Correlation between neutrophil-to-lymphocyte ratio, red blood cell distribution width, platelet distribution width, and colorectal adenoma: A retrospective cohort study.

Abstract

ObjectiveThe objective of this study was to explore correlations between red blood cell distribution width, neutrophil-to-lymphocyte ratio, platelet distribution width, and colorectal adenomas.MethodsRetrospective analysis of 120 patients undergoing colonoscopy (from January to December 2024) divided into adenoma (n = 60) and control (n = 60) groups. Demographic characteristics, habits, and blood parameters were compared.ResultsSignificant differences in neutrophil-to-lymphocyte ratio, platelet distribution width, and red blood cell distribution width between groups (P < 0.05) were noted. Spearman analysis showed positive correlations: neutrophil-to-lymphocyte ratio and platelet distribution width (r = 0.434), neutrophil-to-lymphocyte ratio and red blood cell distribution width (r = 0.461), and red blood cell distribution width and platelet distribution width (r = 0.424) (P < 0.001). Logistic regression identified neutrophil-to-lymphocyte ratio (odds ratio = 5.027), platelet distribution width (odds ratio = 1.553), and red blood cell distribution width (odds ratio = 9.081) as independent risks.ConclusionElevated neutrophil-to-lymphocyte ratio, platelet distribution width, and red blood cell distribution width are independent risk factors. Early colonoscopy and intervention may serve as non-invasive biomarkers for early screening.