Journal of Functional Biomaterials最新文献

{"title":"Biomaterial-Based and Surgical Approaches to Local Hemostasis in Contemporary Oral Surgery: A Narrative Review.","authors":"Atanaska Dinkova, Petko Petrov, Dobromira Shopova, Hristo Daskalov, Stanislava Harizanova","doi":"10.3390/jfb16050190","DOIUrl":"10.3390/jfb16050190","url":null,"abstract":"<p><p>Effective local hemostasis is essential in oral surgery to prevent complications such as delayed healing, infection, and the need for re-intervention. Postoperative bleeding occurs in 4-6% of cases, increasing to 9-12% in patients receiving anticoagulant or antiplatelet therapy. This review evaluates the efficacy, safety, and clinical utility of local hemostatic agents based on 51 studies published between 1990 and 2023. Traditional agents, such as oxidized cellulose and gelatin sponges, control bleeding in over 85% of standard cases but offer limited regenerative benefits. Autologous platelet concentrates (APCs), including platelet-rich plasma (PRP) and leukocyte- and platelet-rich fibrin (L-PRF), reduce bleeding time by 30-50% and enhance soft tissue healing. Studies show the PRP may reduce postoperative bleeding in dental surgery by 30-50%, and in orthopedic and cardiac surgery by 10-30%, particularly in patients on anticoagulants. Tranexamic Acid mouthwash can reduce postoperative bleeding by up to 50-60%. Fibrin sealants achieve a 70-90% reduction in bleeding among high-risk patients, while topical tranexamic acid decreases hemorrhagic events by up to 80% in anticoagulated individuals without increasing thromboembolic risk. However, comparative studies remain limited, particularly in medically compromised populations. Additional gaps persist regarding long-term outcomes, cost-effectiveness, and the standardized use of emerging agents such as nanomaterials. Future research should prioritize high-quality trials across diverse patient groups and develop clinical guidelines that integrate both safety and regenerative outcomes.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Medical Biomaterials for Bone Infections.","authors":"Tianxu Lian, Yiwei Wang, Pengfei Zheng","doi":"10.3390/jfb16050189","DOIUrl":"10.3390/jfb16050189","url":null,"abstract":"<p><p>Bone infection is a debilitating condition characterized by inflammation of the bone and its marrow. It poses significant challenges in clinical practice due to its recalcitrant nature and difficulty in eradicating the infecting microorganisms. Recent advancements in the field of medical biomaterials have shown hope in the treatment of bone infections. This article reviews the research progress of medical biomaterials for anti-osteomyelitis in recent years, focusing on the mechanism of action, unique advantages, and application backgrounds of various materials. At the same time, we pay attention to the need for materials used in the treatment of osteomyelitis to promote bone healing.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12111946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-Strain State Investigation and Ultimate Load on Femoral Implants Based on S-Type Ti6Al4V Titanium Alloy.","authors":"Ivan Panfilov, Ilya Vilkovyskiy, Evgeniy Sadyrin, Sergei Aizikovich, Alexey N Beskopylny, Besarion Meskhi","doi":"10.3390/jfb16050187","DOIUrl":"10.3390/jfb16050187","url":null,"abstract":"<p><p>Hip replacement is a widespread surgical procedure that eliminates pain and restores motor functions of the pathologically altered hip joint. The issue lies in the lack of pre-operative strength calculations for implant shapes. So, they tend to break after surgery or damage the bone due to the complex stress-strain state. In the present paper, we studied the stress-strain state and ultimate load of S-type canine femoral implants based on titanium alloy Ti6Al4V using finite element analysis for static and cyclic loads. X-ray computed micro tomography data were used to construct the models. Re-engineering and restoration of the 3D geometry of the product were conducted. Strength analysis was performed in the finite element analysis software package Ansys Mechanical was used for various types of implant support. Locations with stress concentrators were identified, and ultimate loads on the implant were obtained. The influence of the rigidity of the support on the prosthesis stem was also studied. For the case of rigid support, the stress-strain state of the prosthesis was studied and the ultimate load was found to be 30.1 kg.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12111882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano/Micro-Enabled Modification and Innovation of Conventional Adjuvants for Next-Generation Vaccines.","authors":"Xingchi Liu, Xu Yang, Lu Tao, Xuanchen Li, Guoqiang Chen, Qi Liu","doi":"10.3390/jfb16050185","DOIUrl":"10.3390/jfb16050185","url":null,"abstract":"<p><p>The global spread of infectious diseases has raised public awareness of vaccines, highlighting their essential role in protecting public health. Among the components of modern vaccines, adjuvants have received increasing attention for boosting immune responses and enhancing efficacy. Recent advancements in adjuvant research, particularly nanodelivery systems, have paved the way for developing more effective and safer adjuvants. This review outlines the properties, progress, and mechanisms of FDA-approved conventional adjuvants, focusing on their contributions to and challenges in vaccine success. Despite these advancements, conventional adjuvants still face suboptimal immunomodulatory effects, potential side effects, and limitations in targeting specific immune pathways. Nanodelivery systems have emerged as a transformative approach in adjuvant design, offering unique advantages such as enhancing vaccine stability, enabling controlled antigen release, and inducing specific immune responses. By addressing these limitations, nanocarriers improve the safety and efficacy of conventional adjuvants and drive the development of next-generation adjuvants for complex diseases. This review also explores strategies for incorporating nanodelivery systems into adjuvant development, emphasizing its role in optimizing vaccine formulations. By summarizing current challenges and recent advances, this review aims to provide valuable insights guiding future efforts in designing innovative adjuvants that meet the evolving needs of global immunization programs.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Physical Properties of Calcium Silicate Cement Modified with Elastin-like Polypeptides and Bioactive Glass.","authors":"Jiyoung Kwon, Hyun-Jung Kim","doi":"10.3390/jfb16050188","DOIUrl":"10.3390/jfb16050188","url":null,"abstract":"<p><p>Conventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic-inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP) (V125E8) and bioactive glass (BG) (63S) into CSC to improve its mechanical properties and wash-out resistance during the initial setting. Experimental groups included ProRoot MTA (Dentsply Sirona, USA) as a control (0BG), inorganic hybrids containing BG (2% or 5%; 2BG, 5BG), and organic-inorganic hybrids combining BG (2% or 5%; 2BG-L, 5BG-L) with a 10 wt% ELP solution. The compressive strength, microhardness, and wash-out resistance of the specimens were evaluated. The organic-inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments. The organic-inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12111841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Axis Plate for Open Rigid Internal Fixation of Base Fracture of Mandibular Condyle.","authors":"Marcin Kozakiewicz","doi":"10.3390/jfb16050186","DOIUrl":"10.3390/jfb16050186","url":null,"abstract":"<p><p>Metallic biomaterials are prevalent in medical applications. In the treatment of mandibular fractures, the use of metallic biomaterials makes it possible to recover the ability to bite and partially recover speech through preventing ankylosis of the temporomandibular joints, the formation of pseudoarthritic joints, and the consolidation of reduced bones. This article presents the concept of a triaxial plate for osteosynthesis of basal fractures of the mandibular condyle, which are very common fractures in humans. Approximately half of patients with such fractures have wide (squat) condylar processes, which allows for the use of as many as three straight plates. However, installing three plates is quite troublesome, and the use of a single and transversely reinforced plate would facilitate treatment. This study proposes a plate with three reinforcements running along three divergent axes. The plate is fixed to the bone fragments with 11 screws. This concept for the treatment of basal fractures allows patients to quickly recover their primary system functions due to rigid fixation through the use of short (4 mm) screws, as there is no trauma to the medial pterygoid muscle and the mandible canal contents and no intermaxillary immobilization.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12111821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Literature Review for Total Hip Arthroplasty (THA): Part 2-Material Selection Criteria and Methods.","authors":"Salvatore Garofalo, Chiara Morano, Luigi Bruno, Leonardo Pagnotta","doi":"10.3390/jfb16050184","DOIUrl":"10.3390/jfb16050184","url":null,"abstract":"<p><p>Total Hip Arthroplasty (THA) is a widely used surgical procedure to restore mobility and reduce pain in patients with hip joint disorders. Implant success and longevity are influenced by the selection of appropriate materials. This study presents a comprehensive literature review based on structured searches in Scopus and Web of Science, focusing on material selection criteria and methods in THA. The inclusion criteria targeted original studies and reviews addressing material properties, selection techniques, and clinical performance. A bibliometric analysis and keyword co-occurrence network were used to highlight major research themes. The review examines traditional materials such as Metal-on-Polyethylene (MoP), as well as advanced options like ceramics, composites, and Functionally Graded Materials (FGMs). Key challenges discussed include aseptic loosening, wear resistance, and stress shielding. Selection methodologies such as Multi-Criteria Decision-Making (MCDM), Weighted Properties Methods (WPM), and computational tools like Ashby charts and CES Selector are analyzed. The findings from international arthroplasty registries show that more than half of implant failures are linked to material-related factors. This study therefore aims to guide material selection processes in THA by aligning clinical performance with biomechanical and biological requirements, supporting improved implant outcomes and long-term surgical success. Future developments should focus on patient-specific solutions and continuous innovation.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity.","authors":"Celine Guder, Anja Hofmann, Therese Schüler, Torsten Sterzenbach, Hans-Peter Wiesmann, Katrin Lorenz, Christian Hannig, Christian Reeps, Benjamin Kruppke","doi":"10.3390/jfb16050182","DOIUrl":"10.3390/jfb16050182","url":null,"abstract":"<p><p>Common antibiotic therapies to treat bacterial infections are associated with systemic side effects and the development of resistance, directly connected to duration and dosage. Local drug delivery systems (DDSs) offer an alternative by localising antibiotics and thereby limiting their side effects while reducing the dosage necessary. A biodegradable polyester polycaprolactone (PCL)-based DDS was thus produced, containing various clinically relevant drugs. It was shown that the incorporation of four distinct antibiotic classes (amoxicillin, doxycycline, metronidazole and rifampicin), with very high mass fractions ranging up to 20 wt%, was feasible within the PCL matrix. This DDS showed the capacity for effective and sustained release. The release kinetics over 14 days were proven, showing a significant decrease in cytotoxicity with smooth muscle cells as well as an antibacterial effect on (1) aerobic, (2) anaerobic, (3) Gram-positive and (4) Gram-negative pathogens in vitro. The DDS demonstrated a markedly diminished cytotoxic impact owing to sustained release in comparison to pure antibiotics, while simultaneously maintaining their antibacterial efficacy. In conclusion, DDSs are a more tolerable form of antibiotics administration due to the hydrophobic PCL matrix causing a slower diffusion-controlled release, proven as a release mechanism via the Peppa-Sahlin model.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12111853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Analysis of Lithium Disilicate Ceramics After Use of Charcoal-Containing Toothpastes.","authors":"Franciele Floriani, Bayaan Jabr, Silvia Rojas-Rueda, Rene Garcia-Contreras, Carlos A Jurado, Abdulrahman Alshabib","doi":"10.3390/jfb16050183","DOIUrl":"10.3390/jfb16050183","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the effect of charcoal-containing toothpaste on the surface roughness of CAD/CAM lithium disilicate ceramic (e.max CAD) after simulated toothbrushing.</p><p><strong>Methods: </strong>Forty-eight e.max CAD ceramic specimens were divided into four groups (n = 12) and subjected to 18,000 brushing cycles using a toothbrushing simulator. The groups included Crest 3D White Charcoal, Colgate Optic White with Charcoal, Arm & Hammer Charcoal White, and a control group (conventional toothpaste). Surface roughness was measured with a profilometer before and after brushing, and scanning electron microscopy (SEM) was used for topographical analysis. Statistical analysis was performed using the Kruskal-Wallis test and post hoc comparisons.</p><p><strong>Results: </strong>Significant differences in surface roughness were found among the groups (<i>p</i> < 0.001). The mean roughness values were 540.70 ± 21.68 µm (Control), 294.88 ± 11.49 µm (Crest 3D White Charcoal), 1157.00 ± 52.85 µm (Colgate Optic White with Charcoal), and 593.37 ± 37.69 µm (Arm & Hammer Charcoal White). Post hoc analysis showed that Colgate Optic White with Charcoal had the highest roughness, which was significantly different from all other groups (<i>p</i> < 0.001). SEM analysis revealed severe surface degradation with Colgate Optic White with Charcoal, while Crest 3D White Charcoal caused minimal changes.</p><p><strong>Conclusions: </strong>Charcoal-containing toothpastes vary in abrasiveness, with Colgate Optic White with Charcoal causing the most significant surface roughness and damage to lithium disilicate ceramics.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Physicochemical and Mechanical Properties of a Modified Adhesive System by Resveratrol Incorporation.","authors":"Amanda Guedes Nogueira Matuda, Karen Cristina Kazue Yui, Nathália Moreira Gomes, Gabriela da Silva Chagas, Marcella Batista Rocha, Fernanda Labiapari Senefonte, Mariane Cintra Mailart, Cesar Rogério Pucci","doi":"10.3390/jfb16050178","DOIUrl":"10.3390/jfb16050178","url":null,"abstract":"<p><p>This study aimed to evaluate the physicochemical and mechanical properties of a modified adhesive system containing resveratrol by assessing its microtensile bond strength (µTBS), degree of conversion (DC), mini-flexural strength (MFS), and antibacterial activity. The modified etch-and-rinse adhesive system was prepared by resveratrol (RES) incorporation in different concentrations: adhesive with 0.5% RES (RES0.5), adhesive with 1% RES (RES1), adhesive with 2% RES (RES2), and adhesive with no RES incorporation (RES0-control group). The µTBS test was conducted on 40 human molars with dentin exposure, which were etched, bonded with the adhesives (<i>n</i> = 10), and restored with resin composite. Fourier Transform Infrared Spectroscopy (FTIR) measured the DC for the MFS; ten adhesive sticks were made for each group. Antibacterial activity was assessed using colony-forming unit (CFU) counts. For µTBS, no difference between the groups was found (mean ± SD): RES0.5-42.93 ± 15.49^A; RES1-42.61 ± 13.97^A and RES2-39.43 ± 9.14^A; RES0-41.01 ± 2.64^A. The DC (% ± SD) of the experimental groups was similar: RES0.5-81.02 ± 1.95^A; RES1-76.02 ± 9.00^A; RES2-58.86 ± 15.94^A; RES0-77.75 ± 3.22^A. For MFS (mean ± SD): RES0.5-33.14 ± 13.83^A; RES1-31.1 ± 12.21^A; RES2-19.72 ± 5.43^B; RES0-29.72 ± 11.95^A. For CFU (mean ± SD): RES0.5-0.67 × 10⁷ ± 0.37^B; RES1-0.68 × 10⁷ ± 0.34^B; RES2-0.60 × 10⁷ ± 0.02^C; RES0-0.75 × 10⁷ ± 0.03^A. The incorporation of resveratrol into the adhesive system at low concentrations (0.5 and 1%) does not alter the bond strength of the adhesive interface, the degree of conversion, or the flexural strength. Additionally, both concentrations exhibited antibacterial properties by reducing the colony-forming units of <i>S. mutans</i>.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}