Journal of Functional Biomaterials最新文献_第10页

Enhancing the Biological Properties of Organic-Inorganic Hybrid Calcium Silicate Cements: An In Vitro Study. 增强有机-无机混合硅酸钙水泥的生物特性：体外研究。

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-10 DOI: 10.3390/jfb15110337

Minji Choi, Jiyoung Kwon, Ji-Hyun Jang, Duck-Su Kim, Hyun-Jung Kim

{"title":"Enhancing the Biological Properties of Organic-Inorganic Hybrid Calcium Silicate Cements: An In Vitro Study.","authors":"Minji Choi, Jiyoung Kwon, Ji-Hyun Jang, Duck-Su Kim, Hyun-Jung Kim","doi":"10.3390/jfb15110337","DOIUrl":"10.3390/jfb15110337","url":null,"abstract":"(1) Background: This study aimed to enhance the biological properties of hydraulic calcium silicate cements (HCSCs) by incorporating organic and inorganic components, specifically elastin-like polypeptides (ELPs) and bioactive glass (BAG). We focused on the effects of these composites on the viability, migration, and osteogenic differentiation of human periodontal ligament fibroblasts (hPDLFs). (2) Methods: Proroot MTA was supplemented with 1-5 wt% 63S BAG and 10 wt% ELP. The experimental groups contained various combinations of HSCS with ELP and BAG. Cell viability was assessed using an MTT assay, cell migration was evaluated using wound healing and transwell assays, and osteogenic activity was determined through Alizarin Red S staining and a gene expression analysis of osteogenic markers (ALP, RUNX-2, OCN, and Col1A2). (3) Results: The combination of ELP and BAG significantly enhanced the viability of hPDLFs with an optimal BAG concentration of 1-4%. Cell migration assays demonstrated faster migration rates in groups with 2-4% BAG and ELP incorporation. Osteogenic activity was the highest with 2-3% BAG incorporation with ELP, as evidenced by intense Alizarin Red S staining and the upregulation of osteogenic differentiation markers. (4) Conclusions: The incorporation of ELP (organic) and BAG (inorganic) into HCSC significantly enhances the viability, migration, and osteogenic differentiation of hPDLFs. These findings suggest that composite HCSC might support healing in destructed bone lesions in endodontics.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Adult-Acquired Flatfoot Deformity Treatment: Enhanced Biomechanical Support Through Graphene Oxide-Integrated Bioengineered Grafts Tested In Silico. 推进成人获得性扁平足畸形治疗：通过氧化石墨烯集成生物工程移植物增强生物力学支持的硅学测试。

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-09 DOI: 10.3390/jfb15110335

Sebastián Nieto, Mónica Gantiva-Díaz, María A Hoyos, Yuliet Montoya, Juan C Cruz, Christian Cifuentes-De la Portilla

{"title":"Advancing Adult-Acquired Flatfoot Deformity Treatment: Enhanced Biomechanical Support Through Graphene Oxide-Integrated Bioengineered Grafts Tested In Silico.","authors":"Sebastián Nieto, Mónica Gantiva-Díaz, María A Hoyos, Yuliet Montoya, Juan C Cruz, Christian Cifuentes-De la Portilla","doi":"10.3390/jfb15110335","DOIUrl":"10.3390/jfb15110335","url":null,"abstract":"Adult-Acquired Flatfoot Deformity (AAFD) is a progressive orthopedic condition causing the collapse of the foot's medial longitudinal arch, often linked with injuries to the plantar arch's passive stabilizers, such as the spring ligament (SL) and plantar fascia. Conventional treatment typically involves replacing the SL with synthetic material grafts, which, while providing mechanical support, lack the biological compatibility of native ligaments. In response to this shortcoming, our study developed an electrospun, twisted polymeric graft made of polycaprolactone (PCL) and type B gelatin (GT), enhanced with graphene oxide (GO), a two-dimensional nanomaterial, to bolster biomechanical attributes. The addition of GO aimed to match the native ligamentous tissue's mechanical strength, with the PCL-GT-GO 2.0% blend demonstrating an optimal Young's modulus of 240.75 MPa. Furthermore, the graft showcased excellent biocompatibility, evidenced by non-hemolytic reactions, suitable wettability and favorable platelet aggregation-essential features for promoting cell adhesion and proliferation. An MTT assay revealed cell viability exceeding 80% after 48 h of exposure, highlighting the potential of the graft as a regenerative scaffold for affected ligaments. Computational modeling of the human foot across various AAFD stages assessed the graft's in situ performance, with the PCL-GT-OG 2.0% graft efficiently preventing plantar arch collapse and offering hindfoot pronator support. Our study, based on in silico simulations, suggests that this bioengineered graft holds significant promise as an alternative treatment in AAFD surgery, marking a leap forward in the integration of advanced materials science for enhanced patient care.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects-A Prospective, Comparative Clinical Study. 富含生长因子的血浆与 Xenogenic 骨移植治疗牙周骨内缺损的前瞻性比较临床研究。

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-09 DOI: 10.3390/jfb15110336

Sourav Panda, Sital Panda, Abhaya Chandra Das, Natalia Lewkowicz, Barbara Lapinska, Margherita Tumedei, Funda Goker, Niccolò Cenzato, Massimo Del Fabbro

{"title":"Plasma Rich in Growth Factors Compared to Xenogenic Bone Graft in Treatment of Periodontal Intra-Osseous Defects-A Prospective, Comparative Clinical Study.","authors":"Sourav Panda, Sital Panda, Abhaya Chandra Das, Natalia Lewkowicz, Barbara Lapinska, Margherita Tumedei, Funda Goker, Niccolò Cenzato, Massimo Del Fabbro","doi":"10.3390/jfb15110336","DOIUrl":"10.3390/jfb15110336","url":null,"abstract":"Background: Periodontal intra-bony defects are challenging conditions in dental practice, often requiring regenerative approaches for successful treatment. This clinical study aimed to compare the effectiveness of plasma rich in growth factors (PRGF) versus xenogenic bone graft (BXG) in addressing intra-bony defects.Methods: Forty patients aged between 30 and 50 years presenting with generalized periodontitis were included. The study assessed various parameters, including relative attachment level (RAL); probing pocket depth (PPD); gingival marginal level (GML); intra-bony defect depth (IBDD) at baseline, 3, and 6 months; and level of pain, post-operative bleeding, and swelling, as patient-reported outcomes during the first seven days post operation.Results: The results revealed that both PRGF and BXG treatments led to significant reductions in IBDD over the 6-month study period. PRGF demonstrated significant advantages in GML enhancement and post-operative pain management during the initial post-treatment days. However, BXG showed a significantly greater reduction in IBDD compared to PRGF. Post-operative bleeding and swelling levels were comparable between the two treatments.Conclusions: These findings underscore the efficacy of both PRGF and BXG in periodontal regeneration, with treatment decisions guided by patient-specific factors and clinical goals.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Plaque Accumulation Between Titanium and PEEK Healing Abutments. 钛基台与 PEEK 愈合基台牙菌斑累积情况的比较

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-07 DOI: 10.3390/jfb15110334

Suphachai Suphangul, Patr Pujarern, Dinesh Rokaya, Chatruethai Kanchanasobhana, Pimduen Rungsiyakull, Pisaisit Chaijareenont

{"title":"Comparison of Plaque Accumulation Between Titanium and PEEK Healing Abutments.","authors":"Suphachai Suphangul, Patr Pujarern, Dinesh Rokaya, Chatruethai Kanchanasobhana, Pimduen Rungsiyakull, Pisaisit Chaijareenont","doi":"10.3390/jfb15110334","DOIUrl":"10.3390/jfb15110334","url":null,"abstract":"Titanium (Ti) is considered the gold standard material for provisional implant restorations. Polyetheretherketone (PEEK), a polymeric thermoplastic material, has been progressively used in prosthetic, restorative, and implant dentistry. Recently, PEEK has been used in implant dentistry as a provisional implant restoration. Plaque accumulation and biofilm formation become the major concerns when infection and inflammation occur in the peri-implant tissue. Few reports were studied regarding the biofilm formation on the PEEK surface. This study aimed to compare plaque accumulation between the PEEK and Ti healing abutments. In an in vitro setting, the Ti healing abutment and PEEK healing abutment were subjected to biofilm formation; the result was collected after 24 h, 48 h, 72 h, and 7 days. Biofilms were studied following staining with crystal violet. The data were analyzed by Two-Way ANOVA. It was found that between Ti healing abutment and PEEK healing abutment materials, the biofilm formation on the PEEK surface is slightly higher than Ti, but no statistical difference (p > 0.05) was found. The results suggested that plaque accumulation between the Ti healing abutment and the PEEK healing abutment was not different. We concluded that the plaque accumulation on the surface PEEK healing abutment was similar to the conventional Ti healing abutment materials. Hence, both the PEEK and Ti healing abutments can be used as a healing abutment biomaterial according to the requirements of the prostheses in implant dentistry.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Infrared Light Photodynamic Therapy with PEI-Capped Up-Conversion Nanoparticles and Chlorin e6 Induces Apoptosis of Oral Cancer Cells. 用 PEI 封端上转换纳米粒子和氯素 e6 进行近红外光光动力疗法可诱导口腔癌细胞凋亡

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-07 DOI: 10.3390/jfb15110333

Jinhao Cui, Yoshimasa Makita, Tomoharu Okamura, Chihoko Ikeda, Shin-Ichi Fujiwara, Kazuya Tominaga

{"title":"Near-Infrared Light Photodynamic Therapy with PEI-Capped Up-Conversion Nanoparticles and Chlorin e6 Induces Apoptosis of Oral Cancer Cells.","authors":"Jinhao Cui, Yoshimasa Makita, Tomoharu Okamura, Chihoko Ikeda, Shin-Ichi Fujiwara, Kazuya Tominaga","doi":"10.3390/jfb15110333","DOIUrl":"10.3390/jfb15110333","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is a common malignancy in the oral cavity. Photodynamic therapy (PDT) is a new alternative for the treatment of diseases using photosensitizers (PS) and light. In this study, we used a photosensitizer complex (Ce6-MnNPs-Chlorin e6 combined with up-conversion nanoparticles NaYF4:Yb/Er/Mn) to investigate the therapeutic effectiveness of this treatment against oral cancer cells. We also investigated the mechanism of action of near-infrared light PDT (NIR-PDT) combined with the Ce6-MnNPs. After determining a suitable concentration of Ce6-MnNPs using an MTT assay, human oral squamous cell carcinoma cells (HSC-3) were treated with NIR-PDT with Ce6-MnNPs. We examined the characteristics of Ce6-MnNPs by transmission electron microscopy (TEM); a zeta potential and particle size analyzer; Fourier-transform infrared spectroscopy (FTIR); cell viability by MTT assay; and apoptosis by FITC-Annexin V/PI assay. The mitochondrial membrane potential (MMP), apoptosis-related mRNA level (Bax and Bcl-2) and p53 protein were also researched. NIR-PDT with 0.5 ng/µL Ce6-MnNPs inhibited the proliferation of HSC-3 (p < 0.05). After treatment with NIR-PDT, changes in the mitochondrial membrane potential and apoptosis occurred (p < 0.01). The ratio of Bax/Bcl-2 and p53-positive cells increased (p < 0.01). These results suggest that this treatment can induce apoptosis of oral cancer cells.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Compounds Enhance the Biocompatibility and the Physical Properties of a Glass Ionomer Cement. 生物活性化合物增强了玻璃离子黏合剂的生物相容性和物理性能。

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-07 DOI: 10.3390/jfb15110332

Aline Rogéria Freire de Castilho, Pedro Luiz Rosalen, Marina Yasbeck Oliveira, Jonny Burga-Sánchez, Simone Duarte, Ramiro Mendonça Murata, Regina Maria Puppin Rontani

{"title":"Bioactive Compounds Enhance the Biocompatibility and the Physical Properties of a Glass Ionomer Cement.","authors":"Aline Rogéria Freire de Castilho, Pedro Luiz Rosalen, Marina Yasbeck Oliveira, Jonny Burga-Sánchez, Simone Duarte, Ramiro Mendonça Murata, Regina Maria Puppin Rontani","doi":"10.3390/jfb15110332","DOIUrl":"10.3390/jfb15110332","url":null,"abstract":"In order to characterize a novel restorative material, knowledge about the toxicological effect on human cells and the physical behavior of a glass ionomer cement (GIC) containing flavonoids was established. The flavonoids apigenin, naringenin, quercetin, and liquiritigenin were manually incorporated into a GIC. In the control group, no incorporation was performed. Two cell culture assays evaluated the toxicity of GICs: SRB and MTT. For both assays, the keratinocyte cell line (HaCaT) was exposed to GIC (n = 3/group) for 24 h. The physical properties of the GICs were evaluated by compressive strength (n = 10), surface roughness (n = 10), and hardness (n = 10) tests. Cell viability by SRB ranged from 103% to 97%. The control revealed a significant decrease in the metabolism of cells (61%) by MTT, while the GIC+apigenin slightly increased the succinic dehydrogenase activity (105%; p > 0.05), also confirmed microscopically. The compressive strength and roughness values were similar among groups, but the hardness increased after the incorporation of naringenin and quercetin into GIC (p < 0.05). The incorporation of flavonoids positively altered the biological and physical properties of the GICs.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Bone Regeneration with Demineralized Dentin-Derived Graft Material: Impact of Demineralization Duration in a Rabbit Calvaria Model. 用脱矿牙本质移植材料优化骨再生：兔钙化模型中脱矿时间的影响

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-06 DOI: 10.3390/jfb15110331

Bounghoon Lee, Hyunsuk Choi, Dong-Seok Sohn

引用次数: 0

Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models. 三维口腔黏膜模型中的交界上皮生物工程

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-06 DOI: 10.3390/jfb15110330

Marianna Gavriiloglou, Mira Hammad, Jordan M Iliopoulos, Pierre Layrolle, Danae A Apazidou

{"title":"Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models.","authors":"Marianna Gavriiloglou, Mira Hammad, Jordan M Iliopoulos, Pierre Layrolle, Danae A Apazidou","doi":"10.3390/jfb15110330","DOIUrl":"10.3390/jfb15110330","url":null,"abstract":"Two-dimensional (2D) culture models and animal experiments have been widely used to study the pathogenesis of periodontal and peri-implant diseases and to test new treatment approaches. However, neither of them can reproduce the complexity of human periodontal tissues, making the development of a successful 3D oral mucosal model a necessity. The soft-tissue attachment formed around a tooth or an implant function like a biologic seal, protecting the deeper tissues from bacterial infection. The aim of this review is to explore the advancements made so far in the biofabrication of a junctional epithelium around a tooth-like or an implant insert in vitro. This review focuses on the origin of cells and the variety of extracellular components and biomaterials that have been used for the biofabrication of 3D oral mucosa models. The existing 3D models recapitulate soft-tissue attachment around implant abutments and hydroxyapatite discs. Hereby, the qualitative and quantitative assessments performed for evidencing the soft-tissue attachment are critically reviewed. In perspective, the design of sophisticated 3D models should work together for oral immunology and microbiology biofilms to accurately reproduce periodontal and peri-implant diseases.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Nanocomposite Microspheres for Nasal Administration of Deferiprone in Neurodegenerative Disorders. 开发用于神经退行性疾病的去铁酮鼻腔给药纳米复合微球

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-05 DOI: 10.3390/jfb15110329

Radka Boyuklieva, Plamen Katsarov, Plamen Zagorchev, Silviya Abarova, Asya Hristozova, Bissera Pilicheva

{"title":"Development of Nanocomposite Microspheres for Nasal Administration of Deferiprone in Neurodegenerative Disorders.","authors":"Radka Boyuklieva, Plamen Katsarov, Plamen Zagorchev, Silviya Abarova, Asya Hristozova, Bissera Pilicheva","doi":"10.3390/jfb15110329","DOIUrl":"10.3390/jfb15110329","url":null,"abstract":"Elevated brain iron levels are characteristic of many neurodegenerative diseases. As an iron chelator with short biological half-life, deferiprone leads to agranulocytosis and neutropenia with a prolonged therapeutic course. Its inclusion in sustained-release dosage forms may reduce the frequency of administration. On the other hand, when administered by an alternative route of administration, such as the nasal route, systemic exposure to deferiprone will be reduced, thereby reducing the occurrence of adverse effects. Direct nose-to-brain delivery has been raised as a non-invasive strategy to deliver drugs to the brain, bypassing the blood-brain barrier. The aim of the study was to develop and characterize nanocomposite microspheres suitable for intranasal administration by combining nano- and microparticle-based approaches. Nanoparticles with an average particle size of 213 ± 56 nm based on the biodegradable polymer poly-ε-caprolactone were developed using the solvent evaporation method. To ensure the deposition of the particles in the nasal cavity and avoid exhalation or deposition into the small airways, the nanoparticles were incorporated into composite structures of sodium alginate obtained by spray drying. Deferiprone demonstrated sustained release from the nanocomposite microspheres and high iron-chelating activity.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats. 用染料木素对去蛋白牛骨进行声化处理，可增强卵巢切除大鼠植骨期骨缺损的骨修复。

IF 5 3区医学

Journal of Functional Biomaterials Pub Date : 2024-11-05 DOI: 10.3390/jfb15110328

Nathália Dantas Duarte, Gabriel Mulinari-Santos, Fábio Roberto de Souza Batista, Marcelly Braga Gomes, Naara Gabriela Monteiro, Ana Cláudia Ervolino da Silva, Reinhard Gruber, Paulo Noronha Lisboa-Filho, Pedro Henrique Silva Gomes-Ferreira, Roberta Okamoto

{"title":"Sonification of Deproteinized Bovine Bone Functionalized with Genistein Enhances Bone Repair in Peri-Implant Bone Defects in Ovariectomized Rats.","authors":"Nathália Dantas Duarte, Gabriel Mulinari-Santos, Fábio Roberto de Souza Batista, Marcelly Braga Gomes, Naara Gabriela Monteiro, Ana Cláudia Ervolino da Silva, Reinhard Gruber, Paulo Noronha Lisboa-Filho, Pedro Henrique Silva Gomes-Ferreira, Roberta Okamoto","doi":"10.3390/jfb15110328","DOIUrl":"10.3390/jfb15110328","url":null,"abstract":"Estrogen deficiency is one of several contributing factors to catabolic changes in bone surrounding dental implants, impairing bone repair in defects requiring bone regeneration. Functionalizing bone substitutes is an alternative approach among various strategies to address this challenge. In this study, the aim was to evaluate the effect of functionalizing deproteinized bovine bone (Bio-Oss®, BO) with genistein via sonication on peri-implant bone defects in ovariectomized rats. The animals were randomly distributed according to the treatment into the following four groups (n = 10): BO sonicated with genistein (BOS + GEN), BO sonicated alone (BOS), untreated BO (BO), and blood clot only (CLOT). After twenty-eight days, implant removal torque was determined, and the peri-implant bone parameters were calculated based on computed microtomography. Additionally, the gene expression of bone turnover markers was evaluated. As a main result, the functionalization with genistein increased implant removal torque and the peri-implant bone volume in the BOS + GEN group compared to both BOS and BO groups (both p < 0.05). These findings suggest that the sonification of deproteinized bovine bone functionalized with genistein improves bone repair in peri-implant bone defects in ovariectomized rats.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 11","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0