Journal of International Medical Research最新文献_第10页

Suicide risks among caregivers of patients with depressive disorders. 抑郁症患者照顾者的自杀风险。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-07-01 DOI: 10.1177/03000605241266226

Chia-Chi Lin, Yu-Chi Huang, Yu Lee, Pao-Yen Lin, Nien-Mu Chiu, Chi-Fa Hung, Liang-Jen Wang

{"title":"Suicide risks among caregivers of patients with depressive disorders.","authors":"Chia-Chi Lin, Yu-Chi Huang, Yu Lee, Pao-Yen Lin, Nien-Mu Chiu, Chi-Fa Hung, Liang-Jen Wang","doi":"10.1177/03000605241266226","DOIUrl":"10.1177/03000605241266226","url":null,"abstract":"Objective: To investigate the suicide risk factors among caregivers of individuals with depression who may develop suicidal ideation due to the ongoing challenges of managing the patient's mood fluctuations.Methods: This cross-sectional study enrolled dyads of patients with depression and their caregivers from a medical centre. The assessment included a psychiatric diagnostic interview, the Hospital Anxiety and Depression Scale, the List of Threatening Experiences, Benefit Finding Scale, Numerical Pain Rating Scale, Stigma Subscale of the Explanatory Model Interview Catalogue, Big Five Inventory-10, the Family APGAR Index and the Suicide Assessment Scale. Univariate and multivariate regression analysis were used to explore the interrelationship between the mental health of patients and caregivers.Results: Among the 125 caregivers, 60.0% (n = 75) were females. The most common psychiatric diagnoses were depressive disorders (33 of 125; 26.4%), followed by anxiety disorders (21 of 125; 16.8%) and insomnia disorder (19 of 125; 15.2%). There was a significant association between the stressful life events of depressive patients and the suicide risk of their caregivers. The severity of anxiety and depression in caregivers was significantly associated with the suicide risk among the caregivers.Conclusion: A relationship may exist between the psychological well-being of patients with depression and their caregivers.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 trends across borders: Identifying correlations among countries. COVID-19 跨国趋势：确定国家之间的相关性。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-07-01 DOI: 10.1177/03000605241266233

Jihan Muhaidat, Aiman Albatayneh

{"title":"COVID-19 trends across borders: Identifying correlations among countries.","authors":"Jihan Muhaidat, Aiman Albatayneh","doi":"10.1177/03000605241266233","DOIUrl":"10.1177/03000605241266233","url":null,"abstract":"Objectives: To enhance the accuracy of forecasting future coronavirus disease 2019 (COVID-19) cases and trends by identifying and analyzing correlations between the daily case counts of different countries reported between January 2020 and January 2023, to uncover significant links in COVID-19 patterns between nations, allowing for real-time, precise predictions of disease spread based on observed trends in correlated countries.Methods: Daily COVID-19 cases for each country were tracked between January 2020 and January 2023 to identify correlations between nations. Current case data were obtained from reliable sources, such as Johns Hopkins University and the World Health Organization. Data were analyzed in Microsoft Excel using Pearson's correlation coefficient to assess the strength of connections.Results: Strong correlations (r > 0.80) were revealed between the daily reported COVID-19 case counts of numerous countries across various continents. Specifically, 62 nations showed significant correlations with at least one correlated (connected) country per nation. These correlations indicate a similarity in COVID-19 trends over the past 3 or more years.Conclusion: This study addresses the gap in country-specific correlations within COVID-19 forecasting methodologies. The proposed method offers essential real-time insights to aid effective government and organizational planning in response to the pandemic.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of cord blood-derived platelet-rich plasma in the treatment of diseases. 脐带血富血小板血浆在疾病治疗中的应用。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-07-01 DOI: 10.1177/03000605241263729

Yukuan Tang, Yongsheng Li, Hanwei Chen, Yuyang Huang, Chen Huang, Wei Wei

{"title":"Application of cord blood-derived platelet-rich plasma in the treatment of diseases.","authors":"Yukuan Tang, Yongsheng Li, Hanwei Chen, Yuyang Huang, Chen Huang, Wei Wei","doi":"10.1177/03000605241263729","DOIUrl":"10.1177/03000605241263729","url":null,"abstract":"Platelet-rich plasma (PRP), a blood product containing high concentrations of platelets, has been increasingly used for the treatment of a number of diseases because of its anti-inflammatory and regenerative properties. PRP is generally obtained from the patient's own peripheral blood when used in clinical applications, but allogeneic PRP extracted from umbilical cord blood has also attracted attention due to its unique advantages. The main purpose of this narrative review was to summarize the research and clinical application of cord blood-derived PRP (CB-PRP) in the treatment of diseases up to April 2024. This review also discusses the differences between CB-PRP and autologous PRP (A-PRP). A thorough search of PubMed® and Clinicaltrials.gov identified 13 articles and four clinical trials. To date, CB-PRP has been primarily studied in the fields of orthopaedics, dermatology, neurology, obstetrics/gynaecology and ophthalmology. This is likely to be because this research is relatively novel. Considering the differences between the characteristics of A-PRP and CB-PRP, it is thought that CB-PRP might hold more promise for broader applications in the future.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The improvement effect of exercise on rats with chronic stress-induced depression-like behavior: a discussion based on the kynurenine pathway. 运动对慢性压力诱导的抑郁样行为大鼠的改善作用：基于犬尿氨酸途径的讨论。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-07-01 DOI: 10.1177/03000605241261986

Lingling Zhao, Minqiang Du, Ruihong Zhang

{"title":"The improvement effect of exercise on rats with chronic stress-induced depression-like behavior: a discussion based on the kynurenine pathway.","authors":"Lingling Zhao, Minqiang Du, Ruihong Zhang","doi":"10.1177/03000605241261986","DOIUrl":"10.1177/03000605241261986","url":null,"abstract":"Objective: To observe the effects of 4 weeks of voluntary wheel running on depressive-like behavior in a rat chronic stress-induced depression model to explore the anti-depressive mechanism of exercise.Methods: In this observational study, 36 Sprague-Dawley rats were randomly divided into control, stress model, and stress exercise groups (12 rats/group). The control group received no intervention, and the stress model and stress exercise group rats underwent chronic mild unpredictable stress and isolation. The stress exercise group rats also underwent 4 weeks of voluntary wheel running. Behavioral changes and hippocampal protein and mRNA expression levels were detected.Results: Voluntary wheel running significantly increased horizontal and vertical movements, sucrose intake, and the sucrose preference percentage and reduced immobility time in the forced swimming test in depression model rats. The hippocampal tumor necrosis factor-α, interleukin (IL)-6, IL-1β, and quinolinic acid levels were significantly decreased, while the IL-4, IL-10, and kynurenic acid levels were significantly increased. Kynurenine-3-monooxygenase and 3-hydroxyanthranilate-3, 4-dioxygenase mRNA levels were downregulated, and kynurenine aminotransferase mRNA was upregulated.Conclusion: Voluntary wheel running improved depressive-like behavior in depression model rats. The mechanism may be related to a kynurenine pathway metabolite level imbalance, which has neurotoxic and neuroprotective effects, caused by long-term voluntary wheel running.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective study of the clinical manifestations and efficacy of immunotherapy for patients with acquired hemophilia A. 对获得性血友病 A 患者的临床表现和免疫疗法疗效的回顾性研究。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-07-01 DOI: 10.1177/03000605241266221

Fei Gao, Changhu Dong, Mingzhu Du, Zhenzhen Li, Yanping Song, Guang Li

{"title":"Retrospective study of the clinical manifestations and efficacy of immunotherapy for patients with acquired hemophilia A.","authors":"Fei Gao, Changhu Dong, Mingzhu Du, Zhenzhen Li, Yanping Song, Guang Li","doi":"10.1177/03000605241266221","DOIUrl":"10.1177/03000605241266221","url":null,"abstract":"Objective: Raising awareness of acquired hemophilia A (AHA) and early diagnosis is critical to reduce the associated mortality rate. We aimed to characterize acquired hemophilia in Chinese patients and evaluate the effectiveness of immunotherapy.Methods: The clinical characteristics, laboratory test data, therapeutic approaches, and outcomes of 20 patients with AHA who were admitted to Xi'an Central Hospital between January 2012 and December 2020 were retrospectively studied.Results: Nine of the patients (45%) were treated by single glucocorticoid administration; three (15%) with cyclophosphamide (CP) in combination with a glucocorticoid; four individuals (20%) received a combination therapy of rituximab with CP and glucocorticoid or rituximab with CP, vincristine, and a glucocorticoid; three (15%) by injection of human immunoglobulin in combination with a glucocorticoid; and one (5%) with CP alone. Six patients (30%) achieved total remission and 11 (55%) partial remission (PR), but three (15%) did not enter remission, indicating an objective response rate of 85%.Conclusion: Combination therapy with rituximab or intravenous human immunoglobulin achieves superior results in some patients with AHA. Immunosuppression and the administration of coagulation factors can rapidly control the disease and are efficacious, but >50% of patients only achieved PR. These findings suggest that the complete elimination of inhibitors requires prolonged immunosuppression therapy.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11295235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregabalin-induced rhabdomyolysis: a case series and literature analysis. 普瑞巴林诱发横纹肌溶解症：系列病例和文献分析。

IF 1.6 4区医学

Journal of International Medical Research Pub Date : 2024-06-01 DOI: 10.1177/03000605241257776

Wenjing Zhai, Hao Liu, Jinrui Li, Haili Xin

{"title":"Pregabalin-induced rhabdomyolysis: a case series and literature analysis.","authors":"Wenjing Zhai, Hao Liu, Jinrui Li, Haili Xin","doi":"10.1177/03000605241257776","DOIUrl":"10.1177/03000605241257776","url":null,"abstract":"Pregabalin is a prescription medicine that has recently been approved for individuals who suffer from fibromyalgia, neuropathic pain, anxiety disorder, or epilepsy. Pregabalin has the side effects of dizziness, sleepiness, and angioedema. Pregabalin-induced rhabdomyolysis has been rarely reported, with only four reports to date. We report two cases of rhabdomyolysis after pregabalin treatment. A man aged older than 90 years presented with exhaustion, muscle aches, and a high serum creatine kinase concentration after taking 75 mg of pregabalin on the first day of treatment. A woman in her 90s with long-term use of pregabalin presented with considerably elevated serum creatine kinase concentrations. Both patients had a long history of taking statins. Pregabalin therapy was stopped, high-volume intravenous fluids were administered, and serum electrolytes were frequently checked. Alkalinisation was performed with excellent outcomes. The Naranjo Adverse Drug Reaction scale and previous research suggest an association between pregabalin and rhabdomyolysis. Clinicians should be alert to the possibility of rhabdomyolysis occurring with the use of pregabalin, especially when taking statins.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11181883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retroperitoneal dermoid cyst complicated with uterine adenomyoma: a case report and literature review. 腹膜后真皮样囊肿并发子宫腺肌瘤：病例报告和文献综述。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-06-01 DOI: 10.1177/03000605241255810

Yanhua Zhang, Hailing Liu, Wenjing Hou, Hui Cheng, Feng Wang, Lingyan Zhang, Jianbo Zhou, Feng Han, Weipei Zhu

引用次数: 0

Procalcitonin and C-reactive protein as early predictors in patients at high risk of colorectal anastomotic leakage. 将降钙素原和 C 反应蛋白作为结肠直肠吻合口漏高危患者的早期预测指标。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-06-01 DOI: 10.1177/03000605241258160

Yilong Hu, Junjie Ren, Zhixin Lv, He Liu, Xiewu Qiu

{"title":"Procalcitonin and C-reactive protein as early predictors in patients at high risk of colorectal anastomotic leakage.","authors":"Yilong Hu, Junjie Ren, Zhixin Lv, He Liu, Xiewu Qiu","doi":"10.1177/03000605241258160","DOIUrl":"10.1177/03000605241258160","url":null,"abstract":"Objective: To assess the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) for anastomotic leakage (AL) following colorectal surgery.Methods: We retrospectively analyzed data for patients who underwent colorectal surgery at our hospital between November 2019 and December 2023. CRP and PCT were measured postoperatively to compare patients with/without AL, and changes were compared between low- and high-risk groups. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic accuracy of CRP and PCT to identify AL in high-risk patients.Results: Mean CRP was 142.53 mg/L and 189.57 mg/L in the low- and high-risk groups, respectively, on postoperative day (POD)3. On POD2, mean PCT was 2.75 ng/mL and 8.16 ng/mL in low- and high-risk patients, respectively; values on POD3 were 3.53 ng/mL and 14.86 ng/mL, respectively. The areas under the curve (AUC) for CRP and PCT on POD3 were 0.71 and 0.78, respectively (CRP cut-off: 235.64 mg/L; sensitivity: 96%; specificity: 89.42% vs PCT cut-off: 3.94 ng/mL; sensitivity: 86%; specificity: 93.56%; AUC: 0.78). The AUC, sensitivity, and specificity for the combined diagnostic ability of CRP and PCT on POD3 were 0.92, 90%, and 100%, respectively (cut-off: 0.44).Conclusions: Combining PCT and CRP on POD3 enhances the diagnostic accuracy for AL.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment and nursing care of a patient diagnosed with malignant hyperthermia after general anesthesia: a case report. 一名全身麻醉后被诊断为恶性高热的患者的治疗和护理：病例报告。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-06-01 DOI: 10.1177/03000605241261962

Li Tian, Hanfei Li, Xiufen Zhang, Linzi Liao, Juan Wu, Xiang Pei

{"title":"Treatment and nursing care of a patient diagnosed with malignant hyperthermia after general anesthesia: a case report.","authors":"Li Tian, Hanfei Li, Xiufen Zhang, Linzi Liao, Juan Wu, Xiang Pei","doi":"10.1177/03000605241261962","DOIUrl":"10.1177/03000605241261962","url":null,"abstract":"Malignant hyperthermia (MH), characterized by severe myoclonus, pyrexia, tachycardia, hypertension, elevated muscle enzymes, and hypercapnia, often occurs in patients with congenital deformities or genetic disorders. Although the reported incidence rate is as low as 1:5000 to 1:100,000, patients with MH exhibit rapid aggravation and an elevated mortality rate. Thus, MH is associated with substantial perioperative risk. Successful treatment of patients with MH largely depends on early diagnosis and timely effective treatment. This clinical report provides a detailed description of a patient with newly diagnosed MH who developed a rapid rise in body temperature, end-tidal carbon dioxide, and heart rate during maxillary osteotomy. After successful rescue, the patient recovered smoothly during the postoperative period, indicating the importance of intraoperative monitoring, early diagnosis, effective treatment, and postoperative monitoring. This case is expected to serve as a reference for future interventions and healthcare practices in managing other patients with MH.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term discontinuation of warfarin in a patient with HeartMate 3 left ventricular assist device without thromboembolic events. 一名使用 HeartMate 3 左心室辅助装置的患者长期停用华法林，未发生血栓栓塞事件。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2024-06-01 DOI: 10.1177/03000605241258474

Yoganiranjana Dharuman, Mirko Doss, Petar Risteski, Aron Frederik Popov

{"title":"Long-term discontinuation of warfarin in a patient with HeartMate 3 left ventricular assist device without thromboembolic events.","authors":"Yoganiranjana Dharuman, Mirko Doss, Petar Risteski, Aron Frederik Popov","doi":"10.1177/03000605241258474","DOIUrl":"10.1177/03000605241258474","url":null,"abstract":"The gold standard therapy for end-stage heart failure is cardiac transplantation. However, in the face of a donor shortage, a mechanical assist device such as the left ventricular assist device HeartMate 3 (Abbott Laboratories, Abbott Park, IL, USA) serves as bridging therapy to transplantation and/or destination therapy. Current guidelines recommend anticoagulation with a vitamin K antagonist in combination with low-dose aspirin. We herein report a challenging anticoagulation regimen in a patient with a HeartMate 3 in whom systemic anticoagulation with warfarin was not feasible for 4 years because of low compatibility and a rare X-factor deficiency. This is a rare hematological disorder, estimated to affect approximately 1 in every 500,000 to 1,000,000 people in the general population. The patient finally received a modified anticoagulation regimen involving the combination of rivaroxaban and clopidogrel without warfarin. Under this regimen, the patient remained free of thromboembolic complications for 4 years with in situ placement of the left ventricular assist device. This case illustrates that under specific circumstances, long-term absence of warfarin therapy is feasible in patients with a HeartMate 3.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0