Journal of dentistry最新文献

{"title":"Anti-erosive effect of fluoride solutions associated with methacrylate polymer: A randomized crossover in situ study","authors":"Taiana Paola Prado ,&nbsp;Karine Carvalho Santos ,&nbsp;Carlos Rocha Gomes Torres ,&nbsp;Taís Scaramucci ,&nbsp;Idalina Vieira Aoki ,&nbsp;Alessandra Buhler Borges","doi":"10.1016/j.jdent.2025.105944","DOIUrl":"10.1016/j.jdent.2025.105944","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the anti-erosive effect of solutions containing fluoride and aminomethacrylate copolymer associations on enamel and dentin, using a randomized crossover in situ model.</div></div><div><h3>Methods</h3><div>Bovine enamel and dentin specimens were fixed in intraoral devices. Participants (<em>n</em> = 12) installed the devices and rinsed with seven experimental solutions in a randomized sequence, with 2-day washout between them: Ultrapure water-C; Sodium fluoride-F (225 ppmF-); Stannous Chloride-Sn (800 ppm Sn2+); Aminomethacrylate- AA (2 %); FSn; <em>F</em>+AA; FSn+AA. After treatments, they retained the device for acquired pellicle maturation (30 min). Specimens were then extraorally exposed to 0.03 % HCl, pH 2.3 (3 min). This cycling was repeated six times. Calcium released from the acid solutions was measured photometrically, and mineral loss (ML) was calculated. KOHsoluble fluoride (μg/cm2) and surface microhardness (KHNred) were also measured. Data were submitted to RM-ANOVA and Tukey tests (5 %).</div></div><div><h3>Results</h3><div>For mineral loss in enamel, the <em>F</em>+AA and FSn+AA solutions were statistically superior than F and FSn, respectively. In dentin, the <em>F</em>+AA solution showed the best performance (<em>p</em> &lt; 0.001). The KHNred results for the enamel were: <em>C</em> = Sn &lt; AA = <em>F</em> = FSn &lt; <em>F</em>+AA = FSn+AA. The FSn groups exhibited higher concentration of fluoride adsorbed on both enamel and dentin surface (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The addition of aminomethacrylate copolymer to fluoride solutions improved their efficacy in protecting the tooth against erosion in the presence of acquired pellicle, being a promising agent to be incorporated in mouthrinses.</div></div><div><h3>Clinical significance</h3><div>The investigation of the anti-erosive effect of polymers and fluoride provides subsidies for identifying the most promising associations, which open new perspectives for the development of formulations capable of preventing erosion progression to more advanced stages, which requires complex and costly restorative interventions.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105944"},"PeriodicalIF":4.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General health-related quality of life and oral health in older adults: A systematic review","authors":"Huihua Li ,&nbsp;Christina P.C. Sim ,&nbsp;Daniela de Rossi Figueiredo ,&nbsp;Karen G. Peres","doi":"10.1016/j.jdent.2025.105942","DOIUrl":"10.1016/j.jdent.2025.105942","url":null,"abstract":"<div><h3>Objectives</h3><div>To systematically review the association between oral health conditions and older adults' general health-related quality-of-life (HRQoL).</div></div><div><h3>Data</h3><div>Population-based observational studies and randomised clinical trials addressing associations between oral health conditions and HRQoL in adults aged 60 or older were considered for inclusion following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Newcastle-Ottawa scale was used to assess the quality of the selected studies.</div></div><div><h3>Sources</h3><div>The PubMed/Medline, EMBASE, Web of Science, and SciELO databases were systematically searched using the validated strategy, following the guidelines of the Peer Review of Electronic Search Strategies (PRESS) guidelines, up to February 7, 2025.</div></div><div><h3>Study selection</h3><div>This review included 35 cross-sectional and 3 cohort studies from 36 articles, encompassing 111,592 participants from 18 countries, with sample sizes ranging from 103 to 27,629. Twelve HRQoL instruments were identified, with the most commonly used being EuroQoL (<em>n</em> = 12), SF-36 and its short versions (<em>n</em> = 9), and WHOQOL (<em>n</em> = 6). The number of teeth was the most studied oral health exposure (<em>n</em> = 27), followed by chewing difficulty (<em>n</em> = 12). Thirteen articles reported adjusted analyses. Overall, having fewer teeth (<em>n</em> = 21) and experiencing chewing difficulty (<em>n</em> = 11) were associated with worse HRQoL.</div></div><div><h3>Conclusions</h3><div>Fewer teeth and chewing difficulty negatively impacted HRQoL, with chewing difficulty emerging as a novel finding in systematic reviews.</div></div><div><h3>Clinical significance</h3><div>Healthcare providers should implement targeted interventions to maintain functional teeth and improve chewing ability in older adults. This approach will enhance their overall physical, mental, and social well-being, ultimately improving their quality of life and longevity.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105942"},"PeriodicalIF":4.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiovascular diseases and apical periodontitis: An umbrella review with stratification of evidence and sensitivity analysis","authors":"Adinath Walmik Talekar ,&nbsp;Dax Abraham ,&nbsp;Aakansha Puri ,&nbsp;Alpa Gupta ,&nbsp;Karina Singal ,&nbsp;Neha Neha","doi":"10.1016/j.jdent.2025.105943","DOIUrl":"10.1016/j.jdent.2025.105943","url":null,"abstract":"<div><h3>Objectives</h3><div>To systematically evaluate epidemiological evidence regarding cardiovascular disease (CVD) and apical periodontitis (AP) associations through umbrella review methodology.</div></div><div><h3>Data</h3><div>Ten systematic reviews were synthesized, including five meta-analyses encompassing 1108–673,083 participants. Meta-analytical effect sizes demonstrated relative risks ranging from 1.20 to 1.38, odds ratios of 1.53 to 2.94, with substantial between-study heterogeneity (I² = 54 %-100 %). The pooled estimates of RR studies were 1.32[1.0 to 1.62; <em>p</em> = 0.007] and for Odds ratio 1.83[1.33 to 2.53; <em>P</em> &lt; 0.001]. Evidence stratification revealed significant heterogeneity in effect magnitudes, methodological approaches, and study quality assessments.</div></div><div><h3>Sources</h3><div>Comprehensive searches of PubMed/MEDLINE, Scopus, EBSCO Host, and multiple grey-literature repositories were conducted from database inception to February 2025, using optimized strategies that integrated Medical Subject Headings, Boolean logic, truncation, and proximity operators.</div></div><div><h3>Study selection</h3><div>Dual independent reviewer screening identified systematic reviews examining CVD-AP associations. Following duplicate removal and consensus resolution, 10 systematic reviews were included from 7472 initially screened articles.</div></div><div><h3>Conclusion</h3><div>This umbrella review of ten systematic reviews—including five meta-analyses spanning 1108 to 673,083 participants—demonstrates a consistent, moderately elevated cardiovascular risk associated with apical periodontitis. Pooled estimates showed a 32 % increase in relative risk (RR = 1.32, 95 % CI = 1.00–1.62; <em>p</em> = 0.007) and an 83 % higher odds of cardiovascular disease (OR = 1.83, 95 % CI = 1.33–2.53; <em>p</em> &lt; 0.001). However, substantial between-study heterogeneity (I² = 54 – 100 %) and variability in diagnostic criteria temper causal inference.</div></div><div><h3>Clinical Significance</h3><div>Collectively, the evidence supports AP as an independent, clinically important marker of cardiovascular vulnerability, justifying intensified prevention and management of endodontic infection within cardiometabolic risk reduction strategies. Future large, prospective cohorts employing standardized AP definitions and rigorous confounder control are needed to clarify dose-response patterns and underlying mechanisms.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105943"},"PeriodicalIF":4.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of novel solvent formula of primer containing functional monomer on improving the durability of dentin adhesion","authors":"Shanshan Feng,&nbsp;Shihui Yang,&nbsp;Shuwei Qiao,&nbsp;Zilu Tian,&nbsp;Qi Lin,&nbsp;Lingkang Lin,&nbsp;Xi He,&nbsp;Song Zhu","doi":"10.1016/j.jdent.2025.105945","DOIUrl":"10.1016/j.jdent.2025.105945","url":null,"abstract":"<div><h3>Objective</h3><div>The study was designed to investigate how varying ratios of a functional monomer, 4-formylphenyl acrylate (FA) primer, formulated with a blend of ethyl-acetate (EAC) and ethanol (ET), impact the adhesive durability of All Bond Universal (ABU) and Single Bond Universal (SBU) under both etching and rinsing modes.</div></div><div><h3>Methods</h3><div>FA was synthesized via the acyl chloride reaction. FA primer was prepared by mixing ethyl acetate and ethanol as a binary solvent system at solvent ratios of 7:3, 6:4, 5:5, and 4:6. The optimal ratio of ethyl acetate to ethanol was determined by measuring the degree of conversion (DC) and contact angle, combining the microtensile bond strength (µTBS) and fracture pattern immediately and 10,000 thermocycles. Matrix metalloproteinases (MMPs) activities and adhesive infiltration at the interface were observed, whereas scanning electron microscopy was used to further evaluate nanoleakage and resin rags.</div></div><div><h3>Results</h3><div>Application of the primer containing a mixed EAC:ET-4:6 solvent resulted in a significant enhancement in the µTBS of both immediate and aging groups, and the contact angle of the demineralized dentin surface. Confocal Laser Scanning Microscope (CLSM) and Scanning Electron Microscope (SEM) were further observed the infiltration properties of resin rags in the bonding interface were strengthened. The MMPs activities in the hybrid layer was clearly inhibited, and the degree of nanoleakage at the bonding interface reduced remarkably, thus, it improved the stability and durability of the bond.</div></div><div><h3>Conclusion</h3><div>FA primers containing appropriate ratios of ethanol and ethyl acetate solvents can simplify operation procedures, enhances collagen fiber resistance to enzymatic degradation, and improves hybrid layer sealing, thereby increasing bonding strength.</div></div><div><h3>Clinical Significance</h3><div>The FA primer formulated with an ethyl acetate-ethanol mixed solvent aim to achieve high-strength, low leakage, and long-term durable adhesive effects, demonstrating dual functional advantages: Effective collagen crosslinking capacity leading to enhanced bond durability and reduced secondary caries incidence, alongside decreased technique sensitivity. These findings provide novel perspectives for FA primer applications in clinical practice.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105945"},"PeriodicalIF":4.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pellicle engineering with CaneCPI-5: a scoping review","authors":"João Victor Frazão Câmara ,&nbsp;Anton Schestakow ,&nbsp;Carolina Ruis Ferrari ,&nbsp;Matthias Hannig ,&nbsp;Marília Afonso Rabelo Buzalaf","doi":"10.1016/j.jdent.2025.105939","DOIUrl":"10.1016/j.jdent.2025.105939","url":null,"abstract":"<div><h3>Objectives</h3><div>The salivary pellicle regulates interfacial processes on dental surfaces, offering protection against erosion and influencing bacterial adhesion. CaneCPI-5, a sugarcane-derived peptide inspired by cystatins, has been proposed as a cost-effective agent for pellicle modification. This scoping review evaluates the potential of CaneCPI-5 in pellicle engineering, particularly regarding erosion prevention and bacterial adhesion.</div></div><div><h3>Data</h3><div>Studies investigating the effects of CaneCPI-5 on pellicles formed by human saliva on enamel or dentin were included.</div></div><div><h3>Sources</h3><div>A literature search was conducted in Medline, Scopus, and Web of Science up to May 2025. Only English-language research articles were considered. Hand-searching, including checking reference lists, was not conducted.</div></div><div><h3>Study selection</h3><div>A total of 131 records were identified. After removing duplicates, the titles, abstracts and full-text were screened, resulting in 20 included studies. Most studies were conducted on enamel pellicles (<em>n</em> = 17), with some on dentin (<em>n</em> = 2) or both (<em>n</em> = 1). CaneCPI-5 demonstrated enamel-binding ability and modified the pellicle proteome by increasing acid-resistant proteins, enhancing resistance to erosion. Its effects on bacterial adhesion and caries prevention were inconsistent. Combinations with other agents, particularly vitamin E, showed synergistic effects, though overall findings were mixed.</div></div><div><h3>Conclusions</h3><div>CaneCPI-5 shows promise as a pellicle-modifying agent for erosion protection. However, current evidence is limited, and findings remain inconclusive, merit further research under clinically relevant conditions.</div></div><div><h3>Clinical significance</h3><div>Intentional modification of the pellicle with peptides like CaneCPI-5 may improve its protective properties and support preventive measures. Nonetheless, the long-term effects and clinical applicability of such modifications remain unclear. Further studies are needed to confirm their efficacy in the dynamic oral environment.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105939"},"PeriodicalIF":4.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in oral microbiome in preschool children after using toothpaste with different fluoride concentrations","authors":"Wenhao Zhang ,&nbsp;Qiu Yan Xie ,&nbsp;Sui Huang ,&nbsp;Chun Hung Chu ,&nbsp;Edward Chin Man Lo","doi":"10.1016/j.jdent.2025.105941","DOIUrl":"10.1016/j.jdent.2025.105941","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental caries is a multifactorial disease primarily driven by an imbalanced oral microbiome, with cariogenic bacteria in dental plaque playing a central role. Fluoride-containing toothpaste is commonly used for caries prevention, but its effects on the oral microbiome, particularly at different fluoride concentrations, remain unclear. This study aimed to assess the short-term impact of fluoride toothpaste with different fluoride concentrations (standard fluoride 1000 ppm, low fluoride 500 ppm, and non-fluoride) on the oral microbial community in preschool children.</div></div><div><h3>Methods</h3><div>A total of 48 children participated, with dental plaque samples collected at baseline, and at 1-week and 4-week follow-up after using the assigned toothpaste. The microbial community was analyzed using 16S rDNA sequencing to evaluate diversity, composition and shifts in bacterial populations.</div></div><div><h3>Results</h3><div>The results showed no significant differences in alpha diversity indices (Chao1, Shannon, Simpson, etc.) between pre- and post-intervention samples in all groups, indicating overall microbial stability. However, beta diversity analysis revealed significant differences in microbial composition between the fluoride and non-fluoride groups. Notably, the standard fluoride group exhibited a more substantial shift in bacterial structure, with an increase in the abundance of beneficial species such as <em>Streptococcus parasanguinis and Veillonella</em>, and a reduction in genus, such as <em>Haemophilus</em> and <em>Neisseria</em>, which are associated with biofilm formation and may affect the colonization of cariogenic bacteria.</div></div><div><h3>Conclusion</h3><div>These findings suggest that fluoride-containing toothpaste, especially standard fluoride (1000 ppm) toothpaste, can modulate the oral microbiome by decreasing harmful bacteria and promoting a more balanced microbial environment, potentially reducing the risk of dental caries in preschool children.</div></div><div><h3>Clinical Significance</h3><div>This study demonstrates that standard fluoride (1000 ppm) toothpaste effectively shifts the oral microbiome in preschool children by reducing harmful bacteria (e.g., <em>Haemophilus)</em> while enriching beneficial species (e.g., <em>Streptococcus parasanguinis</em>). These findings suggest a potential role for fluoride toothpaste in caries prevention by promoting a healthier microbial balance, offering supportive evidence for its use in evidence-based pediatric dental care.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105941"},"PeriodicalIF":4.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production and biobanking of dental stem cells for clinical applications in regenerative dentistry: Current practices and future perspectives—A narrative review","authors":"Shuntaro Yamada ,&nbsp;Christoph Malkmus ,&nbsp;Elise Aasebø ,&nbsp;Kamal Mustafa ,&nbsp;Hiroshi Egusa ,&nbsp;Ana Angelova Volponi","doi":"10.1016/j.jdent.2025.105934","DOIUrl":"10.1016/j.jdent.2025.105934","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of the review was to map the current landscape of dental stem cell manufacturing practice and biobanking for clinical use and to identify variable factors that may hinder clinical translation and standardization of dental stem cell-based therapy.</div></div><div><h3>Data sources</h3><div>An electronic search was performed using Medline/PubMed, Web of Science, and Scopus, using “Dental stem cells” and “Dental pulp stem cells” as keywords. In addition, ClinicalTrials.gov was used to identify clinical trials of dental stem cells for therapeutic purposes. Relevant articles and bibliographic references from the reviewed studies were used to develop the narrative review.</div></div><div><h3>Study selection</h3><div>The initial search yielded 48 records from PubMed, 66 from Scopus, 33 from Web of Science, and 23 registered trials from ClinicalTrials.gov. In total, 23 registered trials were identified, of which 14 involved the therapeutic use of dental stem cells in clinical settings. For reviewing the current practices of dental stem cell manufacturing for clinical use, 20 studies were selected for an in-depth full-text analysis, among which fifteen and five articles addressed the <em>ex-vivo</em> expanding cells and chair-side preparation of micrograft containing dental stem cells, respectively.</div></div><div><h3>Conclusion</h3><div>Although dental stem cells have been applied in clinical settings for regenerative therapies, cell manufacturing practices have varied widely across reported cases, reflecting a lack of standardization. Furthermore, dental-specific challenges—such as logistical constraints and the complex involvement of multiple stakeholders—hinder compliance with stringent regulatory requirements, contributing to slower clinical translation compared to somatic-cell therapy medicine in other fields. This highlights a need for global collaboration among academia, industry, clinicians, and regulators to establish standardized practice, enhance predictability, and ensure long-term traceability.</div></div><div><h3>Clinical significance</h3><div>Dental stem cells have been used in clinical settings, with private practitioners playing a leading role in translating them into regenerative therapies in dentistry. This trend is expected to accelerate, driven by the growing number of enterprises entering the global dental stem cell biobanking market. Currently, cell manufacturing protocols vary widely across organizations with intricated regulatory framework applied. Furthermore, uncertainties remain regarding the use of long-term cryopreserved dental stem cells and the regulatory interpretation of such products.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105934"},"PeriodicalIF":4.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of printing parameters on the fabrication and fit accuracy of additively manufactured resin-based definitive three-unit fixed partial dentures","authors":"Mustafa Borga Dönmez ,&nbsp;Münir Demirel ,&nbsp;Almira Ada Diken Türksayar ,&nbsp;Burak Yilmaz","doi":"10.1016/j.jdent.2025.105937","DOIUrl":"10.1016/j.jdent.2025.105937","url":null,"abstract":"<div><h3>Objective</h3><div>To assess how build orientation and layer thickness affect the fabrication and fit accuracy (trueness and precision) of additively manufactured resin-based definitive fixed partial dentures (FPDs), comparing with subtractively manufactured FPDs.</div></div><div><h3>Methods</h3><div>Three-unit posterior FPDs were fabricated additively in a resin for definitive use (VarseoSmile Triniq) with varying build orientations (0-, 30-, 45-, 90-degree) and layer thicknesses (50, 100 µm) (AM0–50, AM0–100, AM30–50, AM30–100, AM45–50, AM45–100, AM90–50, and AM90–100) or subtractively in high-impact composite (breCAM.HIPC, SM-CR, control) (<em>n</em> = 6). Surface deviations (external, internal, marginal), fit (average gap), and their precision, which was the average of deviations from the mean deviation or gap values, were analyzed. AM FPDs were analyzed using a generalized linear model, while one-way analysis of variance with Dunnett’s test was used for comparisons with SM-CR FPDs (α = 0.05).</div></div><div><h3>Results</h3><div>Build orientation and layer thickness interaction affected the deviations and average gaps of AM FPDs, and build orientation affected marginal surface precision (<em>P</em> ≤ 0.044). AM30–50 and AM90–50 FPDs generally had lower deviations and average gaps, while 90-degree orientation resulted in lower marginal precision (<em>P</em> ≤ 0.020). AM30–50 and SM-CR FPDs had similar external and marginal deviations (<em>P</em> ≤ 0.370). AM90–50 FPDs had lower external deviations than SM-CR FPDs (<em>P</em> = 0.011). AM FPDs had higher intaglio deviations and average gaps than SM-CR FPDs (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>FPDs additively manufactured with 30- and 90-degree build orientation and 50-micron layer thickness had accuracy similar to SM-CR FPDs. However, SM-CR FPDs had better fit than AM FPDs.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105937"},"PeriodicalIF":4.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of antibacterial composite resin on salivary pH dynamics in high-caries-risk children: An ex-vivo study","authors":"Dora Schachter ,&nbsp;Nouran Aboraya-Khalayla ,&nbsp;Omer Enoch ,&nbsp;Sigalit Blumer ,&nbsp;Ervin I Weiss ,&nbsp;Michal Dekel Steinkeller","doi":"10.1016/j.jdent.2025.105933","DOIUrl":"10.1016/j.jdent.2025.105933","url":null,"abstract":"<div><h3>Objectives</h3><div>Composite resin restorations in primary teeth frequently fail due to secondary caries, which result from bacterial colonization and acid production at the tooth–restoration interface. This study aimed to evaluate whether composite resins containing quaternary ammonium silica (QASi), known for their antibacterial properties, can reduce bacterial acidification and lower the risk of secondary caries in high-caries-risk children compared to conventional restoratives.</div></div><div><h3>Methods</h3><div>Saliva samples (10 µL saliva, ∼10⁶ bacteria) from 34 high-caries-risk children were applied ex vivo directly to three restorative materials: (i) Infinix with 1.5% QASi (Nobio), (ii) Filtek Supreme (3 M), and (iii) amalgam (Silmet). Samples were incubated with growth media supplemented with 2.5% dextrose at 37 °C for 24 hours. Bacterial growth and pH decrease were measured, by turbidity and colour change, every 20 minutes. Controls included saliva alone and a blank polystyrene surface.</div></div><div><h3>Results</h3><div>Repeated-measures ANOVA showed Infinix had the slowest pH decline, followed by amalgam, while Filtek Supreme’s pH drop matched the control (p&lt;0.001). Infinix also exhibited the lowest bacterial growth rate (p&lt;0.001).</div></div><div><h3>Conclusion</h3><div>Saliva bacteria from high-caries-risk children exhibit significantly slower pH decrease on Infinix composite resins compared to conventional restoratives.</div></div><div><h3>Clinical significance</h3><div>Composite resins with quaternary ammonium silica (QASi) fillers effectively inhibit bacterial growth and acid production, helping to prevent secondary caries and enamel demineralization. These bioactive materials offer a promising solution for improving the longevity of restorations, especially in high-caries-risk pediatric patients.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105933"},"PeriodicalIF":4.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic cracked teeth: Associations with patient-level and tooth-level factors—A case-control study","authors":"Aidi Zhang ,&nbsp;Zhuping Sang ,&nbsp;Xige Zhang ,&nbsp;Yu Yang ,&nbsp;Zhe Yang ,&nbsp;Wei Wang","doi":"10.1016/j.jdent.2025.105921","DOIUrl":"10.1016/j.jdent.2025.105921","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate patient-level and tooth-level risk factors associated with symptomatic cracked teeth through a case-control study.</div></div><div><h3>Methods</h3><div>The case-control study included 100 symptomatic cracked tooth patients and matched controls. Patient-level (demographics and oral behaviors) and tooth-level parameters (type, location, crack location and cuspal inclination) were respectively assessed through questionnaires and clinical examinations. Univariate logistic regression analysis assessed the relationships between patient-level/tooth-level parameters and the occurrence of cracked teeth. Significant parameters (<em>p</em> ≤ 0.1) underwent multivariate analysis. Cuspal angles were compared using an independent samples <em>t</em>-test.</div></div><div><h3>Results</h3><div>The highest prevalence of cracked teeth occurred in individuals aged 30–39 years, predominantly affecting the maxillary first molar. Significant behavioral risk factors were hard food consumption and unilateral chewing. The tooth-related risk factors included dental caries, deep overbite, Angle's Class II malocclusion and Class I occlusal wear. Cracked teeth in maxillary first and second molars with four cusps were significantly associated with the inclination of the mesiobuccal, mesiolingual and distolingual cusps (<em>p</em> &lt; 0.05). This was also observed in the distobuccal cusp of maxillary second molars with three cusps (<em>p</em> &lt; 0.05). In mandibular first molars, cusp tilting was significantly associated with cracked teeth for all cusps except the distolingual cusp (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Eating hard food, unilateral chewing, dental caries, deep overbite, Class II malocclusion, wear and a steep cuspal inclination angle were all identified as potential risk factors for cracked teeth.</div></div><div><h3>Clinical significance</h3><div>The findings may facilitate the development of an effective and results-oriented prevention strategy for cracked teeth.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105921"},"PeriodicalIF":4.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}