Bio-Functional Nanomaterials for Enhanced Lung Cancer Therapy: The Synergistic Roles of Vitamins D and K.

IF 5.2 3区 医学 Q1 ENGINEERING, BIOMEDICAL
Andreea Crintea, Camelia Munteanu, Tamás Ilyés, Ciprian N Silaghi, Alexandra M Crăciun
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引用次数: 0

Abstract

Lung cancer remains a leading cause of cancer-related mortality worldwide, requiring the development of innovative and effective therapeutic strategies. Bio-functional nanomaterials, due to their unique physicochemical properties, offer a versatile platform for targeted drug delivery, controlled release, and multimodal therapies, thereby enhancing efficacy and reducing the systemic toxicity of conventional treatments. Independently, both vitamin D and vitamin K have demonstrated significant anti-cancer properties, including inhibition of proliferation, induction of apoptosis, modulation of angiogenesis, and attenuation of metastatic potential in various cancer cell lines and in vivo models. However, their clinical application is often limited by poor bioavailability, rapid metabolism, and potential for off-target effects. Specifically, by enhancing the solubility, stability, and targeted accumulation of fat-soluble vitamins D and K within tumoral tissues for improved lung cancer therapy, this review emphasizes the novel and cooperative role of bio-functional nanomaterials in overcoming these limitations. Future studies should focus on the logical development of sophisticated nanomaterial carriers for optimal co-delivery plans and thorough in vivo validation, aiming to convert these encouraging preclinical results into successful clinical treatments for patients with lung cancer.

增强肺癌治疗的生物功能纳米材料:维生素D和K的协同作用。
肺癌仍然是全球癌症相关死亡的主要原因,需要开发创新和有效的治疗策略。生物功能纳米材料由于其独特的物理化学特性,为靶向药物递送、控释和多模式治疗提供了一个通用的平台,从而提高了常规治疗的疗效并降低了全身毒性。单独来看,维生素D和维生素K都显示出显著的抗癌特性,包括在各种癌细胞系和体内模型中抑制增殖、诱导细胞凋亡、调节血管生成和降低转移潜能。然而,它们的临床应用往往受到生物利用度差、代谢快和潜在脱靶效应的限制。具体来说,通过提高脂溶性维生素D和K在肿瘤组织中的溶解度、稳定性和靶向积累来改善肺癌治疗,本综述强调了生物功能纳米材料在克服这些局限性方面的新颖和协同作用。未来的研究应侧重于复杂纳米材料载体的逻辑开发,以实现最佳的共递送计划和彻底的体内验证,旨在将这些令人鼓舞的临床前结果转化为肺癌患者的成功临床治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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