Journal of International Medical Research最新文献

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Steatotic liver disease diagnosed in a 24-year-old woman with Rett syndrome: a case report. 24岁女性Rett综合征诊断为脂肪变性肝病1例报告
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241310158
Larissa Albino, Adil Adatia, Aducio Thiesen, Brendan Halloran, Victor Dong, Carlos Moctezuma-Velázquez
{"title":"Steatotic liver disease diagnosed in a 24-year-old woman with Rett syndrome: a case report.","authors":"Larissa Albino, Adil Adatia, Aducio Thiesen, Brendan Halloran, Victor Dong, Carlos Moctezuma-Velázquez","doi":"10.1177/03000605241310158","DOIUrl":"10.1177/03000605241310158","url":null,"abstract":"<p><p>Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the <i>MECP2</i> gene, potentially disrupting lipid metabolism and leading to dyslipidemia (DLD) and steatotic liver disease (SLD). Although SLD has been described in RTT mouse models, it remains undocumented in humans. We herein describe a 24-year-old woman with RTT who was evaluated for abnormal liver enzymes. Imaging revealed hepatic steatosis, and transient elastography showed a controlled attenuation parameter of 342 dB/m and stiffness of 7.1 kPa. Laboratory investigations excluded secondary causes, including insulin resistance, metabolic syndrome, alcohol use, and new medications. Her Homeostatic Model Assessment for Insulin Resistance score was 1.8, her hemoglobin A1c concentration was 4.8%, and her lipid profile showed elevated triglycerides and low-density lipoprotein, consistent with DLD. Liver biopsy confirmed SLD. This case supports the hypothesis that <i>MECP2</i> mutations in RTT disrupt lipid metabolism through a unique pathophysiologic mechanism, increasing the risk of DLD and SLD independently of traditional metabolic syndrome factors. It highlights the importance of early screening for liver disease in patients with RTT, despite their young age, to prevent complications. Additionally, it validates <i>MECP2</i>-null mouse models as reliable tools for investigating future therapeutic strategies in RTT.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241310158"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of culture-negative infective endocarditis following cataract surgery.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311778
Gayashani K Jayasinghe, Logeswaran Dinusha, Udara S Perera, Indrakumar Jegarajah
{"title":"A rare case of culture-negative infective endocarditis following cataract surgery.","authors":"Gayashani K Jayasinghe, Logeswaran Dinusha, Udara S Perera, Indrakumar Jegarajah","doi":"10.1177/03000605241311778","DOIUrl":"10.1177/03000605241311778","url":null,"abstract":"<p><p>A 70-year-old man developed intermittent fever with chills, severe anorexia, generalized weakness, and mild exertional difficulty in breathing following posterior chamber intraocular lens replacement surgery for a mature white cataract in the left eye. Laboratory tests revealed persistent negative blood cultures, normocytic and normochromic anemia, neutrophilia, and elevated inflammatory markers despite multiple courses of antibiotics. All other investigations conducted to identify the cause of prolonged fever, including transthoracic echocardiography, were negative. However, transesophageal echocardiography detected an aortic valve vegetation. The patient had no history of valvular disease or any predisposing condition for infective endocarditis. The bacteremia was strongly suspected to have resulted from cataract surgery, although no obvious signs of eye infection were observed during the postoperative period. The patient was treated with empirical antibiotics, including vancomycin and ceftriaxone, which led to significant improvement. Because infective endocarditis remains a significant public health concern with increasing incidence rates, we present this unusual case of culture-negative infective endocarditis following cataract surgery, highlighting the diagnostic and therapeutic challenges encountered.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311778"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High FGF18 expression levels predict poor prognosis in endometrial carcinoma patients and promote tumor growth and metastasis.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311402
Zheng-Yao Lei, Jian Wu, Bao-Hua Zhang, Wei Xiang, Min Wang, Bin-Bin Li, Ming-Cheng Dai
{"title":"High FGF18 expression levels predict poor prognosis in endometrial carcinoma patients and promote tumor growth and metastasis.","authors":"Zheng-Yao Lei, Jian Wu, Bao-Hua Zhang, Wei Xiang, Min Wang, Bin-Bin Li, Ming-Cheng Dai","doi":"10.1177/03000605241311402","DOIUrl":"10.1177/03000605241311402","url":null,"abstract":"<p><strong>Objective: </strong>To investigate if fibroblast growth factor 18 (FGF18) expression plays an important role in endometrial carcinoma (EC).</p><p><strong>Methods: </strong>The clinicopathological associations and prognostic value of FGF18 expression were retrospectively analyzed in 190 patients with EC. FGF18 expression was stably knocked down in EC cell lines. Changes in cell proliferation, migration, and invasion rates were examined via cell behavior experiments. Tumor growth was investigated using a xenograft mouse model. RNA sequencing (RNA-seq) was performed to identify differentially expressed genes (DEGs) in HEC-1-B cells after FGF18 knockdown, followed by pathway enrichment analysis of the DEGs.</p><p><strong>Results: </strong>High FGF18 expression levels were closely correlated with EC clinicopathological features, such as histological subtype, FIGO stage, depth of myometrial invasion, and tumor size. Moreover, EC patients with high FGF18 expression levels had poorer overall survival. FGF18 knockdown in EC cells revealed its role in promoting tumor cell proliferation, migration, and invasion <i>in vitro</i>, as well as tumor growth <i>in vivo</i>. RNA-seq of HEC-1-B cells revealed that the DEGs were enriched in signaling pathways related to cell proliferation and migration.</p><p><strong>Conclusions: </strong>Overexpression of FGF18 may serve as a prognostic biomarker for EC patients and is a potential therapeutic target for treating this disease.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311402"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robert's uterus treated with ultrasound-guided laparoscopy and hysteroscopy: a case report.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311167
Jiying Li, Hongping Yue, Hongwen Hu, Yin Li, Huanhuan Sheng, Chengxing Wu
{"title":"Robert's uterus treated with ultrasound-guided laparoscopy and hysteroscopy: a case report.","authors":"Jiying Li, Hongping Yue, Hongwen Hu, Yin Li, Huanhuan Sheng, Chengxing Wu","doi":"10.1177/03000605241311167","DOIUrl":"10.1177/03000605241311167","url":null,"abstract":"<p><p>We report the case of a woman in her early 30 s who was diagnosed with Robert's uterus. She had been experiencing progressive dysmenorrhea for a decade and sought treatment for infertility at our hospital. Preoperative ultrasound imaging resulted in a misdiagnosis of a complete uterine septum with an accompanying ovarian cyst. However, intraoperative ultrasound-guided laparoscopy and hysteroscopy confirmed the presence of an asymmetric mediastinal uterus with a blind cavity, consistent with Robert's uterus, along with endometriosis. We performed a combined hysteroscopy and laparoscopy to excise the septum and endometrial cyst in the uterine cavity, and we inserted a uterine cavity stent to prevent postoperative intrauterine adhesions. Subsequent evaluations confirmed the success of the surgical and postoperative treatment strategies. The findings in this case suggest that despite the risk of a misdiagnosis before surgery, accurate assessment and effective surgical intervention for Robert's uterus can be achieved by the combined application of hysteroscopy and laparoscopy, with guidance by ultrasound. Furthermore, our findings highlight the importance of addressing concurrent conditions in the management of Robert's uterus.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311167"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smith-Magenis syndrome with Dandy-Walker malformation in a 2-year-old girl: A case report. 2岁女童Smith-Magenis综合征伴Dandy-Walker畸形1例报告。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241310844
Wen-Tong Zhu, Lu-Xia Jiang, Yu-Mei Ma, Xiang-Yang Wu, Qi-Ming Zhao
{"title":"Smith-Magenis syndrome with Dandy-Walker malformation in a 2-year-old girl: A case report.","authors":"Wen-Tong Zhu, Lu-Xia Jiang, Yu-Mei Ma, Xiang-Yang Wu, Qi-Ming Zhao","doi":"10.1177/03000605241310844","DOIUrl":"10.1177/03000605241310844","url":null,"abstract":"<p><p>Smith-Magenis syndrome (SMS) and Dandy-Walker malformation (DWM) are uncommon genetic conditions with nonspecific clinical features, which makes reaching a definitive diagnosis challenging. We describe here, a 2-year-old girl who was diagnosed with SMS at the age of 12 months due to delayed growth and development. The child presented to hospital with acute heart failure and respiratory failure. During the treatment process, her response was limited, and her recovery was slow. A subsequent head computed tomography (CT) scan showed abnormalities consistent with the diagnosis of comorbid DWM. We believe that this is the first reported case of a patient with SMS combined with DWM. By reporting this case, we aim to offer clinicians valuable insights into these rare diseases and provide a framework for future clinical diagnosis and treatment.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241310844"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the role of age, admission systolic blood pressure, and neutrophil-to-lymphocyte ratio in predicting left ventricular hypertrophy among patients with primary hypertension. 探讨年龄、入院收缩压和中性粒细胞与淋巴细胞比值在原发性高血压患者左心室肥厚预测中的作用。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241310159
Xiaoyong Hu, Djandan Tadum Arthur Vithran, Zhaoying Yang, Ting Zou, Rui Tang, Hongjian Li
{"title":"Investigating the role of age, admission systolic blood pressure, and neutrophil-to-lymphocyte ratio in predicting left ventricular hypertrophy among patients with primary hypertension.","authors":"Xiaoyong Hu, Djandan Tadum Arthur Vithran, Zhaoying Yang, Ting Zou, Rui Tang, Hongjian Li","doi":"10.1177/03000605241310159","DOIUrl":"10.1177/03000605241310159","url":null,"abstract":"<p><strong>Objective: </strong>In patients with primary hypertension (PH), left ventricular hypertrophy (LVH) is a critical predictor of cardiovascular events. We aimed to identify clinical and laboratory predictors of LVH in patients with PH.</p><p><strong>Methods: </strong>This retrospective cohort study included 2321 patients with PH at the Fifth Affiliated Hospital of Xinjiang Medical University from December 2022 to January 2024. Patients were classified into LVH and non-LVH groups; LVH was defined as left ventricular mass index (LVMI) >115 g/m<sup>2</sup> for men and >95 g/m<sup>2</sup> for women. Univariate and multivariate logistic analysis were used to identify risk factors for LVH.</p><p><strong>Results: </strong>Univariate analysis revealed significant differences between the LVH and non-LVH groups in age, sex, smoking, systolic blood pressure (SBP), neutrophil-to-lymphocyte ratio (NLR), body mass index, serum creatinine (SCr), lymphocyte count, and hypertension duration. Multivariate analysis identified age, sex, SBP, SCr, and NLR as independent risk factors for LVH. A combined receiver operating characteristic (ROC) model had an area under the ROC curve of 0.711 (95% CI: 0.68-0.74), with 75.3% sensitivity and 59.2% specificity.</p><p><strong>Conclusion: </strong>Age, sex, SBP, SCr, and NLR were independent predictors for LVH in patients with PH. Our combined diagnostic model provides valuable insight for early LVH screening, aiding timely clinical intervention.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241310159"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of epidural dexmedetomidine on patient-controlled epidural analgesia after total knee arthroplasty: a single-center, prospective, double-blind, randomized controlled study.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311169
Seong Min Han, So Young Kwon, Jaesuk Kim, Jae Hyuk Kang, Jin Deok Joo
{"title":"Effects of epidural dexmedetomidine on patient-controlled epidural analgesia after total knee arthroplasty: a single-center, prospective, double-blind, randomized controlled study.","authors":"Seong Min Han, So Young Kwon, Jaesuk Kim, Jae Hyuk Kang, Jin Deok Joo","doi":"10.1177/03000605241311169","DOIUrl":"10.1177/03000605241311169","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of adding epidural dexmedetomidine to low-concentration patient-controlled epidural analgesia (PCEA) on pain control and side effects in total knee arthroplasty (TKA).</p><p><strong>Methods: </strong>In this double-blind study, American Society of Anesthesiologists I to II patients undergoing TKA were assigned to receive 0.125% bupivacaine + fentanyl 4 µg/mL (group R) or 0.1% bupivacaine + fentanyl 2 µg/mL with an epidural injection of dexmedetomidine 1 µg/kg (group D). The primary outcomes were the effectiveness of postoperative pain control as assessed by the numeric pain rating scale (NRS) and the incidence of side effects. Secondary outcomes included hemodynamic parameters (systolic and diastolic blood pressure, heart rate), motor block assessment, sensory block duration, analgesia duration, and the need for additional analgesia.</p><p><strong>Results: </strong>Both groups achieved similar pain control as indicated by NRS scores. However, group D experienced lower rates of urinary retention and pruritus, whereas sedation in the recovery room was greater in group D. Group R had significantly higher systolic pressure in the recovery room. group D exhibited significantly lower heart rates at 5 and 10 minutes.</p><p><strong>Conclusions: </strong>Low-concentration PCEA with epidural dexmedetomidine provides similar analgesia after TKA as high-concentration PCEA with fewer side effects.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311169"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery. 原发性闭角症手术中术前使用甘露醇对撕囊及减少术中并发症作用的前瞻性研究。
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241310106
Zhiqiao Liang, Hongyan Li, Xianru Hou, Kangyi Yang, Kun Lv, Yao Ma, Ye Lu, Kuankuan Wu, Huijuan Wu
{"title":"Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery.","authors":"Zhiqiao Liang, Hongyan Li, Xianru Hou, Kangyi Yang, Kun Lv, Yao Ma, Ye Lu, Kuankuan Wu, Huijuan Wu","doi":"10.1177/03000605241310106","DOIUrl":"10.1177/03000605241310106","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of preoperative intravenous mannitol on the capsulorhexis process and intraoperative complications in patients with primary angle-closure glaucoma (PACG).</p><p><strong>Methods: </strong>In this prospective randomized controlled trial, 65 PACG eyes were randomized into the mannitol and control groups. The capsulorhexis duration, number of forceps grasps, need for viscoelastic re-injection, and intraoperative complications were recorded.</p><p><strong>Results: </strong>The mannitol group had a significantly shorter capsulorhexis duration and fewer forceps grasps of the capsule. All intraoperative complications (18.2%) occurred in the control group. The patients with intraoperative complications had significantly higher intraocular pressure and lower best-corrected visual acuity than those without complications after surgery. Multivariate analysis found that intravenous mannitol (odds ratio [OR] = -14.263; 95% confidence interval [CI] =-26.713 to -1.813) reduced the capsulorhexis duration, whereas zonulopathy (OR = 14.477, 95% CI = 2.622-26.331) prolonged the duration.</p><p><strong>Conclusion: </strong>Preoperative intravenous mannitol can reduce the risk of intraoperative complications and improve postoperative outcomes in patients with PACG. Factors including anterior chamber depth, incision location and method, and the zonule status significantly influence the capsulorhexis process.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241310106"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative infarction during coronary bypass surgery: an attempt to refine the diagnostic criteria using data from a retrospective case-control study.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241306866
Lars Niclauss, Liam-Kani Roulet, Piergiorgio Tozzi, Filip Dulguerov, Ziyad Gunga, Anna Nowacka, Matthias Kirsch
{"title":"Perioperative infarction during coronary bypass surgery: an attempt to refine the diagnostic criteria using data from a retrospective case-control study.","authors":"Lars Niclauss, Liam-Kani Roulet, Piergiorgio Tozzi, Filip Dulguerov, Ziyad Gunga, Anna Nowacka, Matthias Kirsch","doi":"10.1177/03000605241306866","DOIUrl":"10.1177/03000605241306866","url":null,"abstract":"<p><strong>Objective: </strong>The definition of coronary artery bypass graft (CABG)-associated myocardial infarction (MI) is controversial because the postoperative increases in cardiac enzyme activities are multifactorial in origin.</p><p><strong>Methods: </strong>We performed a retrospective case-control study of patients who experienced perioperative MI (cardiac enzyme release, electrocardiographic changes, dysfunction on echocardiography) and those without ischemia to identify risk factors and enzyme activity thresholds.</p><p><strong>Results: </strong>The estimated incidence of CABG-associated MI was 2.8%. The risk factors were a family history of cardiovascular disease (odds ratio (OR) 2.8), tobacco abuse (OR 3.8), recent MI (OR 3.6), and triple-vessel disease (OR 2.8). The MI group showed higher mortality (OR 2.3), prolonged intubation (OR 3.1), and a prolonged stay in intensive care (OR 4.3). The type 5 MI threshold (10 times the upper limit of the reference range (URL)) was exceeded in 88.4% (troponin I) and 96% (high-sensitivity troponin T; hs-cTnT) of patients without ischemia.</p><p><strong>Conclusions: </strong>The frequent exceeding of conventional MI-indicating thresholds in patients without ischemia indicates their low specificity. An enzyme activity increase alone is of limited diagnostic value for perioperative MI, which is associated with greater mortality. Finally, the use of a higher threshold for hs-cTnT (>45 × URL) may increase its specificity for graft failure.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241306866"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lumbar intervertebral disc calcification with massive herniation: a case report.
IF 1.4 4区 医学
Journal of International Medical Research Pub Date : 2025-01-01 DOI: 10.1177/03000605241311772
Junxin Chen, Kangmao Huang, Song Dai, Yuanhang Chen, Wenbin Xu, Xiangqian Fang
{"title":"Lumbar intervertebral disc calcification with massive herniation: a case report.","authors":"Junxin Chen, Kangmao Huang, Song Dai, Yuanhang Chen, Wenbin Xu, Xiangqian Fang","doi":"10.1177/03000605241311772","DOIUrl":"10.1177/03000605241311772","url":null,"abstract":"<p><p>An 18-year-old female patient presented with a 1-month history of low back pain, which had worsened and was accompanied by radiating pain in the right lower limb for half a month. She was admitted to our hospital with computed tomography and magnetic resonance imaging findings suggesting calcification of the L3/4 disc and a large intraspinal mass at the L2-4 level. The patient's symptoms did not improve with conservative treatment, and her muscle strength rapidly declined. Therefore, a right-sided L3 laminotomy was performed for decompression. Intraoperatively, a cystic intraspinal mass with calcification was observed, and upon incision, a toothpaste-like substance flowed out. Pathological examination revealed fibrous tissue with glassy deposits and calcifications. Postoperatively, the patient's symptoms resolved completely, with no recurrence observed at the 2-month follow-up and complete resorption of the calcification at the L3/4 disc. Idiopathic intervertebral disc calcification with massive herniation poses a risk of permanent nerve function loss, and timely decompression is recommended to ensure a good prognosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 1","pages":"3000605241311772"},"PeriodicalIF":1.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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