Journal of dentistry最新文献

{"title":"A randomised controlled trial to evaluate the efficacy of a multi-step oral hygiene product intervention to improve oral health in partial denture wearers.","authors":"Joon Seong, Creeth Je, Burnett Gr, Sanchez E, Araga M, Nicola West","doi":"10.1016/j.jdent.2025.105643","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105643","url":null,"abstract":"<p><strong>Objectives: </strong>This study was designed to evaluate the effectiveness of a multi-step oral hygiene intervention among removal partial denture (RPD) wearers.</p><p><strong>Methods: </strong>A 12-week, single-blind, randomised, 2-armed, parallel-group, controlled trial was conducted with 49 RPD-wearing participants with mild-moderate gingivitis. The intervention group received stannous fluoride toothpaste, sodium fluoride mouth rinse, and an antibacterial denture cleanser foam. They were given detailed instructions on product usage. The control group continued with their usual oral hygiene regimen. Gingival health, denture cleanliness, and oral hygiene indices were assessed at baseline, 6, and 12 weeks.</p><p><strong>Results: </strong>48 participants completed the study, (one withdrawal due to concomitant medication). The intervention group reported 12.5% adverse events, with no events reported in the no-intervention group. Compliance rates were high for toothbrushing (99.4%), mouth rinse use (99.4%), and denture cleaning (99.3%). Significant improvements were observed for the intervention group in bleeding index, modified gingival index, and Turesky Plaque Index at both weeks 6 and 12 (p < 0.0001). Denture cleanliness also significantly improved, with lower Partial Denture Cleanliness Index scores at weeks 6 (p = 0.0039) and 12 (p < 0.0001). Overall, the intervention group showed consistently superior outcomes compared to the control, with significant differences in all plaque and gingivitis measures (p < 0.0001).</p><p><strong>Conclusion: </strong>This study highlighted the efficacy of a multi-step oral hygiene intervention in improving oral health outcomes among RPD-wearers with mild-moderate gingivitis. Findings from this study may inform evidence-based recommendations for optimal oral healthcare in this population, benefiting both patients and oral healthcare professionals.</p><p><strong>Clinical significance statement: </strong>This study demonstrated that a multi-step intervention, including three specific oral hygiene products and education, can significantly improve oral health outcomes for removable partial denture wearers with mild-moderate gingivitis. These findings offer practical insights for enhancing oral hygiene practices and gingival health in this patient population.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105643"},"PeriodicalIF":4.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival of endodontically treated teeth: A retrospective analysis of predictive factors at a German dental school.","authors":"Tina Rödig, Mai-Thanh Vu, Philipp Kanzow, Franziska Haupt","doi":"10.1016/j.jdent.2025.105662","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105662","url":null,"abstract":"<p><strong>Objectives: </strong>The aims were to investigate the survival rate of endodontically treated teeth (ETT) at a German dental school and to identify potential prognostic factors influencing tooth survival.</p><p><strong>Methods: </strong>Dental records of patients were retrospectively screened for nonsurgical root canal treatment of at least one permanent tooth between 2000 and 2015. Individual-, tooth-, and treatment-related variables were recorded, and survival was defined as the presence of the ETT in the oral cavity until the date of censoring. Survival rates of ETT were assessed by Kaplan-Meier statistics, and mean annual failure rates (mAFRs) after 5- and 10-years were calculated. The effect of the assessed variables on survival was determined by univariable log-rank test and multivariable Cox regression analysis with shared frailty (p<0.05).</p><p><strong>Results: </strong>Overall, 3,049 teeth from patients with a mean age of 41.53 ± 15.75 years were included. Survival of ETT after 5 and 10 years amounted to 88.0% and 77.4% (mAFR: 2.51% and 2.54%), respectively. The following variables significantly increased the tooth survival rate: patient age ≤ 60 years (p≤0.035), 2 proximal contacts (p<0.001), absence of apical periodontitis (p<0.001), multiple visits (p=0.033), use of a chelator (p=0.022), and placement of a new indirect restoration (p<0.001).</p><p><strong>Conclusion: </strong>Root canal treatment is effective for maintaining natural teeth. Tooth survival was affected by several individual-, tooth-, and treatment-related variables.</p><p><strong>Clinical significance: </strong>This retrospective study confirms the long-term retention of root-filled teeth after nonsurgical (re-)treatment. Several pre-, intra- and postoperative factors significantly reduced survival rates.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105662"},"PeriodicalIF":4.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the success of single-visit versus two-visit silver modified atraumatic restorative technique (SMART) in primary molars- a randomized controlled trial.","authors":"Dr Nidhi Sharawat, Dr Kalpana Bansal, Dr Vijay Prakash Mathur, Dr Nitesh Tewari, Dr Rahul Morankar, Dr Richa Mishra","doi":"10.1016/j.jdent.2025.105661","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105661","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the success of glass ionomer cement (GIC) restorations in carious primary molars using single-visit and two-visit silver modified atraumatic restorative technique (SMART).</p><p><strong>Methods: </strong>This was a parallel-group, two-arm randomized controlled trial conducted in a tertiary-care hospital. 150 children aged 4-9 years with asymptomatic carious lesions were recruited and randomized to one of the two interventions: single-visit and two-visit SMART. For each participant, a single tooth was selected to receive one of the interventions. Caries excavation was performed until firm dentin using hand instruments. In single-visit SMART, silver diamine fluoride (SDF) application, and GIC restoration were performed on the same visit while in the two-visit SMART, the GIC restoration was performed one week after the SDF application. Children were followed up at 6 and 12 months for the evaluation of restorations. The primary outcome was the success of the restoration at 12 months. Secondary outcomes were the proportions of failures (minor and major) in two groups. Fischer-exact test, logistic regression, and Kaplan-Meier curve were used for statistical analyses.</p><p><strong>Results: </strong>A total of 150 SMART restorations (single-visit=75, two-visit=75) were performed. At 12-months, 51 (68%) restorations in the single-visit group and 62 (82.7%) restorations in the two-visit group were evaluated as success (p=0.051). Minor failures were observed in 21 teeth (28%) in single-visit and 13 teeth (17.3%) in two-visit SMART. Major failures were noted only in single-visit SMART in 3 teeth (4.0%) (p=0.052).</p><p><strong>Conclusion: </strong>There was no statistically significant difference in the success rates of GIC restorations in single-visit and two-visit SMART groups.</p><p><strong>Clinical significance: </strong>Both single-visit and two-visit SMART restorations showed comparable success rates, thus clinicians can choose either protocol based on the patient's needs and cooperation.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105661"},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TMJ Pericapsular Guided Injection with Visual-Inertial Odometry (Augmented/Mixed Reality): a Novel Pilot Clinical Approach for Joint Osteoarthrosis Drug Delivery.","authors":"Marco Farronato, Roberta Crispino, Massimo Del Fabbro, Gianluca Martino Tartaglia, Niccolò Cenzato","doi":"10.1016/j.jdent.2025.105659","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105659","url":null,"abstract":"<p><strong>Introduction: </strong>Temporomandibular joint (TMJ) osteoarthrosis often requires pericapsular injections for symptom management. Image-guided techniques have demonstrated superior outcomes compared to traditional manual palpation. Augmented reality (AR) integrates digital images into the clinical scenario in real time and proved to be an efficient surgical guide. This pilot study evaluated the outcomes of AR-assisted versus manual palpation for polynucleotides (PN) pericapsular injections in subjects with TMJ osteoarthrosis.</p><p><strong>Materials and methods: </strong>20 condyles (10 patients) with bilateral TMJ osteoarthrosis were randomly assigned to either the test (N=10 condyles - 5 patients; 53 years old SD 13; 4 female - 6 male) or the control group (N=10 condyles - 5 patients; 58 years old SD 15; 5 female - 5 male): AR-guided or standard injection site localization following manual palpation. AR-guided injections employed custom visual-inertial odometry (VIO) algorithm, using the condyle's segmented images for precise injection site estimation. Mouth opening, lateral movements, and pain intensity were assessed at baseline (T0), 2 weeks (T1), 6 weeks (T2), 12 weeks (T3) post-injection. Statistical analysis included non-parametric Mann-Whitney test between groups for all the outcomes assessed.</p><p><strong>Results: </strong>AR-guided and manual palpation groups showed improvements in VAS scores and mandibular kinematics over time. The AR-guided group demonstrated significant pain reduction and increased lateral movement. There was no statistically significant difference between the two groups in terms of overall efficacy. The AR-guided procedure took approximately 120 seconds longer compared to manual palpation (mean time 343.8 sec and 211.2 sec).</p><p><strong>Conclusion: </strong>The new technique showed clinical efficacy and improvement trends in some clinical parameters such as VAS and laterality, with a reasonable increase in timing compared to the standard practice. This first application of AR can be considered for guided TMJ injections, but further research is needed.</p><p><strong>Clinical significance: </strong>AR-assisted TMJ injections offered improvements trends in VAS scores and lateral movements, making it a promising digitally guided approach for daily practice without the need of direct palpation.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105659"},"PeriodicalIF":4.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analog and digital complete denture bases accuracy and dimensional stability: an in-vitro evaluation at 24 hours and 6 months.","authors":"Alessio Casucci, Giulia Verniani, Bonadeo Giovanni, Sahin Fadil, Ferrari Marco","doi":"10.1016/j.jdent.2025.105658","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105658","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the accuracy of 3D printed complete denture bases compared to analog and milling manufacturing.</p><p><strong>Methods: </strong>Denture bases (n=60) were created using three methods: milling (n=10), analog (flasking) (n=10), and 3D printing (n=40). The 3D printing group was further divided into subgroups and each of the material groups. All samples were scanned, and their surfaces were analyzed using 3D software (Geomagic Control X software, 3D Systems) to compare them to the reference model. The accuracy was assessed using root mean square (RMS) values, reflecting the average deviation between the denture bases and the reference model.</p><p><strong>Results: </strong>At 24 hours, the \"Temp Print\", from 3D printing group had the lowest RMS values (54.20±9.44 µm), indicating higher accuracy, while the \"ProBase Hot\" from the anlog group showed the highest discrepancies, particularly in the border areas. Over six months, all groups experienced increased RMS values, with the 3d pronted \"Denture 3d+\" group showing the most significant variations (194.1±49.63 µm). The \"Temp Print\" group maintained the lowest RMS values, indicating better stability at 6 months.</p><p><strong>Conclusion: </strong>Despite some discrepancies, all denture bases remained within clinically acceptable limits (300 µm). Milled bases were the most stable between 24 hours and six months. In terms of accuracy and stability, 3D printed resins are suitable for both prototypes and definitive dentures. Further research is required to confirm the clinical acceptability of these materials.</p><p><strong>Clinical significance: </strong>Accuracy in the fabrication of denture bases is paramount for ensuring proper fit, function, and comfort for patients. Analog, addictive and subtractive manufacturing methods of production obtained good dentures accuracy.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105658"},"PeriodicalIF":4.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiofilm properties, cytotoxicity, and effect on protease activity of antibiotics and EGCG-based medications for endodontic purposes.","authors":"Daniela Alvim Chrisostomo, Jesse Augusto Pereira, Polliana Mendes Candia Scaffa, Zach Gouveia, Gabriel Flores Abuna, Sergey Plotnikov, Anuradha Prakki, Cristiane Duque","doi":"10.1016/j.jdent.2025.105660","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105660","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of two intracanal medications (IM) containing epigallocatechin-3-gallate (EGCG) with fosfomycin (FOSFO) and a triantibiotic combination of metronidazole, ciprofloxacin and fosfomycin (TRI), compared to controls calcium hydroxide (CH), all dissolved in polyethylene glycol 400 (PEG) on multispecies biofilms, fibroblast toxicity and on collagenolytic and gelatinolytic activities detected in radicular dentin.</p><p><strong>Methods: </strong>The antibiofilm effect and cytotoxicity of medications containing EGCG + FOSFO, TRI or CH were evaluated on multispecies biofilms formed in bovine root dentin specimens by confocal microscopy and on fibroblasts by resazurin assays, respectively. The inhibition of protease activity of each IM was evaluated by measuring collagenolytic enzyme activity by ELISA (Enzyme-linked immunosorbent assay) and gelatinolytic activity by metalloproteinases (MMPs) using in situ zymography in radicular dentin specimens.</p><p><strong>Results: </strong>PEG containing EGCG+FOSFO, PEG+TRI, and PEG+CH significantly reduced multispecies biofilms in radicular dentin tubules. At the concentrations tested, those IM were not toxic to fibroblasts. Additionally, all IM presented anti-collagenolytic activity by reducing telopeptide fragments released from radicular dentin compared to PEG carrier and water controls. In situ gelatinolytic activity, assessed via fluorescence levels, was significantly lower in radicular dentin adjacent to PEG containing CH, EGCG+FOSFO, or TRI compared to PEG and water controls.</p><p><strong>Conclusion: </strong>EGCG+FOSFO and TRI in PEG-400 exhibited antibiofilm, anti-collagenolytic and anti-gelatinolytic properties at concentrations that were non-toxic to fibroblasts, making them feasible intracanal medications for endodontic applications.</p><p><strong>Clinical significance: </strong>EGCG-based medications enhance the efficacy of endodontic treatment by providing antibiofilm, anti-collagenolytic, and anti-gelatinolytic properties, contributing to the preservation of root structure and improved treatment outcomes.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105660"},"PeriodicalIF":4.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring post-traumatic stress among patients at a clinic for orofacial pain and dysfunction.","authors":"Wendy Knibbe, Corine Mirjam Visscher, Frank Lobbezoo","doi":"10.1016/j.jdent.2025.105656","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105656","url":null,"abstract":"<p><strong>Objective: </strong>To explore the associations between traumatic events and post-traumatic stress on the one hand, and painful TMD, awake bruxism and sleep bruxism on the other.</p><p><strong>Methods: </strong>At a clinic for Orofacial Pain and Dysfunction, 701 patients completed self-report screening questionnaires between May 2023 and November 2024. On the basis of these data, we calculated descriptive characteristics, including the prevalence of PTSD. We tested our hypotheses using univariate and multivariate logistic regression analyses and Spearman's correlations and partial correlations.</p><p><strong>Results: </strong>The prevalence of PTSD (9.0%) was higher (p < .001) than the general population's prevalence (3.8%). The presence of PTSD was associated with the presence of painful TMD and awake bruxism. When no PTSD was present, there was no association between the three orofacial conditions and the experience of a traumatic event. Post-traumatic stress symptoms were significantly correlated to awake bruxism.</p><p><strong>Conclusion: </strong>The presence of PTSD in this clinical sample was associated with the presence of painful TMD and awake bruxism. The presence of a reported potentially traumatic event without PTSD was not associated with painful TMD or awake bruxism. Finally, when examining symptom severity, the severity of awake bruxism was correlated to post-traumatic stress symptoms.</p><p><strong>Clinical relevance: </strong>Increased knowledge about the role of post-traumatic stress in the aetiology of these orofacial conditions may enable tailoring treatment to these specific patient groups, and thus to increase the likelihood of treatment success.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105656"},"PeriodicalIF":4.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GASTROINTESTINAL CHOLECYSTOKININ SIGNALING PATHWAY DRUGS MODULATE OSTEOGENIC/CEMENTOGENIC DIFFERENTIATION OF HUMAN PERIODONTAL LIGAMENT STEM CELLS.","authors":"Catharina Marques Sacramento, Márcio Zaffalon Casati, Renato Correa Viana Casarin, Enilson Antonio Sallum, Karina Gonzales Silvério","doi":"10.1016/j.jdent.2025.105657","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105657","url":null,"abstract":"<p><strong>Objectives: </strong>Understanding the complexities of periodontal regeneration, particularly the unpredictable osteogenic/cementogenic differentiation of low-potential PDLSCs (LOP-PDLSCs), remains challenging. Identifying new therapeutic targets is crucial for enhancing regeneration. This study investigates the modulation of the Cholecystokinin (CCK) pathway, a key signaling cascade with roles in the gastrointestinal system, as a potential osteogenic/cementogenic pathway in PDLSCs.</p><p><strong>Methods: </strong>Gastrointestinal CCK-related drugs, Lorglumide and Sincalide, were tested for their effects on mineralization in PDLSCs. Lorglumide blocked the CCK pathway in high-potential PDLSCs (HOP-PDLSCs), while Sincalide enhanced mineralization in low-potential PDLSCs (LOP-PDLSCs). Cellular viability was tested under different drug concentrations, followed by a mineralization assay (AR-S) using non-toxic doses. RT-qPCR for osteogenic-related genes (IGF1, OCN, RUNX2) and CCK pathway-related genes (CCK, CCKAR, CCKBR, COX2, FOS, JNK3, RGS2) assessed gene modulation. Alkaline phosphatase (ALP) activity, Ca²⁺ quantification, and IP3 receptor phosphorylation were also evaluated.</p><p><strong>Results: </strong>Lorglumide reduced mineralization, ALP activity, and RUNX2, OCN, and IGF1 transcripts in HOP-PDLSCs (p<0.05). It decreased CCK and CCKAR expression, modulated COX2, FOS, JNK3, and RGS2 genes, reduced IP3 receptor phosphorylation, and lowered calcium levels (p<0.05). Conversely, Sincalide enhanced mineralization in LOP-PDLSCs, increasing ALP activity and OCN and IGF1 expression (p<0.05). It upregulated COX2, FOS, JNK3, and RGS2 genes, phosphorylated IP3 receptors in LOP1, and increased calcium levels in all LOP-PDLSCs (p<0.05).</p><p><strong>Conclusions: </strong>Sincalide and Lorglumide modulate PDLSCs' osteogenesis/cementogenesis, revealing the complex interplay of gastrointestinal drugs in periodontal tissue regeneration and offering insights for innovative therapies.</p><p><strong>Clinical significance: </strong>This study demonstrates the potential of gastrointestinal drugs targeting the CCK signaling pathway as innovative modulators for periodontal regeneration. By regulating osteogenic/cementogenic differentiation in hPDLSCs, these findings may pave the way for the development of novel biomaterials and therapies, promising improved outcomes in periodontal tissue regeneration for clinical applications.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105657"},"PeriodicalIF":4.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Microabrasion and a Remineralizing Agent Before In-office Bleaching on Hydrogen Peroxide Permeability, Color Alteration, and Enamel Morphology.","authors":"Michael Willian Favoreto, Leticia Condolo, Camila Mendes Camargo, Rafael Rodrigues Lima, Karol Carrillo, Abraham Lincoln Calixto, Alessandra Reis, Alessandro D Loguercio","doi":"10.1016/j.jdent.2025.105655","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105655","url":null,"abstract":"<p><strong>Objective: </strong>This in vitro study evaluated hydrogen peroxide (HP) penetration into the pulp chamber, bleaching efficacy, and surface enamel morphology of human teeth subjected to enamel microabrasion (MA) combined with in-office bleaching (IOB), with or without the application of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) remineralizing agent.</p><p><strong>Methods: </strong>Forty sound premolars were randomly divided into four groups: no treatment (NT), IOB only (IOB), MA followed by IOB (MA+IOB), and MA followed by CPP-ACP and then IOB (MA+CPP-ACP+IOB). HP concentration in the pulp chamber was measured using UV-Vis spectrophotometry, while bleaching efficacy was assessed with a digital spectrophotometer. Surface morphology was analyzed using scanning electron microscopy (SEM), and data were statistically analyzed.</p><p><strong>Results: </strong>The NT group exhibited lower HP penetration compared to experimental groups, while MA+IOB showed higher HP levels than IOB and MA+CPP-ACP+IOB. All experimental groups demonstrated significant color changes, except NT. The MA+IOB group displayed more grooves on enamel surfaces than the MA+CPP-ACP+IOB group, which had remineralizing agent deposits.</p><p><strong>Conclusion: </strong>Combining MA and IOB increases HP penetration into the pulp chamber, but using CPP-ACP after MA can mitigate this effect without compromising bleaching efficacy.</p><p><strong>Clinical significance: </strong>Employing a CPP-ACP remineralizing agent post-microabrasion can help reduce HP levels in the pulp chamber while maintaining effective whitening.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105655"},"PeriodicalIF":4.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing silver diamine fluoride delivery methods using microbrush, dental floss and Super Floss® on a tooth-to-tooth interproximal contact model.","authors":"Vanessa Yan Xiu Kwek, Catherine Hsu Ling Hong, Vinicius Rosa, Jing Li Lum, Kanglun Hong, Shijia Hu","doi":"10.1016/j.jdent.2025.105653","DOIUrl":"https://doi.org/10.1016/j.jdent.2025.105653","url":null,"abstract":"<p><strong>Objectives: </strong>Silver diamine fluoride (SDF) is an effective treatment for arresting caries, though its success for interproximal caries varies. This in vitro study aimed to evaluate the delivery of SDF to initial interproximal caries with three delivery methods using a tooth-to-tooth interproximal contact model.</p><p><strong>Methods: </strong>Extracted permanent premolars were randomly allocated to one of three experimental groups: microbrush, dental floss, Super Floss®, and two control groups. Randomly paired premolars were mounted on a tooth-to-tooth interproximal contact model and artificial carious lesions induced. SDF was delivered with the three delivery methods. The amount and successful delivery of SDF was evaluated with three proxy measures: percentage white spot lesion (WSL) area and depth stained with SDF, and percentage change in mineral density after remineralization.</p><p><strong>Results: </strong>Forty-two premolar pairs were included. The percentage of WSL area stained with SDF in the Super Floss® (93.05 ± 6.52) and dental floss (81.92 ± 20.15) groups were significantly (p < 0.001) higher than the microbrush (33.24 ± 39.01) group; the percentage of WSL depth stained with SDF in the Super Floss® (185.75 ± 51.61) group was significantly (p = 0.007) higher than the microbrush (52.07 ± 81.11) group. There was no difference in the mineral density percentage change between the three groups.</p><p><strong>Conclusion: </strong>Effectiveness of SDF delivery to interproximal caries was greatest with Super Floss®, followed by dental floss and then microbrush, with no significant differences between the floss groups. This study serves as a proof of concept prior to validating these methods in clinical settings.</p><p><strong>Clinical significance: </strong>In this in vitro study, SDF was delivered to initial interproximal caries most effectively using Super Floss®, followed by dental floss and then microbrush. Clinical studies are required to validate the results in clinical settings.</p>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":" ","pages":"105653"},"PeriodicalIF":4.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}