Journal of Functional Biomaterials最新文献_第10页

In-Vitro Assessment of Artificial Tooth Material Wear Behavior Using 3D Wear Analysis. 利用三维磨损分析体外评估人工牙材料磨损行为。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-16 DOI: 10.3390/jfb16070264

Sıla Yelekçi, Ayben Şentürk, Funda Akaltan

{"title":"In-Vitro Assessment of Artificial Tooth Material Wear Behavior Using 3D Wear Analysis.","authors":"Sıla Yelekçi, Ayben Şentürk, Funda Akaltan","doi":"10.3390/jfb16070264","DOIUrl":"10.3390/jfb16070264","url":null,"abstract":"Background: Artificial tooth wear impacts prosthesis durability and function; understanding material-antagonist interactions guides clinical choices.Aim: This in-vitro study aimed to assess the wear behavior of isosit and nanohybrid composite resin artificial teeth when opposed to various antagonist materials using 3D volumetric wear analysis.Materials and methods: Sixty specimens (n = 10 per group) were prepared from two artificial tooth materials and assigned to six antagonist combinations: isosit-isosit, isosit-nanohybrid composite, isosit-porcelain, nanohybrid composite-isosit, nanohybrid composite-nanohybrid composite, and nanohybrid composite-porcelain. Specimens were scanned before and after 600,000 chewing cycles using a structured-light 3D scanner. Volumetric wear was calculated by superimposing pre- and post-test scans. Data were analyzed using two-way ANOVA and Tukey's HSD test (α = 0.05).Results: Porcelain antagonists produced the highest wear values (p < 0.05). No significant difference was found between isosit and nanohybrid antagonists (p > 0.05). Identical material pairings showed less wear, though differences were not statistically significant.Conclusions: Porcelain as an antagonist increased wear risk. Using identical materials bilaterally, such as isosit-isosit or nanohybrid-nanohybrid, may help reduce artificial tooth wear in removable prostheses.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propolis as an Adjunct in Non-Surgical Periodontal Therapy: Current Clinical Perspectives from a Narrative Review. 蜂胶作为非手术牙周治疗的辅助剂：从叙述回顾的当前临床观点。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-16 DOI: 10.3390/jfb16070265

Vitolante Pezzella, Alessandro Cuozzo, Leopoldo Mauriello, Alessandro Polizzi, Vincenzo Iorio Siciliano, Luca Ramaglia, Andrea Blasi

{"title":"Propolis as an Adjunct in Non-Surgical Periodontal Therapy: Current Clinical Perspectives from a Narrative Review.","authors":"Vitolante Pezzella, Alessandro Cuozzo, Leopoldo Mauriello, Alessandro Polizzi, Vincenzo Iorio Siciliano, Luca Ramaglia, Andrea Blasi","doi":"10.3390/jfb16070265","DOIUrl":"10.3390/jfb16070265","url":null,"abstract":"Non-surgical periodontal therapy (NSPT) represents the gold standard in the treatment of periodontitis, but deep periodontal pockets and complex anatomies may reduce its efficacy. Therefore, in order to enhance NSPT outcomes and reduce the need for surgical intervention, several adjunctive therapies have been proposed. Propolis, a natural substance with antimicrobial, anti-inflammatory, and healing properties, has shown promising results in controlling supragingival biofilm. This narrative review aims to assess the clinical efficacy of propolis as an adjunct to NSPT. A comprehensive search on scientific databases was conducted for randomised clinical trials (RCTs) comparing NSPT with and without propolis, or with other adjuncts or placebos. Probing depth (PD) was the primary outcome. Seven RCTs met the inclusion criteria, using different propolis formulations and application protocols. Statistically significant improvements in clinical outcomes were recorded in all analysed studies compared with NSPT alone or placebo, while benefits were less substantial compared with laser therapy and conflicting when compared with chlorhexidine. Thus propolis may be considered a promising adjunctive agent to NSPT, with the potential to improve clinical outcomes of NSPT. Nonetheless, further long-term clinical trials with larger sample size are needed to validate its clinical efficacy and to determine its adverse effects.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Different Surface Treatments and Accelerated Aging on Dental Zirconia-An In Vitro Study. 不同表面处理及加速老化对牙体氧化锆的影响-体外研究

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-16 DOI: 10.3390/jfb16070263

Mihaela Pantea, Lucian Toma Ciocan, Vlad Gabriel Vasilescu, Georgeta Voicu, Adrian-Ionut Nicoară, Florin Miculescu, Robert Ciocoiu, Ana Maria Cristina Țâncu, Elena Georgiana Banu, Marina Imre

{"title":"Effects of Different Surface Treatments and Accelerated Aging on Dental Zirconia-An In Vitro Study.","authors":"Mihaela Pantea, Lucian Toma Ciocan, Vlad Gabriel Vasilescu, Georgeta Voicu, Adrian-Ionut Nicoară, Florin Miculescu, Robert Ciocoiu, Ana Maria Cristina Țâncu, Elena Georgiana Banu, Marina Imre","doi":"10.3390/jfb16070263","DOIUrl":"10.3390/jfb16070263","url":null,"abstract":"This in vitro study aimed to compare the effects of various surface treatments and hydrothermal aging on the phase composition, microstructure, and compressive strength of dental zirconia (ZrO2). Forty-eight zirconia cubes (8 × 8 × 8 mm) were fabricated using CAD/CAM from two materials: infrastructure zirconia (Group S1) and super-translucent multilayered monolithic zirconia (Group S2). Four samples of each material were analyzed in their pre-sintered state (S1-0, S2-0). The remaining specimens were sintered and assigned to sub-groups based on surface treatment: untreated, sandblasted with 30 µm or 50 µm Al2O3, polished, or polished and glazed. Characterization was performed using EDX, SEM, XRD with Rietveld refinement, Raman spectroscopy, and compressive testing before and after accelerated hydrothermal aging, according to EN ISO 13356:2015. EDX revealed a higher yttria content in monolithic zirconia (10.57 wt%) than in infrastructure zirconia (6.51 wt%). SEM images showed minimal changes in polished samples but clear surface damage after sandblasting, which was more pronounced with larger abrasive particles. XRD and Raman confirmed that sandblasting promoted the tetragonal (t-ZrO2) to monoclinic (m-ZrO2) phase transformation (t→m), amplified further by hydrothermal aging. The polished groups showed greater phase stability post-aging. Compressive strength decreased in all treated and aged samples, with monolithic zirconia being more affected. Polished samples displayed the best surface quality and structural resilience across both materials. These findings underline the impact of clinical surface treatments on zirconia's long-term mechanical and structural behavior.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies. 重新评估膜在种植体周围炎手术中的应用：体内研究的系统回顾和荟萃分析。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-15 DOI: 10.3390/jfb16070262

Young Joon Cho, Yong Tak Jeong, Hyun Nyun Woo, Hyun Woo Cho, Min Gu Kang, Sung-Min Hwang, Jae-Mok Lee

{"title":"Reassessing the Use of Membranes in Peri-Implantitis Surgery: A Systematic Review and Meta-Analysis of In Vivo Studies.","authors":"Young Joon Cho, Yong Tak Jeong, Hyun Nyun Woo, Hyun Woo Cho, Min Gu Kang, Sung-Min Hwang, Jae-Mok Lee","doi":"10.3390/jfb16070262","DOIUrl":"10.3390/jfb16070262","url":null,"abstract":"Peri-implantitis (PI) presents a growing challenge in implant dentistry, with regenerative surgical approaches often incorporating barrier membranes despite the uncertainty of their clinical value. This systematic review and meta-analysis of in vivo studies aimed to evaluate the efficacy of barrier membranes in the reconstructive surgical treatment of PI. A comprehensive electronic search was performed in PubMed, Scopus, Google Scholar, and the Cochrane Library, covering studies published from 1990 to 2024. The protocol followed PRISMA guidelines and was registered in PROSPERO (CRD42025625417). Eligible studies included in vivo investigations comparing regenerative procedures with and without membrane use, with a minimum follow-up of 6 months and at least 10 implants per study. Risk of bias (RoB) was assessed using the Cochrane RoB tool. The meta-analysis was conducted using a random-effects model and included 15 studies comprising 560 patients. Although not consistently statistically significant, the findings suggested that membrane use may offer enhanced outcomes in terms of probing pocket depth (PPD) reduction and marginal bone level (MLB) gain. The evidence was limited by high clinical heterogeneity, variability in outcome definitions, and short follow-up durations. While membranes are commonly utilized, current evidence does not justify their routine use. Further well-designed, long-term clinical trials are needed to establish specific indications and optimize treatment strategies.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Collagen Membrane Pretreated with Citrate Promotes Collagen Mineralization and Bone Regeneration. 柠檬酸预处理胶原膜促进胶原矿化和骨再生。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-15 DOI: 10.3390/jfb16070261

Qi Zhang, Yewen Zhong, Xinlin He, Sui Mai

{"title":"A Collagen Membrane Pretreated with Citrate Promotes Collagen Mineralization and Bone Regeneration.","authors":"Qi Zhang, Yewen Zhong, Xinlin He, Sui Mai","doi":"10.3390/jfb16070261","DOIUrl":"10.3390/jfb16070261","url":null,"abstract":"Purpose: Collagen membranes with biomimetic mineralization are emerging as promising materials for bone regeneration, owing to their high biocompatibility. In this study, we developed a biogenic collagen membrane by combining citrate (C) pretreatment and carboxymethyl chitosan (CMC)-mediated mineralization and further evaluated its bone healing potential. Methods: C-CMC collagen membranes were prepared by lyophilization. The mineral composition and content were tested through X-ray diffraction (XRD), Fourier transform infrared (FTIR), and thermogravimetric analysis (TGA). The micromorphology was observed using transmission electron microscopy (TEM), scanning electron microscopy (SEM), and scanning probe microscopy (SPM). Physical and mechanical properties, including the swelling rate, porosity, hydrophilicity, tensile strength, Young's modulus, degradation, and barrier function, were also evaluated. Bone mesenchymal stem cells (BMSCs) were cultured in vitro to observe their behavior. An in vivo critical-size rat calvarial defect model was used to validate the effects of the membrane on bone regeneration. Results: The C-CMC collagen membrane was successfully synthesized as a collagen-hydroxyapatite complex with intrafibrillar mineralization, exhibiting improved mechanical properties and an optimal swelling rate, porosity, hydrophilicity, and degradation rate. Additionally, the C-CMC collagen membrane promoted BMSC proliferation, adhesion, and osteogenesis while preventing epithelial cell infiltration. In vivo experiments indicated that C-CMC collagen membranes significantly stimulated bone regeneration without causing systemic toxicity. Conclusions: Our findings suggest that the C-CMC collagen membrane possesses satisfactory physical and mechanical properties, along with good biocompatibility and efficacy in bone defect regeneration, making it a potential candidate for a bioactive guided bone regeneration membrane in clinical applications.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Insertion Torque on Stress Distribution in Peri-Implant Bones Around Ultra-Short Implants: An FEA Study. 插入扭矩对超短种植体周围种植周骨应力分布的影响：有限元分析。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-14 DOI: 10.3390/jfb16070260

Mario Ceddia, Lorenzo Montesani, Luca Comuzzi, Alessandro Cipollina, Douglas A Deporter, Natalia Di Pietro, Bartolomeo Trentadue

{"title":"The Influence of Insertion Torque on Stress Distribution in Peri-Implant Bones Around Ultra-Short Implants: An FEA Study.","authors":"Mario Ceddia, Lorenzo Montesani, Luca Comuzzi, Alessandro Cipollina, Douglas A Deporter, Natalia Di Pietro, Bartolomeo Trentadue","doi":"10.3390/jfb16070260","DOIUrl":"10.3390/jfb16070260","url":null,"abstract":"Using ultra-short dental implants is a promising alternative to extensive bone grafting procedures for patients with atrophic posterior mandibles and vertical bone loss. However, the amount of insertion torque (IT) applied during implant placement significantly influences stress distribution in the peri-implant bone, which affects implant stability and long-term success.Materials and methods: This study used finite element analysis (FEA) to examine how different insertion torques (35 N·cm and 75 N·cm) affect stress distribution in cortical and trabecular bone types D2 and D4 surrounding ultra-short implants. Von Mises equivalent stress values were compared with ultimate bone strength thresholds to evaluate the potential for microdamage during insertion.Results: The findings demonstrate that increasing IT from 35 N·cm to 75 N·cm led to a significant increase in peri-implant bone stress. Specifically, cortical bone stress in D4 bone increased from approximately 79 MPa to 142 MPa with higher IT, exceeding physiological limits and elevating the risk of microfractures and bone necrosis. In contrast, lower IT values kept stress within safe limits, ensuring optimal primary stability without damaging the bone. These results underscore the need to strike a balance between achieving sufficient implant stability and avoiding mechanical trauma to the surrounding bone.Conclusions: Accurate control of insertion torque during the placement of ultra-short dental implants is crucial to minimize bone damage and promote optimal osseointegration. Excessive torque, especially in low-density bone, can compromise implant success by inducing excessive stress, thereby increasing the risk of early failure.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorogenic Acid-Strontium-Containing Dual-Functional Bioresorbable External Stent Suppresses Venous Graft Restenosis via Hippo-YAP Signaling Pathway. 绿原酸-含锶双功能生物可吸收支架通过Hippo-YAP信号通路抑制静脉移植物再狭窄。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-11 DOI: 10.3390/jfb16070259

Ge Zhu, Su Wang, Zhang Liu, Shengji Gu, Feng Chen, Wangfu Zang

{"title":"Chlorogenic Acid-Strontium-Containing Dual-Functional Bioresorbable External Stent Suppresses Venous Graft Restenosis via Hippo-YAP Signaling Pathway.","authors":"Ge Zhu, Su Wang, Zhang Liu, Shengji Gu, Feng Chen, Wangfu Zang","doi":"10.3390/jfb16070259","DOIUrl":"10.3390/jfb16070259","url":null,"abstract":"Vein graft restenosis remains a major complication following coronary artery bypass grafting (CABG), mainly due to the abnormal proliferation of vascular smooth muscle cells (VSMCs) and impaired endothelial repair. While external stents (eStents) can provide mechanical support and limit adverse remodeling, traditional metallic stents are non-degradable and may induce chronic inflammation and fibrosis. In contrast, many bioresorbable materials degrade too quickly or lack mechanical strength. These challenges highlight the need for external stents that combine sufficient mechanical strength with biodegradability to support long-term graft patency. This is the first study that develops a chlorogenic acid-strontium (SrCA)-loaded polycaprolactone bioresorbable eStent that inhibits VSMC proliferation and enhances endothelial repair via Hippo-Yes-associated protein (YAP) signaling, addressing vein graft restenosis post-CABG. Combining mechanical support and biodegradability, it overcomes the limitations of non-degradable stents and rapidly degrading biomaterials, elucidates the potential of natural polyphenol-metal ion complexes in vascular remodeling, and offers an innovative strategy for the prevention of vein graft restenosis.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Ag₂O/Ag Nanoparticles Using Puerarin: Characterization, Cytotoxicity, In Ovo Safety Profile, Antioxidant, and Antimicrobial Potential Against Nosocomial Pathogens. 利用葛根素合成Ag2O/Ag纳米颗粒：表征、细胞毒性、卵内安全性、抗氧化和抗医院病原体的抗菌潜力

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-11 DOI: 10.3390/jfb16070258

Sergio Liga, Raluca Vodă, Lavinia Lupa, Elena-Alina Moacă, Delia Muntean, Lucian Barbu-Tudoran, Maria Suciu, Vlad Socoliuc, Francisc Péter

{"title":"Synthesis of Ag2O/Ag Nanoparticles Using Puerarin: Characterization, Cytotoxicity, In Ovo Safety Profile, Antioxidant, and Antimicrobial Potential Against Nosocomial Pathogens.","authors":"Sergio Liga, Raluca Vodă, Lavinia Lupa, Elena-Alina Moacă, Delia Muntean, Lucian Barbu-Tudoran, Maria Suciu, Vlad Socoliuc, Francisc Péter","doi":"10.3390/jfb16070258","DOIUrl":"10.3390/jfb16070258","url":null,"abstract":"(1) Background: Our study investigates the green synthesis of Ag2O/Ag nanoparticles using the isoflavone Puerarin as a bioreductor. (2) Methods: The PUE@Ag2O/Ag nanoparticles were characterized using various techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), electronic microscopy (TEM, SEM), energy dispersive X-ray spectroscopy (EDX), and dynamic light scattering (DLS). Biological activities were assessed through antimicrobial testing, cytotoxicity assays on human keratinocytes and melanoma cells, and an in ovo screening using the HET-CAM assay. (3) Results: The formation of crystalline Ag2O/Ag nanoparticles with sizes below 100 nm was accomplished with Puerarin. Despite their high cytotoxicity at all tested concentrations, the nanoparticles showed antioxidant activity with IC50 981.5 ± 94.2 μg/mL, antibacterial activity against several clinically relevant nosocomial strains (Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa), and no local irritant effects or inhibition of angiogenesis in the HET-CAM assay. (4) Conclusions: This study provides insights into the synthesis, characterization, and biological profile of PUE@Ag2O/Ag nanoparticles for potential biomedical applications.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Additive and Subtractive Manufacturing on the Adhesion and Durability of Titanium-Zirconia Restorative Materials. 增材制造和减材制造对钛-氧化锆修复材料附合力和耐久性的影响。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-11 DOI: 10.3390/jfb16070257

Omar Alageel, Najm Alfrisany, Abdullah Alshamrani, Omar Alsadon

{"title":"The Impact of Additive and Subtractive Manufacturing on the Adhesion and Durability of Titanium-Zirconia Restorative Materials.","authors":"Omar Alageel, Najm Alfrisany, Abdullah Alshamrani, Omar Alsadon","doi":"10.3390/jfb16070257","DOIUrl":"10.3390/jfb16070257","url":null,"abstract":"This study aimed to investigate the bonding strength and durability of titanium alloys bonded to zirconia-based materials produced using subtractive and additive digital methods. Two titanium alloy groups (N = 20) and two zirconia ceramic groups (N = 60) were fabricated using CAD/CAM milling from prefabricated discs (Ti-ML and Zr-ML), and 3D printing via SLM (Ti-3D) and DLP/LCM systems (Zr-3D). The specimens were bonded with dental cement to form four test groups: Zr-ML/Ti-ML, Zr-ML/Ti-3D, Zr-3D/Ti-ML, and Zr-3D/Ti-3D. Half of the specimens in each group underwent thermocycling to assess the effect of aging on bond strength. The density, microhardness, and surface morphology were evaluated, along with the shear bond strength and failure modes of the resin composites. Statistical differences were analyzed using one-way ANOVA and Tukey's HSD test across all groups. The 3D-printed specimens of both materials exhibited higher microhardness and lower surface roughness than the milled specimens. The shear bond strength (SBS) was the highest in the Ti-ML/Zr-ML combination group before and after thermocycling, which had more cohesive failures, whereas the lowest bond strength was observed in the Ti-3D/Zr-ML group. The adhesion between titanium and zirconia-based materials was the strongest when both were fabricated using subtractive methods, followed by additive and mixed-method combinations.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent Catheters with Integrated Amphiphilic Surfactant Reduce Urethral Microtrauma in an Ex Vivo Model Compared with Polyvinylpyrrolidone-Coated Intermittent Catheters. 与聚乙烯吡咯烷酮包被间歇导尿管相比，集成两亲性表面活性剂间歇导尿管在离体模型中减少尿道微创伤。

IF 5.2 3区医学

Journal of Functional Biomaterials Pub Date : 2025-07-10 DOI: 10.3390/jfb16070256

Luca Barbieri, Makhara S Ung, Katherine E Hill, Ased Ali, Laura A Smith Callahan

{"title":"Intermittent Catheters with Integrated Amphiphilic Surfactant Reduce Urethral Microtrauma in an Ex Vivo Model Compared with Polyvinylpyrrolidone-Coated Intermittent Catheters.","authors":"Luca Barbieri, Makhara S Ung, Katherine E Hill, Ased Ali, Laura A Smith Callahan","doi":"10.3390/jfb16070256","DOIUrl":"10.3390/jfb16070256","url":null,"abstract":"Intermittent catheterization mitigates urinary retention for over 300,000 people in the US every year, but can cause microtrauma in the urothelium, compromising its barrier function and increasing the risk of pathogen entry, which may affect user health. To reduce adverse effects, intermittent catheters (ICs) with increased lubricity are used. A common strategy to enhance IC lubricity is to apply a polyvinylpyrrolidone (PVP) coating to ICs; however, this coating can become adhesive upon drying, potentially leading to microtrauma. An alternative approach for lubricity is the migration of integrated amphiphilic surfactant (IAS) within the IC to the surface. The present work examines differences in urethral microtrauma caused by the simulated catheterization of ex vivo porcine urethral tissue using PVP-coated and IAS ICs. Scanning electron microscopy and fluorescence microscopy of the tissue showed the removal of the apical cell layer after contact with the PVP-coated ICs, but not the IAS IC. More extracellular matrices and DNA were observed on the PVP-coated ICs than the IAS IC after tissue contact. Contact angle analysis of the polar and dispersive components of the surface energy demonstrated that the PVP-coated ICs promoted mucoadhesion, while the IAS IC limited mucoadhesion. Overall, the results indicate that IAS ICs cause less microtrauma to urethral tissue than traditional PVP-coated ICs.","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"16 7","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0