中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症的关系:一项横断面研究。

IF 1.5 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of International Medical Research Pub Date : 2025-09-01 Epub Date: 2025-09-04 DOI:10.1177/03000605251367610
Tao Zhang, Ya Zhou, Long-Fei Luo, Deng-Jun Ji, Liang Wang, Jun Xie, An-Ning Zhu, Jun-Tao Yan, Zhen Yan, Li Gong, Wu-Quan Sun
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引用次数: 0

摘要

目的肌少症对全球公共卫生造成了重大负担,强调了确定可靠的风险标记物以进行早期发现和干预的紧迫性。本研究旨在阐明中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症之间的关系,并探讨各种协变量如何改变这种关系。方法采用2011-2018年全国健康与营养检查调查9040人的数据进行横断面分析,其中721人被诊断为肌肉减少症。采用多变量logistic回归模型估计中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症之间的比值比和95%置信区间。利用限制三次样条回归分析评估中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症风险之间的非线性关系。亚组分析确定不同亚组中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症之间的关系。考虑到低年龄阈值与肌少症诊断标准之间的冲突,我们对年龄≥40岁的参与者进行了敏感性分析。结果多变量logistic回归分析显示,中性粒细胞与高密度脂蛋白胆固醇之比与肌肉减少症风险呈正相关(优势比为1.16,95%可信区间为1.11 ~ 1.22,P 0.0001)。限制三次样条回归分析显示中性粒细胞与高密度脂蛋白胆固醇比值与肌肉减少症风险之间存在非线性关系(非线性p0.05)。亚组分析表明,性别、种族和高脂血症显著改变了中性粒细胞与高密度脂蛋白胆固醇比率与肌肉减少症风险之间的关系(P为相互作用)
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study.

Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study.

Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study.

Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study.

ObjectiveSarcopenia poses a significant global public health burden, underscoring the urgency of identifying reliable risk markers for early detection and intervention. This study aimed to elucidate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia as well as explore how various covariates modify this relationship.MethodsA cross-sectional analysis was performed using data from 9040 individuals who participated in the National Health and Nutrition Examination Survey 2011-2018, of whom 721 were diagnosed with sarcopenia. Multivariable logistic regression models were employed to estimate the odds ratios and 95% confidence intervals for the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Restricted cubic spline regression analysis was utilized to assess the nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk. Subgroup analysis was performed to identify the relationship between different subgroups of neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia. Considering the conflict between the lower age threshold and the diagnostic criteria for sarcopenia, we conducted sensitivity analysis among participants aged ≥40 years.ResultsMultivariable logistic regression analysis revealed that the neutrophil-to-high-density lipoprotein cholesterol ratio was positively associated with sarcopenia risk (odds ratio = 1.16, 95% confidence interval: 1.11-1.22, P <0.0001). Restricted cubic spline regression analysis demonstrated a nonlinear relationship between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (nonlinear P <0.05). Subgroup analyses indicated that sex, race, and hyperlipidemia significantly modified the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia risk (P for interaction <0.05).ConclusionsAn elevated neutrophil-to-high-density lipoprotein cholesterol ratio is associated with a high risk of sarcopenia, indicating that the ratio can effectively assess the risk of sarcopenia and may contribute to early diagnosis and preventive intervention.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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