000605241306866","DOIUrl":"10.1177/03000605241306866","url":null,"abstract":"<p><strong>Objective: </strong>The definition of coronary artery bypass graft (CABG)-associated myocardial infarction (MI) is controversial because the postoperative increases in cardiac enzyme activities are multifactorial in origin.</p><p><strong>Methods: </strong>We performed a retrospective case-control study of patients who experienced perioperative MI (cardiac enzyme release, electrocardiographic changes, dysfunction on echocardiography) and those without ischemia to identify risk factors and enzyme activity thresholds.</p><p><strong>Results: </strong>The estimated incidence of CABG-associated MI was 2.8%. The risk factors were a family history of cardiovascular disease (odds ratio (OR) 2.8), tobacco abuse (OR 3.8), recent MI (OR 3.6), and triple-vessel disease (OR 2.8). The MI group showed higher mortality (OR 2.3), prolonged intubation (OR 3.1), and a prolonged stay in intensive care (OR 4.3). The type 5 MI threshold (10 times the upper limit of the reference range (URL)) was exceeded in 88.4% (troponin I) and 96% (high-sensitivity troponin T; hs-cTnT) of patients without ischemia.</p><p><strong>Conclusions: </strong>The frequent exceeding of conventional MI-indicating thresholds in patients without ischemia indicates their low specificity. An enzyme activity increase alone is of limited diagnostic value for perioperative MI, which is associated with greater mortality. Finally, the use of a higher threshold for hs-cTnT (>45 × URL) may increase its specificity for graft failure.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241306866"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lumbar intervertebral disc calcification with massive herniation: a case report.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311772
Junxin Chen, Kangmao Huang, Song Dai, Yuanhang Chen, Wenbin Xu, Xiangqian Fang
{"title":"Lumbar intervertebral disc calcification with massive herniation: a case report.","authors":"Junxin Chen, Kangmao Huang, Song Dai, Yuanhang Chen, Wenbin Xu, Xiangqian Fang","doi":"10.1177/03000605241311772","DOIUrl":"10.1177/03000605241311772","url":null,"abstract":"<p><p>An 18-year-old female patient presented with a 1-month history of low back pain, which had worsened and was accompanied by radiating pain in the right lower limb for half a month. She was admitted to our hospital with computed tomography and magnetic resonance imaging findings suggesting calcification of the L3/4 disc and a large intraspinal mass at the L2-4 level. The patient's symptoms did not improve with conservative treatment, and her muscle strength rapidly declined. Therefore, a right-sided L3 laminotomy was performed for decompression. Intraoperatively, a cystic intraspinal mass with calcification was observed, and upon incision, a toothpaste-like substance flowed out. Pathological examination revealed fibrous tissue with glassy deposits and calcifications. Postoperatively, the patient's symptoms resolved completely, with no recurrence observed at the 2-month follow-up and complete resorption of the calcification at the L3/4 disc. Idiopathic intervertebral disc calcification with massive herniation poses a risk of permanent nerve function loss, and timely decompression is recommended to ensure a good prognosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311772"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ventricular fibrillation likely resulting from electrocautery and amiodarone: a rare clinical case report. 可能由电灼和胺碘酮引起的心室颤动:一个罕见的临床病例报告。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241310080
Jianwei Guo, Yan Cheng, Minmin Yi
{"title":"Ventricular fibrillation likely resulting from electrocautery and amiodarone: a rare clinical case report.","authors":"Jianwei Guo, Yan Cheng, Minmin Yi","doi":"10.1177/03000605241310080","DOIUrl":"10.1177/03000605241310080","url":null,"abstract":"<p><p>Monopolar electrocautery is usually a safe and effective technique used in laparoscopic cholecystectomy and bile duct surgery, but it may lead to adverse consequences, even ventricular fibrillation (VF). Amiodarone is an effective antiarrhythmic drug commonly used in practice to treat ventricular and atrial arrhythmias, but it may induce tachyarrhythmia or even VF. We report a case of VF occurring twice during cholecystectomy. The first VF was caused by low-frequency leakage current of the monopolar electrocautery. The second VF was due to amiodarone causing further prolongation of the corrected QT interval. By performing cardiopulmonary resuscitation and defibrillation, the patient recovered and was eventually discharged in good condition. In cholecystectomy surgery, especially when separating adhesive tissue from liver, caution should be exercised when using a monopolar electrotome, which is recommended to stop bleeding in the bipolar mode. After cardiopulmonary resuscitation, caution should be exercised when using amiodarone to prevent arrhythmia, even if prolongation of the corrected QT interval does not reach the diagnostic indicators of 470 ms for men and 480 ms for women. In addition, defibrillators should be in standby mode during the perioperative period.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241310080"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal mental disorders, psychotropic drugs, socioeconomic status, and offspring congenital anomalies. 母亲精神障碍、精神药物、社会经济地位与后代先天性异常。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241306902
Satu-Maarit Björkstedt, Hannu Koponen, Hannu Kautiainen, Mika Gissler M, P Pennanen, Johan G Eriksson, Merja K Laine
{"title":"Maternal mental disorders, psychotropic drugs, socioeconomic status, and offspring congenital anomalies.","authors":"Satu-Maarit Björkstedt, Hannu Koponen, Hannu Kautiainen, Mika Gissler M, P Pennanen, Johan G Eriksson, Merja K Laine","doi":"10.1177/03000605241306902","DOIUrl":"10.1177/03000605241306902","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether there is an association between maternal mental health, purchase of psychotropic drugs, socioeconomic status and major congenital anomalies in offspring.</p><p><strong>Methods: </strong>A register-based cohort study of 6189 Finnish primiparous women who had a singleton delivery between 2009 and 2015. Data on pregnancy and delivery outcomes, psychiatric diagnosis, prescription drug purchases and offspring congenital anomalies were obtained from Finnish national registers.</p><p><strong>Results: </strong>Severe depressive disorders were diagnosed in 2.0% of women and severe anxiety disorders in 1.1%. During pregnancy, 9.6% of women purchased psychotropic drugs. Of these women, 5.7% delivered an offspring with a major congenital anomaly. Women who purchased psychotropic drugs in pregnancy had an increased risk of delivering a child with major congenital anomalies compared with women who did not purchase psychotropic drugs. Multivariate regression analysis showed that purchase of benzodiazepines increased the risk of major congenital anomalies (odds ratio 2.11 [95% confidence interval 1.17 to 3.81]). Pregnant women purchasing psychotropic drugs more often lived alone and smoked, had higher body mass index, and had lower annual income and educational attainment than women not purchasing psychotropic drugs.</p><p><strong>Conclusions: </strong>Benzodiazepine use, but not socioeconomic status, may be associated with major congenital abnormalities in offspring.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241306902"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behçet's disease: recurrent ischemic stroke as an initial presentation - a case based review.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311446
Anwar Albasri, Wesam Gouda, Faisal Alsaqabi, Mahmoud M Magdy, Ashraf A Mostafa, Nehal El Ghobashy
{"title":"Behçet's disease: recurrent ischemic stroke as an initial presentation - a case based review.","authors":"Anwar Albasri, Wesam Gouda, Faisal Alsaqabi, Mahmoud M Magdy, Ashraf A Mostafa, Nehal El Ghobashy","doi":"10.1177/03000605241311446","DOIUrl":"10.1177/03000605241311446","url":null,"abstract":"<p><p>Behçet's disease (BD) is a rare systemic vasculitis that is characterized by recurrent oral and genital ulcers, uveitis, and skin lesions. Although neurological involvement is a known complication, ischemic stroke remains uncommon. Herein, we report a 37-year-old Kuwaiti woman who experienced recurrent ischemic stroke with no traditional risk factors. Imaging studies, including magnetic resonance imaging and angiography, confirmed the diagnosis of recurrent ischemic stroke and identified the underlying vasculitic changes. A detailed examination revealed a history of recurrent orogenital ulcers, leading to a diagnosis of BD. High-dose corticosteroids, azathioprine, and antiplatelet treatment were effectively used to manage her acute strokes and underlying vasculitis, thus preventing further thrombotic events. Our case report underscores the difficulties of diagnosing BD with ischemic stroke as the initial manifestation and emphasizes the importance of a multidisciplinary approach that involves rheumatologists, neurologists, and radiologists to create an effective treatment plan. Our findings also underscore the need for medical practitioners to be more knowledgeable about ischemic stroke in young patients without risk factors from endemic areas of BD, and to develop effective therapy plans. Our review of the English literature indicates that this is only the fifth report of stroke as the first presentation of BD.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311446"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of chronic complete uterine inversion in a postmenopausal woman: a case report and literature review. 绝经后妇女慢性完全性子宫内翻1例报告并文献复习。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311158
Jie Hu, Weili Yang, Fang Zhang, Chunhong Yan
{"title":"A rare case of chronic complete uterine inversion in a postmenopausal woman: a case report and literature review.","authors":"Jie Hu, Weili Yang, Fang Zhang, Chunhong Yan","doi":"10.1177/03000605241311158","DOIUrl":"10.1177/03000605241311158","url":null,"abstract":"<p><p>Uterine inversion is a rare condition that refers to the collapse of the fundus into the uterine cavity and occurs in puerperal and non-puerperal conditions. Non-puerperal uterine inversion is particularly infrequent. Diagnosing non-puerperal uterine inversion is often challenging because it resembles vaginal or cervical tumors and pelvic organ prolapse. Furthermore, this condition alters the anatomical structure of pelvic organs, thereby complicating diagnosis and treatment, and potentially leading to misdiagnosis with grave consequences. We report a case of a postmenopausal woman who presented with irregular vaginal bleeding and dysuria for 2 months. Preoperative enhanced pelvic magnetic resonance imaging suggested a benign tumor combined with uterine inversion, which was subsequently confirmed during surgery. A laparoscopic attempt to reposition the uterus failed, leading to successful repositioning via an abdominal incision and subsequent total abdominal hysterectomy with bilateral salpingo-oophorectomy. A histopathological examination showed a submucosal leiomyoma, which was smaller than that typically reported in other cases. We also conducted a review of previous cases to offer empirical guidance for the diagnosis and treatment of this rare condition.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311158"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paraneoplastic syndrome with intestinal pseudo-obstruction in a patient with small cell lung carcinoma: a case report and literature review. 小细胞肺癌伴假肠梗阻的副肿瘤综合征1例报告并文献复习。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241245868
Xiao-Jun Ren, Zhao-Hong Shi, Ying-Xia Cheng, Yun Luo
{"title":"Paraneoplastic syndrome with intestinal pseudo-obstruction in a patient with small cell lung carcinoma: a case report and literature review.","authors":"Xiao-Jun Ren, Zhao-Hong Shi, Ying-Xia Cheng, Yun Luo","doi":"10.1177/03000605241245868","DOIUrl":"10.1177/03000605241245868","url":null,"abstract":"<p><p>Paraneoplastic chronic intestinal pseudo-obstruction (CIPO) is a rare manifestation associated with small cell lung carcinoma and other malignancies. In this report, we present a challenging case involving a 60-year-old man with small cell lung carcinoma who developed symptoms of intestinal pseudo-obstruction, including abdominal distention, pain, and obstipation. Despite receiving extensive treatment with intravenous gamma globulin and glucocorticoids, the patient's symptoms did not improve, ultimately resulting in irreversible nervous system damage. Through a comprehensive literature review, we explore the underlying mechanisms of paraneoplastic CIPO and discuss its diagnostic and therapeutic approaches. We emphasize the significance of timely detection of related antibodies for early diagnosis and treatment of CIPO to improve patient outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241245868"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal plasma urocortin level as a biomarker of preterm birth: a prospective cohort study in Sulaimaniyah city in Iraq.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311438
Sallama Kamel Nasir
{"title":"Maternal plasma urocortin level as a biomarker of preterm birth: a prospective cohort study in Sulaimaniyah city in Iraq.","authors":"Sallama Kamel Nasir","doi":"10.1177/03000605241311438","DOIUrl":"10.1177/03000605241311438","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the value of the urocortin (UCN) level to predict preterm delivery in women with threatened preterm labour.</p><p><strong>Methods: </strong>This prospective cohort study included 96 women with a singleton pregnancy between 28 and 34 weeks of gestation who were admitted with threatened preterm labour. The participants were monitored until delivery. The UCN level was compared between those with preterm and with full-term deliveries.</p><p><strong>Results: </strong>The mean UCN level was higher for preterm deliveries (96 ± 24.34 pg/mL) than for full-term deliveries (62.62 ± 23.63 pg/mL). A UCN cutoff level of 92 pg/mL had 20% sensitivity, 100% specificity, 100% positive predictive value, and 10% negative predictive value. Thus, 17.7% of women had a UCN level ≥ 92 pg/mL, and all delivered preterm. Among the 82.3% of women who had a UCN level < 92 pg/mL, 88.6% delivered preterm, and 11.4% delivered at full term. Moreover, 88.2% of women who had a UCN level ≥ 92 pg/mL delivered within 7 days and only 11.8% delivered after 7 days. However, 58.2% of women with a UCN level < 92 pg/mL delivered within 7 days and 41.8% delivered after 7 days.</p><p><strong>Conclusion: </strong>A UCN cutoff level of ≥92 pg/mL predicts preterm delivery within 7 days of admission.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311438"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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