Journal of dentistry最新文献

{"title":"Examining the influence of parathyroid hormone-doped nanoparticles on resin-dentin interface strength and composition","authors":"Raquel Osorio,&nbsp;Fátima S. Aguilera,&nbsp;Enrique Fernández-Romero,&nbsp;Raquel Toledano,&nbsp;María T. Osorio,&nbsp;Manuel Toledano,&nbsp;Estrella Osorio","doi":"10.1016/j.jdent.2026.106340","DOIUrl":"10.1016/j.jdent.2026.106340","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to determine the remineralization capacity of etched dentin treated with polymeric nanoparticles (NPs) functionalized with parathyroid hormone (PTH) (PTH-NPs).</div></div><div><h3>Methods</h3><div>Dentin etched surfaces were treated with NPs and PTH-NPs. Treated interfaces were 24 h stored and, then, mechanically or thermally loaded. Interfaces were assessed through modulus of Young, Raman analysis and Masson’s trichrome staining microscopy.</div></div><div><h3>Results</h3><div>Specimens treated with PTH-NPs infiltration which were load cycled attained the highest modulus of Young. Remineralization throughout the total resin-dentin interface, referred to both phosphate and carbonate ions was unveiled in presence of PTH and dynamic loading, forming peritubular and intertubular dentin. The absence of NPs at the interface conditioned a scarce remineralization. After thermocycling, phosphate remineralization diminished at the interface in all groups, and carbonate only increased in the control group. Load cycling produced a higher minerals content and a major collagen crosslinking, contributing to generally augment both the mineral to matrix ratio and crystallinity.</div></div><div><h3>Conclusions</h3><div>PTH-NPs provoked a higher modulus of Young and a lower unprotected collagen web after conditioning and further resin infiltration, in load cycled samples. After dynamic load cycling, amorphous mineral was lower at the resin dentin interface, and crystallinity relative to phosphate was also greater after thermocycling at both hybrid layer and bottom of hybrid layer in case of PTH-NPs infiltration.</div></div><div><h3>Clinical significance</h3><div>Parathyroid hormone dentin infiltration, after phosphoric acid conditioning, has facilitated the reparative dentin formation at the resin-dentin interface, based on the nucleation of a more mature and soluble hydroxyapatite which facilitated remineralization.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106340"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The distributional impact of the UK soft drinks industry levy on dental care costs: An extended cost-effectiveness analysis","authors":"Salomon-Ibarra CC ,&nbsp;Toffolutti V ,&nbsp;Wu J ,&nbsp;Bernabe E","doi":"10.1016/j.jdent.2026.106511","DOIUrl":"10.1016/j.jdent.2026.106511","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the dental healthcare benefits among children and the financial impacts of the soft drinks industry levy (SDIL) as well as the distributional effects of benefits and costs across different socioeconomic groups in England, using real-world data.</div></div><div><h3>Methods</h3><div>We conducted an extended cost-effectiveness analysis (ECEA) to evaluate the impact of the SDIL on: (i) averted dental treatment activity and hospitalisations in children under 18 years, (ii) associated NHS cost savings and (iii) the distributional impact across deprivation quintiles, covering the period from April 2018 to December 2024. Dental treatment activity was obtained as courses of treatment (CoTs) by treatment bands from NHS Dental Statistics, while admissions for caries-related extractions were from Hospital Episode Statistics. Five separate interrupted time series models were fitted for CoTs (bands 1–3 and urgent care) and hospitalisations. Averted treatment was calculated as the absolute difference between predicted and counterfactual trends.</div></div><div><h3>Results</h3><div>3.48 (95% CI: 1.50, 5.67) million CoTs were avoided, saving £124.75 (48.32, 210.34) million. The largest reductions were in the second least deprived and middle quintiles whereas CoTs increased in the two most deprived quintiles. Furthermore, 53,093 (43,119, 62,209) dental hospitalisations were averted, saving £76.61 (60.22, 91.17) million. Reductions were observed across all deprivation quintiles, with the largest reductions among the two most deprived groups.</div></div><div><h3>Conclusion</h3><div>Dental treatment activity and dental hospitalisations among children fell following implementation of the SDIL, generating NHS cost savings in England. Differences by area deprivation were consistent with expected shifts in caries distribution and reductions in socioeconomic inequalities in childhood dental caries achieved through the SDIL.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106511"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saliva and salivary pellicle composition and proteomic profile in smokers vs. non-smokers and its effect on dental erosion","authors":"Philipp Kanzow ,&nbsp;Christof Lenz ,&nbsp;Frederike Schlarmann ,&nbsp;Sarah Barke ,&nbsp;Bianca Rohland ,&nbsp;Alexandra Schmidt ,&nbsp;Anastasiia Gorshkova ,&nbsp;Lisa Neuenroth ,&nbsp;Annette Wiegand","doi":"10.1016/j.jdent.2026.106517","DOIUrl":"10.1016/j.jdent.2026.106517","url":null,"abstract":"<div><h3>Objective</h3><div>To analyse the salivary composition and proteomic profile of saliva and the salivary pellicle in smokers compared to non-smokers, and to examine potential differences in the erosion-protective capacity of the salivary pellicle.</div></div><div><h3>Methods</h3><div>Twenty-five smokers and 25 non-smokers were included. Unstimulated and stimulated saliva samples were analysed regarding flow rate, pH, buffer capacity, calcium, phosphate, fluoride, and protein content. Saliva and salivary pellicle samples were analysed by data-independent acquisition mass spectrometry (DIA-MS) for proteome profiling. In an in situ experiment, intraoral splints were loaded with bovine enamel and dentine specimens for 120 min. Pellicle-covered specimens were extraorally eroded (HCl, pH 2.3, 60 s). Calcium release was determined photometrically and compared to pellicle-free controls.</div></div><div><h3>Results</h3><div>Except for phosphate in stimulated saliva (p_adj.=0.003), salivary parameters were not significantly different between smokers and non-smokers. Proteome profiling detected 1759±154 proteins (cumulative 1963) in saliva, and 4262±362 proteins (cumulative 4625) in the salivary pellicle. The relative abundances of 282 (unstimulated saliva), 338 (stimulated saliva), and 4 (salivary pellicle) protein groups differed significantly between smokers and non-smokers. Functional enrichment analysis of differentially abundant human proteins revealed biological processes such as coagulation, immune response, and carcinogenic reactive oxygen species processes to be impacted by smoking. The salivary pellicle had a significant erosion-protective effect in enamel compared to the control (41.4 ± 6.3 nmol/mm²), but no differences between smokers (33.2 ± 10.6 nmol/mm², p_adj.=0.001) and non-smokers (32.7 ± 8.6 nmol/mm², p_adj.=0.001) were found.</div></div><div><h3>Conclusion</h3><div>The proteomic profiles of both unstimulated and stimulated saliva and the salivary pellicle differ between smokers and non-smokers.</div></div><div><h3>Clinical significance</h3><div>Despite the different proteomic profiles indicating a significant impact of smoking on the oral cavity, the erosion-protective capacity of the salivary pellicle of smokers and non-smokers does not differ.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106517"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a deep learning classification model using a codeless platform for orthodontic extraction decision-making: Impact of image type on model performance","authors":"KyungMin Clara Lee","doi":"10.1016/j.jdent.2025.106296","DOIUrl":"10.1016/j.jdent.2025.106296","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the effect of image type on the performance of a deep learning classification model for decision-making in orthodontic treatment planning, and to investigate the clinical applicability of artificial intelligence in determining extraction and non-extraction treatment plans using intraoral photographs and digital model scans.</div></div><div><h3>Methods</h3><div>Pre-treatment patient data and orthodontic treatment plans were retrospectively collected from patients who had completed their orthodontic treatment. A total of 1200 intraoral photographs and 1200 digital scans of pre-treatment dental models were obtained, comprising 600 extraction cases and 600 non-extraction cases for each image type. All images were randomly divided into a training set (80 %), validation set (10 %), and a test set (10 %). A deep learning classification model was automatically developed using a codeless platform, which optimized the model through automated hyperparameter tuning without the need for manual coding. Model performance was evaluated by comparing accuracy, precision, recall, and F1 scores between the different image types.</div></div><div><h3>Results</h3><div>The performance of the deep learning model trained with intraoral photographs achieved an accuracy of 71.5 %, a precision of 72.2 %, a recall of 71.1 %, and an F1 score of 71.6 %. The performance of the deep learning model trained with digital scans showed an accuracy of 74.2 %, a precision of 74.6 %, a recall of 73.3 %, and an F1 score of 73.9 %. Overall, the model trained with digital scans demonstrated superior performance compared to the model trained with intraoral photographs.</div></div><div><h3>Conclusions</h3><div>This study elucidated the feasibility of developing an optimal deep learning classification model for determining extraction and non-extraction orthodontic treatment plans using intraoral photographs or digital model scans.</div></div><div><h3>Clinical significance statement</h3><div>Intraoral photographs or digital dental model images alone may assist clinical decision-making for orthodontic extraction planning through the application of artificial intelligence.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106296"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of smartphone cameras for measuring and analyzing dental shade: A systematic review","authors":"Talal Alhumoud ,&nbsp;Abdulkareem Zankawi ,&nbsp;Kar Yan Li,&nbsp;Ollie Yu,&nbsp;Edmond Pow,&nbsp;Walter Lam","doi":"10.1016/j.jdent.2026.106506","DOIUrl":"10.1016/j.jdent.2026.106506","url":null,"abstract":"<div><h3>Objective</h3><div>Digital Single Lens Reflex (DSLR) cameras have been commonly used in clinical settings for dental shade assessment. However, it remains unclear whether smartphone cameras can serve as a viable alternative to DSLR cameras for this purpose. This systematic review aimed to assess the performance of smartphone cameras for dental shade assessment compared to DSLR cameras.</div></div><div><h3>Methods</h3><div>This systematic review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines and was registered with PROSPERO (CRD42024580518). A comprehensive search was conducted using five electronic databases to identify eligible studies that comprised both <em>in vivo</em> and <em>in vitro</em> experimental designs. Two reviewers independently screened and selected the relevant studies, evaluated the risk of bias, and extracted relevant data for comparative analysis.</div></div><div><h3>Results</h3><div>A total of eight studies were included in this review: three conducted <em>in vivo</em>, three <em>in vitro</em>, and two in both settings. Seven studies used the CIELAB colour difference (ΔΕ*ab) as the primary metric. Overall, the evidence is mixed and does not show consistent superiority of either device. However, there was substantial heterogeneity among the studies in terms of camera models and settings, specimen types, reference methods, and assessment methods.</div></div><div><h3>Conclusion</h3><div>The evidence on the comparative performance of DSLR and smartphone cameras for dental shade assessment is mixed and characterised by substantial heterogeneity. Neither device type has demonstrated consistent superiority.</div></div><div><h3>Clinical Significance</h3><div>While both smartphone and DSLR cameras can be viable clinical tools for dental shade assessment, their performance is highly dependent on standardised protocols for lighting, calibration, and image capture.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106506"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conflict of interest and funding reporting by articles published in orthodontic journals: A cross-sectional investigation","authors":"Maurice J Meade ,&nbsp;Xiangqun Ju ,&nbsp;Lisa M Jamieson","doi":"10.1016/j.jdent.2025.106312","DOIUrl":"10.1016/j.jdent.2025.106312","url":null,"abstract":"<div><h3>Objective</h3><div>Information regarding potential conflict of interest (COI) and funding is essential for informed interpretation of research findings. The aim of the present cross-sectional investigation was to evaluate the reporting of COI and funding in articles published in orthodontic journals.</div></div><div><h3>Material and Methods</h3><div>Article titles contained within 14 orthodontic journals, selected from the Scopus orthodontic journal database, and published in 2023 were documented. Characteristics, including those related to COI and funding statements, of each article satisfying selection criteria were recorded.</div></div><div><h3>Results</h3><div>A total of 876 articles satisfied selection criteria. The median (interquartile range) number of authors per article was 5.0 (3.0, 6.0). Clinical studies (<em>n</em> = 253; 28.9%) were the most common article type published. Articles related to newer technologies and appliances were commonplace. Almost 90% (<em>n</em> = 784; 89.5%) of articles contained a COI statement. Twenty-five (2.9%) articles stated that there was a COI and provided details. Sixteen (1.8%) articles were determined to have a financial COI. A funding statement was made in 571(65.2%) articles. Of these, 257 (29.3%) declared that no funding was received, 179 (20.4%) were apparently from not-for-profit organisations and 17 (1.9%) from for-profit organisations. The source of funding in 114 (13.0%) articles was unclear. Fisher’s Exact test indicated that details where details of COI are provided, the odds of the details of funding increases (odds ratio: 14.13: 95% CI 9.3, 21.3; <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>COI and funding information appears to be underreported in orthodontic journals. This may indicate a requirement for orthodontic journals to improve COI disclosure processes.</div></div><div><h3>Clinical significance</h3><div>The underreporting of COI and funding information in published orthodontic research deters objective interpretation of research findings by readers. The outcomes of the present investigation highlight this important issue. Recommendations are provided with the objective of improving the robustness and transparency of COI and funding reporting processes.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106312"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a bioactive desensitizing material on in-office bleaching–induced tooth sensitivity: A randomized double-blind controlled trial","authors":"Ghada A. Maghaireh,&nbsp;Hanan Alzraikat,&nbsp;Majd Y. Altarazi","doi":"10.1016/j.jdent.2025.106326","DOIUrl":"10.1016/j.jdent.2025.106326","url":null,"abstract":"<div><h3>Objective</h3><div>This randomized clinical trial evaluated the effect of a bioactive glass desensitizer on the risk and intensity of tooth sensitivity and the color change resulting from in-office tooth bleaching with 40% hydrogen peroxide.</div></div><div><h3>Methods</h3><div>Fifty-one participants with upper central incisors shades A2 –A3.5 were randomly assigned to three groups: Predicta® Bioactive Desensitizer; fluoride gel; and a placebo gel. The assigned material was applied on teeth before bleaching with 40% hydrogen peroxide (2 × 20 min applications, two sessions, one week apart). Tooth sensitivity was recorded during and after the bleaching using a Visual Analogue Scale (VAS) and a Numerical Rating Scale (NRS). Color changes were evaluated using the Vita Classical (ΔSGU) and VITA EasyShade spectrophotometer (ΔE) before, immediately after bleaching, and one-month after bleaching. Data were analyzed using the Fisher’s Exact and Wilcoxon, Kruskal-Wallis for sensitivity and ΔSGU, while ∆E was analyzed with two-way repeated-measures (ANOVA). Significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>There was no significant difference in the absolute risk of tooth sensitivity between the three groups (p =1.000). A lower intensity of tooth sensitivity was observed between 1 and 48 h post bleaching for the Predicta® bioactive desensitizer in both scales (p &lt; 0.05). The two-color evaluation tools showed effective and similar bleaching over time in all three groups (p &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>The application of Predicta® immediately before in-office bleaching with 40% hydrogen peroxide did not lower the risk of tooth sensitivity or the intensity of sensitivity immediately after bleaching or within the first hour. However, a significant decrease in sensitivity intensity was observed from 1 to 48 h post-bleaching, without compromising bleaching efficacy.</div></div><div><h3>Clinical Significance</h3><div>Predicta® does not provide immediate protection against bleaching-induced tooth sensitivity. Its clinical benefit is characterized by a delayed reduction in sensitivity occurring after the first post-operative hour, which should be considered when counseling patients and managing post-bleaching discomfort. This clinical trial was registered at ClinicalTrials.gov; the registration number is NCT06532526.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106326"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulated bone for dental implant in vitro testing: A systematic review","authors":"Ulysses Lenz ,&nbsp;Pedro Henrique Wenz Tretto ,&nbsp;Jason Alan Griggs ,&nbsp;Alvaro Della Bona","doi":"10.1016/j.jdent.2026.106508","DOIUrl":"10.1016/j.jdent.2026.106508","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate methodological factors in the fabrication of simulated bone for dental implant testing and assess their relationship with reported clinical failure patterns.</div></div><div><h3>Method</h3><div>A systematic search was conducted in MEDLINE/PubMed, Scopus, and Web of Science following PRISMA. In-vitro studies published from 2015 on mechanically testing single-unit implants with simulated bone materials were included. Two reviewers performed screening, data extraction, and RoBDEMAT appraisal. Disagreements were resolved by a third reviewer. A narrative synthesis categorized bone material characteristics, bone loss simulation, loading angulation, and implant connection type, analyzing their influence on reported outcomes.</div></div><div><h3>Results</h3><div>From 2,472 records, 91 studies met the inclusion criteria. Most studies used single-layer simulated bone (81/91), predominantly autopolymerizing resins, while 10 employed two-layer cortical–cancellous bone analogs. Bone loss was mostly simulated using 3 mm (n=41). Loading was commonly applied at 30° (n=61), followed by 0° (n=21). The most frequent outcomes were screw loosening (n=21), screw fracture (n=19), abutment fracture (n=19), crown/veneer fracture (n=19), and implant fracture (n=19). Off-axis loading (30–45°) combined with crestal bone loss (∼3mm) tended to shift failures from screw/abutment to implant fractures. Conclusions: Reported laboratory failures partly align with clinical observations. Simulated bone loss level, bone stiffness and loading angle can influence failure patterns in dental implant testing. ISO 14801 and related standard protocols require update to better reflect current clinical data.</div></div><div><h3>Clinical significance</h3><div>Current laboratory tests do not fully reproduce contemporary peri-implant bone stability, limiting their clinical applicability. More realistic bone analogs may improve the clinical relevance of in-vitro studies.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106508"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation and bone loss prediction of titanium-zirconium implants: A retrospective study of 1-5-year follow-up","authors":"Zhaoting Ling ,&nbsp;Cong Chen ,&nbsp;Siyuan Wang ,&nbsp;Yun Zhu ,&nbsp;Xiaoting Shen ,&nbsp;Kefang Sun ,&nbsp;Hongye Lu ,&nbsp;Fuming He","doi":"10.1016/j.jdent.2026.106516","DOIUrl":"10.1016/j.jdent.2026.106516","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the clinical and radiographic outcomes of titanium-zirconium implants, identify risk factors and develop predictive models for bone loss progression.</div></div><div><h3>Methods</h3><div>Patients with titanium-zirconium implants were screened for inclusion and underwent follow-ups. Cumulative survival rates at the implant and patient levels were calculated using life tables. Clinical and radiographic data were retrospectively analyzed for implant/restoration success rates and peri-implant marginal bone loss. Factors influencing marginal bone loss were examined using generalized estimating equations (GEE). Support vector machine (SVM), artificial neural network (ANN), logistic regression (LR), and random forest (RF) were used to develop the prediction models of bone loss.</div></div><div><h3>Results</h3><div>573 titanium-zirconium implants from 399 patients were included, with an average observation time of 27.6 ± 11.5 months (12-63 months). The cumulative 5-year survival rate was 99.1% at the implant level, and 98.8% at the patient level. The mean probing depth was 3.1 ± 1.2 mm, with 23.6% incidence of bleeding on probing. The mean marginal bone loss was 0.37-0.52 mm. GEE analysis showed that marginal bone loss was significantly influenced by follow-up time, advanced age, narrow-diameter implant, location, and fixed partial denture. LR and ANN models demonstrated optimal predictive performance, both with 93.5% accuracy. Baseline marginal bone level emerged as the most significant predictor, with an importance score of 41.3.</div></div><div><h3>Conclusions</h3><div>The 1-5-year outcomes revealed that titanium-zirconium implants achieved high survival and success rates, with limited marginal bone loss. The prediction model demonstrated 93.5% accuracy, identifying baseline marginal bone level as the primary determinant of bone loss progression.</div></div><div><h3>Clinical Significance</h3><div>Titanium-zirconium implants achieve satisfactory clinical outcomes and identifies the baseline marginal bone level as the primary determinant of bone loss progression. (clinical trial registration number: ChiCTR2300069888)</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106516"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic adhesives incorporated with strontium-containing fluorapatite for improved remineralizing effect","authors":"Ji-Yeon Hong ,&nbsp;Ji-Eun Kim ,&nbsp;Jae-Sung Kwon","doi":"10.1016/j.jdent.2026.106518","DOIUrl":"10.1016/j.jdent.2026.106518","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to develop novel orthodontic adhesives with remineralization effect to prevent white spot lesions (WSLs) by adding strontium-containing fluorapatite (Sr-FAp), fluorapatite (FAp), and strontium-containing hydroxyapatite (Sr-HAp).</div></div><div><h3>Methods</h3><div>The particles were synthesized and characterized. The experimental groups consisted of a commercial control (CC), control (30 wt % resin matrix + 70 wt % glass filler), and experimental groups with 17.5 wt % of filler replaced by Sr-FAp, FAp, or Sr-HAp. The brackets were bonded to the enamel surface and the shear bond strength (SBS) and adhesive remnant index were tested. The release of calcium (Ca), phosphorus (P), strontium (Sr), and fluoride (F) ions from adhesive specimens in distilled water was evaluated after 15, 30, 60 days. The remineralization effect was observed the microhardness and surface morphology using scanning electron microscopy with energy dispersive spectroscopy.</div></div><div><h3>Results</h3><div>Except for the FAp, no significant differences in SBS were observed (<em>p</em> &gt; 0.05). Ion release results showed Ca, P, Sr, and F ions were detected in the Sr-FAp group up to 60 days. The Sr-FAp group showed the highest microhardness (<em>p</em> &lt; 0.05), and the largest amount of fluorapatite-like layer (Ca/P: 1.69) was formed after 60 days of immersion.</div></div><div><h3>Conclusion</h3><div>The Sr-FAp group showed acceptable SBS while exhibiting the highest microhardness and the most pronounced formation of a fluorapatite-like layer, indicating its effectiveness in preventing WSLs during orthodontic treatment.</div></div><div><h3>Clinical significance</h3><div>The orthodontic adhesive containing Sr-FAp offers potential clinical benefits by preventing demineralization and promoting remineralization of the enamel surface surrounding orthodontic brackets.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"166 ","pages":"Article 106518"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}