Journal of International Medical Research最新文献

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Correlation between sphenoid sinus pneumatization and sella turcica dimensions using computed tomography. 使用计算机断层扫描检查蝶窦积气与蝶窦尺寸之间的相关性。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241287021
Nuhad A Hassan, Mais Ah Mahdi, Noor S Irhyyim
{"title":"Correlation between sphenoid sinus pneumatization and sella turcica dimensions using computed tomography.","authors":"Nuhad A Hassan, Mais Ah Mahdi, Noor S Irhyyim","doi":"10.1177/03000605241287021","DOIUrl":"10.1177/03000605241287021","url":null,"abstract":"<p><strong>Objective: </strong>This study was performed to determine the dimensions of the sella turcica (ST) in relation to sex, age groups, and sphenoid sinus (SS) pneumatization patterns in a cohort of Iraqi individuals.</p><p><strong>Methods: </strong>This cross-sectional study analyzed computed tomography images of 99 individuals (53 men, 46 women) aged 24 to 59 years to measure ST dimensions, including length, width, height, depth, and surface area. SS pneumatization was classified by sex and age. We also examined the relationship between ST size and SS pneumatization patterns.</p><p><strong>Results: </strong>Women exhibited a significantly greater mean ST depth (9.37 mm) than men (8.19 mm). The ST diameter was significantly larger in the middle-aged group (13.1 mm) than in the young adult group (11.83 mm). The ST area showed a highly significant difference between sexes. The sellar pneumatization pattern was the most common, whereas the conchal pattern had the lowest prevalence. A significant correlation was observed between ST size and SS pneumatization.</p><p><strong>Conclusion: </strong>The ST depth and diameter showed statistically significant differences across sex and age groups, respectively. The variability in SS pneumatization patterns underscores the importance of considering pneumatization types during surgical planning to minimize the risk of iatrogenic injury and improve treatment outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241287021"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of rigid plate fixation for sternal closure in patients with a high risk of deep sternal wound infection. 对胸骨深部伤口感染风险较高的患者采用硬板固定进行胸骨闭合的效果。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241281915
Hiromasa Nakamura, Yujiro Miura, Keisuke Yoshida, Naoki Edo, Ren Saito, Kazumasa Orihashi
{"title":"Effectiveness of rigid plate fixation for sternal closure in patients with a high risk of deep sternal wound infection.","authors":"Hiromasa Nakamura, Yujiro Miura, Keisuke Yoshida, Naoki Edo, Ren Saito, Kazumasa Orihashi","doi":"10.1177/03000605241281915","DOIUrl":"10.1177/03000605241281915","url":null,"abstract":"<p><strong>Objective: </strong>Median sternotomy is a standard approach in cardiovascular surgery, and wire fixation is commonly used for sternal closure. However, postoperative intermittent stress on the sternum can lead to sternal breakdown, potentially resulting in deep sternal wound infection (DSWI). Sternal closure with rigid plate fixation was recently reported to be effective for preventing DSWI and promoting sternal healing. We investigated the effectiveness of a rigid plate fixation system in patients at a high risk of developing DSWI.</p><p><strong>Methods: </strong>This retrospective observational study evaluated the incidence of DSWI and the progression of postoperative sternal fusion observed on computed tomography. Forty-eight patients at a high risk of DSWI who underwent sternal closure with a rigid plate fixation system between 2020 and 2023 were assessed.</p><p><strong>Results: </strong>Among the 48 patients, 1 (2.1%) developed DSWI requiring surgical treatment. Sternal fusion improved over time, with significant progression observed during the follow-up period compared with the early postoperative period. Additionally, patients who did not show sternal fusion in the early postoperative period showed progressive fusion during follow-up.</p><p><strong>Conclusions: </strong>The rigid plate fixation system prevents sternal displacement and may be beneficial in preventing DSWI by maintaining and promoting sternal fusion in high-risk patients.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241281915"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the impact of transcranial electrical stimulation on post-stroke dysphagia: a systematic review and meta-analysis. 评估经颅电刺激对中风后吞咽困难的影响:系统回顾和荟萃分析。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241288843
Yanan Zhao, Zhicheng Zhang, Cuicui Wang, Hui Zhang, Ying Wang, Jing Bian
{"title":"Evaluating the impact of transcranial electrical stimulation on post-stroke dysphagia: a systematic review and meta-analysis.","authors":"Yanan Zhao, Zhicheng Zhang, Cuicui Wang, Hui Zhang, Ying Wang, Jing Bian","doi":"10.1177/03000605241288843","DOIUrl":"10.1177/03000605241288843","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a systematic review and meta-analysis to assess the impact of transcranial electrical stimulation (TES), proposed as a potential therapy for post-stroke dysphagia, on swallowing function in stroke survivors.</p><p><strong>Methods: </strong>The PubMed, Embase, Web of Science, and Cochrane Library databases were searched for relevant studies on TES for post-stroke dysphagia. Search results were reviewed following PRISMA guidelines, and the following data were extracted from included studies: study characteristics, demographics, and outcomes. Bias was assessed using the Cochrane tool. Heterogeneity and effect sizes were analysed using I<sup>2</sup> statistics and appropriate effects models. The study protocol was registered with PROSPERO (registration No. CRD42024578243).</p><p><strong>Results: </strong>Six randomized controlled trials met the inclusion criteria (I<sup>2</sup> = 0.0%). The meta-analysis indicated a significant improvement in dysphagia with TES (standardized mean difference [SMD] 0.43, 95% confidence interval [CI] 0.13, 0.73). Subgroup analysis suggested that low-intensity TES was effective (SMD 0.46, 95% CI 0.09, 0.82), whereas high-intensity TES showed no significant improvement (SMD 0.37, 95% CI -0.17, 0.91). No publication bias was detected.</p><p><strong>Conclusion: </strong>TES may improve swallowing in stroke patients, with potential benefits from low-intensity protocols.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241288843"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of the association between MBD4 Glu346Lys polymorphism and cancer risk. MBD4 Glu346Lys 多态性与癌症风险关系的元分析。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 Epub Date: 2019-12-31 DOI: 10.1177/0300060519895667
Jianguo Wang, Huaxiang Shen, Huijun Liang
{"title":"Meta-analysis of the association between <i>MBD4</i> Glu346Lys polymorphism and cancer risk.","authors":"Jianguo Wang, Huaxiang Shen, Huijun Liang","doi":"10.1177/0300060519895667","DOIUrl":"10.1177/0300060519895667","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to systematically evaluate the association between methyl-CpG binding domain 4, DNA glycosylase (<i>MBD4</i>) Glu346Lys polymorphism and cancer risk.</p><p><strong>Methods: </strong>A comprehensive document retrieval from the Chinese National Knowledge Infrastructure (CNKI), EMBASE, and PubMed databases was performed through 1 September 2019. The strength of the correlation was assessed using the pooled odds ratio (ORs) and 95% confidence interval (CIs).</p><p><strong>Results: </strong>Five relevant studies were retrieved following screening, including 1804 cases and 2193 controls. We found no association between <i>MBD4</i> Glu346Lys polymorphism and cancer risk under all genetic models. Nevertheless, a subgroup analysis based on country showed a strong association in the Chinese population. Under the recessive model, Chinese individuals with the Lys/Lys genotype had a higher risk of cancer (OR = 1.37, 95% CI = 1.11-1.70).</p><p><strong>Conclusion: </strong>Analysis of the <i>MBD4</i> Glu346Lys polymorphism in different populations will help to elucidate the pathogenesis of cancer. The polymorphism can be utilized as a biomarker for cancer susceptibility among Chinese people.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":" ","pages":"300060519895667"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37503496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of microRNAs on cardiovascular diseases and aging. 微小核糖核酸对心血管疾病和衰老的影响。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241279190
Md Sayed Ali Sheikh, Umme Salma
{"title":"Impact of microRNAs on cardiovascular diseases and aging.","authors":"Md Sayed Ali Sheikh, Umme Salma","doi":"10.1177/03000605241279190","DOIUrl":"10.1177/03000605241279190","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality for both men and women among all ethnicities worldwide. Although significant improvements in the management of CVD occurred in the 20th century, non-invasive, universal, early diagnostic biomarkers and newer therapeutic drugs are needed for clinical treatment by physicians. MicroRNAs (miRNAs) are a class of endogenous, non-coding, single-stranded, small RNA molecules that are critically controlled by all human biological processes. Moreover, dysregulated miRNA expression is directly involved in various CVDs, including stable coronary artery disease and acute coronary syndrome. Several miRNAs that are enriched in the plasma of CVD patients have potential as clinical biomarkers, and overexpression or inhibition of specific miRNAs has novel therapeutic significance in the management of CVD. Aging is a multifactorial physiological process that gradually deteriorates tissue and organ function and is considered a non-modifiable major risk factor for CVDs. Recently, several studies established that various miRNAs essentially regulate aging and aging-related disease processes. This narrative review briefly discusses the recently updated molecular involvement of miRNAs in CVDs, their possible diagnostic, prognostic, and therapeutic value, and their relationship to the aging process.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241279190"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral intravenous therapy infiltration and extravasation (PIVIE) risks in 11 006 paediatric surgery inpatients in China: a retrospective observational study. 中国 11 006 名儿科手术住院患者的外周静脉治疗浸润和外渗 (PIVIE) 风险:一项回顾性观察研究。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241283600
WenJiao Huang, Zheng Liu, Liwei Feng, Hong Zhu
{"title":"Peripheral intravenous therapy infiltration and extravasation (PIVIE) risks in 11 006 paediatric surgery inpatients in China: a retrospective observational study.","authors":"WenJiao Huang, Zheng Liu, Liwei Feng, Hong Zhu","doi":"10.1177/03000605241283600","DOIUrl":"10.1177/03000605241283600","url":null,"abstract":"<p><strong>Objective: </strong>To determine the risk factors associated with peripheral intravenous therapy infiltration and extravasation (PIVIE) in paediatric surgery inpatients.</p><p><strong>Methods: </strong>This retrospective observational study was conducted at a tertiary general hospital in Sichuan, China. Logistic regression was employed to identify independent risk factors predictive of PIVIE. Kaplan-Meier survival analysis was undertaken to determine the relationship between the occurrence of PIVIE and the duration of that event (survival time).</p><p><strong>Results: </strong>This study included 11 006 paediatric surgery inpatients and 19 771 peripheral intravenous catheters (PIVCs). The incidence of PIVIE was 16.93% (3347 of 19 771). The following were significant predictors of PIVIE: sex (odds ratio [OR] 0.834; 95% confidence interval [CI] 0.772, 0.900); age (OR 0.945; 95% CI, 0.934, 0.956); disease classification (OR 0.962, 95% CI 0.950, 0.976); puncture site (OR 1.061; 95% CI 1.044, 1.078); and indwelling time (OR 1.257; 95% CI 1.215, 1.300).</p><p><strong>Conclusions: </strong>Sex, age, type of disease, puncture site and indwelling time were risk factors for PIVIE. The puncture site should be effectively assessed and accurately selected. Informed judgements should be based on the child's sex, age and medical condition, so that the appropriate preventive measures to minimize the risk of PIVIE can be implemented.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241283600"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal meconium peritonitis after maternal hepatitis B: a case report and review of the literature. 母婴乙型肝炎后胎儿胎膜腹膜炎:病例报告和文献综述。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241283633
Li Zhang, Baorong Gao
{"title":"Fetal meconium peritonitis after maternal hepatitis B: a case report and review of the literature.","authors":"Li Zhang, Baorong Gao","doi":"10.1177/03000605241283633","DOIUrl":"10.1177/03000605241283633","url":null,"abstract":"<p><p>Maternal hepatitis virus has rarely been implicated in fetal meconium peritonitis (FMP), and its underlying mechanism is largely unknown. We describe a case of FMP presumably caused by maternal chronic hepatitis B virus (HBV). A 29-year-old primigravid woman was referred to our hospital at 35 weeks of gestation for the disappearance of fetal movements. The maternal prenatal history included HBV for more than 10 years. Her HBV DNA level was suppressed (<20 IU/mL) and she was taking oral tenofovir disoproxil fumarate (300 mg/day). At 21<sup>+5</sup> weeks, fetal ascites, echogenic bowel, and intra-abdominal calcifications were observed by abdominal ultrasound. These findings were confirmed by magnetic resonance imaging and were regarded as diagnostic for FMP. Cord blood and amniotic fluid were positive for hepatitis B e antigen and hepatitis B surface antigen. Ascites of the FMP was completely self-absorbed at 27<sup>+3</sup> weeks. At 35 weeks of gestation, fetal movements had vanished and male stillbirth was induced. A histopathological examination of the placenta showed meconium uptake by macrophages in the amniochorionic membranes. Our findings suggest that maternal HBV can cross the placenta and induce FMP. Close surveillance may allow an early diagnosis of FMP and prevent fetal mortality.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241283633"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional nerve blocks for peripheral neuropathy: a rare clinical case report. 区域神经阻滞治疗周围神经病变:罕见临床病例报告。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241282248
Jianwei Guo, Yan Cheng, Minmin Yi
{"title":"Regional nerve blocks for peripheral neuropathy: a rare clinical case report.","authors":"Jianwei Guo, Yan Cheng, Minmin Yi","doi":"10.1177/03000605241282248","DOIUrl":"https://doi.org/10.1177/03000605241282248","url":null,"abstract":"<p><p>Peripheral neuropathy is a common complication in patients with diabetes. However, the appropriateness of administering nerve block anesthesia to these patients remains uncertain. Key concerns include the potential for prolonged block duration, an increased risk of local anesthetic toxicity, and the possibility of further damaging already compromised peripheral nerves. We herein report a case involving a patient with diabetic peripheral neuropathy who underwent finger amputation under ultrasound-guided nerve block anesthesia and subsequently lost pain and temperature sensation in both hands 1 month later. For critically ill patients undergoing surgery, regional anesthesia, such as a nerve block, may be a more suitable option than general anesthesia. When performing nerve block procedures in patients with diabetes, using ultrasound guidance is recommended to ensure precise targeting and reduce the risk of complications. However, it remains unclear whether nerve block anesthesia exacerbates peripheral neuropathy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241282248"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between haemoglobin decline and long-term outcomes in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention. 接受经皮冠状动脉介入治疗的 ST 段抬高型心肌梗死 (STEMI) 患者血红蛋白下降与长期预后之间的关系。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 DOI: 10.1177/03000605241285241
Fatma Esin, Hüseyin Sefa Ince, Gökhun Akkan, Ugur Kocabas, Tuncay Kiris, Aykan Celik, Mustafa Karaca
{"title":"Association between haemoglobin decline and long-term outcomes in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention.","authors":"Fatma Esin, Hüseyin Sefa Ince, Gökhun Akkan, Ugur Kocabas, Tuncay Kiris, Aykan Celik, Mustafa Karaca","doi":"10.1177/03000605241285241","DOIUrl":"https://doi.org/10.1177/03000605241285241","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between in-hospital haemoglobin decline and long-term mortality and major adverse cardiovascular and cerebrovascular events (MACCE) among ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This retrospective analysis included adult patients who underwent primary PCI for STEMI. Haemoglobin levels were recorded at admission and 48-72 h later. Patients were divided into two groups based on the extent of haemoglobin decline: low (<3 g/dl or no decline) and high (≥3 g/dl). The primary endpoint was all-cause mortality at long-term follow-up. The secondary endpoint was MACCE.</p><p><strong>Results: </strong>Patients were divided into two groups: low group (<i>n</i> = 665) and high group (<i>n</i> = 111). The mortality rate was significantly higher in the high group (72 of 111 patients; 65%) than in the low group (185 of 655 patients; 28%). Propensity score matching confirmed this association, with higher mortality (41 of 79 patients [52%] versus 25 of 79 patients [32%]) and MACCE rates (56 of 79 patients [71%] versus 41 of 79 patients [52%]) in the high group compared with the low group, respectively.</p><p><strong>Conclusion: </strong>There was a significant association between in-hospital haemoglobin decline, even without visible bleeding, and increased long-term mortality and MACCE in STEMI patients undergoing primary PCI.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 10","pages":"3000605241285241"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population. PCSK9 E670G 多态性会增加中国汉族人群罹患冠心病的风险。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2024-10-01 Epub Date: 2019-12-16 DOI: 10.1177/0300060519892177
Zhang Lin, Shi Hong Wang, Da Yong Wei, Lu Min Wang, Zhong Wu Zhang
{"title":"<i>PCSK9</i> E670G polymorphism increases risk of coronary artery disease in a Chinese Han population.","authors":"Zhang Lin, Shi Hong Wang, Da Yong Wei, Lu Min Wang, Zhong Wu Zhang","doi":"10.1177/0300060519892177","DOIUrl":"10.1177/0300060519892177","url":null,"abstract":"<p><strong>Objective: </strong>Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world. The proprotein convertase subtilisin/kexin type 9 (<i>PCSK9</i>) E670G polymorphism has been reported to be associated with variability in levels of low density lipoprotein cholesterol, a risk factor for CAD. However, the relationship between <i>PCSK9</i> E670G and CAD is still not fully elucidated.</p><p><strong>Methods: </strong>A total of 225 patients and 189 control subjects were recruited in this study. DNA was extracted from peripheral blood samples and was genotyped by mass array method. In addition, we also conducted a meta-analysis of case-control studies to elucidate the relationship of CAD and polymorphism.</p><p><strong>Results: </strong>The GG genotype of <i>PCSK9</i> E670G was associated with a higher risk of CAD [odds ratio (OR) 2.994, 95% confidence interval (CI): 1.174-7.631], even adjusting for risk factors (OR 2.794, 95% CI: 1.215-7.460). Logistic regression analysis showed that the dominant genetic model increased the CAD risk (OR 2.313, 95% CI: 1.070-6.983) after adjusting the confounding factors. Meta-analysis results of 13 studies revealed that <i>PCSK9</i> E670G polymorphism was correlated with CAD risk under different genetic models.</p><p><strong>Conclusion: </strong>Our results demonstrated that <i>PCSK9</i> E670G genotype was associated with a high risk of CAD.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":" ","pages":"300060519892177"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37460100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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