Journal of Functional Biomaterials最新文献

{"title":"Correction: Silva et al. Vertical and Horizontal Ridge Augmentation with Titanium-Reinforced Dense PTFE and Reinforced PTFE Mesh: A Prospective Comparative Case Series. <i>J. Funct. Biomater.</i> 2026, <i>17</i>, 234.","authors":"Liliana Andrea Silva, Pedro Sousa Gomes, Maria Helena Fernandes, Marta García-García, Octavi Camps-Font","doi":"10.3390/jfb17100483","DOIUrl":"10.3390/jfb17100483","url":null,"abstract":"<p><p><b>Missing Informed Consent Statement</b> [...].</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 10","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofabrication and Characterization of Fluorapatite-Coated Poly(lactic-co-glycolic acid) Microscaffolds: Physicochemical Properties and Human Dental Pulp Stem Cell Responses.","authors":"Saya Hadi Raouf, Varvara Platania, Argyro Lamprou, Youri Arntz, Iryna Lysova, Diyar Khalid Bakr, Niaz Hamaghareeb Hamasaeed, Mutlu Özcan, Isaac Maximiliano Bugueno","doi":"10.3390/jfb17090479","DOIUrl":"10.3390/jfb17090479","url":null,"abstract":"<p><p>Biodegradable polymeric scaffolds incorporating bioactive mineral phases are a promising approach for dentin-pulp tissue engineering. Although poly(lactic-co-glycolic acid) (PLGA) microparticles have been widely used as scaffolds due to their biocompatibility and tunable degradation profile, their inherent bioactivity is limited. Furthermore, fluorapatite (FAP), a fluoride-substituted apatite ceramic, exhibits enhanced chemical stability and mineral-related properties that may be useful for regenerative biomaterial design. In this study, we investigated the effect of nano-FAP functionalization on the physicochemical properties of porous PLGA microscaffolds and their interaction with human dental pulp stem cells (hDPSCs). Porous PLGA microscaffolds were fabricated using a double-emulsion solvent evaporation method and subsequently functionalized with FAP suspensions ranging from 0.1 to 5 mg/mL (0.01-0.5% <i>w</i>/<i>v</i>). The scaffolds were evaluated using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), electrical conductivity measurements, cell viability assays, and immunofluorescence. Lower and intermediate FAP concentrations-maintained surface pore accessibility and supported hDPSC viability, whereas the highest concentration (5 mg/mL; 0.5% <i>w</i>/<i>v</i>) reduced visible surface pore size and showed less favorable cellular responses. The 2.5 mg/mL (0.25% <i>w</i>/<i>v</i>) FAP condition provided the most favorable overall balance among the evaluated physicochemical and biological parameters. These preliminary in vitro findings support further investigation of FAP-functionalized PLGA microscaffolds in advanced three-dimensional and in vivo models.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and Rheological Analysis of an Injectable Calcium Hydroxylapatite Dermal Filler with Lattice-Pore Surface Architecture.","authors":"Gi-Woong Hong, Yerin Park, Doo Yeoul Chang, Jeesoo Kook, Young Bin Lim, Ho Lee, Kyu-Ho Yi","doi":"10.3390/jfb17090476","DOIUrl":"10.3390/jfb17090476","url":null,"abstract":"<p><p><b>Background:</b> Hydroxylapatite is a biocompatible calcium-phosphate ceramic used in regenerative biomaterials. Calcium hydroxylapatite (CaHA) fillers combine immediate mechanical support with subsequent extracellular matrix remodeling, and their material behavior depends on microsphere morphology, mineral composition, carrier interactions, and rheology. <b>Objectives:</b> To determine whether a CaHA formulation prepared using Lattice Pore Formation technology (Facetem) exhibits a distinct and internally consistent material profile across microsphere geometry, lattice-pore surface architecture, mineral composition, formulation-level sedimentation, and rheological behavior across dilution ratios, with selected morphology and sedimentation characteristics compared with Radiesse. <b>Methods:</b> Facetem (marketed in the Republic of Korea as DCLASSY) was evaluated as the test product, with Radiesse used as the comparator product. Microspheres were examined using field-emission scanning electron microscopy and laser-diffraction particle-size analysis. Surface morphology was assessed before and after 12 weeks of phosphate-buffered saline (PBS) incubation. Mineral composition was evaluated using X-ray diffraction and inductively coupled plasma optical emission spectroscopy. Extrusion continuity and sedimentation after saline dilution were evaluated, and rheological properties were measured across eight dilution ratios using saline, non-cross-linked hyaluronic acid, and semi-cross-linked hyaluronic acid. <b>Results:</b> Facetem had a mean particle diameter of 34.60 μm, with higher circularity (0.95 versus 0.88) and roundness (0.96 versus 0.85), a lower aspect ratio, and fewer particles below 20 μm (2.10% versus 14.50%) than Radiesse. Micrograin domains formed a lattice-pore surface that showed morphological changes after 12 weeks of PBS incubation while the spherical contour remained recognizable. Hydroxylapatite represented 99.09% of the mineral phase, with a Ca/P ratio of 1.67. Facetem extruded as a continuous strand and showed greater supernatant clarification after dilution. Storage modulus declined with dilution, and semi-cross-linked hyaluronic acid retained more elastic resistance than saline at equivalent ratios. <b>Conclusions:</b> Facetem demonstrated a consistent microsphere population, an organized lattice-pore surface, hydroxylapatite stoichiometry, and diluent-dependent rheology. The integrated analysis defines its physicochemical profile; the PBS findings should be interpreted as morphological stability under non-biological buffer conditions rather than in vivo degradation.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Effects of Horizontal, Vertical, and Combined Misfits in Full-Arch Implant-Supported Titanium Frameworks: A Three-Dimensional Finite Element Analysis.","authors":"Hale Arikan Kalayci, Mustafa Baris Guncu","doi":"10.3390/jfb17090478","DOIUrl":"10.3390/jfb17090478","url":null,"abstract":"<p><p>This study evaluated the effects of misfit type, magnitude, and location on the stress distribution in full-arch screw-retained implant frameworks. A maxillary finite element model with four implants was analyzed under 16 scenarios, characterized by horizontal misfits of 10, 50, 100, and 200 µm; vertical misfits of 10 and 100 µm; and combined 10-10 and 100-100 µm misfits, each positioned anteriorly or posteriorly. Forced seating was simulated using prescribed displacement; no occlusal load or screw preload was applied. Von Mises stresses were evaluated in the framework, occlusal screws, and implants, and principal stresses were assessed in peri-implant bone. Framework stress increased with horizontal misfit magnitude. When the same numerical misfit value (10 or 100 µm) was applied at the same location under otherwise identical model conditions, vertical misfit produced higher framework stress than horizontal misfit, indicating a direction-dependent response associated with different seating deformation modes. The posterior 100-100 µm combined misfit produced the maximum framework (356 MPa), occlusal screw (193 MPa), and implant (250 MPa) stresses. In contrast, the maximum principal stress peaked at the posterior bone site with the anterior 200 µm horizontal misfit (V0 H200 A; 77 MPa), while the most negative minimum principal stress occurred at the posterior bone site with the posterior 200 µm horizontal misfit (V0 H200 P; -52 MPa). Among the tested scenarios, combined misfits yielded the highest framework and screw stresses, whereas implant and bone responses depended on the magnitude and location of the misfit. These findings indicate that the types, magnitudes, and locations of misfits should be considered during framework-fit assessments, with particular attention to combined misfits, before definitive seating.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Effect of Fluoride-Generating Nonthermal Atmospheric Plasmas on In Vitro Triple-Species Oral Biofilms.","authors":"Anushri Warang, Linfeng Wu, Qingsong Yu, Liang Hong, Hongmin Sun","doi":"10.3390/jfb17090477","DOIUrl":"10.3390/jfb17090477","url":null,"abstract":"<p><p>This study investigates the feasibility of fluoride delivery via fluoride-generating nonthermal atmospheric plasma (FNTAP) and its antimicrobial effects on in vitro triple-species oral biofilms. FNTAPs were generated by adding 5 or 10 sccm (standard cubic centimeters per min) 1,1,1,2-tetrafluoroethane (TFE) to atmospheric argon (3000 sccm) nonthermal plasma (ArNTAP). Reactive plasma species were measured in plasma-treated phosphate-buffered saline (PBS). Twenty-four-hour biofilms were constructed from <i>Streptococcus mutans</i>, <i>Streptococcus sanguinis</i>, and <i>Candida albicans</i> for assessing the antimicrobial effects of FNTAPs via viability assays and colony-forming unit (CFU) assays. FNTAP treatments significantly increased the concentrations of F^- and NO₂^- in PBS compared to ArNTAP treatments (<i>p</i> < 0.01), and decreased the concentrations of H₂O₂ and NO₃^- in PBS (<i>p</i> < 0.001, <i>p</i> < 0.05). 5 sccm 2 min FNTAP treatment reduced biofilm viability by 94.12 ± 1.03% (<i>p</i> < 0.001), compared to a 69.32 ± 2.05% (<i>p</i> < 0.001) reduction with ArNTAP. CFU assays showed that FNTAPs were especially efficacious against <i>C. albicans</i>. 5 sccm 3 min FNTAP treatment reduced fungal log₁₀ CFUs by 4.28 ± 0.36 (<i>p</i> < 0.001). Fungal CFUs were below detectable levels for the 10 sccm 2 and 3 min groups, except for two data points in each group. In conclusion, FNTAP effectively produced measurable fluoride in PBS and significantly enhanced antimicrobial efficacy against triple-species biofilms, highlighting its potential as a multifunctional tool for caries control.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Different Surface Modifications on the Reverse Torque Values of Abutment Screws: An In Vitro Study.","authors":"Merve Dede, Ozgun Yusuf Ozyilmaz, Ozge Doganay Ozyilmaz, Gamze Hanci Abay","doi":"10.3390/jfb17090475","DOIUrl":"10.3390/jfb17090475","url":null,"abstract":"<p><p>Evidence regarding tantalum nitride (TaN)-coated gold abutment screws is lacking, and studies on diamond-like carbon (DLC)-coated and anaerobic adhesive-coated abutment screws remain limited. This study evaluated the reverse torque values (RTVs) of abutment screws with different surface modifications. Sixty abutment screws from the same implant system were divided into five groups (<i>n</i> = 12): gold, TaN-coated gold, titanium, DLC-coated titanium, and anaerobic adhesive-coated titanium. Abutments were tightened according to the manufacturer's recommended torque. Specimens were then subjected to cyclic loading (50 N, 1 Hz, 480,000 cycles) in a dual-axis chewing simulator, after which RTVs were evaluated. ANOVA showed a significant difference only for the uncoated gold screw group (<i>p</i> < 0.05). The lowest RTVs were observed in the gold screws. Although the differences among the modified screw groups were not statistically significant, surface-treated screws demonstrated higher and more stable RTVs than their uncoated counterparts. TaN-, DLC-, and anaerobic adhesive-treated screws exhibited higher RTVs following cyclic loading, suggesting that these surface modifications may enhance screw stability and reduce the risk of abutment screw loosening.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descriptive Histological and Histomorphometrical Comparison of Four Xenogeneic and Synthetic Bone Blocks for Mandibular Onlay Augmentation in Rabbits.","authors":"Souichiro Honda, Daniele Botticelli, Erick Ricardo Silva, Samuel Porfirio Xavier, Giovanna Iezzi, Hitoshi Seo, Shunsuke Baba","doi":"10.3390/jfb17090472","DOIUrl":"10.3390/jfb17090472","url":null,"abstract":"<p><strong>Background: </strong>This exploratory study provided a primarily descriptive comparison of two xenogeneic and two synthetic blocks for mandibular onlay augmentation in rabbits.</p><p><strong>Methods: </strong>Twelve rabbits received bilateral block grafts, providing 24 sites allocated to Bio-Oss^® Block, SP-Block, ReproBone^® Block, or Alos Block (<i>n</i> = 6/material). After 10 weeks, undecalcified sections were evaluated within standardized inferior and superior regions. Newly formed bone was the primary outcome; secondary outcomes included residual graft, IBN-like tissue, soft-tissue components, and cross-sectional augmented area. Mixed-effects models accounted for clustering within animals.</p><p><strong>Results: </strong>No statistically significant difference in newly formed bone percentage was detected among biomaterials (<i>p</i> = 0.475). Residual graft differed significantly (<i>p</i> < 0.001) and was lower for all test materials than for Bio-Oss^® Block. ReproBone^® Block consistently exhibited IBN-like tissue (17.3 ± 2.9%). SP-Block showed more intra-compartment soft tissue than Bio-Oss^® Block. Alos Block had the smallest augmented area (12.9 ± 6.1 mm²; adjusted <i>p</i> = 0.001 versus Bio-Oss^® Block), and extra-compartment soft tissue was present in five of six sites.</p><p><strong>Conclusions: </strong>Although newly formed bone percentages did not differ significantly, the biomaterials displayed distinct profiles of scaffold persistence, incorporation, tissue organization, and cross-sectional augmented area at 10 weeks. These features should be considered together when evaluating block biomaterials for onlay augmentation.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptual Evaluation of 3D-Printed Typodont Teeth with Comparable Cutting Forces.","authors":"Alexander Jon Cresswell-Boyes, Aylin Baysan, Graham Roy Davis","doi":"10.3390/jfb17090471","DOIUrl":"10.3390/jfb17090471","url":null,"abstract":"<p><p><b>Background</b>: Pre-clinical training in endodontics relies heavily on typodont teeth to develop operative skills before patient care, but conventional polymer-based typodonts differ from human teeth in their cutting response, requiring greater force and producing an unrealistic cutting experience that often dissatisfies students. <b>Methods</b>: This study evaluated four alternative 3D-printed typodont materials-15 wt.% carbonated hydroxyapatite, 15 wt.% Puraflake^® (glass flake filler), 15 wt.% zinc oxide, and a urethane/triethylene glycol dimethacrylate resin composite-based on their cutting force, post-cut surface roughness, and perceived cutting feel relative to extracted enamel, assessed via a five-point Likert scale questionnaire completed by 46 (<i>n</i> = 46) fourth- and fifth-year dental students. <b>Results</b>: No statistically significant differences in cutting force were detected between the four printed materials and extracted enamel, a finding confirmed using formal two one-sided equivalence testing (TOST); larger confirmatory studies would allow this equivalence to be established with greater statistical precision. Perception scores differed significantly between materials, and fifth-year students rated the dental resin composite significantly more favourably than fourth-year students, with only the composite effect surviving stringent Bonferroni correction across all four material comparisons, underscoring the reliability of this specific finding. Post-cut surface roughness showed a strong, statistically robust monotonic association with perception scores at the individual-respondent level (Page's L trend test, <i>n</i> = 46, <i>p</i> < 0.001), suggesting that surface behaviour during material removal may contribute to perceived haptic similarity. <b>Conclusions</b>: Matching cutting force alone does not guarantee perceptual equivalence. Among the materials tested, the dental resin composite most closely approximated extracted-enamel surface roughness, received the most favourable and consistent perception scores, and is recommended as the preferred material for pre-clinical typodont fabrication where accessible. These 3D-printed typodonts offer a standardised, openly documented alternative to commercial typodonts for pre-clinical training, with digital models and manufacturing workflows openly available via an institutional platform (TactiTooth).</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentration-Dependent Rheological Properties of Atelocollagen Are Associated with Fibroblast Mechanotransduction and Collagen Remodeling in Aged Skin.","authors":"Seyeon Oh, Gwahn Woo Cheon, Jae Ik Lee, Hyoung Moon Kim, Min Seung Kim, Soo Jeong Heo, Kuk Hui Son, Kyunghee Byun","doi":"10.3390/jfb17090474","DOIUrl":"10.3390/jfb17090474","url":null,"abstract":"<p><p>Injectable collagen biomaterials are used to modify the dermal extracellular matrix in aged skin; however, whether concentration-dependent rheological differences are associated with distinct fibroblast responses remain unclear. We compared 3% and 6% atelocollagen (AtCOL) and examined three mechanobiological programs: (i) integrin (ITG) α5β1-ERK-cyclin D1 signaling related to proliferation; (ii) ITGβ1-FAK-YAP signaling related to matrix synthesis; and (iii) ITGα11β1/Tensin-1-positive fibrillar adhesion related to collagen assembly. Under the tested oscillatory shear conditions, 6% AtCOL displayed higher storage modulus (G'), loss modulus (G″), and complex viscosity, together with a lower tan δ, than 3% AtCOL. In aged mouse skin, the 6% formulation was associated with greater increases in ITGα5, pERK1/2, cyclin D1, PCNA, pFAK, nuclear YAP, COL1A1, COL3A1, ITGα11β1/Tensin-1 co-expression signal, collagen type I/III ratio, collagen type I fiber bundle width, mature collagen content, dermal collagen density, and an instrument-derived skin elasticity index, while MMP1, MMP2, and MMP9 were reduced. In an H₂O₂-induced fibroblast senescence model, ITGβ1 knockdown attenuated AtCOL-associated proliferative, matrix-synthetic, and fibrillar-adhesion responses. Complementary ITGβ1 overexpression produced directionally concordant increases in ITGA11 expression, relative fibroblast proliferation, COL1A1, and COL3A1 and decreases in MMP1, MMP2, and MMP9. Collectively, these findings are consistent with a concentration-dependent, ITGβ1-centered mechanotransduction model linking fibroblast proliferation, matrix synthesis, and collagen assembly within a single AtCOL system.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin (Ferrocene)-Functionalized Polyurethane Composite Dressing Integrated with Dopamine-Grafted Sodium Alginate: Synergistic ROS Modulation and Durable Tissue Adhesion.","authors":"Jiacheng Yu, Chengming Wang, Xiue Ren, Huixia Wang, Yiqiang Huang, Changren Zhou","doi":"10.3390/jfb17090473","DOIUrl":"10.3390/jfb17090473","url":null,"abstract":"<p><p>Elevated levels of reactive oxygen species (ROS) and persistent inflammatory responses represent principal impediments to efficacious wound healing, particularly in mechanically dynamic or infected wound environments. Consequently, multifunctional hydrogel-based dressings capable of integrating coordinated antioxidant, anti-inflammatory, and antimicrobial activities with robust wet-tissue adhesion are highly sought after, yet their development remains limited. Herein, we introduce a curcumin-functionalized polyurethane composite dressing (designated CPFSD), engineered through the incorporation of dopamine-grafted sodium alginate (SD) and ferrocene (Fc), which collectively confer synergistic ROS modulation alongside durable tissue adhesion. Mechanistically, curcumin provides intrinsic antioxidant and anti-inflammatory properties, while Fc facilitates reversible Fe²⁺/Fe³⁺ redox cycling, thereby augmenting ROS scavenging capacity; concurrently, catechol and hydroquinone moieties present on SD establish stable interfacial interactions with moist biological tissues. Comprehensive physicochemical characterization revealed that CPFSD effectively scavenged over 80% of both DPPH and hydroxyl (·OH) radicals, exhibited greater than 80% antibacterial efficacy against Escherichia coli and Staphylococcus aureus, and demonstrated markedly enhanced adhesive performance while preserving mechanical flexibility and cytocompatibility. In vitro assays further indicated that CPFSD significantly attenuated oxidative stress in L929 fibroblasts and RAW264.7 macrophages, accompanied by downregulation of pro-inflammatory cytokine expression. In a murine full-thickness excisional wound model, CPFSD facilitated accelerated epithelialization, angiogenesis, and wound contraction, achieving wound closure at day 11 without observable systemic toxicity. Collectively, these findings underscore that rational multicomponent design strategies can yield adhesion-capable wound dressings endowed with synergistic therapeutic functionalities suitable for addressing complex pathological wound conditions.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"17 9","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13608592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}