Journal of dentistry最新文献

{"title":"Sensitive periods for the association between smoking initiation and later oral health-related quality of life","authors":"Leandro Machado Oliveira ,&nbsp;Natanael Machado de Oliveira ,&nbsp;Andressa Trindade Walter ,&nbsp;Thayná Regina Pelissari","doi":"10.1016/j.jdent.2025.105893","DOIUrl":"10.1016/j.jdent.2025.105893","url":null,"abstract":"<div><h3>Aim</h3><div>To examine the association between the age of smoking initiation (SI) and oral health-related quality of life (OHRQoL) in individuals aged 50 and older.</div></div><div><h3>Methods</h3><div>This secondary analysis utilised data from never and current smokers (N = 7153 complete cases) participating in the second wave of the Brazilian Longitudinal Study of Ageing (ELSI-Brazil 2019–2021), a nationally representative cohort of community-dwelling individuals aged 50 years and over. OHRQoL was assessed using the Oral Impacts on Daily Performance (OIDP) questionnaire. Adjusted zero-inflated negative binomial regression models were employed to estimate mean ratios (MRs) for the association between the age of SI and overall OIDP scores.</div></div><div><h3>Results</h3><div>Compared to never smokers, individuals who initiated smoking at ages 15–19, 10–14, and 5–9 years exhibited 29 % (95 % CI: 1.10, 1.51), 28 % (95 % CI: 1.06, 1.55), and 46 % (95 % CI: 1.12, 1.90) higher OIDP mean scores, respectively. After adjusting for pack-year smoking history, only the association for those who started smoking at ages 5–9 years remained significant (MR = 1.44; 95 % CI: 1.06, 1.96).</div></div><div><h3>Conclusion</h3><div>SI at childhood and adolescence is associated with poorer OHRQoL later in life. The association observed in individuals who started smoking between ages 5 and 9 appears to be independent of the cumulative smoking exposure.</div></div><div><h3>Clinical significance</h3><div>Early childhood represents a sensitive period during which SI has enduring adverse effects on oral health in later life. Tobacco control policies should prioritise early-life interventions to mitigate long-term oral and systemic health risks.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105893"},"PeriodicalIF":4.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effect of natural polyphenols on recombinant and endogenous dentinal proteases","authors":"Yingheng Liu ,&nbsp;Hongye Yang ,&nbsp;Kaiyu Qiu ,&nbsp;Kang Li ,&nbsp;Jian Yu ,&nbsp;Chenmin Yao ,&nbsp;Cui Huang","doi":"10.1016/j.jdent.2025.105895","DOIUrl":"10.1016/j.jdent.2025.105895","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the effects of four natural polyphenols on recombinant and endogenous proteases, and to explore their potential mechanisms.</div></div><div><h3>Methods</h3><div>The interaction of natural polyphenols, namely proanthocyanidins (PA), epigallocatechin-3-gallate (EGCG), quercetin (QUE), and resveratrol (RES) with dentin matrix was observed using SEM. The inhibitory effects of natural polyphenols and the control chlorhexidine (CHX) on matrix metalloproteinases 2 and 8 (MMP-2 and MMP-8) were assessed using fluorometric assay kits. Bacterial collagenase activity was measured by analyzing the loss of dry mass and released hydroxyproline. In situ zymography (ISZ) was conducted to determine matrix-bound protease activity. Furthermore, <em>in silico</em> molecular docking simulations were performed to investigate the interactions between natural polyphenols and proteases.</div></div><div><h3>Results</h3><div>SEM observation demonstrated the collagen-protective effects of four natural polyphenols against collagenase digestion. However, only PA showed a performance comparable to CHX group on both recombinant MMP-2 and MMP-8. Concerning bacterial collagenase, PA and EGCG exhibited superior inhibitory effects compared to QUE and RES (<em>p</em> &lt; 0.05). The fluorescence intensity of ISZ indicated stronger suppression of endogenous protease activity in the PA and EGCG groups than in the QUE and RES groups. Molecular docking analysis consistently showed that PA and EGCG had higher binding affinities for both MMP2 and MMP8 than QUE and RES.</div></div><div><h3>Conclusion</h3><div>Natural polyphenols can deactivate both soluble and matrix-bound proteases, the stronger inhibitory effect may be attributed to the formation of more hydrogen bonds.</div></div><div><h3>Clinical significance</h3><div>Natural polyphenolic protease inhibitors with more hydroxyphenyl radicals could potentially enhance anti-proteolytic performance and bonding durability.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105895"},"PeriodicalIF":4.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of multi-stacking and resin type on dimensional stability of dentate casts","authors":"Mustafa Borga Dönmez ,&nbsp;Gabriel Willauer ,&nbsp;Münir Demirel ,&nbsp;Çiğdem Kahveci ,&nbsp;Burak Yilmaz","doi":"10.1016/j.jdent.2025.105871","DOIUrl":"10.1016/j.jdent.2025.105871","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effects of multi-stacking and resin type on the dimensional stability of additively manufactured (AM) dentate casts.</div></div><div><h3>Methods</h3><div>A master maxillary dentate model file was used to AM casts in a multi-stacked manner, consisting of four layers (L1–L4), using two different resins (DentaMODEL [DM] and KeyModel Ultra Ivory [KM], <em>n</em> = 10). Each cast was digitized one day, one week, two weeks, three weeks, four weeks, and three months after fabrication (T0–T5). The scan files were superimposed over the master file to evaluate the dimensional stability of the casts (anterior, posterior, and entire arch) using the root mean square method. Data were analyzed with a generalized linear model (α = 0.05).</div></div><div><h3>Results</h3><div>KM casts had their highest anterior and entire arch deviations when printed at L4 (<em>P</em> &lt; 0.001). DM casts mostly had lower deviations than KM casts across tested layers and storage durations (<em>P</em> &lt; 0.001). DM casts showed the highest anterior deviations at T1 and T2, while KM casts showed the highest at T0, T3, and T4 (<em>P</em> ≤ 0.009). Casts printed at L4 showed the highest anterior deviations at T0 and greater deviations than L1 at T3 and T5, regardless of resin (<em>P</em> ≤ 0.044). KM casts had lower entire arch deviations at T5 than at T3 (<em>P</em> = 0.027).</div></div><div><h3>Conclusions</h3><div>While the differences due to stacking were minimal and clinically negligible, the DM casts mostly had higher stability. All casts remained within clinically acceptable limits over three months.</div></div><div><h3>Clinical Significance</h3><div>Multi-stacking during printing may be an efficient method for large-scale of plateless dentate casts with clinically acceptable dimensional stability for diagnostic and orthodontic use over three months, when tested resins and three-dimensional printer are used.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105871"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the digestive enzyme pepsin on enamel erosion and the protective efficacy of surface pre-reacted glass-ionomer particle gel","authors":"Mayron Guedes Silva ,&nbsp;Klícia Kallynne Cutrim Sousa ,&nbsp;Alan Silva de Menezes ,&nbsp;Leily Macedo Firoozmand","doi":"10.1016/j.jdent.2025.105890","DOIUrl":"10.1016/j.jdent.2025.105890","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate in vitro the impact of pepsin on enamel erosion in the presence of an acquired pellicle and assess the protective efficacy of a bioactive gel containing surface pre-reacted glass-ionomer (S-PRG) particles by measuring surface hardness loss.</div></div><div><h3>Methods</h3><div>Bovine enamel blocks were prepared, standardized, and randomly assigned to two groups (<em>n</em> = 24/group): HCl-only erosive model and HCl+Pep – an erosive model with pepsin. Each group was further divided into two pre-treatment conditions (<em>n</em> = 12/group): SPRG (exposure to S-PRG bioactive gel) and DW (immersion in deionized water, control). Baseline enamel superficial microhardness was measured. Acquired pellicle was formed using human saliva and the samples were subjected to an erosive challenge for 9 days. Surface hardness loss (%SHL), morphological and mineral composition changes (scanning electron microscopy [SEM]/energy-dispersive X-ray spectroscopy), and crystal characteristics (X-ray diffraction [XRD]) were analyzed. Statistical analysis was performed using one-way analysis of variance (<em>p</em> &lt; 0.05).</div></div><div><h3>Results</h3><div>The HCl+Pep group exhibited significantly higher %SHL than the HCl-only group (<em>p</em> &lt; 0.001). Pre-treatment with S-PRG gel did not significantly reduce %SHL (<em>p</em> &gt; 0.05). SEM images revealed severe mineral loss in the interprismatic regions of the HCl+Pep/DW group, whereas the HCl/SPRG group exhibited less degradation. XRD analysis indicated modifications in hydroxyapatite (HAp) microstructure, with the formation of octacalcium phosphate, in the HCl/SPRG.</div></div><div><h3>Conclusions</h3><div>Pepsin exacerbates enamel erosion by increasing %SHL and altering the morphology and structural pattern of HAp crystals. Although S-PRG gel pre-treatment did not prevent %SHL, it facilitated the formation of a new crystalline phase and reduced enamel degradation.</div></div><div><h3>Clinical significance</h3><div>Pepsin exacerbates enamel erosion by intensifying mineral loss despite the acquired pellicle. Although it does not prevent hardness loss, bioactive materials are emerging as a promising supportive strategy - minimizing surface degradation through possible crystal structure modification, particularly in gastroesophageal reflux-related erosion conditions.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105890"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of at-home bleaching agents and concentrations on tooth sensitivity: A systematic review and network meta-analysis","authors":"Renata Maria Oleniki Terra ,&nbsp;Michael Willian Favoreto ,&nbsp;Tom Morris ,&nbsp;Alessandro D. Loguercio ,&nbsp;Alessandra Reis","doi":"10.1016/j.jdent.2025.105891","DOIUrl":"10.1016/j.jdent.2025.105891","url":null,"abstract":"<div><h3>Introduction/objectives</h3><div>This systematic review and network meta-analysis (NMA) evaluated the risk and intensity of tooth sensitivity (TS) of at-home bleaching agents and concentrations in patients with permanent dentition (PROSPERO 2021 CRD42021265220).</div></div><div><h3>Data</h3><div>Randomized clinical trials (RCTs) comparing any two at-home bleaching systems were considered eligible. A Bayesian NMA assessed TS risk and intensity for different hydrogen peroxide (HP) and carbamide peroxide (CP) concentrations, using two pain scales: the 0–10 Visual Analog Scale (VAS) and the 0–4 Numerical Rating Scale (NRS). The risk of bias (RoB) was assessed using the Cochrane Collaboration’s tool 2.0, and the quality of evidence (QoE) was evaluated by the GRADE approach.</div></div><div><h3>Sources</h3><div>A comprehensive search was conducted in PubMed, Cochrane Central, LILACS/BBO, SCOPUS, Web of Science, EMBASE, and grey literature.</div></div><div><h3>Study selection/results</h3><div>77 studies were included, and 50 of these were eligible for meta-analysis. Most studies had high RoB. The NMA showed a higher TS risk with CP 20–22 % and HP 14–16 % compared to HP 2–4 % (RR [95 % CrI]: 2.8 [1.15–8.16], 2.9 [1.06–9.21]) and CP 20–22 % vs. CP 10–11 % (2.0 [1.07–4.31]). On the NRS scale, CP 20–22 % (MD [95 % CrI]: 0.51 [0.14–0.91]) and HP 7–8 % (0.50 [0.10–0.84]) had greater TS intensity than CP 10–11 %. No statistically significant differences were found on the VAS scale. The QoE was low.</div></div><div><h3>Conclusions</h3><div>High at-home bleaching concentrations increase the risk and intensity of TS. On average, TS is mild for all bleaching agents and concentrations. The findings should be interpreted cautiously due to the low QoE and variability in the study protocols.</div></div><div><h3>Clinical significance</h3><div>At-home bleaching agents typically cause low tooth sensitivity. However, higher concentrations, such as HP 14–16 % and CP 20–22 %, may slightly increase the risk compared to lower concentrations like CP 10 %, and should be prescribed with care and under closer supervision.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105891"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the readiness of dental electronic health records for machine learning prediction of procedure outcomes: Insights from the bigmouth repository on composite and amalgam restoration survival rates","authors":"Hend Alqaderi ,&nbsp;Hesham Alhazmi ,&nbsp;Lauren Gritzer ,&nbsp;Narjes Bencheikh ,&nbsp;Mary Tavares ,&nbsp;Jay Patel ,&nbsp;Athanasios Zavras","doi":"10.1016/j.jdent.2025.105865","DOIUrl":"10.1016/j.jdent.2025.105865","url":null,"abstract":"<div><h3>Objective</h3><div>Dental electronic health records (EHRs) often lack comprehensive data for evaluating procedure outcomes. Machine learning (ML) enables predictive modeling but its applicability to dental EHR data remains unclear. This study assessed the readiness of dental EHRs for predicting restoration failure using classical and ML models.</div></div><div><h3>Methods</h3><div>Data from the BigMouth Dental Data Repository was analyzed, focusing on posterior restorations in permanent molars of vital teeth. Failure was defined as root canal treatment or extraction within five years. Predictors included restoration type, caries depth, number of surfaces filled, time to failure, age, and gender. Cox proportional hazards analysis and ML models compared amalgam and composite restorations.</div></div><div><h3>Results</h3><div>A total of 21,510 restorations placed between 2011 and 2020 across nine universities were identified. Both classical and ML analyses indicated superior five-year survival for composite restorations. Classic survival analysis showed a higher failure rate for amalgam (8.84 %) compared to composite (4.36 %). Among ML survival models, Cox Proportional Hazards (Cox pH), Random Survival Forest (RSF), and DeepSurv, Cox pH had the highest Concordance Index (C-Index) at 0.64, while RSF and DeepSurv both achieved 0.63. RSF recorded the highest Time-Dependent Area Under Curve (0.620). Age, restoration type, and number of surfaces filled were the most significant predictors of restoration survival.</div></div><div><h3>Conclusion</h3><div>Our findings demonstrate that dental EHRs, in their current state, are not yet equipped to support accurate assessment and prediction of restoration failure. ML models achieved only moderate predictive performance, largely due to the absence of key clinical variables necessary for precise evaluation.</div></div><div><h3>Clinical Significance</h3><div>Gaps in dental EHR data limit the accuracy of ML-based risk prediction. Enhancing diagnostic coding and data standardization can improve predictive modeling, support evidence-based decision-making, and optimize treatment planning. Strengthening EHR documentation will enable Artificial Intelligence-driven tools to enhance clinical outcomes and advance precision dentistry.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105865"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised, controlled, trial investigating the effect of tooth brushing with a sodium bicarbonate toothpaste for 12 weeks compared to a conventional fluoride toothpaste on gingivitis","authors":"Nicola X. West ,&nbsp;Jianhong Qiu ,&nbsp;Alexander J. Pollard ,&nbsp;Maria Davies ,&nbsp;Gary Smith ,&nbsp;Paola Gomez-Pereira ,&nbsp;Joon Seong","doi":"10.1016/j.jdent.2025.105886","DOIUrl":"10.1016/j.jdent.2025.105886","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine the effect on gingival inflammation of toothbrushing with sodium bicarbonate toothpaste for 12 weeks compared to brushing with a conventional fluoride toothpaste.</div></div><div><h3>Methods</h3><div>An ethically-approved, single-centre, controlled, examiner-blind, randomized, two-treatment arm, parallel study in consenting healthy ≥18yr participants with ≥20 teeth diagnosed with localised gingivitis. Approximately 200 eligible participants brushed for 2weeks with a fluoride acclimatization toothpaste before randomization to brushing 2/daily with a sodium bicarbonate (test) or fluoride (control) toothpaste. No pre-prophylaxis was conducted prior to study start. Modified gingival index (MGI), bleeding index (BI) and Turesky plaque index (TPI), were measured at baseline, 3, 6 and 12weeks. Participants completed a diary for compliance monitoring.</div></div><div><h3>Results</h3><div>190 participants were randomised, 188 completed the study. The test group demonstrated a statistically significant reduction in number of bleeding sites from baseline to 12-weeks (<em>p</em> = 0.0032), 6-weeks (<em>p</em> = 0.0031) and 3-weeks (<em>p</em> = 0.0091), and compared to control group from baseline to 12-weeks (<em>p</em> = 0.0013). The test group showed significantly (all <em>p</em> &lt; 0.0001) decreased mean MGI score from baseline to 3-weeks, 6-weeks, and 12-weeks compared to control group; significantly decreased mean overall TPI score from baseline to 3-weeks (<em>p</em> = 0.0012), 6-weeks (<em>p</em> = 0.0058), and 12-weeks (<em>p</em> &lt; 0.0001) compared to control; and significantly reduced mean interproximal TPI scores compared to control group from baseline to 3-weeks (<em>p</em> = 0.0022), 6-weeks (<em>p</em> = 0.0099) and 12-weeks (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>Twice daily toothbrushing with a sodium bicarbonate toothpaste significantly improved oral health reducing localised gingivitis compared to brushing with a conventional fluoride toothpaste, measured by BI, MGI and TPI over 12 weeks.</div></div><div><h3>Clinical Significance</h3><div>Localised, gingivitis can be resolved or prevented with excellent home-use oral hygiene measures, but this is rarely achieved with mechanical brushing alone. Twice daily toothbrushing with sodium bicarbonate toothpaste demonstrated added value in reducing localised gingivitis and improving oral health compared to brushing with a conventional fluoride toothpaste.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105886"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of bone dimensional stability after two-stage maxillary sinus floor augmentation with autogenous bone versus bovine bone mineral combined with autogenous bone chips: results from a 1-year multicenter split-mouth randomized controlled trial","authors":"Isabella Neme Ribeiro dos Reis ,&nbsp;Anouck Jue ,&nbsp;Eppo Wolvius ,&nbsp;Justin Pijpe ,&nbsp;Rubens Spin-Neto ,&nbsp;Ronald Ernest Jung ,&nbsp;Nadja Naenni ,&nbsp;Franz J. Strauss ,&nbsp;Brend Jonker","doi":"10.1016/j.jdent.2025.105889","DOIUrl":"10.1016/j.jdent.2025.105889","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the dimensional stability of augmented bone following maxillary sinus floor augmentation (MSFA) using autogenous bone (AB) alone or bovine bone mineral combined with locally harvested AB chips (BBM), one year after implant loading.</div></div><div><h3>Material and methods</h3><div>A secondary analysis of a split-mouth, multicenter randomized controlled trial was conducted among 20 patients (40 implants). CBCT/CTs were used to measure bone height (buccal and palatal aspects) and bone area at the implant center at two time points: before implant placement (4–6 months post-MSFA, T1) and 12 months post-implant loading (T2). Residual bone height and sinus width at 1, 5, and 10 mm from the crest were also recorded. Linear regression models with generalized estimating equations were used to assess the influence of graft material (AB and BBM), initial graft dimensions and sinus width on dimensional changes.</div></div><div><h3>Results</h3><div>Adjusted regression models showed that AB-treated sites experienced significantly greater reductions in graft height (mean difference at buccal sites: -1.76 mm [95 % CI, -0.86 to -2.65]; p-value = &lt;0.001); mean difference at palatal sites: -1.82 mm [95 % CI -0.75 to -2.88]; <em>p</em> = 0.001; and bone area (mean difference –17.80 mm² [95 % CI –6.61 to –28.99]; <em>p</em> = 0.002) compared to BBM. Greater initial graft height and area were associated with reduced dimensional changes (<em>p</em> &lt; 0.001) especially when using BBM. Sinus width, measured 10 mm from the crest, was modestly but significantly associated with changes in bone height (<em>p</em> = 0.020), but not with changes in bone area (<em>p</em> = 0.147).</div></div><div><h3>Conclusion</h3><div>MSFA using BBM combined with autogenous bone chips resulted in greater dimensional stability compared to AB alone.</div></div><div><h3>Clinical implications</h3><div>BBM combined with autogenous bone chips better preserved graft dimensions than AB alone.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105889"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of preparation design and build orientation on the accuracy of ceramic-filled composite veneers printed using Tilted Stereolithography technology. An in vitro study","authors":"Reham B Osman ,&nbsp;Nawal M. Alharbi","doi":"10.1016/j.jdent.2025.105875","DOIUrl":"10.1016/j.jdent.2025.105875","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the influence of preparation design, build orientation and interaction between these two factors on the accuracy of veneers 3D printed using tilted stereolithography technology (TSLA).</div></div><div><h3>Methods</h3><div>Three maxillary central incisor typodont models were prepared to receive a full veneer preparation with three finish line designs: Cl I; labial reduction, Cl II; labial with butt joint incisal reduction and Cl III; labial and incisal overlap design then digitized to design the restorations which were 3D-printed using ceramic filled composite material (Dfab; DWS)(IrixMax monochrome A2; DWS)(<em>N</em> = 90). In each group, three subgroups were defined based on the build orientation (<em>N</em> = 10): 90°, 75° and 45° angles. Accuracy was evaluated using metrology software. Two-way Analysis of Variance (ANOVA) test was used to detect the differences between the groups (α=0.05).</div></div><div><h3>Results</h3><div>Two-way ANOVA revealed a statistically significant interaction between different build angles and preparation design on RMSE trueness values (<em>P</em> = .003) and RMSE precision values (<em>P</em> = .001) Tukey post hoc test revealed that Cl II design had significantly lower RMSE values compared to both Cl I and Cl III designs (<em>P</em>&lt;.001). 45° angle revealed significantly higher RMSE values compared to 75° and 90° build angles with <em>P</em> values .017 and .009 respectively.</div></div><div><h3>Conclusions</h3><div>Both preparation design and build orientation have an influence on the accuracy of TSLA printed laminate veneers. Butt-joint preparation design exhibited highest trueness compared to both window and incisal wrap designs. Among all finish line designs, 45° build angle exhibited the most significant deviation values and is not recommended for printing veneers using TSLA technology.</div></div><div><h3>Clinical Significance</h3><div>The preparation design that best fits a given clinical situation should be selected. The print angle that yields the highest accuracy relative to the clinically selected and executed tooth preparation design should be chosen. With different veneer preparation designs, 45° build angle provides the highest deviation values with chairside TSLA printers and should be avoided when printing resin-based, monochromatic laminate veneers.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"161 ","pages":"Article 105875"},"PeriodicalIF":4.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ex vivo study on the correlation between lesion size and resin infiltration area in natural proximal subsurface carious lesions deproteinized with sodium hypochlorite","authors":"Ina B. Ulrich ,&nbsp;Markus Pasztorek ,&nbsp;Wilhelm Frank ,&nbsp;Andrej M. Kielbassa","doi":"10.1016/j.jdent.2025.105858","DOIUrl":"10.1016/j.jdent.2025.105858","url":null,"abstract":"<div><h3>Objective</h3><div>This <em>ex vivo</em> study investigated the effects of pre-treatment either with or without a deproteinization procedure using a sodium hypochlorite (NaOCl) solution on percentage resin infiltration in natural non-cavitated proximal subsurface carious lesions of (pre)molars. Moreover, we studied whether a correlation exists between lesion size and infiltration area.</div></div><div><h3>Methods</h3><div>Extracted human premolars and permanent molars (<em>n</em> = 40 each) with macroscopically non-cavitated proximal subsurface carious lesions (ICDAS code 2/radiographic E2 and D1 lesions) were randomly divided into two groups. In Group 1 (control), the carious lesions underwent a standard resin infiltration protocol (deploying 15 % hydrochloric acid, 99 % ethanol, and Icon Caries Infiltrant). With the specimens of Group 2, a deproteinization step using 1 % NaOCl was applied prior to the standard infiltration procedure. Teeth were sectioned mesio-distally (perpendicular to their occlusal tooth surface and through the proximal lesion) and polished to the deepest lesion extension (as defined by DIAGNOdent). Total lesion sizes and infiltration areas were analyzed via confocal laser scanning micrographs. Paired data were submitted to linear regression analysis employing SPSS (v29.0).</div></div><div><h3>Results</h3><div>With the deproteinized specimens (Group 2), a significantly higher percentage of resin infiltration (<em>p</em> = .003) was observed, along with a strong positive correlation between lesion size and infiltrated area (<em>r</em> = .97; <em>p</em> &lt; .001), if compared to Group 1 (<em>r</em> = .89; <em>p</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Deproteinization with NaOCl prior to resin infiltration significantly enhances the infiltrant’s penetration ability into non-cavitated carious lesions, resulting in a strong relationship between lesion size and infiltrated area.</div></div><div><h3>Clinical significance</h3><div>Deproteinization by means of NaOCl solution should be implemented as an integral step and key component to the standard infiltration protocol to significantly improve the resin infiltrant’s penetration ability into initial subsurface lesions.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"160 ","pages":"Article 105858"},"PeriodicalIF":4.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}