Journal of International Medical Research最新文献_第8页

Kimura's disease sequentially involving multiple sites in the head and neck: A case report with a 13-year follow-up and literature review. 木村氏病累及头颈部多个部位：1例13年随访及文献回顾

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1177/03000605251337422

Rui-Si Li, Xiang-Zi Zhang, Yu-Hua Quan, Yun-Ze Xuan

{"title":"Kimura's disease sequentially involving multiple sites in the head and neck: A case report with a 13-year follow-up and literature review.","authors":"Rui-Si Li, Xiang-Zi Zhang, Yu-Hua Quan, Yun-Ze Xuan","doi":"10.1177/03000605251337422","DOIUrl":"10.1177/03000605251337422","url":null,"abstract":"Kimura's disease is a rare, chronic inflammatory condition with a high recurrence rate, primarily affecting young to middle-aged Asian males. It typically manifests as masses in the head and neck, accompanied with regional lymphadenopathy. This report describes the case of a 50-year-old man initially diagnosed with Kimura's disease 13 years ago, following surgical removal of a left submandibular mass. Subsequent recurrences involved the parotid and contralateral submandibular regions, requiring radiotherapy and intermittent oral prednisone therapy. After 6 years, he developed progressive proptosis and visual impairment, revealing multiple orbital masses bilaterally. A puncture examination of the left submandibular mass was indicative of Kimura's disease. Throughout the follow-up period, the eosinophil levels correlated with prednisone use. This case highlights the disease's capacity for multisite recurrence within the head and neck over an extended duration. The extensive orbital involvement without renal manifestations is a rare presentation. Long-term follow-up is crucial in Kimura's disease management, and oral prednisone can effectively control disease progression.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251337422"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and clinical value of EIF3CL in serous ovarian cancer. EIF3CL在浆液性卵巢癌中的表达及临床价值

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1177/03000605251340320

Tingting Li, Longyang Liu, Qudi Qiao, Zhongqiu Lin, Jianhuan Yuan, Zhaoyang Zeng, Jilong Yao

{"title":"Expression and clinical value of EIF3CL in serous ovarian cancer.","authors":"Tingting Li, Longyang Liu, Qudi Qiao, Zhongqiu Lin, Jianhuan Yuan, Zhaoyang Zeng, Jilong Yao","doi":"10.1177/03000605251340320","DOIUrl":"10.1177/03000605251340320","url":null,"abstract":"ObjectivesThis study aimed to explore the expression of eukaryotic translation initiation factor 3 subunit C-like in serous ovarian cancer samples (both paraffin-embedded and fresh samples) and evaluate its clinical value in patients with serous ovarian cancer.MethodsTwenty-five fresh serous ovarian cancer tissues and their paired paratumor tissues were subjected to reverse transcription-quantitative polymerase chain reaction assay to detect eukaryotic translation initiation factor 3 subunit C-like messenger RNA expression. In addition, 135 paraffin-embedded serous ovarian cancer samples and 36 paratumor samples were assessed for eukaryotic translation initiation factor 3 subunit C-like protein expression using immunohistochemistry.ResultsBoth protein and messenger RNA expression levels of eukaryotic translation initiation factor 3 subunit C-like were higher in serous ovarian cancer samples than in paratumor samples, and its high expression was associated with poor overall survival in patients with serous ovarian cancer. In addition, multivariate Cox regression analysis showed that high expression of eukaryotic translation initiation factor 3 subunit C-like was an independent poor prognostic factor for patients with serous ovarian cancer.ConclusionsEukaryotic translation initiation factor 3 subunit C-like is upregulated in serous ovarian cancer samples, and it may be recommended as a useful poor prognostic biomarker in patients with serous ovarian cancer.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340320"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An optimized anthropometric index-a body shape index-cm-demonstrates superior performance in cardiovascular risk stratification. 优化的人体测量指数-体型指数-cm-在心血管风险分层中表现优异。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-24 DOI: 10.1177/03000605251343018

Jiayu Tian, Xuejie Wang, Xiaoqin Wen, Bo Gao

{"title":"An optimized anthropometric index-a body shape index-cm-demonstrates superior performance in cardiovascular risk stratification.","authors":"Jiayu Tian, Xuejie Wang, Xiaoqin Wen, Bo Gao","doi":"10.1177/03000605251343018","DOIUrl":"10.1177/03000605251343018","url":null,"abstract":"ObjectiveA body shape index is a novel indicator for assessing central obesity, but its relationship with cardiovascular disease and mortality remains unclear. This study aimed to assess whether a body shape index-cm, a refined version of a body shape index, improves cardiovascular risk stratification.MethodsUsing data from the National Health and Nutrition Examination Survey from 1999 to 2018, along with follow-up mortality data until 2019, we conducted an observational study to evaluate the performance of a body shape index-cm in identifying cardiovascular disease and predicting mortality. We compared a body shape index-cm with traditional anthropometric indices by employing receiver operating characteristic curve analysis, Cox proportional hazards regression, restricted cubic spline, and Kaplan-Meier survival analysis.ResultsAmong 47,668 participants, a body shape index-cm emerged as a superior screening tool for cardiovascular diseases, achieving an area under the curve of 0.701, surpassing those of waist-to-height ratio (0.631), waist circumference (0.624), and body mass index (0.556). A body shape index-cm showed the highest accuracy in identifying coronary heart disease (area under the curve: 0.728). A linear relationship was observed between a body shape index-cm and cardiovascular mortality risk, with each standard deviation increase in a body shape index-cm associated with a 20% increase in mortality risk.ConclusionsA body shape index-cm outperforms traditional measures in identifying cardiovascular disease and shows a linear correlation with cardiovascular mortality.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251343018"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune manifestations and direct-acting antiviral drugs in Egyptian patients with hepatitis C virus infection: A cohort study. 埃及丙型肝炎病毒感染患者的自身免疫表现和直接作用抗病毒药物：一项队列研究

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-20 DOI: 10.1177/03000605251339135

Hesham I Elmakhzangy, Mai A Rabie, Dina Mr Bahgat, Doaa Hs Attia, Ahmed Et Elsayed, Reem Hamdy A Mohammed

{"title":"Autoimmune manifestations and direct-acting antiviral drugs in Egyptian patients with hepatitis C virus infection: A cohort study.","authors":"Hesham I Elmakhzangy, Mai A Rabie, Dina Mr Bahgat, Doaa Hs Attia, Ahmed Et Elsayed, Reem Hamdy A Mohammed","doi":"10.1177/03000605251339135","DOIUrl":"10.1177/03000605251339135","url":null,"abstract":"ObjectivesTo investigate the clinical and serological features of autoimmunity with chronic hepatitis C virus infection before and after direct-acting antiviral therapy and assess their relation to treatment response.MethodsA prospective cohort study was performed in adult patients aged ≥18 years who had chronic hepatitis C virus infection, as confirmed by polymerase chain reaction, and were eligible for direct-acting antiviral therapy. Patients with rheumatological disease prior to the onset of hepatitis C virus infection, decompensated cirrhosis, or hepatocellular carcinoma were excluded. All patients were treated with sofosbuvir (400 mg once daily) plus daclatasvir (60 mg once daily) for 3 months. Patients were assessed before and 12 weeks after treatment.ResultsNinety patients completed the follow-up (66.7% females, 33.3% males, mean age: 49.2 ± 12.3 years); 85.55% of them had immune-mediated manifestations prior to direct-acting antiviral therapy. In patients with sustained virologic response, autoimmune manifestations persisted in 66 of the 71 (92.9%) patients with an observable rise in posttreatment erythrocyte sedimentation rate and C-reactive protein level (p > 0.01). The predictors of persistence of autoimmune manifestation were age ≥49 years (p = 0.009), female sex (p = 0.026), and tobacco use (p = 0.043).ConclusionDirect-acting antiviral drugs were not associated with a significant short-term change in the prevalence of autoimmune manifestations in patients who had hepatitis C virus infection with sustained virologic response.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251339135"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronavirus disease 2019-associated liver injury in pregnancy: A case report. 2019冠状病毒病相关妊娠期肝损伤1例报告

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-28 DOI: 10.1177/03000605251344150

Nan Yu, Yi-Yao Huang, Ling Feng, Qian Liu

{"title":"Coronavirus disease 2019-associated liver injury in pregnancy: A case report.","authors":"Nan Yu, Yi-Yao Huang, Ling Feng, Qian Liu","doi":"10.1177/03000605251344150","DOIUrl":"10.1177/03000605251344150","url":null,"abstract":"Liver injury is an increasingly recognized extrapulmonary manifestation of coronavirus disease 2019 (COVID-19), particularly during pregnancy due to overlapping physiological and pathological changes. A 26-year-old primigravida at 24+4 weeks of gestation presented with fever, chills, weakness, and sore throat, who was later confirmed to be severe acute respiratory syndrome coronavirus 2-positive. Laboratory tests revealed lymphopenia, elevated liver enzymes, low platelet count, increased D-dimer level, high total bilirubin level, and elevated lactate dehydrogenase levels. After thorough evaluation, these findings were attributed to COVID-19-associated liver injury. The patient was provided with supportive care and symptomatic treatment, resulting in gradual normalization of liver function. She was discharged at 26 weeks of gestation in stable condition. This case highlights the importance of considering COVID-19-associated liver injury in pregnant patients presenting with hepatic dysfunction, where prompt recognition and conservative management can help achieve favorable maternal outcomes.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251344150"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Removal of a trapped epidural catheter via spinal computed tomography reconstruction and optimal position simulation of the spinal model: A case report. 通过脊柱计算机断层重建和脊柱模型的最佳位置模拟去除困住的硬膜外导管：1例报告。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-13 DOI: 10.1177/03000605251340316

Yang Liu, Jin Yang, Xun Zhu, Jingjing Wu, Qi Hu, Ai Yan

{"title":"Removal of a trapped epidural catheter via spinal computed tomography reconstruction and optimal position simulation of the spinal model: A case report.","authors":"Yang Liu, Jin Yang, Xun Zhu, Jingjing Wu, Qi Hu, Ai Yan","doi":"10.1177/03000605251340316","DOIUrl":"10.1177/03000605251340316","url":null,"abstract":"Continuous epidural anesthesia is a classic anesthesia method that is widely used in abdominal surgery, labor analgesia, and postoperative analgesia. A long-term analgesic effect is achieved by continuously injecting local anesthetics into the epidural space through an epidural catheter. However, the insertion of epidural catheters is associated with various complications, such as total spinal anesthesia, nerve damage, bleeding, infection, and catheter distortion with difficult catheter removal. We present the case of a parturient woman who underwent vaginal delivery under epidural analgesia. However, after delivery, the epidural catheter could not be pulled out. Spinal computed tomography and three-dimensional reconstruction revealed that the catheter was coiled but not knotted in the spinal facet joints. Using optimal position simulation, we successfully pulled out the epidural catheter. This case demonstrates that spinal computed tomography reconstruction with optimal position simulation may be the most effective noninvasive method for successfully removing a trapped epidural catheter.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251340316"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrocardiographic features and ablation outcomes of near-Hisian idiopathic ventricular arrhythmias: Insights from a single-center study in Vietnam. 近希斯特发性室性心律失常的心电图特征和消融结果：来自越南单中心研究的见解。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI: 10.1177/03000605251342665

Ba Van Vu, Kien Trung Hoang, Thinh Duc Do, Hung Manh Nguyen, Linh Thi Hai Ngo, Long Hoang Vo, Dung Tien Le, Nguyen Thao Phan, Huu Cong Nguyen

{"title":"Electrocardiographic features and ablation outcomes of near-Hisian idiopathic ventricular arrhythmias: Insights from a single-center study in Vietnam.","authors":"Ba Van Vu, Kien Trung Hoang, Thinh Duc Do, Hung Manh Nguyen, Linh Thi Hai Ngo, Long Hoang Vo, Dung Tien Le, Nguyen Thao Phan, Huu Cong Nguyen","doi":"10.1177/03000605251342665","DOIUrl":"10.1177/03000605251342665","url":null,"abstract":"ObjectiveTo compare the clinical characteristics, electrocardiographic characteristics, and outcomes of radiofrequency catheter ablation in patients with idiopathic right ventricular outflow tract ventricular arrhythmias originating near the Hisian bundle region versus other right ventricular outflow tract regions.MethodsA single-center study analyzed 126 patients undergoing radiofrequency catheter ablation for right ventricular outflow tract ventricular arrhythmias from May 2020 to October 2022. Patients were classified into the near-Hisian group (n = 10) and the right ventricular outflow tract group (n = 116) based on the arrhythmia origin. Clinical, electrocardiographic, and procedural characteristics as well as ablation outcomes were compared.ResultsThe near-Hisian group had narrower QRS duration (132.3 ± 24.1 vs. 146.1 ± 28.3 ms), 100% positive QRS in lead I, smaller R-wave ratio in leads III/II (0.65 ± 0.20 vs. 0.97 ± 0.31), smaller Q-wave ratio in leads aVL/aVR (0.31 ± 0.29 vs. 1.03 ± 0.37), and larger R/S ratio in lead V2 (18.8 ± 10.9 vs. 12.0 ± 6.7) (all p < 0.05). Procedural metrics, acute success (90%), and long-term success (80%) were comparable between the two groups, with no major complications reported.ConclusionsRight ventricular outflow tract ventricular arrhythmias near the Hisian bundle region have distinct electrocardiographic features. Radiofrequency catheter ablation is safe and effective, emphasizing the need for precise electrocardiogram interpretation and meticulous procedural planning.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251342665"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical decision-making in adult patients with epilepsy related to germline mutations: A single-center study. 与种系突变相关的成年癫痫患者的手术决策：一项单中心研究

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-24 DOI: 10.1177/03000605251342517

Irina Podkorytova, Sasha Alick Lindstrom, Kan Ding, Ghazala Perven, Ryan Hays

{"title":"Surgical decision-making in adult patients with epilepsy related to germline mutations: A single-center study.","authors":"Irina Podkorytova, Sasha Alick Lindstrom, Kan Ding, Ghazala Perven, Ryan Hays","doi":"10.1177/03000605251342517","DOIUrl":"10.1177/03000605251342517","url":null,"abstract":"ObjectivesGenetic testing is not routinely performed during presurgical evaluation of adult patients with epilepsy.MethodsIn this retrospective observational study, we analyzed the diagnostic yield of an epilepsy multigene panel and patient characteristics in adult epilepsy surgery candidates from 2014 to 2024. We compared data collected from patients with GTPase-activating protein activity toward Rags 1 (GATOR1) and non-GATOR1 pathway mutations.ResultsIn total, 31 of the 236 (13%) patients tested positive for monogenic epilepsy disorders. The epilepsy multigene panel diagnostic yield was 12% (28 of the 233 patients). Overall, 9 of the 31 patients had GATOR1 pathway mutations. Moreover, 15 of the 31 patients underwent invasive electroencephalography evaluations, with 6 exhibiting GATOR1 and 9 exhibiting non-GATOR1 pathway mutations. In the GATOR1 mutations group, three of the six (50%) patients had focal ictal onset. In the non-GATOR1 mutations group, two of the nine (22%) patients had focal ictal onset. Overall, 8 of the 31 patients underwent resection or laser ablation, with 4 exhibiting GATOR1 and 4 exhibiting non-GATOR1 pathway mutations. In the GATOR1 mutations group, four of the nine (44.4%) patients underwent resection or laser ablation, and all had favorable outcomes (Engel I-II). In the non-GATOR1 mutations group, 4 of the 22 (18.2%) patients underwent resection. One patient had a favorable outcome (Engel I).ConclusionsGenetic testing may be helpful for selection of epilepsy surgery candidates and for counseling regarding expected epilepsy surgery outcome. These findings may be valuable for large multicenter studies with the goal to streamline the surgical journey of epilepsy patients with germline mutations.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251342517"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and clinicopathological features of human epidermal growth factor receptor-2-low breast cancers: A single-center experience. 人类表皮生长因子受体-2低乳腺癌的患病率和临床病理特征：单中心研究

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-05-01 Epub Date: 2025-05-24 DOI: 10.1177/03000605251342508

Ilkay Cinar

{"title":"Prevalence and clinicopathological features of human epidermal growth factor receptor-2-low breast cancers: A single-center experience.","authors":"Ilkay Cinar","doi":"10.1177/03000605251342508","DOIUrl":"10.1177/03000605251342508","url":null,"abstract":"ObjectiveHuman epidermal growth factor receptor-2-low breast cancer, characterized by low-level human epidermal growth factor receptor-2 expression and immunohistochemistry score 1+ or immunohistochemistry score 2+ without amplification, has been proposed as a distinct subgroup. This study investigated the prevalence and clinicopathological characteristics of human epidermal growth factor receptor-2-low breast cancers.MethodsA retrospective observational cohort study was conducted on patients diagnosed with invasive breast carcinoma between 2021 and 2023 at a single tertiary center. Data on histological type, tumor grade, human epidermal growth factor receptor-2 status, and Ki-67 proliferation index were collected.ResultsAmong the 181 patients who were included, 54.7% were classified as human epidermal growth factor receptor-2-low, 27.6% as human epidermal growth factor receptor-2-negative, and 17.7% as human epidermal growth factor receptor-2-positive. Human epidermal growth factor receptor-2-low tumors were predominantly those classified into grade 2 (69.7%). The mean age of patients with human epidermal growth factor receptor-2-low tumors was 60 years. The Ki-67 index was significantly lower in human epidermal growth factor receptor-2-low tumors than in human epidermal growth factor receptor-2-positive and human epidermal growth factor receptor-2-negative groups (p = 0.001). No significant differences were observed in the rates of axillary lymph node metastasis among the groups (p = 0.13).ConclusionHuman epidermal growth factor receptor-2-low breast cancers constitute a significant proportion of breast cancer cases and are associated with distinct clinicopathological features, including high estrogen reception positivity and lower Ki-67 proliferation rates.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251342508"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of unexpected thyroid storm in postpartum. 产后意外甲状腺风暴1例。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI: 10.1177/03000605251335803

Yuxin Qin, Ying Wu, Ling Yu, Dandan Hu, Huanhuan Zang, Xiangguo Cong, Qiong Shen, Lei Chen, Xinxin Chen

{"title":"A case of unexpected thyroid storm in postpartum.","authors":"Yuxin Qin, Ying Wu, Ling Yu, Dandan Hu, Huanhuan Zang, Xiangguo Cong, Qiong Shen, Lei Chen, Xinxin Chen","doi":"10.1177/03000605251335803","DOIUrl":"https://doi.org/10.1177/03000605251335803","url":null,"abstract":"Thyroid storm is a rare and serious endocrine crisis during the perinatal period and typically occurs in patients with Graves' disease. We present the case of a postpartum woman without prior history of thyroid disease who presented with vomiting, fever, irregular abdominal pain, and a diagnosis of intrauterine death. Despite comprehensive treatment, she showed persistent tachycardia, fever, and multi-organ failure. Diagnostic assessment revealed elevated thyroid hormone levels, and she was diagnosed with thyroid storm based on the scoring system of Burch-Wartofsky and the Japanese Thyroid Association diagnostic criteria. Treatment included plasmapheresis, β-blockers, iodine solutions, antithyroid drugs, and corticosteroids. Following successful mitigation of thyroid storm, she developed hypothyroidism and was treated with levothyroxine. For patients with no history of thyroid disease or negative thyroid autoantibodies, especially postpartum women, presenting unexplained symptoms such as tachycardia, fever, diarrhea, sweating, and altered consciousness, the possibility of thyroid storm should be considered.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251335803"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0