Journal of dentistry最新文献

{"title":"Nutritional status in non-cancer older adults experiencing dry mouth –meta-analysis and systematic review","authors":"Sanjana Santhosh Kumar ,&nbsp;Raquel Cantillo ,&nbsp;Xiuhui Xu ,&nbsp;Rachel Chacko ,&nbsp;Alhanoof Khaled Alarfaj ,&nbsp;Waldir Martineli Filho ,&nbsp;Abdul Basir Barmak ,&nbsp;Szilvia Arany","doi":"10.1016/j.jdent.2025.106071","DOIUrl":"10.1016/j.jdent.2025.106071","url":null,"abstract":"<div><h3>Objectives</h3><div>Older adults are at increased risk of nutritional deficiencies due to age-related physiological changes, chronic diseases, medication side effects, socioeconomic factors, and declining oral health. This systematic review examines the association between hyposalivation and nutritional status in non-cancer older adults.</div></div><div><h3>Data</h3><div>The study protocol was registered in PROSPERO (CRD42025645149). Data were extracted from eligible studies, and quality assessment and bias evaluation were conducted. Using a random effects model, a meta-analysis estimated the pooled prevalence of hyposalivation, xerostomia, and malnutrition.</div></div><div><h3>Sources</h3><div>A comprehensive search of PubMed, CINAHL, Web of Science, and Embase was performed from inception to December 2024.</div></div><div><h3>Study selection</h3><div>Longitudinal, cross-sectional, and case-control studies were included. After screening 774 potential studies, 14 (11 cross-sectional, two case-control, and one longitudinal cohort) met the inclusion criteria. Heterogeneity was assessed using Cochran's Q and I² statistics, while publication bias was evaluated with Egger's test and funnel plots.</div></div><div><h3>Conclusions</h3><div>Thirteen studies reported a significant association between hyposalivation and malnutrition in older adults. All studies highlighted impaired chewing, swallowing difficulties, and reduced taste sensitivity. The pooled prevalence of xerostomia was 38 % (95 % CI: 22–57 %) with substantial heterogeneity (I² = 97 %), while the estimated prevalence of malnutrition was 55 % (95 % CI: 34–74 %). The findings suggested a strong link between hyposalivation and malnutrition in non-cancer older adults. However, variability in study designs underscores the need for standardized diagnostic criteria and longitudinal studies to explore the interplay between salivary function and nutritional health in aging populations.</div></div><div><h3>Clinical significance</h3><div>This review highlights the association between hyposalivation and malnutrition in non-cancer older adults. Dry mouth impairs oral function, leading to poor nutrient intake and an increased risk of malnutrition. Early detection and management of hyposalivation are crucial to prevent nutritional problems. The variability in prevalence suggests a need for standardized diagnostic tools and further research to understand better nutritional health concerns associated with hyposalivation, as well as to improve patients' overall health and quality of life..</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106071"},"PeriodicalIF":5.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of thulium versus diode lasers in oral soft tissue surgery: a randomized clinical study","authors":"Li-Yuan Qi ,&nbsp;Jing Wen ,&nbsp;Qian Feng ,&nbsp;Jia-Sha Wang ,&nbsp;Ji Wang ,&nbsp;Hua Yu ,&nbsp;Yu Jin ,&nbsp;Jing Zhao ,&nbsp;Yi-Xiang Dai ,&nbsp;En-Cai Ji","doi":"10.1016/j.jdent.2025.106079","DOIUrl":"10.1016/j.jdent.2025.106079","url":null,"abstract":"<div><h3>Objectives</h3><div>To comprehensively compare and evaluate the relative effectiveness of thulium laser and diode laser in oral soft tissue surgery procedures.</div></div><div><h3>Methods</h3><div>Thirty-three participants who needed oral soft tissue surgery, encompassing frenectomy and gingivectomy, were recruited and subsequently randomized into two groups including 14 in the experimental group and 19 in the control group. The experimental group was treated with thulium fiber laser, while the control group was treated with the diode laser (980 nm). The coagulation efficacy following the surgery was assessed. The postsurgical pain level was recorded using visual analog scales 24 h, 48 h, 72 h and 240 h after the surgery. The effective healing rate were evaluated 10 days after surgery. The data were analyzed using the independent-samples t, Mann-Whitney U, and chi-square tests (α= 0.05).</div></div><div><h3>Results</h3><div>There were 14 cases (100 %) of Grade I hemostasis in the experimental group and 16 cases (84.21 %) in the control group, with a P-value &gt; 0.05 indicating no statistical difference. The mean pain score in the diode laser group were significantly higher than the corresponding values in the thulium laser group (<em>P</em> &lt; 0.05). Tukey’s test showed that the postsurgical pain level for the experimental group was significantly lower than that in control groups in 48 h (<em>P</em> &lt; 0.05) and 72 h (<em>P</em> &lt; 0.05) after surgery, and no statistical difference was found with the postsurgical pain level for the two groups in 24 h and 240 h after surgery. Within-group comparisons by ANOVA showed a significant difference in postsurgical pain level between the 4 time points in both groups (<em>P</em> &lt; 0.05). Both the experimental and control groups achieved 100 % effective healing rates, also with no statistical difference.</div></div><div><h3>Conclusions</h3><div>Thulium laser demonstrates no statistically significant differences in hemostasis effect and healing rate compared to 980 nm diode laser for oral soft tissue surgery. The use of thulium laser was associated with significantly lower pain score after surgery.</div></div><div><h3>Clinical Significance</h3><div>This work assessed the efficacy of thulium lasers in oral soft tissue surgery and discovered that they exhibit efficacy comparable to diode lasers with regard to hemostasis and wound healing. Moreover, thulium lasers demonstrate superior pain - management capabilities. The findings suggest that thulium lasers hold significant potential for application in oral medicine.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106079"},"PeriodicalIF":5.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocurcumin mediated photodynamic therapy as a novel approach for root canal disinfection: ex-vivo study","authors":"Nayrouz B. Soliman ,&nbsp;Sally A. Sabra ,&nbsp;Shahinda Rezk ,&nbsp;Nayera A. Mokhless ,&nbsp;Rania M. ElBackly","doi":"10.1016/j.jdent.2025.106075","DOIUrl":"10.1016/j.jdent.2025.106075","url":null,"abstract":"<div><h3>Background</h3><div>Antibacterial photodynamic therapy (aPDT) has been recommended to enhance root canal disinfection. Naturally derived photosensitizers have been suggested to enhance the effectiveness of aPDT.</div></div><div><h3>Aim</h3><div>To evaluate the in vitro characteristics, antibacterial activity and tubular penetration depth of nanocurcumin used as a photosensitizer for endodontic disinfection.</div></div><div><h3>Materials and Methods</h3><div>Nanocurcumin was prepared using sol-oil technique and characterized using ultraviolet visible spectrophotometry, zeta potential measurements, Fourier transform infrared spectroscopy, X-ray diffraction analysis and transmission electron microscopy. The antibacterial activity was assessed using well diffusion test and the minimum inhibitory concentration was determined. Single-rooted teeth were divided into 3 equal groups (n=6); group I (nanocurcumin modified aPDT), group II (curcumin modified aPDT) and group III (methylene blue conventional aPDT). Teeth were prepared and sectioned at 4, 8 and 12 mm from the root apices and examined under confocal laser scanning microscope to evaluate the tubular penetration percentage. Data were collected, tabulated and statistically analyzed using suitable tests.</div></div><div><h3>Results</h3><div>A pure form of nanocurcumin was prepared and characterized. There was no significant difference between nanocurcumin and curcumin neither in their antibacterial effect on <em>Enterococcus faecalis</em> (<em>p</em>=0.298) nor in their tubular penetration (<em>p</em>=0.662). Both nanocurcumin and curcumin showed significantly enhanced penetration when compared to methylene blue (<em>p</em>≤0.001).</div></div><div><h3>Conclusion</h3><div>Both nanocurcumin and curcumin, caused significantly higher tubular penetration compared with methylene blue, with no significant difference between them regarding antibacterial activity and penetration depth. Thus nanocurcumin could replace curcumin as a photosensitizer for its enhanced solubility and elimination of dimethyl sulfoxide as a solvent.</div></div><div><h3>Clinical significance</h3><div>Nanocurcumin can offer an effective environment-friendly photosensitizer for enhancing antibacterial photodynamic therapy for management of endodontic infections.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106075"},"PeriodicalIF":5.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cement application techniques on implant-supported single crowns","authors":"Hsiang Chih Yeh ,&nbsp;Xuedong Bai ,&nbsp;Yanning Chen ,&nbsp;James Kit Hon Tsoi","doi":"10.1016/j.jdent.2025.106062","DOIUrl":"10.1016/j.jdent.2025.106062","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the effect of different cement application techniques on weight of cement, cement film thickness, and retention force of cement-retained implant-supported single crowns.</div></div><div><h3>Material and methods</h3><div>Thirty-two samples comprising a titanium abutment analogue and a lithium disilicate crown were prepared and randomly divided into four groups. After surface pre-treatments, crowns were luted to abutment analogues with resin cement, adopting four application techniques: margin of crown (MA), brush on crown (BA), gross application on crown (GA), and pre-seating with chair-side copy abutment (CCA). Weight of cement used was recorded, while the cement film thickness was measured on digital files acquired by Micro-CT. Crown dislodging forces were assessed via the tensile test, after which failure modes were observed and analysed.</div></div><div><h3>Results</h3><div>CCA group (20.162 ± 2.385 mg) had a significantly lower cement usage than MA (26.149 ± 0.875 mg), BA (25.248 ± 0.644 mg), and GA (25.198 ± 1.226 mg) (<em>P</em> &lt; 0.001). BA (187.06 ± 23.77 µm) presented significantly higher cement film thicknesses than those using other application techniques (155.20 ± 13.44 µm for MA, 152.39 ± 25.32 µm for GA, and 135.73 ± 27.42 µm for CCA) (<em>P</em> <em>=</em> 0.047, 0.027, and &lt; 0.001, respectively). Four groups had comparable dislodging force with no significant difference on failure mode (<em>P</em> = 0.897).</div></div><div><h3>Conclusions</h3><div>Cement application techniques significantly influenced the weight of cement and cement film thickness on implant-supported single crowns, while the crown dislodging force was not affected. Based on the study result, CCA technique was recommended for cementing implant-supported crowns. A new model was developed for the retention test of anatomical crowns.</div></div><div><h3>Clinical Significance</h3><div>Cement-retained implant restorations are prone to complications induced by excess cement which can compromise clinical outcomes. The study evaluated the factor of cement application technique, proposing the CCA technique for its optimal balance in cement usage, crown retention, and clinical efficiency.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106062"},"PeriodicalIF":5.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation as a preventive strategy for oral mucositis in pediatric oncology: a systematic review and meta-analysis","authors":"Mariana Takatu Marques ,&nbsp;Lívia Trevelin Arêde ,&nbsp;João Victor Soares Rodrigues ,&nbsp;Wilton Mitsunari Takeshita ,&nbsp;Valdir Gouveia Garcia ,&nbsp;Rafael Scaf de Molon ,&nbsp;Letícia Helena Theodoro","doi":"10.1016/j.jdent.2025.106074","DOIUrl":"10.1016/j.jdent.2025.106074","url":null,"abstract":"<div><h3>Objectives</h3><div>Oral mucositis (OM) is one of the most frequent and debilitating complications in children undergoing treatment for hematologic malignancies. Current management strategies focus on minimizing OM severity and alleviating symptoms. This systematic review aimed to evaluate the effectiveness of photobiomodulation (PBM) in preventing OM in pediatric patients with hematologic malignancies receiving chemotherapy.</div></div><div><h3>Data/Sources</h3><div>Guided by the PICOS framework, this review addressed the following research question: Is PBM therapy effective in reducing the incidence and severity of oral mucositis in children and adolescents with hematologic malignancies undergoing chemotherapy? A comprehensive search was conducted in PubMed, Scopus, Web of Science, Embase and The Cochrane databases through February 2025. Eligible studies were randomized clinical trials involving patients aged 0–22 years diagnosed with hematologic malignancies treated by means of chemotherapy, and undergoing preventive PBM therapy for OM.</div></div><div><h3>Study Selection</h3><div>Five randomized controlled trials were included, encompassing patients aged 4 months to 22 years. Of these, 97 received low-level laser therapy (LLLT) and 80 received light-emitting diode therapy (LEDT). PBM was consistently reported as effective in preventing the onset and reducing the severity of OM in these populations. Three studies were eligible for meta-analysis, which demonstrated a statistically significant benefit of PBM therapy (<em>p</em> = 0.04), with a 95% confidence interval ranging from 0.01 to 0.84.</div></div><div><h3>Conclusions</h3><div>PBM therapy appears to be an effective preventive strategy for oral mucositis in pediatric patients undergoing chemotherapy for hematologic malignancies. Further large-scale trials are warranted to establish standardized protocols and optimize treatment outcomes.</div></div><div><h3>Clinical Significance</h3><div>PBM therapy significantly reduces the incidence and severity of oral mucositis in pediatric patients undergoing chemotherapy for hematologic malignancies. This non-invasive intervention offers an emerging preventive strategy, improving patient comfort and treatment adherence. Standardized PBM protocols may enhance supportive care in pediatric oncology settings.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106074"},"PeriodicalIF":5.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-assisted retrieval of cement-retained implant-supported restorations from implant abutments: A systematic review of related factors","authors":"Nareudee Limpuangthip ,&nbsp;Nan Hsu Myat Mon Hlaing ,&nbsp;Jae-Hyun Lee ,&nbsp;Jason D. Lee ,&nbsp;Sang J. Lee","doi":"10.1016/j.jdent.2025.106076","DOIUrl":"10.1016/j.jdent.2025.106076","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review aimed to synthesize and critically evaluate the existing evidence on factors influencing the performance of laser-assisted retrieval of cement-retained implant-supported dental restorations from implant abutments.</div></div><div><h3>Data sources</h3><div>PubMed/MEDLINE, Scopus, Embase, and Cochrane Library were searched until March 2025 without language restrictions, along with a manual search of references from relevant studies.</div></div><div><h3>Study selection</h3><div>Eligible studies included original research investigating laser-assisted removal or retrieval of implant-supported prostheses from abutments, considering variables related to cements, prosthetic materials, abutments, or laser parameters. Finally, seven in vitro studies were included. Risk of bias was assessed using the Checklist for Reporting In Vitro Studies. Outcomes included removal time, bond strength, temperature generation, and preservation of restoration and abutment structures.</div></div><div><h3>Conclusions</h3><div>The findings from this systematic review of in vitro studies indicate that laser-assisted retrieval of cement-retained implant restorations is influenced by multiple factors, including the type and thickness of restorative materials, cement characteristics, and laser power settings. Both erbium-doped yttrium aluminum garnet (Er:YAG) and erbium, chromium-doped yttrium scandium gallium garnet (Er,Cr:YSGG) lasers effectively retrieved restorations without causing structural damage due to thermal effects. Further clinical validation is recommended to establish optimal laser parameters, as these can affect retrieval efficiency and thermal generation.</div></div><div><h3>Clinical significance</h3><div>Available in vitro evidence suggests that Er:YAG and Er,Cr:YSGG lasers have potential for clinically efficient and safe retrieval of implant-supported restorations with minimal thermal damage, preserving ceramic restorations and abutments for reuse, reducing procedure time, avoiding unnecessary replacement, lowering costs, and improving prosthodontic efficiency.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106076"},"PeriodicalIF":5.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative clinical success of direct pulp capping materials: A network meta-regression of randomized clinical trials","authors":"Ömer Hatipoğlu ,&nbsp;Elif Varlı Tekingür ,&nbsp;Fatma Pertek Hatipoğlu","doi":"10.1016/j.jdent.2025.106073","DOIUrl":"10.1016/j.jdent.2025.106073","url":null,"abstract":"<div><h3>Objectives</h3><div>This systematic review and network meta-regression (NMR) aimed to evaluate and compare the clinical effectiveness of various direct pulp capping (DPC) materials used in permanent teeth, incorporating follow-up duration as a covariate.</div></div><div><h3>Materials and methods</h3><div>A comprehensive literature search was conducted across multiple databases, including PubMed, Cochrane Library, Scopus, and Web of Science, without language restrictions. Only randomized clinical trials comparing at least two DPC materials with a minimum follow-up of three months were included. Bayesian NMR analyses were performed to integrate direct and indirect evidence, providing odds ratios (OR) with 95 % credible intervals (CrIs) and prediction intervals (PI) while accounting for the follow-up duration.</div></div><div><h3>Results</h3><div>A total of 21 randomized controlled trials were included in the systematic review, of which 19 were eligible for the network meta-regression (NMR), comprising 1733 patients and six direct pulp capping materials. Biodentine (OR: 4.41; 95 % CrI: 1.40–17.66) and MTA (OR: 3.02; 95 % CrI: 1.19–8.30) demonstrated significantly higher clinical success compared to calcium hydroxide. SUCRA rankings placed Biodentine (83.1 %, 95 % CrI: 40–100) and MTA (66.6 %, 95 % CrI: 20–100) at the top, while calcium hydroxide had the lowest probability of success (18.2 %, 95 % CrI: 0–60).</div></div><div><h3>Conclusions</h3><div>Biodentine and MTA showed higher clinical success rates than calcium hydroxide in direct pulp capping of mature permanent teeth. However, due to substantial heterogeneity, wide credible intervals, and low certainty of evidence, no definitive conclusions can be drawn regarding the superiority of any material.</div></div><div><h3>Clinical significance</h3><div>Calcium silicate-based materials such as Biodentine and MTA are associated with higher clinical success in direct pulp capping compared to calcium hydroxide, suggesting they may offer more predictable outcomes in vital pulp therapy. However, due to limitations in the current evidence, including imprecision and study heterogeneity, clinicians should also consider factors such as handling properties, setting time, and restoration quality when selecting a pulp capping material. Long-term success may depend as much on restorative integrity as on the biological properties of the capping agent.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106073"},"PeriodicalIF":5.5,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of a novel 3D-printed zirconia single crown: A randomized controlled trial","authors":"Fangyuan Cai ,&nbsp;Yujie Wang ,&nbsp;Jimin Jiang,&nbsp;Weijie Wu,&nbsp;Hongye Lu,&nbsp;Tianning Ye,&nbsp;Yi Zhou ,&nbsp;Fuming He","doi":"10.1016/j.jdent.2025.106069","DOIUrl":"10.1016/j.jdent.2025.106069","url":null,"abstract":"<div><h3>Objectives</h3><div>This randomized controlled trial (RCT) aims to evaluate the clinical efficacy of Nano Particle Jetting (NPJ)-printed zirconia single crowns compared to Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM)-milled crowns over a 12-month follow-up period.</div></div><div><h3>Methods</h3><div>A total of 43 participants with 48 posterior teeth (vital or endodontically treated) were included. Randomization and allocation concealment were conducted using a computer-generated list and sealed envelopes, assigning 24 teeth to each group. Assessed parameters included the World Dental Federation (FDI) criteria as the primary outcome, Pink Esthetic Score (PES), White Esthetic Score (WES), periodontal parameters, and patient satisfaction.</div></div><div><h3>Results</h3><div>The FDI criteria showed no significant differences between NPJ-printed and CAD/CAM-milled crowns in aesthetic, functional, and biological parameters (<em>p</em> &gt; 0.05). NPJ-printed crowns demonstrated excellent marginal adaptation, achieving a clinical success rate of 95.8 % versus 91.6 % in the CAD/CAM group. One fracture was recorded in each group. No significant differences were demonstrated in most PES/WES and periodontal parameters (<em>p</em> &gt; 0.05). However, NPJ-printed crowns had a higher PES at baseline and 12-month follow-up visit (<em>p</em> = 0.02), and a statistically significant increase in plaque index was observed in CAD/CAM-milled crowns during the 6-month follow-up (<em>p</em> = 0.04). Patients in both groups reported a significant improvement in oral health-related quality of life (<em>p</em> &lt; 0.01) and maintained high levels of satisfaction (<em>p</em> &gt; 0.05).</div></div><div><h3>Significance</h3><div>This 12-month RCT demonstrates that NPJ-printed zirconia single crowns are clinically comparable to CAD/CAM-milled crowns, suggesting that NPJ printing could be a viable alternative for dental crown fabrication. Future research should focus on long-term follow-up studies to further validate these findings. (Registration number: ChiCTR2400089790)</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106069"},"PeriodicalIF":5.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An oral environmental responsive complex with mineralisation-antibacterial dual-activities for the prevention and treatment of early dental caries","authors":"Yu Wang ,&nbsp;Haowen Huang ,&nbsp;Sihan Qian,&nbsp;Chang Xu,&nbsp;Qingli Zhou,&nbsp;Chris Ying Cao","doi":"10.1016/j.jdent.2025.106068","DOIUrl":"10.1016/j.jdent.2025.106068","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop an oral environment-responsive complex with mineralisation-antibacterial dual-activities for preventing and treating early dental caries.</div></div><div><h3>Methods</h3><div>The complex was synthesized with phosphorylated starch serving as a template to stabilize calcium phosphate prenucleation clusters (CaP-PNCs) and silver nanoclusters (AgNCs). The binding properties of the complex on human enamel were evaluated using confocal laser scanning microscopy (CLSM). Antibacterial efficacy against <em>Streptococcus mutans</em>, including both planktonic bacteria and biofilms, was assessed through colony counting, scanning electron microscopy (SEM), and live/dead staining. Remineralization effects on artificially demineralized enamel were analyzed using SEM, CLSM, and energy-dispersive X-ray spectroscopy (EDS). Cytotoxicity on MC3T3 cells was tested using CCK-8 assays.</div></div><div><h3>Results</h3><div>The CaP-PNCs/AgNCs complex demonstrated strong binding to human enamel. In the presence of α-amylase, the complex exhibited potent antibacterial effects, achieving a 90% reduction in planktonic <em>Streptococcus mutans</em> viability and significantly disrupted biofilms. Remineralization assays showed a 70–100 μm hydroxyapatite layer resembling natural enamel in structure and composition. Notably, the complex maintained effective remineralization capabilities even under cariogenic bacterial challenge. Cytotoxicity evaluations on MC3T3 cells indicated no adverse effects on viability.</div></div><div><h3>Conclusion</h3><div>This complex enables targeted antibacterial action and biomimetic mineralization through responsively release of AgNCs and CaP-PNCs in oral environment, simultaneously addressing biofilm disruption and promoting enamel regeneration for the treatment of early caries.</div></div><div><h3>Clinical Significance</h3><div>The oral environmental responsive design provides a minimally invasive strategy to repair demineralized enamel while suppressing pathogenic biofilms, bridging non-invasive prevention and structural restoration in caries management.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106068"},"PeriodicalIF":5.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of incisor intrusion in adult female nonextraction deep overbite cases with clear aligner treatment","authors":"Xu Han ,&nbsp;Aohua Yang ,&nbsp;Yifei Hou ,&nbsp;Yi Liu","doi":"10.1016/j.jdent.2025.106070","DOIUrl":"10.1016/j.jdent.2025.106070","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the accuracy of incisor intrusion in nonextraction deep overbite cases in adult female patients treated with clear aligners (Invisalign, Align Tech, USA), and to investigate the predictability of clear aligner treatment for deep overbite correction.</div></div><div><h3>Methods</h3><div>This retrospective study included thirty-three adult female patients who underwent nonextraction followed by clear aligner treatment. The initial, predicted, and actual models were exported from ClinCheck. For nine completed cases, pre- and posttreatment cone-beam computed tomography (CBCT) data were collected. The amount of intrusion achieved for the incisors was measured, and the intrusion efficacy and deep overbite correction were calculated. Statistical analysis was performed using paired-samples t tests or Wilcoxon signed-rank tests (significance set at <em>P</em> &lt; 0.05), with effect sizes (Cohen's d) calculated for clinically meaningful differences and intraexaminer reliability assessed using the intraclass correlation coefficient (ICC).</div></div><div><h3>Results</h3><div>Significant differences were observed between the predicted and actual vertical movements of all teeth, with the greatest discrepancy observed in the maxillary central incisors. The average accuracy of intrusion for deep overbite correction in the first phase was 45.54 %. For the completed cases, the average correction for deep overbite was 41.18 %, which was comparable to the results achieved in the 1st phase (intital treatment stage).</div></div><div><h3>Conclusions</h3><div>In nonextraction adult female patients treated with clear aligners, the first phase demonstrated the most overbite correction with aligners, whereas additional refinement treatment did not significantly enhance the orthodontic outcome. Almost every patient with deep overbite required some degree of overcorrection and further refinement treatments to achieve optimal results.</div></div><div><h3>Clinical Significance</h3><div>This study aimed to i) evaluate the accuracy of incisor intrusion with deep overbite correction over several refinements, ii) determine the discrepancy of individual teeth in vertical movements in the different phases of the aligners, and iii) assess the predictability of clear aligners for deep overbite correction.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"163 ","pages":"Article 106070"},"PeriodicalIF":5.5,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}