{"title":"真性红细胞增多症并发继发性红斑性肢痛症的疼痛性糖尿病神经病变1例。","authors":"Hong Zhang, Zhengran Qin, Xiaohong Feng","doi":"10.1177/03000605251382382","DOIUrl":null,"url":null,"abstract":"<p><p>This report describes the case of a 62-year-old woman with type 2 diabetes and painful diabetic peripheral neuropathy, who, despite standard treatment, experienced persistent symptoms. Further investigation revealed erythromelalgia secondary to polycythemia vera, confirmed by bone marrow biopsy and <i>JAK2</i> V617F mutation. The patient received a multidisciplinary regimen, including pregabalin, aspirin, and interferon-alpha, resulting in significant symptom relief and improved hematologic parameters. Follow-up over 2 years confirmed sustained symptom resolution, highlighting the importance of considering concurrent or secondary pain factors when diagnosing and treating refractory neuropathic pain to avoid misdiagnosis or missed diagnosis.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 10","pages":"3000605251382382"},"PeriodicalIF":1.5000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489223/pdf/","citationCount":"0","resultStr":"{\"title\":\"Painful diabetic neuropathy complicated with secondary erythromelalgia in polycythemia vera: A case report.\",\"authors\":\"Hong Zhang, Zhengran Qin, Xiaohong Feng\",\"doi\":\"10.1177/03000605251382382\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This report describes the case of a 62-year-old woman with type 2 diabetes and painful diabetic peripheral neuropathy, who, despite standard treatment, experienced persistent symptoms. Further investigation revealed erythromelalgia secondary to polycythemia vera, confirmed by bone marrow biopsy and <i>JAK2</i> V617F mutation. The patient received a multidisciplinary regimen, including pregabalin, aspirin, and interferon-alpha, resulting in significant symptom relief and improved hematologic parameters. Follow-up over 2 years confirmed sustained symptom resolution, highlighting the importance of considering concurrent or secondary pain factors when diagnosing and treating refractory neuropathic pain to avoid misdiagnosis or missed diagnosis.</p>\",\"PeriodicalId\":16129,\"journal\":{\"name\":\"Journal of International Medical Research\",\"volume\":\"53 10\",\"pages\":\"3000605251382382\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489223/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of International Medical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/03000605251382382\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of International Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03000605251382382","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Painful diabetic neuropathy complicated with secondary erythromelalgia in polycythemia vera: A case report.
This report describes the case of a 62-year-old woman with type 2 diabetes and painful diabetic peripheral neuropathy, who, despite standard treatment, experienced persistent symptoms. Further investigation revealed erythromelalgia secondary to polycythemia vera, confirmed by bone marrow biopsy and JAK2 V617F mutation. The patient received a multidisciplinary regimen, including pregabalin, aspirin, and interferon-alpha, resulting in significant symptom relief and improved hematologic parameters. Follow-up over 2 years confirmed sustained symptom resolution, highlighting the importance of considering concurrent or secondary pain factors when diagnosing and treating refractory neuropathic pain to avoid misdiagnosis or missed diagnosis.
期刊介绍：
_Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis.
As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible.
Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence.
Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements.
Print ISSN: 0300-0605
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