Journal of International Medical Research最新文献

{"title":"Effect of repeated intra-articular administration of collagen as a treatment for knee osteoarthritis: a case report.","authors":"Yong In, Saad Mohammed Alshammari, Man Soo Kim","doi":"10.1177/03000605241291735","DOIUrl":"10.1177/03000605241291735","url":null,"abstract":"<p><p>Intra-articular injections aimed at correcting underlying pathophysiological processes and providing pain relief are essential for managing knee osteoarthritis (KOA). Collagen, the primary component of articular cartilage, has a long half-life, making it a promising candidate for intra-articular injections with a low risk of serious side effects. The first of the two cases in this report involved a woman in her early 70s with a 6-year history of persistent left knee pain. The second case involved a woman in her mid-50 s with a >7-year history of right knee pain. Both patients received hyaluronic acid injections every 6 months, totaling 10 injections over 5 years. They were diagnosed with Kellgren-Lawrence grade 2 KOA. The patients received two 3-mL intra-articular injections of 6% collagen, administered at baseline and 6 months later. Improvements in clinical outcomes, including visual analog scale scores and Western Ontario and McMaster Universities Osteoarthritis Index scores, were observed and maintained in both patients, with no side effects reported. In summary, when collagen injections were administered to these two patients with KOA, clinical improvements lasted approximately 6 months, and repeated treatments demonstrated efficacy and safety similar to the initial course.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241291735"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of dupilumab in a patient with metastatic clear cell renal cell carcinoma.","authors":"César Ferreira, Egídio Freitas, Tiago Torres","doi":"10.1177/03000605241297551","DOIUrl":"10.1177/03000605241297551","url":null,"abstract":"<p><p>This case report evaluated the efficacy and safety of dupilumab, a monoclonal antibody targeting interleukin-4 and interleukin-13, in a patient with atopic dermatitis (AD) and a history of metastatic renal cancer. Over 20 months of follow-up, the patient experienced significant improvement in AD symptoms without any recurrence of cancer. In addition to not stimulating carcinogenesis, dupilumab might synergistically inhibit tumor-induced immunosuppression, thereby potentially preventing tumor progression. This case suggests that dupilumab could be a viable treatment option for patients with AD and a history of solid neoplasms, filling a critical gap in current therapeutic approaches. Current evidence indicates that dupilumab does not promote cancer progression, but further research is necessary to confirm its long-term safety in this population. To establish robust scientific evidence and develop precise clinical guidelines, future studies should be randomized, controlled, and large-scale. This will help provide a definitive understanding of the safety and efficacy of dupilumab in patients with a history of cancer and inform clinical practice. In summary, although the initial findings are promising, comprehensive research is essential to ensure the optimal management of AD in patients with a history of malignancies.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241297551"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the use of dexmedetomidine during the perioperative period to improve postoperative sleep quality in patients undergoing surgery.","authors":"Chengying Ji, Xiaodong Su, Chaohui Gao, Qijing Liu, Ying Liu, Qian Fu, Boxiong Gao, Yatao Liu","doi":"10.1177/03000605241290715","DOIUrl":"10.1177/03000605241290715","url":null,"abstract":"<p><p>There is a high incidence of postoperative sleep and sleep architecture disorders in patients undergoing surgery, and dexmedetomidine (DEX) is commonly used to improve postoperative sleep quality and ameliorate the adverse effects of poor sleep on various organ systems. The continuous intraoperative intravenous infusion of DEX, the addition of DEX to postoperative intravenous analgesia pumps, and the continuous infusion of DEX after admission to the intensive care unit are often used clinically to improve postoperative sleep quality at doses of 0.1 to 0.7 μg/kg/hour, but the effects of DEX on sleep quality and structure identified in these studies have been inconsistent. Thus, it is unclear whether DEX improves postoperative sleep quality. The various methods of administering DEX to improve postoperative sleep quality have differing effects, the route used modifies the effect of DEX on sleep structure, and the intrinsic mechanism whereby DEX improves sleep quality remains to be fully investigated. In the present review, we describe new directions for future research into the effects of DEX on postoperative sleep quality and the mechanisms involved, which should help guide the design of further studies. This narrative review was completed according to the Scale for the Assessment of Narrative Review Articles (SANRA).</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241290715"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder triggered by herpes zoster: a case report and literature review.","authors":"Yingjie Hua, Andi Xu, Huifen Huang, Shuiwei Xia, Junlin Chen, Siyu Lu, Xufang Huang, Zhongwei Zhao, Dan Wu","doi":"10.1177/03000605241281690","DOIUrl":"10.1177/03000605241281690","url":null,"abstract":"<p><p>This paper presents the case of a 45-year-old woman who developed aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD) approximately 6 weeks after a herpes zoster infection. Her initial symptoms included area postrema syndrome, which was marked by persistent nausea, vomiting, and belching. This report also provides a summary of the demographic and clinical features, disease progression, magnetic resonance imaging findings, cerebrospinal fluid analysis, treatment plans, and recovery outcomes of 11 patients-including this case and 10 others reported in the literature since 2008-who developed AQP4 antibody-positive NMOSD following herpes zoster infection. This review aims to improve clinicians' understanding of the characteristics, treatment, and prognosis of this disease. It also highlights the importance for pain management specialists to consider central pain and use the MIDNIGHTS or VINDψCATE mnemonic devices to systematically consider the differential diagnoses of a patient's new pain symptoms.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241281690"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjögren's syndrome positive for isolated anti-Ro52/SS-A antibody and anti-centromere antibody.","authors":"Hideki Nakamura, Masako Tsukamoto, Kinya Nagata, Yosuke Nagasawa, Kumiko Akiya, Hirotake Inomata, Masahiro Nishihara, Shin-Ya Asatani, Noboru Kitamura, Hisataka Kitano, Jun Shoji, Yu Iwabuchi, Toshiyuki Ishige, Hiroyuki Hao","doi":"10.1177/03000605241293986","DOIUrl":"10.1177/03000605241293986","url":null,"abstract":"<p><p>This current case report describes a Japanese woman in her 80s with xerostomia who presented with salivary gland dysfunction. She was positive for isolated anti-Ro52/SS-A antibody as determined by a chemiluminescent enzyme immunoassay and positive on a fluorescence enzyme immunoassay that recognizes both Ro52 and Ro60 antigens. A high serum concentration of anti-Ro52/SS-A antibody was determined by an enzyme-linked immunosorbent assay. A high anti-centromere antibodies (ACA) titre was also observed. Although Raynaud's phenomenon or a high serum immunoglobulin G concentration were not observed, Masson-trichrome staining of the patient's labial salivary glands showed considerable fibrosis. Her serum type I and type II interferon concentrations were normal. The present patient is the first with Sjögren's syndrome (SS) to exhibit isolated anti-Ro52/SS-A antibody and ACA without anti-Ro60/SS-A antibody. This current case report presents her case together with those of four other SS patients who were positive for isolated anti-Ro52/SS-A antibody. The SS literature also includes cases positive for ACA and describes clinical characteristics. The other four SS patients with isolated anti-Ro52/SS-A antibody described here had no ACA; interstitial pneumonia and polyneuropathy were observed in these cases, although there was no consistent tendency regarding types I and II interferon.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241293986"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative vision loss after sequential lower extremity fracture surgery: a case report.","authors":"Ruimin Luo, Liji Lu, Yuyuan You","doi":"10.1177/03000605241300048","DOIUrl":"10.1177/03000605241300048","url":null,"abstract":"<p><p>Perioperative vision loss (POVL) is a rare but serious complication, most frequently reported after cardiac and prone spinal surgeries. POVL following lower extremity surgery is uncommon. We herein report a case of POVL in a man in his mid-thirties after a third surgery to repair a lower extremity fracture. The patient developed vision loss 3 hours postoperatively following sequential surgeries for a lower extremity fracture. Before the third surgery, he was in a hypercoagulable state, and tranexamic acid was administered to reduce intraoperative blood loss. After POVL occurred, anticoagulant and antithrombotic agents, as well as high-dose steroid pulse therapy, were promptly administered. The patient's vision recovered 3 days later, with no abnormalities found during follow-up visits over the next 6 months. For patients at high risk of thrombosis, POVL warrants careful attention. The coagulation system should be kept as stable as possible, and medications that may promote thrombosis, such as tranexamic acid, should be used cautiously.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300048"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-energy injuries, combined ligamentous injuries, and joint incongruity as predictors of postoperative shoulder dysfunction in AC joint dislocation surgery.","authors":"Xing-Fei Zhu, Zhiyuang Wang, Hai-Feng Li, Jian Fan","doi":"10.1177/03000605241300084","DOIUrl":"10.1177/03000605241300084","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors associated with postoperative shoulder joint dysfunction in patients who underwent surgical intervention for acromioclavicular (AC) joint dislocation, with the aim of enhancing preoperative counselling, surgical planning, and postoperative management to optimize functional outcomes.</p><p><strong>Methods: </strong>Patients who underwent surgery for AC joint dislocation between January 2018 and January 2023 at a hospital orthopaedic centre were enrolled into this retrospective study. Inclusion criteria were patients aged ≥18 years with a documented AC joint dislocation who underwent surgical treatment and had a minimum follow-up period >1 year. Patients with pre-existing shoulder conditions, prior shoulder surgeries, or incomplete medical records were excluded. Visual Analog Scale pain score ≥5 and Constant-Murley Score ≤70 was considered indicative of shoulder joint dysfunction. Statistical analyses included univariate and multivariate logistic regression to identify independent risk factors for postoperative shoulder joint dysfunction.</p><p><strong>Results: </strong>Among 208 included patients, 56 (27%) exhibited shoulder joint dysfunction at the final follow-up. High-energy injury mechanisms, combined coracoclavicular ligament injuries, and lack of coronal plane congruity were identified as significant predictors of postoperative dysfunction. Specifically, high-energy injuries (odds ratio [OR] 5.493, 95% confidence interval [CI] 2.068, 14.590), combined coracoclavicular ligament injuries (OR 0.118, 95% CI 0.032, 0.432), and lack of coronal plane congruity (OR 2.540, 95% CI 1.197, 5.387) were associated with an increased risk of poor shoulder function postoperatively. Other factors, such as age, injury mechanism, and postoperative exercise compliance also contributed to the outcomes. Level of evidence: iv.</p><p><strong>Conclusions: </strong>Injury mechanism, ligamentous injuries, and joint congruity are important in determining postoperative shoulder function. Accurate joint reduction and diligent postoperative rehabilitation are crucial for optimal recovery. These findings provide valuable insights for improving patient care and surgical outcomes in AC joint dislocation treatment. Further research is needed to validate these findings and explore additional factors that may influence postoperative shoulder function.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300084"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: targeted therapy of malignant pleural mesothelioma with anaplastic lymphoma kinase receptor tyrosine kinase gene fusion mutation by crizotinib.","authors":"Yufeng Wu, Yuhua Zhao, Limeng Yu, Ruilin Wang, Wen Feng, Yingxi Wu, Lili Wang, Haiyang Chen, Zhen He, Qiming Wang","doi":"10.1177/03000605241287320","DOIUrl":"10.1177/03000605241287320","url":null,"abstract":"<p><p>Malignant mesothelioma is a rare highly invasive tumour originating from the mesothelial cells of the pleura, peritoneum and pericardium. Malignant pleural mesothelioma (MPM) is the most common type in all malignant mesothelioma. The onset of MPM is associated with exposure to asbestos and it can have an incubation period of up to 40 years. The incidence of MPM has been increasing worldwide in recent years, so more attention has been focused on its diagnosis, treatment and prognosis. Activating mutations, amplifications and fusions/rearrangements of the anaplastic lymphoma kinase receptor tyrosine kinase (<i>ALK</i>) gene are commonly seen in patients with non-small cell lung cancer. However, it is rare in MPM. This current case report describes a female patient with advanced MPM with an <i>ALK</i> gene fusion mutation. In this particular case, treatment with crizotinib demonstrated some initial efficacy, which suggests that this might be a promising strategy for patients with advanced MPM with an <i>ALK</i> gene mutation. This required further research and evaluation in the future.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241287320"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synergistic effects of platelet-rich plasma and negative pressure wound therapy in cavitary infected wounds: a single-centre experience.","authors":"Kun Qian, Wen-Xiu Bao, Na Zuo, Shuai Wang, Wei Ding","doi":"10.1177/03000605241300064","DOIUrl":"10.1177/03000605241300064","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of the combined application of platelet-rich plasma (PRP) and negative pressure wound therapy (NPWT) in cavitary infected wounds, in addition to the parameter settings of NPWT.</p><p><strong>Methods: </strong>The outcomes of patients with cavitary wounds who received debridement with either PRP plus NPWT (PRP group) or NPWT alone (controls) as part of their treatment protocol were retrospectively compared by examining preoperative and postoperative data on high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, neutrophil percentage, bacterial cultures, pain (measured using visual analogue scale [VAS] scores), postoperative hospitalization duration, and effective hospitalization days.</p><p><strong>Results: </strong>A total of 24 patients were included (11 who received PRP plus NPWT and 13 who received NPWT alone). Postoperative hs-CRP levels, ESR, VAS scores, and effective hospitalization days were found to be significantly reduced in the PRP group versus controls. Moreover, the PRP group exhibited a significantly elevated rate of bacterial culture conversion at postoperative day 3.</p><p><strong>Conclusions: </strong>The integration of surgical debridement with PRP and NPWT in the management of infected cavitary wounds may expedite infection containment and bacterial eradication, stimulate granulation tissue formation, and facilitate cavity closure, offering a novel and uncomplicated approach to wound healing.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241300064"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective cohort study on the association between nutritional status and prognosis in COVID-19 patients with severe and critical infection.","authors":"Shuangyun Gou, Dan Tang, Weiyi Li, Yu Qiu, Xiaoping Xu, Li Yang, Li Jiang","doi":"10.1177/03000605241292326","DOIUrl":"10.1177/03000605241292326","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between nutritional scoring systems, nutritional support methods, and the prognosis of severe and critically ill patients infected with the Omicron variant of coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>Patients with confirmed Omicron variant severe and critical COVID-19, who were admitted to Chongqing Medical University First Hospital between December 2022 and January 2023, were enrolled into this retrospective study. Clinical data of patients who survived for 28 days were compared with those who died during the same period. Nutritional status was assessed using the 2002 Nutrition Risk Screening (NRS) tool and Prognostic Nutritional Index (PNI). Factors influencing patient mortality were identified by multivariate logistic regression, and the relationship between patient nutrition and mortality as the disease progressed was illustrated using Kaplan-Meier curves. The study was registered on the ChiCTR platform (No. ChiCTR2300067595).</p><p><strong>Results: </strong>A total of 508 patients were included (349 survivors and 159 non-survivors). Significant differences were found in sex, age, NRS score, PNI score, albumin level, lymphocyte count, chronic comorbidities, mechanical ventilation, neutrophil count, procalcitonin, and platelet count between survivors and non-survivors. Multivariate analysis revealed that high NRS score (OR 3.87, 95% CI, 1.97, 7.63), fourth-level nutritional support (combined enteral and parenteral nutrition; OR 7.89, 95% CI, 1.32, 47.28), chronic comorbidities (OR 4.03, 95% CI, 1.91, 8.51), and mechanical ventilation (OR 6.03, 95% CI, 3, 12.13) were risk factors for mortality (OR > 1). The malnutrition rate among patients with NRS ≥ 3 was 41.93%. The median (interquartile range) PNI score was 38.20 (35.65, 41.25) for survivors versus 32.65 (29.65, 36.58) for non-survivors. The mortality rate was higher in patients with high nutritional risk within 28 days of hospitalization. The descending order for mortality rate in patients receiving different nutritional support was: dual parenteral and enteral nutrition, no nutritional intervention, single enteral nutrition, and single parenteral nutrition.</p><p><strong>Conclusion: </strong>A high proportion of severe and critically ill patients with COVID-19 experience malnutrition, and various factors are associated with their prognosis. High nutritional risk is significantly related to patient mortality. Early assessment using NRS or PNI is crucial for these patients, and personalized interventions should be implemented to improve overall nutritional status, maintain organ function, and enhance the body's antiviral defence.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"52 11","pages":"3000605241292326"},"PeriodicalIF":1.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}