Journal of International Medical Research最新文献

{"title":"CircDock6 drives metabolic dysfunction-associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation.","authors":"Hongpeng Lu, Xiaoyun Ding, Peifei Li","doi":"10.1177/03000605251362984","DOIUrl":"10.1177/03000605251362984","url":null,"abstract":"<p><p>ObjectiveCircular RNAs belong to a category of noncoding RNAs that feature a unique continuous, covalently bonded ring configuration. Recent research indicates that circular RNAs are essential for the development of metabolic dysfunction-associated steatotic liver disease. This study sought to examine the functional role and molecular mechanism of circDock6 in metabolic dysfunction-associated steatotic liver disease.MethodsQuantitative reverse transcription polymerase chain reaction was performed to determine <i>circDock6</i> expression patterns in liver tissues from high-fat diet- and standard diet-fed mice in vivo. Triglyceride detection, western blot analysis, and oil red O staining were performed to evaluate the regulatory effect of circDock6 on metabolic dysfunction-associated steatotic liver disease in vitro.Results<i>CircDock6</i> was found to be markedly overexpressed in high-fat diet liver tissues compared with that in standard diet tissues. Moreover, knockdown of <i>circDock6</i> expression lowered triglyceride content and lipid droplet formation. Mechanistically, circDock6 acted as a molecular sponge for mmu-let-7g-5p, which regulated insulin-like growth factor 1 receptor expression and contributed to the progression of metabolic dysfunction-associated steatotic liver disease. <i>CircDock6</i> knockdown suppressed metabolic dysfunction-associated steatotic liver disease progression by modulating insulin-like growth factor 1 receptor via mmu-let-7g-5p targeting.ConclusionOur study identified circDock6 as a novel regulator of metabolic dysfunction-associated steatotic liver disease pathogenesis through the mmu-let-7g-5p/insulin-like growth factor 1 receptor axis, indicating its potential as a therapeutic target for metabolic dysfunction-associated steatotic liver disease intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251362984"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of myositis-specific autoantibodies in the diagnosis of idiopathic inflammatory myopathy and tumor risk prediction.","authors":"Lili Shi, Rong Min, Yanyan Wu, Jiahui Liu, Xia Liu, Peichang Wang","doi":"10.1177/03000605251362969","DOIUrl":"10.1177/03000605251362969","url":null,"abstract":"<p><p>ObjectiveTo investigate the value of myositis-specific autoantibodies in the diagnosis of idiopathic inflammatory myopathy and tumor risk prediction in patients with clinically suspected idiopathic inflammatory myopathy.MethodsThis retrospective study analyzed the myositis-specific autoantibodies and clinical characteristics of 357 patients with clinically suspected idiopathic inflammatory myopathy. Statistical analyses were conducted to assess the associations between myositis-specific autoantibodies and clinical symptoms.ResultsAmong the 357 patients with suspected idiopathic inflammatory myopathy, the co-occurrence rate of anti-synthetase and anti-Ro52 was 52.63%. Univariate analysis demonstrated significantly higher diagnostic rates of idiopathic inflammatory myopathy in patients positive for anti-synthetase and anti-Ro52 than in those who were seronegative. Patients who tested positive for anti-signal recognition particle exhibited distinct serological profiles and diagnostic outcomes compared with those who tested negative. Significant associations were observed between myositis-specific autoantibodies and tumor biomarkers. Multivariate logistic regression analysis identified serum creatinine and anti-synthetase antibody positivity as independent diagnostic predictors of idiopathic inflammatory myopathy.DiscussionAnti-synthetase antibodies were independently associated with idiopathic inflammatory myopathy. Co-positivity for anti-synthetase and anti-Ro52 was closely related to the diagnosis of idiopathic inflammatory myopathy. Myositis antibodies were significantly correlated with tumor biomarkers, highlighting their potential utility in early cancer screening. Elevated serum creatinine was also independently associated with idiopathic inflammatory myopathy, exhibiting diagnostic significance.ConclusionMyositis-specific autoantibodies have potential clinical value for early tumor screening and the diagnosis of idiopathic inflammatory myopathy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251362969"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12322362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring optimal serum selenium range for heart failure prevention: A U-shaped association and mediation by hepatic steatosis in US adults.","authors":"Han Li, Wenhu Liu, Jingjie Xiong, Xuehua Wang, Qian Xu, Ni Xiong, Yanling Huang, Yan Wang, Jing Hu, Zhaohui Wang","doi":"10.1177/03000605251370320","DOIUrl":"https://doi.org/10.1177/03000605251370320","url":null,"abstract":"<p><p>ObjectiveThe relationship between serum selenium levels and heart failure risk remains unclear. This study aimed to investigate the potential nonlinear association between serum selenium level and heart failure risk and explore whether hepatic steatosis and dyslipidemia mediate this relationship.MethodsData from 6969 adults in the National Health and Nutrition Examination Survey 2017-2020 cohort were analyzed. Logistic regression, restricted cubic spline, and random forest models were used to assess associations between serum selenium level and heart failure risk. Mediation analysis was used to evaluate the indirect effects of hepatic steatosis and lipid parameters. Mendelian randomization was used to infer causality.ResultsA U-shaped association was identified between serum selenium level and heart failure risk (<i>P</i> for nonlinearity = 0.003), with the lowest risk observed at 150-160 µg/L. Both low and high selenium levels were associated with increased heart failure risk. Hepatic steatosis and lipid markers partially mediated this association. Mendelian randomization analysis suggested a potential causal effect of genetically predicted serum selenium level on heart failure risk.ConclusionThese findings highlight a nonlinear association between selenium exposure and heart failure and suggest possible metabolic pathways underlying this association. However, further research is needed before any clinical recommendations can be made.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251370320"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity.","authors":"Jian Liu, Junli Ding, Liang Chen, Shoupeng Shao, Jie Mei, Xuejing Yang","doi":"10.1177/03000605251365844","DOIUrl":"10.1177/03000605251365844","url":null,"abstract":"<p><p>ObjectiveTo investigate the functions and immunological implication of formin-like protein 1 in pancreatic cancer.MethodsA multitude of public datasets and an in-house cohort were used to assess the clinical relevance and the immunological relevance of formin-like protein 1 in pancreatic cancer. Subsequently, in vitro assays were conducted to evaluate the biological roles of formin-like protein 1 in pancreatic cancer and its effects on immunity.ResultsThe expression of formin-like protein 1 was elevated in pancreatic cancer tissues and linked to a poor prognosis in pancreatic cancer. In vitro assays showed that elevated expression of formin-like protein 1 promoted pancreatic cancer progression. Moreover, formin-like protein 1 was linked to an inflamed tumor microenvironment and mediated epithelial-mesenchymal transition and programmed cell death 1 ligand 1 expression in pancreatic cancer.ConclusionsFormin-like protein 1 is a biomarker of an inflamed tumor microenvironment and positively modulates epithelial-mesenchymal transition and programmed cell death 1 ligand 1 expression in pancreatic cancer, which could be utilized as a novel target for antitumor immunity for more in-depth studies.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251365844"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear correlation between white blood cell counts and the progression and prognosis of acute kidney injury.","authors":"Honghua Liu, Qiao Gu, Yuhe Zhao, Hai Wang, Feng Liu","doi":"10.1177/03000605251369843","DOIUrl":"https://doi.org/10.1177/03000605251369843","url":null,"abstract":"<p><p>IntroductionWhite blood cell count, a cost-effective blood test marker, is used extensively for the diagnosis and prognosis of diseases. Nevertheless, its association with the progression and prognosis of acute kidney injury remains unclear.MethodsA retrospective analysis was conducted using data from a multicenter randomized trial on an acute kidney injury early warning system. Univariate analysis, multivariate logistic regression, and smooth curve fitting were used to evaluate the association between the white blood cell count and the progression and prognosis of acute kidney injury.ResultsA total of 5471 patients were included in the study. White blood cell counts were significantly associated with 14-day acute kidney injury progression (adjusted odds ratio: 1.04, 95% confidence interval: 1.02-1.06, <i>P</i> < 0.01) and 14-day mortality (adjusted odds ratio: 1.06, 95% confidence interval: 1.04-1.09, <i>P</i> < 0.01). However, white blood cell counts were not associated with 14-day dialysis (adjusted odds ratio: 1.01, 95% confidence interval: 0.97-1.05, <i>P = </i>0.77). Further curve fitting analysis found a linear correlation between white blood cell counts and 14-day acute kidney injury progression and 14-day mortality.ConclusionWhite blood cell counts had a significant linear correlation with 14-day acute kidney injury progression and 14-day mortality, but not with 14-day dialysis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251369843"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swyer syndrome in a Syrian female: A rare case report.","authors":"Shaghaf Alhallak, Ammer Alabed, Abdalla Khabazeh, Kamal Alwannous","doi":"10.1177/03000605251367394","DOIUrl":"https://doi.org/10.1177/03000605251367394","url":null,"abstract":"<p><p>Swyer syndrome, a form of complete gonadal dysgenesis, is a rare genetic condition in which phenotypic females exhibit a 46,XY karyotype. A 15-year-old girl presented with underdeveloped secondary sexual characteristics and amenorrhea. Laboratory investigations revealed elevated follicle-stimulating hormone levels and low estradiol levels, while imaging identified a small uterus and gonads. Chromosomal analysis confirmed a 46,XY karyotype. The patient was treated with hormone replacement therapy, resulting in significant pubertal development, reaching Tanner stage 3 within 8 months. This case highlights the importance of early recognition, chromosomal analysis, and tailored management in Swyer syndrome. Multidisciplinary approaches based on hormonal therapy, fertility counseling, and psychological support are crucial to improving patient outcomes. As the first case report of Swyer syndrome in Syria, this study underscores the need for heightened clinical awareness of this rare condition and widens the differential diagnosis for primary amenorrhea.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251367394"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian hemangioma: A rare case report.","authors":"Min Guo, Sai-Tian Zeng, Xu-Ni Wu, Yin Wang, Cui-Fen Li","doi":"10.1177/03000605251366972","DOIUrl":"10.1177/03000605251366972","url":null,"abstract":"<p><p>Ovarian hemangioma is an extremely rare benign tumor in clinical practice. We report the case of a postmenopausal woman presenting with vaginal bleeding, in whom imaging revealed a right adnexal mass. Surgical excision of the adnexa was performed, and pathological examination confirmed a right ovarian hemangioma. Concurrent findings included endometrial polyps and cervical polyps.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251366972"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal associations between schizophrenia and other psychiatric disorders: A Mendelian randomization study.","authors":"Yin Zhou, Yuxiao Chen, Pengli Wang, Kejing Zhang, Yili Zhang","doi":"10.1177/03000605251369855","DOIUrl":"https://doi.org/10.1177/03000605251369855","url":null,"abstract":"<p><p>ObjectiveSchizophrenia is a globally prevalent complex neuropsychiatric disorder that is frequently comorbid with various psychiatric disorders, leading to poor prognoses for affected patients. However, the causal relationships between schizophrenia and these comorbid disorders remain unclear.MethodsWe utilized Mendelian randomization to investigate the causal effects of schizophrenia on eight psychiatric disorders, including alcohol use disorder, anorexia nervosa, anxiety disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, bipolar disorder, depression, and obsessive-compulsive disorder, using data from the Psychiatric Genomics Consortium and other extensive Genome-Wide Association Studies. We employed the inverse variance-weighted method as the primary analysis, complemented by Mendelian randomization-Egger, weighted median, Mendelian randomization-Presso, Steiger filtering, leave-one-out sensitivity analysis, and reverse Mendelian randomization to address potential biases and validate the directionality of the causal relationships.ResultsOur analysis revealed that a genetically predicted one-log unit increase in schizophrenia risk was associated with a 70.7% increase in the odds of bipolar disorder (odds ratio: 1.707, 95% confidence interval: 1.58-1.84). We also found strong evidence regarding a causal relationship of schizophrenia with autism spectrum disorders, showing a 17.4% higher odds (odds ratio: 1.174, 95% confidence interval: 1.11-1.24). Additionally, schizophrenia conferred a 14.5% elevated risk of alcohol use disorder (odds ratio: 1.145, 95% confidence interval: 1.09-1.21), while a statistically significant yet clinically marginal association was observed with depression (odds ratio: 1.004, 95% confidence interval: 1.003-1.006). No causal relationships were detected between schizophrenia and attention-deficit hyperactivity disorder, anorexia nervosa, anxiety disorders, or obsessive-compulsive disorder. Sensitivity analyses reinforced these findings, and reverse Mendelian randomization analyses provided no evidence of reverse causal impacts on schizophrenia from the disorders examined.ConclusionThese findings confirm schizophrenia as a significant genetic risk factor for bipolar disorder, autism spectrum disorders, and alcohol use disorder. Our findings enhance understanding of the interrelationships among psychiatric disorders and offer novel insights into the clinical diagnosis and management of psychiatric comorbidities.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251369855"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of microparticles in oxidative stress and inflammation in patients with vascular intimal hyperplasia.","authors":"Xu-Lan Wang, Wen-Qi Han, Kun Yang, Feng-Jun Chang, Wei Zhang, Zhe Li, Yu-Juan Yang","doi":"10.1177/03000605251364781","DOIUrl":"10.1177/03000605251364781","url":null,"abstract":"<p><p>ObjectivesIntimal hyperplasia, which is mainly caused by vascular damage during percutaneous coronary intervention, affects the prognosis of patients who undergo percutaneous coronary intervention. However, it remains unclear whether circulating microparticles, which are also affected by percutaneous coronary intervention, participate in intimal hyperplasia.MethodsIn this applied basic research (also identified as a cross-sectional study), microparticles were obtained from healthy participants (n = 20), patients with serious intimal hyperplasia (n = 33), and patients with mild intimal hyperplasia (n = 33) 1 year after percutaneous coronary intervention. After origins testing, the effects of microparticles on the proliferation and migration (crucial processes in intimal hyperplasia) of human coronary artery smooth muscle cells were determined. The expression levels of extracellular signal-related kinase (ERK), p38 mitogen-activated protein kinase (P38), and c-Jun N-terminal kinase (JNK) as well as the production of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule 1 (markers related to oxidative stress, inflammation, and cell differentiation signaling pathways) were also evaluated.ResultsAlthough the microparticle concentration was higher in patients with mild and serious intimal hyperplasia than in healthy participants, there were no differences in the microparticle concentration between patients with mild and serious intimal hyperplasia. Flow cytometry revealed that the concentration of both endothelial-derived microparticles and platelet-derived microparticles increased in mild and serious intimal hyperplasia. Microparticles derived from patients with mild intimal hyperplasia stimulated the proliferation and migration of human coronary artery smooth muscle cells (partially blocked by PD98059); increased the phosphorylation of ERK and P38, but not JNK; and enhanced the production of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule 1 (blocked by SB20358). All these effects were more pronounced in patients with serious intimal hyperplasia.ConclusionsThe effects of microparticles in patients with intimal hyperplasia may reveal a therapeutic target for intimal hyperplasia.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251364781"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of 28-day mortality in patients with sepsis based on a predictive model: A retrospective cohort study.","authors":"Yi Sun, Tingting Wang, Mengna Zhang, Shuchen Cao, Liwei Hua, Kun Zhang","doi":"10.1177/03000605251361104","DOIUrl":"10.1177/03000605251361104","url":null,"abstract":"<p><p>ObjectiveThis study aimed to develop and validate a nomogram model for predicting 28-day mortality in patients with sepsis in the intensive care unit.MethodsThe health care records of 613 patients with sepsis who were hospitalized at the Affiliated Hospital of Chengde Medical University from 2022 to 2024 were retrospectively reviewed. Patients were randomly divided into training and testing sets in a 7:3 ratio. The least absolute shrinkage and selection operator regression method was used to identify potential prognostic factors for sepsis, followed by multivariate logistic regression to construct a nomogram prediction model. The predictive performance of the developed model was evaluated via receiver operating characteristic curves, decision curve analysis, and calibration curves.ResultsThe predictive factors included the platelet distribution width to count ratio, mean platelet volume, N-terminal proB-type natriuretic peptide level, lactate level, respiratory tract infections, and diabetes. The area under the receiver operating characteristic curve for the nomogram model in the training set was 0.907, with sensitivity and specificity values of 0.846 and 0.831, respectively. The calibration curve demonstrated that the prediction results were consistent with the actual findings. Decision curve analysis revealed that the model showed robust performance in practical applications.ConclusionsPlatelet distribution width to count ratio, mean platelet volume, N-terminal proB-type natriuretic peptide level, lactate level, respiratory tract infection, and diabetes are closely associated with sepsis. A nomogram model based on these six variables demonstrates remarkable predictive performance and may assist clinicians in identifying high-risk patients and optimizing personalized therapy.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 8","pages":"3000605251361104"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}