Journal of Functional Biomaterials最新文献

{"title":"Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System.","authors":"Hui Li, Junwei Liu, Jingru Wang, Zhuoyue Li, Jianming Yu, Xu Huang, Bingchuan Wan, Xiangbao Meng, Xuan Zhang","doi":"10.3390/jfb15120372","DOIUrl":"10.3390/jfb15120372","url":null,"abstract":"<p><p><b>Background:</b> CY1-4, 9-nitropyridine [2',3':4,5] pyrimido [1,2-α] indole -5,11- dione, is an indoleamine 2,3-dioxygenase (IDO) inhibitor and a poorly water-soluble substance. It is very important to increase the solubility of CY1-4 to improve its bioavailability and therapeutic effect. In this study, the mesoporous silica nano-skeleton carrier material Sylysia was selected as the carrier to load CY1-4, and then the CY1-4 nano-skeleton drug delivery system (MSNM@CY1-4) was prepared by coating the hydrophilic polymer material Hydroxypropyl methylcellulose (HPMC) and the lipid material Distearoylphosphatidyl-ethanolamine-poly(ethylene glycol)₂₀₀₀ (DSPE-PEG₂₀₀₀) to improve the anti-tumor effect of CY1-4. <b>Methods</b>: The solubility and dissolution of MSNM@CY1-4 were investigated, and its bioavailability, anti-tumor efficacy, IDO inhibitory ability and immune mechanism were evaluated in vivo. <b>Results</b>: CY1-4 was loaded in MSNM@CY1-4 in an amorphous form, and MSNM@CY1-4 could significantly improve the solubility (up to about 200 times) and dissolution rate of CY1-4. In vivo studies showed that the oral bioavailability of CY1-4 in 20 mg/kg MSNM@CY1-4 was about 23.9-fold more than that in 50 mg/kg CY1-4 suspension. In B16F10 tumor-bearing mice, MSNM@CY1-4 significantly inhibited tumor growth, prolonged survival time, significantly inhibited IDO activity in blood and tumor tissues, and reduced Tregs in tumor tissues and tumor-draining lymph nodes to improve anti-tumor efficacy. <b>Conclusions</b>: The nano-skeleton drug delivery system (MSNM@CY1-4) constructed in this study is a potential drug delivery platform for improving the anti-tumor effect of oral poorly water-soluble CY1-4.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microstructural and Surface Texture Evaluation of Orthodontic Microimplants Covered with Bioactive Layers Enriched with Silver Nanoparticles.","authors":"Magdalena Sycińska-Dziarnowska, Magdalena Ziąbka, Katarzyna Cholewa-Kowalska, Gianrico Spagnuolo, Hyo-Sang Park, Steven J Lindauer, Krzysztof Woźniak","doi":"10.3390/jfb15120371","DOIUrl":"10.3390/jfb15120371","url":null,"abstract":"<p><p>Bacterial infections are a common cause of clinical complications associated with the use of orthodontic microimplants. Biofilm formation on their surfaces and subsequent infection of peri-implant tissues can result in either exfoliation or surgical removal of these medical devices. In order to improve the properties of microimplants, hybrid coatings enriched with silver nanoparticles, calcium, and phosphorus were investigated. The present study aimed to assess the microstructure of commercially available microimplants composed of a medical TiAlV (Ti6Al4V) alloy covered with organic-inorganic layers obtained by the sol-gel method using the dip-coating technique. The microstructures and elemental surface compositions of the sterile, etched, and layer-modified microimplants were characterized by scanning electron microscopy with X-ray energy-dispersive spectroscopy (SEM-EDS). Elements such as silver (Ag), calcium (Ca), phosphorus (P), silicon (Si), oxygen (O), and carbon (C) were detected on the microimplant's surface layer. The SEM observations revealed that control microimplants (unetched) had smooth surfaces with only manufacturing-related embossing, while etching in hydrofluoric acid increased the surface roughness and introduced fluoride onto the microimplants. Layers with only silver nanoparticles reduced the roughness of the implant surface, and no extrusion was observed, while increased roughness and emerging porosity were observed when the layers were enriched with calcium and phosphorus. The highest roughness was observed in the microimplants etched with AgNPs and CaP, while the AgNPs-only layer showed a reduction in the roughness average parameter due to lower porosity. Enhancing the effectiveness of microimplants can be achieved by applying selective surface treatments to different parts. By keeping the outer tissue contact area smooth while making the bone contact area rough to promote stronger integration with bone tissue, the overall performance of the implants can be significantly improved.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of Chitosan-Based Irrigation Solutions on the Bond Strength of Mineral Trioxide Aggregate to Bulk-Fill Composite.","authors":"Arzu Şahin Mantı, Bağdagül Helvacıoğlu Kıvanç","doi":"10.3390/jfb15120370","DOIUrl":"10.3390/jfb15120370","url":null,"abstract":"<p><p><b>(1) Background:</b> Bond strength between repair and restorative materials is crucial for endodontic success. This study assessed the effects of the following final irrigation solutions on the bond strength of mineral trioxide aggregate (MTA) to a bulk-fill composite: (1) 17% Ethylenediamine tetraacetic acid (EDTA); (2) 2% Chlorhexidine (CHX); (3) 0.2% chitosan; (4) 0.2% chitosan with 2% CHX; 5) 0.2% chitosan with AgNPs. <b>(2) Methods</b>: Sixty MTA samples were divided into six groups (<i>n</i> = 10) based on the final irrigation solution: 1. EDTA, 2. CHX, 3. Chitosan, 4. Chitosan-CHX, 5. Chitosan-AgNP, and 6. distilled water (control). After a 5-min solution exposure, each sample was restored with the bulk-fill composite, and the shear bond strength (SBS) was measured. Structural changes in MTA were analyzed using SEM and EDS, and failure modes were classified as adhesive, cohesive, or mixed. Data were analyzed by one-way ANOVA with Tamhane's T2 and Tukey's tests (α = 0.05). <b>(3) Results:</b> EDTA exhibited the lowest SBS (<i>p</i> < 0.001), while Chitosan-CHX showed the highest. SEM showed a spongy, void-rich surface in EDTA-treated MTA, with significant Ca depletion per EDS. Chitosan-CHX showed no structural change. Cohesive fractures within MTA were predominant. <b>(4) Conclusions</b>: EDTA significantly reduces SBS, while chitosan with CHX enhances bond strength.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Mathematical Model and In Vivo Study of Calcium Phosphate Bone Grafts.","authors":"Mikhail A Shlykov, Polina V Smirnova, Anatoliy S Senotov, Anastasia Yu Teterina, Vladislav V Minaychev, Igor V Smirnov, Roman A Novikov, Ekaterina I Marchenko, Pavel S Salynkin, Vladimir S Komlev, Roman S Fadeev, Irina S Fadeeva","doi":"10.3390/jfb15120368","DOIUrl":"10.3390/jfb15120368","url":null,"abstract":"<p><p>One of the key factors of the interaction 'osteoplastic material-organism' is the state of the implant surface. Taking into account the fact that the equilibrium in regeneration conditions is reached only after the reparative histogenesis process is completed, the implant surface is constantly modified. This work is devoted to the numerical description of the dynamic bilateral material-medium interaction under close to physiological conditions, as well as to the assessment of the comparability of the model with <i>in vitro</i> and <i>in vivo</i> experimental results. The semi-empirical model obtained on the basis of chemical kinetics allows us to describe numerically the processes occurring in the <i>in vitro</i> systems and extrapolates well to assess the behavior of dicalcium phosphate dihydrate (DCPD) material under conditions of ectopic (subcutaneous) implantation in Wistar rats. It is shown that an experiment conducted using a perfusion-diffusion bioreactor in a cell culture medium with the addition of fetal bovine serum (FBS) allows for achieving morphologically and chemically identical changes in the surface of the material in comparison with the real organism. This fact opens up wide possibilities for the creation of an analog of a 'laboratory-on-a-chip' and the transition from classical <i>in vivo</i> models to more controlled and mathematically based <i>in vitro</i> systems.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide Hydrogel for Sustained Release of Recombinant Human Bone Morphogenetic Protein-2 In Vitro.","authors":"Dalin Wang, Guangyan Qi, Mingcai Zhang, Brandon Carlson, Matthew Gernon, Douglas Burton, Xiuzhi Susan Sun, Jinxi Wang","doi":"10.3390/jfb15120369","DOIUrl":"10.3390/jfb15120369","url":null,"abstract":"<p><p>This study aimed to investigate the impact of varying the formulation of a specific peptide hydrogel (PepGel) on the release kinetics of rhBMP-2 in vitro. Three PepGel formulations were assessed: (1) 50% <i>v</i>/<i>v</i> (peptides volume/total volume) PepGel, where synthetic peptides were mixed with crosslinking reagents and rhBMP-2 solution; (2) 67% <i>v</i>/<i>v</i> PepGel; (3) 80% <i>v</i>/<i>v</i> PepGel. Each sample was loaded with 12 µg of rhBMP-2 and incubated in PBS. Released rhBMP-2 was quantified by ELISA at 1 h, 6 h, and 1, 2, 4, 7, 10, 14, and 21 days. To explore how PepGel formulations influence rhBMP-2 release, the gel porosities, swelling ratios, and mechanical properties of the three PepGel formulations were quantitatively analyzed. The results showed that rhBMP-2 encapsulated with 50% <i>v</i>/<i>v</i> PepGel exhibited a sustained release over the 21-day experiment, while the 67% and 80% <i>v</i>/<i>v</i> PepGels demonstrated significantly lower rhBMP-2 release rates compared to the 50% formulation after day 7. Higher histological porosity of PepGel was significantly correlated with increased rhBMP-2 release rates. Conversely, the swelling ratio and elastic modulus of the 50% <i>v</i>/<i>v</i> PepGel were significantly lower than that of the 67% and 80% <i>v</i>/<i>v</i> formulations. In conclusion, this study indicates that varying the formulation of crosslinked PepGel can control rhBMP-2 release rates in vitro by modulating gel porosity, swelling ratio, and mechanical properties. Encapsulation with 50% <i>v</i>/<i>v</i> PepGel offers a sustained rhBMP-2 release pattern in vitro; if replicated in vivo, this could mitigate the adverse effects associated with burst release of rhBMP-2 in clinical applications.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning and Metabolomics Predict Mesenchymal Stem Cell Osteogenic Differentiation in 2D and 3D Cultures.","authors":"Michail E Klontzas, Spyros I Vernardis, Aristea Batsali, Fotios Papadogiannis, Nicki Panoskaltsis, Athanasios Mantalaris","doi":"10.3390/jfb15120367","DOIUrl":"10.3390/jfb15120367","url":null,"abstract":"<p><p>Stem cells have been widely used to produce artificial bone grafts. Nonetheless, the variability in the degree of stem cell differentiation is an inherent drawback of artificial graft development and requires robust evaluation tools that can certify the quality of stem cell-based products and avoid source-tissue-related and patient-specific variability in outcomes. Omics analyses have been utilised for the evaluation of stem cell attributes in all stages of stem cell biomanufacturing. Herein, metabolomics in combination with machine learning was utilised for the benchmarking of osteogenic differentiation quality in 2D and 3D cultures. Metabolomics analysis was performed with the use of gas chromatography-mass spectrometry (GC-MS). A set of 11 metabolites was used to train an XGboost model which achieved excellent performance in distinguishing between differentiated and undifferentiated umbilical cord blood mesenchymal stem cells (UCB MSCs). The model was benchmarked against samples not present in the training set, being able to efficiently capture osteogenesis in 3D UCB MSC cultures with an area under the curve (AUC) of 82.6%. On the contrary, the model did not capture any differentiation in Wharton's Jelly MSC samples, which are well-known underperformers in osteogenic differentiation (AUC of 56.2%). Mineralisation was significantly correlated with the levels of fumarate, glycerol, and myo-inositol, the four metabolites found most important for model performance (R² = 0.89, R² = 0.94, and R² = 0.96, and <i>p</i> = 0.016, <i>p</i> = 0.0059, and <i>p</i> = 0.0022, respectively). In conclusion, our results indicate that metabolomics in combination with machine learning can be used for the development of reliable potency assays for the evaluation of Advanced Therapy Medicinal Products.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11680063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Degradation Properties of Plasma Electrolytically Oxidized Mg Alloy AZ31 Using Fluid Dynamic Accelerated Tests for Biodegradable Implants.","authors":"Muhammad Saqib, Kerstin Kremmer, Joerg Opitz, Michael Schneider, Natalia Beshchasna","doi":"10.3390/jfb15120366","DOIUrl":"10.3390/jfb15120366","url":null,"abstract":"<p><p>Magnesium alloys are promising biodegradable implant materials due to their excellent biocompatibility and non-toxicity. However, their poor corrosion resistance limits their application in vivo. Plasma electrolytic oxidation (PEO) is a powerful technique to improve the corrosion resistance of magnesium alloys. In this study, we present the accelerated degradation of PEO-treated AZ31 samples using a fluid dynamic test. The samples were prepared using different concentrations of KOH as an electrolyte along with NaSiO₃. The anodizing time and the biasing time were optimized to obtain the increased corrosion resistance. The analysis of the degraded samples using microscopy, SEM EDX measurements, and by calculating mass loss and corrosion rates showed a significant increase in the corrosion resistance after the polymer (Resomer© LG 855 S) coating was applied to the anodized samples. The results confirm (or convince) that PEO treatment is an effective way to improve the corrosion resistance of AZ31 magnesium alloy. The fluid dynamic test can be used as an accelerated degradation test for biodegradable alloys in simulated body fluids at a physiological temperature. The polymer coating further improves the corrosion resistance of the PEO-treated AZ31 samples.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.","authors":"Nino Maisuradze, Shalva Kekutia, Jano Markhulia, Tamar Tsertsvadze, Vladimer Mikelashvili, Liana Saneblidze, Nikoloz Chkhaidze, Zsolt Endre Horváth, László Almásy, Nunu Mitskevichi","doi":"10.3390/jfb15120364","DOIUrl":"10.3390/jfb15120364","url":null,"abstract":"<p><p>The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution. Various techniques, including dynamic light scattering (DLS), electrophoretic light scattering (ELS), X-ray diffraction (XRD), and transmission electron microscopy (TEM), were employed to examine the particle size, zeta potential, structure, and morphology. Magnetic properties were analyzed through vibrating sample magnetometry (VSM), and surface modifications were confirmed via UV-visible (UV-Vis) and Fourier-Transform Infrared (FTIR) spectroscopy. Cytotoxicity and drug delivery efficiency were evaluated in vitro using RM1 (prostate cancer) and MEC1 (chronic lymphocytic leukemia) cell lines. Fluorescence microscopy demonstrated the successful intracellular delivery of doxorubicin, showcasing the nanoparticles' potential for targeted cancer therapy. However, folic-acid-conjugated nanoparticles exhibited diminished effectiveness over time. This study highlights the importance of nanoparticle optimization for enhancing therapeutic performance. Further research should aim to improve nanoparticle formulations and explore their long-term impacts for the development of safe, targeted cancer treatments.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feature Papers in Bone Biomaterials.","authors":"Zifei Zhou, Feng Chen","doi":"10.3390/jfb15120365","DOIUrl":"10.3390/jfb15120365","url":null,"abstract":"<p><p>Bone biomaterials have garnered significant attention in the field of regenerative medicine due to their application in a wide range of clinical scenarios [...].</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans.","authors":"Yasuo Komura, Shintarou Kimura, Yumi Hirasawa, Tomoko Katagiri, Ayana Takaura, Fumika Yoshida, Saki Fukuro, Hiromi Muranishi, Osamu Imataki, Koichiro Homma","doi":"10.3390/jfb15120363","DOIUrl":"10.3390/jfb15120363","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is a minimally invasive treatment that elicits tumor apoptosis using laser light exclusively applied to the tumor site. IR-783, a heptamethine cyanine (HMC) dye, impedes the proliferation of breast cancer cells, even without light. Although studies have investigated the efficacy of IR-783 in cell and animal studies, its efficacy in clinical settings remains unknown. Therefore, we aimed to determine the efficacy of PDT using IR-783 liposomes. An HMC dye, excited by long-wavelength infrared light and with high tissue permeability, was used for PDT after liposomization to enhance tumor tissue accumulation. PDT was performed using IR-783 in two patients with either tongue or breast cancer, one each. IR-783 liposomes inhibited cell proliferation in tongue cancer cells even when not excited by light. Tumor size was markedly reduced in both cases, with no significant adverse events. Furthermore, the patient with tongue cancer exhibited improved respiratory, swallowing, and speech functions, which were attributed not only to the shrinkage of the tumor but also to the improvement in airway narrowing. In conclusion, PDT using IR-783 liposomes effectively reduces tumor size in tongue and breast cancers.</p>","PeriodicalId":15767,"journal":{"name":"Journal of Functional Biomaterials","volume":"15 12","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}