{"title":"2019冠状病毒病相关妊娠期肝损伤1例报告","authors":"Nan Yu, Yi-Yao Huang, Ling Feng, Qian Liu","doi":"10.1177/03000605251344150","DOIUrl":null,"url":null,"abstract":"<p><p>Liver injury is an increasingly recognized extrapulmonary manifestation of coronavirus disease 2019 (COVID-19), particularly during pregnancy due to overlapping physiological and pathological changes. A 26-year-old primigravida at 24<sup>+4</sup> weeks of gestation presented with fever, chills, weakness, and sore throat, who was later confirmed to be severe acute respiratory syndrome coronavirus 2-positive. Laboratory tests revealed lymphopenia, elevated liver enzymes, low platelet count, increased D-dimer level, high total bilirubin level, and elevated lactate dehydrogenase levels. After thorough evaluation, these findings were attributed to COVID-19-associated liver injury. The patient was provided with supportive care and symptomatic treatment, resulting in gradual normalization of liver function. She was discharged at 26 weeks of gestation in stable condition. This case highlights the importance of considering COVID-19-associated liver injury in pregnant patients presenting with hepatic dysfunction, where prompt recognition and conservative management can help achieve favorable maternal outcomes.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 5","pages":"3000605251344150"},"PeriodicalIF":1.5000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120285/pdf/","citationCount":"0","resultStr":"{\"title\":\"Coronavirus disease 2019-associated liver injury in pregnancy: A case report.\",\"authors\":\"Nan Yu, Yi-Yao Huang, Ling Feng, Qian Liu\",\"doi\":\"10.1177/03000605251344150\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Liver injury is an increasingly recognized extrapulmonary manifestation of coronavirus disease 2019 (COVID-19), particularly during pregnancy due to overlapping physiological and pathological changes. A 26-year-old primigravida at 24<sup>+4</sup> weeks of gestation presented with fever, chills, weakness, and sore throat, who was later confirmed to be severe acute respiratory syndrome coronavirus 2-positive. Laboratory tests revealed lymphopenia, elevated liver enzymes, low platelet count, increased D-dimer level, high total bilirubin level, and elevated lactate dehydrogenase levels. After thorough evaluation, these findings were attributed to COVID-19-associated liver injury. The patient was provided with supportive care and symptomatic treatment, resulting in gradual normalization of liver function. She was discharged at 26 weeks of gestation in stable condition. This case highlights the importance of considering COVID-19-associated liver injury in pregnant patients presenting with hepatic dysfunction, where prompt recognition and conservative management can help achieve favorable maternal outcomes.</p>\",\"PeriodicalId\":16129,\"journal\":{\"name\":\"Journal of International Medical Research\",\"volume\":\"53 5\",\"pages\":\"3000605251344150\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120285/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of International Medical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/03000605251344150\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of International Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03000605251344150","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Coronavirus disease 2019-associated liver injury in pregnancy: A case report.
Liver injury is an increasingly recognized extrapulmonary manifestation of coronavirus disease 2019 (COVID-19), particularly during pregnancy due to overlapping physiological and pathological changes. A 26-year-old primigravida at 24+4 weeks of gestation presented with fever, chills, weakness, and sore throat, who was later confirmed to be severe acute respiratory syndrome coronavirus 2-positive. Laboratory tests revealed lymphopenia, elevated liver enzymes, low platelet count, increased D-dimer level, high total bilirubin level, and elevated lactate dehydrogenase levels. After thorough evaluation, these findings were attributed to COVID-19-associated liver injury. The patient was provided with supportive care and symptomatic treatment, resulting in gradual normalization of liver function. She was discharged at 26 weeks of gestation in stable condition. This case highlights the importance of considering COVID-19-associated liver injury in pregnant patients presenting with hepatic dysfunction, where prompt recognition and conservative management can help achieve favorable maternal outcomes.
期刊介绍:
_Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis.
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Print ISSN: 0300-0605