Pellicle engineering with CaneCPI-5: a scoping review

IF 4.8 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-06-27 DOI:10.1016/j.jdent.2025.105939

João Victor Frazão Câmara , Anton Schestakow , Carolina Ruis Ferrari , Matthias Hannig , Marília Afonso Rabelo Buzalaf

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引用次数: 0

Abstract

Objectives

The salivary pellicle regulates interfacial processes on dental surfaces, offering protection against erosion and influencing bacterial adhesion. CaneCPI-5, a sugarcane-derived peptide inspired by cystatins, has been proposed as a cost-effective agent for pellicle modification. This scoping review evaluates the potential of CaneCPI-5 in pellicle engineering, particularly regarding erosion prevention and bacterial adhesion.

Data

Studies investigating the effects of CaneCPI-5 on pellicles formed by human saliva on enamel or dentin were included.

Sources

A literature search was conducted in Medline, Scopus, and Web of Science up to May 2025. Only English-language research articles were considered. Hand-searching, including checking reference lists, was not conducted.

Study selection

A total of 131 records were identified. After removing duplicates, the titles, abstracts and full-text were screened, resulting in 20 included studies. Most studies were conducted on enamel pellicles (n = 17), with some on dentin (n = 2) or both (n = 1). CaneCPI-5 demonstrated enamel-binding ability and modified the pellicle proteome by increasing acid-resistant proteins, enhancing resistance to erosion. Its effects on bacterial adhesion and caries prevention were inconsistent. Combinations with other agents, particularly vitamin E, showed synergistic effects, though overall findings were mixed.

Conclusions

CaneCPI-5 shows promise as a pellicle-modifying agent for erosion protection. However, current evidence is limited, and findings remain inconclusive, merit further research under clinically relevant conditions.

Clinical significance

Intentional modification of the pellicle with peptides like CaneCPI-5 may improve its protective properties and support preventive measures. Nonetheless, the long-term effects and clinical applicability of such modifications remain unclear. Further studies are needed to confirm their efficacy in the dynamic oral environment.

查看原文本刊更多论文

使用CaneCPI-5的膜工程：范围审查。

目的：唾液膜调节牙齿表面的界面过程，提供防止侵蚀和影响细菌粘附的保护。CaneCPI-5是一种受胱抑素启发的甘蔗衍生肽，被认为是一种具有成本效益的膜修饰剂。这篇综述评估了CaneCPI-5在膜工程中的潜力，特别是在防止侵蚀和细菌粘附方面。资料：研究了CaneCPI-5对人唾液在牙釉质或牙本质上形成的膜的影响。资料来源：在Medline， Scopus和Web of Science中进行了文献检索，截止到2025年5月。只考虑了英语研究文章。没有进行手工检索，包括检查参考书目。研究选择：共确定131份记录。在删除重复项后，对标题、摘要和全文进行筛选，最终纳入20项研究。大多数研究是针对牙本质（n = 2）或同时针对牙本质（n = 1）进行的（n = 17）。CaneCPI-5表现出搪瓷结合能力，并通过增加耐酸蛋白修饰膜蛋白组，增强抗侵蚀能力。其对细菌粘附和龋齿的预防效果不一致。与其他药物，特别是维生素E联合使用，显示出协同效应，尽管总体结果好坏参半。结论：CaneCPI-5是一种具有抗侵蚀作用的膜改性剂。然而，目前的证据有限，研究结果仍不确定，值得在临床相关条件下进一步研究。临床意义：用CaneCPI-5等多肽有意修饰细胞膜，可提高其保护性能，支持预防措施。尽管如此，这种改良的长期效果和临床适用性仍不清楚。需要进一步的研究来证实它们在动态口腔环境中的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.