基于静电排斥和疏水相互作用的抗膨胀抗菌水凝胶用于人体运动传感。

IF 5.2 3区 医学 Q1 ENGINEERING, BIOMEDICAL
Zexing Deng, Litong Shen, Qiwei Cheng, Ying Li, Tianming Du, Xin Zhao
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引用次数: 0

摘要

高性能传感材料的开发对生物电子学的发展至关重要。导电水凝胶具有独特的柔韧性,是生物医学传感器的有希望的候选者。然而,传统的导电水凝胶往往遭受过度膨胀和不良的抗菌活性,限制了它们的实际应用。为了克服这些挑战,通过自由基聚合构建了抗膨胀、抗菌和离子导电的水凝胶。采用由丙烯酸(AA)、抗菌两性离子化合物[2-(甲基丙烯氧基)乙基]二甲基-(3-磺丙基)氢氧化铵(SBMA)和疏水单体甲基丙烯酸十二酯(LMA)组成的单体混合物进行制备。SBMA被AA质子化,使静电排斥,从而赋予水凝胶抗膨胀性能。疏水LMA组分的引入进一步提高了水凝胶的抗膨胀性能和力学性能。制备的水凝胶具有良好的抗膨胀性能,120 h后溶胀率为59.36%,力学性能良好,抗拉强度为158 kPa,断裂伸长率为176%,80%应变时抗压强度为0.37 MPa。此外,水凝胶具有优异的应变传感性能,在应变的40-60%范围内,测量因子为1.315,响应时间为330 ms,恢复时间为177 ms。此外,水凝胶能够监测人体运动和生理信号。这些特性使其非常适合可穿戴传感器和生物医学监测应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-Swelling Antibacterial Hydrogels Based on Electrostatic Repulsion and Hydrophobic Interactions for Human Motion Sensing.

The development of high-performance sensing materials is critical for advancing bioelectronics. Conductive hydrogels, with their unique flexibility, are promising candidates for biomedical sensors. However, traditional conductive hydrogels often suffer from excessive swelling and undesirable antibacterial activity, limiting their practical use. To overcome these challenges, anti-swelling, antibacterial, and ionically conductive hydrogels were built through free radical polymerization. The preparation was conducted using a monomer mixture comprising acrylic acid (AA), the antibacterial zwitterionic compound [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), and the hydrophobic monomer lauryl methacrylate (LMA). The protonation of SBMA by AA enables electrostatic repulsion, thereby imparting anti-swelling properties to the hydrogel. The introduction of hydrophobic LMA components further enhances the anti-swelling and mechanical performance of hydrogel. The resulting hydrogel exhibits excellent anti-swelling property with a swelling ratio of 59.36% after 120 h and good mechanical performance with a tensile strength of 158 kPa, an elongation at break of 176%, and a compressive strength of 0.37 MPa at 80% strain. In addition, hydrogels possess superior sensing performance for strain sensing with a gauge factor of 1.315 within 40-60% of strain, 330 ms of response time, and 177 ms of recovery time. Furthermore, the hydrogel is capable of monitoring human motion and physiological signals. These attributes make it highly suitable for wearable sensors and biomedical monitoring applications.

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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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