Journal of International Medical Research最新文献_第8页

Cardiac function and quality of life improvement with fasudil hydrochloride in patients with diabetes post-PCI: a randomized controlled trial.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605241311403

Xuejia Yang, Qian Li, Yaning Liu, Ran Chen, Yanjing Liu, Chenghui Sun, Licha Kong, Qiuli Dong

{"title":"Cardiac function and quality of life improvement with fasudil hydrochloride in patients with diabetes post-PCI: a randomized controlled trial.","authors":"Xuejia Yang, Qian Li, Yaning Liu, Ran Chen, Yanjing Liu, Chenghui Sun, Licha Kong, Qiuli Dong","doi":"10.1177/03000605241311403","DOIUrl":"10.1177/03000605241311403","url":null,"abstract":"Objective: We assessed the efficacy of fasudil hydrochloride, a Rho-kinase inhibitor, as adjunct therapy for enhancing cardiac function, managing blood sugar, and improving quality of life in patients with diabetes who have coronary heart disease (CHD) and who underwent percutaneous coronary intervention (PCI).Methods: We conducted a randomized controlled trial including 100 patients with diabetes and CHD who underwent PCI. Participants were randomly assigned to an experimental group receiving fasudil hydrochloride plus standard therapy or a control group receiving standard therapy alone. Treatment outcomes were evaluated over 3 months, focusing on cardiac function, blood sugar levels, and quality of life across physical, social, activities of daily living, and psychological domains.Results: The experimental group showed significant improvement in cardiac function and blood sugar control, compared with the control group. Additionally, quality of life scores were markedly higher for the experimental group in all evaluated domains.Conclusions: Fasudil hydrochloride effectively targets endothelial dysfunction and atherosclerosis, contributing to better cardiac performance and metabolic regulation. These effects translate into improved post-PCI quality of life for patients with diabetes and CHD. As an adjunct to standard PCI therapy, fasudil hydrochloride treatment offers a promising strategy for enhancing clinical outcomes in this high-risk patient population.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605241311403"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315019

Hong Zhang, Minmin Yu, Li Li, Chen Chen, Qinyuan He

{"title":"Obesity-related indices are associated with self-reported infertility in women: findings from the National Health and Nutrition Examination Survey.","authors":"Hong Zhang, Minmin Yu, Li Li, Chen Chen, Qinyuan He","doi":"10.1177/03000605251315019","DOIUrl":"10.1177/03000605251315019","url":null,"abstract":"Objective: Obesity can contribute to infertility, but the exact relationship between infertility risk and obesity-related measurements like waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CoI), and A body shape index (ABSI) in women is uncertain. We investigated the association between these indices and female infertility.Methods: In this cross-sectional study, we used National Health and Nutrition Examination Survey data (2013-2018). We used weighted multivariable logistic regression analysis, receiver operating characteristic (ROC) curves, and subgroup analysis, as well as propensity score matching.Results: Among 3373 participants, 344 (10.2%) reported infertility. A significant link between higher infertility risk and increased WHtR, BRI, CoI, ABSI, and body mass index (BMI) was found. Multivariable logistic regression analysis showed WHtR (odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.14-1.42), BRI (OR = 1.09, 95% CI: 1.05-1.14), CoI (OR = 1.36, 95% CI: 1.18-1.56), ABSI (OR = 1.22, 95% CI: 1.12-1.33), and BMI (OR = 1.03, 95% CI: 1.02-1.05) were significantly associated with female infertility. CoI had the best diagnostic performance (area under the ROC curve 0.628, 95% CI: 0.597-0.658).Conclusions: Obesity-related indices were positively linked to infertility risk among women in the United States. These indices serve as valuable tools for assessing female infertility risk.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315019"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of potential markers of early infection in patients undergoing elective colorectal malignancy surgery.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315920

Bulent Calik, Sebnem Calik, Mehmet Yildirim, Erdinç Kamer, Selma Tosun, Selcuk Kavak

{"title":"Evaluation of potential markers of early infection in patients undergoing elective colorectal malignancy surgery.","authors":"Bulent Calik, Sebnem Calik, Mehmet Yildirim, Erdinç Kamer, Selma Tosun, Selcuk Kavak","doi":"10.1177/03000605251315920","DOIUrl":"10.1177/03000605251315920","url":null,"abstract":"Objectives: We aimed to investigate the value of leukocyte biomarkers and disease scores for the early detection of infection in patients who have undergone elective colorectal surgery for malignancy.Methods: We conducted a prospective study at a training and research hospital. Patients who developed infection were considered to be an Infection group, and the others were regarded as a Control group. For individuals in both groups, the Sequential Organ Failure Assessment Score (SOFA), quick SOFA, and National Early Warning Score (NEWS) were calculated and blood samples were collected for flow cytometry analysis. A model was developed using logistic regression analysis to identify parameters that were predictive of mortality.Results: One hundred thirty-two patients were included in the study. Infections developed in 36 (27.3%) of the participants, of which 14 (38.9%) were intra-abdominal, 10 (27.8%) were pneumonia, 8 (22.2%) were superficial incisional infections, and 4 (11.1%) were urinary tract infections. The NEWS was the most effective parameter for the detection of early infection in patients undergoing surgery for colorectal malignancy.Conclusion: The NEWS score can be easily used to predict infection soon after surgery for colorectal malignancy.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315920"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lumbar sympathetic pulsed radiofrequency combined with continuous epidural infusion for treatment of painful diabetic neuropathy: A report of two cases and a literature review. 腰交感神经脉冲射频结合连续硬膜外输注治疗糖尿病疼痛性神经病变：两例病例报告和文献综述。

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 Epub Date: 2020-06-09 DOI: 10.1177/0300060518786903

Shao-Jun Li, Dan Feng

引用次数: 0

Spontaneous hemoperitoneum in the second trimester of pregnancy with a favorable outcome: a case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251317995

Lirong Fu, Li Zhang, Lijuan Xu, Peirong Xu, Kai Liu, Zhuyun Ding

引用次数: 0

Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251317980

Pengyan Yin, Miaohui Duan, Lingyao Deng, Tianli Li, Xuan Huang, Raohong Fang, Hailong Li, Binliang Bai

{"title":"Initial misdiagnosis to a revised diagnosis of pulmonary paragonimiasis with elevated serum immunoglobulin G4 concentrations: a case report.","authors":"Pengyan Yin, Miaohui Duan, Lingyao Deng, Tianli Li, Xuan Huang, Raohong Fang, Hailong Li, Binliang Bai","doi":"10.1177/03000605251317980","DOIUrl":"10.1177/03000605251317980","url":null,"abstract":"An elevation in serum immunoglobulin (Ig) G4 concentrations at only one time point is not a definitive diagnostic marker for IgG4-related diseases. We report two cases of pulmonary paragonimiasis with elevated serum IgG4 concentrations. Patient 1 was a woman in her late 40s with cough and dyspnea for 1 week. Patient 2 was a woman in her late 60s with a cough, bloody sputum, chest pain, and wheezing for over 1 month. Patient 1 had eosinophilia, high IgE, IgG, and IgG4 concentrations, right pleural effusion, and lung lesions, resembling tuberculosis. Patient 2 had cavitary lung lesions, pleural involvement, and eosinophilia, and high IgE, IgG, and IgG4 concentrations, with a history of eating raw river crabs. Both patients tested positive for Paragonimus antibodies. Patient 1 received 2 months of anti-parasitic treatment, while Patient 2 had 1 week of treatment. Patient 2 showed improvement and was discharged with normalized Ig concentrations. Increased serum IgG4 concentrations, in conjunction with elevated concentrations of IgG, IgE and eosinophil counts, and a history of travel or residence in areas endemic for paragonimiasis, can be used to distinguish pulmonary paragonimiasis from other etiologies of pneumonia.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251317980"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of ELISA: a review and update on best laboratory practices for quantifying peptides and proteins in biological fluids.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315913

Suleyman Aydin, Elif Emre, Kader Ugur, Mustafa Ata Aydin, İbrahim Sahin, Vedat Cinar, Taner Akbulut

引用次数: 0

Aspirin does not confer protection against major ischemic vascular events in patients diagnosed with rheumatoid arthritis.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315359

Chao Gao, Qiqi Hou, Hongxia Cao, Cangtuo Li, Xu Peng, Quanle Han, Shouling Wu, Kangbo Li

{"title":"Aspirin does not confer protection against major ischemic vascular events in patients diagnosed with rheumatoid arthritis.","authors":"Chao Gao, Qiqi Hou, Hongxia Cao, Cangtuo Li, Xu Peng, Quanle Han, Shouling Wu, Kangbo Li","doi":"10.1177/03000605251315359","DOIUrl":"10.1177/03000605251315359","url":null,"abstract":"Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammatory arthritis and extra-articular involvement. Patients with RA are at increased risk of developing cardiovascular diseases. This retrospective cohort study aimed to determine whether acetylsalicylic acid (aspirin [ASA]) protects against major ischemic vascular events in patients diagnosed with RA.Methods: Patients with RA were recruited from a population of 118, 500 participants who were enrolled into the Kailuan Cohort Study between 2014 and 2016. Information regarding demographic characteristics, anthropometric measures, and medical histories were documented. Patients with RA who underwent ASA therapy were propensity score matched at a ratio of 1:4 with patients with RA who did not receive ASA. The risk of ischemic vascular events (myocardial infarction and ischemic stroke) was examined. The relationship between ASA therapy and major ischemic vascular events was analyzed by Cox proportional hazards regression.Results: A total of 939 patients with RA were included (189 who received ASA and 750 who did not). During the 3.3-year follow-up, six and 35 major ischemic vascular events occurred in the ASA and non-ASA groups, respectively, with no significant between-group difference in the cumulative incidence of such events. Cox proportional hazards regression analysis showed that ASA therapy was not associated with major vascular ischemic events and its subtypes.Conclusions: ASA did not confer protection against major ischemic vascular events in patients diagnosed with RA.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315359"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605231220807

Chao Chen, Qiwu Wang, Jiwen Liu

{"title":"Curcumin inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells via IGF-1/PI3K/Akt pathway.","authors":"Chao Chen, Qiwu Wang, Jiwen Liu","doi":"10.1177/03000605231220807","DOIUrl":"10.1177/03000605231220807","url":null,"abstract":"Objective: This study aimed to investigate the possible mechanism by which curcumin inhibits human prostate cancer (PCa) and castration-resistant prostate cancer (CRPC).Methods: CRPC cells were treated with curcumin and their viability was assessed by MTT assay and apoptosis was detected by annexinV/propidium iodide double-staining and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays. Expression levels of insulin-like growth factor 1 receptor (IGF-1R) were determined by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting. Phosphoinositide 3-kinase (PI3K), Akt, and forkhead box protein O1 (FOXO1) expression and phosphorylation were assessed by western blotting.Results: The highly expressed PCa-related molecule IGF-1R was down-regulated in CRPC cells after curcumin treatment, as determined by RT-qPCR and western blotting. In addition, curcumin inhibited the tumor-related PI3K/Akt signaling pathway in CRPC cells. Moreover curcumin down-regulated the IGF-1/PI3K/Akt signaling pathway in tumors derived from CRPC cells.Conclusions: These results demonstrated that curcumin inhibits growth and triggers apoptosis of human CRPC cells via the IGF-1/PI3K/Akt pathway, thus providing potential new therapeutic strategies for PCa and CRPC.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605231220807"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11806470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of 0.01 mM strontium on human periodontal ligament stem cell osteogenic differentiation via the Wnt/β-catenin signaling pathway.

IF 1.4 4区医学

Journal of International Medical Research Pub Date : 2025-02-01 DOI: 10.1177/03000605251315024

Tongke Sun, Dan Ma, Yang Song, Jing Hu, Ziqing Yang, Xu Wang, Jun Zhang

{"title":"Effects of 0.01 mM strontium on human periodontal ligament stem cell osteogenic differentiation via the Wnt/β-catenin signaling pathway.","authors":"Tongke Sun, Dan Ma, Yang Song, Jing Hu, Ziqing Yang, Xu Wang, Jun Zhang","doi":"10.1177/03000605251315024","DOIUrl":"10.1177/03000605251315024","url":null,"abstract":"Objectives: Strontium (Sr2+) is a crucial trace element in humans, mainly present in the bones. We investigated the effects of Sr2+ on human periodontal ligament stem cell (hPDLSC) proliferation and osteogenesis and the relevant pathways.Methods: hPDLSCs were harvested from extracted premolars and characterized by flow cytometry, then cultured and treated with various Sr2+ concentrations. Cell-counting kit-8 (CCK-8) assays were used to assess hPDLSC proliferation, with alkaline phosphatase (ALP) staining, Alizarin red S staining, and ALP activity assays used to analyze their osteogenic capacity. Quantitative reverse transcription polymerase chain reaction and western blots were used to examine the expression levels of relevant factors, such as collagen I (COL-1), ALP, and Runx family transcription factor 2 (RUNX2). Moreover, tankyrase inhibitor XAV939 treatment was used to investigate the role of Sr2+ in the canonical Wnt/β-catenin signaling pathway.Results: The hPDLSCs were successfully isolated and cultured in vitro. A 0.01 mM Sr2+ concentration significantly enhanced hPDLSC proliferation and osteogenic differentiation. However, XAV939-mediated inhibition of the canonical Wnt/β-catenin pathway could reverse the Sr2+-induced osteogenic effects.Conclusions: Sr2+ can enhance hPDLSC proliferation and osteogenesis by stimulating canonical Wnt/β-catenin signaling, suggesting it may play a critical role in periodontal regeneration and has clinical application potential.","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 2","pages":"3000605251315024"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0